CN101172119A - Cordyceps sinensis lucid ganoderma oral liquid and its preparing process - Google Patents
Cordyceps sinensis lucid ganoderma oral liquid and its preparing process Download PDFInfo
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- CN101172119A CN101172119A CNA2006101377513A CN200610137751A CN101172119A CN 101172119 A CN101172119 A CN 101172119A CN A2006101377513 A CNA2006101377513 A CN A2006101377513A CN 200610137751 A CN200610137751 A CN 200610137751A CN 101172119 A CN101172119 A CN 101172119A
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Abstract
The invention discloses a Chinese caterpillar fungus and ganoderma lucidum oral liquid, and the oral liquid comprise the following components: 40 to 80 percents of Chinese caterpillar fungus mycelium, 5 to 15 percents of ganoderma lucidum mycelium, 4 to 10 percents of grifola frondosa mycelium, 2 to 5 percents of the extractive concentrated solution of Chinese caterpillar fungus, 5 to 15 percents of the extracting solution of chinese herbal medicine and 0.02 to 0.12 percents of agar, honey with proper amount, albumen and purified water The invention has the preparation method that multifold funguses are fermented at the same time, each fungus is put in a fermentation tank separately to be cultivated, the cultivation period of each fungus is different, but each fungus can be arranged at the same mature time through a controller, so as to be convenient for a finished product being prepared according to a formula in good time. An upper abacterial air pipeline (12), an air outlet pipeline (13), and a lower abacterial air pipeline (14) are arranged in a reactor, and upper ventilation and lower ventilation are adopted to mix. The invention has the advantages that the growth time of mushrooms such as cordyceps, ganoderma lucidum and so on are shortened, the invention can be manufactured in batch quantity industrially, so as to overcome the exhaustion of the wildlife resource and lead the cost to be greatly reduced, and the output is improved.
Description
Technical field
Technical solutions according to the invention belong to the medicinal preparation field, concretely, are to belong to the medicinal preparation that derives from the vegetable material higher fungi, according to International Patent Classification, belong to the A61K35/84 field.
Background technology
Cordyceps is traditional rare Chinese medicine, has important medical health care function.Modern study shows that Cordyceps has effects such as resisting fatigue, anoxia enduring, defying age, anti-lung tumor and raising immune function of human body.But nourishing the lung and kidney, hemostasis and phlegm, relieving asthma, expand trachea, calmness, anti-all kinds of through bacterium, blood pressure lowering improves blood supply of cardiac muscle.Measurement result shows, contains cordycepin, Cordyceps polysaccharide, cordycepic acid (D-mannitol), the necessary aminoacid of multiple human body in the Cordyceps, healthy trace elements with household and little element, superoxide dismutase multiple nutrients material and anticancer antidotal active substances such as (SOD) of giving birth to.The domestic several formulations of having developed all has good curative effect on the adjuvant drug of treatment cardiovascular, liver, kidney, respiratory system, hematologic disease and antineoplaston.
Ganoderma has kinds such as Ganoderma lucidum (Leyss. Ex Fr.) Karst., Ganoderma, Fructificatio Amaurodermatis Rudae, Ganoderma lucidum seu Japonicum, Radix Angelicae Dahuricae, Rhizoma Polygonati, be giving young employees remedial-courses in general knowledge and vocational skills QI and blood, spleen invigorating lung benefiting, the integration of edible and medicinal herbs fungus of benefit heart and tranquilizing mind, be usually used in the grand slowly obstructive pulmonary disease of coronary heart disease, arrhythmia, the viral liver of acute and chronic, hyperlipoproteinemia, fatty liver, leukopenia, immunologic hypofunction, the treatment that malignant tumor etc. are sick.Other edible mushroom fungus kind is a lot, but China's artificial implantation have nearly hundred kinds, and its delicious food, nutrition also have different pharmaceutical to be worth.
Cordyceps and Ganoderma are the rare Chinese medicines of determined curative effect, but because the exhaustion of wild resource, it costs an arm and a leg, and is difficult to give popular the use, last century middle and late stage, artificial implantation makes progress, but still has the long production cycle, cost is also higher.
Existing cordyceps militaris oral liquid, a kind of Chinese medicine multiple bacteria compound fermentation oral liquid compounding and production technology thereof are disclosed as Chinese patent 03 1 23015.6, it is by multiple bacteria compound fermentation, because of different strain fermentation culture fluid and condition of culture variant, so performance difficulty.The present invention is a plurality of strains, and each is cultivated in a fermentation tank separately, and nutritional solution and manufacturing condition are with strong points, and is easy to control, efficient is high, quality good.Each culture of strains cycle difference, but overall arrangement is ripe at one time, in order to make qualified products by prescription in good time.
Disclose a kind of " oral liquor of fermented cordyceps hypha " as Chinese patent 93 1 04720.x, it is single raw material, lacks the scope of application widely that the present invention is the product that a plurality of strains ferment simultaneously.Chinese patent 99 1 21894.9 " a kind of new be used for the biological respinse product that microbial liquid is cultivated " and for example, it is a kind of gas formula reactor of novel low recirculating zone.In order to add the perturbed force of air blast, the present invention adopts all the compressed air of air inlet pipe by filtering oil, dust cleaning and sterilizing up and down, to enhance productivity.
Summary of the invention
The purpose of this invention is to provide a kind of a plurality of strain and ferment simultaneously, the Cordyceps Ganoderma oral liquid of the cheapness that effect is the same with natural prodcuts, production in enormous quantities.
The objective of the invention is to realize in the following manner:
The method that adopts the many strains of biological engineering to ferment is simultaneously produced the compound oral liquid of multiple mushroom fungus, and its prescription is as follows: below be weight percentage:
(A) Cordyceps mycelium 40～80%
(B) Ganoderma mycelium 5～15%
(C) maitake mushroom mycelia 4～10%
(D) Cordyceps extracts concentrated solution 2～5%
(E) extracts of Chinese herbal medicine 5～15%
(F) agar powder 0.02～0.12%
(G)PH：5.0
Mel 3～5%
Extract of protein 3～5%
Purified water 5～15%
Other adds: following is percent by volume:
Herba Cistanches 100～200g/ liter
Herba Epimedii 50～120g/ liter
Rhizoma Polygonati Odorati sheet 50～120g/ liter
Radix Ophiopogonis 50～120g/ liter
Fructus Corni 50～120g/ liter
The present invention adopts the technology of biological engineering fermenting process of preparing as follows:
Jar → allotment → canned → sterilization → semi-finished product → packing → warehouse-in is cultivated → put to natural strains separation → natural bacterial strain purification → engineered strain screening → engineered strain slant culture → engineered strain liquid culture → engineered strain secondary liquid culture → inoculation → one-level cultivation → secondary.These all are universal methods.
At first gather wild Chinese caterpillar fungus, Ganoderma and other mushroom fungus, obtain spore powder, cultivate again, strain separating, evaluation, strains such as Cordyceps, Ganoderma are preserved.Carry out actication of culture during use, make first order seed, secondary seed is made in diffusion again, enters fermentation tank and carries out fermentation culture, finishes fermentation, and generates mycelia in 5～25 days.After making extracting solution, this mycelia is cooperated by following prescription: carry out fill, sterilization deactivation, packing, manufactured goods.
Fill in 30ml/ props up the ground glass bottle, light ecru suspension.
Culture technique parameter: tank pressure: 0.05MPa, logical oxygen: 1: 0.8～1, temperature: 26 ± 1 ℃
Physical and chemical index:
1, pH value 4.2
2, total arsenic [mg/L]:＜0.10 (in AS)
3, copper (Cu) [mg/L]:＜1.0
4, plumbous (Pb) [mg/L]:＜0.05
5, total plate count [cfu/ml]: 0
6, coliform [MPN/100ml]:＜3
7, mycete [cfu/ml]: 0
8, yeast [cfu/ml]: 0
9, Salmonella: do not detect
10, shigella: do not detect
11, golden Fructus Vitis viniferae pearl bacterium: do not detect
Description of drawings
Fig. 1 Cordyceps Ganoderma oral liquid preparation flow sketch map.
Fig. 2 Cordyceps Ganoderma oral liquid reactor sketch map.
The specific embodiment
Embodiment 1:
(A) Cordyceps mycelium 70%
(B) Ganoderma mycelium 6%
(C) maitake mushroom mycelia 6%
(D) Cordyceps extracts concentrated solution 2%
(E) extracts of Chinese herbal medicine 16%
(F) agar powder 0.12%
(G)PH：5.0
Embodiment 2:
(A) Cordyceps mycelium 68%
(B) Ganoderma mycelium 8%
(C) maitake mushroom mycelia 6%
(D) Cordyceps extracts concentrated solution 2%
(E) extracts of Chinese herbal medicine 16%
(F) agar powder 0.12%
(G)PH：5.0
Embodiment 3:
(A) Cordyceps mycelium 72%
(B) Ganoderma mycelium 5%
(C) maitake mushroom mycelia 6%
(D) Cordyceps extracts concentrated solution 2%
(E) extracts of Chinese herbal medicine 16%
(F) agar powder 0.12%
(G)PH：5.0
Embodiment 4:
(A) Cordyceps mycelium 68%
(B) Ganoderma mycelium 9%
(C) maitake mushroom mycelia 6%
(D) Cordyceps extracts concentrated solution 2%
(E) extracts of Chinese herbal medicine 16%
(F) agar powder 0.12%
(G)PH：5.0
Embodiment 5:
(A) Cordyceps mycelium 72%
(B) Ganoderma mycelium 7%
(C) maitake mushroom mycelia 6%
(D) Cordyceps extracts concentrated solution 2%
(E) extracts of Chinese herbal medicine 16%
(F) agar powder 0.12%
(G)PH：5.0
Fig. 1 is a Cordyceps Ganoderma oral liquid preparation flow sketch map.As can be seen from the figure, this flow sheet equipment comprises jacketed pan 1, centrifuge 2, compensator 3, filter 4, material-compound tank 5, seed tank 6, seed tank 7, froth breaking jar 8, seed tank 9, seed tank 10 and fermentation tank 11.These all are common apparatus.The invention is characterized in that a plurality of strains ferment simultaneously, each strain is cultivated in a fermentation tank separately, and nutritional solution and manufacturing condition are with strong points, and is easy to control, efficient is high, quality good.Each culture of strains cycle difference, can overall arrangement ripe at one time by controller, in order to make qualified products by prescription in good time.
Fig. 2 is a Cordyceps Ganoderma oral liquid reactor sketch map.This reactor is meant 6,7,9,10 and fermentation tanks 11 of four seed tanks, filtrated air pipeline 12, outlet pipe 13 and following filtrated air pipeline 14 all are housed on it, use upper and lower air agitation instead by not being with mechanical agitation, more favourable mycelial growth glues the wall problem with overcoming, and has improved mycelia quality and output greatly.
The present invention compared with prior art has the following advantages:
1, many bacterial classifications while ferment obtain the good oral liquid of a kind of composite performance.
2, shortened the growth time of the gill fungus bacterium such as Chinese caterpillar fungus, glossy ganoderma, made it wild 2～6 years Time or the time of cultivating 3～6 months become fermenting and producing only needs 5～25 day time.
3, industrialized mass production has overcome the difficult problem of wild resource exhaustion, and cost is reduced greatly, Output increased can satisfy the demands.
4, adopt the Zymolysis Equipment of submerged fermentation, be not with mechanical agitation and use upper and lower ventilation instead and stir Mix, more favourable bacterium is than growth and overcome sticking wall problem, has greatly improved mycelia quality and output.
Claims (3)
1. Cordyceps Ganoderma oral liquid, it is characterized in that: it is as follows to fill a prescription:
(A) Cordyceps mycelium 40～80%
(B) Ganoderma mycelium 5～15%
(C) maitake mushroom mycelia 4～10%
(D) Cordyceps extracts concentrated solution 2～5%
(E) extracts of Chinese herbal medicine 5～15%
(F) agar powder 0.02～0.12%
Proper honey, extract of protein, purified water.
2. the preparation method of a Cordyceps Ganoderma oral liquid, it is characterized in that: multiple strain ferments simultaneously, and each strain is cultivated in a fermentation tank separately, each culture of strains cycle difference, can overall arrangement ripe at one time by controller, in order to make product by prescription in good time.
3. the preparation method of Cordyceps Ganoderma oral liquid according to claim 2, it is characterized in that: filtrated air pipeline (12), outlet pipe (13) and following filtrated air pipeline (14) are housed in the described reactor, and employing is not with mechanical agitation and is used upper and lower air agitation instead.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102860501A (en) * | 2011-07-07 | 2013-01-09 | 韩淑娜 | Formula and preparation method of lucid ganoderma cordyceps militaris maitake health protection dissolved medicines |
| CN104547546A (en) * | 2014-12-26 | 2015-04-29 | 扬子江药业集团四川海蓉药业有限公司 | Traditional Chinese medicinal composition for reinforcing kidney and moistening lung and preparation method of traditional Chinese medicinal composition in different dosage forms |
| CN104997815A (en) * | 2015-07-08 | 2015-10-28 | 哈尔滨瑞康源生物科技有限公司 | Cordyceps sinensis and Mythic Fungus fermentation powder composite lozenge and preparation method thereof |
| CN108668784A (en) * | 2018-05-24 | 2018-10-19 | 项韵男 | A kind of mycelial breeding method of polynary strain |
-
2006
- 2006-10-30 CN CNA2006101377513A patent/CN101172119A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102860501A (en) * | 2011-07-07 | 2013-01-09 | 韩淑娜 | Formula and preparation method of lucid ganoderma cordyceps militaris maitake health protection dissolved medicines |
| CN102860501B (en) * | 2011-07-07 | 2013-08-28 | 韩淑娜 | Formula and preparation method of lucid ganoderma cordyceps militaris maitake health protection dissolved medicines |
| CN104547546A (en) * | 2014-12-26 | 2015-04-29 | 扬子江药业集团四川海蓉药业有限公司 | Traditional Chinese medicinal composition for reinforcing kidney and moistening lung and preparation method of traditional Chinese medicinal composition in different dosage forms |
| CN104547546B (en) * | 2014-12-26 | 2018-03-02 | 扬子江药业集团四川海蓉药业有限公司 | A kind of Chinese medicine composition of kidney tonifying moistening lung and its preparation method of different dosage forms |
| CN104997815A (en) * | 2015-07-08 | 2015-10-28 | 哈尔滨瑞康源生物科技有限公司 | Cordyceps sinensis and Mythic Fungus fermentation powder composite lozenge and preparation method thereof |
| CN108668784A (en) * | 2018-05-24 | 2018-10-19 | 项韵男 | A kind of mycelial breeding method of polynary strain |
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Open date: 20080507 |