CN101167814A - Traditional Chinese medicine for treating kidney yin deficiency and deficiency of both yin and yang and preparation method - Google Patents
Traditional Chinese medicine for treating kidney yin deficiency and deficiency of both yin and yang and preparation method Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for curing yin-deficiency of the kidney and symptoms of yin and yang deficiency whose tablet, pelletized granule, capsule, and oral administration mixture are made from fruit of Chinese wolfberry, radix polygoni multiflori, black soya bean mulberry, kudzuvine root, schisandra fruit, cornus officinalis, panax ginseng, lumbricus, pilose antler, scalded dog kidney, and scalded cow kidney and findings. The medicament method is that the cornus officinalis, the panax ginseng, the pilose antler, the scalded dog kidney, and the scalded cow kidney are crushed into fine powder for reserve, the rest seven-part medicines such as the fruit of Chinese wolfberry and the like are charged with water and is fried and boiled twice, 10 times of water is added and the rest seven-part medicines with 10 times of water are fried and boiled for two hours and are filtered for the first time, and 8 times of water is added and the rest seven-part medicines with 8 times of water are fried and boiled for two hours and are filtered for the second time. The filter liquors are merged and are condensed to clear paste with the relative density of 1.30-1.35 when in 40 DEG C to 50 DEG C, and the merged liquor is filled with the medicine powder, and is evenly mixed, and is decompressing and is dried under 70 DEG C, and is crushed, and is filtered by a screen with 100 orders, and is prepared into traditional medicine powder. The traditional medicine powder is filled with transporting material and is mixed, thereby the invention is made. The invention is applicable to curing yin-deficiency of the kidney and symptoms of yin and yang deficiency, and has the advantages of reasonable medicament arts, high medicine efficiency, precise component, convenient carrying, and has no side effect, and is applicable to patients with different requirements on the dosage form.
Description
Technical field
The present invention relates to Chinese medicine, particularly relate to the Chinese medicine and the preparation method for the treatment of deficiency of the kidney yin, deficiency syndrome of both YIN and YANG.
Background technology
Deficiency of the kidney yin and syndrome of deficiency of both yin and yang of kidney, clinical manifestation impotence and premature ejaculation, seminal emission night sweat, lumbago giddy, insomnia dysphoria with smothery sensation, the empty syndrome such as weak of body.The traditional Chinese medical science is thought main YIN and YANG balance regulating, temperature male wind-supplying kidney, the controlling nocturnal emission with astringent drugs of calming the nerves, strengthening the body resistance.The disease Chinese medicine preparation that treating at present suffers from a deficiency of the kidney causes is a lot, have certain effect in theory, propaganda strength is also very big on the market, but great majority lack the strict design foundation, scientific and technological content is lower, for the pharmacological effect research of carrying out systematic science, clinical control observe and the kind preparation of untoward reaction research but seldom, so therapeutic effect is undesirable, exist treatment cycle long, problems such as easy recurrence.
Summary of the invention
The technical problem to be solved in the present invention, provide that a kind of scientific formulation is reasonable, composition is accurate, the pharmaceutical technology advanced person, obvious through the clinical observation treatment effect, instant effect, have no adverse reaction, be fit to the various dosage forms of patient demand and the treatment deficiency of the kidney yin of taking convenience, the Chinese medicine and the preparation method of deficiency syndrome of both YIN and YANG.
The technical scheme that adopts is:
The Chinese medicine of treatment deficiency of the kidney yin, deficiency syndrome of both YIN and YANG is by Fructus Lycii, Radix Polygoni Multiflori, Semen sojae atricolor, Fructus Mori, Radix Puerariae, Fructus Schisandrae Chinensis, Fructus Corni, Radix Ginseng, Pheretima, Cornu Cervi Pantotrichum, scald Testis et Pentis Canis, scald Ren Bovis seu Bubali and adjuvant is mixed with tablet, granule, capsule and oral mixture.Its prescription is Fructus Lycii 150g, Radix Polygoni Multiflori 150g, Semen sojae atricolor 150g, Fructus Mori 75g, Radix Puerariae 150g, Fructus Schisandrae Chinensis 75g, Fructus Corni 75g, Radix Ginseng 15g, Pheretima 75g, Cornu Cervi Pantotrichum 15g, scalds Testis et Pentis Canis 20g, scalds Ren Bovis seu Bubali 20g.
Above-mentioned adjuvant comprises starch, pregelatinized Starch, soluble starch, dextrin, magnesium stearate, Pulvis Talci, calcium sulfate, microcrystalline Cellulose, cane sugar powder, steviosin, sodium benzoate and distilled water.
The Chinese medicinal preparation method of treatment deficiency of the kidney yin, deficiency syndrome of both YIN and YANG, get Fructus Lycii 150g, Radix Polygoni Multiflori 150g, Semen sojae atricolor 150g, Fructus Mori 75g, Radix Puerariae 150g, Fructus Schisandrae Chinensis 75g, Fructus Corni 75g, Radix Ginseng 15g, Pheretima 75g, Cornu Cervi Pantotrichum 15g, scald Testis et Pentis Canis 20g, scald Ren Bovis seu Bubali 20g, with Fructus Corni, Radix Ginseng, Cornu Cervi Pantotrichum, scald Testis et Pentis Canis, scalding Ren Bovis seu Bubali, to be ground into fine powder standby.Seven flavor medicines such as all the other Fructus Lycii decoct with water twice, add 10 times of water gagings for the first time, decoct two hours, filter; For the second time add 8 times of water gagings, decocted two hours, filter; Merging filtrate is concentrated into the clear paste of relative density 1.30-1.35 (40-50 ℃ of survey), adds above-mentioned medicated powder, mixing, in drying under reduced pressure below 70 ℃, pulverizing, mistake 100 mesh sieves, be prepared into Chinese medicine powder, in Chinese medicine powder, add appropriate amount of auxiliary materials and be mixed and made into tablet, capsule.
The above-mentioned Chinese medicine powder that is prepared into is granulated drying with the 5-15% starch slurry, add the magnesium stearate of grain amount .5% and 1% Pulvis Talci mixing, be pressed into 1000, every contains crude drug 0.97g, sugar coating is made sugar coated tablet (trade name is three sub fine and soft kidney coated tablets).
The above-mentioned Chinese medicine powder that is prepared into adds calcium sulfate 11g, pregelatinized Starch 1.95g, microcrystalline Cellulose 3.3g, mixing, granulate with the 8-15% syrup, drying adds the magnesium stearate of grain amount 0.5% and 1% Pulvis Talci mixing, be pressed into 1000, every contains crude drug 0.97g; Perhaps be pressed into 500, every contains crude drug 1.94g, and the bag film-coat is made Film coated tablets (trade name is three sub fine and soft kidney Film coated tablets).
The above-mentioned Chinese medicine powder that is prepared into is granulated drying with the 5-15% starch slurry, add the magnesium stearate of grain amount .5% and 1% Pulvis Talci mixing, be filled in behind the granulate in the Capsules, make 1000 altogether, every contains crude drug 0.97g, makes capsule (commodity are called three sub fine and soft kidney capsules).
The Chinese medicinal preparation method of above-mentioned treatment deficiency of the kidney yin, deficiency syndrome of both YIN and YANG, also can take by weighing medical material by prescription after, Radix Ginseng, Pulveratum Cornu Cervi Pantotrichum are broken into fine powder, standby.Ten flavor medicines such as all the other Fructus Lycii decoct with water twice, add 10 times of water gagings for the first time, decoct two hours, filter; For the second time add 8 times of water gagings, decocted two hours, filter; Merging filtrate, being concentrated into relative density is the clear paste of 1.30-1.35 (40-50 ℃ of survey), the best quantities received of clear paste accounts for 33% of the material total amount of offeing medicine, and adds above-mentioned medicated powder, mixing, clear paste and the medicated powder of getting mixing add 4.7 parts of cane sugar powders for 1 part, mixing is made dried granule 1600g, is distributed into every bag of 8g, every bag is equivalent to crude drug 4.85g, makes to contain sugared granule (trade name is that three sub fine and soft kidneys contain sugared granule).
The Chinese medicinal preparation method of above-mentioned treatment deficiency of the kidney yin, deficiency syndrome of both YIN and YANG, also can take by weighing medical material by prescription after, Radix Ginseng, Pulveratum Cornu Cervi Pantotrichum are broken into fine powder, standby.Ten flavor medicines such as all the other Fructus Lycii decoct with water twice, add 10 times of water gagings for the first time, decoct two hours, filter; For the second time add 8 times of water gagings, decocted two hours, filter; Merging filtrate, being concentrated into relative density is the clear paste of 1.30-1.35 (40-50 ℃ of survey), adds above-mentioned medicated powder, mixing in 70 ℃ of following drying under reduced pressure, is pulverized, cross 100 mesh sieves, the powder that gets dry extract, the best quantities received of dried cream powder accounts for 15% of medical material amount, get 1 part of dried cream powder, it is an amount of to add 1 portion of soluble starch, 0.8 part of dextrin, steviosin, mixing, make dried granule 400g, be distributed into every bag of 2g, be equivalent to crude drug 4.85g, make sugar free granule (trade name is three sub fine and soft kidney sugar free granule).
The Chinese medicinal preparation method of above-mentioned treatment deficiency of the kidney yin, deficiency syndrome of both YIN and YANG, also can take by weighing medical material by 1/2nd of prescription amount after, Radix Ginseng, Pulveratum Cornu Cervi Pantotrichum are broken into coarse powder; Pheretima, boiling hot Testis et Pentis Canis, boiling hot Ren Bovis seu Bubali section add 50 and spend Chinese liquor 500ml dipping secondaries, add 300ml the first time, and add 200ml the second time, and each 12 hours, merge steeping in wine liquid twice, filter, it is standby to get medicinal liquid; Medicinal residues and all the other seven flavor medicines decoct with water twice, add 8 times of water gagings at every turn, decoct 1.5 hours, merging filtrate filters, and being concentrated into relative density is the clear paste of 1.10-1.12 (60-70 ℃ of survey), add ethanol and make that to contain alcohol amount be 70%, stir evenly, left standstill 12 hours, filter, filtrate recycling ethanol adds above-mentioned steeping in wine liquid, sodium benzoate 5g, sucrose 100g to there not being the alcohol flavor, adding distil water is to 1000ml, stir evenly, be distributed into every bottle of 30ml or 1 00ml, make oral mixture (trade name is three sub fine and soft kidney mixture).
The side separates:
Invigorating the liver and kidney such as Fang Zhongxuan Radix Polygoni Multiflori, Fructus Corni, Semen sojae atricolor, Fructus Mori, beneficial marrow and strengthening bone and muscle.Cornu Cervi Pantotrichum is mended governor vessel, benefiting essence-blood.Testis et Pentis Canis, Ren Bovis seu Bubali the kidney invigorating play fistula, the Fructus Lycii YIN nourishing and YANG strengthening, and three flavors are intended to treating YIN within YANG, Yin grows while yang is generating.The Radix Ginseng strongly invigorating primordial QI keeps fit to take off admittedly to promote the production of body fluid, treatment sexual life sweating, and sweating has special effect between cloudy strand, declines the power of recovering development is arranged greatly cause physical void because of indulgence in drinking and sexsual activity.The Fructus Schisandrae Chinensis tranquilizing mind, strong water town sun.Radix Puerariae has had the merit of the moon; Pheretima is agile product " the southern regions of the Yunnan Province book on Chinese herbal medicine " cloud: " strong muscle is controlled fistula ".Full side is the merit of YIN nourishing and YANG strengthening altogether, is applicable to the disease that deficiency of the kidney yin and kidney insufficiency cause.
The Pharmacodynamic test of active extract of this Chinese medicine
This Chinese medicine mainly has the YIN nourishing and YANG strengthening effect, by Shenyang Pharmaceutical University by to the influence of deficiency of the kidney yin model mice and insufficiency of kidney-YANG model mice, for the YIN nourishing and YANG strengthening effect of this Chinese medicine preparation provides modernized pharmacodynamics foundation.The concrete practice is this Chinese medicine to the influence test of syndrome of deficiency of kidney yin mice due to the thyroxine; Influence test to syndrome of deficiency of kidney-YANG mice due to the hydrocortisone.
This Chinese medicine is to the influence test of syndrome of deficiency of kidney yin mice due to the thyroxine.Use the pathological phenomenon that heavy dose of thyroxine can cause the similar human deficiency of the kidney yin of animal, amount of drinking water can appear in animal to be increased, fervescence, and the body oxygen consumption increases, and adrenal gland's weight increases, and thymic weight reduces symptom.Therefore to the syndrome of deficiency of kidney yin mice respectively to the test of amount of drinking water normal pressure hypoxia endurance time, adrenal gland and thymic weight, mice body surface temperature.Result of the test shows: this Chinese medicine has obvious antagonism to the hypoxia-bearing capability decline of syndrome of deficiency of kidney yin mice; Amount of drinking water increased the reduction effect; Adrenal gland's weight is increased, and thymic weight reduces certain antagonism; Fervescence there is certain antagonism.
This Chinese medicine is to the influence test of syndrome of deficiency of kidney-YANG mice due to the hydrocortisone.The disease of syndrome of deficiency of kidney-YANG mice reason phenomenon, the independent activity of animals amount reduces, body weight gain slowly, low-temperature resistance stress ability drop, the body temperature card shape that descends.Therefore the syndrome of deficiency of kidney-YANG mice is carried out the test of autonomic activities, body weight gain, low temperature swimming time, mouse temperature respectively to mice.Result of the test shows: this Chinese medicine is slow to the minimizing of syndrome of deficiency of kidney-YANG mice autonomic activities amount, body weight gain, the low-temperature resistance stress ability drop all presents remarkable antagonism, yang deficiency syndrome motion body temperature is had the rising effect, and rising there is certain reduction effect to the syndrome of deficiency of kidney yin animal heat.
Toxicity test
This toxicity test is assisted experiment by institute of materia medica, Liaoning Province.Adopt the LD50 of gastric infusion to measure, provide 35 of body weight 19-22 gram Kunming mouses by animal housing of Shenyang Pharmaceutical University, male and female half and half, experiment is carried out in two batches, each 10 of first male and female, totally 15 of the second batch of male and female, all in 24 hours, give twice of same dosage 10g/kg gastric infusion, 12 hours at interval, every batch of experiment was all raised seven days under 24-26 ℃ of condition, and totally 35 mices of two batches of experiments in result front and back all do not have death.Concentration is a viscous solution in this, has been maximum dosage-feeding from drug level and administration volume, irritates this Chinese medicine of stomach 20g/kg in 24 hours altogether and does not produce death, can not do LD50.
Treatment by Chinese herbs syndrome of deficiency of kidney yin of the present invention and syndrome of deficiency of both yin and yang of kidney clinical observation:
Chinese medicine of the present invention is on the basis of finishing pharmacy, pharmacodynamics, toxicity test, for further verifying its clinical efficacy, by the Liaoning Prov. Traditional Chinese Medicine Inst, the Shenyang City academy of traditional Chinese medicine and three tame medical institutions of Benxi Hospital of Traditional Chinese Medicine have carried out the clinical observation on the therapeutic effect of 100 examples.Among the 100 routine clinical observation patients, syndrome of deficiency of kidney yin 70 examples, syndrome of deficiency of both yin and yang of kidney 30 examples; Male's 79 examples, women's 21 examples.
Diagnostic criteria:
1, syndrome of deficiency of kidney yin
Cardinal symptom: soreness of the waist and knees; Dysphoria with feverish sensation in the chest palms and soles.
Minor symptom: have a dizzy spell; Deaf; Tinnitus; Two dryness and uneasy feeling of the eye; Sexual hypofunction; Dry mouth and throat; Insomnia; Forgetful; Night sweat; Constipation; Red tongue, few tongue or no fur; Thready and rapid pulse.
Possess three of primary symptom binomial and time diseases, diagnosable is syndrome of deficiency of kidney yin.
2, syndrome of deficiency of both yin and yang of kidney
Cardinal symptom: soreness of the waist and knees; Aversion to cold and cold limbs; Dysphoria with feverish sensation in the chest palms and soles.
Minor symptom: asthenia facial edema; Dribble of urine; Sexual hypofunction (or seminal emission, premature ejaculation); Spiritlessness and weakness; Breathe hard and breathe heavily; Have a dizzy spell; Big loose stool is thin; Constipation; Two dryness and uneasy feeling of the eye; Deaf; Tinnitus; The xerostomia pharynx is made an uproar; Lose eye; Forgetful; Night sweat; Light red tongue fat and moisten, the white thick or few tongue of red tongue of tongue, no fur; Deep-slow pulse or count accurately.
Possess three of primary symptoms, inferior disease binomial, diagnosable is syndrome of deficiency of both yin and yang of kidney.
Curative effect determinate standard:
1, produce effects: cardinal symptom significantly takes a turn for the better, and minor symptom disappears substantially.
2, effective: cardinal symptom takes a turn for the better, and minor symptom is partly improved.
3, invalid: main, minor symptom does not all have improvement.
Oral 3 times of every day, 4 weeks of the course of treatment, as a result in 70 examples of syndrome of deficiency of kidney yin observation group, produce effects 36 examples, effective 31 examples, wherein obvious effective rate 51.43%, total effective rate 95.7%.In 30 examples of syndrome of deficiency of both yin and yang of kidney observation group, produce effects 7 examples, effective 22 examples, wherein obvious effective rate 23.33%, total effective rate 96.67%.
Function with cure mainly:
Replenishing kidney-YIN, life essence-filling, marrow-benefitting.Be used for deficiency of the kidney yin and syndrome of deficiency of both yin and yang of kidney patient, disease is seen soreness of the waist and knees, and giddy is weak, insomnia, night sweat etc.
Usage and consumption:
Oral: a dose 4g, three times on the one.
Chinese medicine preparation of the present invention has tangible replenishing kidney-YIN, and the life essence-filling, marrow-benefitting effect is applicable to deficiency of the kidney yin and syndrome of deficiency of both yin and yang of kidney.Preparation technology is reasonable, the drug effect height, and composition is accurate, has to use easy to carryly, has no side effect, and is suitable for the advantage of patient to the different dosage form demand.
The specific embodiment
Embodiment one
The Chinese medicine of treatment deficiency of the kidney yin, deficiency syndrome of both YIN and YANG, sugar coated tablet:
Get Fructus Lycii 150g, Radix Polygoni Multiflori 150g, Semen sojae atricolor 150g, Fructus Mori 75g, Radix Puerariae 150g, Fructus Schisandrae Chinensis 75g, Fructus Corni 75g, Radix Ginseng 15g, Pheretima 75g, Cornu Cervi Pantotrichum 15g, scald Testis et Pentis Canis 20g, scald Ren Bovis seu Bubali 20g, Fructus Corni, Radix Ginseng, Cornu Cervi Pantotrichum, boiling hot Testis et Pentis Canis, boiling hot Ren Bovis seu Bubali are ground into fine powder, standby.Seven flavor medicines such as all the other Fructus Lycii decoct with water twice, add 10 times of water gagings for the first time, decoct two hours, filter; For the second time add 8 times of water gagings, decocted two hours, filter; Merging filtrate, be concentrated into the clear paste of relative density 1.30-1.35 (40-50 ℃ of survey), add above-mentioned medicated powder, mixing, in drying under reduced pressure below 70 ℃, pulverizing, mistake 100 mesh sieves, granulate with 10% starch slurry, drying adds 0.5% magnesium stearate of grain amount and 1% Pulvis Talci mixing, be pressed into 1000, every contains crude drug 0.97g, and sugar coating is made sugar coated tablet.
Embodiment two
The Chinese medicine of treatment deficiency of the kidney yin, deficiency syndrome of both YIN and YANG, film coated tablet:
Get Fructus Lycii 150g, Radix Polygoni Multiflori 150g, Semen sojae atricolor 150g, Fructus Mori 75g, Radix Puerariae 150g, Fructus Schisandrae Chinensis 75g, Fructus Corni 75g, Radix Ginseng 15g, Pheretima 75g, Cornu Cervi Pantotrichum 15g, scald Testis et Pentis Canis 20g, scald Ren Bovis seu Bubali 20g, Fructus Corni, Radix Ginseng, Cornu Cervi Pantotrichum, boiling hot Testis et Pentis Canis, boiling hot Ren Bovis seu Bubali are ground into fine powder, standby.Seven flavor medicines such as all the other Fructus Lycii decoct with water twice, add 10 times of water gagings for the first time, decoct two hours, filter; For the second time add 8 times of water gagings, decocted two hours, filter; Merging filtrate, be concentrated into the clear paste of relative density 1.30-1.35 (40-50 ℃ of survey), add above-mentioned medicated powder, mixing, in drying under reduced pressure below 70 ℃, pulverizing, mistake 100 mesh sieves, add calcium sulfate 11g, pregelatinized Starch 1.95g, microcrystalline Cellulose 3.3g, mixing is granulated with 12% syrup, dry, add the magnesium stearate of grain amount 0.5% and 1% Pulvis Talci mixing, be pressed into 1000, every contains crude drug 0.97g; Perhaps be pressed into 500, every contains crude drug 1.94g, and the bag film-coat is made two kinds of specification Film coated tablets.
Embodiment three
The Chinese medicine of treatment deficiency of the kidney yin, deficiency syndrome of both YIN and YANG, capsule:
Get Fructus Lycii 150g, Radix Polygoni Multiflori 150g, Semen sojae atricolor 150g, Fructus Mori 75g, Radix Puerariae 150g, Fructus Schisandrae Chinensis 75g, Fructus Corni 75g, Radix Ginseng 15g, Pheretima 75g, Cornu Cervi Pantotrichum 15g, scald Testis et Pentis Canis 20g, scald Ren Bovis seu Bubali 20g, Fructus Corni, Radix Ginseng, Cornu Cervi Pantotrichum, boiling hot Testis et Pentis Canis, boiling hot Ren Bovis seu Bubali are ground into fine powder, standby.Seven flavor medicines such as all the other Fructus Lycii decoct with water twice, add 10 times of water gagings for the first time, decoct two hours, filter; For the second time add 8 times of water gagings, decocted two hours, filter; Merging filtrate, be concentrated into the clear paste of relative density 1.30-1.35 (40-50 ℃ of survey), add above-mentioned medicated powder, mixing, in drying under reduced pressure below 70 ℃, pulverizing, mistake 100 mesh sieves, granulate with 13% starch slurry, drying adds the magnesium stearate of grain amount .5% and 1% Pulvis Talci mixing, be filled in the Capsules behind the granulate, make 1000 altogether, every contains crude drug 0.97g, makes capsule.
Embodiment four
The Chinese medicine of treatment deficiency of the kidney yin, deficiency syndrome of both YIN and YANG contains sugared granule:
Get Fructus Lycii 150g, Radix Polygoni Multiflori 150g, Semen sojae atricolor 150g, Fructus Mori 75g, Radix Puerariae 150g, Fructus Schisandrae Chinensis 75g, Fructus Corni 75g, Radix Ginseng 15g, Pheretima 75g, Cornu Cervi Pantotrichum 15g, scald Testis et Pentis Canis 20g, scald Ren Bovis seu Bubali 20g, Radix Ginseng, Pulveratum Cornu Cervi Pantotrichum are broken into fine powder, standby.Ten flavor medicines such as all the other Fructus Lycii decoct with water twice, add 10 times of water gagings for the first time, decoct two hours, filter; For the second time add 8 times of water gagings, decocted two hours, filter; Merging filtrate, being concentrated into relative density is the clear paste of 1.30-1.35 (40-50 ℃ of survey), the clear paste quantities received accounts for 33% of the material total amount of offeing medicine, and adds above-mentioned medicated powder, mixing, clear paste and the medicated powder of getting mixing add 4.7 parts of cane sugar powders for 1 part, mixing is made dried granule 1600g, is distributed into every bag of 8g, every bag is equivalent to crude drug 4.85g, makes to contain sugared granule.
Embodiment five
The Chinese medicine of treatment deficiency of the kidney yin, deficiency syndrome of both YIN and YANG, sugar free granule:
Get Fructus Lycii 150g, Radix Polygoni Multiflori 150g, Semen sojae atricolor 150g, Fructus Mori 75g, Radix Puerariae 150g, Fructus Schisandrae Chinensis 75g, Fructus Corni 75g, Radix Ginseng 15g, Pheretima 75g, Cornu Cervi Pantotrichum 15g, scald Testis et Pentis Canis 20g, scald Ren Bovis seu Bubali 20g, Radix Ginseng, Pulveratum Cornu Cervi Pantotrichum are broken into fine powder, standby.Ten flavor medicines such as all the other Fructus Lycii decoct with water twice.For the first time add 10 times of water gagings, decocted two hours, filter; For the second time add 8 times of water gagings, decocted two hours, filter; Merging filtrate, being concentrated into relative density is the clear paste of 1.30-1.35 (40-50 ℃ of survey), adds above-mentioned medicated powder, mixing in 70 ℃ of following drying under reduced pressure, is pulverized, cross 100 mesh sieves, the powder that gets dry extract, the best quantities received of dried cream powder accounts for 15% of medical material amount, get 1 part of dried cream powder, it is an amount of to add 1 portion of soluble starch, 0.8 part of dextrin, steviosin, mixing, make dried granule 400g, be distributed into every bag of 2g, be equivalent to crude drug 4.85g, make sugar free granule.
Embodiment six
The Chinese medicine of treatment deficiency of the kidney yin, deficiency syndrome of both YIN and YANG, oral mixture:
Get Fructus Lycii 75g, Radix Polygoni Multiflori 75g, Semen sojae atricolor 75g, Fructus Mori 38g, Radix Puerariae 75g, Fructus Schisandrae Chinensis 38g, Fructus Corni 38g, Radix Ginseng 8g, Pheretima 38g, Cornu Cervi Pantotrichum 8g, scald Testis et Pentis Canis 10g, scald Ren Bovis seu Bubali 10g.Radix Ginseng, Pulveratum Cornu Cervi Pantotrichum are broken into coarse powder; Pheretima, boiling hot Testis et Pentis Canis, boiling hot Ren Bovis seu Bubali section add 50 and spend Chinese liquor 500ml dipping secondaries, add 300ml the first time, and add 200ml the second time, and each 12 hours, merge steeping in wine liquid twice, filter, it is standby to get medicinal liquid; Medicinal residues and all the other seven flavor medicines decoct with water twice, add 8 times of water gagings at every turn, decoct 1.5 hours, merging filtrate filters, and being concentrated into relative density is the clear paste of 1.10-1.12 (60-70 ℃ of survey), add ethanol and make that to contain alcohol amount be 70%, stir evenly, left standstill 12 hours, filter, filtrate recycling ethanol adds above-mentioned steeping in wine liquid, sodium benzoate 5g, sucrose 100g to there not being the alcohol flavor, adding to steam stays water to 1000ml, stir evenly, be distributed into every bottle of 30ml or 100ml, make oral mixture.Oral, a 10ml, three times on the one.
Claims (9)
1. treat the Chinese medicine of deficiency of the kidney yin, deficiency syndrome of both YIN and YANG, it is characterized in that being mixed with tablet, granule, capsule and oral mixture by Fructus Lycii, Radix Polygoni Multiflori, Semen sojae atricolor, Fructus Mori, Radix Puerariae, Fructus Schisandrae Chinensis, Fructus Corni, Radix Ginseng, Pheretima, Cornu Cervi Pantotrichum, boiling hot Testis et Pentis Canis, boiling hot Ren Bovis seu Bubali and adjuvant, its prescription is Fructus Lycii 150g, Radix Polygoni Multiflori 150g, Semen sojae atricolor 150g, Fructus Mori 75g, Radix Puerariae 150g, Fructus Schisandrae Chinensis 75g, Fructus Corni 75g, Radix Ginseng 15g, Pheretima 75g, Cornu Cervi Pantotrichum 15g, scalds Testis et Pentis Canis 20g, scalds Ren Bovis seu Bubali 20g.
2. the Chinese medicine of treatment deficiency of the kidney yin according to claim 1, deficiency syndrome of both YIN and YANG, it is characterized in that described adjuvant, comprise starch, pregelatinized Starch, soluble starch, dextrin, magnesium stearate, Pulvis Talci, calcium sulfate, microcrystalline Cellulose, cane sugar powder, steviosin, sodium benzoate and distilled water.
3. the Chinese medicinal preparation method of treatment deficiency of the kidney yin according to claim 1, deficiency syndrome of both YIN and YANG, it is characterized in that getting Fructus Lycii 150g, Radix Polygoni Multiflori 150g, Semen sojae atricolor 150g, Fructus Mori 75g, Radix Puerariae 150g, Fructus Schisandrae Chinensis 75g, Fructus Corni 75g, Radix Ginseng 15g, Pheretima 75g, Cornu Cervi Pantotrichum 15g, scald Testis et Pentis Canis 20g, scald Ren Bovis seu Bubali 20g, with Fructus Corni, Radix Ginseng, Cornu Cervi Pantotrichum, scald Testis et Pentis Canis, scalding Ren Bovis seu Bubali, to be ground into fine powder standby, seven flavor medicines such as all the other Fructus Lycii decoct with water twice, add for the first time 10 times of water gagings, decocted two hours, and filtered; For the second time add 8 times of water gagings, decocted two hours, filter; Merging filtrate is concentrated into relative density and surveys in the time of 40-50 ℃ and be the clear paste of 1.30-1.35, adds above-mentioned medicated powder, mixing, in drying under reduced pressure below 70 ℃, pulverizing, mistake 100 mesh sieves, be prepared into Chinese medicine powder, in Chinese medicine powder, add appropriate amount of auxiliary materials and be mixed and made into tablet, capsule.
4. the Chinese medicinal preparation method of treatment deficiency of the kidney yin according to claim 3, deficiency syndrome of both YIN and YANG, it is characterized in that the Chinese medicine powder that is prepared into, granulate with the 5-15% starch slurry, dry, add the magnesium stearate of grain amount .5% and 1% Pulvis Talci mixing, be pressed into 1000, every contains crude drug 0.97g, sugar coating is made sugar coated tablet.
5. the Chinese medicinal preparation method of treatment deficiency of the kidney yin according to claim 3, deficiency syndrome of both YIN and YANG, it is characterized in that the Chinese medicine powder that is prepared into, add calcium sulfate 11g, pregelatinized Starch 1.95g, microcrystalline Cellulose 3.3g, mixing, granulate with the 8-15% syrup, drying adds the magnesium stearate of grain amount 0.5% and 1% Pulvis Talci mixing, be pressed into 1000, every contains crude drug 0.97g; Perhaps be pressed into 500, every contains crude drug 1.94g, and the bag film-coat is made Film coated tablets.
6. the Chinese medicinal preparation method of treatment deficiency of the kidney yin according to claim 3, deficiency syndrome of both YIN and YANG, the Chinese medicine powder that its feature is being prepared into, granulate with the 5-15% starch slurry, dry, add the magnesium stearate of grain amount .5% and 1% Pulvis Talci mixing, be filled in behind the granulate in the Capsules, make 1000 altogether, every contains crude drug 0.97g, makes capsule.
7. the Chinese medicinal preparation method of treatment deficiency of the kidney yin according to claim 3, deficiency syndrome of both YIN and YANG after it is characterized in that taking by weighing medical material by prescription, is broken into fine powder with Radix Ginseng, Pulveratum Cornu Cervi Pantotrichum, standby, ten flavor medicines such as all the other Fructus Lycii decoct with water twice, add 10 times of water gagings for the first time, decocted two hours, and filtered; For the second time add 8 times of water gagings, decocted two hours, filter; Merging filtrate, being concentrated into relative density surveys in the time of 40-50 ℃ and is the clear paste of 1.30-1.35, the best quantities received of clear paste accounts for 33% of the material total amount of offeing medicine, and adds above-mentioned medicated powder, mixing, clear paste and the medicated powder of getting mixing add 4.7 parts of cane sugar powders for 1 part, mixing is made dried granule 1600g, is distributed into every bag of 8g, every bag is equivalent to crude drug 4.85g, makes to contain sugared granule.
8. the Chinese medicinal preparation method of treatment deficiency of the kidney yin according to claim 7, deficiency syndrome of both YIN and YANG, it is characterized in that adding in the described clear paste medicated powder of described Radix Ginseng, Pulveratum Cornu Cervi Pantotrichum, mixing, in 70 ℃ of following drying under reduced pressure, pulverize, cross 100 mesh sieves, the powder that gets dry extract, the best quantities received of dried cream powder accounts for 15% of medical material amount, gets 1 part of dried cream powder, it is an amount of to add 1 portion of soluble starch, 0.8 part of dextrin, steviosin, mixing is made dried granule 400g, is distributed into every bag of 2g, be equivalent to crude drug 4.85g, make sugar free granule.
9. the Chinese medicinal preparation method of treatment deficiency of the kidney yin according to claim 3, deficiency syndrome of both YIN and YANG after it is characterized in that taking by weighing medical material by 1/2nd of prescription amount, is broken into coarse powder with Radix Ginseng, Pulveratum Cornu Cervi Pantotrichum; Pheretima, boiling hot Testis et Pentis Canis, boiling hot Ren Bovis seu Bubali section add 50 and spend Chinese liquor 500ml dipping secondaries, add 300ml the first time, and add 200ml the second time, and each 12 hours, merge steeping in wine liquid twice, filter, it is standby to get medicinal liquid; Medicinal residues and all the other seven flavor medicines decoct with water twice, add 8 times of water gagings at every turn, decoct 1.5 hours, merging filtrate filters, and is concentrated into relative density and surveys in the time of 60-70 ℃ and be the clear paste of 1.10-1.12, add ethanol and make that to contain alcohol amount be 70%, stir well, left standstill 12 hours, filter, filtrate recycling ethanol adds above-mentioned steeping in wine liquid, sodium benzoate 5g, sucrose 100g to there not being the alcohol flavor, adding to steam stays water to 1000ml, stir evenly, be distributed into every bottle of 30ml or 100ml, make oral mixture.
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| CN106389771A (en) * | 2016-11-11 | 2017-02-15 | 东莞市百替生物科技有限公司 | Traditional Chinese medicine composition for treating kidney qi deficiency and preparation method thereof |
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