CN101166527A - 用于治疗肥胖症和糖尿病以及其相关病况和用于治疗可通过增加血液glp-1含量改善的病况的组合疗法 - Google Patents

用于治疗肥胖症和糖尿病以及其相关病况和用于治疗可通过增加血液glp-1含量改善的病况的组合疗法 Download PDF

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CN101166527A
CN101166527A CNA2006800142701A CN200680014270A CN101166527A CN 101166527 A CN101166527 A CN 101166527A CN A2006800142701 A CNA2006800142701 A CN A2006800142701A CN 200680014270 A CN200680014270 A CN 200680014270A CN 101166527 A CN101166527 A CN 101166527A
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brs
dpp
agonist
inhibitor
glp
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楚志良
詹姆斯·N·伦纳德
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Arena Pharmaceuticals Inc
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Arena Pharmaceuticals Inc
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CNA2006800142701A 2005-04-27 2006-04-26 用于治疗肥胖症和糖尿病以及其相关病况和用于治疗可通过增加血液glp-1含量改善的病况的组合疗法 Withdrawn CN101166527A (zh)

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US67573005P 2005-04-27 2005-04-27
US60/675,730 2005-04-27

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CN101166527A true CN101166527A (zh) 2008-04-23

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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DOP2006000008A (es) * 2005-01-10 2006-08-31 Arena Pharm Inc Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
WO2008085888A1 (en) * 2007-01-05 2008-07-17 Arena Pharmaceuticals, Inc. G protein-coupled receptor and modulators thereof for the treatment of gaba-related neurological disorders including sleep-related disorders
EP2108960A1 (en) 2008-04-07 2009-10-14 Arena Pharmaceuticals, Inc. Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY
WO2011080276A1 (en) 2009-12-29 2011-07-07 Genfit Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative
GB201415598D0 (en) * 2014-09-03 2014-10-15 Univ Birmingham Elavated Itercranial Pressure Treatment
WO2017151728A1 (en) * 2016-03-01 2017-09-08 Board Of Supervisors Of Louisiana State Univ. And Agricultural And Mechanical College Indirect assessment of insulin release in a cell
KR20210149366A (ko) * 2020-06-02 2021-12-09 주식회사 고바이오랩 Icam-2에 결합하는 물질을 유효성분으로 포함하는 대사질환 예방 또는 치료용 약학 조성물

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US5462856A (en) 1990-07-19 1995-10-31 Bunsen Rush Laboratories, Inc. Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins
US6100042A (en) 1993-03-31 2000-08-08 Cadus Pharmaceutical Corporation Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
GB9719496D0 (en) 1997-09-13 1997-11-19 Glaxo Group Ltd G protien chimeras
EP1123391A2 (en) 1998-09-01 2001-08-16 BASF Aktiengesellschaft Methods for improving the function of heterologous g protein-coupled receptors
GB0006289D0 (en) 2000-03-15 2000-05-03 Smithkline Beecham Plc New use
EP1364024A2 (en) 2000-11-27 2003-11-26 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human g protein-coupled receptors
DE10224844A1 (de) 2002-06-05 2004-01-08 Solvay Pharmaceuticals Gmbh Nicht-peptidische BRS-3-Agonisten
MXPA05007485A (es) 2003-01-14 2006-01-30 Arena Pharm Inc Derivados de arilo y heteroarilo 1,2,3-trisubstituidos como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con ello tales como diabetes e hiperglicemia.
EP1620555A4 (en) 2003-04-18 2006-09-13 Merck & Co Inc BOMBESIN RECEPTOR SUBTYP-3 (BRS-3) FROM RHESUS APPLE, SUCH NUCLEOTIDES AND USES THEREOF
PE20050948A1 (es) 2003-09-09 2005-12-16 Japan Tobacco Inc Compuestos de carbamoil-amina como inhibidores de la dipeptidil peptidasa iv
DOP2006000008A (es) 2005-01-10 2006-08-31 Arena Pharm Inc Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1

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US20130078649A1 (en) 2013-03-28
US9182414B2 (en) 2015-11-10
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WO2007027225A2 (en) 2007-03-08
JP2015120749A (ja) 2015-07-02
JP2008540336A (ja) 2008-11-20
US20090297537A1 (en) 2009-12-03
WO2007027225A3 (en) 2007-11-22
US8354241B2 (en) 2013-01-15
CA2605228A1 (en) 2007-03-08
EP1871362A2 (en) 2008-01-02
AU2006285393A1 (en) 2007-03-08

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