CA2605228A1 - Combination therapy for the treatment of obesity and diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level - Google Patents

Combination therapy for the treatment of obesity and diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level Download PDF

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Publication number
CA2605228A1
CA2605228A1 CA002605228A CA2605228A CA2605228A1 CA 2605228 A1 CA2605228 A1 CA 2605228A1 CA 002605228 A CA002605228 A CA 002605228A CA 2605228 A CA2605228 A CA 2605228A CA 2605228 A1 CA2605228 A1 CA 2605228A1
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Canada
Prior art keywords
dpp
agonist
brs
inhibitor
glp
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CA002605228A
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English (en)
French (fr)
Inventor
Zhi-Liang Chu
James N. Leonard
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Arena Pharmaceuticals Inc
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Individual
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Publication of CA2605228A1 publication Critical patent/CA2605228A1/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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  • Proteomics, Peptides & Aminoacids (AREA)
CA002605228A 2005-04-27 2006-04-26 Combination therapy for the treatment of obesity and diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood glp-1 level Withdrawn CA2605228A1 (en)

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Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DOP2006000008A (es) * 2005-01-10 2006-08-31 Arena Pharm Inc Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
WO2008085888A1 (en) * 2007-01-05 2008-07-17 Arena Pharmaceuticals, Inc. G protein-coupled receptor and modulators thereof for the treatment of gaba-related neurological disorders including sleep-related disorders
EP2108960A1 (en) 2008-04-07 2009-10-14 Arena Pharmaceuticals, Inc. Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY
WO2011080276A1 (en) 2009-12-29 2011-07-07 Genfit Pharmaceutical combinations comprising a dpp-4 inhibitor and a 1,3-diphenylprop-2-en-1-one derivative
GB201415598D0 (en) * 2014-09-03 2014-10-15 Univ Birmingham Elavated Itercranial Pressure Treatment
WO2017151728A1 (en) * 2016-03-01 2017-09-08 Board Of Supervisors Of Louisiana State Univ. And Agricultural And Mechanical College Indirect assessment of insulin release in a cell
KR20210149366A (ko) * 2020-06-02 2021-12-09 주식회사 고바이오랩 Icam-2에 결합하는 물질을 유효성분으로 포함하는 대사질환 예방 또는 치료용 약학 조성물

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
US4256108A (en) 1977-04-07 1981-03-17 Alza Corporation Microporous-semipermeable laminated osmotic system
US4265874A (en) 1980-04-25 1981-05-05 Alza Corporation Method of delivering drug with aid of effervescent activity generated in environment of use
US5462856A (en) 1990-07-19 1995-10-31 Bunsen Rush Laboratories, Inc. Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins
US6100042A (en) 1993-03-31 2000-08-08 Cadus Pharmaceutical Corporation Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
GB9719496D0 (en) 1997-09-13 1997-11-19 Glaxo Group Ltd G protien chimeras
EP1123391A2 (en) 1998-09-01 2001-08-16 BASF Aktiengesellschaft Methods for improving the function of heterologous g protein-coupled receptors
GB0006289D0 (en) 2000-03-15 2000-05-03 Smithkline Beecham Plc New use
EP1364024A2 (en) 2000-11-27 2003-11-26 Arena Pharmaceuticals, Inc. Endogenous and non-endogenous versions of human g protein-coupled receptors
DE10224844A1 (de) 2002-06-05 2004-01-08 Solvay Pharmaceuticals Gmbh Nicht-peptidische BRS-3-Agonisten
MXPA05007485A (es) 2003-01-14 2006-01-30 Arena Pharm Inc Derivados de arilo y heteroarilo 1,2,3-trisubstituidos como moduladores del metabolismo y la profilaxis y tratamiento de trastornos relacionados con ello tales como diabetes e hiperglicemia.
EP1620555A4 (en) 2003-04-18 2006-09-13 Merck & Co Inc BOMBESIN RECEPTOR SUBTYP-3 (BRS-3) FROM RHESUS APPLE, SUCH NUCLEOTIDES AND USES THEREOF
PE20050948A1 (es) 2003-09-09 2005-12-16 Japan Tobacco Inc Compuestos de carbamoil-amina como inhibidores de la dipeptidil peptidasa iv
DOP2006000008A (es) 2005-01-10 2006-08-31 Arena Pharm Inc Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1

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US20130078649A1 (en) 2013-03-28
US9182414B2 (en) 2015-11-10
JP2012136554A (ja) 2012-07-19
WO2007027225A2 (en) 2007-03-08
JP2015120749A (ja) 2015-07-02
JP2008540336A (ja) 2008-11-20
US20090297537A1 (en) 2009-12-03
WO2007027225A3 (en) 2007-11-22
US8354241B2 (en) 2013-01-15
EP1871362A2 (en) 2008-01-02
AU2006285393A1 (en) 2007-03-08
CN101166527A (zh) 2008-04-23

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