CN101156877A - A sobering-up agent - Google Patents
A sobering-up agent Download PDFInfo
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- CN101156877A CN101156877A CNA2007100307414A CN200710030741A CN101156877A CN 101156877 A CN101156877 A CN 101156877A CN A2007100307414 A CNA2007100307414 A CN A2007100307414A CN 200710030741 A CN200710030741 A CN 200710030741A CN 101156877 A CN101156877 A CN 101156877A
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Abstract
The invention relates to a Chinese drug health product, in particular to a Chinese drug antialcoholic health product. The antialcoholic drug of the invention uses the extractive of coriolus versicolor polysaccharide as the main raw material, and also the extractive of hericium erinaceus polysaccharide and the extractive of cordyceps sinensis polysaccharide can be added. By adding pharmaceutically acceptable auxiliary material, the antialcoholic drug of the invention can be produced into capsules, tablets, granules or oral liquid and beverage, etc. The antialcoholic drug of the invention can protect liver, nourish the stomach, detoxicate, and favor the five parenchymatous viscera. In addition, by taking the antialcoholic drug of the invention, an alcohol drinker can quickly get rid of symptoms of headache, and nausea, and can recover to the ordinary state in a short time.
Description
Technical field
The present invention relates to a kind of Chinese medicine health care product, particularly a kind of Chinese medicine preparation that the liver-protecting and alcoholism-relieving effect is arranged.
Background technology
Spirits culture has its unique status as a kind of special form of culture in traditional Chinese culture.In civilized history in several thousand, wine almost is penetrated into the every field in the society.Yet transition is drunk and also can be caused disease, from ancient times to the present dies to be difficult to counting in the wine patient.Excessive consumption of alcohol has brought great misery to people, and hypertension is lured in excessive consumption of alcohol into, easily inspires rupture of blood vessel in brain generation cerebral hemorrhage and subarachnoid hemorrhage; Drink for a long time and insobriety all the liver stomach function regulating is caused great injury, easily bring out liver cirrhosis, fatty liver; Drinking, the back is also dizzy easily, vomiting, drives when intoxicated and has brought great hidden danger for especially the safety of personal property.People were once relieved the effect of alcohol by several different methods for a long time, as: with acetolysis wine, drink tea, take and separate the drinks health product, or the like, yet often effect is all not obvious.
Summary of the invention
The invention provides a kind of Medicament for Alcoholism, particularly a kind of to after drinking dizzy, feel sick, Medicament for Alcoholism that frequent micturition etc. has good result.
Medicament for Alcoholism of the present invention, its primary raw material and parts by weight thereof are: krestin extract 65-80 part.
In order further to heighten the effect of a treatment, can also in said components, increase into the Hericium Erinaceus Polysaccharide extract, the parts by weight of described Hericium Erinaceus Polysaccharide extract are 10-20 part.
In order further to heighten the effect of a treatment, can also in said components, increase into the Cordyceps polysaccharide extract, the parts by weight of described Cordyceps polysaccharide extract are 10-20 part.
Medicament for Alcoholism of the present invention, after krestin extract, Hericium Erinaceus Polysaccharide extract, three kinds of raw materials of Cordyceps polysaccharide extract mixed, the ratio of weight and number of active ingredient was in the mixture, krestin 20-35 part, Cordyceps polysaccharide 5-18 part, Hericium Erinaceus Polysaccharide 5-15 part.
In order further to heighten the effect of a treatment, can also in said components, increase into Fructus Lycii extract or/and Semen Cuscutae extract Huo/with the peppery element of Ginger.
Medicament for Alcoholism of the present invention, in the raw mix, the parts by weight of Fructus Lycii extract, the peppery element of Semen Cuscutae extract, Ginger are: Fructus Lycii extract 3-8 part, Semen Cuscutae extract 3-8 part, Fructus Lycii extract 3-8 part.
Be aided with acceptable accessories, Medicament for Alcoholism of the present invention can be made capsule, tablet, granule or oral liquid.
Medicament for Alcoholism of the present invention is raw materials used, and the content of krestin is not less than 50% in the krestin extract; The content of Hericium Erinaceus Polysaccharide is not less than 50% in the Hericium Erinaceus Polysaccharide extract; The content of Cordyceps polysaccharide is not less than 45% in the Cordyceps polysaccharide extract.
Its raw material polysaccharide of Medicament for Alcoholism of the present invention is taken from medicinal fungi or edible fungi.Its compound basis is:
Coriolous Dersicolor (Fr.) Quel: China is among the people to utilize it to treat some chronic disease very early.As asthma, hepatopathy etc.Coriolous Dersicolor (Fr.) Quel is for the liver protecting positive effect.The effect of report krestin energy enhancing human body immunity power and inhibition tumor is more arranged in recent years.
Cordyceps: the effect of useful guarantor's lung, secret quiet suitable gas, hemostasisization disease, can control weakness, building body, the effect of tranquillizing and allaying excitement.
Hericium erinaceus (Bull. Ex Fr.) Pers.: have sharp the five internal organs, digestant effect, for dyspepsia, chronic gastritis, duodenal ulcer, the neurasthenia, physical weakness has curative effect preferably.
The preparation of krestin extract:
The first-class Coriolous Dersicolor (Fr.) Quel of first screening, washing, drying is pulverized then, and reuse water extraction krestin promptly is being incubated 90min below 110 ℃, and then filter and remove residue, at vacuum concentrated filtrate below 70 ℃, dusts again, obtains Powdered extract; Detect persticide residue and heavy metal amount, take persticide residue and content of beary metal in GB with interior extract; Detect polysaccharide concentration,, make krestin concentration greater than 50% if polysaccharide concentration less than 50%, is then further used alcohol extraction.
Perhaps directly purchase the krestin extract that meets above-mentioned examination criteria from the market.
Cordyceps polysaccharide and Hericium Erinaceus Polysaccharide all are with its mycelium fermentation broth of water extraction, the extracting method of its extracting method such as above-mentioned krestin extract; The Cordyceps polysaccharide extract that extracts and its persticide residue of Hericium Erinaceus Polysaccharide extract and content of beary metal also all will be in national standards, finally obtain concentration in the Cordyceps polysaccharide extract more than 45% and concentration at the Hericium Erinaceus Polysaccharide extract more than 40%.
Perhaps purchase Cordyceps polysaccharide extract and the Hericium Erinaceus Polysaccharide extract that meets above-mentioned examination criteria from the market.
The peppery element of the Fructus Lycii extract of medicinal standard, Semen Cuscutae extract and a kind of sedge can directly be purchased from the market.
Medicament for Alcoholism of the present invention is that the polysaccharide with fungus and edible fungi is an effective ingredient, but polysaccharide human body immunity improving function and reach the purpose of preventing and curing diseases, almost be free from side effects, particularly more can reach disease-prevention health, improve the effect of body function (liver function) chronic alcoholism (long-term alcohol user).Krestin has better curative effect for prevention, treatment hepatopathy pneumonopathy, and the function of detoxification of Coriolous Dersicolor (Fr.) Quel, more can protect body to avoid the infringement of ethanol.Hericium erinaceus (Bull. Ex Fr.) Pers. nourishing the stomach especially, protect the good medicine of stomach.The diuresis of Fructus Lycii hepatoprotective, Semen Cuscutae is good for kidney, the peppery plain warming middle-JIAO for easing the stomach of a kind of sedge.So Medicament for Alcoholism of the present invention, hepatoprotective, nourishing the stomach, detoxifcation, sharp the five internal organs, and, take Medicament for Alcoholism of the present invention, the drunk symptom that the alcohol user breaks away from headache soon, feels sick can return to normal within a short period of time.More there is relevant experimental check to prove the good action of antialcoholic drug of the present invention in an embodiment for aspects such as the liver protecting stomach function regulating.
Specify Medicament for Alcoholism of the present invention below in conjunction with embodiment, but can not limit scope of the present invention with this, the variation of making according to essence of the present invention still belongs to protection scope of the present invention.
Figure of description
Figure 1A is the 15th day Chinese medicine A group of test mouse liver pathological section figure in the protection test of alcoholic liver injury;
Figure 1B is the 15th day Chinese medicine B group of test mouse liver pathological section figure in the protection test of alcoholic liver injury;
Fig. 1 C is the 15th day Chinese medicine C group of test mouse liver pathological section figure in the protection test of alcoholic liver injury;
Fig. 1 D is that the 15th day Chinese liquor of test is irritated stomach mice group hepatic pathology slice map in the protection test of alcoholic liver injury;
Fig. 1 E is the 15th day normal group mouse liver pathological section figure of test in the protection test of alcoholic liver injury;
Fig. 2 A is the 30th day Chinese medicine A group of test mouse liver pathological section figure in the protection test of alcoholic liver injury;
Fig. 2 B is the 30th day Chinese medicine B group of test mouse liver pathological section figure in the protection test of alcoholic liver injury;
Fig. 2 C is the 30th day Chinese medicine C group of test mouse liver pathological section figure in the protection test of alcoholic liver injury;
Fig. 2 D is that the 30th day Chinese liquor of test is irritated stomach mice group hepatic pathology slice map in the protection test of alcoholic liver injury;
Fig. 2 E is the 30th day normal group mouse liver pathological section figure of test in the protection test of alcoholic liver injury.
The specific embodiment
Embodiment one
(1) preparation of raw material polyoses extract
The preparation of krestin:
The first-class Coriolous Dersicolor (Fr.) Quel of first screening, washing, drying is pulverized then, and reuse water extraction krestin promptly is being incubated 90min below 110 ℃, and then filter and remove residue, at vacuum concentrated filtrate below 70 ℃, dusts again, obtains Powdered extract; Detect persticide residue and heavy metal amount, take persticide residue and heavy metal amount in GB with interior extract; Detect polysaccharide concentration,, make krestin concentration greater than 50% if polysaccharide concentration less than 50%, is then further used alcohol extraction.
Cordyceps polysaccharide and Hericium Erinaceus Polysaccharide all are with its mycelium fermentation broth of water extraction, the extracting method of its extracting method such as above-mentioned krestin; The Cordyceps polysaccharide that extracts and its pesticide residues of Hericium Erinaceus Polysaccharide and heavy metal amount also all will be in national standards, finally obtain concentration in the Cordyceps polysaccharide extract more than 45% and concentration at the Hericium Erinaceus Polysaccharide extract more than 40%.
(2) preparation of raw mix
Get 65 parts of the krestin extracts of above-mentioned preparation, 20 parts of Cordyceps polysaccharide extracts, 15 parts of Hericium Erinaceus Polysaccharide extracts, mix homogeneously is prepared into raw mix one.
Perhaps use 20 parts of 70 parts of krestin extracts and HOUTOUGU polyoses extracts, mix homogeneously is made raw mix two.
Perhaps use 100 parts of krestin extracts, be raw mix three.
(3) preparation of capsule
The raw mix of above-mentioned preparation (can select mixture one, two or three for use), dress is made capsule according to quantity, the sealing storage.When taking according to the once oral 1-3g of effective dose, can be according to drunk degree different choice taking dose.
(4) preparation of tablet
The above-mentioned raw mix for preparing (can select mixture one, two or three for use) adds pharmaceutically acceptable pharmaceutic adjuvant, and raw mix/pharmaceutic adjuvant is pressed into tablet by commonsense method then about 7/3.Tablet, every 1-1.2g is preferably in and takes before drinking, and each oral 1, also can add 2 according to drunk degree.
(5) preparation of granule
With the above-mentioned raw mix for preparing (can select mixture one, two or three for use); add pharmaceutically acceptable pharmaceutic adjuvant; as dextrin, flavoring agent; essence or the like; also can add the adjuvants such as taurine that have the refreshment effect in right amount; be about 4/6 with raw mix/pharmaceutic adjuvant, make dissolved granule according to commonsense method.
Embodiment two
Purchasing krestin content from the market is not less than 50% krestin extract, Cordyceps polysaccharide content and is not less than 45% Cordyceps polysaccharide extract, Hericium Erinaceus Polysaccharide content and is not less than 50% Hericium Erinaceus Polysaccharide extract.It is standby that preparation meets the peppery element of Fructus Lycii extract, Semen Cuscutae extract and a kind of sedge of medicinal standard.
Above-mentioned ready three kinds of polyoses extracts are mixed in right amount, make holosaccharide content in the mixed mixture: 30 parts of krestins, 10 parts of Cordyceps polysaccharides, 10 parts of Hericium Erinaceus Polysaccharide; The mixture mix homogeneously.Add an amount of peppery element of Fructus Lycii extract, Semen Cuscutae extract and a kind of sedge as required, and mix homogeneously.
The preparation of oral liquid:
With above-mentioned mixed raw materials mixture is original material, is prepared into oral liquid or health beverage according to commonsense method.Below be a kind of common preparation method:
Raw mix is prepared into water saturation solution, filter described water saturation solution, available room temperature pressure filtration method obtains filtrate, and the reuse pure water dilutes described filtrate and obtains product stock solution, described product stock solution total sugar amount after the dilution is about 20%, add the flavoring agent of a small amount of various tastes when needing, the packing that sterilizes then, sterilization, make beverage, as beverage, oral liquid etc.Select taking dose according to drunk degree when taking, also can do at ordinary times health promoting beverage and drink.
Embodiment three
The rat peroral acute toxicity test
20 of SD rats, male and female half and half are diluted to 1% solution (being that every 1mL contains the 10mg dose) with Chinese medicine stock solution respectively with distilled water and irritate stomach with the dosage of 2ml/100g, repeat once after four hours, observe 15 days, and experimental animal all has no adverse reaction, and does not have dead.Antialcoholism capsule of the present invention in view of the above (by the raw content thing) LD
50>20000mg/kg belongs to nontoxic level by the food toxicity grading.
Embodiment four
Medicament for Alcoholism of the present invention is applicable to that the personage after drinking of any age bracket uses, and following material is the result of use analysis of data of Medicament for Alcoholism of the present invention:
40 drunk persons (wherein 20-24 year 28 people, 39-46 year 12 people) are carried out the result of use analysis.Wherein 40 drunk persons all in various degree giddy is arranged, drunk symptom such as feel sick.40 drunk persons are taken antialcoholism capsule of the present invention simultaneously.Take 3, i.e. the 0.6g effective dose at every turn.
Feedback result:
1,25 people do not have drunk phenomenon after taking; After taking, 12 people do not have hangover phenomenon; 5 people are significantly improved taking Medicament for Alcoholism aftersensation capacity for liquor of the present invention; 1 people represents there is not positive effect.
2, there are 30 people taking 20 minutes aftersensations of Medicament for Alcoholism of the present invention, have 8 people taking 30 minutes aftersensations of Medicament for Alcoholism of the present invention to drug effect to drug effect; There are 2 people to take 45 minutes aftersensations of Medicament for Alcoholism of the present invention to drug effect.
Toxic and side effects and untoward reaction:
Detect for 40 experimenters chemical examination before and after test, routine urinalysis, liver function is analysed survey, and is all no abnormal.The experimenter does not feel to have any discomfort reaction yet.
Embodiment four
The protection test of alcoholic liver injury
In order to estimate the protection effect of three kinds of Sobering-up Chinese medicines in objective science ground to alcoholic liver injury; adopt Chinese liquor that white mice was irritated stomach in continuous 30 days and bring out the alcoholic liver injury model; and carry out the drink-service administration with three kinds of Sobering-up Chinese medicines simultaneously; ALT, AST and MDA, GSH and histopathology detection are carried out in sampling in the time of the 10th, 20 and 30 day, have verified the prevention effect to alcoholic liver injury.
1. materials and methods
1.1 trial drug and reagent
Three kinds of Sobering-up Chinese medicine solution are provided by the precious health food company limited of Guangzhou treasured, are denoted as A, B and C respectively.A is a krestin solution; B is Cordyceps polysaccharide+krestin+Hericium Erinaceus Polysaccharide mixed solution; C is krestin+Hericium Erinaceus Polysaccharide solution.
MDA (malonaldehyde) and GSH (reduced glutathion) adopt dedicated kit to detect, and building up bio-engineering research by Nanjing is provided; ALT (alanine aminotransferase) and AST (aspartate amino transferase) are measured by the automatic biochemical detecting instrument.
1.2 experimental animal and reagent
Choose healthy ♂ white mice, 120, body weight 22-28g adapts to and raised for 1 week.Be divided into 5 groups at random: A, B, three Sobering-up Chinese medicine groups of C, Chinese liquor are irritated stomach group, normal group.Grouping and administration see Table 1.Chinese medicine stock solution is diluted to 1% solution (being that every 1mL contains the 10mg dose) respectively with distilled water, by the drink-service of every Mus 0.5mg every day dose.
Table 1 grouping and administration
Group number | Group | Animal | Administering mode |
1 | A | 24 | Irritate wine every day, with Chinese medicine A solution dilution by the 0.5mg/ administration of only drinking water every day |
2 | B | 24 | Irritate wine every day, with Chinese medicine B solution dilution by the 0.5mg/ administration of only drinking water every day |
3 | C | 24 | Irritate wine every day, with Chinese medicine C solution dilution by the 0.5mg/ administration of only drinking water every day |
4 | Chinese liquor is irritated the stomach group | 24 | Irritate not administration of wine |
5 | Normal group | 24 | Do not irritate wine, not administration |
1.3 bring out the alcoholic liver injury method
56 ° of Beijing Red Star Erguotou wines are standby with the Chinese liquor that distilled water is mixed with spirituosity 40% (v/v).Except that normal group, each group is all irritated stomach by 9mL/kg in first week, irritates the stomach amount from second week to the 30th day Chinese liquor and reduces by half (4.5mL/kg), and irritate stomach once between 9:00-10:00 morning every day.
1.4 sampling and mensuration:
, select 6 white mice to put to death at random, gather blood 1-2mL (preparation serum) and liver organization for every group in the time of the 10th, 20 and 30 day in test.Hepatic tissue grinds with glass homogenizer under 0-4 ℃, centrifugal 10 minutes of 10000rpm, and getting supernatant and serum one, to arise from-20 ℃ of preservations standby.Pressing bio-chemical detector and test kit description measures.
The liver that all test group each group in the time of the 15th, 30 day is got 2 Mus carries out check pathological section.
1.5 statistical procedures: adopt variance analysis, the t method of inspection.
2. result
2.1 middle drug solns is to the influence of the AST and the ALT of alcoholic liver injury mouse serum
2.1.1 when testing the 10th day, what each organized the AST (aspartate amino transferase) of mouse serum and ALT (alanine aminotransferase) the results are shown in Table 2,3.The result shows, with normal group relatively, the AST that Chinese liquor is irritated stomach group and A, C Chinese drug-treated group significantly raise (p<0.05), though and Chinese medicine B group AST has rising, but be starkly lower than other test group, show in the time of the 10th day, Chinese medicine B group is better than Chinese medicine A and C on the serum AST index that reduces alcoholic liver injury.Aspect Serum ALT, Chinese medicine B group also is better than Chinese medicine A and C to reducing the ALT index.
2.1.2 when testing the 20th day, what each organized the AST of mouse serum and ALT the results are shown in Table 4,5.In the time of the 20th day, the result shows that Chinese medicine B group all is better than Chinese medicine A and C to reducing serum AST and ALT two aspects in test.Chinese medicine A effect is relatively poor.
2.1.3 when testing the 30th day, what each organized the AST of mouse serum and ALT the results are shown in Table 6,7.When testing the 30th day, along with the prolongation of administration time, Chinese medicine A, B, C all show good reduction serum AST and ALT effect, and wherein Chinese medicine B and C are close, and Chinese medicine A effect is relatively poor.
AST changes of contents unit: U/L in the mouse serum is respectively organized in table 2 test in the time of the 10th day
Sample | The A group | The B group | The C group | The wine group | Normal group |
1 | 96.57 | 156.3 | --- | 192.3 | 97.08 |
2 | 199.1 | 216.7 | 162.4 | 154 | 221.1 |
3 | 262.3 | 208 | 147.7 | 211.4 | 159.7 |
4 | 187.1 | 134.7 | 293.3 | 139.9 | 77.33 |
5 | 219.2 | 124.1 | 168.9 | 300.4 | 102.0 |
6 | 195.9 | 66.53 | 114.1 | 100.2 | 178.6 |
Average | 193.36 | 151.06 | 177.28 | 183.03 | 139.30 |
Standard deviation | 54.53 | 56.07 | 68.23 | 69.61 | 55.97 |
ALT changes of contents unit: U/L in the mouse serum is respectively organized in table 3 test in the time of the 10th day
Sample | The A group | The B group | The C group | The wine group | Normal group |
1 | 51.99 | 42.94 | 40.92 | 60.7 | 68.27 |
2 | 80.53 | 41.33 | 48.1 | 26.61 | 16.47 |
3 | 33.24 | 56.62 | 53.85 | 105.1 | 61.22 |
4 | 48.47 | 37.4 | 47.93 | 34.73 | 30.7 |
5 | 60.33 | 44.84 | 51.68 | 31.13 | 63.27 |
6 | 52.35 | 37.49 | 43.25 | 59.07 | 61.39 |
Average | 54.49 | 43.44 | 47.62 | 52.89 | 50.22 |
Standard deviation | 15.56 | 7.10 | 4.89 | 29.39 | 21.27 |
AST changes of contents unit: U/L in the mouse serum is respectively organized in table 4 test in the time of the 20th day
Sample | The A group | The B group | The C group | The wine group | Normal group |
1 | 258.4 | 152.7 | 237.2 | 184.3 | 218.1 |
2 | 291.1 | 231.4 | 226.0 | 365.3 | 142 |
3 | 187.7 | 242.6 | 167.0 | 191.1 | 149.1 |
4 | 138.7 | 193.0 | 390.0 | 231.0 | 182.7 |
5 | 294.1 | 230.7 | 180.9 | 288.7 | 218.1 |
6 | 520.1 | 122.3 | 196.3 | 213.5 | 234.2 |
Average | 281.68 | 195.45 | 232.90 | 245.65 | 190.70 |
Standard deviation | 131.84 | 48.87 | 81.40 | 69.51 | 38.88 |
ALT changes of contents unit: U/L in the mouse serum is respectively organized in table 5 test in the time of the 20th day
Sample | The A group | The B group | The C group | The wine group | Normal group |
1 | 90.63 | 47.68 | 59.35 | 43.6 | 60.47 |
2 | 53.13 | 62.45 | 58.73 | 187.3 | 39.57 |
3 | 19.11 | 63.34 | 39.2 | 46.08 | 41.71 |
4 | 54.35 | 42.71 | --- | 60.98 | 33.12 |
5 | 28.51 | ---- | 48.73 | 35.79 | 59.5 |
6 | 184.8 | 48.92 | 49.56 | 68.82 | 29.65 |
Average | 71.76 | 53.02 | 51.11 | 73.76 | 44.00 |
Standard deviation | 60.71 | 9.31 | 8.30 | 56.92 | 13.12 |
AST changes of contents unit: U/L in the mouse serum is respectively organized in table 6 test in the time of the 30th day
Sample | The A group | The B group | The C group | The wine group | Normal group |
1 | 255.8 | 233.5 | 187.0 | 346.0 | 215.0 |
2 | 240.4 | 197.9 | 281.8 | 382.4 | 270.6 |
3 | 314.7 | 250.0 | 234.4 | 303.8 | 185.1 |
4 | 281.2 | 168.9 | 206.1 | 294.2 | 192.3 |
5 | 344.9 | 240.8 | 279.8 | 268.2 | 289.6 |
6 | 251.5 | 353.5 | 213.7 | 362.6 | 267.3 |
Average | 281.42 | 240.77 | 233.80 | 326.20 | 236.65 |
Standard deviation | 40.92 | 63.01 | 39.45 | 44.19 | 44.70 |
ALT changes of contents unit: U/L in the mouse serum is respectively organized in table 7 test in the time of the 30th day
Sample | The A group | The B group | The C group | The wine group | Normal group |
1 | 66.84 | 56.98 | 75.72 | 132.7 | 81.66 |
2 | 66.4 | 50.3 | 65.94 | 182.0 | 85.20 |
3 | 87.72 | 64.52 | 68.29 | 102.3 | 56.44 |
4 | 76.81 | 48.45 | 58.75 | 132.4 | 62.63 |
5 | 70.2 | 79.97 | 80.26 | 115.6 | 87.65 |
6 | 51.11 | 69.25 | 56.18 | 129.3 | 77.38 |
Average | 69.85 | 61.58 | 67.52 | 132.38 | 75.16 |
Standard deviation | 12.17 | 12.05 | 9.36 | 27.05 | 12.74 |
2.2 middle drug solns is to the influence of alcoholic liver injury white mice liver and serum MDA (malonaldehyde) content
2.2.1 when testing the 10th day, each organizes the white mice liver and Content of MDA the results are shown in Table 8,9.Compare with normal group, the liver MDA content that Chinese liquor is irritated stomach group and Chinese medicine A, B group obviously raises, and the liver MDA of Chinese medicine C group is starkly lower than other test group and significant difference (p<0.05); Aspect Content of MDA, three Chinese drug-treated group and Chinese liquor are irritated stomach group comparing difference not obvious (p>0.05), show in the time of the 10th day, Chinese medicine C group reduce the liver radical damage aspect be better than Chinese medicine A and B.
2.2.2 when testing the 20th day, each organizes the white mice liver and Content of MDA the results are shown in Table 10,11.The result shows that the liver MDA of Chinese medicine C group is starkly lower than other test group and significant difference (p<0.05), and is close with normal group; On the Content of MDA index, reflected that Chinese medicine A, B, C group all have tangible reduction effect of free radicals damage, irritate the poor heteropole of stomach group significantly (p<0.01) with Chinese liquor.
2.2.3 when testing the 30th day, each organizes the white mice liver and Content of MDA the results are shown in Table 12,13.When testing the 30th day, along with the prolongation of administration time, Chinese medicine A, B, C all show good reduction liver and Content of MDA, show that Chinese medicine A, B, C all have the liver of reduction effect of free radicals damage.
White mice liver MDA content unit: nmol/ml is respectively organized in table 8 test in the time of the 10th day
Sample | The A group | The B group | The C group | The wine group | Normal group |
1 | 29.704 | 15.231 | 9.176 | 30.681 | 16.393 |
2 | 18.812 | 20.522 | 13.226 | 19.778 | 15.798 |
3 | 16.647 | 42.944 | 14.040 | 21.691 | 7.705 |
4 | 22.017 | 22.528 | 13.269 | 12.269 | 7.705 |
5 | 19.587 | 17.547 | 14.933 | 18.307 | 13.546 |
6 | 15.809 | 10.049 | 15.375 | 25.481 | 38.443 |
Average | 20.43 | 21.47 | 13.34 | 21.37 | 16.60 |
Standard deviation | 5.05 | 11.38 | 2.21 | 6.30 | 11.36 |
Mouse serum MDA content unit: nmol/ml is respectively organized in table 9 test in the time of the 10th day
Sample | The A group | The B group | The C group | The wine group | Normal group |
1 | 19.734 | 18.040 | 23.356 | 25.385 | 12.040 |
2 | 17.043 | 12.990 | -- | 14.518 | 18.239 |
3 | 22.379 | 18.771 | 21.233 | -- | 14.799 |
4 | 16.287 | -- | 15.367 | 18.106 | 18.771 |
5 | 18.321 | 24.219 | 19.435 | 21.673 | 16.879 |
6 | --- | 13.455 | 15.714 | 24.388 | 13.588 |
Average | 18.75 | 17.50 | 19.02 | 20.81 | 15.72 |
Standard deviation | 2.41 | 4.58 | 3.47 | 4.51 | 2.68 |
White mice liver MDA content unit: nmol/ml is respectively organized in table 10 test in the time of the 20th day
Sample | The A group | The B group | The C group | The wine group | Normal group |
1 | 12.540 | 26.754 | 12.080 | 29.999 | 10.855 |
2 | 31.315 | 14.739 | 12.273 | 9.667 | 7.041 |
3 | 16.066 | 17.946 | 18.952 | 9.655 | 15.518 |
4 | 13.415 | 20.074 | 11.077 | 39.817 | 6.868 |
5 | 13.805 | 16.762 | 11.265 | 17.130 | 9.907 |
6 | 13.746 | 13.825 | 11.347 | 18.016 | 11.004 |
Average | 16.814 | 18.350 | 12.832* | 20.714 | 10.199 |
Standard deviation | 7.199 | 4.686 | 3.036 | 11.963 | 3.179 |
* expression is irritated the stomach group relatively, significant difference (p<0.01) with Chinese liquor.
Mouse serum MDA content unit: nmol/ml is respectively organized in table 11 test in the time of the 20th day
Sample | The A group | The B group | The C group | The wine group | Normal group |
1 | 26.500 | 9.267 | 14.933 | 20.182 | 16.121 |
2 | 15.818 | 20.121 | 10.633 | 25.152 | 10.100 |
3 | 13.733 | 11.636 | 24.267 | 19.030 | 15.212 |
4 | 6.600 | 14.267 | 13.400 | 20.800 | 14.000 |
5 | 15.212 | 5.697 | 9.758 | 15.033 | 11.615 |
6 | 5.455 | 12.367 | 15.455 | 18.485 | 13.333 |
Average | 13.886** | 12.226** | 14.741** | 19.780 | 13.397 |
Standard deviation | 7.600 | 4.863 | 5.192 | 3.311 | 2.242 |
* represents to irritate the stomach group relatively with Chinese liquor, and difference is (p<0.01) extremely significantly.
White mice liver MDA content unit: nmol/ml is respectively organized in table 12 test in the time of the 30th day
Sample | The A group | The B group | The C group | The wine group | Normal group |
1 | 15.445 | 17.009 | 16.568 | 24.576 | 12.535 |
2 | 12.384 | 13.932 | 16.153 | 19.306 | 14.558 |
3 | 13.960 | 11.123 | 14.179 | 24.449 | 15.169 |
4 | 15.116 | 14.910 | 15.936 | 14.264 | 13.529 |
5 | 11.795 | 10.468 | 16.619 | 24.522 | 14.339 |
6 | 15.445 | 17.009 | 16.568 | 24.576 | 12.535 |
Average | 12.36** | 12.41** | 14.84* | 18.62 | 12.11 |
Standard deviation | 3.68 | 3.59 | 2.73 | 8.01 | 4.78 |
*, * * represents respectively and Chinese liquor is irritated the stomach group relatively, significant difference (p<0.01) and extremely remarkable (p<0.01).
Mouse serum MDA content unit: nmol/ml is respectively organized in table 13 test in the time of the 30th day
Sample | The A group | The B group | The C group | The wine group | Normal group |
1 | 12.739 | 9.554 | 11.688 | 13.248 | 7.006 |
2 | 9.777 | 14.904 | 6.306 | 18.599 | 9.968 |
3 | 17.707 | 11.688 | 7.643 | 13.212 | 6.975 |
4 | 7.739 | 10.096 | 19.713 | 18.885 | 17.197 |
5 | 19.299 | 6.911 | 10.541 | 16.369 | 14.713 |
6 | 7.580 | 15.414 | 12.484 | 16.210 | 9.873 |
Average | 12.47* | 11.43** | 11.40** | 16.09 | 10.96 |
Standard deviation | 5.05 | 3.28 | 4.72 | 2.47 | 4.16 |
*, * * represents respectively to irritate stomach group relatively and extremely significantly (p<0.01) with Chinese liquor.
2.3 middle drug solns is to the influence of alcoholic liver injury white mice liver and serum GSH (reduced glutathion) content
2.3.1 when testing the 10th day, each organizes the white mice liver and serum GSH content results sees Table 14,15.Compare with normal group; the liver of stomach group irritated by Chinese liquor and serum GSH content is minimum and significant difference (p<0.01); Chinese medicine A, B, C group liver and serum GSH content also obviously reduce; show that Chinese medicine A, B, C have certain protective role to the consumption of alcoholic liver injury white mice liver GSH, but DeGrain.
2.3.2 when testing the 20th day, each organizes the white mice liver and serum GSH content results sees Table 16,17.Though Chinese medicine B group liver and serum GSH content are starkly lower than normal group (p<0.05), be higher than Chinese medicine A, C group, show that Chinese medicine B is being better than Chinese medicine A and C aspect the consumption that reduces liver GSH.
2.3.3 when testing the 30th day, each organizes the white mice liver and serum GSH content results sees Table 18,19.The result shows; the liver and the serum GSH content of Chinese medicine A, B, C group are all close with normal group, and irritate the stomach group apparently higher than Chinese liquor, and the prolongation along with administration time is described; Chinese medicine A, B, C all can well reduce the consumption of liver GSH, can produce the better protect effect to liver.
White mice liver gsh content unit: mg/gprot is respectively organized in table 14 test in the time of the 10th day
Sample | The A group | The B group | The C group | The wine group | Normal group |
1 | 318.36 | 232.30 | 151.32 | 154.25 | 376.15 |
2 | 76.21 | 267.52 | 113.29 | 125.72 | 348.44 |
3 | 215.42 | 255.05 | 290.47 | 129.23 | 794.81 |
4 | 178.89 | 116.73 | 123.66 | 119.02 | 375.08 |
5 | 190.60 | 214.36 | 213.24 | 179.68 | 390.64 |
6 | 261.88 | 276.74 | 187.95 | 110.53 | 52.46 |
Average | 206.89 | 227.12 | 179.99 | 136.41 | 389.60 |
Standard deviation | 82.03 | 58.74 | 66.06 | 25.80 | 236.62 |
Mouse serum GSH content unit: mg/gprot is respectively organized in table 15 test in the time of the 10th day
Sample | The A group | The B group | The C group | The wine group | Normal group |
1 | 133.18 | 138.38 | 254.40 | 59.82 | 219.86 |
2 | 154.67 | 254.34 | ---- | 172.46 | 247.40 |
3 | 231.45 | 133.67 | 167.87 | ---- | 283.30 |
4 | 123.34 | ---- | 271.34 | 207.23 | 247.86 |
5 | 210.65 | 201.35 | 133.86 | 154.86 | 256.89 |
6 | ---- | 221.03 | 38.38 | 93.44 | 477.66 |
Average | 170.66 | 189.75 | 173.17 | 137.56 | 288.83 |
Standard deviation | 47.94 | 52.61 | 94.84 | 59.92 | 94.72 |
White mice liver gsh content unit: mg/gprot is respectively organized in table 16 test in the time of the 20th day
Sample | The A group | The B group | The C group | The wine group | Normal group |
1 | 132.46 | 213.99 | 284.21 | 234.65 | 148.31 |
2 | 122.63 | 211.85 | 108.49 | 301.52 | 242.49 |
3 | 72.85 | 508.82 | 152.23 | 130.47 | 546.41 |
4 | 91.34 | 151.39 | 206.59 | 177.59 | 492.15 |
5 | 353.92 | 558.37 | 534.87 | 207.80 | 610.32 |
6 | 226.33 | 404.15 | 280.88 | 363.67 | 494.98 |
Average | 166.59 | 341.43 | 261.21 | 235.95 | 422.44 |
Standard deviation | 106.03 | 172.14 | 150.99 | 84.78 | 183.48 |
Mouse serum GSH content unit: mg/gprot is respectively organized in table 17 test in the time of the 20th day
Sample | The A group | The B group | The C group | The wine group | Normal group |
1 | 311.86 | 220.05 | 234.14 | 66.38 | 224.91 |
2 | 54.89 | 190.42 | 327.40 | 25.32 | 160.79 |
3 | 120.47 | 116.58 | 71.41 | 162.27 | 165.16 |
4 | 24.29 | 374.52 | 153.50 | 82.33 | 335.66 |
5 | 196.25 | 184.59 | 50.19 | 13.27 | 397.84 |
6 | 73.84 | 71.41 | 52.02 | 30.70 | 213.25 |
Average | 130.26 | 192.93 | 148.11 | 63.38 | 249.60 |
Standard deviation | 107.26 | 104.29 | 113.38 | 55.09 | 96.26 |
White mice liver gsh content unit: mg/gprot is respectively organized in table 18 test in the time of the 30th day
Sample | The A group | The B group | The C group | The wine group | Normal group |
1 | 133.142 | 216.760 | 97.029 | 123.979 | 241.895 |
2 | 190.674 | 118.725 | 116.802 | 155.358 | 139.883 |
3 | 183.037 | 210.671 | 191.102 | 113.236 | 234.681 |
4 | 207.841 | 124.679 | 198.195 | 128.161 | 229.199 |
5 | 218.838 | 211.216 | 204.359 | 118.493 | 133.047 |
6 | 133.142 | 216.760 | 97.029 | 123.979 | 241.895 |
Average | 156.50 | 148.18 | 136.18 | 107.30 | 163.54 |
Standard deviation | 79.70 | 82.38 | 76.75 | 52.41 | 92.65 |
Mouse serum GSH content unit: mg/gprot is respectively organized in table 19 test in the time of the 30th day
Sample | The A group | The B group | The C group | The wine group | Normal group |
1 | 239.155 | 364.299 | 241.430 | 267.813 | 162.626 |
2 | 247.230 | 258.811 | 337.471 | 273.296 | 354.238 |
3 | 316.134 | 297.072 | 337.936 | 201.352 | 346.930 |
4 | 209.579 | 254.539 | 244.936 | 130.920 | 285.335 |
5 | 301.043 | 258.964 | 221.465 | 176.048 | 348.907 |
6 | 239.155 | 364.299 | 241.430 | 267.813 | 162.626 |
Average | 219.76 | 240.12 | 232.13 | 175.67 | 250.10 |
Standard deviation | 112.30 | 121.59 | 120.16 | 99.96 | 141.54 |
2.4 the result of histopathologic examination
In test the 15th, 30 day the time, each group is appointed and is got 2 white mice livers to carry out the check pathological section result as follows:
The 15th day:
As Figure 1A, Chinese medicine A group: visible a small amount of connective tissue between liver leaflet structure, lobule, do not see connective tissue proliferation, the streak distribution of hepatocyte; The hepatocyte karyon is clear, does not see that obvious degeneration changes and necrosis; Vascular structures such as central vein, hepatic sinusoid, interlobular veins and tremulous pulse are clear, do not see obviously hemorrhage, congestion etc.; Do not see obvious inflammatory cell infiltration and other inflammatory activity; Do not see cell parenchyma abnormality proliferation, do not see neoplastic lesion.
As Figure 1B, Chinese medicine B group: the liver organization structure is more clear, does not see connective tissue proliferation; Slight hepatic cell swelling is slight granular degeneration, does not see necrosis; Vascular structure is clear, does not see obviously hemorrhage, congestion etc.; Do not see obvious inflammatory cell infiltration; Do not see cell parenchyma abnormality proliferation, do not see neoplastic lesion.
As Fig. 1 C, Chinese medicine C group: swelling of liver cell, the obvious granular degeneration of hepatocyte, a few cell is as seen downright bad; Central vein, vascular structures such as hepatic sinusoid tremulous pulse are clear; Hematologys such as the visible congestion of portal area venule change; Do not see obvious inflammatory cell infiltration, do not see other inflammatory activity; Do not see cell parenchyma abnormality proliferation, do not see neoplastic lesion.
As Fig. 1 D, Chinese liquor is irritated the stomach group: liver organization is not obvious, hepatocyte serious swelling, the obvious granular degeneration of hepatocyte, blister degeneration, visible downright bad; Do not see that hematology such as obviously hemorrhage, congestion changes; Do not see obvious inflammatory cell infiltration; Do not see cell parenchyma abnormality proliferation, do not see neoplastic lesion.
As Fig. 1 E, normal group: do not see connective tissue proliferation, do not see that hematology such as obviously hemorrhage, congestion changes; Do not see obvious inflammatory cell infiltration; Do not see cell parenchyma abnormality proliferation, do not see neoplastic lesion.
The 30th day:
As Fig. 2 A, Chinese medicine A group: liver organization is leaflet structure, visible a small amount of connective tissue between lobule; The hepatocyte endochylema is abundant to be bright red and to dye, and karyon is clear, and visible obviously kernel does not see that obvious degeneration changes and downright bad; Do not see that hematology such as obviously hemorrhage, congestion changes; Do not see obvious inflammatory cell infiltration, do not see other inflammatory activity; Do not see cell parenchyma abnormality proliferation, do not see neoplastic lesion.
As Fig. 2 B, Chinese medicine B group: visible a small amount of connective tissue between the liver lobule, do not see connective tissue proliferation; Slight hepatic cell swelling is slight granular degeneration, does not see necrosis; Do not see obvious inflammatory cell infiltration, do not see other inflammatory activity; Do not see cell parenchyma abnormality proliferation, do not see neoplastic lesion.
As Fig. 2 C, Chinese medicine C group: visible a small amount of connective tissue between the liver lobule, do not see connective tissue proliferation; Slight hepatic cell granular degeneration and vacuolar degeneration do not see that hematology such as obviously hemorrhage, congestion changes; Do not see obvious inflammatory cell infiltration, do not see other inflammatory activity; Do not see cell parenchyma abnormality proliferation, do not see neoplastic lesion.
As Fig. 2 D, Chinese liquor is irritated the stomach group: liver organization is irregular leaflet structure, and visible a small amount of connective tissue is not seen connective tissue proliferation between lobule; The swelling of hepatocyte severe, the obvious granular degeneration of hepatocyte, a few cell is as seen downright bad.
As Fig. 2 E, normal group: the streak distribution of hepatocyte, the hepatocyte endochylema is abundant to be bright red and to dye, and karyon is clear, and visible obviously kernel does not see that obvious degeneration changes and downright bad; Do not see obviously hemorrhage, congestion etc., do not see obvious inflammatory cell infiltration, do not see other inflammatory activity,
3 conclusions
3.1 AST and ALT are two kinds of important enzymes of reflection liver function, the high more expression liver function damage of their content rising is serious more.This is tested in preceding 20 days, and the hepatoprotective effect of Chinese medicine B obviously is better than Chinese medicine A and C.Along with the prolongation of administration time, Chinese medicine B is close with the C effect, and Chinese medicine A effect is relatively poor.
Cause the snperoxiaized primary product of membrane lipid 3.2 MDA is a free radical, its content rising expression membrane lipid peroxidating is impaired serious.When being index with liver MDA content in this test, Chinese medicine C group will obviously be better than Chinese medicine A, B group to the protective effect of liver radical damage; But when Content of MDA was index, along with the prolongation of administration time, Chinese medicine A, B, C group all had good reduction liver effect of free radicals damage.
3.3 GSH (reduced glutathion) is a kind of good scavenger to external harmful substance in the body, when harmful substance increases when causing that damage is serious, GSH will be consumed and increase even exhausted, show as GSH content and extremely reduce.When being index with GSH content in this test, Chinese medicine B is better than Chinese medicine A and Chinese medicine C to the protective effect of liver, the prolongation in the test later stage along with administration time, and Chinese medicine A, B, C all can well reduce the consumption of liver GSH, promptly all can produce protective effect to liver.
3.4 this test overall merit shows: Chinese liquor is early stage gavaging continuously, and the hepatoprotective effect of Cordyceps polysaccharide+krestin+Hericium Erinaceus Polysaccharide mixed solution is better than krestin solution and krestin+Hericium Erinaceus Polysaccharide solution.Along with the prolongation of administration time, the three all has good hepatoprotective effect.
Claims (7)
1. a Medicament for Alcoholism is characterized in that its primary raw material and parts by weight thereof are: krestin extract 65-80 part.
2. Medicament for Alcoholism as claimed in claim 1 is characterized in that described Medicament for Alcoholism also comprises following component: Hericium Erinaceus Polysaccharide extract 10-20 part.
3. Medicament for Alcoholism as claimed in claim 2 is characterized in that described Medicament for Alcoholism also comprises following component: Cordyceps polysaccharide extract 10-20 part.
4. Medicament for Alcoholism as claimed in claim 3, it is characterized in that, after krestin extract, Hericium Erinaceus Polysaccharide extract, three kinds of raw materials of Cordyceps polysaccharide extract mix, the ratio of weight and number of active ingredient is in the mixture, krestin 20-35 part, Cordyceps polysaccharide 5-18 part, Hericium Erinaceus Polysaccharide 5-15 part.
5. Medicament for Alcoholism as claimed in claim 1, it is characterized in that described Medicament for Alcoholism also comprises Fructus Lycii extract or/and Semen Cuscutae extract Huo/with the peppery element of Ginger.
6. Medicament for Alcoholism as claimed in claim 5 is characterized in that the parts by weight of Fructus Lycii extract, the peppery element of Semen Cuscutae extract, Ginger are: Fructus Lycii extract 3-8 part, Semen Cuscutae extract 3-8 part, Fructus Lycii extract 3-8 part.
7. as claim 1 or 4 described Medicament for Alcoholism, it is characterized in that with pharmaceutically acceptable pharmaceutic adjuvant together, this Medicament for Alcoholism is made capsule, tablet, granule or oral liquid.
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CN103271404A (en) * | 2013-06-18 | 2013-09-04 | 吉林省绳氏堂药业有限公司 | Wine decanting, stomach and liver protecting and hangover-preventing beverage and preparation method thereof |
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CN105395702A (en) * | 2015-12-09 | 2016-03-16 | 江苏神华药业有限公司 | Composition with hangover alleviating, liver protecting and anti-fatigue efficacy and application thereof |
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CN103271404A (en) * | 2013-06-18 | 2013-09-04 | 吉林省绳氏堂药业有限公司 | Wine decanting, stomach and liver protecting and hangover-preventing beverage and preparation method thereof |
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CN105395702A (en) * | 2015-12-09 | 2016-03-16 | 江苏神华药业有限公司 | Composition with hangover alleviating, liver protecting and anti-fatigue efficacy and application thereof |
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