CN101151569B - Methods for reducing corneal staining in contact lens wearers - Google Patents
Methods for reducing corneal staining in contact lens wearers Download PDFInfo
- Publication number
- CN101151569B CN101151569B CN2004800443875A CN200480044387A CN101151569B CN 101151569 B CN101151569 B CN 101151569B CN 2004800443875 A CN2004800443875 A CN 2004800443875A CN 200480044387 A CN200480044387 A CN 200480044387A CN 101151569 B CN101151569 B CN 101151569B
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- Prior art keywords
- lens
- outer regions
- rear surface
- zone
- cornea
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- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
- G02C7/048—Means for stabilising the orientation of lenses in the eye
Abstract
The present invention provides a lens with reduced peak pressure at the low side of the eye and face of the lens wearer. The present invention provides a lens designing which can reduce or eliminate the mechanical friction of the cornea in the lens which is made from high modulus material.
Description
Technical field
The present invention relates to contact lens.Particularly, the invention provides a kind of cornea of lens wearer that makes and pollute the lens of the generation minimizing of (corneal staining).
Background technology
The employing contact lens is proofreaied and correct visual sensitivity or is well-known for cosmetic purpose.Soft-contact lens is known, and usually, the making material of this lens includes but not limited to hydrogel and siloxanes aquogel.
In the eyes of the normal lens wearer of using, the part of soft-contact lens covers on wearer's cornea.By cornea, pollute or instil and diagnose the keratocyte damage of observing after dyestuff can betide the soft-contact lens wearer at anterior corneal surface.It should be noted that especially lens mechanical friction on cornea causes polluting.This pollution is considered to a kind of indication of cornea tissue division.Lathe cutting lens are being worn in this damage, with Young modulus, be 40 psi(pounds/square inch) or the lens made of larger material, lens with the bending of single rear surface, and center thickness, the perimeter thicknesses section, or tranverse sectional thickness or both thickness all surpass in the wearer of lens of 0.1 mm and all observe.
In addition, keratocyte damage is observed in the wearer who wears the lens that front surface or rear surface have geometry in particular.The geometric configuration that goes wrong especially is that those cause occurring that in the middle outer regions of lens surface is discontinuous in the connection between zone on lens front surface or rear surface.Purpose of the present invention, because middle outer regions is the non-optical zone outside the optical zone of lens geometric center and rims of the lens, should cover on cornea in zone when lens are worn on eyes.Typically, this zone has the approximately radius of 3.5 to 6.5 mm from the lens geometric center.Finally, having thickness distribution is not that the lens in the zone of constant can cause the keratocyte damage.
The cornea pollution that causes due to mechanical friction usually occurs in the cornea upper area most, or the cornea zone of pupil top, and the Trans-corneal inferior zone, or the zone of pupil below.Therefore, the cellular damage most probable appears at the cornea zone of upper eyelid or palpebra inferior below.The material and design variation of the probability of cornea pollution with lens occurs, but can reach 50% of lens wearer.Therefore, there is a kind of demand of the Lens Design that makes cornea pollute the incidence reduction or disappear.
The accompanying drawing explanation
Fig. 1 is the lens cut-open view that the present invention amplifies.
Fig. 2 is the plan view that the lens front surface of Fig. 1 amplifies.
Summary of the invention and preferred embodiment
The invention provides a kind of cornea for reducing lens wearer and pollute the method for probability and the lens that adopt the method to make.Can think that the cornea pollution that mechanical friction causes is the most often produced by the surge pressure on cornea (peak pressure), the meaning is being born the larger pressure of this lens area with respect to the close region cornea zone of cornea exactly.Modal, these surge pressure zones appear at the lens wearer eyelid below.Lens thickness distributes, or tranverse sectional thickness, material modulus, and one or more in the connection of lens surface areas have caused described surge pressure.
In one embodiment, the invention provides a kind of contact lens and comprise, substantially comprise, or comprise that at least one has the surface that surge pressure reduces to design.
A kind of Lens Design of the present invention provides an equal thickness vertical section.Wherein the meaning of " equal thickness vertical section " is between lens front surface and rear surface and along the rear surface orthogonal directions, measures any meridian direction of radial thickness in 45 degree of the vertical meridian direction (90-270 degree axle) along lens of outer regions in the middle of lens and be uniformly distributed.It is constant that the equal thickness vertical section makes the sectional thickness of the middle outer regions of lens in the zone around the vertical meridian direction of lens.
Fig. 1 shows the lens 10 that embody this design.Middle outer regions 11 is presented at top (top) part and below (end) part of lens, in this part, has used the equal thickness vertical section.Fig. 2 shows the plan view that shows open and flat regional 11 the lens that make progress.
The equal thickness vertical section can form desired section by biasing upper surface periphery and lower surface periphery.This section can obtain by any method for designing, includes but not limited to, in conjunction with from axle inclination curved surface or use a plurality of perimeter region.In addition, United States Patent (USP) 6,595,640 method for designing also can be used, and the content of this patent is all quoted at this.
In another interchangeable embodiment of the present invention, in the smoothed processing in coupling part between zones of different on one or two surface of lens, discontinuous on Shang De inclined-plane, rear surface to eliminate.More particularly, the first order derivative in the coupling part between sweep on rear surface is consistent in this embodiment, that is, the bending slope of coupling part is consistent.Any method that is used for obtaining the smooth connection part includes but not limited to apply conventional mathematical technique and merges two continuous zones.
Lens of the present invention preferably stablize to keep their orientation towards eyeball rotatably.Suitable spin stabilization comprises that prism is stable, the balance of stable, the prism eccentric with respect to rear surface by the front surface that makes lens of described prism, add the thick lens lower limb, lower on the face support of lens, spend the lens surfaces formation concave surface of meridian directions or convex surface or brachymemma rims of the lens and realize leaving 90.Replacedly, or stable in conjunction with prism, and lens can be dynamic stabilities.Dynamic stability comprises the thickness that reduces lens outer surface on two symmetrical zones, is increased in the thickness in two zones on horizontal middle spindle, and attenuate, or top region and the bottom zone of layer stripping lens.Typically, stable zone is positioned at the lens periphery, namely around the lens non-optic portion of optical zone, but does not comprise rims of the lens and with respect to the part of geometric center lens ragged edge.
The present invention can be used for designing single vision, multifocal point and toric lens.In addition, the present invention can be used for designing the lens of making of any suitable contact lens material.However, the improvement of maximum of the present invention is by in the lens periphery, using the zone of different-thickness to make the lens spin stabilization and/or be approximately 40 psi(pounds/square inch with yang type modulus), be preferably approximately 60 psi(pounds/square inch), or the material of higher high-modulus is made lens.
Exemplary high-modulus lens material includes, but are not limited to hydrogel, and hydrogel includes, but not limited to etafilcon A.Preferably, the lens of the present invention for being made by siloxanes aquogel, siloxane is a kind of like this material: comprise one or more component and one or more hydrophilic component, for example galyfilcon that contain siloxane.
One or more component and one or more hydrophilic components that contain siloxane can be that the known part of siloxanes aquogel is made in any use in the prior art.Term " component that contains siloxane " and " hydrophilic component " are not mutually exclusive, because the component that contains siloxane can have a little water wettability and hydrophilic component can comprise some siloxane.
Contain the component of siloxane at monomer, macromonomer, or in prepolymer, include at least one [Si-O-Si-] group.Preferably, the O that is present in Si in the component that contains siloxane and connection surpasses 20 % by weight of total molecule weight of the component that contains siloxane on content, or more preferably surpasses 30 % by weight.The useful component that contains siloxane preferably comprises polymerisable functional group, acrylate for example, methacrylate, acrylamide, Methacrylamide, N-vinyl lactam, N-ethernamine, and styryl functional group.The example of the useful component that contains siloxane can be 3,808,178 at U.S. Patent number in the present invention; 4,120,570; 4,136,250; 4,153,641; 4,740,533; 5,034,461 and 5,070,215 and patent EP080539 in obtain.All above-mentioned patents of here quoting are incorporated herein by reference in this integral body.
The further example of the monomer that contains siloxane that is suitable for is that polysiloxane group alkyl (methyl) acrylic monomers comprises, but be not restricted to, methacryloxypropyl three (trimethylsiloxy) silane, pentamethyl dimethylamino silane oxygen ylmethyl methacrylate, and methyl two (trimethylsiloxy) methacryloxy methyl-monosilane.
The preferred class of component that contains siloxane is poly (organosiloxane) prepolymer, α for example, ω-dimethyl allene acyloxy propyl group dimethyl silicone polymer.Another preferred example is mPDMS(monomethyl acryloxy propyl group end list-normal-butyl end dimethyl silicone polymer).Useful another kind of vinyl carbonic ester or the vinyl carbamate monomer that comprises silicone-containing of component that contains siloxane, comprise, but be not restricted to, 1,3-bis-[4-(ethyleneoxy carboxyl) butyl-1-yl] tetramethyl-siloxane 3-(ethylene oxy carbonyl sulfo-) propyl group-[three (trimethylsiloxy silane]; 3-[tri--(trimethylsiloxy) silicyl] propyl group allyl amino formic ether; 3-[tri-(trimethylsiloxy) wilyl] propyl vinyl carbamate; Trimethyl silyl ethyl vinyl carbonic ester; With trimethyl silyl methyl ethylene carbonic ester.
Hydrophilic component comprises that those can provide the part with respect to the water cut of finished lens about at least 20% preferred about at least 25% when with rest activity, partly combining.The hydrophilic component that is suitable for weight with respect to all active parts on content can account for about 10 to about 60 % by weight.About 15 arrive about 40 % by weight to about 50 % by weight or preferred percentage by weight about 20.The hydrophilic monomer that can be used for preparing polymkeric substance of the present invention has at least one polymerisable double bond and at least one hydrophilic functional groups.The example of polymerizable double bond comprises acrylic; methacrylic acid group, acrylamido, methacryl amido; the fumaryl base; maleoyl, styryl, isopropenyl phenyl; O-vinyl carbonic ester; the O-vinyl carbamate, allyl, the two keys of O-vinyl acetyl group and N-vinyl lactam and N-vinyl acyl ammonia.Described hydrophilic monomer itself can be used as crosslinking chemical." acrylic acid-type " or " containing acrylic acid " monomer is those monomers that comprise acryloyl group (CR ˋ H=CRCOX).
Wherein R is H or methyl, and R ˋ is H, alkyl or carbonyl, with X be O or N, this is the known polymerization that is easy to, for example N,N-DMAA (DMA), the 2-hydroxy ethyl methacrylate, glyceral methacrylate, 2-hydroxyethyl methacrylamide, polyethylene glycol monomethacrylate, methacrylic acid, acrylic acid and composition thereof.
The hydrophilic vinyl-containing monomers that can be incorporated to hydrogel of the present invention comprises for example N-vinyl lactam (for example NVP (NVP)) of following monomer, N-vinyl-N-methylacetamide, N-vinyl-N-ethyl acetamide, N-vinyl-N-ethyl-formamide, the N-vinyl formamide, N-2-hydroxyethyl vinyl carbamate, N-Suo Ji – β-alanine N-vinyl esters, NVP is preferred.
Other hydrophilic monomer that can apply in the present invention comprises the polyoxyethylene polyols that substitutes one or more terminal hydroxyls with the functional group that comprises polymerizable double bond.Example comprises the polyglycol that substitutes one or more terminal hydroxyls with the functional group of containing polymerizable double bond.Example comprise polyglycol and one or more moles of terminal groups equivalents react to generate have one or more by coupling part for example carbamate or ester group make one or more end polymerizable olefinic group bondings to the polyglycol on polyglycol, this end-capping group comprises for example methacrylic acid isocyanate group ethyl ester (" IEM "), methacrylic anhydride, methacrylic chloride, the vinyl benzene formyl chloride, etc.
Further example is at United States Patent (USP) 5,070, disclosed hydrophilic vinylic carbonic ester or vinyl carbamate monomer and at United States Patent (USP) 4,190 in 215, disclosed Qin Shui azolactone monomer in 277.Other hydrophilic monomer that is suitable for it will be apparent to those skilled in the art that.The preferred hydrophilic monomer of introducing polymkeric substance of the present invention comprises for example N,N-DMAA (DMA), acrylic acid 2-hydroxyl ethyl ester, glyceral methacrylate, the 2-hydroxyethyl methacrylamide, NVP (NVP), and polyethylene glycol monomethacrylate.Most preferred hydrophilic monomer comprises DMA, NVP and its potpourri.
Solidifying of lens material can be undertaken by any traditional method.For example, material can use the mould deposition and pass through heat, radiation, and chemistry, electromagnetic radiation is curing to be waited and combination.Preferably, with ultraviolet light or with the full spectrum of visible light, carry out molding.More specifically, the accurate condition of suitable cured lens material depends on the material of selection and the lens of the moulding of wanting.United States Patent (USP) 4,495,313,4,680,336,4,889,664,5,039,459 and 5,540,410 disclose the technique that is suitable for, and here integral body is incorporated herein by reference.
Contact lens of the present invention can be made by any method easily.A described method is carried out the analogue formation embolus with lathe.Mold insert is used for again forming mould conversely.Therefore, a kind of suitable lens material is placed between mould and by compression and cured resin, forms lens of the present invention subsequently.Those of ordinary skill in the art can know any other can be used for making the known method of lens of the present invention.
Claims (8)
1. contact lens, comprise that at least one has the surface that surge pressure reduces to design, these lens comprise at least one equal thickness vertical section in outer regions in the middle of described lens, the meaning of its intermediate gauge vertical section is between lens front surface and rear surface and along the rear surface orthogonal directions, measures any meridian direction of radial thickness in 45 degree along the vertical meridian direction of lens of outer regions in the middle of lens and be uniformly distributed
Described contact lens stablizes to keep their orientation towards eyeball rotatably, described spin stabilization for, prism balance eccentric with respect to rear surface by the front surface that makes lens, add the thick lens lower limb, support of lens, the prism realized at the lens surfaces formation concave surface that leaves 90 degree meridian directions or convex surface or brachymemma rims of the lens are stablized on the face at lower
In the middle of wherein said, outer regions refers to the non-optical zone outside the optical zone between lens geometric center and rims of the lens, and this zone covers on cornea when lens are worn on eyes.
2. lens as claimed in claim 1, further comprise following surface: this surface has at least two different curves of slope that have coupling part therebetween, at connecting portion office slope of a curve, is wherein consistent.
3. lens as claimed in claim 1, the Young modulus of wherein said lens is 40 psi or larger.
4. lens as claimed in claim 2, the Young modulus of wherein said lens is 40 psi or larger.
5. as the lens of any one in claim 1-4, wherein spin stabilization comprises that the lens thickness of comparing on the symmetrical zone of lens periphery two with the remaining area of lens periphery reduces.
6. lens as claimed in claim 5, wherein said lens are toric lenses.
7. method that designs contact lens, comprise and provide at least one to have the step on the surface that surge pressure reduces, further comprise the step that at least one equal thickness vertical section in outer regions in the middle of described lens is provided, the meaning of its intermediate gauge vertical section is between lens front surface and rear surface and along the rear surface orthogonal directions, measures any meridian direction of radial thickness in 45 degree along the vertical meridian direction of lens of outer regions in the middle of lens and be uniformly distributed
Further comprise the step that spin stabilization is provided, described spin stabilization refers to that described contact lens stablizes to keep their orientation towards eyeball rotatably, described spin stabilization for, prism balance eccentric with respect to rear surface by the front surface that makes lens, add the thick lens lower limb, support of lens, the prism realized at the lens surfaces formation concave surface that leaves 90 degree meridian directions or convex surface or brachymemma rims of the lens are stablized on the face at lower
In the middle of wherein said, outer regions refers to the non-optical zone outside the optical zone between lens geometric center and rims of the lens, and this zone covers on cornea when lens are worn on eyes.
8. method as claimed in claim 7, further comprise the step on the surface that provides following: this surface has at least two different curves of slope that have coupling part therebetween, at connecting portion office slope of a curve, is wherein consistent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310484548.3A CN103543539B (en) | 2004-11-12 | 2004-11-12 | A kind of method that cornea reducing contact lens wearer pollutes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2004/037836 WO2006054970A1 (en) | 2004-11-12 | 2004-11-12 | Methods for reducing corneal staining in contact lens wearers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310484548.3A Division CN103543539B (en) | 2004-11-12 | 2004-11-12 | A kind of method that cornea reducing contact lens wearer pollutes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101151569A CN101151569A (en) | 2008-03-26 |
| CN101151569B true CN101151569B (en) | 2013-11-20 |
Family
ID=34959619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2004800443875A Active CN101151569B (en) | 2004-11-12 | 2004-11-12 | Methods for reducing corneal staining in contact lens wearers |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1817627A1 (en) |
| JP (1) | JP4855412B2 (en) |
| CN (1) | CN101151569B (en) |
| AU (1) | AU2004324989A1 (en) |
| BR (1) | BRPI0419181B1 (en) |
| CA (1) | CA2587322C (en) |
| WO (1) | WO2006054970A1 (en) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5020898A (en) * | 1990-01-29 | 1991-06-04 | Schering Corporation | Contact lens for correction of astigmatism |
| US5650838A (en) * | 1995-05-04 | 1997-07-22 | Johnson & Johnson Vision Products, Inc. | Programmable smooth junctions on lenses |
| EP0889348A1 (en) * | 1997-07-03 | 1999-01-07 | Gérard Muller | Process for manufacturing a contact lens with axial correction having at least one stabilising boss and contact lens of this type |
| US6467903B1 (en) * | 2000-03-31 | 2002-10-22 | Ocular Sciences, Inc. | Contact lens having a uniform horizontal thickness profile |
| JP5051808B2 (en) * | 2000-12-11 | 2012-10-17 | 東レ株式会社 | Plastic molded product and contact lens comprising the same |
| JP4500551B2 (en) * | 2002-04-12 | 2010-07-14 | 株式会社メニコン | Contact lens and method of manufacturing contact lens |
| AU2003902102A0 (en) * | 2003-05-02 | 2003-05-22 | The Institute For Eye Research | Contact lens |
-
2004
- 2004-11-12 EP EP04810854A patent/EP1817627A1/en not_active Ceased
- 2004-11-12 JP JP2007541154A patent/JP4855412B2/en active Active
- 2004-11-12 CA CA2587322A patent/CA2587322C/en active Active
- 2004-11-12 AU AU2004324989A patent/AU2004324989A1/en not_active Abandoned
- 2004-11-12 WO PCT/US2004/037836 patent/WO2006054970A1/en active Application Filing
- 2004-11-12 CN CN2004800443875A patent/CN101151569B/en active Active
- 2004-11-12 BR BRPI0419181A patent/BRPI0419181B1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0419181A (en) | 2007-12-18 |
| EP1817627A1 (en) | 2007-08-15 |
| AU2004324989A1 (en) | 2006-05-26 |
| JP4855412B2 (en) | 2012-01-18 |
| CA2587322C (en) | 2014-01-14 |
| CA2587322A1 (en) | 2006-05-26 |
| WO2006054970A1 (en) | 2006-05-26 |
| CN101151569A (en) | 2008-03-26 |
| JP2008520002A (en) | 2008-06-12 |
| BRPI0419181B1 (en) | 2017-03-28 |
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