CN103543539A - Method for reducing cornea pollution of contact lens wearer - Google Patents
Method for reducing cornea pollution of contact lens wearer Download PDFInfo
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- CN103543539A CN103543539A CN201310484548.3A CN201310484548A CN103543539A CN 103543539 A CN103543539 A CN 103543539A CN 201310484548 A CN201310484548 A CN 201310484548A CN 103543539 A CN103543539 A CN 103543539A
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Abstract
The invention provides a lens for reducing peak pressure under an eyelid of a lens wearer. The invention provides a lens design. Through the lens design, the mechanical friction of cornea in the lens which is even made of high modulus materials can be reduced or eliminated.
Description
The application is that application number is 200480044387.5 (international application no is PCT/US2004/037836), the applying date to be dividing an application of on November 12nd, 2004, the denomination of invention application for a patent for invention that is " a kind of method that cornea that reduces contact lens wearer pollutes ".
Technical field
The present invention relates to contact lens.Particularly, the invention provides a kind of cornea of lens wearer that makes and pollute the lens of the generation minimizing of (corneal staining).
Background technology
Employing contact lens is proofreaied and correct visual sensitivity or is well-known for cosmetic purpose.Soft-contact lens is known, and conventionally, the making material of this lens includes but not limited to hydrogel and siloxanes aquogel.
In the eyes of the normal lens wearer of using, a part for soft-contact lens covers on wearer's cornea.By cornea, pollute or instil and diagnose the keratocyte damage of observing after dyestuff can betide soft-contact lens wearer at anterior corneal surface.It should be noted that especially lens mechanical friction on cornea causes polluting.This pollution is considered to a kind of indication of cornea tissue division.Lathe cutting lens are being worn in this damage, with Young modulus be 40psi (pound/square inch) or the lens made of larger material, the lens with the bending of single rear surface, and center thickness, perimeter thicknesses section, or tranverse sectional thickness or both thickness all surpass in the wearer of lens of 0.1mm and all observe.
In addition, keratocyte damage is observed in the wearer who wears the lens that front surface or rear surface have geometry in particular.The geometric configuration going wrong is especially that those connections between region on lens front surface or rear surface cause occurring that in the middle outer regions of lens surface is discontinuous.Object of the present invention, because middle outer regions is the non-optical region outside the Optical Region of lens geometric center and rims of the lens, when lens are worn on eyes, this region is covering on cornea.Typically, this region has approximately 3.5 radiuses to 6.5mm from lens geometric center.Finally, having thickness distribution is not that the lens in the region of constant can cause keratocyte damage.
The cornea pollution causing due to mechanical friction usually occurs in cornea upper area most, or the cornea region of pupil top, and Trans-corneal inferior region, or the region of pupil below.Therefore, cellular damage most probable appears at the cornea region of upper eyelid or palpebra inferior below.There is the probability of cornea pollution with the material and design variation of lens, but can reach 50% of lens wearer.Therefore, there is a kind of demand of the Lens Design that makes cornea pollute incidence reduction or disappear.
Accompanying drawing explanation
Fig. 1 is the lens cut-open view that the present invention amplifies.
Fig. 2 is the plan view that the lens front surface of Fig. 1 amplifies.
Summary of the invention and preferred embodiment
The invention provides a kind of cornea for reducing lens wearer and pollute the method for probability and the lens that adopt the method to make.Can think that the cornea pollution that mechanical friction causes is the most often produced by the surge pressure on cornea (peak pressure), the meaning is being born the larger pressure of this lens area with respect to the close region cornea region of cornea exactly.Modal, these surge pressure regions appear at lens wearer eyelid below.Lens thickness distributes, or tranverse sectional thickness, material modulus, and the surge pressure described in one or more having caused in the connection of lens surface areas.
In one embodiment, the invention provides a kind of contact lens and comprise, substantially comprise, or comprise that at least one has the surface that surge pressure reduces design.
A kind of Lens Design of the present invention provides an equal thickness vertical section.Wherein the meaning of " equal thickness vertical section " is between lens front surface and rear surface and any meridian direction of the radial thickness of measuring outer regions in the middle of lens along rear surface orthogonal directions in 45 degree of the vertical meridian direction (90-270 degree axle) along lens is uniformly distributed.It is constant that equal thickness vertical section makes the sectional thickness of the middle outer regions of lens in the vertical meridian direction of lens region around.
Fig. 1 shows the lens 10 that embody this design.Middle outer regions 11 is presented at top (top) part and below (end) part of lens, has used equal thickness vertical section in this part.Fig. 2 shows the plan view of the lens that show the open and flat region 11 that makes progress.
Equal thickness vertical section can form desired section by biasing upper surface periphery and lower surface periphery.This section can obtain by any method for designing, includes but not limited to, in conjunction with from axle inclination curved surface or use a plurality of perimeter region.In addition, United States Patent (USP) 6,595,640 method for designing also can be used, and the content of this patent is all quoted at this.
In another interchangeable embodiment of the present invention, the smoothed processing in coupling part on one or two surface of lens between zones of different, discontinuous with the inclined-plane of eliminating on rear surface.More particularly, on rear surface, the first order derivative of the coupling part between sweep is consistent in this embodiment, that is, the bending slope of coupling part is consistent.Any method that is used for obtaining smooth connection part includes but not limited to apply conventional mathematical technique and merges two continuous regions.
Lens of the present invention preferably stablize to keep their orientation towards eyeball rotatably.Suitable spin stabilization comprises that prism is stable, prism is stable to be comprised, but be not limited to, make the front surface of lens eccentric with respect to rear surface, the balance of prism, adds thick prism lower limb, lower support of lens on the face, at the lens surface that leaves 90 degree meridian directions, form concave surface or convex surface, and brachymemma rims of the lens.Alternatively, or stable in conjunction with prism, and lens can be dynamic stabilities.Dynamic stability comprises the thickness that reduces lens outer surface on two symmetrical regions, is increased in the thickness in two regions on horizontal middle spindle, and attenuate, or top region and the bottom zone of layer stripping lens.Typically, stable region is positioned at lens periphery, around the lens non-optic portion of Optical Region, but does not comprise rims of the lens and with respect to the part of geometric center lens ragged edge.
The present invention can be used for designing single vision, multifocal point and toric lens.In addition, the present invention can be used for the lens that design is made of any applicable contact lens material.However, the improvement of maximum of the present invention be by lens periphery, use the region of different-thickness make lens spin stabilization and/or with yang type modulus be approximately 40psi (pound/square inch), be preferably approximately 60psi (pound/square inch), or the material of higher high-modulus is made lens.
Exemplary high-modulus lens material includes, but are not limited to hydrogel, and hydrogel includes, but not limited to etafilconA.Preferably, the lens of the present invention for being made by siloxanes aquogel, siloxane is a kind of like this material: comprise one or more components that contain siloxane and one or more hydrophilic component, for example galyfilcon.
One or more components that contain siloxane and one or more hydrophilic component can be that the known part of siloxanes aquogel is made in any use in the prior art.Term " component that contains siloxane " and " hydrophilic component " are not mutually exclusive, because the component that contains siloxane can have water wettability and hydrophilic component a little can comprise a little siloxane.
The component that contains siloxane is at monomer, macromonomer, or in prepolymer, include at least one [Si-O-Si-] group.Preferably, the O that is present in Si in the component that contains siloxane and connection surpasses 20 % by weight of total molecular wt of the component that contains siloxane on content, or more preferably surpasses 30 % by weight.The useful component that contains siloxane preferably comprises polymerisable functional group, acrylate for example, methacrylate, acrylamide, Methacrylamide, N-vinyl lactam, N-ethernamine ，He styryl functional group.The example of the useful component that contains siloxane can be 3,808,178 at U.S. Patent number in the present invention; 4,120,570; 4,136,250; 4,153,641; 4,740,533; 5,034,461 and 5,070,215 and patent EP080539 in obtain.All above-mentioned patents of here quoting are incorporated herein by reference in this integral body.
The further example of the monomer that contains siloxane being applicable to is that polysiloxane group alkyl (methyl) acrylic monomers comprises, but be not restricted to, methacryloxypropyl three (trimethylsiloxy) silane, pentamethyl dimethylamino silane oxygen ylmethyl methacrylate, and methyl two (trimethylsiloxy) methacryloxy methyl-monosilane.
The preferred class of component that contains siloxane is poly (organosiloxane) prepolymer, α for example, ω-dimethyl allene acyloxy propyl group dimethyl silicone polymer.Another preferred example is mPDMS (monomethyl acryloxy propyl group end list-normal-butyl end dimethyl silicone polymer).Useful another kind of vinyl carbonic ester or the vinyl carbamate monomer that comprises silicone-containing of component that contains siloxane, comprise, but be not restricted to, 1,3-bis-[4-(ethyleneoxy carboxyl) butyl-1-yl] tetramethyl-siloxane 3-(ethylene oxy carbonyl sulfo-) propyl group-[three (trimethylsiloxy silane]; 3-[tri--(trimethylsiloxy) silicyl] propyl group allyl amino formic ether; 3-[tri-(trimethylsiloxy) wilyl] propyl vinyl carbamate; Trimethyl silyl ethyl vinyl carbonic ester; With trimethyl silyl methyl ethylene carbonic ester.
Hydrophilic component comprises that those can provide the part with respect to the water cut of finished lens at least about 20% preferred at least about 25% when partly combining with rest activity.Applicable hydrophilic component weight with respect to all active parts on content can account for about 10 to about 60 % by weight.About 15 arrive about 40 % by weight to about 50 % by weight or preferred percentage by weight about 20.The hydrophilic monomer that can be used for preparing polymkeric substance of the present invention has at least one polymerisable double bond and at least one hydrophilic functional groups.The example of polymerizable double bond comprises acrylic; methacrylic acid group, acrylamido, methacryl amido; fumaryl base; maleoyl, styryl, isopropenyl phenyl; O-vinyl carbonic ester; O-vinyl carbamate, allyl, the two keys of O-vinyl acetyl group and N-vinyl lactam and N-vinyl acyl ammonia.Described hydrophilic monomer itself can be used as crosslinking chemical." acrylic acid-type " or " containing acrylic acid " monomer is those monomers that comprise acryloyl group (CR`H=CRCOX).
Wherein R is H or methyl, and R` is H, alkyl or carbonyl, with X be O or N, this is the known polymerization that is easy to, for example N,N-DMAA (DMA), 2-hydroxy ethyl methacrylate, glyceral methacrylate, 2-hydroxyethyl methacrylamide, polyethylene glycol monomethacrylate, methacrylic acid, acrylic acid and composition thereof.
The hydrophilic vinyl-containing monomers that can be incorporated to hydrogel of the present invention comprises for example N-vinyl lactam (for example NVP (NVP)) of following monomer, N-vinyl-N-methylacetamide, N-vinyl-N-ethyl acetamide, N-vinyl-N-ethyl-formamide, N-vinyl formamide, N-2-hydroxyethyl vinyl carbamate, N-carboxyl-β-alanine N-vinyl esters, NVP is preferred.
Other hydrophilic monomer that can apply in the present invention comprises the polyoxyethylene polyols that substitutes one or more terminal hydroxyls with the functional group that comprises polymerizable double bond.Example comprises the polyglycol that substitutes one or more terminal hydroxyls with the functional group of containing polymerizable double bond.Example comprise polyglycol and one or more moles of terminal groups equivalents react to generate have one or more by coupling part for example carbamate or ester group make one or more end polymerizable olefinic group bondings to the polyglycol on polyglycol, this end-capping group comprises for example methacrylic acid isocyanate group ethyl ester (" IEM "), methacrylic anhydride, methacrylic chloride, vinyl benzene formyl chloride, etc.
Further example is at United States Patent (USP) 5,070, and disclosed hydrophilic vinylic carbonic ester or vinyl carbamate monomer and at United States Patent (USP) 4,190 in 215 are disclosed hydrophilic in 277
oxazolone monomer.Other applicable hydrophilic monomer it will be apparent to those skilled in the art that.The preferred hydrophilic monomer of introducing polymkeric substance of the present invention comprises for example N, N-DMAA (DMA), acrylic acid 2-hydroxyl ethyl ester, glyceral methacrylate, 2-hydroxyethyl methacrylamide, NVP (NVP), and polyethylene glycol monomethacrylate.Most preferred hydrophilic monomer comprises DMA, NVP and its potpourri.
Solidifying of lens material can be undertaken by any traditional method.For example, material can be used mould deposition and pass through heat, radiation, and chemistry, electromagnetic radiation is curing to be waited and combination.Preferably, with ultraviolet light or with the full spectrum of visible ray, carry out molding.More specifically, the accurate condition of applicable cured lens material depends on the material of selection and the lens of the moulding of wanting.United States Patent (USP) 4,495,313,4,680,336,4,889,664,5,039,459 and 5,540,410 disclose applicable technique, and here integral body is incorporated herein by reference.
Contact lens of the present invention can be made by any method easily.Method described in one is carried out analogue formation embolus with lathe.Mold insert is used for again forming mould conversely.Therefore, a kind of applicable lens material is placed between mould and by compression and cured resin, forms lens of the present invention subsequently.Those of ordinary skill in the art can know any other can be used for making the known method of lens of the present invention.
Claims (11)
1. a contact lens, comprises that at least one has the surface that surge pressure reduces design,
It is characterized in that described lens by use the region of different-thickness in periphery spin stabilization, described spin stabilization for by making, the front surface of lens is eccentric with respect to rear surface, prism balance, add thick lens lower limb, lower on the face support of lens, stablize leaving the prism that the lens surface formation concave surface of 90 degree meridian directions or convex surface or brachymemma rims of the lens realize.
2. lens as claimed in claim 1, further comprise at least one equal thickness vertical section in outer regions in the middle of described lens.
3. lens as claimed in claim 1, further comprise following surface: this surface has at least two different curves of slope with coupling part therebetween, at connecting portion office slope of a curve, are wherein consistent.
4. lens as claimed in claim 1, wherein its Young modulus is approximately 40 psi or larger.
5. lens as claimed in claim 2, wherein its Young modulus is approximately 40 psi or larger.
6. lens as claimed in claim 3, wherein its Young modulus is approximately 40 psi or larger.
7. lens as claimed in claim 1, wherein in lens periphery, spin stabilization comprises compares two symmetrical regions that wherein lens thickness reduces with the remaining area of lens periphery.
8. lens as claimed in claim 7, wherein said lens are toric lenses.
9. design a method for contact lens, comprise at least one surperficial step that wherein surge pressure reduces is provided,
It is characterized in that described method further comprises by the step of spin stabilization is provided with the region of different-thickness in lens periphery, described spin stabilization for by making, the front surface of lens is eccentric with respect to rear surface, prism balance, add thick lens lower limb, lower on the face support of lens, stablize leaving the prism that the lens surface formation concave surface of 90 degree meridian directions or convex surface or brachymemma rims of the lens realize.
10. method as claimed in claim 9, further comprises the step that at least one equal thickness vertical section in outer regions in the middle of described lens is provided.
11. methods as claimed in claim 9, further comprise the surperficial step that provides following: this surface has at least two different curves of slope with coupling part therebetween, at connecting portion office slope of a curve, are wherein consistent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310484548.3A CN103543539B (en) | 2004-11-12 | 2004-11-12 | A kind of method that cornea reducing contact lens wearer pollutes |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2004800443875A CN101151569B (en) | 2004-11-12 | 2004-11-12 | Methods for reducing corneal staining in contact lens wearers |
| CN201310484548.3A CN103543539B (en) | 2004-11-12 | 2004-11-12 | A kind of method that cornea reducing contact lens wearer pollutes |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2004800443875A Division CN101151569B (en) | 2004-11-12 | 2004-11-12 | Methods for reducing corneal staining in contact lens wearers |
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| Publication Number | Publication Date |
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| CN103543539A true CN103543539A (en) | 2014-01-29 |
| CN103543539B CN103543539B (en) | 2016-08-10 |
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| CN201310484548.3A Active CN103543539B (en) | 2004-11-12 | 2004-11-12 | A kind of method that cornea reducing contact lens wearer pollutes |
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Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4555372A (en) * | 1981-03-23 | 1985-11-26 | Bausch & Lomb Incorporated | Rotational molding of contact lenses |
| US5020898A (en) * | 1990-01-29 | 1991-06-04 | Schering Corporation | Contact lens for correction of astigmatism |
| US5650838A (en) * | 1995-05-04 | 1997-07-22 | Johnson & Johnson Vision Products, Inc. | Programmable smooth junctions on lenses |
| JP5051808B2 (en) * | 2000-12-11 | 2012-10-17 | 東レ株式会社 | Plastic molded product and contact lens comprising the same |
| AU2003902102A0 (en) * | 2003-05-02 | 2003-05-22 | The Institute For Eye Research | Contact lens |
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