CN101151569A - Methods for reducing corneal staining in contact lens wearers - Google Patents
Methods for reducing corneal staining in contact lens wearers Download PDFInfo
- Publication number
- CN101151569A CN101151569A CN200480044387.5A CN200480044387A CN101151569A CN 101151569 A CN101151569 A CN 101151569A CN 200480044387 A CN200480044387 A CN 200480044387A CN 101151569 A CN101151569 A CN 101151569A
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- China
- Prior art keywords
- lens
- further comprise
- cornea
- contact lens
- vinyl
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- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
- G02C7/048—Means for stabilising the orientation of lenses in the eye
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- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Eyeglasses (AREA)
- Lenses (AREA)
Abstract
The present invention provides a lens with reduced peak pressure at the low side of the eye and face of the lens wearer. The present invention provides a lens designing which can reduce or eliminate the mechanical friction of the cornea in the lens which is made from high modulus material.
Description
Technical field
The present invention relates to contact lens.Particularly, the invention provides a kind of cornea of lens wearer that makes and pollute the lens of the generation minimizing of (corneal staining).
Background technology
It is well-known adopting contact lens to proofread and correct visual sensitivity or be used for cosmetic purpose.Soft-contact lens is known, and usually, the manufacturing materials of this lens includes but not limited to hydrogel and siloxanes aquogel.
In the eyes of the normal lens wearer of using, the part of soft-contact lens covers on wearer's the cornea.By cornea pollute or after anterior corneal surface instils the diagnosis dyestuff observed keratocyte damage can betide the soft-contact lens wearer.It should be noted that especially lens mechanical friction on cornea causes polluting.This pollution is considered to a kind of indication of cornea tissue division.Lathe cutting lens are being worn in this damage, with Young modulus is the lens of 40psi (pound/square inch) or bigger material, lens with the bending of single rear surface, and center thickness, the perimeter thicknesses section, or tranverse sectional thickness or both thickness all surpass among the wearer of lens of 0.1mm and all observe.
In addition, keratocyte damage is observed in the wearer who wears the lens that front surface or rear surface have geometry in particular.The geometric configuration that goes wrong especially is that those cause occurring surperficial discontinuous in the middle outer regions of lens in the connection between the zone on lens front surface or the rear surface.Purpose of the present invention because of middle outer regions is non-optical zone outside the optical zone of lens geometric center and rims of the lens, should cover on the cornea in the zone when lens are worn on the eyes.Typically, this zone has about radius of 3.5 to 6.5mm from the lens geometric center.Finally, having thickness distribution is not that the lens in the zone of constant can cause the keratocyte damage.
Because polluting, the cornea that mechanical friction causes usually occurs in the cornea upper area most, or the cornea zone and the cornea lower zone of pupil top, or the zone of pupil below.Therefore, the cellular damage most probable appears at the cornea zone of upper eyelid or palpebra inferior below.Material and the design variation of the probability of cornea pollution with lens takes place, but can reach 50% of lens wearer.Therefore, the demand that has a kind of lens design that makes cornea pollute the incidence reduction or disappear.
Description of drawings
Fig. 1 is the lens cut-open view that the present invention amplifies.
Fig. 2 is the plan view that the lens front surface of Fig. 1 amplifies.
Summary of the invention and preferred embodiment
The invention provides a kind of cornea that is used to reduce lens wearer and pollute the method for probability and the lens that adopt the method to make.Can think that cornea that mechanical friction causes pollutes is the most often produced by the surge pressure on cornea (peak pressure), and the meaning is being born the bigger pressure of this lens area with respect to the close region cornea zone of cornea exactly.Modal, these surge pressure zones appear at the lens wearer eyelid below.Lens thickness distributes, or tranverse sectional thickness, and material modulus has caused described surge pressure with one or more in being connected of lens surface areas.
In one embodiment, the invention provides a kind of contact lens and comprise, comprise substantially, or comprise that at least one has the surface that surge pressure reduces to design.
A kind of lens design of the present invention provides an equal thickness vertical section.Wherein the meaning of " equal thickness vertical section " is to measure between lens front surface and the rear surface and along the rear surface orthogonal directions that any meridian direction of radial thickness in 45 degree of the vertical meridian direction (90-270 degree axle) along lens of outer regions evenly distributes in the middle of the lens.The equal thickness vertical section makes that the sectional thickness of the middle outer regions of lens is constant in the zone around the vertical meridian direction of lens.
Fig. 1 shows the lens 10 that embody this design.Middle outer regions 11 is presented at top (top) part and below (end) part of lens, has used the equal thickness vertical section in this part.Fig. 2 shows the plan view that shows open and flat regional 11 the lens that make progress.
The equal thickness vertical section can form desired section by biasing upper surface periphery and lower surface periphery.This section can obtain by any method for designing, includes but not limited to, in conjunction with from axle inclination curved surface or use a plurality of perimeter region.In addition, United States Patent (USP) 6,595,640 method for designing also can be used, and the content of this patent is all quoted at this.
In another interchangeable embodiment of the present invention,, discontinuous with the inclined-plane of eliminating on the rear surface in the smoothed processing in coupling part between the zones of different on one or two surface of lens.More particularly, the first order derivative in the coupling part between the sweep on the rear surface is consistent in this embodiment, that is, the bending slope of coupling part is consistent.Any method that is used for obtaining the smooth connection part includes but not limited to use conventional mathematical technique and merges two continuous zones.
Lens of the present invention are preferably stablized the orientation towards eyeball that keeps them rotatably.Suitable spin stabilization comprises prismatic stable, prismatic stable comprising, but be not limited to, the front surface that makes lens is with respect to rear surface off-centre, prismatic balance adds the thick prism lower limb, following support of lens on the face, form concave surface or convex surface and brachymemma rims of the lens at the lens surface that leaves 90 degree meridian directions.Replacedly, or stable in conjunction with prism, and lens can be dynamic stabilities.Dynamic stability comprises the thickness of minimizing lens outer surface on two symmetrical distribution zones, is increased in the thickness in two zones on the horizontal middle spindle, and attenuate, or the top region and the bottom zone of layer stripping lens.Typically, stable zone is positioned at the lens periphery, promptly around the lens non-optic portion of optical zone, but does not comprise rims of the lens and with respect to the part of geometric center lens ragged edge.
The present invention can be used for designing single vision, many focuses and toric lens.In addition, the present invention can be used for designing the lens of making of any suitable contact lens material.However, the improvement of maximum of the present invention is by using the zone of different-thickness to make the lens spin stabilization and/or be approximately 40psi (pound/square inch) with yang type modulus in the lens periphery, preferably approximately be 60psi (pound/square inch), or the material lens of higher high-modulus.
Exemplary high-modulus lens material includes, but are not limited to hydrogel, and hydrogel includes, but not limited to etafilcon A.Preferably, the present invention is used for the lens by the siloxanes aquogel making, and siloxane is a kind of like this material: comprise one or more component and one or more hydrophilic component, for example galyfilcon that contain siloxane.
One or more component and one or more hydrophilic components that contain siloxane can be that the known part of siloxanes aquogel is made in any use in the prior art.Term " component that contains siloxane " and " hydrophilic component " are not mutually exclusive, because the component that contains siloxane can have a little water wettability and hydrophilic component can comprise some siloxane.
The component that contains siloxane is at monomer, macromonomer, or include at least one [Si-O-Si-] group in the prepolymer.Preferably, the Si that is present in the component that contains siloxane surpasses 20 weight % of total molecule weight of the component that contains siloxane with the O that is connected on content, or more preferably surpasses 30 weight %.The useful component that contains siloxane preferably comprises polymerisable functional group, acrylate for example, methacrylate, acrylamide, Methacrylamide, N-vinyl lactam, N-ethernamine and styryl functional group.The example of the useful in the present invention component that contains siloxane can be 3,808,178 at U.S. Patent number; 4,120,570; 4,136,250; 4,153,641; 4,740,533; 5,034,461 and 5,070,215 and patent EP080539 in obtain.All above-mentioned patents of here quoting are incorporated herein by reference in this integral body.
The further example of the monomer that contains siloxane that is fit to is that polysiloxane group alkyl (methyl) acrylic monomers comprises, but be not restricted to, methacryloxypropyl three (trimethylsiloxy) silane, pentamethyl dimethylamino silane oxygen ylmethyl methacrylate and methyl two (trimethylsiloxy) methacryloxy methyl-monosilane.
The preferred class of component that contains siloxane is poly (organosiloxane) prepolymer, α for example, ω-dimethyl allene acyloxy propyl group dimethyl silicone polymer.Another preferred examples is mPDMS (a monomethyl acryloxy propyl group end list-normal-butyl end dimethyl silicone polymer).Useful another kind of vinyl carbonic ester or the vinyl carbamate monomer that contains siloxane that comprise of component that contains siloxane, comprise, but be not restricted to, 1,3-two [4-(ethyleneoxy carboxyl) butyl-1-yl] tetramethyl-siloxane 3-(ethylene oxy carbonyl sulfo-) propyl group-[three (trimethylsiloxy silane]; 3-[three-(trimethylsiloxy) silicyl] propyl group allyl amino formic ether; 3-[three (trimethylsiloxy) wilyl] propyl vinyl carbamate; Trimethyl silyl ethyl vinyl carbonic ester; With trimethyl silyl methyl ethylene carbonic ester.
Hydrophilic component comprises that those can provide the part with respect to the water cut of finished lens about at least 20% preferred about at least 25% when partly combining with rest activity.The hydrophilic component that is fit to weight with respect to all active parts on content can account for about 10 to about 60 weight %.About 15 arrive about 50 weight % or preferred percentage by weight about 20 to about 40 weight %.The hydrophilic monomer that can be used for preparing polymkeric substance of the present invention has at least one polymerisable double bond and at least one hydrophilic functional groups.The example of polymerizable double bond comprises acrylic; methacrylic acid group, acrylamido, methacryl amido; the fumaryl base; maleoyl, styryl, isopropenyl phenyl; O-vinyl carbonic ester; the O-vinyl carbamate, allyl, the two keys of O-vinyl acetyl group and N-vinyl lactam and N-vinyl acyl ammonia.Described hydrophilic monomer itself can be used as crosslinking chemical." acrylic acid-type " or " containing acrylic acid " monomer is those monomers that comprise acryloyl group (CR`H=CRCOX).
Wherein R is H or methyl, and R` is H, alkyl or carbonyl, with X be O or N, this is the known polymerization that is easy to, for example N,N-DMAA (DMA), the 2-hydroxy ethyl methacrylate, glyceral methacrylate, 2-hydroxyethyl methacrylamide, polyethylene glycol monomethacrylate, methacrylic acid, acrylic acid and composition thereof.
The hydrophilic vinyl-containing monomers that can incorporate hydrogel of the present invention into comprises for example N-vinyl lactam (for example N-vinyl pyrrolidone (NVP)) of following monomer, N-vinyl-N-methylacetamide, N-vinyl-N-ethyl acetamide, N-vinyl-N-ethyl-formamide, the N-vinyl formamide, N-2-hydroxyethyl vinyl carbamate, N-carboxyl-β-alanine N-vinyl esters, NVP is preferred.
Other hydrophilic monomer that can use in the present invention comprises the polyoxyethylene polyols that substitutes one or more terminal hydroxyls with the functional group that comprises polymerizable double bond.Example comprises the polyglycol that substitutes one or more terminal hydroxyls with the functional group of containing polymerizable double bond.Example comprise polyglycol and the reaction of one or more moles of terminal groups equivalents generate have one or more by the coupling part for example carbamate or ester group make the polyglycol of one or more terminal polymerizable olefinic group bondings to the polyglycol, this end-capping group comprises for example methacrylic acid isocyanate group ethyl ester (" IEM "), methacrylic anhydride, methacrylic chloride, the vinyl benzene formyl chloride, etc.
Further example is at United States Patent (USP) 5,070, disclosed hydrophilic vinylic carbonic ester or vinyl carbamate monomer and at United States Patent (USP) 4,190 in 215, disclosed hydrophilic oxazolone monomer in 277.Other hydrophilic monomer that is fit to it will be apparent to those skilled in the art that.The preferred hydrophilic monomer of introducing polymkeric substance of the present invention comprises for example N,N-DMAA (DMA), acrylic acid 2-hydroxyl ethyl ester, glyceral methacrylate, the 2-hydroxyethyl methacrylamide, N-vinyl pyrrolidone (NVP), and polyethylene glycol monomethacrylate.Most preferred hydrophilic monomer comprises DMA, NVP and its potpourri.
The curing of lens material can be undertaken by any traditional method.For example, material can use the mould deposition and pass through heat, radiation, chemistry, electromagnetic radiation curing etc. and combination thereof.Preferably, use the full spectrum of ultraviolet light or use visible light to carry out molding.More specifically, the accurate condition of suitable cured lens material depends on the material of selection and the lens of the moulding of wanting.United States Patent (USP) 4,495,313,4,680,336,4,889,664,5,039,459 and 5,540,410 disclose the technology that is fit to, and here integral body is incorporated herein by reference.
Contact lens of the present invention can be made by any method easily.A described method uses lathe to come the analogue formation embolus.Mold insert is used for forming mould conversely again.Therefore, a kind of suitable lens material is placed between mould and forms lens of the present invention by compression and cured resin subsequently.Those of ordinary skill in the art can know any other can be used for making the known method of lens of the present invention.
Claims (12)
1. a contact lens comprises that at least one has the surface that surge pressure reduces to design.
2. lens as claimed in claim 1 further comprise at least one equal thickness vertical section in the outer regions in the middle of described lens.
3. lens as claimed in claim 1 further comprise having at least two different curves of slope that have the coupling part therebetween, are consistent at connecting portion office slope of a curve wherein.
4. lens as claimed in claim 1, wherein its Young modulus is approximately 40psi or bigger.
5. lens as claimed in claim 2, wherein its Young modulus is approximately 40psi or bigger.
6. lens as claimed in claim 3, wherein its Young modulus is approximately 40psi or bigger.
7. as any one described lens in the claim 1,2,3,4,5 or 6, further comprise spin stabilization.
8. lens as claimed in claim 7, wherein spin stabilization comprises that the lens thickness of comparing on lens periphery two symmetrical distribution zones with the remaining area of lens periphery reduces.
9. lens as claimed in claim 8, wherein said lens are toric lenses.
10. method that designs contact lens comprises providing at least one to have the step on the surface that surge pressure reduces.
11., further comprise the step that at least one equal thickness vertical section in the outer regions in the middle of described lens is provided as the method for claim 10.
12., further comprise the step with the different curve of at least two slopes that have the coupling part therebetween is provided, be consistent wherein at connecting portion office slope of a curve as the method for claim 10.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310484548.3A CN103543539B (en) | 2004-11-12 | 2004-11-12 | A kind of method that cornea reducing contact lens wearer pollutes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2004/037836 WO2006054970A1 (en) | 2004-11-12 | 2004-11-12 | Methods for reducing corneal staining in contact lens wearers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310484548.3A Division CN103543539B (en) | 2004-11-12 | 2004-11-12 | A kind of method that cornea reducing contact lens wearer pollutes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101151569A true CN101151569A (en) | 2008-03-26 |
| CN101151569B CN101151569B (en) | 2013-11-20 |
Family
ID=34959619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2004800443875A Active CN101151569B (en) | 2004-11-12 | 2004-11-12 | Methods for reducing corneal staining in contact lens wearers |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1817627A1 (en) |
| JP (1) | JP4855412B2 (en) |
| CN (1) | CN101151569B (en) |
| AU (1) | AU2004324989A1 (en) |
| BR (1) | BRPI0419181B1 (en) |
| CA (1) | CA2587322C (en) |
| WO (1) | WO2006054970A1 (en) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5020898A (en) * | 1990-01-29 | 1991-06-04 | Schering Corporation | Contact lens for correction of astigmatism |
| US5650838A (en) * | 1995-05-04 | 1997-07-22 | Johnson & Johnson Vision Products, Inc. | Programmable smooth junctions on lenses |
| EP0889348A1 (en) * | 1997-07-03 | 1999-01-07 | Gérard Muller | Process for manufacturing a contact lens with axial correction having at least one stabilising boss and contact lens of this type |
| US6467903B1 (en) * | 2000-03-31 | 2002-10-22 | Ocular Sciences, Inc. | Contact lens having a uniform horizontal thickness profile |
| JP5051808B2 (en) * | 2000-12-11 | 2012-10-17 | 東レ株式会社 | Plastic molded product and contact lens comprising the same |
| AU2003221129A1 (en) * | 2002-04-12 | 2003-10-27 | Menicon Co., Ltd. | Contact lens and production method for contact lens |
| AU2003902102A0 (en) * | 2003-05-02 | 2003-05-22 | The Institute For Eye Research | Contact lens |
-
2004
- 2004-11-12 AU AU2004324989A patent/AU2004324989A1/en not_active Abandoned
- 2004-11-12 CA CA2587322A patent/CA2587322C/en active Active
- 2004-11-12 JP JP2007541154A patent/JP4855412B2/en active Active
- 2004-11-12 BR BRPI0419181A patent/BRPI0419181B1/en not_active IP Right Cessation
- 2004-11-12 CN CN2004800443875A patent/CN101151569B/en active Active
- 2004-11-12 WO PCT/US2004/037836 patent/WO2006054970A1/en active Application Filing
- 2004-11-12 EP EP04810854A patent/EP1817627A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP4855412B2 (en) | 2012-01-18 |
| JP2008520002A (en) | 2008-06-12 |
| AU2004324989A1 (en) | 2006-05-26 |
| WO2006054970A1 (en) | 2006-05-26 |
| BRPI0419181B1 (en) | 2017-03-28 |
| CA2587322A1 (en) | 2006-05-26 |
| CN101151569B (en) | 2013-11-20 |
| EP1817627A1 (en) | 2007-08-15 |
| BRPI0419181A (en) | 2007-12-18 |
| CA2587322C (en) | 2014-01-14 |
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