CN101147759A - Proprietary Chinese medicine for treating leucoderma - Google Patents

Abstract

The present invention relates to a Chinese patent medicine for effectively curing leukodermia and its preparation method. Said Chinese patent medicine is made up by using 11 Chinese medicinal materials of tribulus fruit, astragalus root, Chinese angelica root, psoralea seed, salvia root and others through a certain preparation process. Its effective rate is 96.96%.

Description

A kind ofly be used for the treatment of leukodermic Chinese patent medicine

Affiliated technical field

The present invention relates to the compatibility of Chinese patent medicine and preparation technology's technical field.Especially a kind of Chinese patent medicine that is used for the treatment of leucoderma disease and preparation method thereof.

Background technology

According to the relevant Searches of Patent Literature, do not find treatment leukodermic medicine identical and preparation method thereof at present as yet with the present invention.Vitiligo is as a kind of common skin disease, and diagnosis but is difficult to treatment easily, brings mental burden for many patients, brings influence to the work life.So, should pay much attention to, strive for that a disease eradication is in bud.The traditional Chinese medical science think vitiligo mainly be since people's voxel volume deficiency of the liver and kindey, failure of defensive QI to protect the body against pathogen, ailment said due to cold or exposure attack outward, strongly fragrant in fur, cause disharmony between QI and blood, blockage of meridian, failure of skin and muscle to be nourished, thereby cause the pigment dyspoiesis, form vitiligo." all source of disease marquis opinion " points out, the leucoderma person, and face and neck health skin and flesh complexion changed are white, and be different with yellowish pink, also sufferings not, the leucoderma of meaning.This is " ailment said due to cold or exposure is fought in skin, and the vim and vigour discord is given birth to also ".Modern medicine study prompting, vitiligo are the dysfunctions of interior tyrosine of pigment cell and tryrosinase system, cause the local skin depigmentation.Its morbidity and the reaction of self exempting from service, malnutrition and psychic trauma, some chemical factor, endocrine regulation are relevant.Still there is not specific short at present.State's internal therapy vitiligo mainly takes ultraviolet radiation, take sides such as photosensitive drug and epidermic grafting operation sends out and treats, though most of Therapeutic Method make moderate progress to the patient's condition in a short time, but in case stop treatment, also can recur, and the most drug side effect is big, life-time service returns to the patient and brings very big misery, how to address this problem relevant expert's research direction with great concentration for a long time.

Summary of the invention

A kind of Chinese patent medicine that is used for the treatment of leucoderma disease and preparation method thereof.

Purpose of the present invention to patients with vitiligo provide a kind of scientific formulation, compatibility proper, can reach that blood circulation promoting and blood stasis dispelling, wind dispelling are antipruritic, reducing swelling and alleviating pain, nourishing the liver and kidney, the effectively various leukodermic pure compound Chinese medicinal preparation that causes by a variety of causes of treatment.This product is easy to that absorption of human body, raw material resources are abundant, with low cost, good effect, have no side effect.In order to achieve the above object, the used Chinese medicine of the present invention is all conscientious with reference to " Chinese medicine voluminous dictionary " (Science and Technology of Shanghai publishing house) related content, and adopts following implementing method: in strict accordance with the present invention's prescription is 20 of Fructus Atriplicis Sibiricae 1000 grams, Fructus Fici 200 grams, the Radix Astragali 600 grams, Fructus Psoraleae 200 grams, Radix Angelicae Sinensis 200 grams, Radix Salviae Miltiorrhizae 200 grams, Herba Saussureae Involueratae 20 gram Radix Saposhnikoviaes 200 grams, Semen Cuscutae 500 grams, Realgar 15 grams, Agkistrodon.Accurately weigh, conscientiously screening, and concoct respectively.Distinguishing feature of the present invention is: prescription is rationally made and is investigated, effective ingredient content height.In the side, the Fructus Atriplicis Sibiricae dispelling pathogenic wind for improving eyesight lightly floats to dredge to reach and looses that wind is antipruritic, the Fructus Fici clearing away lung-heat, separates toxic swelling, thereby Radix Astragali tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration holder flesh are given birth to the non-specific function of exempting from service of skin ulcer energy enhancing body, Herba Saussureae Involueratae Fructus Psoraleae dispelling cold by warming the meridian, microcirculation improvement promote pigment regeneration, Chinese Angelica blood replonishing, circulation of qi promoting, invigorate blood circulation, Radix Salviae Miltiorrhizae invigorates blood circulation by becoming silted up, in Radix Saposhnikoviae dispelling wind evil, the strong natural fibre line of meat, Semen Cuscutae nourishing the liver and kidney, yin nourishing collateral dredging, Realgar is dispeled the wind, parasite killing, antibiotic, and Agkistrodon dredging the meridian, the wind that looses end table.All medicines are played supplementing QI and nourishing YIN, nourishing the liver and kidney, dispelling, collateral-activating altogether, are invigorated blood circulation

The effect that nourishes blood reaches warm lung qi nourishing skin and eliminates leukodermic purpose.Through secular clinical use, effective percentage is up to 96.96%.

The specific embodiment

A kind ofly be used for the treatment of leukodermic medicine, its implementing method comprises following method and step:

Implementing method one: 1, taking by weighing Radix Salviae Miltiorrhizae, Herba Saussureae Involueratae according to prescribed dose and mix and pulverize after cold drying, cross 10 mesh sieves, is 5-14UM be crushed to particle diameter through the ultra micro wall breaking technology, medicine one.

2, get Fructus Atriplicis Sibiricae, Fructus Fici, the Radix Astragali, Fructus Psoraleae, Radix Angelicae Sinensis, Semen Cuscutae according to prescribed dose and add 6-10 and doubly measure pure water and decoct twice continuously, be not less than total time 4 hours, refilter, filtrate is continued concentrating under reduced pressure up to becoming cream after reclaiming ethanol through precipitate with ethanol.Get medicine two.

3, with medicine one medicine two abundant mixings, make the diameter 5MM watered pill with pellet processing machine, the polishing packing promptly gets this product.For for oral administration.

4, above-mentioned (2) medicinal residues of being produced add Realgar and Agkistrodon, and 95% medical alcohol that injects 5 times of amounts soaks sealing, one week of spring and summer, 20 days autumn and winter.Be for external application.

Implementing method two: (1) takes by weighing Fructus Psoraleae, Herba Saussureae Involueratae according to prescribed dose and mixes and pulverize after cold drying, cross 10 mesh sieves, is 5-14UM be crushed to particle diameter through the ultra micro wall breaking technology, medicine one.

(2) get Fructus Atriplicis Sibiricae, Fructus Fici, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis, Semen Cuscutae according to prescribed dose and add 6-10 and doubly measure pure water and decoct twice continuously, be not less than total time 4 hours, refilter, the direct concentrating under reduced pressure of filtrate becomes clear paste, drying for standby.Get medicine two.

(3) with medicine one medicine two abundant mixings, make the diameter 5MM watered pill with pellet processing machine, the polishing packing promptly obtains this product.For for oral administration.

(4) above-mentioned (2) medicinal residues of being produced add Realgar and Agkistrodon, and 95% medical alcohol that injects 5 times of amounts soaks sealing, one week of spring and summer, 20 days autumn and winter.Be for external application.

Implementing method three: (1) takes by weighing Radix Salviae Miltiorrhizae, Herba Saussureae Involueratae according to prescribed dose and mixes and pulverized 80 mesh sieves, add 6-10 and doubly measure pure water decoction twice continuously, be not less than total time 4 hours, refilter, obtain containing the supernatant of effective ingredient behind the filtrate process precipitate with ethanol recovery ethanol, get medicine one.

(2) get Fructus Atriplicis Sibiricae, Fructus Fici, the Radix Astragali, Fructus Psoraleae, Radix Angelicae Sinensis, Semen Cuscutae according to prescribed dose and be crushed to the granule that diameter is 5-14UM through the ultra micro wall breaking technology, medicine two.

(3) medicine two abundant mixing of one medicine are mixed thoroughly, utilize pellet processing machine to make the diameter 5MM watered pill, just obtain this medicine after the polishing packing.For for oral administration.

(4) above-mentioned (1) medicinal residues of being produced add Realgar and Agkistrodon, and 95% medical alcohol that injects 5 times of amounts soaks sealing, one week of spring and summer, 20 days autumn and winter.Be for external application.

1, therapeutic effect of the present invention: observation on Clinical Application 230 examples since in October, 1999, wherein male 116 examples, woman's 114 examples, oldest 61 years old, minimum 5 years old, 23 years old mean age, year do not wait in course of disease January-20, after taking medicine of the present invention, can cure after general 2-3 course of treatment, a treatment time is 3 months.

[Therapeutic Method]: all patients use medicine of the present invention, oral medicine, and each 10 grams, a twice-daily, yellow wine is taken after mixing it with water.Medicine for external use 3-5 time on the one, is smeared the affected part, not the import eye.It is pungent to avoid the fish raw meat.

[reference standard]: white macula disappears, and the colour of skin is normal, and drug withdrawal was not recurred and is recovery from illness in 12 months; White macula disappears or area obviously dwindles through treating, and does not have bounce-back after the drug withdrawal, is produce effects; Have some improvement through treatment white macula color and luster and skin lesion area, medicine subtracts and increases the weight of again after stopping or have new white macula to occur, for effectively; Through treatment, white macula does not improve, and perhaps new white macula continues to occur or area continues to enlarge, for invalid.

[therapeutic outcome]: among the 230 routine patients, 121 people that fully recover, cure rate 52.69%; Produce effects 87 people, obvious effective rate 27.19%; Effective 15 people, effective percentage 6.52%; Invalid 7 people, inefficiency 3.04%.Total effective rate is 96.96%.

2, model case: case 1 patient's model, the woman, 13 years old, people from Shijiazhuang came me institute to go to a doctor because of back white macula half a year is surplus.The patient found before half a year that there is a white macula back part center, after increase never treatment, previously healthy, there is the vitiligo medical history in family, PE: patient's ordinary circumstance still can, the back middle upper portion has a white macula, become the about 4 * 5CM size of irregular cycle, boundary is repaid a kindness, and the edge is uneven, and the satellite rash is arranged on every side, about Semen Glycines size, peripheral pigment is normal.Tongue fur is light, thin fur, and the pulse stringy and thready pulse, RT is normal, and immune globulin and complement are all normal.Diagnosis: vitiligo.Deficiency of YIN-blood is felt the event of ailment said due to cold or exposure again.Therapeutic scheme: conventional oral external this product that adds, duty is got sun.Further consultation after the course of treatment, the satellite rash disappears on every side, and pigment is deepened around the white macula.The state of an illness is clearly better, and enjoins it to continue to take medicine.Further consultation after second each and every one, white macula the pigment island occurs in the middle of being reduced into 3 * 2CM size the course of treatment, recover normal after continuing to take 2 courses of treatment.

Case 2 patient's fourths, woman 27 years old, people from Anhui.Because of the surplus prescription on individual diagnosis in 1 year of shirtfront white macula speckle.Previously body is strong, and no family history was once done treatment, and medication is not quite clear, fail to respond to any medical treatment, existing disease progression, erythra enlarges gradually, and new rash occurs, PE: 2 of chest white maculas, boundary is still clear, about 2 * 3CM, 3 * 4CM size, the sporadic white macula of epigastrium has differed in size 12, and partial fusion is in blocks, the satellite rash is arranged, the C3 reduction clearly of having a blood test, body of the tongue is light red, less fur is not sliding, indentations at the margin of the tongue, and stringy and thready pulse is unable.The diagnosis vitiligo.Conventional oral external this product that adds, duty is got sun.Firmly embrocate, till the part is rubescent at every turn.Further consultation after the course of treatment, chest obviously is contracted to 1 * 2CM 2 day shifts, and the pigment island appears in 2 * 3CM size.Take medicine three the course of treatment potruncus disappear substantially day shift, the satellite rash disappears.Follow up a case by regular visits to so far, do not have recurrence.

Case 3 Mr.s Xia, the man, 58 years old, married, people from Huainan, Jiangsu.Calendar year 2001 examines.This patient suffered from vitiligo 32 years, and face, both legs both hands are large stretch of monolithic or merge white macula that minimum maximum accounts for 20% of body surface area as coin, and is for many years through treatment many times, unstable always to the greatest extent.All the other situations are good, do not suffer from other diseases throughout the year.Chronic illness is controlled slowly, just brings into use this product conventional therapy.During second course of treatment, begin to have the pigment island to occur, the state of an illness begins favourable turn, and 8 courses of treatment of continuous use are arranged, and the monolithic white macula disappears substantially, and women's head-ornaments, both hands skin colour are near normal.Drug withdrawal is followed up a case by regular visits to not bounce-back so far.

Claims (2)

1. one kind is used for the treatment of leukodermic Chinese patent medicine, it is characterized in that its prescription is formed by following Chinese crude drug and according to following dosage:

The Fructus Atriplicis Sibiricae 1000 gram Fructus Ficis 200 gram Radixs Astragali 600 gram Fructus Psoraleaes 200 grams

Radix Angelicae Sinensis 200 gram Radix Salviae Miltiorrhizaes 200 gram Herba Saussureae Involueratae 20 gram Radix Saposhnikoviaes 200 grams

20 of Semen Cuscutae 500 gram Realgars 15 gram Agkistrodons.

(1) 1 described preceding nine kinds of Chinese crude drugs are made the watered pill for for oral administration after processing the process of preparing Chinese medicine respectively as requested.Residual medicine dreg is standby.

2. (2) 1 described last two kinds of Chinese crude drugs and above-mentioned residual medicinal residues merge the back and add 95% ethanol and make tincture and be for external application as requested