CN101112431A - Medicine for treating amenorrhea and method for preparing the same - Google Patents
Medicine for treating amenorrhea and method for preparing the same Download PDFInfo
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- CN101112431A CN101112431A CNA2007101392594A CN200710139259A CN101112431A CN 101112431 A CN101112431 A CN 101112431A CN A2007101392594 A CNA2007101392594 A CN A2007101392594A CN 200710139259 A CN200710139259 A CN 200710139259A CN 101112431 A CN101112431 A CN 101112431A
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Abstract
The present invention relates to a drug to treat amenorrhea. The astragalus, red paeony root and leech are mixed and smashed into fine powder, water is added in earthworm, angelica, safflower, szechuan lovage rhizome, peach seed, hiraute shiny bugleweed herb, motherwort herb, rhizoma corydalis, medicinal cyathula root, danshen root and other drugs for boiling, which is filtered and concentrated into thick paste, then is added with the fine drug powder for even mixing, the product is obtained by smashing and packaging the mixture into the capsule. The drug of the present invention has the effects of benefiting qi, activating blood circulation, removing blood stasis and stimulating the menstrual flow, which is applicable to the treatment of amenorrhea, long menstrual cycle, short menstrual cycle, less amount of menstrual flow, dysmenorrhea and other gynecological disorders and has the advantages of easy administration, accurate efficacy and no toxicity or side effects etc. Proved by clinical efficacy observations of 90 cases of patients with amenorrhea, the total effective rate can reach 83.33 percent.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of amenorrhea class disease, particularly relating to a kind of is the medicine of the treatment amenorrhea of feedstock production with Chinese medicine.The invention still further relates to the preparation method of this medicine.
Background technology
Menstruation is meant the periodicity metrorrhagia that occurs with the endometrical cycle variation.The foundation of menorrhea and keep the neuroendocrine that depends on hypothalamic-pituitary-ovarian axis and regulate, and the target organ endometrium is to the periodicity reaction of gonadal hormone, wherein any one link generation obstacle all menoxenia can occur, even causes amenorrhea.Menoxenia is meant menstrual cycle, menstrual period and is unusual and follow menstrual cycle the disease of significant discomfort symptom to occur through generations such as amounts, and it is closely related that its generation and visceral dysfunction, disharmony between QI and blood cause dashing the damage of wantonly two arteries and veins.Wherein amenorrhea is the total a kind of symptom of gynecological's numerous disease, and the healthy of numerous women in serious harm.
Though amenorrhea is a kind of common gynecological disease, frequently-occurring disease, desire to reach the true not a duck soup of ideal therapeutic effect.Particularly in the amenorrhea that causes by hypothalamic-pituitary-ovarian functional disorder etc. of theoretical diagnosis according to doctor trained in Western medicine, polycystic ovary syndrome be than refractory heal a kind of.
The method of treatment amenorrhea both at home and abroad is many at present, its Chinese and western medicine mainly adopts non-steroidal anti-inflammatory drug such as Ergolactin, dexamethasone, ethinylestradiol etc. to treat, and not only poisonous side effect of medicine is big, and is difficult to effect a radical cure fully, treatment is long the course of treatment, and the state of an illness easily repeatedly.The medicine of Chinese traditional treatment amenorrhea such as MAIWEIDIHUANGWAN, GUIPI WAN, Radix Angelicae Sinensis LIUHUANG are loose etc., can treat according to the different causes of disease of different people, and what have has received curative effect preferably.It is single that but these medicines also exist treatment, and curative effect is slow, the defective that cure rate is low.
Summary of the invention
The purpose of this invention is to provide a kind of medicine that is used for the treatment of amenorrhea class disease, this medicine has benefiting QI for activating blood circulation, the effect that blood stasis dispelling is stimulated the menstrual flow, and the treatment amenorrhea can reach treating both the principal and secondary aspects of a disease, drug effect is rapid, curative effect is good purpose.
A kind of manufacturing method for above mentioned medicine is provided, and is another goal of the invention of the present invention.
To achieve the object of the present invention, for the dialectical symptom that should focus on menstrual phase, amount, color, matter and follow menstrual cycle to occur of amenorrhea, treatment then should be based on the regulating menstruation that effects a permanent cure.
Based on above aim, medicine of the present invention is that the Chinese herbal medicine by following parts by weight is that feedstock production obtains:
The Radix Astragali 20～30 Pheretimas 5～10
Radix Angelicae Sinensis 15～20 Flos Carthamis 5～10
Rhizoma Chuanxiong 10～15 Semen Persicaes 5～10
Herba Lycopi's 15～20 Herba Leonuris 20～30
Rhizoma Corydalis 10～15 Radix Paeoniae Rubra 10～15
Radix Achyranthis Bidentatae 10～15 Radix Salviae Miltiorrhizaes 10～15
Hirudo 2～5.
The medicine of above-mentioned each component can be made said dosage form on any pharmaceutics, and the preferred dosage form of the present invention is a capsule.
The concrete preparation method of above-mentioned each component being made capsule of the present invention is:
According to above-mentioned parts by weight, get the Radix Astragali, Radix Paeoniae Rubra, Hirudo mix homogeneously, be ground into 80～100 purpose fine powders; All the other medicines decoct with water 2 times, and each 0.5～1 hour, merge 2 times decocting liquid, be condensed into the thick paste of relative density 1.1～1.2 (60 ℃); The said medicine fine powder is added mix homogeneously in the thick paste, after 50～60 ℃ of dryings, be ground into 100～120 purpose medicated powder, in incapsulating, sterilization makes the capsule product.
Theory of Chinese medical science thinks that amenorrhea divides two kinds of deficiency and excesss.Void person is many because of hepatic and renal YIN deficiency, asthenia of essence and blood, or because of asthenia of qi and blood declines, sea of blood inanition, depletion of blood can descend.Reality person is many because of stagnation of QI bloody sputum, and cold condenses or the resistance of phlegm-damp harmony, blockage of vessel, and menses must not be gone.But prolonged illness must be empty, and deficiency and excess can transform mutually.In the prescription of the present invention, sweet, the tepor of the Radix Astragali, tonifying Qi and lifting yang, QI invigorating; Radix Angelicae Sinensis is sweet, hot, warm, enriches blood, invigorates blood circulation, pain relieving; Rhizoma Chuanxiong suffering, temperature, blood-activating and qi-promoting, wind-expelling pain-stopping, Xin Xianghang loose, warm promoting blood circulation, can blood circulation promoting and blood stasis dispelling with regulating menstruation, again can activating QI to alleviate the depression and pain relieving, have the function of sensible QI and blood; Pheretima becomes, trembles with fear clearing heat for calming endogenous wind, collateral dredging; Flos Carthami suffering, temperature, blood circulation promoting and blood stasis dispelling stimulates the menstrual flow, and goes into the heart, and liver blood is grasped the hot logical property of temperature of loosing, energy blood circulation promoting and blood stasis dispelling, logical regulating menstruation arteries and veins; Semen Persicae hardship, flat, blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation; Herba Lycopi's hardship, suffering, tepor, blood circulation promoting and blood stasis dispelling, line water detumescence, hot wet dissipation is logical, and is cold not dry, and property is gentle, and row and not high can soothing liver-QI gas and qualcomm meridian, has eliminating stasis and resolving masses and do not hinder the characteristics of healthy energy.Full side share, and plays benefiting QI for activating blood circulation altogether, the effect that blood stasis dispelling is stimulated the menstrual flow, and deficiency and excess is taken into account, treating both the principal and secondary aspects of a disease.Can be used for treating amenorrhea, prolonged menstruation, menstrual period are short, menstrual blood volume is few, dysmenorrhea, polycystic ovary syndrome, pelvic congestion syndrome etc.Better to the amenorrhea curative effect that causes owing to Nervous and Mental Factors, anxiety etc.
For further investigating the curative effect and the safety of Drug therapy amenorrhea of the present invention, Second Hospital of Shanxi Medical University has selected 90 routine amenorrhea patients to carry out clinical observation on the therapeutic effect.
90 routine patients are the outpatient, all are the women.21～39 years old age, average 32 ± 2.16 years old.
Diagnostic criteria
Tcm diagnosis and dialectical standard: the tcm diagnosis standard be the woman over 18 years old, menophania (primary amenorrhea) does not appear in menstruation as yet; Or menorrhea was previously once arranged, existing menolipsis has reached person more than 3 months (secondary amenorrhea).Dialectical standard is 1. amenorrhea; 2. obesity; 3. breast abdomen feeling of fullness is vomitted abundant expectoration; 4. puffiness of the face and dropsy of the feet, turbid damp are not annotated; 5. the fat or tooth of light red tongue seal, greasy fur; 6. rolling pulse.The 1. indispensable, and all the other possess any 3.
The Western medicine diagnose standard: polycystic ovary syndrome, i.e. amenorrhea is with sterile, hirsutism, obesity, bilateral ovaries increase, LH, and FSH ratio is higher, and androstenedione and testosterone that ovary is secreted are higher.
Allly meet constitutional or the secondary amenorrhea person that above-mentioned tcm diagnosis and apologist and Western medicine diagnose cause for the hypothalamic-pituitary-ovarian axis functional disorder, all can be used as the observation case.
Get rid of the case standard: 1. congenital genital development unusual or day after tomorrow of organic disease and damage and the amenorrhea that causes.2. the amenorrhea that causes because of tumor, chromosomal abnormality, conscience kidney and systemic disease etc., the psychotic.3. trimester of pregnancy, age of sucking temporary menolipsis, the menolipsis in one period after menopause in menopause or the maiden's menophania.4. the age is under-18s or person more than 45 years old, or to this drug allergy person.5. do not meet not medication person in accordance with regulations of observation caliber.
Therapeutic Method: oral medicine of the present invention, 3 times/day, 3/time, serveing on 3 months was 1 course of treatment.Evaluate curative effect after 1 course of treatment.
Criterion of therapeutical effect:
Recovery from illness: the menstruation recovery normal cycle, other symptom disappears substantially, keep 3 above persons of menstrual cycle after the drug withdrawal.
Produce effects: near normal cycle (in 40 days), rise automatically in 3 months 1 time after the drug withdrawal through the treatment menstruation.Other sx.
Effectively: through treating in 3 months menstrual onset more than 1 time, other sx.Check ovarian function LH, the FSH person of being significantly improved.
Invalid: menstruation is not seen and is risen in treating in 3 months to 6 months, and other symptom and relevant experiment wait checks all do not have improvement.
90 routine patients are after treatment, and 9 examples of fully recovering account for 10%; Produce effects 21 examples account for 23.33%; Effective 45 examples account for 50%, and invalid 15 examples account for 16.67%.Total effective rate is 83.33%.
Among the 90 routine patients, have 48 examples to be polycystic ovary syndrome, after treatment, wherein 42 examples testosterone in 20 days drops to normally, and LH, FSH also obviously improve.
The specific embodiment
Embodiment 1
Get Radix Astragali 400g, Radix Paeoniae Rubra 250g, Hirudo 50g, after choosing most impurity, cleaning screening and dry, mix homogeneously, it is standby to be ground into 80 order fine powders.
With Pheretima 120g, Radix Angelicae Sinensis 320g, Flos Carthami 150g, Rhizoma Chuanxiong 280g, Semen Persicae 100g, Herba Lycopi 350g, Herba Leonuri 600g, Rhizoma Corydalis 250g, Radix Achyranthis Bidentatae 300g, Radix Salviae Miltiorrhizae 200g join in the 6L water and decocted 1 hour, medicinal residues add same water gaging again and decocted 1 hour, merge 2 times decocting liquid, filter, be condensed into the thick paste of relative density 1.1～1.2 (60 ℃).
Add the said medicine fine powder in the thick paste, mix homogeneously after 60 ℃ of dryings, is ground into 100 purpose medicated powder, and sterilization makes the capsule product in incapsulating.
Embodiment 2
Get Radix Astragali 600g, Radix Paeoniae Rubra 300g, Hirudo 20g, after choosing most impurity, cleaning screening and dry, mix homogeneously, it is standby to be ground into 80 order fine powders.
With Pheretima 150g, Radix Angelicae Sinensis 350g, Flos Carthami 100g, Rhizoma Chuanxiong 300g, Semen Persicae 180g, Herba Lycopi 400g, Herba Leonuri 450g, Rhizoma Corydalis 300g, Radix Achyranthis Bidentatae 200g, Radix Salviae Miltiorrhizae 250g join in the 5L water and decocted 0.5 hour, medicinal residues add same water gaging again and decocted 0.5 hour, merge 2 times decocting liquid, filter, be condensed into the thick paste of relative density 1.1～1.2 (60 ℃).
Add the said medicine fine powder in the thick paste, mix homogeneously after 60 ℃ of dryings, is ground into 120 purpose medicated powder, and sterilization makes the capsule product in incapsulating.
Embodiment 3
Get Radix Astragali 500g, Radix Paeoniae Rubra 280g, Hirudo 40g, after choosing most impurity, cleaning screening and dry, mix homogeneously, it is standby to be ground into 100 order fine powders.
With Pheretima 100g, Radix Angelicae Sinensis 300g, Flos Carthami 180g, Rhizoma Chuanxiong 250g, Semen Persicae 120g, Herba Lycopi 320g, Herba Leonuri 400g, Rhizoma Corydalis 280g, Radix Achyranthis Bidentatae 250g, Radix Salviae Miltiorrhizae 300g join in the 5L water and decocted 1 hour, medicinal residues add same water gaging again and decocted 1 hour, merge 2 times decocting liquid, filter, be condensed into the thick paste of relative density 1.1～1.2 (60 ℃).
Add the said medicine fine powder in the thick paste, mix homogeneously after 50 ℃ of dryings, is ground into 120 purpose medicated powder, and sterilization makes the capsule product in incapsulating.
Embodiment 4
Get Radix Astragali 400g, Radix Paeoniae Rubra 200g, Hirudo 30g, after choosing most impurity, cleaning screening and dry, mix homogeneously, it is standby to be ground into 100 order fine powders.
With Pheretima 180g, Radix Angelicae Sinensis 400g, Flos Carthami 120g, Rhizoma Chuanxiong 200g, Semen Persicae 150g, Herba Lycopi 300g, Herba Leonuri 500g, Rhizoma Corydalis 2 00g, Radix Achyranthis Bidentatae 280g, Radix Salviae Miltiorrhizae 280g join in the 5L water and decocted 1 hour, medicinal residues add same water gaging again and decocted 0.5 hour, merge 2 times decocting liquid, filter, be condensed into the thick paste of relative density 1.1～1.2 (60 ℃).
Add the said medicine fine powder in the thick paste, mix homogeneously after 50 ℃ of dryings, is ground into 100 purpose medicated powder, and sterilization makes the capsule product in incapsulating.
Claims (3)
1. medicine for the treatment of amenorrhea is to be that crude drug prepares by following parts by weight of traditional Chinese medicines:
The Radix Astragali 20～30 Pheretimas 5～10
Radix Angelicae Sinensis 15～20 Flos Carthamis 5～10
Rhizoma Chuanxiong 10～15 Semen Persicaes 5～10
Herba Lycopi's 15～20 Herba Leonuris 20～30
Rhizoma Corydalis 10～15 Radix Paeoniae Rubra 10～15
Radix Achyranthis Bidentatae 10～15 Radix Salviae Miltiorrhizaes 10～15
Hirudo 2～5.
2. the medicine of treatment amenorrhea according to claim 1 is characterized in that described medicine is made capsule.
3. the preparation method of treatment amenorrhea medicine according to claim 2 is characterized in that according to above-mentioned parts by weight, get the Radix Astragali, Radix Paeoniae Rubra, Hirudo mix homogeneously after, be ground into 80～100 purpose fine powders; All the other medicines decoct with water 2 times, and each 0.5～1 hour, merge 2 times decocting liquid, be condensed into the thick paste of 60 ℃ of following relative densities 1.1～1.2; The said medicine fine powder is added mix homogeneously in the thick paste, after 50～60 ℃ of dryings, be ground into 100～120 purpose medicated powder, sterilization makes the capsule product in incapsulating.
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2007101392594A CN100542556C (en) | 2007-08-20 | 2007-08-20 | A kind of medicine for the treatment of amenorrhea and preparation method thereof |
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| CNB2007101392594A CN100542556C (en) | 2007-08-20 | 2007-08-20 | A kind of medicine for the treatment of amenorrhea and preparation method thereof |
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| CN100542556C CN100542556C (en) | 2009-09-23 |
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Cited By (11)
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| CN101926880A (en) * | 2010-08-30 | 2010-12-29 | 黄远吉 | Chinese medicinal composition for treating amenorrhea and endometritis of women |
| CN102085269A (en) * | 2011-01-28 | 2011-06-08 | 浙江大学 | Traditional Chinese medicine composition for treating polycystic ovary syndrome (PCOS) and application thereof |
| CN101700291B (en) * | 2009-11-11 | 2011-11-30 | 陈坤 | Blood invigorating and menses regulating medicine for treating female infertility |
| CN102349988A (en) * | 2011-10-12 | 2012-02-15 | 李承平 | Chinese patent drug for treating dysmenorrheal and irregular menstruation |
| CN102614300A (en) * | 2012-04-12 | 2012-08-01 | 张娱 | Manufacture method of Chinese medicine for regulating catamenia |
| CN103623087A (en) * | 2013-11-19 | 2014-03-12 | 靖江市明星水蛭养殖专业合作社 | Traditional Chinese medicine formula for treating irregular menstruation and preparation method of traditional Chinese medicine formula |
| CN104721316A (en) * | 2015-04-15 | 2015-06-24 | 刘卓韬 | Traditional Chinese medicine composition and acupuncture point combined application for treating amenorrhea |
| CN104906506A (en) * | 2015-06-06 | 2015-09-16 | 肖荣叶 | Traditional Chinese medicine composition for treating blood stasis and qi stagnation type amenorrhea and preparation method thereof |
| CN104940676A (en) * | 2015-06-06 | 2015-09-30 | 肖荣叶 | Traditional Chinese medicine composition for treating phlegm-dampness stagnation-type amenorrhoea and preparation method thereof |
| CN105749023A (en) * | 2016-05-11 | 2016-07-13 | 赵燕 | Traditional Chinese medicine for treating female scanty menstruation caused by tobacco and alcohol hobbies |
| CN106729203A (en) * | 2016-12-16 | 2017-05-31 | 金乡县金醫堂保健食品有限公司 | A kind of Chinese medicine for treating Hypomenorrhea |
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| CN1053189A (en) * | 1990-12-25 | 1991-07-24 | 冯虎平 | The preparation method of " promoting blood circulation and restoring paralysis pills " |
| CN1742919A (en) * | 2005-09-23 | 2006-03-08 | 北京润德康医药技术有限公司 | Shuerjing Chinese medicine preparation and preparing method thereof |
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2007
- 2007-08-20 CN CNB2007101392594A patent/CN100542556C/en not_active Expired - Fee Related
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101700291B (en) * | 2009-11-11 | 2011-11-30 | 陈坤 | Blood invigorating and menses regulating medicine for treating female infertility |
| CN101926880A (en) * | 2010-08-30 | 2010-12-29 | 黄远吉 | Chinese medicinal composition for treating amenorrhea and endometritis of women |
| CN102085269A (en) * | 2011-01-28 | 2011-06-08 | 浙江大学 | Traditional Chinese medicine composition for treating polycystic ovary syndrome (PCOS) and application thereof |
| CN102085269B (en) * | 2011-01-28 | 2012-02-22 | 浙江大学 | Traditional Chinese medicine composition for treating polycystic ovary syndrome (PCOS) and application thereof |
| CN102349988A (en) * | 2011-10-12 | 2012-02-15 | 李承平 | Chinese patent drug for treating dysmenorrheal and irregular menstruation |
| CN102614300B (en) * | 2012-04-12 | 2014-02-12 | 张娱 | Manufacture method of Chinese medicine for regulating catamenia |
| CN102614300A (en) * | 2012-04-12 | 2012-08-01 | 张娱 | Manufacture method of Chinese medicine for regulating catamenia |
| CN103623087A (en) * | 2013-11-19 | 2014-03-12 | 靖江市明星水蛭养殖专业合作社 | Traditional Chinese medicine formula for treating irregular menstruation and preparation method of traditional Chinese medicine formula |
| CN104721316A (en) * | 2015-04-15 | 2015-06-24 | 刘卓韬 | Traditional Chinese medicine composition and acupuncture point combined application for treating amenorrhea |
| CN104906506A (en) * | 2015-06-06 | 2015-09-16 | 肖荣叶 | Traditional Chinese medicine composition for treating blood stasis and qi stagnation type amenorrhea and preparation method thereof |
| CN104940676A (en) * | 2015-06-06 | 2015-09-30 | 肖荣叶 | Traditional Chinese medicine composition for treating phlegm-dampness stagnation-type amenorrhoea and preparation method thereof |
| CN105749023A (en) * | 2016-05-11 | 2016-07-13 | 赵燕 | Traditional Chinese medicine for treating female scanty menstruation caused by tobacco and alcohol hobbies |
| CN106729203A (en) * | 2016-12-16 | 2017-05-31 | 金乡县金醫堂保健食品有限公司 | A kind of Chinese medicine for treating Hypomenorrhea |
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| CN100542556C (en) | 2009-09-23 |
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