CN101112419B - Extracting technics of antineoplastic Chinese patent drug - Google Patents
Extracting technics of antineoplastic Chinese patent drug Download PDFInfo
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- CN101112419B CN101112419B CN2007101308344A CN200710130834A CN101112419B CN 101112419 B CN101112419 B CN 101112419B CN 2007101308344 A CN2007101308344 A CN 2007101308344A CN 200710130834 A CN200710130834 A CN 200710130834A CN 101112419 B CN101112419 B CN 101112419B
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- herba scutellariae
- scutellariae barbatae
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
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Abstract
The present invention discloses an extraction process of anti-tumor Chinese traditional patent medicine which has simple process and high extraction rate of the active ingredients, the steps of the process are that: the scutellaria barbata medicinal materia l is cleaned and dried in the sun, the dried scutellaria barbata is smashed into powder, water is added to generate the smashing liquid, the smashing liquid is heated to 100 DEG C for boiling for 0.5 hour and then is filtered to generate the filtrate, the filtrate is cooled to 18 DEG C, then is added with the additives for agitating for 2hours, the edible acetic acid is used for adjusting the pH value to 4.0, the filtrate is placed in still condition for 24 hours and is dehydrated and separated, the generated sediments are placed into a constant temperature tank at 40 DEG C for drying for 4 to 5 hours, then the obtained dry powder is the anti-tumor drug; the invention has the advantages that: the operation procedure is less, the used equipments are the conventional equipments on the market, the operation is carried out according to the steps of the process of the present invention strictly, the anti-tumor drug - dry powder is4 to 6 percent of the application amount of the scutellaria barbata, so the extraction rate of the active ingredients is high; the scutellaria barbata dry powder produced by the process of the present invention has significant treatment effect on the tumor diseases of human body.
Description
Technical field
The present invention relates to a kind of preparation method of Chinese patent medicine, especially utilize biological method and the extraction process of a kind of antineoplastic Chinese traditional medicine of relating to.
Background technology
Tumor, particularly malignant tumor are a kind of diseases that the human life is had substantial risk.Oncosis is being studied always, is preventing, treated to medical domain in the world at present, for example use chemical synthetic drug, chemotherapy, surgical operation, ray radiotherapy etc., although certain curative effect is arranged, but also there are many toxicity, side effects in its therapy, wherein the toxicity of chemical synthetic drug is stronger, and some vitals of human body are had the grievous injury effect; The normal cell of human body is also murdered in chemotherapy, ray radiotherapy when murdering cancerous cell; Concerning late malignant tumour, surgical operation can quicken the diffusion of cancerous cell.
Motherland's medical science has special research to antitumor, and Jiang Yi " medicine mirror pick up any lost article from the road tax " record Herba Scutellariae Barbatae is separated the Herba mesonae chinensis of snakebite; Among the people wiping out and treating insect pests and plant diseases outside the venom still used curing oncoma, and be effective in cure; The 290th page (Yao Zongfan, yellow heroic bearing are write " conventional Chinese medicine planting technology ", Golden Shield publishing house publishes, total distribution, the 10th printing January in 1998) " Herba Scutellariae Barbatae " in the Chinese herbal medicine done to introduce: Herba Scutellariae Barbatae, another name: narrow leaf Herba Scutellariae indicae, toothbrush grass, and head grass, Herba Scutellariae Darbatae etc.; Section belongs to: be Labiatae Scutellaria plant; General introduction: Herba Scutellariae Barbatae has heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain and anticancer function with the herb hyoscine, cures mainly tumor, hepatitis, hepatitis interstitialis chronica ascites, lung abscess etc. and levies, especially to effects such as pulmonary carcinoma, gastric cancer, the esophageal carcinoma, cervical cancers better.But since the general compatibility of traditional Chinese herbal medicine adopt decoct, concentrate, extraction, spraying, dry, honey refining etc. carry out the treatment of soup clothes, impurity and effective ingredient are mixed in the soup, what cause that patient obeys takes effect slowly.Simultaneously, the taste of decoction also makes some patients forbidding.
Summary of the invention
The present invention is directed to the defective of above-mentioned existence, proposed the extraction process of the antineoplastic Chinese traditional medicine that a kind of technology is simple, the effective ingredient extraction is high.
Technical scheme of the present invention is achieved in that a kind of extraction process of antineoplastic Chinese traditional medicine, and this operating procedure is:
1, get a certain amount of Herba Scutellariae Barbatae, carry out routine and clean in stainless steel tank, taking-up is dried standby;
2, standby Herba Scutellariae Barbatae is put into cutter formula vertical shaft pulverizer and pulverize, smashing fineness 200 orders-250 order, the water that is incorporated as 10 times of Herba Scutellariae Barbatae weight again mixes, and produces to pulverize liquid;
3, will pulverize liquid and put into stainless-steel pan, and heat to 100 ℃ and boiled 0.5 hour, then add the filtration cloth bag, and open baiting valve then and filter, produce filtrate at the blowing valve port;
4, in aseptic temperature control workshop, filtrate is poured in the stainless-steel pan with blender apparatus, be cooled to 18 ℃, add a certain amount of protease, cellulase and amylase again, under the condition of 30 rev/mins of rotating speeds, stirred 2 hours, and constantly use the tablet vinegar acid for adjusting pH value, and to pH value 4.0, static 24 hours;
5, in aseptic temperature control workshop, with static liquid put into centrifugal dehydrator dewater separate after, the precipitate that is produced is put in the electric drying oven with forced convection and to be set constant temperature and carried out dry 4-5 hour for 40 ℃, and at this moment the dry powder of Qu Chuing is antineoplastic agent, and this finished weight is Herba Scutellariae Barbatae weight 4-6%.
Further, the extraction process of aforementioned a kind of antineoplastic Chinese traditional medicine, the addition of the protease that adds in the step 4 is the 0.2-0.5% of Herba Scutellariae Barbatae weight.
Further, the extraction process of aforementioned a kind of antineoplastic Chinese traditional medicine, the addition of the cellulase that adds in the step 4 is the 0.2-0.5% of Herba Scutellariae Barbatae weight.
Further, the extraction process of aforementioned a kind of antineoplastic Chinese traditional medicine, the diastatic addition of adding in the step 4 is the 0.1-0.3% of Herba Scutellariae Barbatae weight.
Described raw material sources in the present invention: Herba Scutellariae Barbatae is purchased by Chinese crude drugs at different levels shop; Protease, cellulase, amylase are buied from Wuxi, Jiangsu Province enzyme preparation factory; Alimentary acetic acid is bought from Nantong Acetic Acid factory.Described equipment source: cutter formula vertical shaft pulverizer is that Shanghai Chinese traditional medicine machine factory produces; Electric drying oven with forced convection is Lianyungang, Jiangsu Province medical machinery instrument factory production product; Stainless steel tank, stainless-steel pan, the stainless-steel pan with blender apparatus, centrifugal dehydrator are all bought from Suzhou City chemical industry equipment supply and marketing company.
Advantage of the present invention is:
1. operation sequence is few, and device therefor is a conventional equipment on the market, and technology is simple thus;
2. carry out operation in strict accordance with processing step of the present invention, antineoplastic agent-dry powder is the 4-6% of Herba Scutellariae Barbatae input amount, thus effective ingredient extraction height;
The specific embodiment
Embodiment one:
A kind of extraction process of antineoplastic Chinese traditional medicine, this operating procedure is:
1. get 10 kilograms Herba Scutellariae Barbatae, carry out routine and clean in stainless steel tank, taking-up is dried standby;
2. standby Herba Scutellariae Barbatae is put into cutter formula vertical shaft pulverizer and pulverize, smashing fineness 200 orders-250 order adds 100 kilograms of mixing of water again, produces to pulverize liquid;
3. will pulverize liquid and put into stainless-steel pan, and heat to 100 ℃ and boiled 0.5 hour, then add the filtration cloth bag, and open baiting valve then and filter, produce filtrate at the blowing valve port;
4. in aseptic temperature control workshop, filtrate is poured in the stainless-steel pan with blender apparatus, be cooled to 18 ℃, add 0.02 kilogram protease, 0.05 kilogram cellulase and 0.01 kilogram amylase again, under the condition of 30 rev/mins of rotating speeds, stirred 2 hours, and constantly use the tablet vinegar acid for adjusting pH value, and to pH value 4.0, static 24 hours;
5. in aseptic temperature control workshop, with static liquid put into centrifugal dehydrator dewater separate after, the precipitate that is produced is put in the electric drying oven with forced convection and to be set constant temperature and carried out drying 4 hours for 40 ℃, and at this moment the dry powder of Qu Chuing (Herba Scutellariae Barbatae elite) is antineoplastic agent, and this finished weight is 0.4 kilogram.
Embodiment two:
A kind of extraction process of antineoplastic Chinese traditional medicine, this operating procedure is:
1. get 15 kilograms Herba Scutellariae Barbatae, carry out routine and clean in stainless steel tank, taking-up is dried standby;
2. standby Herba Scutellariae Barbatae is put into cutter formula vertical shaft pulverizer and pulverize, smashing fineness 200 orders-250 order adds 150 kilograms of mixing of water again, produces to pulverize liquid;
3. will pulverize liquid and put into stainless-steel pan, and heat to 100 ℃ and boiled 0.5 hour, then add the filtration cloth bag, and open baiting valve then and filter, produce filtrate at the blowing valve port;
4. in aseptic temperature control workshop, filtrate is poured in the stainless-steel pan with blender apparatus, be cooled to 18 ℃, add 0.075 kilogram protease, 0.03 kilogram cellulase and 0.015 kilogram amylase again, under the condition of 30 rev/mins of rotating speeds, stirred 2 hours, and constantly use the tablet vinegar acid for adjusting pH value, and to pH value 4.0, static 24 hours;
5. in aseptic temperature control workshop, with static liquid put into centrifugal dehydrator dewater separate after, the precipitate that is produced is put in the electric drying oven with forced convection and to be set constant temperature and carried out drying 5 hours for 40 ℃, and at this moment the dry powder of Qu Chuing (Herba Scutellariae Barbatae elite) is antineoplastic agent, and this finished weight is 0.75 kilogram.
Embodiment three:
A kind of extraction process of antineoplastic Chinese traditional medicine, this operating procedure is:
1. get 20 kilograms Herba Scutellariae Barbatae, carry out routine and clean in stainless steel tank, taking-up is dried standby;
2. standby Herba Scutellariae Barbatae is put into cutter formula vertical shaft pulverizer and pulverize, smashing fineness 200 orders-250 order adds 200 kilograms of mixing of water again, produces to pulverize liquid;
3. will pulverize liquid and put into stainless-steel pan, and heat to 100 ℃ and boiled 0.5 hour, then add the filtration cloth bag, and open baiting valve then and filter, produce filtrate at the blowing valve port;
4. in aseptic temperature control workshop, filtrate is poured in the stainless-steel pan with blender apparatus, be cooled to 18 ℃, add 0.07 kilogram protease, 0.07 kilogram cellulase and 0.04 kilogram amylase again, under the condition of 30 rev/mins of rotating speeds, stirred 2 hours, and constantly use the tablet vinegar acid for adjusting pH value, and to pH value 4.0, static 24 hours;
5. in aseptic temperature control workshop, with static liquid put into centrifugal dehydrator dewater separate after, the precipitate that is produced is put in the electric drying oven with forced convection and to be set constant temperature and carried out drying 4.5 hours for 40 ℃, and at this moment the dry powder of Qu Chuing (Herba Scutellariae Barbatae elite) is antineoplastic agent, and this finished weight is 1.2 kilograms.
Embodiment of the invention content helps to understand the present invention; but do not limit content of the present invention, every operating procedure is simple combination, or is considered to equivalent substitution; or utilize the processing of this finished product powder to manufacture capsule, pill, injection etc., all drop in effective protection domain of the present invention.
Medical record is introduced
The antineoplastic agent of explained hereafter of the present invention was developed 2 years, clinical use 100 examples, effective percentage 95%, cure rate 60%.
The curative effect that is produced behind the antineoplastic agent below by the oral employing of patient explained hereafter of the present invention is further described.
Medical record one:
Chen Jingen, the man, 61 years old, ID (identity number) card No.: 320524194703142192, Suzhou, Jiangsu Wuzhong District Mu Du people from town, suffered from large bowel neoplasm before 3 years, be positioned at ieoocolon, the tumor scope: totally two of 2X2 centimetres, often feel abdominal pain, defecate 3-4 every day, once in Suzhou, Shanghai, seek medical advice in ground such as Henan, obstinate, begin to take the Herba Scutellariae Barbatae dry powder that technology of the present invention is made on January 5th, 2007, dose: every day three times, each 1.3 grams, two months is a course of treatment, serve on two courses of treatment, existing abdominal pain disappears, and the tumor scope is contracted to one of 0.5X1 centimetre on inspection, and another disappears.
Medical record two:
Wang Xiaomin, woman, 56 years old, ID (identity number) card No.: 320524195208112921, tumor of bladder was made a definite diagnosis 5 years, and dribbling urination is not smooth, with the hypodynia sense of discomfort, take the Herba Scutellariae Barbatae dry powder that technology of the present invention is made in July, 2006, dose: every day three times, each 1.3 grams, two months is a course of treatment, only obey a course of treatment, now all are normal, do not have the difference sensation.
Medical record three:
Zhuan Xinggen, man, 64 years old, ID (identity number) card No.: in February, 320524194512072931,2005, diagnosis right side, First People's Hospital, Suzhou City renal carcinoma, be convenient to time month to have carried out right side kidney resection operation, leave hospital April then, do not do chemotherapy, radiotherapy, take the Herba Scutellariae Barbatae dry powder that technology of the present invention is made therebetween, dose: every day three times, each 1.3 grams, two months is a course of treatment, obey three courses of treatment altogether, consolidate effect of surgical treatment, check through the related hospitals check: carcinoembryonic antigen is normal.Now this comrade provides the elderly with opportunities to enjoy themselves, and actively drops in the rural economic construction, is new socialist countryside construction service.
Medical record four:
Wang Xingfu, man, 51 years old, ID (identity number) card No.: 320524570105663, chronic pharyngolaryngitis 15 years, not treatment in time, being converted into the throat tumor has 2 years history, conscious dysphagia, bottleneck throat has foreign body sensation, itching of the throat or pain, hoarseness is taken the Herba Scutellariae Barbatae dry powder that technology of the present invention is made in March, 2006, dose: every day three times, each 1.3 grams, two months is a course of treatment, obeys two courses of treatment altogether, check that through related hospitals bottleneck throat has not had tumor, cure, do not recur over one year.
Claims (4)
1. the extraction process of an antineoplastic Chinese traditional medicine, it is characterized in that: this operating procedure is:
A. get a certain amount of Herba Scutellariae Barbatae, carry out routine and clean in stainless steel tank, taking-up is dried standby;
B. standby Herba Scutellariae Barbatae is put into cutter formula vertical shaft pulverizer and pulverize, smashing fineness 200 orders-250 order, the water that is incorporated as 10 times of Herba Scutellariae Barbatae weight again mixes, and produces to pulverize liquid;
C. will pulverize liquid and put into stainless-steel pan, and heat to 100 ℃ and boiled 0.5 hour, then add the filtration cloth bag, and open baiting valve then and filter, produce filtrate at the blowing valve port;
D. in aseptic temperature control workshop, filtrate is poured in the stainless-steel pan with blender apparatus, be cooled to 18 ℃, add a certain amount of protease, cellulase and amylase again, under the condition of 30 rev/mins of rotating speeds, stirred 2 hours, and constantly use the tablet vinegar acid for adjusting pH value, and to pH value 4.0, static 24 hours;
E. in aseptic temperature control workshop, with static liquid put into centrifugal dehydrator dewater separate after, the precipitate that is produced is put in the electric drying oven with forced convection and to be set constant temperature and carried out dry 4-5 hour for 40 ℃, and at this moment the dry powder of Qu Chuing is antineoplastic agent, and this finished weight is Herba Scutellariae Barbatae weight 4-6%.
2. the extraction process of antineoplastic Chinese traditional medicine according to claim 1, it is characterized in that: described protease addition is the 0.2-0.5% of Herba Scutellariae Barbatae weight.
3. the extraction process of antineoplastic Chinese traditional medicine according to claim 1, it is characterized in that: described cellulase addition is the 0.2-0.5% of Herba Scutellariae Barbatae weight.
4. the extraction process of antineoplastic Chinese traditional medicine according to claim 1, it is characterized in that: described amylase addition is the 0.1-0.3% of Herba Scutellariae Barbatae weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007101308344A CN101112419B (en) | 2007-08-24 | 2007-08-24 | Extracting technics of antineoplastic Chinese patent drug |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2007101308344A CN101112419B (en) | 2007-08-24 | 2007-08-24 | Extracting technics of antineoplastic Chinese patent drug |
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| CN101112419A CN101112419A (en) | 2008-01-30 |
| CN101112419B true CN101112419B (en) | 2010-12-08 |
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| CN2007101308344A Expired - Fee Related CN101112419B (en) | 2007-08-24 | 2007-08-24 | Extracting technics of antineoplastic Chinese patent drug |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103405575A (en) * | 2013-08-13 | 2013-11-27 | 吴中区胥口精益生物医药研究所 | Composite essence for reducing blood pressure and extraction process thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1891239A (en) * | 2005-07-07 | 2007-01-10 | 福州安素酶工程开发有限公司 | Method for preparing Chinese herb medicine utilizing enzyme preparation |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1891239A (en) * | 2005-07-07 | 2007-01-10 | 福州安素酶工程开发有限公司 | Method for preparing Chinese herb medicine utilizing enzyme preparation |
Non-Patent Citations (6)
| Title |
|---|
| 孙晓雪等.仙人掌多糖提取过程中脱蛋白方法的研究.天然产物研究与开发19 1.2007,19(1),117-119，122. |
| 孙晓雪等.仙人掌多糖提取过程中脱蛋白方法的研究.天然产物研究与开发19 1.2007,19(1),117-119,122. * |
| 祝勇军等.半枝莲抗肿瘤作用研究进展.中国中医急症15 5.2006,15(5),533-535. |
| 祝勇军等.半枝莲抗肿瘤作用研究进展.中国中医急症15 5.2006,15(5),533-535. * |
| 许明淑等.酶法强化中药提取的研究进展.中国中医药信息杂志12 12.2005,12(12),37-39. |
| 许明淑等.酶法强化中药提取的研究进展.中国中医药信息杂志12 12.2005,12(12),37-39. * |
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Granted publication date: 20101208 Termination date: 20170824 |