CN101099713A - Method for processing traditional Chinese medicine super-micro instant particle - Google Patents
Method for processing traditional Chinese medicine super-micro instant particle Download PDFInfo
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- CN101099713A CN101099713A CNA2007100296710A CN200710029671A CN101099713A CN 101099713 A CN101099713 A CN 101099713A CN A2007100296710 A CNA2007100296710 A CN A2007100296710A CN 200710029671 A CN200710029671 A CN 200710029671A CN 101099713 A CN101099713 A CN 101099713A
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Abstract
The present invention relates to a processing method of Chinese medicine ultrafine quick-dissolving granules. It is characterized by that said processing method includes the following steps: soaking single Chinese medicine decocting pieces, filtering, concentrating filtrate, drying and granulating. For Chinese medicine ultrafine decocting pieces containing volatile oil after the above-mentioned soaking steps a volatile oil extraction step can be added.
Description
Technical field
The present invention relates to the Chinese medicine manufacture field, be specifically related to a kind of method that the Chinese medicine ultramicro decoction piece is processed into instant granular.
Background technology
Chinese medicine is taken the two kinds of forms that are generally, and is brewed into decoction with high temperature after the first is soaked the prepared slices of Chinese crude drugs and directly takes, though the pharmaceutically active ingredient dissolution rate is higher in this mode, drug effect is also better, can carry out compatibility according to patient's concrete condition again, but the process that boils bothers very, carry very inconvenient; Second method is to utilize process means to be processed into Chinese patent medicine the prepared slices of Chinese crude drugs, though taking convenience, but just better to some comparatively typical case effect, and patient's situation varies, fixed compatibility can not effectively be suited the remedy to the case according to patient's concrete situation.Have at present and will adopt superfine communication technique make it become ultramicro decoction piece after the prepared slices of Chinese crude drugs drying, make particulate processing method again, this processing is to c}, the processing that the tablet material is carried out improves, can improve the dissolution rate of medicine active ingredient, but because fine powder or granule after the processing still are crude drug, there is not extraction procedure in its technology, thereby must soak more than 20-30 minute with boiled water when taking, take concoction and take, especially for the medical material that contains the Shan that volatilizees, patient does not have special equipment and means to extract, and drug effect will be hanged down relatively; Because weight, the volume of its granule are still bigger, are not easy to packing, store and transportation in addition.
Summary of the invention
Technical problem to be solved by this invention is that the decoction pieces to superfine communication technique processing is that the Chinese medicine ultramicro decoction piece is done further processing, and the extraction ratio of its property of medicine and active ingredient is further improved, and more convenient patient takes, and is convenient to packing, stores and transportation.
The present invention solves above-mentioned technical problem by following technical scheme.It is characterized in that it is that the single medicinal material ultramicro decoction piece is passed through to soak, filter, then that filtrate is concentrated, dry, granulation forms; After immersion, also be provided with volatile oil extraction and enclose operation for medicine ultramicro decoction piece among containing volatile oil.Wherein the immersion of Chinese medicine ultramicro decoction piece is that it is loaded in the muslin bag, and with ultramicro decoction piece deal 4-10 hot-water soak doubly, water temperature is 70-100 ℃, and the time is 10-40 minute; Containing among the volatilization Shan that the volatile oil of medicine ultramicro decoction piece extracts is with its soak volatile oil extractor of packing into, distill collection volatile oil 4-6 hour.Inclusion essential oil is that its ratio is 1: 5-1: 10 with β one cyclodextrin inclusion compound volatilization Shan.Drying process is not contain the soak and the residue medicinal liquid employing vacuum concentration that contains after volatile oil composition Chinese medicine ultramicro decoction piece extracts the volatilization Shan, spray drying of the Chinese medicine ultramicro decoction piece of volatile oil composition.Contain the more person of saccharide composition and adopt vacuum drying, all the other adopt spray drying, and the person adopts lyophilization to contain the volatile component.Granulation process is to add the dextrin of 5-20% or the ultramicro medicine powder of this medical material in exsiccant medicated powder, and mixing is made binding agent with the ethanol of 30-95%, crosses the 5-15 eye mesh screen, in 30-70 ℃ of drying, after moisture is lower than 10%, with 12-40 mesh sieve granulate.
The present invention has following technique effect:
1) still keeps all characteristics of crude drug ultramicro decoction piece, still can save the medical material consumption greatly, improved the stripping quantity of active ingredient, accelerated the dissolution rate of active ingredient.
2) because the stripping of having taked to heat, concentrate, operations such as drying, granulation, so taking dose still less, dose is equivalent to the 30-40% of ultramicro decoction piece, the 10-20% that is equivalent to the Chinese medicine decoction pieces, especially adopted the volatilization Shan to extract and inclusion method for containing volatilization Shan class medical material, the utilization rate of its active ingredient is higher.As one 20% tradition prescription, adopt firm ultramicro decoction piece, consumption is about 100g, adopts super-micro instant particle then only need take 30-40g (leaching rate behind the super-micro instant particle is by 30%, and general leaching rate is 10-50%).If estimate by the Chinese medicine prescription amount, Coming-of-Age Day consumption generally can not surpass 100g, the dose of super-micro instant particle can be controlled in 15.30g so, has saved Chinese crude drug greatly.
3) dissolving is quick, easy to carry, can be according to directly taking after mixing it with water behind the needs of patients compatibility, and the application that has overcome Chinese patent medicine has certain limitation and the defective of the hard to bear system of outpatient service prescription Chinese medicine, greatly facilitates the patient.
4) also be improved at aspects such as packing, storage, transportations.The Chinese medicine decoction pieces has all brought inconvenience for packing, storage, transportation etc. because its consumption is big, and medical material becomes definite shape; Though the Chinese medicine ultramicro decoction piece has greatly improved, its weight, volume are still bigger, and the present invention's shape no matter, or weight, volume, all are better than prior art, help it packing, store and transport etc.
5) preparation condition of the present invention and equipment requirements are all very low, are better than the Chinese medicine tradition and extract.The Chinese medicine tradition is extracted palpus high temperature (more than 100 ℃), long (1-4 hour) and high-temperature high-pressure apparatus of time, and the present invention only needs eliminating cold for resuscitation water logging bubble to get final product in 20-40 minute.
Description of drawings
Fig. 1 is a process chart of the present invention.
The specific embodiment
The present invention is further improvement that the ultramicro decoction piece that has been processed into is done and perfect, because patient's there's a widespread conviction that outpatient service prescription Chinese medicine, and the application of commercially available Chinese patent medicine has certain limitation, how both to seek take, easy to carry, having the Chinese medicine preparation of outpatient service decoction prescription Chinese medicine characteristics again, will be the focus in present Chinese medicine market.
The Chinese medicine ultramicro decoction piece has very big breakthrough on the former basis, and it has exempted the prepared slices of Chinese crude drugs fully must decoct the loaded down with trivial details program that boils, and greatly facilitates the patient.But this method still has the not place of person of modern times's meaning in application.The present invention solves this, to overcome the defective of prior art.Its processing method is that the single medicinal material ultramicro decoction piece is passed through to soak, filter, and then that filtrate is concentrated, dry, granulation forms.Concrete processing step and technical parameter are:
1) soaks: ultramicro decoction piece is loaded in the muslin bag, use its deal 4-10 hot-water soak doubly then, do not contain the volatilization Shan and be respectively 80-100 ℃ and 70-90 ℃ with the immersion water temperature that contains the ultramicro decoction piece of the Shan that volatilizees, the time is 10-40 minute, must stir in the immersion, make its abundant stripping active ingredient.
2) filter: the ultramicro decoction piece through soaking in the muslin bag is carried out press filtration.
3) volatile oil extracts and enclose: this technology is only at the ultramicro decoction piece that contains volatile oil.Its process is: it is with its filtrate volatilization Shan extractor of packing into that the volatilization Shan extracts, and distill 4-6 hour, collects the Shan that volatilizees.Clathrate process is the volatile oil that is extracted with β one cyclodextrin inclusion compound, and the enclose ratio is 1: 5-1: 10.Can guarantee to contain the drug effect of the medical material of the Shan that volatilizees like this.
4) drying: do not contain the soak convection drying of the ultramicro decoction piece of the Shan that volatilizees, after the soak that contains the ultramicro decoction piece of volatile oil extracts the Shan that volatilizees, dry again behind the remaining medicinal liquid employing vacuum concentration.The concentrated solution that contains the more Chinese medicine ultramicro decoction piece of saccharide composition adopts vacuum drying; The concentrated solution that contains the less Chinese medicine ultramicro decoction piece of saccharide composition adopts spray drying; The concentrated solution that contains the Chinese medicine ultramicro decoction piece of volatile component adopts lyophilization.
5) granulate: the medicine that contains the Shan that volatilizees directly adds the dextrin of 5-20% or the ultramicro medicine powder of this medical material, mixing through immersion, medicated powder concentrated, dry gained; For the ultramicro decoction piece that contains volatile oil then be Jiang Bao with after the volatilization Shan join in the dry medicated powder of former remaining identical composition, add the dextrin of 5-20% or the ultramicro medicine powder of this medical material again, mixing, all use the ethanol of 30-95% as binding agent then, cross 5-15 day screen cloth, in 30-70 ℃ of drying, treat that moisture is lower than 10% after, with 12-40 mesh sieve granulate.
6) packing: adopt the amount of 0.5-10 gram to pack, be convenient to compatibility.
The convenience that the present invention had both had Chinese patent medicine and possessed is convenient to produce by batch and sell, and has the characteristics of outpatient service decoction prescription again.Because being single medicinal material, it constitutes, the doctor can carry out plus minus compatibility according to patient's needs, and packing is by general tcm prescription configuration, need not weigh in the pharmacy, can directly send out medicine, reduce pharmacy worker's labor intensity, also reduce error rate simultaneously by the explanation in the packaging bag, patient only need put together various drug particles and just directly brew and can take, and greatly facilitates patient.
Claims (10)
1, a kind of Chinese medicine super-micro instant particle processing method, it is characterized in that it be with the single medicinal material ultramicro decoction piece by soaking, filter, and then with filtrate concentrate, dry, granulating becomes the Chinese medicine super-micro instant particle.
2, Chinese medicine super-micro instant particle processing method according to claim 1, the immersion operation that it is characterized in that not containing the Chinese medicine ultramicro decoction piece of volatile oil is that it is loaded in the muslin bag, with the hot-water soak that 4-10 doubly measures, water temperature is 80-100 ℃, and the time is 10-40 minute.
3, Chinese medicine super-micro instant particle processing method according to claim 1, it is characterized in that the immersion operation for the Chinese medicine ultramicro decoction piece that contains volatile oil is that it is loaded in the muslin bag, with the hot-water soak that 4-10 doubly measures, water temperature is 70-90 ℃, and the time is 10-40 minute.
4, Chinese medicine super-micro instant particle processing method according to claim 3 is characterized in that extracting and the enclose operation for also being provided with volatile oil after the immersion operation that contains medicine ultramicro decoction piece among the volatile oil.
5, Chinese medicine super-micro instant particle processing method according to claim 4, it is characterized in that for containing among the volatile oil volatile oil abstraction process of medicine ultramicro decoction piece be that the leachate after soaking is packed in the volatilization Shan extractor, distilled 4-6 hour, and collected the volatilization Shan; Its enclose operation is that ratio is 1: 5-1: 10 with β one cyclodextrin inclusion compound volatile oil.
6, according to claim 1 or 2 or 3 described Chinese medicine super-micro instant particle processing methods, it is characterized in that filtering operation is press filtration.
7,, it is characterized in that the concentrated solution that contains the more Chinese medicine ultramicro decoction piece of saccharide composition adopts vacuum drying according to claim 1 or 2 or 3 described Chinese medicine super-micro instant particle processing methods.
8,, it is characterized in that the concentrated solution that contains the less Chinese medicine ultramicro decoction piece of saccharide composition adopts spray drying according to claim 1 or 2 or 3 described Chinese medicine super-micro instant particle processing methods.
9, according to claim 1 or 2 or 3 described Chinese medicine super-micro instant particle processing methods, the concentrated solution that it is characterized in that containing the Chinese medicine ultramicro decoction piece of volatile component adopts lyophilization.
10, according to claim 1 or 2 or 3 or 4 described Chinese medicine super-micro instant particle processing methods, it is characterized in that granulation process is: in exsiccant medicated powder, add the dextrin of 5-20% or the ultramicro medicine powder of this medical material and mix, the ethanol of reuse 30-95% is as binding agent, cross the 5-15 eye mesh screen, in 30-70 ℃ of drying, after moisture is lower than 10%, with 12-40 mesh sieve granulate.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100296710A CN101099713A (en) | 2007-08-09 | 2007-08-09 | Method for processing traditional Chinese medicine super-micro instant particle |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2007100296710A CN101099713A (en) | 2007-08-09 | 2007-08-09 | Method for processing traditional Chinese medicine super-micro instant particle |
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| CN101099713A true CN101099713A (en) | 2008-01-09 |
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| CNA2007100296710A Withdrawn CN101099713A (en) | 2007-08-09 | 2007-08-09 | Method for processing traditional Chinese medicine super-micro instant particle |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239413A (en) * | 2013-05-27 | 2013-08-14 | 内蒙古大漠药业股份有限公司 | Method for large-scale production of traditional Chinese medicine powder particles |
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2007
- 2007-08-09 CN CNA2007100296710A patent/CN101099713A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103239413A (en) * | 2013-05-27 | 2013-08-14 | 内蒙古大漠药业股份有限公司 | Method for large-scale production of traditional Chinese medicine powder particles |
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