CN101098855B - 3-[2-(3-酰氨基-2-氧代-2h-吡啶-1-基)-乙酰氨基]-4-氧代-戊酸衍生物及其作为天冬氨酸特异性半胱氨酸蛋白酶抑制剂的用途 - Google Patents
3-[2-(3-酰氨基-2-氧代-2h-吡啶-1-基)-乙酰氨基]-4-氧代-戊酸衍生物及其作为天冬氨酸特异性半胱氨酸蛋白酶抑制剂的用途 Download PDFInfo
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- 0 *=C([C@](Cc1ccccc1)N(C=CC=C1NC(c(c(Cl)ccc2)c2Cl)O)C1=[*+])N[C@@](CC(O)=O)C(COc(c(F)c(cc1F)F)c1F)=O Chemical compound *=C([C@](Cc1ccccc1)N(C=CC=C1NC(c(c(Cl)ccc2)c2Cl)O)C1=[*+])N[C@@](CC(O)=O)C(COc(c(F)c(cc1F)F)c1F)=O 0.000 description 7
- WZZOGVWXGGUWJV-UHFFFAOYSA-N CC(C)(C)OC(CN(C=CC=C1NC(OCc2ccccc2)=O)C1=O)=O Chemical compound CC(C)(C)OC(CN(C=CC=C1NC(OCc2ccccc2)=O)C1=O)=O WZZOGVWXGGUWJV-UHFFFAOYSA-N 0.000 description 1
- FINLRDCILRBHJM-FQEVSTJZSA-N CC(C)(C)OC([C@H](Cc1c[n](C(OC(C)(C)C)=O)c2c1cccc2)N(C=CC=C1C(O)=O)C1=O)=O Chemical compound CC(C)(C)OC([C@H](Cc1c[n](C(OC(C)(C)C)=O)c2c1cccc2)N(C=CC=C1C(O)=O)C1=O)=O FINLRDCILRBHJM-FQEVSTJZSA-N 0.000 description 1
- ZCMRALNVNNANSW-KEKNWZKVSA-N OC(CC(C(CF)=O)NC([C@H](CCc1ccccc1)N(C=CC=C1NC(c2ccccc2)=O)C1=O)=O)=O Chemical compound OC(CC(C(CF)=O)NC([C@H](CCc1ccccc1)N(C=CC=C1NC(c2ccccc2)=O)C1=O)=O)=O ZCMRALNVNNANSW-KEKNWZKVSA-N 0.000 description 1
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63092604P | 2004-11-24 | 2004-11-24 | |
| US60/630,926 | 2004-11-24 | ||
| PCT/US2005/042139 WO2006057961A1 (en) | 2004-11-24 | 2005-11-21 | 3-[2-(3-acylamino-2-oxo-2h-pyridin-1-yl)-acetylamino]-4-oxo-pentanoic acid derivatives and their use as caspase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101098855A CN101098855A (zh) | 2008-01-02 |
| CN101098855B true CN101098855B (zh) | 2012-06-06 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2005800463680A Expired - Fee Related CN101098855B (zh) | 2004-11-24 | 2005-11-21 | 3-[2-(3-酰氨基-2-氧代-2h-吡啶-1-基)-乙酰氨基]-4-氧代-戊酸衍生物及其作为天冬氨酸特异性半胱氨酸蛋白酶抑制剂的用途 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8362043B2 (https=) |
| EP (1) | EP1833794B1 (https=) |
| JP (2) | JP5055129B2 (https=) |
| KR (1) | KR20070086610A (https=) |
| CN (1) | CN101098855B (https=) |
| AT (1) | ATE543803T1 (https=) |
| AU (1) | AU2005309776B2 (https=) |
| CA (1) | CA2588713A1 (https=) |
| ES (1) | ES2380632T3 (https=) |
| IL (1) | IL183373A0 (https=) |
| MX (1) | MX2007006258A (https=) |
| NO (1) | NO20073170L (https=) |
| NZ (1) | NZ555565A (https=) |
| RU (1) | RU2412936C2 (https=) |
| WO (1) | WO2006057961A1 (https=) |
| ZA (1) | ZA200704913B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20040728A1 (es) | 2002-06-28 | 2004-10-23 | Vertex Pharma | Inhibidores de caspasa |
| TW200500343A (en) | 2002-12-20 | 2005-01-01 | Vertex Pharma | Caspase inhibitors and uses thereof |
| PE20050159A1 (es) | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
| MXPA06013256A (es) * | 2004-05-15 | 2007-02-08 | Vertex Pharma | Tratamiento de crisis convulsivas utilizando inhibidores ice. |
| ES2524922T3 (es) | 2005-05-10 | 2014-12-15 | Intermune, Inc. | Derivados de piridona para modular el sistema de proteína cinasa activada por estrés |
| CA2726588C (en) | 2008-06-03 | 2019-04-16 | Karl Kossen | Compounds and methods for treating inflammatory and fibrotic disorders |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
| RU2630677C2 (ru) | 2011-12-21 | 2017-09-12 | Оно Фармасьютикал Ко., Лтд. | Соединения |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| MX382781B (es) | 2014-04-02 | 2025-03-13 | Intermune Inc | Piridinonas anti-fibroticas. |
| US11447497B2 (en) | 2018-06-29 | 2022-09-20 | Histogen, Inc. | (S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating cardiovascular diseases |
| WO2023215559A1 (en) * | 2022-05-05 | 2023-11-09 | Aria Pharmaceuticals, Inc. | Compounds, compositions, and methods |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159196A (zh) * | 1994-06-17 | 1997-09-10 | 沃泰克斯药物股份有限公司 | 白介素-1β转化酶抑制剂 |
| CN1420872A (zh) * | 1999-12-08 | 2003-05-28 | 沃泰克斯药物股份有限公司 | 天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9207145D0 (en) | 1991-04-18 | 1992-05-13 | Ici Plc | Heterocyclic amides |
| CN1118458C (zh) | 1994-03-31 | 2003-08-20 | 弗特克斯药品有限公司 | 作为白细胞介素抑制剂的嘧啶基衍生物 |
| US5756466A (en) | 1994-06-17 | 1998-05-26 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
| US5847135A (en) * | 1994-06-17 | 1998-12-08 | Vertex Pharmaceuticals, Incorporated | Inhibitors of interleukin-1β converting enzyme |
| US5948785A (en) | 1995-04-27 | 1999-09-07 | The Green Cross Corporation | Heterocyclic amide compounds and pharmaceutical use of the same |
| WO1998016502A1 (en) | 1996-10-11 | 1998-04-23 | Warner-Lambert Company | ASPARTATE ESTER INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME |
| US6184244B1 (en) | 1996-12-16 | 2001-02-06 | Idun Pharmaceuticals, Inc. | C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| US6197750B1 (en) | 1998-07-02 | 2001-03-06 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
| US6242422B1 (en) * | 1998-10-22 | 2001-06-05 | Idun Pharmacueticals, Inc. | (Substituted)Acyl dipeptidyl inhibitors of the ice/ced-3 family of cysteine proteases |
| CN1176941C (zh) | 1999-04-09 | 2004-11-24 | 西托维亚公司 | Caspase抑制剂及其应用 |
| US6878743B2 (en) * | 2001-09-18 | 2005-04-12 | Sunesis Pharmaceuticals, Inc. | Small molecule inhibitors of caspases |
| US7960398B2 (en) * | 2002-04-19 | 2011-06-14 | Vertex Pharmaceuticals Incorporated | Regulation of TNF-alpha |
| PE20040728A1 (es) * | 2002-06-28 | 2004-10-23 | Vertex Pharma | Inhibidores de caspasa |
| TW200500343A (en) * | 2002-12-20 | 2005-01-01 | Vertex Pharma | Caspase inhibitors and uses thereof |
| PE20050159A1 (es) * | 2003-05-27 | 2005-04-19 | Vertex Pharma | Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa |
| KR20080038369A (ko) * | 2005-07-28 | 2008-05-06 | 버텍스 파마슈티칼스 인코포레이티드 | 카스파제 억제제 프로드럭 |
-
2005
- 2005-11-21 AT AT05825102T patent/ATE543803T1/de active
- 2005-11-21 CN CN2005800463680A patent/CN101098855B/zh not_active Expired - Fee Related
- 2005-11-21 EP EP05825102A patent/EP1833794B1/en not_active Expired - Lifetime
- 2005-11-21 US US11/284,366 patent/US8362043B2/en not_active Expired - Fee Related
- 2005-11-21 ES ES05825102T patent/ES2380632T3/es not_active Expired - Lifetime
- 2005-11-21 CA CA002588713A patent/CA2588713A1/en not_active Abandoned
- 2005-11-21 KR KR1020077014376A patent/KR20070086610A/ko not_active Ceased
- 2005-11-21 RU RU2007123615/04A patent/RU2412936C2/ru not_active IP Right Cessation
- 2005-11-21 NZ NZ555565A patent/NZ555565A/en not_active IP Right Cessation
- 2005-11-21 MX MX2007006258A patent/MX2007006258A/es not_active Application Discontinuation
- 2005-11-21 JP JP2007543346A patent/JP5055129B2/ja not_active Expired - Fee Related
- 2005-11-21 WO PCT/US2005/042139 patent/WO2006057961A1/en not_active Ceased
- 2005-11-21 AU AU2005309776A patent/AU2005309776B2/en not_active Ceased
- 2005-11-21 ZA ZA200704913A patent/ZA200704913B/xx unknown
-
2007
- 2007-05-24 IL IL183373A patent/IL183373A0/en unknown
- 2007-06-22 NO NO20073170A patent/NO20073170L/no not_active Application Discontinuation
-
2008
- 2008-10-30 JP JP2008280573A patent/JP2009108067A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159196A (zh) * | 1994-06-17 | 1997-09-10 | 沃泰克斯药物股份有限公司 | 白介素-1β转化酶抑制剂 |
| CN1420872A (zh) * | 1999-12-08 | 2003-05-28 | 沃泰克斯药物股份有限公司 | 天冬氨酸特异性半胱氨酸蛋白酶抑制剂及其用途 |
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| Title |
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| Graeme Semple et al..Pyridone-based peptidomimetic inhibitors of interleukin-1β-converting enzyme(ICE).Bioorganic & medicinal chemistry letters7 10.1997,7(10),1337-1342. |
| Graeme Semple et al..Pyridone-based peptidomimetic inhibitors of interleukin-1β-converting enzyme(ICE).Bioorganic & medicinal chemistry letters7 10.1997,7(10),1337-1342. * |
| Peter S. Dragovich et al..Structure-based design, synthesis, and biological evaluationof irreversible human rhinovirus 3C protease inhibitors.6.Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics..Journal of medicinal chemistry45 8.2002,45(8),1607-1623. |
| Peter S. Dragovich et al..Structure-based design, synthesis, and biological evaluationof irreversible human rhinovirus 3C protease inhibitors.6.Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics..Journal of medicinal chemistry45 8.2002,45(8),1607-1623. * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2009108067A (ja) | 2009-05-21 |
| EP1833794B1 (en) | 2012-02-01 |
| NO20073170L (no) | 2007-06-22 |
| JP2008521809A (ja) | 2008-06-26 |
| AU2005309776B2 (en) | 2011-12-22 |
| EP1833794A1 (en) | 2007-09-19 |
| RU2007123615A (ru) | 2008-12-27 |
| MX2007006258A (es) | 2007-07-20 |
| CA2588713A1 (en) | 2006-06-01 |
| KR20070086610A (ko) | 2007-08-27 |
| ZA200704913B (en) | 2008-09-25 |
| JP5055129B2 (ja) | 2012-10-24 |
| US20060160862A1 (en) | 2006-07-20 |
| ATE543803T1 (de) | 2012-02-15 |
| US8362043B2 (en) | 2013-01-29 |
| WO2006057961A1 (en) | 2006-06-01 |
| NZ555565A (en) | 2008-11-28 |
| ES2380632T3 (es) | 2012-05-17 |
| IL183373A0 (en) | 2007-09-20 |
| AU2005309776A1 (en) | 2006-06-01 |
| CN101098855A (zh) | 2008-01-02 |
| RU2412936C2 (ru) | 2011-02-27 |
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