CN101094896A - Novel uses of calcium hydroxide - Google Patents

Abstract

A heating ventilation and air conditioning ('HVAC') system having bacterial spore, viral, and fungal killing activity. The HVAC system components are at least partially coated with a biocidal composition having hydrated lime, soluble binder polymer mixture and humecatant are mixed in either an organic based- or water based- solvent system that is useful for coating HVAC system components.

Description

The new purposes of calcium hydroxide

Related application

The application requires to enjoy the U.S. Provisional Patent Application series number of submitting on November 4th, 2,004 60/624,991 right of priority, its title is " Novel Uses of CalciumHydroxide ", the invention people is Mallow W (late), Sigalos J.L., Glynson, B.C.G and Yeterian A.A., its all the elements with referring to mode incorporate this paper into.

About subsidize the statement of the right of the invention of making under the research in federal government

The present invention does not obtain the support that federal government subsidizes research.

Background

One aspect of the present invention is the chemistry thing coating of killing livestock, and it can prophylaxis of microbial be grown on the surface of such thing coating of killing livestock.More specifically, this thing coating of killing livestock contains calcium hydroxide, it gives this coating following dual performance: (i) can kill and be present in the microorganism on the matrix that the thing coating of killing livestock handled and (ii) can prevent such as the growth of future on the thing coating of killing livestock such as bacterium, fungi, algae and viruses.

Bacterium.Thinking that bacterium is a procaryotic branch, is to be generally single celled microorganism, does not have chlorophyll, breeds by simple division, has only the microscope of use just can see.Bacterium exists with 3 kinds of principal modes usually: spherical (coccus), shaft-like (bacillus), and spirrillum (spirobacteria).Some bacterium can be caused disease, as pneumonia and anthrax, other be that fermentation, fixed nitrogen etc. are necessary.

Bacterium under " normally " growth conditions is very great-hearted biology, and it can double once in per 20 minutes.Similarly, even at so-called " nutritional status ", bacterium also is great-hearted relatively biology, and it has the metabolism by porous adventitia sustainable utilization nutrition and water.When bacterium is during at nutritional status,, attack easily and kill them by their porous adventitia.When environment became unfavorable, some bacterium can enter " spore state ".It is billions of year that the spore state has been evolved, and spends the difficult moment to help bacterium, this by the genetic material packing is gone into hard and relatively not saturating film realize.In addition, in the spore state procedure, the metabolism of bacterium drops to imperceptible level, this make they very difficulty be killed.

Anthrax bacillus (Bacillus anthracis) is the first kind of bacterium that is proved to be the cause of disease.In 1877, Robert Koch made this biology pure culture ground growth, has confirmed its endosporic ability of formation, and by it is injected into animal, has produced experimental anthrax.The bacterium anthrax bacillus has nutritional status and spore state.Compare with other microbial spores, the anthrax bacillus spore is difficult to kill especially, and it has hard relatively and not saturating adventitia.Anthrax spores can germinate behind exsiccant dormant state non-activity many decades.By handling the product of infected animal, or by sucking from infected animal product () anthrax spores for example, wool, human can the infection by anthrax.By edible half-cooked meat from infected animal, the mankind also can be infected by gastrointestinal anthrax.Unfortunately, the terrorist understands purifying anthrax bacillus spore, and kills U.S. resident used as weapon.Most of existing methods of killing anthrax spores, for example irradiation and stifling with formaldehyde or chlorine dioxide may be effectively, but expensive, destruction is ecological, to resident's danger, and can cause long-term destruction to the environment that uses.The U.S. is faced with national crisis; need passively and expensively do not kill the new way of the spore (for example can cause the spore of the fusobacterium of tetanus, gangrene and sausage poisoning, and the spore of infectious mould and fungi) of anthrax spores and other poisonous microorganism.

At Estrela, Bammann, Estrela, Silva, and Pecora, Antimicrobial and Chemical Study of MTA, Portland Cement.Calcium Hydroxide Paste and Sealapex and Dycal, among Braz Dent J (2000) 11 (1) the 3-9155 N0103-6440, in agar diffusion test, several biocides have been tested at different bacterium bacterial strain (comprising Bacillus subtilus).The conclusion of this paper is " calcium hydroxide is better than [other biocide] to the antimicrobial acivity of all microorganisms of research ".The active resistance of anthrax bacillus spore combating microorganisms is not as the Bacillus subtilus spore.Thereby, infer that calcium hydroxide can usefully be used to kill anthrax spores.But the experiment of Estrela paper relates to and contains hydrospore.In principle, the calcium hydroxide of complete drying and the anthrax spores of complete drying can thoroughly mix, and exsiccant calcium hydroxide can not damage the exsiccant anthrax spores, because do not make hydroxide ion enter the approach of spore from calcium hydroxide.

Fungi.Fungi is a thallophytic gate (Mycophyta), comprises mould, reveals bacterium, mushroom, and rest fungus, and ustilago, they are parasite of living organism, or are food with the organism of death.Fungi does not have chlorophyll, true root, stem and leaf, and regenerates by spore.In some classification of organisms system, these biologies are included into independent field (fungi), do not regard plant as.

The present invention confirms, when fruit being placed the box that the thing coating of killing livestock described herein is housed, can weaken the growth of fungi on fruit.For example, used 2 boxes, it scribbles or is not coated with the thing coating of killing livestock.The result shows, after 1-7 days, is lined with the box of the paper that the thing of killing livestock handled in the bottom surface of box and side, when comparing with the box that the thing of not killing livestock is handled, shows the fungal growth of remarkable minimizing.

Virus.When the thing surface treated was killed livestock in contact, the present invention can kill many different viruses effectively.Usually, after killing livestock the thing surface treated, contact, can kill virus relatively than in the short time.The propagation of virus is controlled on the kill livestock surface of thing coating of use, is important in the economy in world today's scope.For example, H5N1 virus can not infect the mankind usually, catches from the danger of the H5N1 virus of bird less relatively.But, in 1997, in the process of the poultry bird flu that breaks out in Hong Kong, found H5N1 virus from fowl to anthrochorous first case.This virus has caused the serious respiratory illness of 18 people, wherein 6 people's death.After this, H5N1 occurred and infected other human case, had the high mortality relevant with avian viruses.The case of H5N1 infected person has taken place in Thailand, Vietnam, Cambodia, Turkey and Europe recently.The more important thing is that the mortality ratio of the case of these reports is about 50%.The occurrence cause of most of such cases is to contact infected poultry or polluted surface.This specific virus is sudden change adult-propagate to-people as yet.But, if the people of H5N1-to-people's variant, World Health Organization's prediction, worldwide popular takes place, and can be cost with several hundred million people's life.The present invention is verified, expose with contact the thing surface treated of killing livestock of the present invention after, can kill the virus in the classification identical with causing the H5N1 virus strain.

License to the United States Patent (USP) series number 6,280,509 (' 509 patent) of the title of Mallow August 28 calendar year 2001, described a kind of thing paint of killing livestock for " Biocidal CoatingCompositions and Method ".The thing film-forming composition of killing livestock of ' 509 patents is a kind ofly to contain white lime and the white lime inductive is solidified and the paint of the non-ionic type polyolefine latex of the resistance that is separated.Also disclose and prepare some such method for compositions, wherein under agitation white lime has been mixed mutually with non-ionic type polyolefine ester gum breast, and continued such stirring, finished basically, and the rheology of composition is stable up to the hydrolysis of ester.

License to the United States Patent (USP) series number 6 of the title of Mallow etc. May 15 calendar year 2001 for " Biocidal CoatingComposition ", 231,650 (' 650 patents), a kind of white lime paint or coating have been described, it is safe for public use, and can continue more for a long time than traditional whiting.Although do not wish to be bound by theory, the invention of ' 650 patents comprises specific tackiness agent, and it can stop carbonic acid gas to enter coating, prevent in carbonic acid gas and the coating itself or under lime reaction in the matrix.Tackiness agent is also compatible with white lime astoundingly, and after drying, makes that coating is lasting and adheres to.

Licensed to the United States Patent (USP) series number 6 of the title of Mallow etc. on March 28th, 2000 for " Biocidal CoatingComposition ", 042,638 (' 638 patents), the permanent biocidal activity of the white lime in paint or the coating has been described, wherein in paint or coating, use the tackiness agent of q.s to stop carbonic acid gas and white lime reaction, because the amount of white lime in described coating still is created on the lasting and adherent coating in dry back simultaneously, and can be not crisp excessively.

What submitted on June 1st, 2004 is contriver, the title U.S. Patent application 10/476 for " Stabilized Biocidal Coating Composition and Method " with Mallow etc., 732 (" ' 732 applications "), a kind of thing film-forming composition of killing livestock has been described, preferred paint, it comprises white lime, alkaline potassium salt and the white lime inductive solidified and the non-ionic type polyolefine latex of the resistance that is separated.Some method for compositions of preparation is also disclosed in ' 732 applications, wherein under agitation mix white lime and non-ionic type polyolefine ester gum breast, and continue such stirring, finish basically up to the hydrolysis of ester, and the rheology of composition is stable, and gets rid of the agglomerative generation.

A kind of composition of calcium hydroxide as chemical coating used in invention described herein, described coating can be used for coated surfaces (building walls for example, instrument, container, desk, Deng), maybe can mix clothes (gloves for example, apron, health clothes, Deng), it is killing bacteria, fungi, algae and virus for a long time.

The invention summary

Calcium hydroxide coating of the present invention provide from aseptic, antisepsis and sterilization, from the disinfectant surface, it can long-time keep this ability, and prophylaxis of microbial is bred on its surface and grown.It can reduce anthrax, tubercule bacillus, staphylococcus and similar infectious pathogen effectively.Need have passive, not expensive, the safe system of this effect for a long time, and not be met.

One aspect of the present invention relates to heating and ventilation and air-conditioning (" HVAC ") system, and it has the activity of killing bacteria spore, virus, algae and fungi.The HVAC system component scribbles biocidal composition at least in part, and the latter has white lime, soluble binding agent polymeric blends; And wetting agent.Aspect some, also comprise about 35% to about 40% latex.White lime, soluble binding agent polymeric blends and wetting agent be blended in be used for applying the HVAC system component based on organic or based on the solvent systems of water.The ratio of lime and soluble binding agent polymkeric substance is the 15.5%-25% (weight %) that about 1: 1 to about 1: 3 and wetting agent account for chemical coating.But this chemical coating permeate water, and not saturating basically carbonic acid gas.Those of ordinary skills know have several HVAC system components can apply the thing coating of killing livestock, and for example: the plumber does the whole inwall of system, return-air chamber; New air chamber mixing cassette air chamber; Coil chamber; Fan housing; Humid cabinet; Remove moist chamber; The spraying eradicator; Filter hood; Window shutter; HVAC air feed pipe and backwind tube; The air door adjustment sheet; Vapor pipe; Air door; Baffle plate; Strainer; Fan shield; With wall and floor board ventilation plant trave sheet.The HVAC system that handled with this thing coating of killing livestock has the ability of effective antagonism broad-spectrum micro-organisms, for example: bacterium, fungi, algae, virus, Bacillus subtilus, the latter is the substitute of anthrax spores; Pseudomonas aeruginosa; Streptococcus aureus; Salmonella choleraesuls; Intestinal bacteria; Streptococcus faccialis; Klebsiella Pneumoniae; Legionella pneumophilia; Mutual lattice chain lattice spore; Aspergillus; Branch spore (clodosporium) belongs to; Aureobasidium pullulans; Penicilliumfunicullatum; Stachybotras chartarum; Influenza A2 type; Rhinovirus; Rotavirus; Adenovirus 2 types; Respiratory syncytial virus; Hepatitis; Poliovirus I type; Herpes virus hominis I type; Parainfluenza virus III type, and H5N1 virus.

Second aspect of the present invention relates to the active clothes with killing bacteria spore, virus and fungi.These clothes scribble biocidal composition at least in part, and the latter has aforesaid white lime, soluble binding agent polymeric blends; And wetting agent.Some clothes that can mix the thing coating of killing livestock comprises apron, trousers, shirt, jacket, coat, robe, gloves, cap, shoes, boots, and socks.In one embodiment, clothes have first (outside that comprises clothes) and second (inboard that comprises clothes).These clothes have the activity of killing bacteria spore, virus and fungi, and it is effective to the biology of listing above at least.

The 3rd aspect of the present invention relates to the active ward article with killing bacteria spore, virus and fungi.These ward article scribble biocidal composition at least in part, and the latter has aforesaid white lime, soluble binding agent polymeric blends; And wetting agent.White lime, soluble binding agent polymeric blends and wetting agent be blended in be used for applying the ward article based on organic or based on the solvent systems of water, described article for example: building walls; Handle; Medicine equipment; Worktable; Computor-keyboard; The plastic cover of computor-keyboard; The secret curtain; Window-blind; Curtain; Hospital furniture; Or gatekeeper's equipment (janitorial equipment).

The invention discloses wonderful new purposes,, do not introduce so new purposes in the past although be starved of such kill livestock thing coating and method based on the thing coating of killing livestock of calcium hydroxide.Those of ordinary skills can understand the availability of the biocidal activity of the thing coating of killing livestock described herein.

Suppose astoundingly; suitably moisture as the contact area between carpospores and the calcium hydroxide; enter the medium of spore with the high alkalinity that calcium hydroxide is provided; and suitably be protected from the atmospheric air influence and avoided carbonating with protection calcium hydroxide; coating based on calcium hydroxide as herein described can kill substitute and other poisonous spore of anthrax spores effectively in practical astoundingly mode.

In order to understand several inventions disclosed herein, must understand that needn't kill all anthrax spores in this zone, (for example, the microorganism that comprises all other undesirable nutrition or spore state as a reference) suffers from anthrax to prevent this regional people.If a people has only accepted hundreds of or thousands of anthrax spores, this people unlikely can be ill, because this people's antibody forming system may be defeated the anthracia bacterium of so relative a small amount of.Usually, have only when people's antibody mediated immunity system is suffered a defeat by a large amount of anthracia bacteriums, this talent conference is ill and dead.Therefore, suppose that the passive and not expensive thing coating of killing livestock of the present invention (it can reduce anthrax in the specific environment or the number of other poisonous microorganism and spore) can significantly reduce the possibility of the ill or infected by microbes that is listed of people in this environment.

System of the present invention also can be used to kill the microorganism of the nutritional status that is in them, for some application, system of the present invention is sought help from, and at first sprays nutrition to anthrax spores, they are changed into nutritional status, thereby can kill them more completely, apace and definitely.And, the decontamination system that kills activated spore is also disclosed.But the spore that is difficult to kill can produce the most difficult problem.The application of the present invention in the complete decontamination in zone also disclosed.

It must be understood that for many coating as herein described, the useful consequence of expection " only " is the quantity that reduces poisonous spore in the specific environment, makes human body can defeat remaining spore.When all spores in the specific environment can not kill in passive and not expensive system of the present invention, suppose that it can reduce the number of the number of microorganism (for example anthrax spores) to safe enough.Thereby system of the present invention does not need 100% to eradicate spore astoundingly in its design.

A useful feature of kill livestock thing coating and processing of the present invention is, they can kill the microorganism of wide scope longer, innocuously, very effectively, and compares with the system system of killing livestock of competition, to the murder by poisoning of environment still less.

Up to now, confirm in test, when will be when the application of paints of calcium hydroxide be on surface treated, the microbial species below calcium hydroxide coating of the present invention can resist at least effectively: Pseudomonas aeruginosa: streptococcus aureus; Salmonella choleraesuls; Intestinal bacteria; Streptococcus faccialis; Klebsiella Pneumoniae; Legionella pneumophilia: mutual lattice chain lattice spore; Aspergillus; Cladosporium: aureobasidium pullulans: Penicilliumfunicullatum:Stachybotras chartarum; Influenza A2 type (Hong Kong); Rhinovirus; Rotavirus; Adenovirus 2 types; Respiratory syncytial virus; Hepatitis; Poliovirus I type; Herpes virus hominis I type; Parainfluenza virus III type.One skilled in the art will appreciate that these results are indicating the validity of resisting other microbial species.

Coating based on calcium hydroxide of the present invention kills the test microorganism of contact, and suppresses to contact the microbial growth of surface treated and regrow.They are applied to based on after on the coating surface of calcium hydroxide, and the time of killing these microbial species is 5-15 minute, and this depends on the kind of microorganism.These spores are applied to solvent-based coating based on calcium hydroxide, need to expose 30-60 minute and thoroughly destroy described biology, this depends on the kind of viral and bacterium.

The accompanying drawing summary

Below accompanying drawing constitute the part of this specification sheets, and included and be used for real some aspect of the present invention of further exhibition.With reference to the one or more accompanying drawing, and this paper is to the detailed description of particular, and the present invention may be better understood.

Fig. 1 and Figure 1A have shown the binding mode of inferring of the so-called BNA (Bi-neutralizing agent) that is used to kill based on the microorganism on the coating surface of calcium hydroxide.Under first situation, from the teeth outwards with the coating of BNA system.This BNA system uses the lime and the tackiness agent of calcium hydroxide, carbonating, generates film semipermeable especially, selective permeation.This film (core of BNA binding mode) allows water vapour and microorganism to penetrate film, and reaches calcium hydroxide, therefore is killed.Simultaneously, this film can stop through carbonic acid gas, and protection calcium hydroxide is avoided carbonating.The result is that biocidal surface is fatal to microorganism, but harmless to humans and animals.

Fig. 2 has shown BNA laboratory results table, and row are the descriptions to special test, and row are corresponding test-results.

Fig. 3 has shown at the box that scribbles BNA coating with without any fruit in the contrast box of coating and the fungal growth on the plant.This test comprises 2 boxes, and one is lined with the paper that BNA handled on the bottom surface of box and side.The box of handling to BNA covers a transparent cover of not handling with BNA.The contrast box is not lined with the paper that BNA handled, and covers a transparent cover of not handling with BNA yet.Figure A has shown fruit in the box that is lined with BNA after 3 days and plant (for example orange, banana, apple, potato and plum); Figure B does not have fruit in the box of BNA lining and plant (for example orange, banana, potato, apple and plum) when having shown 3 days; Figure C has shown fruit in the box that is lined with BNA after 7 days and plant (for example orange, banana, apple, potato and plum); Figure D does not have fruit in the box of BNA lining and plant (for example orange, banana, apple, potato and plum) when having shown 7 days.The conclusion of this research is, compare with plant (they show fruit and plant degradation normal and expection speed) with the fruit of the box that does not have the BNA lining, all fruit in being lined with the box of BNA and plant show the ability of its virgin state of visibly different prolongation, show the sign of the Natural Degradation of much less.Predict, do not compare with there being the BNA protection, the organic product under the BNA protection has the much longer shelf lives, and it can keep freshness to surpass 2 times of times.

Fig. 4 shown in room temperature after 13 days, BNA handled be untreated stachybotrys atra (Stachybotras Atra) in the flat board of contrast.Difference is conspicuous.On flat board is untreated in contrast, have microorganism growth widely, and the flat board that BNA handled does not show fungal growth.

Fig. 5 has shown table 1.By being exposed to the test article that scribbles BNA and Control paint, inactivated poliovirus 1 type.Figure A has shown the result who uses the BNA water-based paint; Figure B has shown the result who uses BNA solvent based paint; Figure C has shown the result who uses non-BNA Control paint.

Fig. 6 has shown table 2.By being exposed to the test article that scribbles BNA and Control paint, deactivation human herpesvirus 1 type.Figure A has shown the result who uses the BNA water-based paint; Figure B has shown the result who uses BNA solvent based paint; Figure C has shown the result who uses non-BNA Control paint.

Fig. 7 has shown table 3.By being exposed to the test article that scribbles BNA and Control paint, the deactivation haemadsorption virus 1.Figure A has shown the result who uses the BNA water-based paint; Figure B has shown the result who uses BNA solvent based paint; Figure C has shown the result who uses non-BNA Control paint.

Fig. 8 has described the different tests of carrying out, and shows that the article that scribble BNA can eliminate Salmonellas and pseudomonas; Staphylococcus, streptococcus aureus and Pseudomonas aeruginosa and the virus of selecting.

Fig. 9 has shown the validity of the anti-many kinds of microorganisms of object that BNA handled.

Figure 10 has shown the explanation of calcium hydroxide situation.

Detailed description of the preferred embodiments

Although invention disclosed herein relates to from the zone or eliminate on the surface or eliminate various microorganisms basically, comprise poisonous spore and nutritional type bacterium, the present invention is more specifically described with reference to anthrax spores.

Term " calcium hydroxide " is used in reference to calcium hydroxide-Ca (OH) in this article ₂-a kind of clear crystal or white powder prepares by calcium oxide (lime) and water are reacted.Calcium hydroxide is used for tens of kinds of products by the FDA approval, and is used for medicine, additive, milk preparation, sugar, gelatin, baked goods and dentistry industry.

Term " liming " is used in reference to the aqueous solution of calcium hydroxide in this article, is used for the treatment of acid burn and is used as antacid.Calcium hydroxide is also referred to as slaked lime or white lime, is used as biocide (especially before microbiotic) in hospital over thousands of years.Its antimicrobial efficacy is derived from pH or basicity is increased to and the inconsistent level of the life of microorganism.

Term " Caliwel ' s " is also referred to as Bi-neutralizing agent (Bi-Neutralizing agent) (" BNA "), and it is safe and nontoxic to humans and animals.Usually, calcium hydroxide can be lost effect in several days, because it can decompose rapidly after being exposed to air.Although do not wish to be bound by theory, preventing carbonic acid gas (" CO ₂In the microencapsulation preparation that the calcium hydroxide that ") causes decomposes usually, BNA can work by the kill microorganisms ability that strengthens calcium hydroxide.The BNA encapsulation process allows calcium hydroxide to keep its alkalization ability, protects it to avoid decomposing simultaneously, thereby makes its anti-degraded and keep the effective antimicrobial surface several years.

The thing coating of killing livestock

One aspect of the present invention comprises the title that licenses to improved May 15 calendar year 2001 such as Mallow etc. the described thing coating of killing livestock of U.S. Patent number 6,231,650 (' 650 patent) for " Biocidal Coating Composition ".' 650 patents have been described a kind of white lime paint or coating, and it can kill microorganisms, and are safe for public use.The described coating of ' 650 patents can continue more for a long time than traditional whiting.Although do not wish to be bound by theory, the invention of ' 650 patents comprises specific tackiness agent, and it can stop carbonic acid gas to enter coating, prevent in carbonic acid gas and the coating itself or following matrix in lime reaction.Tackiness agent is also compatible with white lime astoundingly, and makes coating lasting and adhere to after drying.

The thing coating of killing livestock of the present invention is nontoxic, and after being exposed to 100% carbonic acid gas 1 month (its can be in 1-2 days the white lime in the conventional calcicoater of carbonating) fully, can keep the basicity of kill microorganisms effectively.As used herein, term " was exposed to carbonic acid gas 1 month " and is used in reference to and is exposed to 100% carbonic acid gas 2 days.In fact, the thing coating of killing livestock can be kept their indefinite time period of biocidal activity, even when in 100% carbonic acid gas, wearing out.

The concrete composition of killing livestock in the thing coating is tackiness agent and lime.The thing coating of killing livestock is preferably included in the following material in the appropriate solvent: white lime; Tackiness agent; Wetting agent; And weighting agent.Preferably, this coating also comprises pigment, tensio-active agent, and defoamer.In some embodiment, may wish to add softening agent.Tackiness agent of the present invention can show unexpected carbonic acid gas barrier properties, UV resistance and the biocidal activity that prolongs.Other component comprises the component of solidifying and being separated as the described minimizing of ' 732 applications.Coating of the present invention is safe, is easy to preparation, and contains lower cost materials, makes that this coating is easy to be afforded by medical science, agricultural, industry and domestic consumer etc.Some preferred adhesive or component comprise: PolyOx.TM. (polyoxyethylene, Union Carbide); Hydroxy ethyl cellulose (HEC), available from Hercules, Inc.; Vltra tears (HPMC), available from Hercules, Inc.; Ethyl hydroxy ethyl cellulose (EHEC), available from Hercules, Inc.; Carboxymethyl hydroxy ethyl cellulose (CMHEC), available from Hercules, Inc.; Carboxymethyl cellulose (CMC), from Air-Products, Castament is from DeGussa available from Dow Chemical[Sufynol, and Zonyl is from Dupont, special level lime is from Mississippi Lime, Kronos is from Cronos, and Tylac is from Dow Richhold, and Nopco is from Cognes, Foam Blast is from Lubrizol, Culminal is from Hercules, tripropylene glycol, Nytal is from Vanderbuld].

The solvent of coating material and tackiness agent or carrier can be aqueous or organic.Choice of Solvent depends on the condition that the article of coating can run into.For example, if coating will be exposed to outdoor conditions, if or coating will be exposed to repeated washing, then the tackiness agent based on organic solvent is preferred.Be used to prepare the amount of the solvent or the carrier of coating, depend on the using method of expection.Preferably, but should use solvent or carrier with the amount that is enough to make coating to become dispersing fluid.

The tackiness agent of biocidal composition should have the film properties of carbonic acid gas barrier, but the effect of unable to get up water vapor barrier.Should stop the reaction of carbonic acid gas and white lime to form lime carbonate basically.Water vapour should penetrate film, to keep the water content that is enough to reach following purpose: draw in and packing microorganism and other biological pollutant basically (1), (2) hydroxyl ion in the lime is maintained Ionized, overbasic state, so that lime can kill biological pollutant or otherwise make them harmless.

Those of ordinary skills will appreciate that some tackiness agent is inconsistent with the white lime chemistry, should not be used for the present invention.Usually, these inconsistent tackiness agents comprise most of latex adhesives, the latex of pH sensitivity especially, and they almost cause solidifying and being separated with after lime mixes immediately.Other inconsistent tackiness agent is water miscible binder for film formation, for example some polyvalent alcohol, polynary ester, albumen and starch deutero-carbohydrate.Many such tackiness agents are unsettled in the hydrophite ash system, can produce viscosity usually along with time steady change and frequent even solidified mixture.Suitable binder should provide the chemical compatibility with white lime, the adhesion of hope and coating performance and the barrier properties that requires.Preferred adhesive is to be selected from following derivatived cellulose: alkyl derivative, hydroxy derivatives, and carboxy derivatives.Most preferred tackiness agent is ethyl cellulose and Vltra tears.

The ratio of tackiness agent and lime is a feature of this coating in the coating.If the lime ratio improves, coating can have higher biocidal activity, but can be more crisp.If the tackiness agent ratio improves, the fragility of coating can be lower, but the biocidal activity of coating may reduce.Provided water base below and screening formulation organic radical coating.The type of solvent no matter, the amount of the tackiness agent of use should be enough to prevent the carbonating of lime, and the biocidal activity of keeping coating preferably is enough to continue 4 years or tackiness agent more of a specified duration at least about " being exposed to carbonic acid gas 1 month ".Typically, lime: the tackiness agent proportional range is about 1: 1 to about 3: 1, preferred about 1.5: 1.

Water-based paint: be applicable to that water-soluble binder of the present invention includes but not limited to, the polymkeric substance of the cellulose-derived of water-soluble poly alkylene oxide and hydroxylated or carboxylation, include but not limited to the salt and the cellulosic carboxyalkyl-derivative of cellulosic acid, carboxyethyl cellulose for example, carboxymethyl cellulose and carboxyl hydroxylated cellulose.The polymkeric substance of preferred cellulose-derived is a Vltra tears, and most preferably Grade E5 can obtain from Dow Chemical Co..Preferred polyalkylene oxides is Polyox.RTM.Grade N-80, can obtain from Union Carbide.Water-soluble polyethylene glycol, for example the CARBOWAX.TM. kind can obtain from Dow ChemicalCo. and Union Carbide, also should be used as water-soluble binder of the present invention; But polyoxyethylene glycol is not a preferred adhesive.

Coating preferably contains wetting agent, so that water and steam is sucked coating, and the water content of coating is stabilized in the level of basicity that is enough to that biological pollutant drawn in lime and keeps effective kill microorganisms of white lime.The suitable wetting agent of water-based paint including but not limited to, water soluble glycols, for example glycerine, polyoxyethylene glycol and tripropylene glycol.The preferred wetting agent of water-based paint is a glycerine.

Preferably, coating should contain softening agent, to promote the elasticity and the toughness of processing and enhancing the finished product.Think polymer molecule in softening agent meeting " solvation " coating.The suitable manufacturing methods of water-based paint also can be used as wetting agent, including but not limited to, glycerine and polyvalent alcohol, for example polyoxyethylene glycol and its derivative.Preferred water-soluble plasticizer is a glycerine." properties-correcting agent " also refers to tensio-active agent, defoamer, and softening agent, and wetting agent, combined.

The example of preferred water-based paint is as follows:

Component	The weight part scope	(preferably)
			Tackiness agent	10-30	(20)
White lime	10-30	(30)
			Water	60-150	(100)
Tensio-active agent	0.5-2	(1)
			Titanium oxide	10-100	(50)
Lime carbonate	0-30	(0)
			Softening agent (that is glycols)	2-20	(10)
The hydrophilic thickening agent	0-2	(1)
			Pigment	(as required)
Lime: tackiness agent ratio	1: 1 to 3: 1	(1.5∶1)
			Weighting agent: tackiness agent ratio	3.5: 1 to 9.5: 1	(3.5∶1)

Organic radical coating.The suitable binder that dissolves in the organic solvent includes but not limited to that the polymkeric substance of cellulose-derived includes but not limited to: alkylcellulose; Ether of cellulose; Cellulose ester, for example cellulose acetate and cellulose butylate.The preferred adhesive that is used for organic solvent is an ethyl cellulose.Some organic soluble polyoxyethylene glycol also can be as the tackiness agent in the organic radical coating; But polyoxyethylene glycol is not preferred.

Organic solvent system should have controlled drying rate, to avoid contraction or crack.Organic radical coating preferably should comprise about 2-20 weight % wetting agent, preferably about 5-15 weight % wetting agent.Suitable wetting agent comprises organic soluble poly aklylene glycol.The preferred humectants of organic radical coating is a propylene glycol.

The suitable manufacturing methods of organic radical coating including but not limited to, non-volatile organic liquid and low melting point solid, phthalate for example, adipic acid ester, and sebate, Tritolyl Phosphate, Viscotrol C, etc.The preferred plasticizer of this organic radical coating is a propylene glycol, and it also can be used as wetting agent.

Preferred solvent based paint is as follows:

Component	The weight part scope	(preferably)
			Tackiness agent (ethyl cellulose)	10-30	(20)
White lime	10-30	(30)
			Dimethylbenzene	50-200	(100)
Toluene	25-100	(50)
			Ethanol	0-50	(5)
Solvent oil	0-50	(5)
			Titanium oxide	15-100	(50)
Lime carbonate	0-30	(5)
			Softening agent	0-10	(5)
Hydrophobic thickener	2-20	(10)
			Pigment	(as required)
Lime: tackiness agent ratio	1: 1 to 3: 1	(1.5∶1)
			Weighting agent: tackiness agent ratio	3.5: 1 to 11.5: 1	(3.5∶1)

Along with the adding of the pigment (tinting material) of non-oxide titanium or add pigment (tinting material) again outside titanium oxide, weighting agent is than regular meeting high-end in this scope.Usually, typically use very in a small amount the pigment (tinting material) of (the 2-5 weight % of total prescription) that the color harmony colourity that needs is provided.

Can use useful components in any solvent systems.Some component of coating can be used for water base or organic radical coating.For example, weighting agent is reflected in the above-mentioned preparation, and preferably adding is expanded coating and for coating provides immanent structure, shunk and peeling to reduce, and stay continuous coated after moisture evaporation.The suitable weighting agent that uses with any solvent systems including but not limited to, lime carbonate, barium sulfate, silicate, glass sphere, hollow microsphere, SiO 2 powder, clay, talcum powder, volcanic ash, flying dust, slag, titanium oxide etc.Preferred weighting agent is a lime carbonate.

If desired, can add pigment or opalizer, so that coating is opaque or add color to coating.Suitable pigment/the opalizer that uses with any such solvent systems including but not limited to, lime carbonate, titanium oxide, carbon black, chromic oxide, and ferric oxide.Preferred opalizer is a lime carbonate, and it also can play weighting agent; And titanium oxide, it also can play whitening agent.Pigment/opalizer preferably should account for about 5-10 weight part of coating.

Can also use the ionic and/or the nonionic surface active agent of wetting agent, stain remover or emulsifier type, to reduce surface tension and to increase coating wetting its efficient of composition in mixing process.Suitable tensio-active agent that uses with any such solvent systems and stain remover including but not limited to, alkyl and aryl sulfonic acid sodium (anionic), the alkylbenzene phenolic ether (non-ionic type) and the various cationoid reagent of polyoxyethylene glycol.Preferred surfactants is Dupanol ME, can obtain from Dupont, and Tergitol TMN and Tergitol 15S70, the two can obtain from Union Carbide, or Triton X-100, can be from Rohm﹠amp; Haas obtains.

If desired, also can add defoamer or defoaming agent, process with facility.The suitable defoamer that uses with any such solvent systems is including but not limited to, sulphonated oil, organophosphate, and silicone oil, dimethyl polysiloxane, etc.Preferred defoamer is the Foam Blast 383 from Lubrizoil, Nopco NXZ fro Cognes, Dow Corning defoamer DB-31, SG-10,1510US, 544 compounds, DBl 10A and similar defoamer, they can obtain from Dow Corning commercial.Most preferred defoamer is SG-10, can obtain from Dow Corning.

No matter water base still organic radical, it is thick that the thing coating of killing livestock preferably is applied to about 2-5mils, with the long-term biocidal activity of guaranteeing lime.But, can use thinner or thicker coating.

In paint industry, adopt sizable latitude to influence the paint or the coating of differing texture, color and gloss or unglazed outward appearance.Such practice can be applied to these basic recipes, and do not change they antimicrobial properties and their weather resistance aspect the carbonic acid gas resistance, condition is that they do not surmount the lime/tackiness agent ratio and the pigment/binder ratio of the key of expressing in declared range.The scope that provides in the preceding surface compositions allows such latitude in the practice of preferred paint, quality, color and utilisation technology.

Mix the independent protective coating of non-water-soluble adhesive.Exist some to worry, promptly the long-time tolerance of water-based paint or paint is not as organic radical coating because repeat to scrub, wiping etc.A kind of mode that prolongs the life-span of any basically white lime coating (comprising water-based paint) is, provides protective membrane to coating, and it comprises one of non-water-soluble or organic soluble tackiness agent of listing above.

Calcicoater under non-water-soluble adhesive in the independent protective membrane should be provides and tackiness agent is directly mixed the substantially the same protection of protection that produces in the calcicoater.Tackiness agent in the protective membrane should prevent the lime reaction in carbonic acid gas and the beneath coating, and allows moisture to penetrate coating.

In a preferred embodiment, protective membrane comprises the water insoluble cellulosic derived polymers of about 5-15 weight %, and the latter is dissolved in the suitable organic solvent of about 85-95 weight %, preferred volatile organic solvent.Protective membrane preferably sprays with mist or otherwise is deposited on the water-based paint, to guarantee abundant covering and the protection to coating.

Component below using has prepared and has contained the organic radical coating of ethyl cellulose as tackiness agent:

Component	The weight part scope
		Ethyl cellulose	About 5-20 (ETHOCEL.TM. obtains from Dow Chemical)
Toluene	About 30
		Dimethylbenzene	About 50
Ethanol	About 20
		Calcium hydroxide	About 50
Titanium oxide	About 50
		Propylene glycol	About 5-15

Compositional range below using has prepared and has contained different tackiness agents [PolyOx.TM. (polyoxyethylene, Union Carbide) for example; Hydroxy ethyl cellulose (HEC), available from Hercules, Inc.; Vltra tears (HPMC), available from Hercules, Inc.; Ethyl hydroxy ethyl cellulose (EHEC), available from Hercules, Inc.; Carboxymethyl hydroxy ethyl cellulose (CMHEC), available from Hercules, Inc.; Carboxymethyl cellulose (CMC) is available from Dow Chemical], and other preferred water-based paint of different properties-correcting agent [tensio-active agent for example, defoamer, softening agent, and wetting agent, combined]:

Component	The weight part scope
		Tackiness agent
		5,10 and 15
	Water		100
Calcium hydroxide		10-50
	Lime carbonate		50-150
Titanium oxide		0-15
	Properties-correcting agent		5-15

Applying coating to different substrates, is comprised concrete, the plaster of Paris, aluminium, stainless steel, plastics etc. are to the thickness of about 2-5mil, typically about 3mil.Coating shows good adhesion.

Embodiment

The following examples are used for further explaining the present invention and implementation thereof.But, should be appreciated that the detail that provides is in an embodiment only chosen and be used for task of explanation, not should be understood to limit the present invention.Thereby those of ordinary skills will appreciate that, can make many improvement to the present invention, and not break away from the spirit and scope of the present invention.

Embodiment 1

Add wetting agent

As top and ' 509 patents, ' 650 patents, ' 638 patents and ' 732 applications described in, if its high alkalinity can be communicated to bacterium, mould, fungi, etc., then calcium hydroxide has biocidal activity.For effective coating that can reach this purpose lastingly is provided, most of coating as herein described: (1) allows to be communicated to or the alkalescence effect of hydroxide ion is communicated to biology on the coating surface through water from the hydroxide ion of the calcium hydroxide in the coating, (2) prevention Atmospheric Carbon Dioxide contact calcium hydroxide, this contact meeting changes into useless lime carbonate by carbonating with calcium hydroxide.That is to say, for persistent anti-microbial effect is provided, the invention provides calcium hydroxide, it can carry out exchanging through water of essence with coating surface, but does not exchange with the gas that coating surface carries out essence.Although glycerine is used for this purpose, can usefully use the cellulose paint of non-glycerine with similar effect.

Protective layer in the coating of the present invention, Mierocrystalline cellulose as herein described typically can prolong life-span of the calcium hydroxide in the calcium hydroxide coating of the present invention, and is much longer during than calcium hydroxide contact environment carbonic acid gas, at least 30 days.Based on testing data, think that the present invention can make based on the calcium hydroxide in the coating formulation of latex and solvent and kept activity at least 1 year, even above 6 years.Carbonic acid gas protective layer except for, because the carbonating of atmospheric carbon dioxide, calcium hydroxide around usually can degraded rapidly in several weeks in the air, thereby makes its lose its biocidal properties.

The microorganism that is in nutritional status contains suff water usually, and has the adventitia of fully saturating property, is communicated in the biology with the basicity with calcium hydroxide.If will be in the atom contact calcium hydroxide of nutritional status, they can be killed.But the adventitia that spore does not contain suff water usually or has a fully saturating property is to pass on the basicity of calcium hydroxide in the spore.Extra moisture source must be offered the surface in contact of calcium hydroxide and spore, make the calcium hydroxide killing spores.

Although this paper has discussed the conversion of spore to their nutritional status, the present invention also predicts, and only making the spore fluid cooperation is a step of killing them.Need hydration to allow the basicity of calcium hydroxide to have killing effect ground and pass on spore.Although spore is useful to the conversion of nutritional status,, realize that the present invention not necessarily must need to do like this because be in easier the killing of microorganism of their nutritional status.Realize that invention disclosed herein often only needs the simple hydration of spore, rather than change into its nutritional status.The present invention has utilized this discovery in disclosed coating, composition and method.In the discussion of this paper, the moisture of mentioning that provides changes into nutritional status with target microorganism, comprises the intermediate steps of hydration microbial spore, and can suitably end up with this step under the situation.

As described herein, according to their desired use, the thing coating of killing livestock of the present invention can be various compositions.For wall paint, the thing coating of killing livestock typically comprises polymeric liquid and becomes membrane matrix.In some composition, coating comprise in a small amount the hydrophilic thickening agent or wetting agent as frostproofer.In the present invention, kill the increase that the expected results of anthrax spores has inspired moistening dosage astoundingly, be used to supply with and pass on the into required moisture of spore the effect of calcium hydroxide basicity.The umber of wetting agent in neoteric coating can extend to above 15% from about 5% coating.The most useful scope that is used for killing effectively the coating wetting agent of exsiccant anthrax spores be the coating volume surpass 15% to about 25%.That more a spot of wetting agent can provide is lower, but still useful and still unexpected spore kills ability.Coating can keep spore to kill ability at least 30 days, preferably at least 1 year.

The type and the quantity of the wetting agent of selecting, be enough to from absorption of air moisture, and be concentrated in the thing coating of killing livestock, or keep suff water from the initial application of coating, so when thing coating is killed livestock in spore (for example anthrax spores) contact, by the moisture that wetting agent provides, the basicity of calcium hydroxide can be passed on into spore in the coating.More specifically, spore kills ability if desired, and calcium hydroxide need be transported to the moisture of q.s the required enough types of point of contact between spore and the calcium hydroxide and the wetting agent of q.s to the killing effect of spore.By routine test, can determine for any given coating the concrete significant quantity of wetting agent.And this paper describes the invention combination, discloses the atomizing and humidifier or the washing form etc. that moisturize, and they have effect to the desired amount of wetting agent separately.

The preferred wetting agent of calcium hydroxide coating of the present invention is 15 weight % glycerine.Other useful wetting agent is: vegetables oil, ammonium chloride, calcium chloride, sodium sulfate, Tai-Ace S 150, sodium-acetate, and salt hydrate.The hydrocarbon tackiness agent of wetting agent such as glycerine and ethylene glycol and calcium hydroxide coating of the present invention is incompatible.The suitable wetting agent of organic radical coating comprises organic soluble poly aklylene glycol, and other.Propylene glycol and polypropylene glycol are useful wetting agents, but not strong as glycerine.The design of wetting agent itself is well-known, especially for the those of ordinary skill of cosmetic industry.Cosmetic industry often uses wetting agent to keep high-caliber moisture at skin surface.But the purposes of the killing effect of the promotion calcium hydroxide of wetting agent is wonderful.

Those skilled in the art can understand, use the application's instruction, except the latex carrier, also can will be used to set up antimicrobial surface based on the paint of volatile organic solvent or based on the paint of water soluble cellulose.And the personnel with this area and periodictable knowledge can understand from present disclosure, can use other basicity source instead of hydrogen calcium oxide, generate the expectation source of the kill microorganisms basicity of the present invention's needs.

In some thing coating of killing livestock as herein described, do not need the wetting agent of additional quantity.For example, the gloves that meat Package person or food-processing person use usually can be from meat, product or the food accumulation suff water of handling, so do not need wetting agent, the basicity of calcium hydroxide just can be passed on into spore, has killing effect.The present invention has utilized this discovery.Such thing coating of killing livestock will be discussed below.

In addition, in some environment, suff water can be drawn onto from air in the coating, be retained in the coating from smearing at first of coating, or be present in the air of the outside surface that is applied to coating, so need not special wetting agent, the basicity of calcium hydroxide just can be passed on into spore.Such thing coating of killing livestock will be discussed below.

Embodiment 2

Horizontal surface or working-surface

' 509 patents, ' 650 patents, ' calcium hydroxide/Mierocrystalline cellulose/latex paint of 638 patents and ' 732 application, can improve as teaching herein, and place on the horizontal surface of mailing chamber, post office etc., to kill anthrax spores.This is the new and wonderful purposes of the thing coating of killing livestock of the present invention.' 509 patents, ' 650 patents, ' prescription of the thing paint of killing livestock in the application of 638 patents and ' 732, typically be used for wall and vertical surface, and be not to be designed for especially to kill anthrax spores.At first, as described above, for being designed to especially, coating of the present invention can kill anthrax spores most effectively, the wetting agent of appropriate amount is added the thing coating of killing livestock, to supply with required moisture.Secondly, in order to increase the weather resistance of horizontal surface or working-surface, the latex content of the thing of killing livestock paint or coating preferably from ' 509 patents, ' 650 patents, ' 638 patents and ' 732 application about 25% increase to the interior amount of about 40% scope of about 35%-.

Owing to carry out work on it, working-surface can flood the skin of grease, dust, dust and dirt etc. along with the time.The thing coating of killing livestock that contains extra latex and additional hydrogen calcium oxide of the present invention is designed to competent and rinsable, and at least 30 days and preferably can not lose the validity of real mass at least 1 year, as long as coating contacts continuous water flushing.And, when the surface is dirty, can kill the fluid wash surface of performance and general antimicrobial properties with the anthrax that contains extra calcium hydroxide and can recover the surface effectively to a certain extent.

Suppose, if moisture otherwise is provided as required, for example spraying or with the wet regular wiping of rag, or in the presence of high humidity, then can reduce or omit extra wetting agent.

Can understand as those skilled in the art, the resin and the latex of additional type and amount can be added paint, make it enough hard and durable, so that the horizontal operation surface to be provided, still comprise simultaneously the calcium hydroxide that is communicated with the coating outside surface of q.s, provide the basicity of q.s to come killing spores on the outer surface.

Disclosed antimicrobial invention is applicable to any surface, can be outside surface level, vertical, machine or internal surface etc.The internal surface and the outside surface of machine (for example the mail sorting of post office and process instrumentation and other movement of objects equipment) can have the superincumbent coating of the present invention of application.Any coating as herein described and handle can be combined with static is used to attract the purpose with kill microorganisms.Increase additional surface can for such instrument, and fill static, be used to attract and kill the purpose of the spore on other object that is attached to mail or processing.Can add instrument, it intentionally makes object stand: to the gentle friction in the surface of coating, (2) vibrate on the surface of coating (1), and (3) make air move to the surface of coating, or (4) are to the static of the attracted by surfaces microorganism of coating.Can this instrument of routine test, to determine whether to have caught target microorganism.Some object, for example the object of the key of computor-keyboard, handle, ground surface, phone, toilet seat and other high rate of utilization or scraping can be included in and mix material of the present invention in the object self.Special ground cushion or carpet with coating dipping of the present invention can be used for high-risk zone, catch and kill microorganisms.These objects can static electrification, attracts microorganism and kills them.

Embodiment 3

The container of killing livestock

Bacterium and fungi.Although do not wish to be bound by theory, in Fig. 1, shown the binding mode of inferring of the lip-deep bacterium that kills calcium hydroxide coating.At first kind of state, with the thing applying coating surface of killing livestock that is called the BNA system.The BNA system uses the lime and the BNA tackiness agent of calcium hydroxide, carbonating.Usually, BNA system and water vapour and carbonic acid gas interact, and generate the surface harmless to humans and animals.Bacterium, fungi, virus and algae reproduction unit can not successfully grow on the BNA surface treated surely.As a result, the BNA system can destroy all test microbes of contact, even virus.By removing the surface of infecting with BNA, it is more healthy to the occupant that the space can become.

The table that in Fig. 2, has shown the thing coating BNA laboratory results of killing livestock.The table of Fig. 2 contains description and the row corresponding test-results of row about special test.

As shown, Fig. 3 has shown at the box that scribbles BNA coating with without any fruit in the contrast box of coating and the fungal growth on the plant.This test comprises 2 boxes, and one is lined with the paper that BNA handled on the bottom surface of box and side.The box of handling to BNA covers a transparent cover of not handling with BNA.The contrast box is not lined with the paper that BNA handled, and covers a transparent cover of not handling with BNA yet.Figure A has shown fruit in the box that is lined with BNA after 3 days and plant (for example orange, banana, apple, potato and plum); Figure B does not have fruit in the box of BNA lining and plant (for example orange, banana, potato, apple and plum) when having shown 3 days; Figure C has shown fruit in the box that is lined with BNA after 7 days and plant (for example orange, banana, apple, potato and plum); Figure D does not have fruit in the box of BNA lining and plant (for example orange, banana, apple, potato and plum) when having shown 7 days.The conclusion of this research is, compare with plant (they show fruit and plant degradation normal and expection speed) with the fruit of the box that does not have the BNA lining, all fruit in being lined with the box of BNA and plant show the ability of its virgin state of visibly different prolongation, show the sign of the Natural Degradation of much less.Predict, do not compare with there being the BNA protection, the organic product under the BNA protection has the much longer shelf lives, and it can keep freshness to surpass 2 times of times.

Embodiment 4

The thing gloves of killing livestock.

The staff in die Postangestellter, medical science staff and packaging unit, food processing plant, grocery store etc. can benefit from the nontoxic antimicrobial gloves of cheapness.Die Postangestellter, doctor, nurse, other healthworker etc. have used disposable latex glove.By flooding these gloves with enough calcium hydroxide according to the present invention, gloves can kill anthrax spores and have general antimicrobial acivity.Usually, as is known to persons skilled in the art, by the specific component of the various paint of deletion from the aforementioned thing latex paint prescription of killing livestock, for example pigment, weighting agent etc., and add softening agent, rubbery agent etc., can prepare the thing latex glove of killing livestock of the present invention.In one embodiment, if gloves are disposable gloves, i.e. expection has the life-span in the carbonating parameter, and the protective cover of setting up described anti-calcium hydroxide carbonating does not need Mierocrystalline cellulose (needing) in the long-acting thing paint of killing livestock.The disposable latex glove of the thing calcium hydroxide dipping of killing livestock like this can obtain from the gas tight container of working space, so that prevent carbonating before use.Pre-packing like this is that the disposable latex glove of medical field is common.The staff opens gas tight container, reaches out gloves, puts on one's gloves, and uses gloves in staff's process on duty, and abandons gloves when end on duty.The life-span of this gloves is enough short, makes carbonic acid gas in the surrounding environment can not have time enough calcium hydroxide enough in the gloves is changed into lime carbonate and greatly reduces the kill livestock thing validity of gloves in 12 hours periods.

This is opposite with the thing paint of killing livestock of the present invention, and the latter needs cellulose binder to protect calcium hydroxide to avoid the carbonic acid gas influence for a long time, surpasses 30 days at least, and preferably above 6 years.Thereby in the simplest this disposable glove, latex itself is unique tackiness agent.Gloves contain have an appointment 90 to about 95% latex and about 5 to about 10% calcium hydroxide.Synthetic or natural rubber combination may comprise solvent and rubbery component, though add calcium hydroxide, still can keep enough flexibility to constitute the thing disposable glove of killing livestock of usefulness.Softening agent can add in the latex, to prepare the disposable glove of enough flexibilities.It is about 100 parts of latex fluid that the example of this disposable glove is formed, about 25 parts of calcium hydroxide powder that are scattered in wherein, and the softening agent of appropriate amount.This gloves contain has an appointment 33 ¹/ ₃% calcium hydroxide (measuring) based on drying solid.

This can generate flexible latex glove, and it is having in the presence of the moisture, can have antimicrobial acivity and spore kills activity.If Working environment can not provide suff water, then the wetting agent with appropriate amount adds in the composition of disposable latex glove, makes it have the anti-microbial effect of expection.For the gloves that hope has other type of permanent validity, must comprise carbonic acid gas barrier (for example Mierocrystalline cellulose) as component.This can influence other components in proportions.

Should be appreciated that the people is difficult to tolerate the alkalescence of the individual layer gloves that flooded hydronium(ion) oxidation calcium, can use multilayer in gloves if when gloves contact people's skin, keep the skin of basicity away from the people.Make the wearer discomfort or stimulation is arranged if confirm the basicity of calcium hydroxide layer, can add internal layer to latex glove, this internal layer comprises the latex that does not have calcium hydroxide.For example, skin can have the calcium hydroxide of a large amount of hydrations, and internal layer does not have the calcium hydroxide of hydration fully, or the calcium hydroxide of the hydration that has in a small amount manyly.These layers meeting makes outer field biocidal effect maximization, and internal layer is minimized the undesirable action that skin causes.

Embodiment 5

The thing working suit of killing livestock.

Biocidal apron, trousers, shirt and other clothes are useful for die Postangestellter, medical science staff, food-processing staff, meat Package person etc.Demand to this class clothes of these staff that can effectively kill anthrax and other poisonous spore is not met yet.

Those skilled in the art can understand, compare with the coating that is used on the horizontal surface of the present invention, in disposable glove or the thing latex of killing livestock that uses on the clothes have such solvent, rubbery agent, or make gloves or clothes have enough other flexible required compositions for their intended purposes.Cost consideration may be tended to the application of layered coating.The skin of this layered coating contains the calcium hydroxide of the hydration of the preferred amounts that is useful on the thing purpose of killing livestock.Internal layer can provide intensity, flexibility etc., and as outer field basic unit.

By any known technologies useful, for example spraying, coating etc. can be applied to clothes with killing biostrome.Clothes can be disposable, produces the multiple option that this paper other places are discussed.The biocidal composition that clothes can be discussed by this paper other places is fully formed.Those skilled in the art can understand, can change the amount and the ratio of latex, flexible composition, wetting agent and calcium hydroxide, up to mechanical integrity that reaches hope and biocidal activity.By adding the carbonating barrier that this paper discusses, can have long-term effectiveness.Coating of the present invention is bonded fabric preferably, and very soft and sense of touch is good.Those skilled in the art can determine anti-microbial properties and other quality by conventionally test.

Embodiment 6

Kill livestock thing strainer and baffle plate.

With the thing coating of killing livestock of the present invention, can usefully flood and apply strainer and baffle plate.This strainer can have permeable or coarse basic unit, the thing coating of killing livestock of the present invention can be mixed on their surface or in their matrix, for example the air filter of being made up of the thin bar of Mierocrystalline cellulose or fiberglass or microgrid silk.The strainer of even now is applicable to commercial HVAC system, this strainer also can be installed by usual resident family in his air-conditioning system, described strainer was handled with calcium hydroxide coating of the present invention, made the room safer for airborne microorganism and spore.Baffle plate can be used for the spore that recycle gas (for example air) carries secretly and increase the interaction of circulation spore and the thing calcium hydroxide of killing livestock, and the two all is to place on the baffle plate and because baffle plate is directed to other thing coating of killing livestock with spore by the thing coating of will killing livestock.Static can be used for airborne microorganism is adsorbed onto coating.

If strainer is wished life-time service, for example, in the HVAC of buildings system, the thing coating of killing livestock in the strainer can need Mierocrystalline cellulose as herein described or cellulose family tackiness agent, avoids the carbonic acid gas influence with protection calcium hydroxide.On the other hand, if for example Antigas mask filter wishes to have only short-term validity, the thing coating of killing livestock does not need Mierocrystalline cellulose or cellulose family protectiveness tackiness agent.

Embodiment 7

The thing HVAC system of killing livestock.

Those of ordinary skills will appreciate that, heating and ventilation and air-conditioning (HVAC) system component or lining and not the internal surface of the tubing system of lining fungi and bacterial growth can take place.In addition, independent duct cleaning can not provide enough protections, to antimycotic or bacterial pollutant regrowing on fiberglass lining of pipe line (FGDL).Existing recommendation regulation about the pipeline material of correcting fungi or bacterial contamination is removed this material fully.But the removal of polluting material may be very expensive.Therefore, the common practice in of duct cleaning industry is, uses antimicrobial topcoating after cleaning, and its implication is that they can retrain or limit fungi or bacterium regrowing in the HVAC system.Almost do not handle the information of the effect of the pathogenic agent of Type of Danger (for example anthrax spores) more about these.

Because anthrax spores are propagated by constructure heating heating ventilation and air-conditioning (HVAC) system component, the people can infect anthrax.Suppose,, can propagate between the zone of buildings by the HVAC system by the pre-anti-spore in cheap ground with all or at least HVAC pipeline of significant part of thing applying coating of killing livestock of the present invention.

By spray or otherwise apply their inside with the thing coating of killing livestock of the present invention, set up passive, persistent and not expensive anthrax and kill system, the renovation of HVAC pipeline is improved with killing spores.The thing coating of typically killing livestock in the pipeline has and the different composition of aforementioned biocidal wall paint.It does not need pigment, and it does not need attractive in appearance.Thisly kill livestock that what be concerned about most during thing coating is to kill the anthrax spores that are present on the pipe surface producing.Thereby coating can comprise cheap strainer and coarse weighting agent etc.It can be unusual porous.It should enough be stablized, and to stick on the HVAC side opposite, can not peel off or efflorescence, causes to be blown into the indoor fragment of buildings.Can take all possible measure, to set up surf zone at an easy rate, contact and killing spores, and destroy ducted lamina air flow, make the spore count maximization on contact coating surface.The thing coating of killing livestock of the present invention that is applied in the HVAC pipeline is than the described lower material of thing wall paint cost of killing livestock.

Preferably destroy the ducted laminar flow of HVAC, contact the thing coating of killing livestock as much as possible with the spore of guaranteeing better to carry in the recirculated air.Can add baffle plate in pipeline and alleviate laminar flow, this realizes by the turbulent flow that increases fluidizing air.Baffle plate itself can scribble the thing coating of killing livestock.Most of HVAC pipe interiors are made of metal.When pipeline is metal, regulate the thing system component of killing livestock, yet with bond surface the most at an easy rate most effectively.Being applicable to the material of clagging to the metal, is that the paint field technician is well-known.

Those skilled in the art can understand, except being used for new building, the thing coating of killing livestock of the present invention can usefully be used to renovate existing HVAC system, wherein take off HVAC entrance and exit turbogrid plates simply, and sprinkling, foam or otherwise apply calcium hydroxide, Mierocrystalline cellulose and wetting agent and the suitable mixture of the tackiness agent (for example, latex) selected passes through pipeline.Suppose that making the thing foam of killing livestock is the effective means that applies total inner surface with the thing coating of killing livestock at an easy rate by the HVAC pipeline.As required, can repeat this processing termly.After reinstalling turbogrid plates, this can provide method and the material that spore kills system renovated in the existing HVAC system of buildings, and this is invisible, passive, persistent and cheap.Those of ordinary skills can understand that the present invention also is the coating that is applicable to other HVAC system component, comprising: return air chamber; New air chamber mixing cassette air chamber; Coil chamber; Fan housing; The condensation fan; Humidifier; Moisture extractor; The spraying eradicator; Filter hood; Window shutter; HVAC air feed pipe and backwind tube; The air door adjustment sheet; Vapor pipe; Air door; Fan shield; With wall and floor board ventilation plant trave sheet.

Embodiment 8

The variation of surfaceness and porosity

Existing kill livestock thing coating and paint be designed to wash with attractive.They are not designed to have high porosity or bigger surface-area or cheap in elementary object.But, for the sightless or surface that do not need level and smooth and washing usefully, kill biostrome than described the present invention more coarse and porous more of thing wall paint of killing livestock, because bigger roughness and porosity can increase killing surface-area and reducing its cost of coating.

Sometimes usefully, increase the roughness on the calcium hydroxide surface of the thing coating of killing livestock.This can increase and can interact with spore and at the surface-area of deactivation spore biologically.For this reason, big relatively inertia or active fragments are placed be applied in the pipeline or other lip-deep calcium hydroxide mixture.After the coating drying, the roughness that these fragments cause can provide the bigger turbulence measure of killing surface-area and flowing through the air of coating, to destroy laminar flow, further increases spore and contacting of biostrome extremely.

Simultaneously, the outer key coat of the thing coating of killing livestock of the present invention can be designed to increase antimicrobial acivity, and does not limit washability and magnetism, or only more cheap by the component beyond deletion Mierocrystalline cellulose and the calcium hydroxide.Like this more cheap, more coarse, more the porous typically used of killing biostrome is in HVAC pipeline or strainer.

Embodiment 9

The combination of biocide

The validity of the ability of killing anthrax spores of the system system of killing livestock of the present invention may depend on the amount of the time that anthrax spores contact with the thing coating surface of killing livestock.Other antimicrobial system and anthrax are killed for example microencapsulation of hydrogen peroxide, colloidal silver etc. of system in the system of the killing livestock system, can be used to kill the biology of collision.Be not bound by theory although do not wish, the different spore systems of killing can be used in combination with the system system of killing livestock of the present invention, for example add hydrogen peroxide+colloidal silver etc., or its some combinations, more anthrax spores or other microorganism can in the shorter time period, be killed.It may be important quickening killing effect, may be limited because the time period on surface is killed in the spore contact.The combination system of killing may be specially adapted to for example interior surface of pipeline, and at this moment outward appearance is not a Consideration.

Embodiment 10

The food preservation that improves

By packaging foods in the wrapping material with thing coating of killing livestock based on lime of the present invention, can postpone the corruption of this food.The photochrome that accompanying drawing shows has been explained and has been used the putrid useful result who comes delay product based on the thing coating of killing livestock of calcium hydroxide of the present invention.The product that shows in the photo is sealed in the container, and the internal surface of one group of container scribbles the lime of the present invention thing coating of killing livestock; The internal surface of control container is unprocessed.Product in the container of handling reduces corrupt, easily sees corruption and contrast undressed container contents.The lime that uses in wrapping material in this way can not have any deleterious effect to product or people's health.Use such packing to postpone food and degenerate, satisfied the needs of recognizing for a long time and feel for a long time.The thing packing of killing livestock of the present invention is near more from food, and effect is good more.Suppose that this is because alkalescence is killed surface energy and contacted the airborne transmission bacterium of vast scale more and be present in the product near zone other and cause the putrid factor.In one embodiment, the calcium hydroxide of q.s is mixed in the plastic paint, the latter directly applies to food.

With the inboard of kill livestock thing applying coating refrigerator, refrigerator, ambry or other food storage container of the present invention, can reduce the bacterial count in these enclosed spaces for a long time.Rubber on refrigerator and the refrigerator door or other elastic sealing strip, and, need bioguard treatment especially at other elastic sealing strip of door, window edge and other closable edge of opening.Such sealed strip often accumulates microorganism, because moisture and nutrition accumulate in here.The system of killing based on lime of the present invention is specially adapted to such sealed strip.Calcium hydroxide can be coated on the sealed strip, or integrally produces in sealed strip.Under any situation, composition of the present invention can provide nontoxic and resilient, the cheap and persistent sealed strip of animal.

Embodiment 11

Decontamination immediately

Existing method of killing the anthrax spores in the contaminated buildings is to use very stifling this buildings of poisonous gas dioxide peroxide.As discussing, kill the trial that dry spore (for example anthrax spores) are killed in agent (for example chlorine dioxide) with dried, use unsuitable mode to attack to be in the microorganism of high defensive state.In addition, the pathogenic microbes that kill may be grown in this zone surely, forms piece or microbial film.Decontamination gas and even many toxicity fluids, can kill the outer microtube biology of these bacterium colonies, but shielded internal layer microorganism survives still.If re-use identical decontamination method, remaining microorganism may more be difficult to kill by the protection of the outer microtube biology of natural selection and hard death.Thereby, existing decontamination method is expensive, uses toxic materials, uses unsuitable method to attack to be in the microorganism of high defensive state, and must thoroughly discharge from the decontamination zone, make this zone not have defense pollution incident in the future or any remaining microbiological contamination diffusion.

In some cases, may more wish to contain foam or other carrier to one zone of calcium hydroxide by sprinkling, comprise floor, wall, furniture etc., should the zone decontamination.Because decontamination mixture of the present invention is based on water, it can cause the spore of contact to enter nutritional status, and at this moment their easier basicity by calcium hydroxide is killed.Such decontamination foam or other carrier can be pressed into the HVAC pipeline, rest on then in the HVAC pipeline, with for good and all with they decontaminations.In other cases, also spraying or the mist that comprises the calcium hydroxide of latex or water-stable a zone be can be blown into, kill microorganisms and preventing disease come.

Mainly comprise the calcium hydroxide of water and appropriate amount and foam or other carrier of pore forming material, can usefully kill the spore that is in contact with it.Work by the lethal basicity of passing on it because calcium hydroxide is handled, it sees through each layer of microbe colony and microbial film all is effectively, can kill all microorganisms in the bacterium colony, comprises inner most microorganism.These are different with some existing decontamination method, and the latter only kills the outer microtube biology of bacterium colony, and the remaining shielded microorganism of internal layer infects this zone again.The zone that decontamination calcium hydroxide can be applied to want decontamination with forms such as foam, liquid, mist, spraying, mist, gels.Other benefit is that calcium hydroxide decontamination of the present invention is handled and no matter carried in which kind of preparation, all is nontoxic and non-corrosive.

High expanded infusion and liquid volume ratio be 10,000: 1.Because calcium hydroxide is cationic, nonionic surface active agent or pore forming material are preferred.Water in the foam can provide enough effectively barrier, prevents that atmospheric carbon dioxide from causing the carbonating of calcium hydroxide, and its biocidal effect is extended to decontamination buildings or required time of other specific environment.Foam preferably contains the calcium hydroxide of the 10 weight % that have an appointment.This is enough to make calcium hydroxide to cover the almost whole surface of bubble.Bubble is about 3 to about 5 microns or littler.The preferred amounts of tensio-active agent is about 2.5 weight %.Tensio-active agent can be about 2 to about 4 weight %.Those skilled in the art can change this tittle to a certain extent by test.Polypropylene glycol is a preferred humectants, and Mierocrystalline cellulose is a preferred adhesive.The two all is water miscible and hydrocarbon dissolubility.Those skilled in the art can determine the composition that other is suitable for by routine test.

With chlorine dioxide (ClO ₂) room of decontamination, need usually by in the water and strainer, make this very poisonous gas discharge.Use decontamination mixture of the present invention, the dried residual powder of decontamination mixture only is nontoxic Mierocrystalline cellulose/calcium hydroxide powder.After the room drying, the Mierocrystalline cellulose of vacuum sucking-off easily/calcium hydroxide powder is not to environment or to decontamination personnel's danger.

After rinsing out chlorine dioxide fully from the decontamination room, the not remaining thing reagent of killing livestock.The remaining calcium hydroxide in a small amount of decontamination system of the present invention is in crack and slit, and described calcium hydroxide is subjected to the cellulosic protection of a small amount of that decontamination foam, fluid, mist etc. comprise and avoids carbonating.Thereby, be not only safe with the environment of system of the present invention decontamination, it for spore in the future than safer before polluting.This provides a true benefit, and is the people's great inducement of getting back to previous contaminated environment that was subjected to threatening.

Lime can produce the saturated solution of about .2g/100cc, and it has enough basicity (pH12.4) and kills most of resistance spores and biology.(it is a kind of very poisonous gas as dioxide peroxide, and substitute needs decontamination widely), (it freely rises to top layer, makes solid be separated into the bottom to spray lime water saturation supernatant liquor, contain .185g/100cc) water smoke, can kill resistance spore and biology.Lime water clarification saturated solution (pH12.454) surface be can be applied to, the very spore and the biology of resistance killed.This can remain small residue calcium hydroxide from the teeth outwards, and it can be wiped afterwards.This same solution can be used for cabinet and the fixture that wiping is difficult for using water spray.This solution wetted rag also can the clean surface.Add cellulosic component, persistent antimicrobial resistates can be provided.

There are a substantive issue in inhabitation and pattern of trade about correction is polluted by microorganism (for example mould and fungi).Coating as herein described, material and processing can be used to prevent such problem and correct such structure.

Embodiment 12

Long-acting cleaning

Be possible apply calcium hydroxide coating of the present invention on the surfaces contaminated with the another kind of method of a regional decontamination.This can be from the predetermined extremely urgent decontamination of known Polluted area of brushing again of the routine in hospital and room, rest home.With coating brushing of the present invention or otherwise apply a zone, can be with should the zone decontamination.Calcium hydroxide coating of the present invention has enough calcium hydroxide and suff water, makes calcium hydroxide can kill lip-deep any biology of coating, and no matter described biology is a virus, spore, mould, fungi or bacterium.And the calcium hydroxide in coating does not kill under their the unlikely situation fully, uses the lip-deep any causal organism that can isolate brushing based on the coating brushing surface of calcium hydroxide.Schmutzdecke can be that contain pigment or transparent, and can be applied to wall, top ceiling, floor, furniture etc.Safer before initial pollution of zone ratio by coating coating decontamination of the present invention, because it all has the antimicrobial coating that works now on all environmental surfaces.Compare with the zone that only purifies with deleterious chlorine dioxide purge, such decontamination zone is easier to return the staff of migration and resident after pollution incident.

In addition, behind zone of coating brushing based on calcium hydroxide of the present invention, subsequently can be by only coming decontamination with the surface of moist rag wiping brushing.Moist rag can be taken away some biologies, virus, bacterium, mould, fungi etc., and dispose.But in addition, the humidity meeting of rag: (1) makes the hydration status and (2) that enter them based on any biology on the coated surfaces of calcium hydroxide that suff water is provided, and transports into biology to allow hydroxide ion from calcium hydroxide, with kill microorganisms.

Because the coating based on calcium hydroxide of the present invention does not use expensive component or deleterious component, can there be negative side-effects ground to realize or brushing is regional again with calcium hydroxide coating of the present invention brushing.

Embodiment 13

Decontamination and medical soap

The human early stage many soap that use are based on alkali lye.But the makeup industry usually can production high alkalinity soap now.A new purposes of the system system of killing livestock based on lime disclosed herein is high lime, high pH soap, its be used for especially when the thing soap of wishing to kill livestock can kill fungi, the situation of mould spores or other biology that is difficult to kill.Non-ionic type soap for example based on the soap of glycerine, in conjunction with the tensio-active agent and the calcium hydroxide of appropriate amount, can be produced useful soap bar, and it has about pH12 or basicity bigger, preferred pH12.4-12.5.Glycerine or similar substrates can prevent calcium hydroxide because contact and be neutralized with atmospheric carbon dioxide.Soap kill livestock the thing shelf-life thereby very long sustainable several years.When using soap, when promptly combining also front and back friction with water, the thing of killing livestock that provides that water and moist calcium hydroxide can provide this paper to discuss kills the required very high alkalescence of system, and this is enough to kill microorganisms, comprises spore.

Suppose, the described soap that contains enough calcium hydroxide can provide about pH12 or higher high alkalinity in use, and it can be used for when the end on duty cleaning by people such as die Postangestellter or medical personnel, with thorough killing bacteria and other biology, even comprise the spore that is difficult to kill, for example anthrax.Suppose the topical application of such soap, other surface and the surperficial disease down that can treat wart, acne, tinea pedis, fungi effectively and cause by the external microorganism that is difficult to kill.The emulsifiable paste of this purposes preferably can be applied to skin 7-10 days, although can use-testing change pH and time length.

Embodiment 14

Preventing infection

In the hospital or hospital acquired infections be normally defined, the patient go into hospital or other health care place after 3 days or the infection that occurs first more of a specified duration.In the U.S., the acquired or nosocomial infection of hospital can take place in a large amount of inpatients.Have impaired immune child, the such infection of the elderly's most probable generation.Other Hazard Factor comprise the long-term conduit of being in hospital and using long duration.In every year, estimating has 2,000,000 patients that nosocomial infection can take place at United States Hospital, causes to surpass 100,000 people's death.These infect cost is annual about $45 hundred million.

The deleterious algae of possibility, bacterium and fungi can rest on the desiccated surface, and no matter this surface is coarse (a for example fabric) or slick (for example plastics).Surface such in the medical space comprises lab-gown, towel, secret curtain, clothes, the washing clothes, care appliances, apron, computor-keyboard, the computer cover, medicine equipment, wall, top ceiling, the floor, pipeline, pen, pencil, phone, chart, doorframe, conspicuous other surface of handle and those skilled in the art.In addition, some germ develops immunity to drugs gradually, thereby more difficult elimination behind infected patient.Therefore, the practical approach for reducing nosocomial infection exists the very large market requirement and secular needs.

For the airborne transmission that minimizes in the Operation theatre pollutes, use expensive method sometimes, for example per hour change the high-efficient granule air filtration recycle system of 15-20 air, ultraviolet irradiation, ultrafiltration streaming system etc.Although these systems are used in the Operation theatre sometimes, think that they are because too expensive and be difficult to use in whole hospital or other medical space.This has explained that the expensive step of medical profession can reduce the probability of the infection that hospital causes.

The all surface of hospital all may carry microorganism, and no matter they are service plate, patient's hand, secret curtain, clothes, computor-keyboard etc.Can there be several weeks in some microorganism, especially fungi on the hospital surface, wait for an opportunity to transfer on the susceptible patient.In order to spread the faecalis and the staphylococcus microorganism (pathogenic agent of the greatest problem of nosocomial infection) of dangerous antibiotics resistance, microorganism only needs static place to contact them or upset them with some object usually, so that they are conveyed to the patient.Think that the surface is the main carrier of disease, be only second to people-people's contact.

Although by reducing property, carried out some and made other fabric in hospital's robe and the hospital be difficult to carry the effort of microorganism, still need to make clothes and the fabric more are difficult to carry the microorganism that can cause nosocomial infection.

As mentioned above, can be with of the present invention based on all surface in the latex paint brushing hospital of lime.This comprises wall, floor, top ceiling, HVAC system.But in addition, coating of the present invention also can usefully be applied to handle, medicine equipment, and worktable, computor-keyboard, the plastic cover of computor-keyboard, the secret curtain, blind, curtain, hospital furniture, gatekeeper's equipment and subsidiary material, etc.This several hospitals surface and surface well known by persons skilled in the art can usefully comprise, scribble the paint based on calcium hydroxide or lime of the present invention, material or cleaning liquor, or handle with them.

Existing standard method of killing lip-deep microorganism is, with 10% sodium hypochlorite solution disinfecting surface.SYNTHETIC OPTICAL WHITNER is always not useful for the furniture in coloured fabrics, carpet, visitor zone etc.Coating of the present invention and handling in the practice and all better on attractive in appearance than sodium hypochlorite solution.

Textile material for example furniture, the Medical Treatment Area of robe, visitor chamber chair, etc., can comprise or scribble coating of the present invention, realize secular anti-microbial effect, and subsequently with processing washing of the present invention.Add SYNTHETIC OPTICAL WHITNER to building surface, can increase the moisture content of matrix, the result causes the induced environment of other microbial population, especially fungi (mould).

At medical treatment situation, the common source of opportunistic infection is conduits and partly keeps other medical treatment device of Long contact time with the susceptible of patient body.Such object can scribble or comprise material of the present invention, makes this object can not carry microorganism, also can not contain the toxin of other antimicrobial coating.

The object that is made of plastics at present, secret curtain for example, blind, computor-keyboard, hand rest dish, computer cover, the counter top, handles etc. can be integrated coating of the present invention and substrate material and produce, and maybe can be coated in coating of the present invention on the substrate material in process of production or are applied in the hospital.Application in hospital can be by smearing or spraying; Once or regularly.

As a way of illustrative example, computer monitor and keyboard are present in each intensive care unit.For the patient with lower demand, computer monitor and keyboard are present in each nurse station.When each inspection or treatment patient, access and input information from computer by computor-keyboard.Often touch supervising.Need to read paper instruction and record, work in the above, filing is accepted etc.The medical worker may change disposable robe and mouth mask carefully between the patient, but often uses all day such as same pen, pencil, little torch light, stethoscope etc., continues the several months.These objects also can be protected with coating of the present invention, material and processing.

Those skilled in the art can understand that the coating of the present invention that is used for these devices must be designed to can not stimulate patient or medical worker, and still for the surface provides enough basicity, if basicity is not enough to kill microorganisms, suppress to I haven't seen you for ages microorganism decide grow.

These and other anti-infectious preventive measures also can be used for conspicuous other place of veterinary clinic, nursing unit, rest room, ambulatorium and those of ordinary skills.

Embodiment 15

Induce nutritional status

The work of MSU's report confirms that nutritive compositions can be applied to cause spore to enter nutritional status on the surface.When microorganism is in nutritional type rather than spore state, their easier killing.But, the technical requirements of MSU, any such surface must be handled with biocidal material or composition subsequently, to destroy the nutritional type cell.But the thing coating of killing livestock of the present invention can be united use with nutrition and wetting agent, spore is changed into nutritional status, and kill them by the basicity of coating.Applied nutrition composition and/or moisture do not need to use the new thing coating of killing livestock termly.

Another aspect of the present invention is at first to give the coating of surface coverage this paper discussed above, subsequently to the moist nutritive compositions of its application.If nutritive compositions is applied thereon the coating of the present invention of spore, this nutritive compositions contains suff water, enters nutritional status at first to cause spore, and guarantees the destruction of spore and any nutritional type cell subsequently.This need not use the thing reagent of killing livestock in addition after using nutritive compositions.

In some embodiment of the present invention, water and nutrition can be added in the environment, for example by atomizer, cascade, etc., improve validity of the present invention.Suff water can add in the air, and the wetting agent that kills in the biostrome with abundant hydration kills on the spore or microorganism of biostrome to contact.In other embodiments, for example may be in the HVAC pipeline, the nutrition mist can be directly used in the nutritional status that spore is changed into bacterium.Atomizer can for example be fixed and be limited on the HVAC pipeline.In case bacterium is in nutritional status,, can more easily kill them by the basicity of contact based on the coating of calcium hydroxide.

Embodiment 16

The virus protection

Alistagen company has carried out virus research, research SWRI-96-01, scheme SWRI062096, meet GLP rules (Title 21 CFR 58), to determine the antiviral activity of Caliwel BNA (being called Caliwel or BNA) microbiotic paint or coating, the latter brushes on plastic deeping, and carries out drying.As a result, by being exposed to trier BNA water-based paint and trier BNA solvent based paint, in 1 hour deactivation poliovirus 1 type, human herpesvirus 1's type and haemadsorption virus 1.

Poliovirus, herpes virus hominis, and parainfluenza virus.Carry out virus research and determine the antiviral activity of Caliwel paint or coating, the latter brushes on plastic deeping, and carries out drying.Such antiviral activity can be used for building surface, and for example wall, floor, top ceiling, heating and ventilation system surface or other such surface may be subjected to the environment of virus pollution.Select the representative of poliovirus, herpes virus hominis's (hsv) and parainfluenza virus as 3 virus groups, these 3 virus groups have different biological properties and the different taxises of organizing, cause central nervous system, mucous membrane or respiratory tract infection, for example bird flu.

The purpose of research is, determines to be exposed to when being covered with Caliwel BNA microbiotic paint surperficial when virus, and whether trial target paints sample can inactivated poliovirus 1 type and haemadsorption virus 1 infectivity.Such antiviral activity is applicable in the environment of potential human pathogen possibility contaminated surface.Polluted surface is the main carrier of disease (for example bird flu or H5N1 virus), is only second to fowl-people-people's contact.The present invention relates to the mode of crossed contamination chain first kind of safety, and cut-out bird flu Noninvasive and H5N1 virus harmless to humans and animals.By with the Caliwel BNA coating treatment of hard surfaces inside of wall, floor, top ceiling and heating and ventilation and air-conditioning system for example, can prevent or significantly reduce transmission of disease, and the people who is exposed to contagion virus is minimized.

Select the representative of poliovirus, herpes virus hominis's (hsv) and parainfluenza virus as 3 virus groups, these 3 virus groups have different biological properties and the different taxises of organizing, and cause central nervous system, mucous membrane or respiratory tract infection.

Fig. 5 has shown the trier that scribbles BNA water-based paint (Fig. 5 A), BNA solvent based paint (Fig. 5 B) and Control paint (Fig. 5 C) by being exposed to, inactivated poliovirus 1 type (LSc 2ab).

Fig. 6 has shown the trier that scribbles BNA water-based paint (Fig. 6 A), BNA solvent based paint (Fig. 6 B) and Control paint (Fig. 6 C) by being exposed to, deactivation human herpesvirus 1 type.

Fig. 7 has shown the trier that scribbles BNA water-based paint (Fig. 7 A), BNA solvent based paint (Fig. 7 B) and Control paint (Fig. 7 C) by being exposed to, deactivation haemadsorption virus 1.

Be exposed to behind the trier Caliwel in 60 minutes, deactivation poliovirus 1 type, human herpesvirus 1's type and haemadsorption virus 1.Although do not wish to be bound by theory, Caliwel can deactivation the N5H1 strain, and be widely used in the humans and animals protection of various ways.This purposes of Caliwel is the form of building coating or paint.U.S.EPA has allowed the registration EPA Reg.No.73696-2 of this product, and EPA Est.No.74842-NC-Ool is as antimicrobial architectural paints.From 2003, this product appeared on the market.

Trier, 2 kinds of paint sample (the water base and BNA solvent based paint of BNA-be Caliwel) are applied on the plastic sheet, test the ability of their 3 kinds of viruses of deactivation (poliovirus 1 type, human herpesvirus 1's type, and haemadsorption virus 1).The suspension of virus is placed on the 25mm square plastic flakes that scribbles 2 kinds of trier coating.0,5,10,15,30 and 60min after, collect viral sample, whether test exists infectious virus.Also virus is placed on the plastic sheet that does not have biocide (BNA contrast) paint in contrast.

The BNA water-based paint in 30 minutes deactivation 10 _8.7TCID ₅₀Poliovirus, in 5 minutes deactivation IO _5.7TCID ₅₀The herpes virus hominis, in 30 minutes deactivation 10 _7.7TCID ₅₀Parainfluenza virus.Need 60,30 and 15min 3 kinds of viruses of coming the deactivation same amount based on the paint of solvent.Comparison film does not produce inactivation of virus after exposing 1 hour.

Wash-out advances to add the component of giving 2 kinds of paint in the substratum of trier sample in 10-15min, is deleterious for the cell culture that is used for virus research.Square 10min by washing paint brushing in removing the water of mineral substance can significantly reduce this toxicity.Adopt this method to test.

The purpose of research is, determines to be exposed to when being covered with paint surperficial when virus, and whether sample is painted in test can inactivated poliovirus 1 type, the activity of human herpesvirus 1's type and haemadsorption virus 1.

Trier.Two kinds of trier paint have been studied.Receive trier BNA water-based paint and BNA solvent based paint on June 21st, 1996 and on July 10th, 1996 respectively, brush on the plastic sheet that separates about 40 * 30cm size.Receive the contrast plastic sheet that contains the BNA contrast on June 20th, 1996.

By identity, the intensity of promoter's determination test thing, form, purity and stability.

10 times of viral dilution liquid of virus are exposed to paint and BNA contrast plastic sheet.The viral dilution liquid of taking a sample at interval is to determine the point of complete inactivation.

With paper knife trier (being made up of the paint that is applied on the plastic deeping) is cut into 25 * 25mm side and determines, be deposited in envelope standby in room temperature square.Plastic sheet Control paint (BNA contrast) also is cut into 25 * 25mm square, standby in the room temperature preservation.

The antiviral activity of test paint.Before using, washing test thing and contrast square 15min in about 100ml deionized water are to remove Cytotoxic material.After blotting on the paper handkerchief, the square of every kind of trier and contrast is placed each hole of 6 aseptic holes (35mm diametric hole) polystyrene cell cultures dish.For the square of every kind of paint is prepared 2 flat boards (being used for viral determination test thing with cell culture medium determination test thing---cytotoxicity contrasts), and 1 flat board contains BNA Control paint plastics square (containing the contrast of virus).For every kind of virus, the inactivation of virus of revision test thing flat board and contrast.

Based on test virus (human herpesvirus 1's type, poliovirus 1 type and haemadsorption virus 1) the prediction titration, 10 times of diluents are prepared into the end points of tiring, 6 kinds of highest dilutions 2.0ml aliquots containig are separately placed one of 6 holes of trier and contrast flat board.The toxicity control wells 2.0ml substratum (the EagleShi MEM contains 10% foetal calf serum) of packing into.In each case, by swing plate, viral suspension and control medium are distributed on the surface of plastics square.

The 0.2ml sample is taken out in compartment of terrain (0,5,10,15,30,60 minutes) from each hole, the permissive cell culture (0.1ml/ hole) in 2 holes of 24-well culture plate is advanced in inoculation.For herpes virus hominis and poliovirus, use the MA104 cell, for haemadsorption virus 1, use Vero (E6) cell.

The cytopathology (CPE) or the Cytotoxic evidence of the culture of inspection in every 2-3 days inoculation continued for 1 week.Each check test thing and the toxicity (toxicity contrast) of comparison film and any evidence of tiring of every kind of virus.

Use poliovirus 1 type (bacterial strain LSc 2ab) preparation test virus base, wherein the 0.5ml seed virus is inoculated on MA 104 cell monolayers in the T-25 polystyrene Tissue Culture Flask.In 37C incubation flask 1 hour, in flask, add 10ml substratum (EMEM).Flask is returned 37C, when cytopathology is 4+, freeze thawing flask 3 times.At the centrifugal substratum 15min of 1500rpm, supernatant liquor is used to carry out following titration.

With with preparation poliovirus storehouse identical mode, preparation human herpesvirus 1's type (bacterial strain Mayo) work virus base.

By 0.5ml virus seed being inoculated on Vero (E6) cell monolayer in the T-25 polystyrene Tissue Culture Flask preparation haemadsorption virus 1 (bacterial strain SF4) work storehouse.In 37C incubation flask 1 hour, in flask, add the 10ml substratum.Flask is returned 37C, when record 3+CPE, gather in the crops.Freeze thawing flask 3 times at the centrifugal substratum 15min of 1500rpm, is used to carry out following titration with supernatant liquor.

(cellgro, (Summit, S-100-65), MA 104-RhMK clone goes down to posterity 54-56 time the MEME-EagleShi minimum essential medium, is grown on the MEME 10-010-LM) to contain 10% foetal calf serum.Vero (bacterial strain E6)-African green monkey kidney cell line goes down to posterity 32 and 33 times, is grown on the MEME.

IV result:

Poliovirus 1 type inoculum has tires 10 _7.5TCID ₅₀Therefore (50% tissue culture infective dose end points)/0.1ml, in 2.0ml is applied to virus on every kind of paint sample, uses 10 _8.7TCID ₅₀The virus of this amount is inactivated after being exposed to BNA water-based paint 30min, is inactivated after 1 hour being exposed to BNA solvent based paint, is exposed to the contrast plastic sheet and does not influence virus (Fig. 5 (A-C), table 1).

Herpes virus hominis's (hsv) 1 type has tires 10 _5.5TCID ₅₀/ 0.1ml or 10 _5.7TCID ₅₀/ 2.0ml test volume.The virus of this amount is inactivated after being exposed to BNA water-based paint 5min, is inactivated after being exposed to BNA solvent based paint 30min, is exposed to the contrast plastic sheet and does not influence virus (Fig. 6 (A-C), table 2).

Haemadsorption virus 1 has tires 10 _6.5TCID ₅₀/ 0.1ml or 10 _7.7TCID ₅₀/ 2.0ml test volume.The virus of this amount is inactivated after being exposed to BNA water-based paint 30min, is inactivated after being exposed to BNA solvent based paint 60min, is exposed to the contrast plastic sheet and does not influence virus (Fig. 7 (A-C), table 3).

Trier paint is being exposed in the MEME 10-15min, is being enough to kill the resting cell of exposure from the toxic materials of paint wash-out.By remove in the mineral water their 15min of washing at about 100ml, can remove this overt toxicity from the paint square.

The H5N1 avian influenza virus.The present invention can expand to the virus of other type, for example the H5N1 avian influenza virus.According to the World Health Organization, be to contact with the surface and the direct of object of infected poultry or their fecal pollution from bird " main path of infected person ".The expert estimates, if the ability that H5N1 sudden change and obtaining is easily propagated between people-people can make that to surpass several hundred million people seriously ill, and kills them.Infect among this viral people at all, H5N1 has 55% mortality ratio, and comparatively speaking, spanish influenza only is 6%.Since 2003 later six months, in 4 Asian countries, bird flu killed or shakedown tens million of poultry.The expert says that it is sudden change stably, and probably it finally can obtain easily to propagate required variation between people-people.According to the prediction (2005.10) of the World Health Organization, if like this, its can the several months or even several weeks in mop up All Around The World, world population is reduced 1/3.What announced last week studies confirm that, (it has caused flu outbreak in 1918 to H1N1 virus, at least 4,000 ten thousand people have been killed in the whole world, and according to estimating to have killed more people) be a kind of pure avian viruses, it has obtained several sudden changes, and these sudden changes make it obtain infected person easily, propagate and cause the ability of high mortality disease between the crowd.H5N1 is sudden change in a similar fashion, and it also easily before the infected person, only is matter of time that the expert thinks at it.

When flowing out influenza virus in saliva, nasal discharge and the ight soil of infected bird at them, the bird flu meeting is propagated.When the susceptible bird contacts contaminated movement or during by manure contamination surperficial, their can be infected.Think that the reason of most of cases of bird flu infected person is infected poultry of contact or polluted surface.

H5N1 virus is infected person not usually.But verified people's contact is from the danger of the H5N1 virus of bird.But,, in the process of the poultry bird flu that breaks out in Hong Kong, found from fowl to anthrochorous first case in 1997.This virus has caused the serious respiratory illness of 18 people, wherein 6 people's death.After this, H5N1 occurs and infected other human case.Recently, in the extensive poultry of H5N1 breaks out, the case of H5N1 infected person has taken place in Thailand, Vietnam and Cambodia.The mortality ratio of the case of these reports is about 50%.The occurrence cause of most of such cases is to contact infected poultry or polluted surface.But, think this specific virus sudden change adult-propagate to-people as yet.But, if the people of H5N1-to-people's variant, World Health Organization's prediction, worldwide popular takes place, and can be cost with several hundred million people's life.

Because these viruses usually can infected person, in the crowd, have faint or do not have immunoprotection them.If H5N1 virus energy infected person, and easily between people-people, propagate, " flu outbreak " (the worldwide of disease breaks out) can be begun.Nobody can predict when may be very popular.But worldwide expert is just in the H5N1 in close observation Asia form, and prepares in the possibility that begins more easily for this virus and propagate between people-people widely.

Also caused people ill and dead H5N1 virus anti-amantadine of energy and Rimantadine at the Asia infected poultry at present, this is two kinds of antiviral that are usually used in influenza.2 kinds of other antiviral oseltamivir and zanamivirs may be used for the treatment of the influenza that H5N1 virus causes.

V. conclusion

In being exposed to trier BNA water-based paint and trier BNA solvent based paint 1 hour, deactivation poliovirus 1 type, human herpesvirus 1's type and haemadsorption virus 1.

VI. show

Table 1: by being exposed to trier BNA water-based paint and BNA solvent based paint, inactivated poliovirus 1 type (LSc 2ab).

The result of a.BNA water-based paint

The viral dilution degree	Viral sample time
							0 time	5min	10min	15min	30min	60min
	10 -1	2/2 a	2/2	2/2	2/2	0/2							0/2
10 -2							2/2	2/2	2/2	2/2	0/2	0/2
	10 -3	2/2	2/2	2/2	2/2	0/2							0/2
10 -4							2/2	2/2	2/2	2/2	0/2	0/2
	10 -5	2/2	2/2	2/2	2/2	0/2							0/2
10 -6							2/2	2/2	2/2	0/2	0/2	0/2

^aPositive hole count/inoculation hole count.

B.BNA solvent based paint test-results:

The viral dilution degree	Viral sample time
							0 time	5min	10min	15min	30min	60min
	10 -1	2/2	2/2	2/2	2/2	2/2							0/2
10 -2							2/2	2/2	2/2	2/2	2/2	0/2
	10 -3	2/2	2/2	2/2	2/2	2/2							0/2
10 -4							2/2	2/2	2/2	2/2	2/2	0/2
	10 -5	2/2	2/2	2/2	2/2	2/2							0/2
10 -6							2/2	2/2	2/2	2/2	2/2	0/2

Table 2: by being exposed to trier BNA water-based paint and BNA solvent based paint deactivation human herpesvirus 1's type (Mayo)

A.BNA water-based paint test-results:

The viral dilution degree	Viral sample time
							0 time	5min	10min	15min	30min	60min
	10 -1	2/2 a	0/2	0/2	0/2	0/2							0/2
10 -2							2/2	0/2	0/2	0/2	0/2	0/2
	10 -3	2/2	0/2	0/2	0/2	0/2							0/2
10 -4							2/2	0/2	0/2	0/2	0/2	0/2
	10 -5	2/2	0/2	0/2	0/2	0/2							0/2
10 -6							1/2	0/2	0/2	0/2	0/2	0/2

^aPositive hole count/inoculation hole count.

B.BNA solvent-based coating test-results:

The viral dilution degree	Viral sample time
							0 time	5min	10min	15min	30min	60min
	10 -1	2/2	2/2	2/2	2/2	0/2							0/2
10 -2							2/2	2/2	2/2	2/2	0/2	0/2
	10 -3	2/2	2/2	2/2	2/2	0/2							0/2
10 -4							2/2	2/2	2/2	2/2	0/2	0/2
	10 -5	2/2	2/2	2/2	2/2	0/2							0/2
10 -6							0/2	0/2	0/2	0/2	0/2	0/2

Table 3: by being exposed to trier BNA water-based paint and BNA solvent based paint, deactivation haemadsorption virus 1 (SF4).

A.BNA water-based paint test-results:

The viral dilution degree	Viral sample time
							0 time	5min	10min	15min	30min	60min
	10 -1	2/2 a	2/2	2/2	2/2	0/2							0/2
10 -2							2/2	2/2	2/2	2/2	0/2	0/2
	10 -3	2/2	2/2	2/2	2/2	0/2							0/2
10 -4							2/2	2/2	2/2	2/2	0/2	0/2
	10 -5	2/2	2/2	2/2	2/2	0/2							0/2
10 -6							2/2	2/2	2/2	2/2	0/2	0/2

^aPositive hole count/inoculation hole count.

B.BNA solvent based paint test-results:

The viral dilution degree	Viral sample time
							0 time	5min	10min	15min	30min	60min
	10 -1	2/2a	2/2	2/2	2/2	2/2							0/2
10 -2							2/2	2/2	2/2	2/2	2/2	0/2
	10 -3	2/2	2/2	2/2	2/2	2/2							0/2
10 -4							2/2	2/2	2/2	2/2	2/2	0/2
	10 -5	2/2	2/2	2/2	2/2	2/2							0/2
10 -6							2/2	2/2	2/2	2/2	1/2	0/2

^aPositive hole count/inoculation hole count.

Table 4: by being exposed to the BNA Control paint, inactivated poliovirus 1 type (LSc2ab), herpes virus hominis and haemadsorption virus 1 (SF4)

A. poliovirus 1 type:

The viral dilution degree	Viral sample time
							0 time	5min	10min	15min	30min	60min
10 -1							2/2 a	2/2	2/2	2/2	2/2	2/2
	10 -2	2/2	2/2	2/2	2/2	2/2							2/2
10 -3							2/2	2/2	2/2	2/2	2/2	2/2
	10 -4	2/2	2/2	2/2	2/2	2/2							2/2
10 -5							2/2	2/2	2/2	2/2	2/2	2/2
	10 -6	0/2	0/2	0/2	0/2	0/2							0/2

^aPositive hole count/inoculation hole count.

B. human herpesvirus 1's type:

The viral dilution degree	Viral sample time
							0 time	5min	10min	15min	30min	60min
	Undiluted	2/2	2/2	2/2	2/2	2/2							2/2
10 -1							2/2	2/2	2/2	2/2	2/2	2/2
	10 -2	2/2	2/2	2/2	2/2	2/2							2/2
10 -3							2/2	2/2	2/2	2/2	2/2	2/2
	10 -4	2/2	2/2	2/2	2/2	2/2							2/2
10 -5							0/2	0/2	0/2	0/2	0/2	0/2

Table 4: by being exposed to the BNA Control paint, inactivated poliovirus 1 type (LSc2ab), herpes virus hominis and haemadsorption virus 1 (SF4).

C. haemadsorption virus 1:

The viral dilution degree	Viral sample time
							0 time	5min	10min	15min	30min	60min
	10 -2	2/2 a	2/2	2/2	2/2	2/2							2/2
10 -3							2/2	2/2	2/2	2/2	2/2	2/2
	10 -4	2/2	2/2	2/2	2/2	2/2							2/2
10 -5							2/2	2/2	2/2	2/2	2/2	2/2
	10 -6	2/2	2/2	2/2	2/2	2/2							2/2
10 -7							0/2	0/2	0/2	0/2	0/2	0/2

^aPositive hole count/inoculation hole count.

Embodiment 17

Termite and insect

Whiting is used to kill flavor fly larva in the world traditionally, because these larval growths are in the bark bag, and underground about 4 feet.By with 4 feet levels of whiting washing, can kill larva.According to industrial source, expection lime washing lotion also can be killed the termite larva of exposure.After short period of time, usually a couple of days and several weeks, lime can be from air absorbing carbon dioxide (CO ₂), the latter can reduce the pH of lime, and lime is changed into lime carbonate (its carbonating).After this natural process, the ability that lime is promptly lost high pH and killed larva or termite.If tree will keep the lime protection and avoid larva, termite and insect, needs often to be applied to again lime on tree.Such process is required great effort very much, and infeasible economically.

Caliwel is designed so that to use the activeconstituents of all positive performances of lime as them.But Caliwel contains the binding mode of the microencapsulation of through engineering approaches especially, is called Bi-neutralizing agent (BNA), and it has the ability that works in the liquid latex system, to stop CO ₂Infiltration, allow water vapour and microorganism to penetrate that BNA is semipermeable, the film of selective permeation simultaneously, here with lime reaction, and cause microbial enzyme to decompose.

Use Caliwel to come nurse tree to avoid its natural enemy, be considered to very useful and economically feasible approach.Lime is the mineral that are derived from the natural generation of soil.In order to keep natural, ecological balance, must address this problem.From the tradition of having set up, do not change the method for 4 feet in coating tree; But,, do not need frequent repeated application because Caliwel keeps high pH.Caliwel has initial pH12.454, and it according to condition, can reduce to pH9 along with year number (4-6) reduces gradually.According to envrionment conditions, every about 4-6 needs Caliwel to handle.Long-term protection like this can keep the natural integrity set, greatly reduces cost and labour simultaneously and consumes.

Embodiment 18

Packing with the nano particle biocide:

Present embodiment relates to the white lime thing technology of killing livestock, it and United States Patent (USP) 6,042,638, United States Patent (USP) 6,280,509 is relevant with United States Patent (USP) 6,231, the 650 described thing coating technologies of killing livestock, they whole especially with referring to mode incorporate this paper into.

Known have pH12 and an above hydronium(ion) oxidation calcium (Ca (OH) ₂, slaked lime, calcium hydroxide) alkalescence be enough to kill biology.But Atmospheric Carbon Dioxide can change into lime carbonate with calcium hydroxide along with the time around, and the latter does not have the basicity that is enough to kill microorganisms.Calcium hydroxide also can play the conventional paint adhesive of degraded.Above-mentioned patent provides coating composition, its: (1) postpones because the carbonating of the atmospheric calcium hydroxide of contact, (2) use can not degraded or be subjected to the tackiness agent of its disadvantageous effect and (3) can see through moisture by white lime, but can not see through carbonic acid gas.

Fully postpone the carbonating speed of calcium hydroxide and be not subjected to the disadvantageous effect of calcium hydroxide and the combination of the selective coating tackiness agent of selective permeation, still can not use all polyolefine latex that especially in paint, use with all tackiness agents.

The technology use of above-mentioned patent and cellulose polymer compound or the combined calcium hydroxide of some non-ionic type polyolefine latex.But this can not be applicable to all materials or function, and only for some material or function, is to reach the kill livestock best mode of produce product of practicality.Still need new method and composition, it allows the nontoxic biocidal effect of calcium hydroxide to be used in best in other material and the function.

In one embodiment, the present invention has finished dual role: postpone the carbonating of calcium hydroxide and use the composition that comprises adhesive material, comprise and often degraded by calcium hydroxide or be subjected to those of its disadvantageous effect.This following realization is made nano particle with calcium hydroxide, and it has the size of 0.1 nanometer to 110 nanometer usually.These nano particles can be added any tackiness agent then, not need special tackiness agent discussed above.Although thoroughly do not understand definite theory, think that the nanometer of calcium hydroxide can make it have physics different with parent material and chemical property.More specifically, although it has kept its basicity and its biocidal properties, polyolefine latex adhesive and other tackiness agent that it can not be degraded and use always in paint, thereby do not need to wrap in advance by cellulose polymer compound, do not need to use non-ionic type polyolefine latex yet as tackiness agent to calcium hydroxide.

By preparing the technology of nano particle arbitrarily, for example whole with referring to mode incorporate United States Patent (USP) 5,783,263 and the United States Patent (USP) 5,585 of this paper into, the method described in 020 can prepare the useful thing nano particle of killing livestock.By routine test, can select only method.

In another embodiment, packing calcium hydroxide is physically to separate it and tackiness agent or carrier.The calcium hydroxide particle of packing must be enough little, and mixing with carrier or matrix phase, and the carrier characteristics that does not influence hope causes carrier to become useless for its intended purposes.The calcium hydroxide particle of packing mainly is the inert particle with carrier, and can substantially not influence the structure properties of carrier unfriendly.In other embodiments, the particle of packing can be designed to advantageously influence the characteristic of carrier.

Any embodiment all allows the basicity of calcium hydroxide to be communicated to fully under coating surface or the adjacent surface, makes that coating is biocidal in the useful time period.Fully postpone the carbonating speed of calcium hydroxide and the combination of the abundant reception and registration of the thing basicity that promotes to kill livestock, make that the method and composition of above-mentioned patent is feasible.

Packing relates to makes fine particle become the interior active core of shell.Packing can be used for scale arbitrarily.The most typically, packing can prevent composition prematurely with they environment reaction or processing or preserving process in degrade.In the present invention, encapsulation techniques is used to protect the calcium hydroxide core material to avoid carbonating, passes on basicity, promotes to handle and disperse calcium hydroxide, and in some cases, allows to continue to discharge basicity for some time of calcium hydroxide.Coating material can be organic or inorganic.Micro-capsule can be hydrophilic or hydrophobic, and is solid or liquid.The packing useful load of biocidal material can be low to moderate 20% or up to 99%.The capsule size can be preferably less than 1 micron extremely up to 2,000 microns, although also can use bigger capsule.Can produce the powder of the calcium hydroxide of packing.For example, if when solidifying, remove coating material by vacuum annealing, the powder that obtains keeps not assembling.

The advantage of the biocide of some nanometer packing of the present invention is that when some capsule was exposed to atmosphere, the protection core particle was avoided oxidation and/or hydrolysis.When packing they the time, but use calcium hydroxide or other biocide blending ingredients as coating or product, produce through regular meeting is greatly convenient.

In another embodiment, the calcium hydroxide of one deck packing is placed on the stromal surface, no matter it be metal or plastics, then, with external coating (EC) place the calcium hydroxide layer above.External coating (EC) has enough saturating property, allows the basicity of calcium hydroxide to be communicated to the outside surface of coating, and also is enough to postpone the time period that calcium hydroxide is avoided the carbonating practicality of ambient atmosphere.Thereby laminated product is feasible, and wherein external coating (EC) protection calcium hydroxide is avoided atmosphere.In a preferred this embodiment, the calcium hydroxide layer of this coating protection can be passed on the thing basicity of killing livestock to the surface at least 30 days.

By calcium hydroxide is encapsulated in the nano particle, can strengthen the oxidation resistant chemical stability of calcium hydroxide.Think that such nano particle can use with the cellulose polymer compound of above-mentioned patent, the product of production has than using United States Patent (USP) 6,042,638; United States Patent (USP) 6,280,509; With United States Patent (USP) 6,231, the longer active phase of product that 650 technology is produced, and the thing of more effectively killing livestock.

The limiting examples that can add the carrier of calcium hydroxide particle of packing and the product that can use or add comprises the substrate material plastics for example that prepare object, wood pulp, paper, and metal; The consumer's goods, makeup for example, toothpaste and thimerosal; Coating for example paints and polishing agent, mud, and sealing agent.The present invention can be used for paper pulp, paper pack, styrofoam class container, glass stationery cover etc.The amount of the calcium hydroxide of packing must be enough to make the end product that obtains to kill livestock the time period of thing practicality preferably at least 30 days.The amount of the calcium hydroxide of the generation useful consequence that provides in the expection above-identified patent and the example of per-cent are applicable to the present invention, need not unsuitable test.

For the product on the thing surface of killing livestock with hope, hospital's curtain for example, apron, shower curtain or ceramic tile or paint, the thing life-span of killing livestock of hope can be the time period of essence behind this product contact atmosphere, preferably at least 30 days.For these purposes, coating material must protect calcium hydroxide to avoid fast together with carrier the atmosphere carbonating repeats to contact with water with possible.On the other hand, for running stores, toothpaste for example, makeup, tooth powder, etc., the time period in the thing life-span of need killing livestock mainly is the shelf-life of product, during this period atmosphere and due to carbonating can packagedly get rid of.After this, when in fact using this product, the biocidal effect time of the reality of this product is shorter relatively.

The another kind of method in the life-span of the thing validity of killing livestock of prolongation product is to use constant or variable slow releasing capsule.Variable delivery system be with the spraying of the produce product of killing livestock of nanometer packing be delivered to the zone that will clean microorganism.

Thereby the purpose purposes of the product calcium hydroxide that determined to need protection is avoided the degree of carbonating and amount volume and the speed that basicity is preferably passed on, and the basicity (calcium hydroxide) that needs storage storehouse.

For the product with the thing surface of killing livestock of the present invention, the particle of packing of the present invention has coating, and carrier of the present invention has enough saturating property, is communicated to the surface with the basicity that allows calcium hydroxide fully under carrier surface, makes the surface of the carrier thing of killing livestock.Although in some cases, the calcium hydroxide of packing can usefully comprise the micron size particle, the present invention preferably comprises the calcium hydroxide of the packing of nanometer size.Think that the particulate physical properties of nanometer size allows to distribute better usually in carrier, and the target purposes that does not hinder carrier is also given sufficient biocidal effect simultaneously.

The capsule of nano particle of the present invention and particulate can be usefully from the calcium hydroxide (Ca (OH) of many materials and hydration ₂, slaked lime or white lime) prepare, perhaps can place other basicity source in different physical forms, strengthen other performance that validity, life-span, transparency and specific product need.

By being used to prepare the technology of nano-sized particles arbitrarily, for example whole with referring to mode incorporate United States Patent (USP) 5,783,263 and United States Patent (USP) 5,585, the 020 described method of this paper into, can produce the useful thing nano particle of killing livestock.By routine test, can select only method.Prepare the method for useful particulate, be documented in, for example, United States Patent (USP) 5,922,253, United States Patent (USP) 6,022,564, United States Patent (USP) 6,471,995, United States Patent (USP) 6,395,304 and United States Patent (USP) 6,375,985.Such packing also is documented in, for example, and United States Patent (USP) 5,194,262, United States Patent (USP) 5,271,934 and United States Patent (USP) 4,874,611 (antiperspirant and insect bait).Similarly, at United States Patent (USP) 6,406,719, United States Patent (USP) 6,156,245, United States Patent (USP) 6,146,665, United States Patent (USP) 5,766,637 and United States Patent (USP) 6,156,245 in, the microencapsulation of many materials and reagent has been described.The relevant portion of these patents with regard to their described methods with referring to mode incorporate this paper into.

The Wellinghoff of the Southwest Research Institute of Texas San Antonio and other people have patented 5,914,126,6,194,481,6,410,765,5,922,776,5,888,528 and 5,668,185, they have described the dissimilar microparticle formulation that is applicable to calcium hydroxide of the present invention, with referring to mode incorporate this paper into.Encapsulation techniques also put down in writing with referring to mode incorporate in the United States Patent (USP) 6,291,537 (Ciminelli, etc.) of this paper.

Also can carry out the nanometer packing with the calcium hydroxide of Mierocrystalline cellulose-packing of the present invention, for example, as United States Patent (USP) 5,807,576 and United States Patent (USP) 5,547,748 is described, and the nano particle that obtains is added United States Patent (USP) 6,042,638, United States Patent (USP) 6,280,509 and United States Patent (USP) 6,231,650 cellulose paint strengthens the target capabilities of these thing coating of killing livestock.The relevant portion of these patents with referring to mode incorporate this paper into.

These different technologies can calcium hydroxide or other such biocidal material doped matrix material with packing in, plastics for example, wood pulp, and metal; Running stores are makeup for example, toothpaste, tooth powder, and thimerosal; With coating for example paint and polishing agent and permitted various other materials, comprise cotton, paper, rubber, nylon, timber, metal and results and the agricultural-food of results not, etc.

The biocidal effect that obtains preferably keeps activity 5-6 at least, and preferably effective to all types of microorganisms, as the patent of quoting confirmation in the past.Biocidal effect of the present invention preferably resembles United States Patent (USP) 6,042 at least, and 638, United States Patent (USP) 6,280,509 and the disclosed result of United States Patent (USP) 6,231,658 described calcium hydroxide coating be equally effective.

Have permanent outside surface as fruit product, encapsulated coating of the present invention and/or carrier are united the reception and registration to product external surfaces of basicity that calcium hydroxide is provided, prevention simultaneously or postpone to contact with atmosphere the carbonating of the calcium hydroxide that causes in fact.Kill livestock thing result and time length equals referenced patent United States Patent (USP) 6,042,638, United States Patent (USP) 6,280, and 509 and United States Patent (USP) 6,231, described in 650, expection reaches the degree that changeable material and mode satisfy these requirements.

But, think that product and coating with calcium hydroxide nano particle of the present invention are more effective and more lasting on the thing of killing livestock than disclosed coating in those patents.Can prevention or delay contact the calcium hydroxide carbonating that causes with ambient atmosphere, and use basicity except that calcium hydroxide to store the material of storehouse and cellulose layer coating material in addition and mode micro-capsule and nanometer packing calcium hydroxide, be variant of the present invention, and within the scope of the invention.Preferably, the present invention is nontoxic, and maintain be exposed to 100% carbonic acid gas ambient atmosphere (otherwise its can be in 1-2 days carbonating calcium hydroxide, make it can not be used as biocide) basicity of kill microorganisms effectively after 1 month.In another variant, the product of the present invention that obtains is kept its biocidal activity 5-6, even when in 100% carbonic acid gas ambient atmosphere, wearing out.

The particle of packing can be designed to, by triggering release with contacting of moisture, for example in makeup, at this moment body fluids can trigger the thing validity of killing livestock.In some preparation, preferably add wetting agent.A function of wetting agent is, promotes the reception and registration of the basicity of calcium hydroxide to the surface of product that obtains or coating, and making outside surface have is enough to kill the biocidal activity of most of microbe.

Although thoroughly do not understand the definite theory of effect of the present invention and effect, think that the active hydrogen calcium oxide of enough a large amount of packing is by the reception and registration of saturating property matrix to product or coating outside surface, can pass on enough high alkalinities, thereby the microorganism is here had biocidal effect.And because packing of the present invention can protect calcium hydroxide to avoid carbonating, the biocidal activity of the biocidal activity of calcium hydroxide and the product that obtains can prolong the useful time period.

The granular size of encapsulated particles, surface charge and composition have determined its performance, and can change according to the needs of target purposes.Having the nano particle of calcium hydroxide core or particulate can have and be designed for the surface that is adsorbed onto on the target thing surface (for example skin or other organic tissue).Can usefully wetting agent be mixed in such mixture, make basicity more easily be communicated to target thing surface.The preferred wetting agent of calcium hydroxide coating of the present invention is 15% glycerine (by weight).Other useful wetting agent is: vegetables oil, ammonium chloride, calcium chloride, sodium sulfate, Tai-Ace S 150, sodium-acetate, and salt hydrate.The hydrocarbon tackiness agent of the described calcium hydroxide coating of the present invention of wetting agent such as glycerine and ethylene glycol and parent patent is incompatible.The suitable wetting agent of organic radical coating comprises organic soluble poly aklylene glycol, and other.Propylene glycol and polypropylene glycol are useful wetting agents, but are not strong as glycerine.The design of wetting agent itself is well-known, especially for the those of ordinary skill of cosmetic industry.Cosmetic industry often uses wetting agent to keep high-caliber moisture at skin surface.But the purposes of the killing effect of the promotion calcium hydroxide of wetting agent is wonderful.

Another advantage of the calcium hydroxide system of some packing is, it may be opaque containing 100nm particulate goods, contains 60nm or more short grained goods can produce clarifying dispersed system.They are specially adapted to local healing and handle and makeup.In another embodiment, the calcium hydroxide of nanometer packing can be transparent, is used for being contained in transparent plastics.If the nano particle skin comprises hydrophobic material, nano particle can so that to product have in the presence of the water more lasting.This can be created in the product that still keeps their biocidal activity behind the water repeated washing.

The human early stage many soap that use are based on alkali lye.But the makeup industry usually can production high alkalinity soap now.A new purposes of the system system of killing livestock based on lime disclosed herein is high lime, high pH soap, its be used for especially when the thing soap of wishing to kill livestock can kill fungi, the situation of mould spores or other biology that is difficult to kill.Non-ionic type soap for example based on the soap of glycerine, in conjunction with the tensio-active agent and the calcium hydroxide of appropriate amount, can be produced useful soap bar, and it has about pH12 or basicity bigger, preferred pH12.4-12.5.Glycerine or similar substrates can prevent calcium hydroxide because contact and be neutralized with atmospheric carbon dioxide.Soap kill livestock the thing shelf-life thereby very long sustainable several years.When using soap, when promptly contacting also front and back friction with water, the thing of killing livestock that water and moist calcium hydroxide can provide this paper to discuss kills the required very high alkalescence of system, and this is enough to kill microorganisms, comprises spore.

Suppose, the described soap that contains enough calcium hydroxide can provide about pH12 or higher high alkalinity in use, can is used for when the end on duty cleaning by people such as die Postangestellter or medical personnel, with thorough killing bacteria and other biology, even comprise the spore that is difficult to kill, for example anthrax.Suppose the topical application of such soap, other surface and the surperficial disease down that can treat wart, acne, tinea pedis, fungi effectively and cause by the external microorganism that is difficult to kill.The emulsifiable paste of this purposes preferably can be applied to skin 7-10 days, although can use-testing change pH and time length.

Calcium hydroxide (a kind of attested and unique biocide) has unique wide spectrum and kills ability, and have good safety and nontoxic performance, be impregnated in the tackiness agent, when as partial coating, described tackiness agent can keep the oxyhydroxide performance for many years.The potential use of this coating is very huge, comprises all chamber internal surfaces that allergen and microorganism accumulate and breed in the above.White lime is nontoxic, so that it can per os take in, as the calcium source, recovering and being applied in the mouth during treatment cavity, is applied to fungi and virus infection, tinea unguium for example, and skin is superfluous, and wart, has surprising treatment benefit.Be reported that the staff who sucks dust can recover from TB, and it is used for the water that the purifying cholera is polluted in developing country.The purposes of its sterilization imported product also is well-known.

This ubiquitous mineral have the potentiality of the war that reverses the antagonism disease, and in this war, microorganism is preponderated, because they can evolve, suddenly change, and new form occurs along with burning rainforest, vulcanism and earthquake.

By reducing the concentration of water carrier in the BNA latex, can send based on the white lime product with micro-capsule form (by spraying drying BNA latex) or with gel or paste form, perhaps conduct is really water miscible, water is removable, partial antimicrobial agents.It also can be used as mouth wash shua or vaginal douche, eliminates local infection, otherwise can need dangerous and pharmacological agent pain.Solvable lime (liming) contains the calcium hydroxide of certain percentage (0.15%), but to the skin gentleness, then is strong sterilization medium for control bacterium, virus and fungi.This alkaline-earth metal white lime saturated solution has pH12.454, and qualitative is alkali, but is not the corrodibility mineral substance, does not resemble sodium, potassium and other alkali metal hydroxide.Compare with the alkali metal hydroxide of high-dissolvability, alkaline earth metal hydroxidess such as the calcium of low solubility, magnesium, barium are gentle alkali.

The liming flushing that per os is used can strengthen enamel, and promotes the formation and the regeneration of hydroxyapatite, destroys the unwanted bacteria that causes oral cavity infection simultaneously.

It is unique known meeting effectively destroy microorganisms, but to people and the seemingly benign biocide of substrate.When being applied to animal tissues rather than microorganism, can reverse the mechanism (enzyme denaturation and incapacitation) of attack micro organisms rapidly.

No matter white lime is water-soluble BNA or conduct slurry agent, paste or capsule, has the potentiality of rapid destruction of infectious microorganism.Monilial infection has become general, causes the part and the general disease of many forms.Verified, white lime can be removed wart, toe and pin fungi, skin is superfluous, and the erosion effect that can resist elegant jessamine, toxicodendron and poison sumac potentially by neutralizing a toxin, when being applied to ant, scorpion, jellyfish and wart as paste, the acid toxin (formic acid) that neutralizes stops that pain is bitten and sting.

The artificial tooth and the dental repair thing that comprise acrylic ester polymer can tolerate high-caliber lime as weighting agent, and secular antimicrobial protection is provided.Artificial tooth can if thoroughly do not clean, can continue overnight incubation from the swill culturing bacterium when waking.White lime can provide from continuous low-level leach of artificial tooth to mouth, and this is enough to suppress bacterium and goes down to posterity and grow.

By the gradually release of white lime in vascular system, can control but do not remove virus and bacteria levels, this allows immunity system to preponderate and win.The example of artificial tooth and dental repair thing is:

10-50 volume % calcium hydroxide (less than 45 microns) is mixed mutually with 50-90 volume % Acrylic Acid Monomer and promotor.1 or 2 second the time, when with the test of ambuside paper, solidified artificial tooth or restorer show surface p H11-12 on being applied to matrix.Up to now, do not observe the sign of the oral stimulation of the acrylate that contains lime that per os uses.

BNA-W (BNA of water-soluble form) is applied to the superfluous or wart of skin every day, can in about 2 weeks, removes the two safely, to not influence of perienchyma.

BAN-L is applied to the fungi tinea unguium, and continues 7 days, use solvent (dimethylbenzene or acetone) to remove then, can destroy fungi, and recover natural colour.If in 1 week, be not effective, can repeated application BNA latex, reach 2-3 week, remove in the time of must not or taking a shower in daily shower.Removal subsequently can realize by the acetone or the dimethylbenzene of being free from side effects.

0.1% suspension of calcium hydroxide in distilled water provides oral cavity and vaginadouche agent, is used for break virus, fungi, and bacterial cultures.Be used for the water irrigation in oral cavity and/or be used for the oral cavity and the dilution vinegar irrigation of vaginal douche is optional.

In a word, the present invention can be summarized as, and identification calcium hydroxide new and effective purposes suppress carrier by carbonic acid gas and mix and be used for oral cavity and pharmaceutical usage, no matter microencapsulation still to send in gel or paste form or the dilute aqueous solution.As mouth wass, lime can provide safe, effective and useful destruction to cause the method for microorganism in infection or tooth hole.In the slurry agent of Mierocrystalline cellulose improvement, send and be applied to genital infection (vagina and other places), carry out the flushing of vinegar lavation and water then, lime can provide the possibility of controlling and destroy bacterium, fungi and virus infection effectively, otherwise needs more radical and processing pain.White lime can provide many health advantages in food-processing and packing, and can greatly improve the health and the environment in the zone that faces microorganism growth and pollution threat usually.

By adding the BNA or the lime of appropriate amount, the prosthetic implant that comprises conventional acrylate copolymer is worked preferably.Stable slowly leaching during calcium hydroxide is organized towards periphery can provide the barrier of microorganism growth, especially after operation soon, and supply with the calcium of serum key continuously, to alleviate bone loss and extra-nutrition source.Such prosthese is not to be limited to partially, can comprise All Ranges, mandibular bone, pelvis, vertebra of health etc.

Those skilled in the art can understand that the material beyond the Mierocrystalline cellulose can satisfy these requirements.Those skilled in the art can understand that the technology described in these patents can easily be used to produce the measurable benefit of described variant.When with the described knowledge of these patents when combined, think that the disclosed content of the application can make those skilled in the art understand how to prepare without undue experimentation biocidal packing or not the calcium hydroxide nano particle and the particulate of packing.

Utilizing the present invention to make some product when for example dental filling, tooth powder and topical ointment have biocidal properties, can utilize the existing conventional prescription, and mix the calcium hydroxide particle of nanometer size therein, present in an amount at least sufficient to make their to produce the biocidal activity that prolongs.By routine test and the known accelerated weathering test of test composition, can easily determine the optimum quantity of any particular composition to the effect of known test microorganism.Be used for these purposes with test coating relevant above-mentioned existing patent, other guidance is provided.

As other embodiment, the topical ointment that the nanometer size calcium hydroxide particle that has wherein added different levels is produced biocidal activity places container, for example conventional jar or the pipeline that is used for such purpose.Then, they are coated on the testing surface, reach the thickness of conventional non-kill livestock thing ointment and the use of known test microorganism, to determine to use the best biocidal amount of nanometer size calcium hydroxide.These jars and pipeline also can carry out accelerated weathering test, and routine test as mentioned above, and the biocidal activity level that can keep hope with definite composition is how long.Obviously, these identical tests can be used for determining the operating restraint of nanometer size and the best size of all biocidal compositions of the present invention.An aspect of present embodiment comprises above-mentioned kill livestock thing encapsulated particles and method.In a preferred embodiment, herein disclosed is biocidal composition, it contains the effective white lime nano particle of the thing significant quantity of killing livestock.In addition, herein disclosed is the method for preparing biocidal composition, described biocidal composition comprises the white lime nano particle of the amount that can bring into play biocidal activity effectively.

Embodiment 19

Other embodiment

Calcium hydroxide material of the present invention can be included in stain remover, liquid soap, toothpaste, shampoo and the skin cream, and wherein their topical application on health can be killed the microorganism at this place.

In agricultural, mould can be caused a large amount of losses of the crop of results.A concrete useful purposes is the sealing area of the crop of preservation results.For example, corn and other cereal often are deposited in the silo of sealing, wherein deflate and replace with nitrogen.The crop of protection results of the present invention avoids mould, fungi and other method of microorganism and is, along with as entering silo through the tunnel, sprays the mist of lime and water to crop.Because nitrogen has substituted the air that contains carbonic acid gas, lime can keep the biocidal activity time enough, to hinder mould, fungi and other propagation of undesirable microorganism in the crop of preservation.

The another kind of purposes of coating of the present invention is to spray their thin layer on the crop of field, to suppress the microorganism insect.Thin cellulose coating of the present invention can be prevented lime and carbonic acid gas chemical combination, thus the basicity of protection lime.

Environmental law requires to remedy the room and the buildings of lead base paint now, and for health benefit, especially children's health will make its stabilization or removal.Its reason is that the dust of lead base paint particle can float in the air, be inhaled into, and child can lick the painted surface of stinging sweet taste.Remedying of lead base paint is complicated, hostile environment and health, and be expensive proposal.Requirement is left all refuses in the dangerous refuse rubbish in.Use Caliwel to cover lead base paint, can sealing face, and can also with any free lead reaction, it is changed into insoluble compound calcium plumbate, become nontoxic surface subsequently.

Although described the present invention in conjunction with preferred embodiment, be not intended to limit the scope of the present invention to described specific form, but on the contrary, be intended to contain such replacement scheme, modification and the equivalent that can be included in the definite spirit and scope of the invention of appended claims.

Sum up

The description of test 1.Use dilution test-10 parts of Salmonella choleraesuls of the same form and Pseudomonas aeruginosa are exposed to the test materials 10 minutes that BNA-handled; 10 parts of streptococcus aureuses of the same form are exposed 20 minutes.The result of test 1 after 10 minutes, has eliminated Salmonellas and pseudomonas, 10/10 positive carrier.After 20 minutes, eliminated staphylococcus, 10/10 positive carrier.

The description of test 2.Streptococcus aureus and Pseudomonas aeruginosa inoculum wet and that do are exposed to BNA1 hour (every kind same form 10 parts).The result of test 2.Staphylococcus;-99.91% decreased average of doing;-99.93% decreased average that wets; Pseudomonas ,-99.99% dried and wet decreased average.

The description of test 3.BNA is applied to plastic sheet, and tests the ability of 3 kinds of viruses of its deactivation (poliovirus 1 type, human herpesvirus 1's type and haemadsorption virus 1); Be exposed to BNA 0,5, after 10,15,30 and 60 minutes, collect viral sample, and the amount of the infectious virus of test existence.The result of test 3, poliovirus-deactivation in 15 minutes.Herpes virus hominis-deactivation in 10 minutes (deactivation 90% in 5 minutes).Parainfluenza virus-deactivation in 60 minutes.

The description of test 4.3 deal boards that scribble BNA in all sides are exposed to 3 kinds of fungies (aureobasidium pullulans, aspergillus and Penicillium notatum), and 4 weeks of incubation.The result of test 4.2 in 3 blocks of plates do not have fungal growth.One has the fungal growth that separates spot.

The description of test 5.3 filter paper samples that scribble BNA are exposed to Pseudomonas aeruginosa, and 4 weeks of incubation.Test 5 result, on each sample or below, do not see bacterial growth.

The description of test 6.Paper loading plate sample coating BNA, and be exposed to Stachybotraschartarum, incubation 28 days.On the coating side direction and the coating side direction under the incubation sample.Test 6 result, do not observe the fungal growth of any kind of, even the sample under those coating side direction is as the same.

On-the-spot efficiency assay.Accelerated weathering test has confirmed that effective antimicrobial surface is active in 6 years.It is active that at least 60% biocide keeps, and keeps original pH simultaneously.For example, expose after 7 days, 78.1% remaining biocide is arranged; Expose after 1 month, 77.5% remaining biocide is arranged; Expose after 6 months, 71.3% remaining biocide is arranged; Expose after 10 months, 70.3% remaining biocide is arranged; Expose after 42 months, 69.8% remaining biocide is arranged.In addition studies confirm that validity to subtilis and anthrax.

Citing document

Below document especially incorporating this paper into referring to mode, its degree is, they provide on the exemplary program of replenishing content described herein or other details.

U.S. patent documents

License to the United States Patent (USP) series number 6,280,509 of the title of Mallow August 28 calendar year 2001 for " Biocidal CoatingCompositions and Method "

License to the United States Patent (USP) series number 6,231,650 of the title of Mallow etc. May 15 calendar year 2001 for " Biocidal CoatingComposition "

Licensed to the United States Patent (USP) series number 6,042,638 of the title of Mallow etc. on March 28th, 2000 for " Biocidal CoatingComposition "

What submitted on June 1st, 2004 is contriver, the title U.S. Patent application 10/476,732 for " Stabilized Biocidal Coating Composition and Method " with Mallow etc.

Claims (34)

1. have active heating and ventilation and air-conditioning (" the HVAC ") system of killing bacteria spore, virus and fungi, it comprises:

Scribble the HVAC system component of biocidal composition at least in part, described composition comprises:

(i) white lime;

(ii) soluble binding agent polymeric blends; With

(iii) wetting agent;

Wherein said white lime, soluble binding agent polymeric blends and wetting agent are blended in based in organic or the solvent systems based on water, and the latter is used to apply the HVAC system component; The ratio of lime and soluble binding agent polymkeric substance is about 1: 1 to about 1: 3, and wetting agent accounts for the 15.5%-25% (weight %) of chemical coating; But and described chemical coating permeate water, the impermeable carbonic acid gas.

2. the HVAC system component of claim 1, wherein said HVAC system component with the thing coating of killing livestock comprises: return air chamber; New air chamber mixing cassette air chamber; Coil chamber; Fan housing; Humid cabinet; Remove moist chamber; The spraying eradicator; Filter hood; Window shutter; HVAC air feed pipe and backwind tube; The air door adjustment sheet; Vapor pipe; Air door; Baffle plate; Strainer; Fan shield; With wall and floor board ventilation plant trave sheet.

3. the HVAC system component of claim 1, the activity of wherein said killing bacteria spore, virus and fungi can effectively be resisted: anthrax spores; Pseudomonas aeruginosa; Streptococcus aureus; Salmonella choleraesuls; Intestinal bacteria; Streptococcus faccialis; Klebsiella Pneumoniae; Legionella pneumophilia; Mutual lattice chain lattice spore; Aspergillus; Cladosporium; Aureobasidium pullulans; Penicillium funicullatum; Stachybotras chartarum; Influenza A2 type; Rhinovirus; Rotavirus; Adenovirus 2 types; Respiratory syncytial virus; Hepatitis; Poliovirus I type; Herpes virus hominis I type; Parainfluenza virus III type.

4. the HVAC system component of claim 1, wherein said soluble binding agent polymeric blends comprises: the polymkeric substance of the cellulose-derived of water-soluble poly alkylene oxide and hydroxylated or carboxylation, salt and cellulosic carboxyalkyl-derivative with cellulosic acid, carboxyethyl cellulose, carboxymethyl cellulose and carboxyl hydroxylated cellulose.

5. the HVAC system component of claim 1, wherein said soluble binding agent polymeric blends comprises: the polymkeric substance of organic soluble cellulose-derived, alkylcellulose, ether of cellulose, cellulose ester, cellulose acetate, cellulose butylate, ethyl cellulose and organic soluble polyoxyethylene glycol.

6. the HVAC system component of claim 1, wherein said wetting agent is water miscible, and comprises: glycerine; Vegetables oil, ammonium chloride, calcium chloride, sodium sulfate, Tai-Ace S 150, sodium-acetate, salt hydrate.

7. the HVAC system component of claim 1, wherein said wetting agent comprises: polyalkylene glycol, propylene glycol and polypropylene glycol.

8. the HVAC system component of claim 1 also comprises about 35% to about 40% latex.

9. have the active clothes of killing bacteria spore, virus and fungi, it comprises:

Described clothes have first and second, and wherein said first face scribbles biocidal composition in fact, and described composition comprises:

(i) white lime;

(ii) soluble binding agent polymeric blends; With

(iii) wetting agent;

Wherein said white lime, soluble binding agent polymeric blends and wetting agent are blended in based in organic or the solvent systems based on water, and the latter is used to apply clothes; The ratio of lime and soluble binding agent polymkeric substance is about 1: 1 to about 1: 3, and wetting agent accounts for the 15.5%-25% (weight %) of chemical coating; But and described chemical coating permeate water, the impermeable carbonic acid gas; And second face of wherein said clothes does not have described biocidal composition in fact.

10. the clothes of claim 9, wherein said clothes with the thing coating of killing livestock comprise: apron, trousers, shirt, jacket, coat, robe, gloves, cap, shoes, boots, and socks.

11. the clothes of claim 9, wherein said first bread contains the outside of clothes, and described second bread contains the inner face of clothes.

12. the clothes of claim 9, the activity of wherein said killing bacteria spore, virus and fungi can effectively be resisted: anthrax spores; Pseudomonas aeruginosa; Streptococcus aureus; Salmonella choleraesuls; Intestinal bacteria; Streptococcus faccialis; Klebsiella Pneumoniae; Legionella pneumophilia; Mutual lattice chain lattice spore; Aspergillus; Cladosporium; Aureobasidium pullulans; Penicilliumfunicullatum; Stachybotras chartarum; Influenza A2 type; Rhinovirus; Rotavirus; Adenovirus 2 types; Respiratory syncytial virus; Hepatitis; Poliovirus I type; Herpes virus hominis I type; Parainfluenza virus III type.

13. the clothes of claim 9, wherein said soluble binding agent polymeric blends comprises: the polymkeric substance of the cellulose-derived of water-soluble poly alkylene oxide and hydroxylated or carboxylation, salt and cellulosic carboxyalkyl-derivative with cellulosic acid, carboxyethyl cellulose, carboxymethyl cellulose and carboxyl hydroxylated cellulose.

14. the clothes of claim 9, wherein said soluble binding agent polymeric blends comprises: the polymkeric substance of organic soluble cellulose-derived, alkylcellulose, ether of cellulose, cellulose ester, cellulose acetate, cellulose butylate, ethyl cellulose and organic soluble polyoxyethylene glycol.

15. the clothes of claim 9, wherein said wetting agent is water miscible, and comprises: glycerine; Vegetables oil, ammonium chloride, calcium chloride, sodium sulfate, Tai-Ace S 150, sodium-acetate, salt hydrate.

16. the clothes of claim 9, wherein said wetting agent comprises: polyalkylene glycol, propylene glycol and polypropylene glycol.

17. the clothes of claim 9 also comprise about 35% to about 40% latex.

18. have the active ward article of killing bacteria spore, virus and fungi, it comprises:

Scribble the ward article of biocidal composition, described composition comprises:

(i) white lime;

(ii) soluble binding agent polymeric blends; With

(iii) wetting agent;

Wherein said white lime, soluble binding agent polymeric blends and wetting agent are blended in based in organic or the solvent systems based on water, and the latter is used to apply the ward article; The ratio of lime and soluble binding agent polymkeric substance is about 1: 1 to about 1: 3, and wetting agent accounts for the 15.5%-25% (weight %) of chemical coating; But and described chemical coating permeate water, the impermeable carbonic acid gas, and wherein said ward article comprise: handle; Medicine equipment; Worktable; Computor-keyboard; The plastic cover of computor-keyboard; The secret curtain; Window-blind; Curtain; Hospital furniture; Or gatekeeper's equipment.

19. the ward article of claim 18, the activity of wherein said killing bacteria spore, virus and fungi can effectively be resisted: anthrax spores; Pseudomonas aeruginosa; Streptococcus aureus; Salmonella choleraesuls; Intestinal bacteria; Streptococcus faccialis; Klebsiella Pneumoniae; Legionella pneumophilia; Mutual lattice chain lattice spore; Aspergillus; Cladosporium; Aureobasidium pullulans; Penicillium funicullatum; Stachybotras chartarum; Influenza A2 type; Rhinovirus; Rotavirus; Adenovirus 2 types; Respiratory syncytial virus; Hepatitis; Poliovirus I type; Herpes virus hominis I type; Parainfluenza virus III type.

20. the ward article of claim 18, wherein said soluble binding agent polymeric blends comprises: the polymkeric substance of organic soluble cellulose-derived, alkylcellulose, ether of cellulose, cellulose ester, cellulose acetate, cellulose butylate, ethyl cellulose and organic soluble polyoxyethylene glycol.

21. the ward article of claim 18, wherein said wetting agent is water miscible, and comprises: glycerine; Vegetables oil, ammonium chloride, calcium chloride, sodium sulfate, Tai-Ace S 150, sodium-acetate, salt hydrate.

22. the ward article of claim 18, wherein said wetting agent comprises: polyalkylene glycol, propylene glycol and polypropylene glycol.

23. the ward article of claim 18 also comprise about 35% to about 40% latex.

24. have the active food storage container of killing bacteria spore, virus and fungi, it comprises:

Scribble the food storage container of biocidal composition, described composition comprises:

(i) white lime;

(ii) soluble binding agent polymeric blends; With

(iii) wetting agent;

Wherein said white lime, soluble binding agent polymeric blends and wetting agent are blended in based in organic or the solvent systems based on water, and the latter is used to apply the food storage container; The ratio of lime and soluble binding agent polymkeric substance is about 1: 1 to about 1: 3, and wetting agent accounts for the 15.5%-25% (weight %) of chemical coating; But and described chemical coating permeate water, the impermeable carbonic acid gas, and wherein said food storage container comprises: plastic containers, metal vessel, plastic pallet, metal tray, paper bag, or plastics bag.

25. the food storage container of claim 24, the activity of wherein said killing bacteria spore, virus and fungi can effectively be resisted: anthrax spores; Pseudomonas aeruginosa; Streptococcus aureus; Salmonella choleraesuls; Intestinal bacteria; Streptococcus faccialis; Klebsiella Pneumoniae; Legionella pneumophilia; Mutual lattice chain lattice spore; Aspergillus; Cladosporium; Aureobasidium pullulans; Penicillium funicullatum; Stachybotras chartarum; Influenza A2 type; Rhinovirus; Rotavirus; Adenovirus 2 types; Respiratory syncytial virus; Hepatitis; Poliovirus I type, herpes virus hominis I type; Parainfluenza virus III type.

26. the food storage container of claim 24, wherein said soluble binding agent polymeric blends comprises: the polymkeric substance of organic soluble cellulose-derived, alkylcellulose, ether of cellulose, cellulose ester, cellulose acetate, cellulose butylate, ethyl cellulose and organic soluble polyoxyethylene glycol.

27. the food storage container of claim 24, wherein said wetting agent is water miscible, and comprises: glycerine; Vegetables oil, ammonium chloride, calcium chloride, sodium sulfate, Tai-Ace S 150, sodium-acetate, salt hydrate.

28. the food storage container of claim 21, wherein said wetting agent comprises: polyalkylene glycol, propylene glycol and polypropylene glycol.

29. the food storage container of claim 21 also comprises about 35% to about 40% latex.

30. have the active composition of killing bacteria spore, virus and fungi, it comprises:

(i) white lime;

(ii) soluble binding agent polymeric blends;

(iii) wetting agent;

(iv) hydrogen peroxide; With

(v) colloidal silver;

Wherein said white lime, soluble binding agent polymeric blends, wetting agent, hydrogen peroxide and colloidal silver are blended in based in organic or the solvent systems based on water, and the latter is as chemical coating; The ratio of lime and soluble binding agent polymkeric substance is about 1: 1 to about 1: 3, and wetting agent accounts for the 15.5%-25% (weight %) of chemical coating; But and described chemical coating permeate water, and impermeable carbonic acid gas basically.

31. have the active composition of killing bacteria spore, virus and fungi, it comprises:

(i) white lime;

(ii) soluble binding agent polymeric blends; With

(iii) foam carrier;

Wherein said white lime, soluble binding agent polymeric blends and foam carrier are blended in the solvent systems based on water, and the latter is as the foam stain remover; The ratio of lime and soluble binding agent polymkeric substance is about 1: 1 to about 1: 3, and described foam stain remover impermeable carbonic acid gas basically.

32. the method for microbial spores, virus or fungi content in the minimizing room air, it comprises:

By having the strainer or the baffle plate circulation room air of the thing chemistry coating of killing livestock, the described thing coating of killing livestock comprises:

(i) white lime;

(ii) soluble binding agent polymeric blends; With

(iii) wetting agent;

Wherein said white lime, soluble binding agent polymeric blends and wetting agent are blended in based in organic or the solvent systems based on water, and the latter is used to apply strainer or baffle plate; The ratio of lime and soluble binding agent polymkeric substance is about 1: 1 to about 1: 3, and wetting agent accounts for the 15.5%-25% (weight %) of chemical coating; But and described chemical coating permeate water, and impermeable carbonic acid gas basically.

33. kill the method for termite in the tree, it comprises:

Have the base portion of the tree of termite with the thing coating brushing of killing livestock, the described thing coating of killing livestock comprises:

(i) white lime;

(ii) soluble binding agent polymeric blends; With

(iii) wetting agent;

Wherein said white lime, soluble binding agent polymeric blends and wetting agent are blended in based in organic or the solvent systems based on water, and the latter is used for brushing tree base portion; The ratio of lime and soluble binding agent polymkeric substance is about 1: 1 to about 1: 3, and described wetting agent account for chemical coating about 0% to about 25% (weight %); But and described chemical coating permeate water, and impermeable carbonic acid gas basically.

34. prepare the method for calcium plumbate from lead base coating, it comprises:

Cover lead base coating with the thing coating of killing livestock, the described thing coating of killing livestock comprises:

(i) white lime;

(ii) soluble binding agent polymeric blends; With

(iii) wetting agent;

Wherein said white lime, soluble binding agent polymeric blends and wetting agent are blended in based in organic or the solvent systems based on water, and the latter is used to apply lead base coating; The ratio of lime and soluble binding agent polymkeric substance is about 1: 1 to about 1: 3, and described wetting agent account for the thing coating of killing livestock about 0% to about 25% (weight %); But and the described thing coating permeate water of killing livestock, and impermeable carbonic acid gas basically.

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