CN101091816A - Device and method for raising permeability of preparation on skin of living body - Google Patents
Device and method for raising permeability of preparation on skin of living body Download PDFInfo
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- CN101091816A CN101091816A CN 200610082898 CN200610082898A CN101091816A CN 101091816 A CN101091816 A CN 101091816A CN 200610082898 CN200610082898 CN 200610082898 CN 200610082898 A CN200610082898 A CN 200610082898A CN 101091816 A CN101091816 A CN 101091816A
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Abstract
The present invention relates to a method capable of utilizing wireless radio-frequency control chip to raise permeability of preparation to vital skin. Said method is characterized by that one or several IC chips capable of receiving wireless radio-frequency can be inlaid in a soft material film, and can be used for receiving wireless radio-frequency signal and energy sent out by one or several wireless controller so as to control said one or several chips and make them produce at least one kind of electric current, electrophoresis, heat source and ultrasonic wave so as to make the components contained in said preparation be permeated into vital skin interior. Said invention also relates to a soft material film for above-mentioned method.
Description
Technical field
The present invention relates to utilize less radio-frequency control IC chip to improve preparation to the infiltrative device and method of skin of living body.
Background technology
The interesting research of known industry Noninvasive, painless new technique, effective ingredient or preparation are passed through skin absorbs, reach aesthetic health care or medical effect, and can reduce the puzzlement of oral and injectable drug and produce underdosage or too much problem, multiple technologies come into question.Utilize electrophoresis method can change the permeability of skin, make preparation be easy to infiltrate sweat gland, sebaceous gland and iuntercellular lipid on the normal or impaired skin of living body, known electrophoresis method can strengthen the absorption (Glass of local skin to ion component or preparation, J.M.et al., Int.J.Dermatol.19,519 (1980); Russo J., Am.J.Hosp.Pharm.37,843 (1980); Gangarosa, L.P.etal., J.Pharmacol.Exp.Ther.212,377 (1980); Kwon, B.S.et al., J.Infect.Dis.140,1014 (1979); Hill, J.M.et al., Ann.N.Y.Acad.Sci.284,604 (1977) and Tannebaum, M.Phys.Ther.60,792 (1980)).United States Patent (USP) the 4th, 474 in 1984, discloses a kind of skin electrophoresis apparatus No. 570.Utilize the cell in the galvanic stimulation culture dish, proved and can suppress staphylococcus aureus growth, and think that galvanism can suppress the growth of antibacterial on the wound (Merriman, H.L., et al., JRRD Vol 41, p.139-146,2004).On the other hand, ultrasound wave is known can increase the epiderm skin absorption and stimulate cutin (Horny Layer) cell to disperse.Research worker utilizes low-frequency ultrasonic waves to cooperate medicine to be applied to treat the alopecia of speckle type, melanin speckle (Melasma) and day sunburn (Solar Lentigo) (Santoianni, P., et al., Dermatology Online Journal 10 (2) 24,2004).And utilize low-frequency ultrasonic waves transdermal penetration device, reach whiten, the effect (TaiWan, China I220386 patent) of reduce wrinkle, grease removal and treatment tinea pedis.In zoopery, prove that also the low frequency ultrasound wave energy strengthens topical remedy and absorbs (Singer, A.J., Church, on the A., McClain, SA Academic EmergencyMedicine, Vol 5,3 5-40,1998 (Society for Academic Emergency Medicine publication)).Research worker finds, promoting heat also can increase the permeability (Hull, W., The Journal ofApplied Research, 2002) of skin to liquid circulation and blood vessel wall in the dissolubility of the absorption of medicine, medicine, the body.
Known present use electric current and electrophoresis normally are connected to first electrode or active electrode by the outfan with continuous direct current generator or pulse direct current generator, and be connected to second electrode or less important electrode, wherein this first electrode or active electrode are made up of metallic plate or conductive materials, and it is coated with the moisture film through the tool porous material of dipping preparation aqueous solution.Therefore, known this method is very inconvenient in the use, thereby has limited and used popularizing and development of this method local application medicament, and only could use in hospital or professional place.
The above-mentioned known devices that is used for skin generation electric current, electrophoresis, thermal source and ultrasound wave all is the non-wireless means that the alternating-current power supply supply line is arranged, and in carrier, be provided with power supply or battery, user for non-wireless means that the alternating-current power supply supply line is arranged, the shortcoming that poor mobility is arranged, and part system action need other people auxiliary just can finish.In addition, United States Patent (USP) the 4th, 474, No. 570 and U.S. Patent Application Publication disclose a kind of known devices of utilizing the control of alternating-current power supply supply line for No. 2003/0023187, and it is inconvenient to be applied to each position of skin of living body.
Summary of the invention
The objective of the invention is to utilize less radio-frequency control IC chip to overcome above-mentioned known devices inconvenience in the use, by in soft material film, embedding one or more IC chips that receive this less radio-frequency that have, control this IC chip to receive radio frequency signal that one or more wireless controller sent and energy and produce at least a in electric current, electrophoresis, thermal source and the ultrasound wave.User can be in the state of daily routines, and promptly the IC chip of controlling in the soft material film that places on the skin of living body by this wireless controller of ease of Use produces at least a of electric current, electrophoresis, thermal source and ultrasound wave.
Description of drawings
Fig. 1 for the IC chip in the soft material film of the present invention through the radio frequency signal that wireless controller sent and the sketch map of energy control.
Fig. 2 embeds the sketch map of IC chip for soft material film of the present invention.
Fig. 3 is for showing the IC chip reception signal that wireless controller transmitted and the sketch map of energy.
The specific embodiment
The invention provides a kind of less radio-frequency control IC chip that utilizes to promote the method for preparation to percutaneous permeability, this method is included in and embeds one or more IC chips that receive this less radio-frequency that have in the soft material film, control this IC chip to receive radio frequency signal that one or more wireless controller sent and energy and produce at least a in electric current, electrophoresis, thermal source and the ultrasound wave, thereby the said preparation ingredient is infiltrated in the skin.
In addition, the present invention relates to a kind of soft material film of utilizing less radio-frequency control IC chip, this soft material film mainly is made of the soft material that contains preparation, it comprises one or more IC chips with this less radio-frequency of reception and is embedded in this soft material film, control IC chip in this soft material film to receive radio frequency signal that one or more wireless controller sent and energy and make it produce at least a in electric current, electrophoresis, thermal source and the ultrasound wave, thereby branch that said preparation synthesizes is infiltrated in the skin of living body.
This soft material film can be facial film, skin and applies film, percutaneous absorption adhesive patch or adhesive bandage etc., its be through the dipping preparation in moisture film wherein, said preparation is a fluid preparation, it comprises the composition of at least a chemical substance or natural material.After IC chip in this soft material film receives radio frequency signal and energy, produce at least a in electric current, electrophoresis, thermal source and the ultrasound wave by this IC chip emulation, thereby said preparation is infiltrated in the skin of living body, also can be used for controlling dispenser dosage.
IC chip in this soft material film can be controlled by wireless controller, this wireless controller is the electronic installation with power supply and IC chip, IC chip on the may command soft material film produces at least a in electric current, electrophoresis, thermal source and the ultrasound wave, and this electronic installation can comprise the electronic-controlled installation of mobile phone, personal computer, PDA and customization etc.
As shown in Figure 1, this soft material film 4 is the thin film through the preparation impregnation process, and said preparation is a fluid preparation, and it comprises the composition of at least a chemical substance or natural material.Have a plurality of IC chips 1 in this soft material film 4 receiving this radio frequency signal 2 and energy, and further produce at least a in electric current, electrophoresis, thermal source and the ultrasound wave, infiltrate in the skin of living body thereby strengthened said preparation.
The sketch map of Fig. 2 shows to embed in the soft material film 4 of the present invention to have the IC chip 1 that receives less radio-frequency, does not wherein have the power supply supply to be wired on this film, and it can be driving component or passive component.
The sketch map of Fig. 3 shows that the present invention is made up of IC chip 1 in wireless controller 3 and the soft material film.The just so-called responder of IC chip 1 (Transponder), it is made up of two parts.Its operating principle is, by the radio frequency signal of wireless controller 3 emission one characteristic frequency and energy 2 to film end responder, induction mode is inductive (Inductive Coupling) or backscatter coupling (Backscatter Coupling), it is used for the circuit in the drive membrane end IC chip 1, and built-in command is sent execution, IC chip 1 applied current system received successively and understood this instruction this moment, produced at least a in electric current, electrophoresis, thermal source and the ultrasound wave.This passive type IC chip 1 will be received from signal and the energy that wireless controller 3 is transmitted, and convert the required electric energy of IC chip 1 internal circuit operation to, not need external battery; This wireless controller 3 transmits and energy through antenna.
By above-mentioned explanation, as can be known the present invention as described below each side all be better than one type of prior art syringe:
| One type of prior art syringe | The present invention | |
| Structure | Wired | Wireless |
| The IC chip | Do not have | Have |
| Mobility | Inconvenient | Convenient |
| Control end | Large-scale machine | The electronic-controlled installation of mobile phone, PDA, customization etc. |
The present invention can make various specific examples not leaving under spirit of the present invention and the basic feature.Scope of the present invention is limited by the claim scope of enclosing, and is limited by above-mentioned explanation, and all should be contained among the present invention with the variation that claim scope meaning equates.
Claims (11)
1. one kind is utilized less radio-frequency control IC chip to improve preparation to the infiltrative method of skin of living body, this method comprises: embed one or more IC chips that receive this less radio-frequency that have in soft material film, control this IC chip to receive radio frequency signal that one or more wireless controller sent and energy and produce at least a in electric current, electrophoresis, thermal source and the ultrasound wave, thereby the said preparation ingredient is infiltrated in the skin of living body.
2. the method for claim 1, wherein said preparation is a fluid preparation, and it comprises the composition of at least a chemical substance or natural material.
3. the method for claim 1, wherein the IC chip in this soft material film receives and produces at least a in electric current, electrophoresis, thermal source and the ultrasound wave behind this radio frequency signal and the energy.
4. method as claimed in claim 3, wherein, the IC chip in this soft material film comprises driving component or passive component, and it drives at least a in electric current, electrophoresis, thermal source and the ultrasound wave produced, also can be used for controlling dispenser dosage.
5. the method for claim 1, wherein this wireless controller is the electronic installation with power supply and IC chip, and IC chip on this soft material film of may command produces at least a in electric current, electrophoresis, thermal source and the ultrasound wave.
6. the method for claim 1, wherein this soft material film is that facial film, skin apply film, percutaneous absorption adhesive patch or adhesive bandage.
7. soft material film of utilizing less radio-frequency control IC chip, this soft material film mainly is made of the soft material that contains preparation, it comprises one or more IC chips with this less radio-frequency of reception and is embedded in this soft material film, control IC chip in this soft material film to receive radio frequency signal that one or more wireless controller sent and energy and make it produce at least a in electric current, electrophoresis, thermal source and the ultrasound wave, thereby the said preparation ingredient is infiltrated in the skin.
8. soft material film as claimed in claim 7, wherein, said preparation is a fluid preparation, it comprises the composition of at least a chemical substance or natural material.
9. soft material film as claimed in claim 7, wherein, the IC chip in this film receives and produces at least a in electric current, electrophoresis, thermal source and the ultrasound wave behind this radio frequency signal and the energy.
10. soft material film as claimed in claim 7, wherein, this wireless controller is the electronic installation with power supply and IC chip, IC chip on the soft material film on this skin of living body of may command produces at least a in electric current, electrophoresis, thermal source and the ultrasound wave.
11. soft material film as claimed in claim 7, wherein, this IC chip needs battery or does not need battery.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100828987A CN101091816B (en) | 2006-06-19 | 2006-06-19 | Device and method for raising permeability of preparation on skin of living body |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2006100828987A CN101091816B (en) | 2006-06-19 | 2006-06-19 | Device and method for raising permeability of preparation on skin of living body |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101091816A true CN101091816A (en) | 2007-12-26 |
| CN101091816B CN101091816B (en) | 2010-06-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2006100828987A Expired - Fee Related CN101091816B (en) | 2006-06-19 | 2006-06-19 | Device and method for raising permeability of preparation on skin of living body |
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| Country | Link |
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| CN (1) | CN101091816B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107613853A (en) * | 2015-01-23 | 2018-01-19 | 马尔西奥·马克·阿布雷乌 | Apparatus and method for skin treatment |
| CN112933389A (en) * | 2020-11-05 | 2021-06-11 | 沈阳中康医疗科技有限公司 | Portable ultrasonic direct current electric pulse iontophoresis therapeutic instrument |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5810066A (en) * | 1981-07-10 | 1983-01-20 | 株式会社アドバンス | Plaster structure for ion tofuorese |
| JP4154016B2 (en) * | 1997-12-30 | 2008-09-24 | 久光製薬株式会社 | Iontophoresis device and assembly method thereof |
| CA2464949A1 (en) * | 2001-10-24 | 2003-05-01 | Daniela Mavor | Device and method for controlled delivery of active substance into the skin |
-
2006
- 2006-06-19 CN CN2006100828987A patent/CN101091816B/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107613853A (en) * | 2015-01-23 | 2018-01-19 | 马尔西奥·马克·阿布雷乌 | Apparatus and method for skin treatment |
| CN112933389A (en) * | 2020-11-05 | 2021-06-11 | 沈阳中康医疗科技有限公司 | Portable ultrasonic direct current electric pulse iontophoresis therapeutic instrument |
| CN112933389B (en) * | 2020-11-05 | 2022-11-01 | 沈阳中康医疗科技有限公司 | Portable ultrasonic direct current electric pulse iontophoresis therapeutic instrument |
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| Publication number | Publication date |
|---|---|
| CN101091816B (en) | 2010-06-16 |
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Granted publication date: 20100616 Termination date: 20180619 |