CN101084205A - 作为5ht2c受体调节剂以治疗与其相关病症的n－联芳基和n－芳基杂芳基哌嗪衍生物 - Google Patents

作为5ht2c受体调节剂以治疗与其相关病症的n－联芳基和n－芳基杂芳基哌嗪衍生物 Download PDF

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Publication number
CN101084205A
CN101084205A CNA2005800424116A CN200580042411A CN101084205A CN 101084205 A CN101084205 A CN 101084205A CN A2005800424116 A CNA2005800424116 A CN A2005800424116A CN 200580042411 A CN200580042411 A CN 200580042411A CN 101084205 A CN101084205 A CN 101084205A
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Prior art keywords
piperazine
fluoro
arbitrary
compound
biphenyl
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CNA2005800424116A
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Chinese (zh)
Inventor
布赖恩·M·史密斯
文森特·J·尚托拉
林丽奈
贾森·B·伊巴拉
杰弗里·A·舒尔茨
斯科特·A·埃斯特拉达
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Arena Pharmaceuticals Inc
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Arena Pharmaceuticals Inc
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Publication of CN101084205A publication Critical patent/CN101084205A/zh
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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  • Health & Medical Sciences (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
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  • Psychiatry (AREA)
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  • Diabetes (AREA)
  • Addiction (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CNA2005800424116A 2004-12-13 2005-12-09 作为5ht2c受体调节剂以治疗与其相关病症的n－联芳基和n－芳基杂芳基哌嗪衍生物 Pending CN101084205A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63578504P 2004-12-13 2004-12-13
US60/635,785 2004-12-13

Publications (1)

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CN101084205A true CN101084205A (zh) 2007-12-05

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CNA2005800424116A Pending CN101084205A (zh) 2004-12-13 2005-12-09 作为5ht2c受体调节剂以治疗与其相关病症的n－联芳基和n－芳基杂芳基哌嗪衍生物

Country Status (7)

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US (1) US20080119477A1 (https=)
EP (1) EP1828156A2 (https=)
JP (1) JP2008523075A (https=)
CN (1) CN101084205A (https=)
AU (1) AU2005316825A1 (https=)
CA (1) CA2588595A1 (https=)
WO (1) WO2006065600A2 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006124865A2 (en) * 2005-05-19 2006-11-23 Vertex Pharmaceuticals Incorporated Biaryls derivatives useful as modulators of ion channels
WO2006130493A2 (en) 2005-05-31 2006-12-07 Vertex Pharmaceuticals Incorporated Heterocycles useful as modulators of ion channels
EP2742936A1 (en) 2006-05-16 2014-06-18 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
EP2789338A3 (en) 2007-11-15 2015-01-14 Takeda Pharmaceutical Company Limited Condensed pyridine derivate and use thereof
BRPI0908098A2 (pt) * 2008-02-19 2015-08-18 Adolor Corp Beloxepina, composição, métodos para tratar dor em um mamífero, para inibir a recaptação de ne, para antagonizar um receptor de 5ht2 e para tratar um distúrbio em um paciente que é responsivo ao tratamento com um composto nri e com um composto antagonista de 5ht2
JPWO2011071136A1 (ja) 2009-12-11 2013-04-22 アステラス製薬株式会社 線維筋痛症治療剤
US8492591B2 (en) 2010-02-04 2013-07-23 The Board Of Trustees Of The University Of Illinois Highly selective 5-HT(2C) receptor agonists that show anti-psychotic effects with antagonist activity at the 5-HT(2B) receptor
US20130267500A1 (en) 2010-09-01 2013-10-10 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
CN107810175B (zh) 2015-01-29 2021-06-15 伊利诺伊大学评议会 作为选择性5-ht(2c)受体激动剂的环丙基甲胺
EP3733204A4 (en) 2017-12-27 2021-09-15 Takeda Pharmaceutical Company Limited THERAPEUTIC AGENT FOR URINARY INCONTINENCE OF STRESS AND FECAL INCONTINENCE

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA7546B (en) * 1974-01-21 1976-08-25 Parke Davis & Co New antibacterial amide compounds and methods for their production
CA2144669A1 (en) * 1994-03-29 1995-09-30 Kozo Akasaka Biphenyl derivatives
DE59911249D1 (de) * 1998-11-03 2005-01-13 Abbott Gmbh & Co Kg Substituierte 2-phenylbenzimidazole, deren herstellung und anwendung
DE19939745A1 (de) * 1999-08-21 2001-02-22 Boehringer Ingelheim Pharma Substituierte Piperazinderivate, ihre Herstellung und ihre Verwendung als Arzneimittel
DE19939516A1 (de) * 1999-08-20 2001-02-22 Boehringer Ingelheim Pharma Substituierte Piperazinderivate, ihre Herstellung und ihre Verwendung als Arzneimittel
EP1745047B1 (en) * 2004-04-21 2010-03-24 Schering Corporation Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine adenosine-a2a- receptor antagonists

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EP1828156A2 (en) 2007-09-05
AU2005316825A1 (en) 2006-06-22
US20080119477A1 (en) 2008-05-22
WO2006065600A3 (en) 2006-08-03
WO2006065600A2 (en) 2006-06-22
CA2588595A1 (en) 2006-06-22
JP2008523075A (ja) 2008-07-03

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