CN101081234B - Method for preparation of claybank propolis soft capsules - Google Patents
Method for preparation of claybank propolis soft capsules Download PDFInfo
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- CN101081234B CN101081234B CN2007100030859A CN200710003085A CN101081234B CN 101081234 B CN101081234 B CN 101081234B CN 2007100030859 A CN2007100030859 A CN 2007100030859A CN 200710003085 A CN200710003085 A CN 200710003085A CN 101081234 B CN101081234 B CN 101081234B
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- propolis
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Abstract
The present invention provides preparation process of brown yellow soft propolis capsule, and the preparation process uses no chemical emulsifier, cosolvent and surfactant and has no change of pH value of propolis. The preparation process includes dissolving propolis in vegetable oil to form oil soluble propolis, solid-liquid separating, dissolving solid matter, concentrating, merging, regulatingthe effective component content and encapsulating. The brown yellow soft propolis capsule has high stability, bright color, high effective component content, low heavy metal content, no toxic side effect and obvious health care function.
Description
Technical field
The present invention relates to a kind of preparation method of claybank propolis soft capsules, belong to the Medicines and Health Product production field.
Background technology
Propolis is the resinae material that Apis is gathered from glue source plant innovation axillalry bud, alabastrum place, site of injury, injects its glandular secretion thing and processes the colloid substance that is transformed repeatedly through Apis.The main effective component of propolis is a propolis total flavones, has special biologic activity, is widely used in the Medicines and Health Product production field.
The bee glue soft capsule that conventional art is produced, poor stability is easy to generate the content segregation phenomenon, and the propolis composition is separated out from oil, forms the black " flake " clearly demarcated through Weihe.Cause bioavailability to reduce, influence medicinal health care function.
The bee glue soft capsule that prior art is produced, be that solvent is processed into black bee glue soft capsule (its color blackening be chemicals effect due to) how with chemical emulsifier, cosolvent, surfactant (as Tweens, spans, polyethylene glycols etc.), though stability has improved, but chemical emulsifier and catabolite thereof that excess is used have certain toxic and side effects.
Summary of the invention
The invention provides a kind of any chemical emulsifier, cosolvent, surfactant of not using, do not change the preparation method of the claybank propolis soft capsules of propolis pH value yet, promptly remedy the deficiency of conventional art, also avoided the adverse effect of chemicals in the prior art.
Preparation method of the present invention is: dissolve propolis with edible vegetable oil, after the solid-liquid separation, solid content, is incorporated in the molten thing of propolis oil after concentrating with oil or mixed solution dissolving, and homogenizing is regulated effective component content to standard-required, recharges and makes soft capsule.The mixed solution of dissolved solid is used drinking pure water and edible ethanol, fits in the solution of alcohol content 55%-85%.The temperature of edible vegetable oil dissolving propolis is controlled at 20 ℃～35 ℃, slowly is heated to 80 ℃ after 12 hours, and heating process was controlled at 12 hours, and accumulative total got final product solid-liquid separation after 24 hours.
In the preparation method of the present invention, edible vegetable oil is selected Oleum Hippophae, Oleum Vitis viniferae, Testa oryzae oil, olive oil, Camellia oil, Oleum Helianthi, Fructus Maydis oil, Oleum Arachidis hypogaeae semen, Semen sojae atricolor wet goods, dissolving propolis after single variety or many kinds are in harmonious proportion.The selection of edible vegetable oil is good with the high kind of unsaturated fatty acid content.The ratio of selected natural fresh propolis and edible vegetable oil is 1: 3-1: 8.
The characteristics of the claybank propolis soft capsules that preparation method of the present invention is produced are: pale brown color, color is vivid, and is consistent with the pale brown color of high-quality natural fresh propolis, do not using under any pigment prerequisite, is vivid pale brown color.Utilize the basic composition material of propolis, interact, form the molten thing of propolis oil with the edible vegetable oil composition, good stability, the effective component content height, content of beary metal is low, and is without any side effects, and medicinal health care function is remarkable.
Description of drawings
Accompanying drawing is a kind of claybank propolis soft capsules technological process of production sketch map.
The specific embodiment
Below in conjunction with embodiment, further set forth the present invention.Should be understood that embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.
Selected natural fresh propolis, behind the freezing and pulverizing, add in the edible vegetable oil, fully stir, slowly heat solid-liquid separation after 24 hours, solid content is partly with oil or mixed solution dissolving, after concentrating, be incorporated in the molten thing of propolis oil homogenizing, regulate active ingredient to standard-required, recharge and make soft capsule.
The claybank propolis soft capsules of the inventive method preparation, total flavone content in propolis is 30mg/ml, total flavone content in propolis is realized adjusting by the ratio of adjusting propolis and edible vegetable oil.Per kilogram natural fresh propolis can be produced net weight 4-9 kilogram manufactured goods.
Selected natural fresh propolis of the present invention also can be selected with refining dry extract or fluid extract or the concentrated solution etc. that form of selected natural fresh propolis, and they belong to technical equivalence and replace.
The invention provides a kind of method of producing claybank propolis soft capsules with edible vegetable oil; therefore in other embodiments; can mix (waiting conventional means to be achieved by experiment) with prior art, this type of mixing is not creative, belongs to protection scope of the present invention equally.
Claims (10)
1. the preparation method of a claybank propolis soft capsules is characterized in that: dissolve propolis with edible vegetable oil, after the solid-liquid separation, solid content after concentrating, is incorporated into homogenizing in the molten thing of propolis oil partly with oil or mixed solution dissolving, regulate active ingredient to standard-required, recharge and make soft capsule; The mixed solution of dissolved solid is used drinking pure water and edible ethanol, fits in the solution of alcohol content 55%-85%.
2. the preparation method of a kind of claybank propolis soft capsules according to claim 1, it is characterized in that: described propolis is selected natural fresh propolis, and the ratio of selected natural fresh propolis and edible vegetable oil is 1: 3-1: 8.
3. the preparation method of a kind of claybank propolis soft capsules according to claim 1, it is characterized in that: described propolis is selected natural fresh propolis, or selects to make with extra care dry extract or fluid extract or the concentrated solution that forms with selected natural fresh propolis.
4. according to the preparation method of claim 1,2 or 3 described a kind of claybank propolis soft capsules, it is characterized in that: the temperature of edible vegetable oil dissolving propolis is controlled at 20 ℃～35 ℃, slowly be heated to 80 ℃ after 12 hours, heating process was controlled at 12 hours, and accumulative total is solid-liquid separation after 24 hours.
5. according to the preparation method of claim 1,2 or 3 described a kind of claybank propolis soft capsules, it is characterized in that: total flavone content in propolis is in the claybank propolis soft capsules: 30mg/ml, total flavone content in propolis is realized adjusting by the ratio of adjusting propolis and edible vegetable oil.
6. the preparation method of a kind of claybank propolis soft capsules according to claim 4, it is characterized in that: total flavone content in propolis is in the claybank propolis soft capsules: 30mg/ml, total flavone content in propolis is realized adjusting by the ratio of adjusting propolis and edible vegetable oil.
7. according to the preparation method of claim 1,2,3 or 6 described a kind of claybank propolis soft capsules, it is characterized in that: the color of claybank propolis soft capsules is consistent with natural fresh propolis color, is not using under any pigment prerequisite, is vivid pale brown color.
8. the preparation method of a kind of claybank propolis soft capsules according to claim 4, it is characterized in that: the color of claybank propolis soft capsules is consistent with natural fresh propolis color, is not using under any pigment prerequisite, is vivid pale brown color.
9. the preparation method of a kind of claybank propolis soft capsules according to claim 5, it is characterized in that: the color of claybank propolis soft capsules is consistent with natural fresh propolis color, is not using under any pigment prerequisite, is vivid pale brown color.
10. propolis-containing medicine or the propolis-containing health food of being produced according to each described preparation method of claim 1-9.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100030859A CN101081234B (en) | 2007-02-02 | 2007-02-02 | Method for preparation of claybank propolis soft capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100030859A CN101081234B (en) | 2007-02-02 | 2007-02-02 | Method for preparation of claybank propolis soft capsules |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101081234A CN101081234A (en) | 2007-12-05 |
| CN101081234B true CN101081234B (en) | 2010-09-22 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007100030859A Expired - Fee Related CN101081234B (en) | 2007-02-02 | 2007-02-02 | Method for preparation of claybank propolis soft capsules |
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| CN (1) | CN101081234B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101912111B (en) * | 2010-07-19 | 2012-09-26 | 马建中 | Method for preparing high-content propolis soft capsules |
| CN102078337A (en) * | 2011-01-14 | 2011-06-01 | 哈药集团密山蜂业有限公司 | Propolis natural reduction extraction process method |
| CN102133237A (en) * | 2011-03-31 | 2011-07-27 | 射阳县庆缘康蜂产品厂 | Propolis flavone soft capsule and preparation method thereof |
| CN102349605A (en) * | 2011-10-19 | 2012-02-15 | 北京农科亿健蜂产品研究院 | Propolis extraction method and propolis capsule |
| CN106617049A (en) * | 2016-09-29 | 2017-05-10 | 广州市汇吉科技企业孵化器有限公司 | Propolis healthcare product with moringa oleifera leaf extract and method for preparing propolis healthcare product |
| CN108813499A (en) * | 2018-07-09 | 2018-11-16 | 武汉康思农生物科技有限公司 | A kind of bee glue soft capsule formula and preparation process |
| CN111000881B (en) * | 2019-12-27 | 2021-09-10 | 蜂乃宝本铺（南京）保健食品有限公司 | Propolis soft capsule rich in flavone and belonging to genus Brazilian breynia and preparation method thereof |
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2007
- 2007-02-02 CN CN2007100030859A patent/CN101081234B/en not_active Expired - Fee Related
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| Publication number | Publication date |
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| CN101081234A (en) | 2007-12-05 |
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Granted publication date: 20100922 Termination date: 20210202 |