CN101069637A - Retina pleochroism space-image modulation degree detection based on personalized eye model - Google Patents
Retina pleochroism space-image modulation degree detection based on personalized eye model Download PDFInfo
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Abstract
The present invention uses personalized human eye model as basis to obtain retinal spatial image modulation depth AIM standard curve of human eye under the polychromolight, belonging to the field of medicine diagnosis technology. It is characterized by that said invention adopts the following steps: using actually measured wavefront aberration of human eye, corneal characteristic parameters and intra-ocular every portion axial spacing distance data to create the personalized human eye model, then in said personalized human eye model setting working wavelength as visible light wave band so as to obtain the modulation transfer function MTF of optical system of human eye under the polychromolight; utilizing the relationship between correspondent MTF value and contrast sensitivity function value under the same space frequency to obtain the retinal AIM data of correspondent space frequency position; using the AIM value of space frequency position correspondent to the acuteness as MTF value of correspondent position so as to obtain the standard curve of retinal spatial image modulation depth AIF of normal human eye having no ketinal disease. Said invention can be used for diagnosing the retinal disease and diseases of optic nerve.
Description
Technical field
The invention belongs to the medical diagnostic techniqu field.
Background technology
The examination of visual acuity of ophthalmology mainly is to utilize common visual acuity chart to finish at present, and this check result is the full visual system whole visual function of (comprising that human eye dioptric system and retina are to the brain part); And concerning clinically some refractive medias muddy and some patients that can not obtain to correct defects of vision through conventional correction of refractive errors, the visual function evaluation then only need effectively be understood retina to brain visual function partly.Human eye retina's aerial image modulation degree AIM (Aerial Image Modulation), be and remove dioptric system and be the mensuration of the retina that carries out of starting point with the retina to the potential visual function of brain system, it not only plays an important role in the research of vision physiological, also being a highstrung index on clinical ophthalmology, is an important means of ophthalmic research, diagnosis.
Initial laser interferance method is measured the instrument of human eye AIM curve, all is to interfere with double laser beams to produce the striped sighting target light as a setting after handling through filtering with tengsten lamp.Owing to used two kinds of different light sources, the two electrical characteristic difference, the precision of the AIM numerical value that influence is recorded.Simultaneously, owing to measure human eye AIM curve with two arbitrary sources, the modulation degree of its striped sighting target will change with mains fluctuations, influence the stability of instrument.
Afterwards, there is the scholar to propose the novel light channel structure of single lasing light emitter, to improve the accuracy of detection of instrument: utilization laser interference principle, two-beam is focused into two luminous points at human eye node place, not having refraction ground then invests on the retina, superposition produces interference fringe, and with this interference fringe as sighting target; Distance on the ratio of the light intensity by regulating this two-beam and the node face between these two luminous points is regulated the interference fringe contrast and the spatial frequency that are produced, thereby determines the required subretinal space of human eye identification as modulation degree.This measuring method has been avoided the influence of human eye refracting media, make measurement result be subjected to the eye optical system Effect on Performance hardly, thereby has obtained subretinal space under monochromatic (accurate monochromatic) light as modulation degree AIM curve.But, all be the polychromatic light world usually because human eye sees, this technology can not provide the reflection characteristic of human eye retina to the polychromatic light world.
At present, AIM is very responsive to many ophthalmics, but does not reach the degree of carrying out Differential Diagnosis, and main cause is that AIM lacks quantitative target.Because subretinal space has nothing to do as the MTF (or Snazzi degree) of modulation degree AIM curve and optics of the eye system, the visual characteristic of promptly not having normal eye's retina of retina pathological changes and subsequent optic nerve, brain system is close; Therefore can be by calculating its assembly average of AIM curve acquisition of many (more than 100) normal eyes, as the standard curve of normal eye's subretinal space, be used for umpire's eyes retina and optic nerve disease as modulation degree AIM.
Summary of the invention
The purpose of this patent is to obtain the standard curve of human eye retina's aerial image modulation degree AIM under the polychromatic light.Human eyes wave-front optical aberration, cornea characteristic parameter and ophthalmic each several part axial spacing data with actual measurement are the fundamental construction personalized human-eye model, utilize Zemax software to obtain the modulation transfer function (MTF) MTF of opthalmic optics system under the polychromatic light; Utilize the association between it and full visual system contrast sensitivity function and the Snazzi degree, obtains corresponding each AIM curve, get its statistical average, obtain the AIM standard curve of polychromatic light time no retina pathological changes, as the index of medical science Differential Diagnosis.
This invention has following function and advantage:
Function one, the wavefront aberration data of known actual human eye, cornea characteristic parameter and ophthalmic each several part axial spacing data, utilization optical design software Zemax makes up personalized human-eye model, thereby obtains the modulation transfer function (MTF) MTF of opthalmic optics system under the polychromatic light.
Function two, according to the MTF curve of same eyes, full eye contrast sensitivity function and Snazzi degree, the subretinal space that obtains every eyes under the polychromatic light is as modulation degree AIM.
Function three because subretinal space is irrelevant as the MTF (or Snazzi degree) of modulation degree AIM curve and optics of the eye system, therefore can be obtained its standard curve by calculating many AIM, as the standard of umpire's eyes retina and optic nerve disease.
Concrete technical scheme
The technical scheme of this invention comprises following main aspect:
One is accurately measured former and later two surfaces of individual eye cornea with respect to a certain relative altitude value of deciding sphere of getting by the medical cornea activity mapping instrument, carries out the shape match with the high order aspheric surface functional form, brings in the eye model; Measure the axial width of each several parts such as human eye's anterior chamber, crystalline lens, vitreous body with medical A-mode ultrasonic wave technology, these thickness are imported in the eye model as optical interval; In the refractive index data of Gullstrand-Le Grand eye model input eye model, the lens surface shape is optimized, make the eye model wave aberration equate with the actual wave aberration that personnel selection glances wavefront aberrometer measures.
They are two years old, the actual wave aberration that the aberration of human eye instrument measures obtains under monochromatic light, after setting up eye model, utilizes Zemax software, by setting operation wavelength is visible light wave range, obtains the modulation transfer function (MTF) of opthalmic optics system under the polychromatic light.
Its three, human eye contrast sensitivity function and Snazzi degree are directly to measure under polychromatic light.
Its four, according to the association between corresponding M TF numerical value under each spatial frequency and contrast sensitivity function value CSF, MTF numerical value and the Snazzi degree VA, obtain the retina AIM data at corresponding space frequency place; Calculate many AIM numerical value and obtain the AIM standard curve.
Description of drawings
Accompanying drawing 1 is the flow chart that the present invention makes up personalized eye model.
Accompanying drawing 2 is structure principle charts that the present invention calculates retina AIM curve.
Specify embodiments of the present invention below in conjunction with accompanying drawing.
Concrete embodiment
As shown in Figure 1, corneal topographer Orbscan II[1] be used for measuring corneal curvature and cornea front and rear surfaces height value with respect to the reference sphere.Anterior corneal surface is converted into vertically difference in height along the difference in height of radius vector direction, simulates the aspheric surface form of cornea with the high order aspheric surface function.
Hartmann-Shack Wavefront sensor [2] is used for measuring the wave front aberration of human eye, the aberration data of individual human eye is joined in the majorized function of optical design software Zemax, defines the actual aberration of human eye with this.
A-mode ultrasonic calibrator [3] is used for measuring the each several part spacing of axis oculi, comprises cornea front and rear surfaces spacing, the camera oculi anterior degree of depth, lens thickness and Vitrea thickness.
The ophthalmic optical system comprises cornea, aqueous humor, crystalline lens and Vitrea medium refraction index [4] The data Gullstrand eye model numerical value.
The face type of crystalline lens [5] is set to Ze Nike rise face, optimizes lenticular front and rear surfaces, makes the wave aberration of full eye equate with the actual wave aberration that personnel selection glances wavefront aberrometer measures.Personalized human-eye model [6] made up and finished this moment.
After eye model was set up, the operation wavelength that changes in the Zemax software was a visible light wave range, obtains the modulation transfer function (MTF) of opthalmic optics system under the polychromatic light.
As shown in Figure 2, the CSV-1000 tester is used for measuring the contrast sensitivity function CSF[1 of the full visual system of human eye under the polychromatic light]; The personalized human-eye model that makes up among Fig. 1 is used for the modulation transfer function (MTF) MTF[2 of the opthalmic optics system under the polychromatic light that obtains]; Snazzi degree tester is used for measuring human eye Snazzi degree VA[3].
Corresponding M TF numerical value passes through division operation mutually with contrast sensitivity function numerical value under each spatial frequency, is the retina AIM data at corresponding space frequency place; The AIM numerical value at the pairing spatial frequency of Snazzi degree place is the mtf value of corresponding position.
Claims (4)
1. mensuration based on human eye retina's aerial image modulation degree AIM standard curve under the polychromatic light of personalized human-eye model, measuring system comprises the wavefront aberration measuring device, contrast sensitivity measuring device, visual acuity function test set.
2. require described personalized human-eye model according to right 1, comprise cornea, crystalline lens and amphiblestroid structure.It is characterized in that: the wave front aberration by personalized human-eye model full aberration that gets and the actual human eye that measures with wavefront analyzer equates; Obtain the modulation transfer function (MTF) MTF of opthalmic optics system under the polychromatic light then.
3. require described opthalmic optics's system modulation transfer function MTF according to right 2, and full contrast sensitivity function CSF and the Snazzi degree VA of visual system under polychromatic light, human eye retina's aerial image modulation degree AIM under the polychromatic light calculated.
4. require described human eye retina's aerial image modulation degree AIM according to right 3, calculate the standard curve of normal eye's subretinal space of no retina pathological changes, as the standard of Differential Diagnosis retina and optic nerve disease as modulation degree AIM.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102467612A (en) * | 2010-11-18 | 2012-05-23 | 沈阳理工大学 | Method for constructing individual eye optical model |
| CN102905610A (en) * | 2009-10-02 | 2013-01-30 | 光电子集团 | Diagnostic method and apparatus for predicting potential preserved visual acuity |
| CN108066006A (en) * | 2016-11-11 | 2018-05-25 | 鸿富锦精密工业（深圳）有限公司 | Vision correction effect simulation system and method |
| CN114587775A (en) * | 2020-12-04 | 2022-06-07 | 艾维斯技术有限责任公司 | Customized ablation for correcting vision ametropia |
-
2006
- 2006-05-09 CN CN 200610013617 patent/CN101069637A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102905610A (en) * | 2009-10-02 | 2013-01-30 | 光电子集团 | Diagnostic method and apparatus for predicting potential preserved visual acuity |
| CN102467612A (en) * | 2010-11-18 | 2012-05-23 | 沈阳理工大学 | Method for constructing individual eye optical model |
| CN108066006A (en) * | 2016-11-11 | 2018-05-25 | 鸿富锦精密工业（深圳）有限公司 | Vision correction effect simulation system and method |
| CN114587775A (en) * | 2020-12-04 | 2022-06-07 | 艾维斯技术有限责任公司 | Customized ablation for correcting vision ametropia |
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