CN101040912A - Chinese traditional medicine capsule preparation for resisting radiation and improving immunity and the method for preparing the same - Google Patents
Chinese traditional medicine capsule preparation for resisting radiation and improving immunity and the method for preparing the same Download PDFInfo
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- CN101040912A CN101040912A CNA2007100145922A CN200710014592A CN101040912A CN 101040912 A CN101040912 A CN 101040912A CN A2007100145922 A CNA2007100145922 A CN A2007100145922A CN 200710014592 A CN200710014592 A CN 200710014592A CN 101040912 A CN101040912 A CN 101040912A
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Abstract
The invention relates to a Chinese capsule for resisting radiation and improving immunity and relative preparation, belonging to Chinese drug technique, wherein the capsule comprises mulberry leaf extractive at 40-60 deals, taurine at 150-200 deals, dextran at 50-10 deals, and donkey-hide gelatin powder at 50-100 deals. And the preparation comprises that boiling mulberry leaf for two times, combining and filtering to be concentrated into paste, adding alcohol to make the alcohol content to 70-85%, laying, filtering, drying deposits to obtain powder mulberry leaf extractive, mixing the extractive with taurine, dextran and donkey-hide gelatin powder, packing into capsule. The inventive capsule can effectively reduce the hurt of 60Co gamma radiation on blood system, resist radiation immunity hurt, repair hurt organism, improve immunity or the like, without side effect.
Description
Technical field
The present invention relates to the natural drug of a kind of radioprotective, enhance immunity, be specifically related to a kind of Chinese medicinal capsule preparation and preparation method thereof, belong to middle field of pharmaceutical technology.
Background technology
The influence of ionizing electromagnetic radiation is ubiquitous in the modern life: arrive diagnostic equipments such as grid, nuclear power station, radio and television launching tower, communication emission, large-scale medical X, gamma-rays greatly; Little to small stores such as television set, electric refrigerator, microwave oven, air-conditioning, computer, mobile phones all launching the ionizing electromagnetic radiation of different capacity towards periphery, be called as the ionization electromagnetic pollution.Radiation effects can make the relevant organ of human body morph in human body, can cause diseases such as headache, dizzy, weak, insomnia, hypomnesis, and can cause malignant change such as leukemia.Some chemicals has also produced a series of side effect and can bring out other pathological changes body in the control radiation damage.Utilize the effective active composition enhancing body resistance in the natural plants, prevent or alleviate the harm of radiation, just receiving more and more scholars' concern health.
Summary of the invention
The invention provides Chinese medicinal capsule preparation of a kind of radioprotective, enhance immunity and preparation method thereof.
Chinese medicinal capsule preparation of the present invention is to be the capsule that content is made by following component, is weight portion:
Folium Mori extract 40-60 part, taurine 150-200 part, glucosan 5-10 part, Colla Corii Asini powder 50-100 part.
Described Folium Mori extract is that the drying precipitate behind Folium Mori decocting, the precipitate with ethanol is got.
Preferably, Chinese medicinal capsule preparation content component is as follows, is weight portion:
40 parts of Folium Mori extracts, 200 parts of taurines, 10 parts of glucosans, 50 parts in Colla Corii Asini powder.
The preparation method of Chinese medicinal capsule preparation of the present invention, step is as follows:
(1) with behind twice of the Folium Mori decocting, the 9-10 that amount of water is respectively Folium Mori weight doubly, 7-8 doubly, decocting time 1.5-2 hour respectively, 0.5-1 hour filter, merging filtrate concentrates and makes the extractum that relative density is 1.15-1.2 (50 ℃ of survey); Add ethanol and make and contain the alcohol amount and reach 70-85%, left standstill 8-15 hour, filter, precipitate is dry below 60 ℃, the powdery Folium Mori extract;
(2) Folium Mori crude extract polysaccharides of Folium Mori and taurine, glucosan and Colla Corii Asini powder are mixed in proportion, be distributed into capsule.
The present invention is primary raw material prescription compatibility, drug effect complementation, synergism with the Folium Mori extract.Wherein Folium Mori extract is rich in polysaccharide, energy raise immunity, radioprotective, antitumor.The basis shows with clinical test results: Chinese medicinal capsule preparation of the present invention has remarkable reduction
60The Co radiation gamma to the infringement of hemopoietic system, antagonism radiation immune injury, repair functions such as radiation damage tissue, raise immunity, antitumor, and safety is without any side effects.
Relevant test situation is as follows:
Experimentation shows that Chinese medicinal capsule preparation of the present invention (hereinafter to be referred as Mulberry cattle capsule) can make Hb, the RBC of resulted from chemical medicine, WBC, PC reduce obviously and improve, and can obviously improve
60Immunologic hypofunction mice serum antibody horizontal due to the Co gamma-rays strengthens humoral immune function, obviously improves
60Immunocompromised mice spleen lymphocytic hyperplasia cell transformation function due to the Co gamma-rays.Mulberry cattle capsule can watch for animals thymus, spleen tissue increase immunologic function, can make
60The immunocompromised bone marrow cells in mice transfers the rate of dying obviously to reduce due to the Co gamma-rays, and hepatocyte bc1-2 expresses positive cell rate and obviously improves.Mulberry cattle capsule has protective effect to the damage that radiation causes, its mechanism of action with improve SOD activity in the tissue, suppress lipid peroxidation, regulating cell bc1-2 gene expression and influence apoptosis-related.
Table 1 Mulberry cattle capsule causes the influence (X ± SD) of mouse hemopoietic system function to cyclophosphamide
| Group | Dosage (g/kg) | Number of animals (only) | HB(g/L) | RCB divides rate (10 12/L) | PC (10 11/L) | WBC |
| The heavy dose of group of normal control group model matched group Mulberry cattle capsule Mulberry cattle capsule small dose group EGUIYANGXUE group | - - 1.6 0.4 15ml/kg | 10 10 10 10 10 | 124.2±9.9 115.3±8.5 145.4±10.8 **129.6±14.7 *139.5±15.4 ** | 4.34±0.58 4.32±0.47 5.63±0.71 ** 5.07±0.75 * 5.62±0.54 ** | 1.68±0.48 1.36±0.38 2.31±0.64 ** 1.95±0.53 * 2.548±0.69 ** | 4.02±0.64 3.67±0.67 5.76±1.02 **4.45±0.82 *5.78±1.06 ** |
Compare * P＜0.05, * * P＜0.01 with model control group
Table 2 pair
60The influence of immunocompromised mouse humoral immune function due to the Co gamma-rays (X ± SD)
| Group | Dosage (g/kg) | Number of animals (only) | The OD value |
| The heavy dose of group of normal control group model matched group Mulberry cattle capsule Mulberry cattle capsule small dose group EGUIYANGXUE group | - - 1.6 0.4 15ml/kg | 10 10 10 10 10 | 0.191±0.049 0.097±0.038 0.163±0.053 ** 0.146±0.036 * 0.142±0.041 * |
Compare with model group: * P＜0.05, * * P＜0.01
Table 3 pair
60The influence of immunocompromised mouse spleen lymphocyte transformation function due to the Co gamma-rays (X ± SD)
| Group | Dosage (g/kg) | Number of animals (only) | Stimulation index (SI) |
| The heavy dose of group of normal control group model matched group Mulberry cattle capsule Mulberry cattle capsule small dose group EGUIYANGXUE group | - - 1.6 0.4 15ml/kg | 10 10 10 10 10 | 2.33±0.45 1.51±0.53 2.08±0.46 ** 1.96±0.62 * 1.92±0.48 * |
Compare * P＜0.05, * * P＜0.01 with model group
Table 4 pair
60The influence of quantity of leucocyte in immunocompromised mice spleen, thymus index, the blood due to the Co gamma-rays (X ± SD)
| Group | Dosage (g/kg) | Number of animals (only) | Spleen index | Thymus index | Quantity of leucocyte |
| The heavy dose of group of normal control group model matched group Mulberry cattle capsule Mulberry cattle capsule small dose group EGUIYANGXUE group | - - 1.6 0.4 15ml/kg | 10 10 10 10 10 | 4.40±0.76 2.64±0.43 3.23±0.39 ** 2.99±0.34 3.05±0.35 * | 2.98±0.43 1.97±0.40 2.47±0.45 * 2.36±0.32 * 2.04±0.19 | 8.64±1.63 3.85±0.69 6.23±0.64 * 5.44±0.87 * 6.82±1.05 ** |
Compare * P＜0.05, * * P＜0.01 with model group
Table 5 pair
60The influence of immunocompromised SOD in Mice, MDA due to the Co gamma-rays (X ± SD)
| Group | Dosage (g/kg) | Number of animals (only) | Thymus | Spleen | ||
| SOD (kU/g) | MDA (mol/g) | SOD (kU/g) | MDA (mol/g) | |||
| The heavy dose of group of normal control group model matched group Mulberry cattle capsule Mulberry cattle capsule small dose group EGUIYANGXUE group | - - 1.6 0.4 15ml/kg | 10 10 10 10 10 | 69.27±4.52 50.26±2.19 86.61±4.61 ** 49.32±5.78 61.74±3.72 | 5.01±1.14 9.36±0.73 4.19±0.59 ** 6.33±0.68 5.11±0.92 ** | 67.92±5.11 47.54±4.36 84.32±2.89 ** 67.34±5.82 * 54.62±3.64 | 4.36±0.95 12.55±1.12 6.12±0.39 ** 7.52±0.62 ** 8.06±0.64 |
Compare * P＜0.05, * * P＜0.01 with model group
Table 6 pair
60The influence of immunocompromised mouse spleen lymphocyte transformation function due to the Co gamma-rays (X ± SD)
| Group | Dosage (g/kg) | Number of animals (only) | Apoptosis in bone marrow cells (%) | bc1-2(％) |
| The heavy dose of group of normal control group model matched group Mulberry cattle capsule Mulberry cattle capsule small dose group EGUIYANGXUE group | - - 1.6 0.4 15ml/kg | 10 10 10 10 10 | 2.46 15.69 4.62 *7.94 6.18 * | 77.4 50.6 68.5 ** 59.1 56.3 |
Compare * P＜0.05, * * P＜0.01 with model group
Table 7 Mulberry cattle capsule inhibition test result (X ± SD)
| Group | Dosage (g/kg) | Number of animals (only) | Tumor heavy (g) | Tumour inhibiting rate (%) |
| The heavy dose of group of normal control group cyclophosphamide group Mulberry cattle capsule Mulberry cattle capsule small dose group | - 0.004 1.6 0.4 | 10 10 10 10 | 2.11±0.62 0.98±0.43 ** 1.03±0.38 ** 1.22±0.44 * | - 53 51 42 |
Compare * P＜0.05, * * P＜0.01 with model group
Product of the present invention finds new growth engines for the utilization of raw materials such as Folium Mori when the development and use natural resources is developed natural Antiradiation injury preparation, have wide development prospect and tangible economic benefit.
The specific embodiment
The present invention will be further described below in conjunction with embodiment.
Embodiment 1:
The Chinese medicinal capsule preparation of a kind of radioprotective, enhance immunity is to be the capsule that content is made by following component:
Folium Mori extract 40g, taurine 200g, glucosan 10g, Colla Corii Asini powder 50g.
Preparation method, step is as follows:
(1) it is cataclasm to get Folium Mori, decoct with water 2 times, amount of water is respectively 10 times, 8 times of Folium Mori weight, decocting time was respectively 2,1 hours, filter, merge twice filtrate, being concentrated into about relative density is 1.15-1.2 (50 ℃ of surveys of density) extractum, add ethanol and make and contain the alcohol amount and reach 80%, left standstill 10 hours.Filter, precipitate is dry below 60 ℃, and it is standby to get powdery polysaccharides of Folium Mori crude extract.
(2) with above-mentioned polysaccharides of Folium Mori crude extract, add taurine, glucosan, Colla Corii Asini powder by proportioning, mix homogeneously divides promptly encapsulated.
Embodiment 2:
The Chinese medicinal capsule preparation of a kind of radioprotective, enhance immunity is to be the capsule that content is made by following component:
Folium Mori extract 50g, taurine 150g, glucosan 20g, Colla Corii Asini powder 80g.
Preparation method, step is as follows:
(1) it is cataclasm to get Folium Mori, decoct with water 2 times, amount of water is respectively 10 times, 8 times of Folium Mori weight, and decocting time was respectively 2,1 hours, filter, merge twice filtrate, being concentrated into relative density is 1.15-1.2 (50 ℃ of surveys of density) extractum, adds ethanol and makes and contain the alcohol amount and reach 75%, left standstill 12 hours, filter, precipitate is dry below 60 ℃, and it is standby to get powdery polysaccharides of Folium Mori crude extract.
(2) with above-mentioned polysaccharides of Folium Mori crude extract, add taurine, glucosan, Colla Corii Asini powder by proportioning, mix homogeneously divides promptly encapsulated.
Embodiment 3: as embodiment 1 described Chinese medicinal capsule preparation, different is that the content component is:
Folium Mori extract 60g, taurine 180g, glucosan 10g, Colla Corii Asini powder 50g.
Preparation method is with embodiment 1.
Claims (3)
1, the Chinese medicinal capsule preparation of a kind of radioprotective, enhance immunity is characterized in that being is the capsule that content is made by following component, is weight portion:
Folium Mori extract 40-60 part, taurine 150-200 part, glucosan 5-10 part, Colla Corii Asini powder 50-100 part,
Described Folium Mori extract is that the drying precipitate behind Folium Mori decocting, the precipitate with ethanol is got.
2, as claims 1 described Chinese medicinal capsule preparation, it is characterized in that the content component is as follows, be weight portion:
Folium Mori extract 40g, taurine 200g, glucosan 10g, Colla Corii Asini powder 50g.
3, a kind of preparation method of claims 1 described Chinese medicinal capsule preparation, step is as follows, is weight portion:
(1) with behind twice of the Folium Mori decocting, the 9-10 that amount of water is respectively Folium Mori weight doubly, 7-8 doubly, decocting time 1.5-2 hour respectively, 0.5-1 hour filter, merging filtrate concentrates and makes the extractum that relative density is 1.15-1.2 (50 ℃ of survey); Add ethanol and make and contain the alcohol amount and reach 70-85%, left standstill 8-15 hour, filter, precipitate is dry below 60 ℃, the powdery Folium Mori extract;
(2) Folium Mori crude extract and taurine, glucosan and Colla Corii Asini powder are mixed in proportion, be distributed into capsule.
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| CN101040912A true CN101040912A (en) | 2007-09-26 |
| CN101040912B CN101040912B (en) | 2010-05-19 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111514167A (en) * | 2020-05-09 | 2020-08-11 | 北京航空航天大学 | Application of donkey-hide gelatin in product for relieving oxidative stress injury of cells |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1480055A (en) * | 2002-09-06 | 2004-03-10 | 伟 孙 | Nuntritioin enhanced health tea for computer users and preparation method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111514167A (en) * | 2020-05-09 | 2020-08-11 | 北京航空航天大学 | Application of donkey-hide gelatin in product for relieving oxidative stress injury of cells |
| CN111514167B (en) * | 2020-05-09 | 2022-05-24 | 北京航空航天大学 | Application of donkey-hide gelatin in product for relieving oxidative stress injury of cells |
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| CN101040912B (en) | 2010-05-19 |
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