CN101035810B - 肝细胞生长因子激活剂的调控物 - Google Patents

肝细胞生长因子激活剂的调控物 Download PDF

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Publication number
CN101035810B
CN101035810B CN2005800338036A CN200580033803A CN101035810B CN 101035810 B CN101035810 B CN 101035810B CN 2005800338036 A CN2005800338036 A CN 2005800338036A CN 200580033803 A CN200580033803 A CN 200580033803A CN 101035810 B CN101035810 B CN 101035810B
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sequence
seq
antibody
cdr
hgfa
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CN101035810A (zh
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丹尼尔·K·柯克霍弗
吴雁
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN2005800338036A 2004-10-04 2005-10-03 肝细胞生长因子激活剂的调控物 Expired - Fee Related CN101035810B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61565704P 2004-10-04 2004-10-04
US60/615,657 2004-10-04
PCT/US2005/036300 WO2006042173A2 (en) 2004-10-04 2005-10-03 Modulators of hepatocyte growth factor activator

Publications (2)

Publication Number Publication Date
CN101035810A CN101035810A (zh) 2007-09-12
CN101035810B true CN101035810B (zh) 2011-04-06

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Family Applications (1)

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CN2005800338036A Expired - Fee Related CN101035810B (zh) 2004-10-04 2005-10-03 肝细胞生长因子激活剂的调控物

Country Status (15)

Country Link
US (4) US20060147451A1 (https=)
EP (1) EP1809673B1 (https=)
JP (2) JP4937127B2 (https=)
KR (1) KR101252306B1 (https=)
CN (1) CN101035810B (https=)
AU (1) AU2005294146B2 (https=)
BR (1) BRPI0515670A (https=)
CA (1) CA2577598C (https=)
ES (1) ES2398528T3 (https=)
IL (1) IL181450A0 (https=)
NO (1) NO20072302L (https=)
NZ (1) NZ553327A (https=)
RU (1) RU2418004C2 (https=)
WO (1) WO2006042173A2 (https=)
ZA (1) ZA200701789B (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0515670A (pt) 2004-10-04 2008-07-29 Genentech Inc anticorpos isolados e método de tratamento de uma doença associada com descontrole da sinalização do hgf/c-met
US8088908B2 (en) * 2005-05-10 2012-01-03 City Of Hope Humanized anti-prostate stem cell antigen monoclonal antibody
DK2056874T3 (da) * 2006-08-21 2012-10-15 Hoffmann La Roche Tumorterapi med et anti-vegf-antistof
AR065271A1 (es) * 2007-02-09 2009-05-27 Genentech Inc Anticuerpos anti-robo4 y sus usos
US20170204191A1 (en) * 2008-10-06 2017-07-20 Cynthia C. Bamdad Muc1* antibodies
US20110206704A1 (en) * 2009-10-19 2011-08-25 Genentech, Inc. Methods and compositions for modulating hepatocyte growth factor activator
US8759491B2 (en) * 2009-10-19 2014-06-24 Genentech, Inc. Modulators of hepatocyte growth factor activator
EP2491059B1 (en) 2009-10-22 2015-02-25 F.Hoffmann-La Roche Ag Anti-hepsin antibodies and methods using same
MX346500B (es) 2010-11-10 2017-03-22 Genentech Inc * Metodos y composiciones para inmunoterapia para enfermedad neural.
EP3221361B1 (en) 2014-11-19 2021-04-21 Genentech, Inc. Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use
WO2016081639A1 (en) 2014-11-19 2016-05-26 Genentech, Inc. Antibodies against bace1 and use thereof for neural disease immunotherapy
CA2976089C (en) 2015-02-10 2026-01-13 Minerva Biotechnologies Corporation Humanized anti-muc1* antibodies
WO2023172863A1 (en) * 2022-03-07 2023-09-14 Elixiron Immunotherapeutics (hong Kong) Limited Anti-cd36 antibodies and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1213302A1 (en) * 2000-12-05 2002-06-12 Mitsubishi Chemical Corporation Specific antibody directed to active but not inactive hepatocyte growth factor activator (HGFA)
US6407213B1 (en) * 1991-06-14 2002-06-18 Genentech, Inc. Method for making humanized antibodies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2102463A1 (en) * 1992-11-05 1994-05-06 Mitsubishi Chemical Corporation Protein and gene encoding said protein
US6309636B1 (en) * 1995-09-14 2001-10-30 Cancer Research Institute Of Contra Costa Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides
JP4090236B2 (ja) * 2000-12-05 2008-05-28 三菱化学株式会社 活性型肝細胞増殖因子アクティベーターに対する特異的抗体とその使用法
BRPI0515670A (pt) 2004-10-04 2008-07-29 Genentech Inc anticorpos isolados e método de tratamento de uma doença associada com descontrole da sinalização do hgf/c-met

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6407213B1 (en) * 1991-06-14 2002-06-18 Genentech, Inc. Method for making humanized antibodies
EP1213302A1 (en) * 2000-12-05 2002-06-12 Mitsubishi Chemical Corporation Specific antibody directed to active but not inactive hepatocyte growth factor activator (HGFA)

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Cao B et al.Neutralizing monoclonal antibodies to hepatocytegrowthfactor/scatter factor(HGF/SF) display antitumor activityinanimal models.Proceedings of the National Academy of Sciences of USA98 13.2001,98(13),7443-7448.
Cao B et al.Neutralizing monoclonal antibodies to hepatocytegrowthfactor/scatter factor(HGF/SF) display antitumor activityinanimal models.Proceedings of the National Academy of Sciences of USA98 13.2001,98(13),7443-7448. *
Hiroaki Kataoka et al.Activation of hepatocyte growth factor/scatter factor incolorectal carcinoma.Cancer Research60 21.2000,60(21),6148-6159页，具体参见［6149-6151页，6158页左栏第2段，图2C，摘要］.
Hiroaki Kataoka et al.Activation of hepatocyte growth factor/scatter factor incolorectal carcinoma.Cancer Research60 21.2000,60(21),6148-6159页,具体参见[6149-6151页,6158页左栏第2段,图2C,摘要]. *
Miyazawa K et al.Activation of hepatocyte growth factor in the injured tissues ismediated by hepatocyte growth factor activator.Journal of Biological Chemistry271 7.1996,271(7),3615-3618页，具体参见［3616-3617页，图2］.
Miyazawa K et al.Activation of hepatocyte growth factor in the injured tissues ismediated by hepatocyte growth factor activator.Journal of Biological Chemistry271 7.1996,271(7),3615-3618页,具体参见[3616-3617页,图2]. *

Also Published As

Publication number Publication date
US20130217862A1 (en) 2013-08-22
AU2005294146B2 (en) 2011-09-15
CN101035810A (zh) 2007-09-12
JP5554298B2 (ja) 2014-07-23
ES2398528T3 (es) 2013-03-19
US20110098449A1 (en) 2011-04-28
WO2006042173A2 (en) 2006-04-20
JP4937127B2 (ja) 2012-05-23
NZ553327A (en) 2010-02-26
NO20072302L (no) 2007-06-28
RU2007116806A (ru) 2008-11-10
IL181450A0 (en) 2007-07-04
EP1809673A2 (en) 2007-07-25
CA2577598C (en) 2016-09-20
US20060147451A1 (en) 2006-07-06
JP2012025752A (ja) 2012-02-09
KR101252306B1 (ko) 2013-04-08
WO2006042173A3 (en) 2006-08-17
US7825221B2 (en) 2010-11-02
US8969528B2 (en) 2015-03-03
EP1809673B1 (en) 2012-11-28
CA2577598A1 (en) 2006-04-20
JP2008515918A (ja) 2008-05-15
BRPI0515670A (pt) 2008-07-29
RU2418004C2 (ru) 2011-05-10
HK1105006A1 (en) 2008-02-01
US8399629B2 (en) 2013-03-19
KR20070102470A (ko) 2007-10-18
AU2005294146A1 (en) 2006-04-20
ZA200701789B (en) 2008-11-26
US20090047291A1 (en) 2009-02-19

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