CN101035559A - 多价禽流感疫苗 - Google Patents
多价禽流感疫苗 Download PDFInfo
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- CN101035559A CN101035559A CNA2005800336971A CN200580033697A CN101035559A CN 101035559 A CN101035559 A CN 101035559A CN A2005800336971 A CNA2005800336971 A CN A2005800336971A CN 200580033697 A CN200580033697 A CN 200580033697A CN 101035559 A CN101035559 A CN 101035559A
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Classifications
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Landscapes
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
成份名称 | 数量 | 作用 |
活性成份 | ||
灭活的禽流感病毒 | >128HA | 活性成份 |
H5N9病毒株 | ||
A/CK/Italy/22A/H5N9/1998 | ||
灭活的禽流感病毒, | >128HA | 活性成份 |
H7N1病毒株 | ||
A/CK/Italy/1067/H7N1/1999 | ||
佐剂组份 |
成份名称 | 数量 | 作用 |
轻质矿物油 | 230mg | 佐剂 |
去水山梨糖醇倍半油酸酯(植物的) | 22.5mg | 乳化剂 |
聚山梨醇酯80(植物的) | 4.3mg | 乳化剂 |
赋形剂组份 | ||
硫柳汞 | 0.02mg | 保存剂 |
磷酸盐缓冲盐水 | Ad 0.5ml | 稀释剂 |
抗原浓度 | 周龄 | HI滴度 | |||
H5N9 | H7N1 | ||||
FD | IZSV | FD | IZSV | ||
每一亚型皆为256HAu | 2w | 1 | 1 | 1 | 1 |
4w | 59.7 | 27.9 | 274.4 | 52 | |
6w | 1910.8 | 388 | 8780 | 1910.8 | |
10w | 73.5 | PR | 274.4 | PR | |
14w | 26 | PR | 168.9 | PR | |
每一亚型皆为128HAu | 2w | 1 | 1 | 1 | 1 |
4w | 39.4 | 13 | 274.4 | 32 | |
6w | 831.8 | 256 | 4390 | 831.8 | |
10w | 69.1 | PR | 276.5 | PR |
抗原浓度 | 周龄 | HI滴度 | |||
H5N9 | H7N1 | ||||
FD | IZSV | FD | IZSV | ||
14w | 50.8 | PR | 74.7 | PR | |
每一亚型皆为64HAu | 2w | 1 | 1 | 1 | 1 |
4w | 19.7 | 4.3 | 90.5 | 8 | |
6w | 861 | 207.9 | 2786.9 | 338 | |
10w | 42.2 | PR | 111.4 | PR | |
14w | 34.3 | PR | 64 | PR | |
每一亚型皆为32HAu | 2w | 1 | 1 | 1 | 1 |
4w | 4.6 | 1.87 | 13 | 2.1 | |
6w | 445.7 | 111.4 | 2048 | 157.6 | |
10w | 34.6 | PR | 52 | PR | |
14w | 27.4 | PR | 47 | PR | |
未经接种鸟 | 2w | 1 | 1 | 1 | 1 |
4w | 1 | 1 | 1 | 1 | |
6w | 1 | 1 | 1 | 1 | |
10w | 1 | PR | 1 | PR | |
14w | 1 | PR | 1 | PR |
抗原浓度 | 周龄 | 禽流感亚型 | |||
H5N9 | H7N1 | ||||
FD | IZSV | FD | IZSV | ||
第1组经接种雏鸡 | 2w | 1 | 1 | 1 | 1 |
5w | 374.8 | 163.1 | 955.4 | 304.4 | |
8w | 1351.2 | 588.1 | 14263.1 | 1782.9 | |
第2组对照 | 2w | 1 | 1 | 1 | 1 |
5w | 1 | 1 | 1 | 1 | |
8w | 1 | 1 | 1 | 1 |
阳性 | 阴性 | 合计 | |
经接种鸟 | 1 | 9 | 10 |
未经接种鸟 | 9 | 1 | 10 |
阳性 | 阴性 | 合计 | |
经接种鸟 | 44 | 96 | 140 |
未经接种鸟 | 57 | 69 | 126 |
激发前H5N2 | 激发后H5N2 | 激发前H5N9 | 激发后H5N9 | |
经接种鸟 | 7.2* | 9.6 | 6.0 | 6.9 |
未经接种鸟 | 0 | 8.5 | 0 | 6.2 |
阳性 | 阴性 | 合计 | |
经接种鸟 | 1 | 9 | 10 |
未经接种鸟 | 9 | 1 | 10 |
阳性 | 阴性 | 合计 | |
经接种鸟 | 21 | 119 | 140 |
未经接种鸟 | 63 | 63 | 126 |
激发前H7N1 | 激发后H7N1° | 激发前H7N3 | 激发后H7N3 | |
经接种鸟 | 8.4* | 10.6 | 5.3 | 7.1 |
未经接种鸟 | 0 | 9 | 0 | 6.8 |
阳性 | 阴性 | 合计 | |
经接种鸟 | 0 | 10 | 10 |
未经接种鸟 | 4 | 6 | 10 |
阳性 | 阴性 | 合计 | |
经接种鸟 | 0 | 140 | 140 |
未经接种鸟 | 10 | 130 | 140 |
激发前H5N2 | 激发后H5N2 | 激发前H5N9 | 激发后H5N9 | |
经接种鸟 | 8.9* | 9.6 | 7.7 | 8.5 |
未经接种鸟 | 0 | 4.1 | 0 | 4.1 |
阳性 | 阴性 | 总计 | |
经接种鸟 | 0 | 10 | 10 |
未经接种鸟 | 7 | 3 | 10 |
阳性 | 阴性 | 合计 | |
经接种鸟 | 2 | 138 | 140 |
未经接种鸟 | 25 | 115 | 140 |
激发前H7N1 | 激发后H7N1° | 激发前H7N3 | 激发后H7N3 | |
经接种鸟 | 8.4* | 10.8 | 6.1 | 6.1 |
未经接种鸟 | 0 | 5 | 0 | 3.5 |
Claims (20)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61670704P | 2004-10-07 | 2004-10-07 | |
US60/616,707 | 2004-10-07 | ||
US64845905P | 2005-01-31 | 2005-01-31 | |
US60/648,459 | 2005-01-31 | ||
PCT/US2005/035925 WO2006041978A2 (en) | 2004-10-07 | 2005-10-06 | Multivalent avian influenza vaccines |
Publications (2)
Publication Number | Publication Date |
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CN101035559A true CN101035559A (zh) | 2007-09-12 |
CN101035559B CN101035559B (zh) | 2011-08-17 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2005800336971A Active CN101035559B (zh) | 2004-10-07 | 2005-10-06 | 多价禽流感疫苗 |
Country Status (17)
Country | Link |
---|---|
US (1) | US8067013B2 (zh) |
EP (1) | EP1796720B1 (zh) |
JP (1) | JP5105524B2 (zh) |
KR (1) | KR101370464B1 (zh) |
CN (1) | CN101035559B (zh) |
AP (1) | AP2167A (zh) |
AR (1) | AR051636A1 (zh) |
AU (1) | AU2005294322A1 (zh) |
BR (1) | BRPI0516542B1 (zh) |
CA (1) | CA2581355C (zh) |
ES (1) | ES2467094T3 (zh) |
MX (1) | MX2007004004A (zh) |
MY (1) | MY153290A (zh) |
NZ (1) | NZ553975A (zh) |
TW (1) | TWI365074B (zh) |
WO (1) | WO2006041978A2 (zh) |
ZA (1) | ZA200702876B (zh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101495139A (zh) * | 2005-11-10 | 2009-07-29 | 迪娃解决方案股份有限公司 | 鉴别治疗组合物 |
US9072701B2 (en) * | 2006-04-21 | 2015-07-07 | St. Jude Children's Research Hospital | Avian influenza viruses, vaccines, compositions, formulations, and methods |
US20100098721A1 (en) * | 2006-10-18 | 2010-04-22 | St. Jude Children's Reseach Hospital | Methods and compositions for preparing a universal influenza vaccine |
CL2008000747A1 (es) * | 2007-03-16 | 2008-04-25 | Wyeth Corp | Composicion de vacuna que comprende una primera y una segunda cepa inactivada del virus de la influenza aviar; metodo para vacunar un ave. |
GB0810305D0 (en) * | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
CA2729248A1 (en) | 2008-06-25 | 2009-12-30 | Novartis Ag | Rapid responses to delayed booster immunisations |
JP5558360B2 (ja) | 2008-10-08 | 2014-07-23 | ポッカサッポロフード&ビバレッジ株式会社 | 抗鳥インフルエンザウイルス剤及びその使用 |
CN107949636B (zh) * | 2015-06-04 | 2021-11-09 | 香港大学 | 活减毒病毒以及生产和使用方法 |
KR101964044B1 (ko) | 2018-03-14 | 2019-04-02 | 인제대학교 산학협력단 | 재조합 아데노바이러스를 이용한 다가형 인플루엔자 생백신 플랫폼 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
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HU212924B (en) * | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
US6159472A (en) * | 1998-11-16 | 2000-12-12 | Akzo Nobel N.V. | Intradermal Avian immunization with inactivated vaccines |
EP1980268A2 (en) * | 2002-04-12 | 2008-10-15 | Ilaria Capua | Vaccination methods against avian influenza virus |
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2005
- 2005-09-29 TW TW094133947A patent/TWI365074B/zh active
- 2005-10-06 AP AP2007003955A patent/AP2167A/xx active
- 2005-10-06 WO PCT/US2005/035925 patent/WO2006041978A2/en active Application Filing
- 2005-10-06 KR KR1020077009400A patent/KR101370464B1/ko active IP Right Grant
- 2005-10-06 BR BRPI0516542A patent/BRPI0516542B1/pt active IP Right Grant
- 2005-10-06 JP JP2007535798A patent/JP5105524B2/ja active Active
- 2005-10-06 AR ARP050104219A patent/AR051636A1/es unknown
- 2005-10-06 US US11/244,574 patent/US8067013B2/en active Active
- 2005-10-06 ES ES05816010.2T patent/ES2467094T3/es active Active
- 2005-10-06 MX MX2007004004A patent/MX2007004004A/es active IP Right Grant
- 2005-10-06 EP EP05816010.2A patent/EP1796720B1/en active Active
- 2005-10-06 NZ NZ553975A patent/NZ553975A/en unknown
- 2005-10-06 CA CA2581355A patent/CA2581355C/en active Active
- 2005-10-06 CN CN2005800336971A patent/CN101035559B/zh active Active
- 2005-10-06 MY MYPI20054709A patent/MY153290A/en unknown
- 2005-10-06 AU AU2005294322A patent/AU2005294322A1/en not_active Abandoned
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Also Published As
Publication number | Publication date |
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AP2007003955A0 (en) | 2007-07-30 |
ES2467094T3 (es) | 2014-06-11 |
WO2006041978A3 (en) | 2006-08-03 |
BRPI0516542B1 (pt) | 2015-11-17 |
JP2008515906A (ja) | 2008-05-15 |
MX2007004004A (es) | 2007-05-10 |
JP5105524B2 (ja) | 2012-12-26 |
KR20070059180A (ko) | 2007-06-11 |
TWI365074B (en) | 2012-06-01 |
BRPI0516542A (pt) | 2008-09-09 |
ZA200702876B (en) | 2008-09-25 |
NZ553975A (en) | 2010-04-30 |
KR101370464B1 (ko) | 2014-03-06 |
TW200617166A (en) | 2006-06-01 |
MY153290A (en) | 2015-01-29 |
CN101035559B (zh) | 2011-08-17 |
CA2581355A1 (en) | 2006-04-20 |
AR051636A1 (es) | 2007-01-31 |
AP2167A (en) | 2010-11-12 |
AU2005294322A1 (en) | 2006-04-20 |
EP1796720A2 (en) | 2007-06-20 |
US8067013B2 (en) | 2011-11-29 |
WO2006041978A2 (en) | 2006-04-20 |
EP1796720B1 (en) | 2014-04-23 |
US20060204976A1 (en) | 2006-09-14 |
CA2581355C (en) | 2016-01-26 |
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