CN101032538A - Method of preparing substances extracted from Gynura procumbens (Lour.) Merr. and the application - Google Patents
Method of preparing substances extracted from Gynura procumbens (Lour.) Merr. and the application Download PDFInfo
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- CN101032538A CN101032538A CN 200710051826 CN200710051826A CN101032538A CN 101032538 A CN101032538 A CN 101032538A CN 200710051826 CN200710051826 CN 200710051826 CN 200710051826 A CN200710051826 A CN 200710051826A CN 101032538 A CN101032538 A CN 101032538A
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Abstract
The present invention discloses one kind of gynura extract and its preparation process and application. The gynura extract is thick paste obtained with gynura herb and through water extracting and alcohol precipitating or alcohol extracting. The gynura extract contains total gynura alkaloid, total gynura flavone, organic acid and other chemical components. The gynura extract may be used in preparing medicine for treating hepatitis B and diabetes caused by hepatitis B beta cell injury.
Description
Technical field
The present invention relates to a kind of Gynura procumbens (Lour.) Merr. method for preparing extractive and application thereof.
Background technology
At present, the whole world nearly more than 400,000,000 B-mode hepatitis A viroid (HIV) chronic infection persons.Therefore China's statistics year by year has the chronic infection person of HIV more than 200,000,000 approximately, and the research and development to the medicine of anti-hepatitis virus are very necessary.
Gynura procumbens (Lour.) Merr. is Compositae, Radix Notoginseng platymiscium, Herba Gynurae procumbentis, Gynura procumbcns (Lour) morr, be the perennial herb medicine food dual purpose plant, diseases such as this plant treatment traumatic injury of usefulness among the people, rheumatic arthritis, bronchitis, pneumonia, nephritis; " China's book on Chinese herbal medicine " record Gynura procumbens (Lour.) Merr. has dredge the meridian passage, diffusing silt detumescence, bronchitis, pneumonia, pulmonary tuberculosis, toxic swelling pain skin ulcer that better curative effect is arranged.In recent years, find that abroad this plant has curative effect preferably to acute coryza, erythra, nephropathy, hypertension, diabetes.
Summary of the invention
Purpose of the present invention just provides a kind of Chinese herbal medicine Gynura procumbens (Lour.) Merr. method for preparing extractive, and the application of Gynura procumbens (Lour.) Merr. extract in hepatitis B, the caused diabetes of hepatitis B β cell injury.
Gynura procumbens (Lour.) Merr. preparation method of extract of the present invention is: 95% methanol or the alcoholic solution that Gynura procumbens (Lour.) Merr. herb coarse powder are added 8～10 times of amounts, being heated to boiling reflux extracted 2-4 hour, solid-liquid separation behind the recovery solvent, must not have the heavy paste extract of alcohol flavor.
Gynura procumbens (Lour.) Merr. preparation method of extract of the present invention is: the decocting that Gynura procumbens (Lour.) Merr. herb coarse powder is added 8～10 times of amounts boiled 2-4 hour, solid-liquid separation, evaporating water, add 95% ethanol again and measure 65% to containing alcohol, precipitation is spent the night, filter, behind the recovery solvent, must not have the heavy paste extract of alcohol flavor.
The Gynura procumbens (Lour.) Merr. extract of above-mentioned preparation method preparation can be used for preparing in the medicine of treatment hepatitis B and the caused diabetes of hepatitis B β cell injury.
The Gynura procumbens (Lour.) Merr. extract is carried out The Chemical Constituents to be shown: Gynura procumbens (Lour.) Merr. contains number of chemical compositions such as various volatile oil, yellow cave glycosides, alkaloid, organic acid (chlorogenic acid and derivant 3～5-dioxygen-caffeoylquinic acids thereof and 4～5-dioxygen-caffeoylquinic acids) and hydroxyl lactic acid.
Pharmacological evaluation shows: Gynura procumbens organic acid has therapeutical effect preferably to the bleb disease that caused by virus, erythra etc.And yellow cave constituents: kaempferol-3-O-glucoside, cage for wild beasts skin element ,-3-O-rhamnose (1-6) glucoside, Pi Su ,-3-O-rhamnose (1-6) galactoside, kaempferol-3-O-rhamnose (1-6) glucoside etc. have the remarkable effect of repairing pancreatic beta cell and blood sugar lowering concentration preferably, and its alkaloids composition has stronger antibiotic analgesic effect.
The extracorporeal bacteria inhibitor test of Gynura procumbens (Lour.) Merr. extract shows: Gynura procumbens (Lour.) Merr. all has in various degree inhibitory action to staphylococcus aureus and Resistant strain, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, escherichia coli, pseudomonas aeruginosa etc.Simultaneously hepatitis B virus, influenza virus there is antivirus action preferably.
Gynura procumbens (Lour.) Merr. method for preparing extractive of the present invention is simple, easy to operate, and prepared extract cocoa is used for the treatment of hepatitis B and the caused diabetes of hepatitis B β cell injury.
The specific embodiment
Embodiment 1:
With 95% methanol or the alcoholic solution of 8～10 times of amounts of Gynura procumbens (Lour.) Merr. herb coarse powder adding, be heated to boiling reflux and extracted 2-4 hour, solid-liquid separation behind the recovery solvent, must not have the heavy paste extract of alcohol flavor.
Embodiment 2:
The decocting that Gynura procumbens (Lour.) Merr. herb coarse powder is added 8～10 times of amounts boiled 2-4 hour, solid-liquid separation, evaporating water adds 95% ethanol again and measures 65% to containing alcohol, precipitation is spent the night, and filters, reclaim solvent after, must not have the heavy paste extract of alcohol flavor.
Claims (4)
1, a kind of Gynura procumbens (Lour.) Merr. preparation method of extract, it is characterized in that: 95% methanol or the alcoholic solution that the steps include: Gynura procumbens (Lour.) Merr. herb coarse powder is added 8～10 times of amounts, being heated to boiling reflux extracted 2-4 hour, solid-liquid separation, after reclaiming solvent, must there be the heavy paste extract of alcohol flavor.
2, a kind of Gynura procumbens (Lour.) Merr. preparation method of extract, it is characterized in that: the steps include: that the decocting that Gynura procumbens (Lour.) Merr. herb coarse powder is added 8～10 times of amounts boiled 2-4 hour, solid-liquid separation, evaporating water, add 95% ethanol again and measure 65% to containing alcohol, precipitation is spent the night, and filters, after reclaiming solvent, must there be the heavy paste extract of alcohol flavor.
3, the Gynura procumbens (Lour.) Merr. extract as claim 1 or 2 preparations is preparing the application for the treatment of in the hepatitis B medicament.
4, the Gynura procumbens (Lour.) Merr. extract as claim 1 or 2 preparations is preparing the application for the treatment of in the caused diabetes medicament of hepatitis B β cell injury.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200710051826 CN101032538A (en) | 2007-04-08 | 2007-04-08 | Method of preparing substances extracted from Gynura procumbens (Lour.) Merr. and the application |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200710051826 CN101032538A (en) | 2007-04-08 | 2007-04-08 | Method of preparing substances extracted from Gynura procumbens (Lour.) Merr. and the application |
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| CN101032538A true CN101032538A (en) | 2007-09-12 |
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| CN 200710051826 Pending CN101032538A (en) | 2007-04-08 | 2007-04-08 | Method of preparing substances extracted from Gynura procumbens (Lour.) Merr. and the application |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520244A (en) * | 2013-11-06 | 2014-01-22 | 唐和斌 | Application of gynura procumbens extracts to preparation of liver injury prevention and cure preparations |
| CN104621565A (en) * | 2015-02-11 | 2015-05-20 | 中南林业科技大学 | Processing method of gelled food with gynura procumbens |
| CN106290648A (en) * | 2016-08-31 | 2017-01-04 | 天津市中升挑战生物科技有限公司 | The assay method of aureine alkaloid in a kind of Radix gynurae segeti superfine powder |
| CN106490614A (en) * | 2016-10-31 | 2017-03-15 | 北京万源普达医疗科技有限公司 | A kind of composition and its application as diabetes full nutrition formula food |
| CN106727824A (en) * | 2016-12-30 | 2017-05-31 | 天津市中升挑战生物科技有限公司 | The preparation method and application of chrysanthemum leaf Notogineng Extract and its compound preparation |
| CN106924317A (en) * | 2015-12-30 | 2017-07-07 | 北京万源普达医疗科技有限公司 | The preparation method and Traditional Chinese medicine for decreasing blood sugar preparation of a kind of Gynura procumbens (Lour.) Merr extract |
| CN106924315A (en) * | 2015-12-30 | 2017-07-07 | 北京万源普达医疗科技有限公司 | The preparation method and Traditional Chinese medicine for decreasing blood sugar preparation of a kind of Gynura procumbens (Lour.) Merr extract |
| CN107245412A (en) * | 2017-08-08 | 2017-10-13 | 广西桂平市石龙镇江夏种养专业合作社 | A kind of litchi spirit and preparation method thereof |
| CN107312691A (en) * | 2017-06-09 | 2017-11-03 | 韦朝胜 | A kind of fresh kidney beans wine and preparation method thereof |
| CN107751652A (en) * | 2017-11-29 | 2018-03-06 | 孙铭岐 | A kind of grouper phagostimulant |
| CN107951915A (en) * | 2017-12-12 | 2018-04-24 | 江西天元药业有限公司 | For improving cardiovascular raising immunity and antitumor Gynura procumbens (Lour.) Merr extract |
| CN115887318A (en) * | 2022-11-08 | 2023-04-04 | 浙江中医药大学 | Gynura segetum alcohol extract and application thereof |
-
2007
- 2007-04-08 CN CN 200710051826 patent/CN101032538A/en active Pending
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103520244B (en) * | 2013-11-06 | 2015-05-20 | 唐和斌 | Application of gynura procumbens extracts to preparation of liver injury prevention and cure preparations |
| CN103520244A (en) * | 2013-11-06 | 2014-01-22 | 唐和斌 | Application of gynura procumbens extracts to preparation of liver injury prevention and cure preparations |
| CN104621565A (en) * | 2015-02-11 | 2015-05-20 | 中南林业科技大学 | Processing method of gelled food with gynura procumbens |
| CN104621565B (en) * | 2015-02-11 | 2016-08-24 | 中南林业科技大学 | A kind of processing method of Gynura procumbens (Lour.) Merr. gel food |
| CN106924315A (en) * | 2015-12-30 | 2017-07-07 | 北京万源普达医疗科技有限公司 | The preparation method and Traditional Chinese medicine for decreasing blood sugar preparation of a kind of Gynura procumbens (Lour.) Merr extract |
| CN106924317A (en) * | 2015-12-30 | 2017-07-07 | 北京万源普达医疗科技有限公司 | The preparation method and Traditional Chinese medicine for decreasing blood sugar preparation of a kind of Gynura procumbens (Lour.) Merr extract |
| CN106290648A (en) * | 2016-08-31 | 2017-01-04 | 天津市中升挑战生物科技有限公司 | The assay method of aureine alkaloid in a kind of Radix gynurae segeti superfine powder |
| CN106490614A (en) * | 2016-10-31 | 2017-03-15 | 北京万源普达医疗科技有限公司 | A kind of composition and its application as diabetes full nutrition formula food |
| CN106727824A (en) * | 2016-12-30 | 2017-05-31 | 天津市中升挑战生物科技有限公司 | The preparation method and application of chrysanthemum leaf Notogineng Extract and its compound preparation |
| CN107312691A (en) * | 2017-06-09 | 2017-11-03 | 韦朝胜 | A kind of fresh kidney beans wine and preparation method thereof |
| CN107245412A (en) * | 2017-08-08 | 2017-10-13 | 广西桂平市石龙镇江夏种养专业合作社 | A kind of litchi spirit and preparation method thereof |
| CN107751652A (en) * | 2017-11-29 | 2018-03-06 | 孙铭岐 | A kind of grouper phagostimulant |
| CN107951915A (en) * | 2017-12-12 | 2018-04-24 | 江西天元药业有限公司 | For improving cardiovascular raising immunity and antitumor Gynura procumbens (Lour.) Merr extract |
| CN115887318A (en) * | 2022-11-08 | 2023-04-04 | 浙江中医药大学 | Gynura segetum alcohol extract and application thereof |
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Open date: 20070912 |