CN101028363A - Use of plant or herb and its volatile oil extract in preparation of medicine for treating diabetes - Google Patents
Use of plant or herb and its volatile oil extract in preparation of medicine for treating diabetes Download PDFInfo
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Abstract
An application of the volatile oil containing d-lemonene and extracted from such plants as lemon, orange, Chinese prickly ash, lemongrass herb, nutgrass fastsedge, etc and such Chinese-medicinal materials as tangerine peel, immature bitter orange, ginger, mint, fennel anise, myrrh, etc in preparing the medicines for treating diabetes is disclosed.
Description
The rue family citrus plant that technical field the present invention relates to contain compound d-limonene comprises fruit, peel, leaf and seed and the extractive of volatile oil thereof of plants such as Fructus Citri Limoniae, Fructus Citri tangerinae, Fructus Citri sinensis, Citrus aurantium Linn., Mauritius papeda, oily orange; The extractive of volatile oil of rutaceae Pericarpium Zanthoxyli, grass Herba Cymbopogonis, ericad Hemerocallis citrina Baroni Cuculus polioephalus, sedge dried tuber, Rhizoma et radix valerianae, leguminous plant alfalfa, rutaceae Acronychi apedunculata (L.) Miq., labiate Scabrous Mosla Herb, labiate Lemon Basil; The medical usage of Chinese medicine Pericarpium Citri Reticulatae, Pericarpium Citri Reticulatae Viride, Fructus Citri Sarcodactylis, Fructus Aurantii Immaturus, Rhizoma Et Radix Notopterygii, Rhizoma Zingiberis Recens, Folium Perillae, Flos Magnoliae, Radix Bupleuri, Herba Menthae, Herba Houttuyniae, Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Herba Glechomae, Fructus Foeniculi, Fructus Aurantii, Fructus cari carvi, Herba Schizonepetae, Folium Artemisiae Argyi, Strobilus Pini, Herba Erigerontis, Herba Artemisiae Annuae, Herba rutae, Fructus Litseae, Fructus Anisi Stellati, Fructus Carpesii, Herba Pogostemonis, Myrrha and Fructus Amomi etc. and extractive of volatile oil thereof, relate in particular to new purposes, be specifically related to the new purposes aspect the medicine of preparation treatment diabetes at pharmaceutical field.
The fresh mature peel that background technology prior art and knowledge disclose rutaceae Fructus Citri Limoniae Citrus limon (L.) Burm.f. contains volatile oil, and the Main Ingredients and Appearance in the volatile oil is a limonene, approximately reaches more than 90%.Also all contain limonene in the volatile oil of following plant:
The fresh mature fruit of rutaceae Fructus Citri Limoniae Citrus limon (L.) Burm.f. and variety thereof and peel (Pericarp), the perhaps fresh mature peel of rutaceae Fructus Citri tangerinae Citrus reticulata Blanco and variety thereof or dry mature skin (Chinese medicine Pericarpium Citri Reticulatae pericarpium Citri Reticulatae), or the peel of dry young fruit or immature fruit (Chinese medicine Pericarpium Citri Reticulatae Viride pericarpium Citri Reticulatae Viride), or the fresh mature fruit of Fructus Citri sinensis C.aurantium, peel and seed (seed), the perhaps fresh mature peel of Citrus aurantium Linn. Citrus aurantium, the perhaps peel of the dry young fruit of Citrus aurantium Linn. Citrus aurantium and variety thereof or Fructus Citri sinensis C.aurantium (Chinese medicine Fructus Aurantii Immaturus Fructus Aurantii Immaturus), perhaps fresh mature fruit and the peel of Mauritius papeda C.hystrix, perhaps fresh mature fruit and the peel of oily orange C.bergamia, perhaps fresh mature peel or the dry peel of rutaceae Fructus Citri Sarcodactylis Citrus medica L.Var Sarcodactylis Swingle, perhaps samphire Rhizoma Et Radix Notopterygii Notopterygium incisum Ting ex H.T.chang or Radix et Rhizoma Notopterygii N.forbesii Boiss rhizome and root, the perhaps fresh rhizome of zingiber Zingiber officinale (Willd) Rosc., the perhaps root of Folium Perillae Perilla frutescens (L.) Britt., perhaps Magnoliacea plant YULAN M.denudate Desr.[M.heptapeta (Buch.) Dandy; M.conspicua Salisb; M.yulan Desr.] or the dry flower of Flos Magnoliae M.sprengeri Pamp. (Chinese medicine Flos Magnoliae Flos Magnoliae), the perhaps dry aerial parts of Herba Schizonepetae Schizonepeta tenuifolia Briq, perhaps samphire Radix Bupleuri Bupleurum ChinenseDC. or Radix Bupeuri Scorzonerfolii. B.scorzonerifolium Willd (B.falcatum L.var.scorzonerifolium Ledeb.) (bupleurum Chinese Radix Bupleuri), or the dry root of Japanese Bupleurum falcatum B.falcatum L. (B.scorzonerifolium willd var.stenphyllum Nakai), the perhaps herb of labiate Herba Menthae Mentha haplocylyx Briq. (M.arvensis L.var haplocalyx Briq.) and tame Herba Menthae Mentha haplocalyx Briq.Var piperasoens (Malinvand) C.Y.Wu et H.W.Li (M.arvensisL.var.piperascens Malinvaud.), the perhaps herb of saururaceae plant houttuynia cordata Houttuynia cordata Thunb. (Chinese medicine Herba Houttuyniae Herba Houttuyniae), the perhaps head inflorescence of feverfew Herba Dendranthematis indici Chrysanthemum indicum L., the perhaps dry rattan of Piperaceae plant Radix seu Caulis fici Martinii Piper kadsura (choisy) Ohwi and Caulis et Folium piperis Piper walli chii (Miq) Hand-Mass (Chinese medicine Caulis Piperis Kadsurae Caulis Piper Kadsurae), the perhaps dry aerial parts of labiate HUOXUEDAN Glechoma longituba (Nakai) Kupr. (Chinese medicine Herba Glechomae Herba Glechomae), the perhaps dry mature skin of rutaceae green pepper Zanthoxylum schinifolium Sieb.Et Zucc. or Pericarpium Zanthoxyli Zanthoxylum bungeanum Maxim or pericarpium Zanthoxyli Z.simulans Hance, the perhaps dry mature fruit of samphire Fructus Foeniculi Foeniculum vulgare Mill. (Chinese medicine Fructus Foeniculi Fructus Foeniculi), the perhaps immature fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L. (Chinese medicine Fructus Aurantii FructusAurantii) and variety thereof, the perhaps fruit of samphire caraway Carum carri L. (Chinese medicine Fructus cari carvi Fructus cari carvi), the perhaps herb of Chenopodiaceae Chenopodium plant Herba Chenopodii Chenopodium ambrosioides L., the perhaps dried leaves of feverfew Chinese mugwort Artemisia argyi Le vl.et Vant., the perhaps herb of grass Herba Cymbopogonis CymbopogonDistans (Nees) A.Camus, the perhaps cone (cones) of pinaceae plant lacebark pine Pinus bungeana Zucc. (Chinese medicine Strobilus Pini Strobilus Pini Bungeanae), perhaps ericad Hemerocallis citrina Baroni Cuculus polioephalus Rhododendronanthopogonoides Maxim., the perhaps dry herb of Compositae Herba Erigerontis aceris platymiscium Erigeron breviscapus (Vant.) Hand.-Mazz. Erigeronbreviscapus (Vant.) Hand.-Mazz (Chinese medicine Herba Erigerontis Herba Erigeronis Breviscapi), the perhaps herb of feverfew Herba Artemisiae annuae Artemisia annua L. (Chinese medicine Herba Artemisiae Annuae Herba Artemisiae Annuae), or the herb of Rutaceae Folium Symplocoris Caudatae platymiscium Folium Symplocoris Caudatae Ruta graveolens L. (Chinese medicine Herba rutae Herba Rutae), or the dry mature fruit of canella cubeb litsen tree Litseacubeba (Lour.) Pers. (Chinese medicine Fructus Litseae Fructus Litseae), the perhaps dry mature fruit of Magnoliacea plant Fructus Anisi Stellati Illicium verum Hook.f., the perhaps dry mature fruit of feverfew Radix Carpesii Carpesium abranoides L. (Chinese medicine Fructus Carpesii Fructus Carpesii), the perhaps herb of labiate Herba Pogostemonis Pogostemon cablin (Blanco) Benth. or Herba Pogostemonis Agastache rugosus (Fisch.et Mey.) O.Ktze, perhaps sedge dried tuber Cyperusrotundus L. rhizome, the perhaps olive subject plant myrrh Commiphora myrrha Engl. trunk skin zone oleo-gum-resin of oozing out, perhaps zingiberaceous plant Fructus Amomi Amomum villosum Lour., sand A villosum Lour.Var.xanthioides T.L.Wuet Senjen contracts, the dry mature fruit of SEMEN AMOMI LONGILIGULA A.longiligulare T.L.Wu (Chinese medicine Fructus Amomi Fructus Amomi), the perhaps dry leaf of labiate Folium Perillae Perilla frutescens (L.) Britt., perhaps root and the rhizome of Valerianaceae plant Rhizoma et radix valerianae Valerianaofficnalis L. or Valeriana officinalis var. latifolia V.officinalis L.var.latifolia Miq, the perhaps herb of leguminous plant alfalfa Medicago Sadiva L. or medicago hispida Medicago hispida Guertn, the perhaps leaf of rutaceae Acronychi apedunculata (L.) Miq. Acronychia pedunculata (L) Miq or bauer acronychia A.baueri, the perhaps herb of labiate Scabrous Mosla Herb M.scabra (Thunb.) C.Y.Wu et H.W.Li, the perhaps leaf of labiate Lemon Basil Ocimum basilicum var.citriodorum.(Wang Wangxiang, modern Chinese medicine pharmacology, Tianjin science tech publishing house, Chinese edition, 1997)
Wherein:
Mainly contain the d-limonene in the volatile oil of Chinese medicine Pericarpium Citri Reticulatae, content is more than 80%;
Mainly contain the d-limonene in the volatile oil of Chinese medicine Pericarpium Citri Reticulatae Viride, content is more than 80%.
Mainly contain d-limonene, content about 90% in the volatile oil of Fructus Citri sinensis;
Mainly contain d-limonene, content about 90% in the volatile oil of Citrus aurantium Linn.;
Mainly contain d-limonene, content about 90% in the volatile oil of Chinese medicine Fructus Aurantii Immaturus;
Mainly contain the d-limonene in the volatile oil of Chinese medicine Fructus Aurantii, content is more than 90%;
Mainly contain d-limonene, content about 86% in the volatile oil of rutaceae grapefruit;
Mainly contain the d-limonene in the volatile oil of Mauritius papeda c.hystrix, more than the content 80-90%;
Mainly contain the d-limonene in the volatile oil of the orange C.bergamia of oil, more than the content 80-90%;
Contain the d-limonene in the Chinese medicine Fructus Citri Sarcodactylis volatile oil, content about about 50%;
Contain the d-limonene in the Chinese medicine Rhizoma Et Radix Notopterygii volatile oil, about the about 11-34% of content;
Contain the d-limonene in the Chinese medicine Folium Perillae volatile oil, content 10-30%;
Contain the d-limonene in the Chinese medicine Flos Magnoliae volatile oil, content 10%;
Contain the d-limonene in the Chinese medicine Pericarpium Zanthoxyli volatile oil, content about 25%;
Contain the d-limonene in the Chinese medicine Folium Artemisiae Argyi volatile oil, content 15%;
Contain the d-limonene in the Chinese medicine Fructus Foeniculi volatile oil, content 13.1%;
Contain the d-limonene in the Chinese medicine Fructus Litseae volatile oil, content 11.6%;
Prior art and knowledge disclose the chemical compound limonene (Cyclohexene, 1-methyl 4-(1-methylethenyl)-, (+)-(R)), i.e. 1-methyl 4-(1-methyl ethylene) cyclohexene.The molecular formula of this chemical compound is C10H16, and molecular weight is 136.32, and liquid is water insoluble, is soluble in ethanol.Limonene has the d-limonene, 1-limonene, three kinds of optical isomers of dl-limonene or dipentene.
The chemical name of d-limonene is (4R)-(+)-4-isopropenyl-1-methylcyclohexene.It is present in orange peel oil, Fructus Citri Limoniae oil, oleum bergamottae, dill oil and the Fructus Citri tangerinae wet goods.178 ℃ of boiling points, 61 ℃ (1.60kPa).Relative density is 0.8411.
The l-limonene exists less in the mandarin orange quintessence oil, but can be transformed from other aromatics.It is present in Russian Oleum Terebinthinae, the cajeput oil etc.Boiling point 177.6-177.8 ℃ (100.7kPa), 64.4 ℃ (2.0kPa).Relative density is 0.8422.
The dl-limonene is present in Siberia Folium Pini oil, Indian oil of verbena, the Rhizoma et radix valerianae wet goods, 178 ℃ of boiling points, 64.4 ℃ (2.0kPa), relative density is 0.8402.
The three is the oily liquids with NINGMENGXIANG.Under normal pressure, distill and do not change, but in air easily oxidation generate complex mixtures such as oxygenatedchemicals and polymer, 48 ℃ of flash-points.
Limonene mainly as the solvent of enamel paint, varnish and various oleo-resins, resin wax, metal drier, is used to make synthetic resin and synthetic rubber.Be used for daily essences such as food, detergent, still can prepare edible artificial citrus oils, as the prescription of Fructus Citri tangerinae flavor essence.U.S. Pat 4,083,994 disclose the d-limonene can be as the active component of choleretic.
Diabetes are diseases of a kind of complexity, it is characterized by hyperglycemia.This disease can be divided into two main subclass: insulin-dependent (IDDM), be also referred to as type 1 diabetes, and non-insulin-depending type (NIDDM), be also referred to as type 2 diabetes mellitus.(World Health Organization's diabetes study group, WHO technology series report 844,1994).
Type 1 diabetes forms when the immune system of body has been destroyed beta Cell of islet, and this cell is the cell of the hormone insulin of manufacturing blood sugar regulation unique in body.Type 1 diabetes may account for the 5-10% of the diabetes of all having diagnosed
Type 2 diabetes mellitus may account for the 90-95% of the diabetes of all having diagnosed.It has insulin resistant when beginning usually, a kind of disorder that can not fully utilize insulin with cell.When the needs insulin increased secretion, pancreas was lost the ability (Center for Disease Control of national sanitary portion, national diabetes fact sheet, 2003) that it produces insulin gradually.
1 type and type 2 diabetes mellitus can both cause complication blood capillary, trunk and neuropathy.Diabetes can influence the mass part of body, and can cause serial complication for example to resemble blind, kidney injury and amputation.
1998, the report of World Health Organization (WHO) pointed out that global at that time diabetics is 1.48 hundred million.
Nineteen ninety-five, the investigation of carrying out in China 40,000 multidigit cities of 11 provinces and cities and urban residents finds, diabetes prevalence from 1980 0.69% be increased to 3.21%.Estimate that patient's total number of persons reaches nearly 3,600 ten thousand.(Xiang Hongding, Wu Wei, Liu Canqun, etc., national diabetes epidemiology characteristics baseline investigation report in 1996, Chinese diabetes magazine, 1998,6:131-133.)
In the U.S., there are 1,820 ten thousand people that diabetes are arranged, account for 6.3% of population.2002, in the U.S., the total cost of diabetes was 1,320 hundred million dollars (comprising flat cost and overhead cost), and directly medical expense is 92,000,000,000 dollars, and indirect expense is 40,000,000,000 dollars (comprising permanent disability, disablement and premature dead).(Center for Disease Control of national sanitary portion, national diabetes fact sheet, 2003).
At present, the medicine of the type 2 diabetes mellitus of treatment mainly contains following a few class:
1. biguanides.Curative effect is low, and side effect is bigger, for a long time with the normal lactic acidosis that produces.
2. sulphur is urinated the class medicine.Side effect is bigger, for a long time with the normal hypoglycemia that produces.And it is tired that the pancreas island is taken place, even depleted, and endogenic insulin secretion function further reduces, and the medicine secondary failure takes place.
3. acarbose class medicine.Only postpone the absorption of glucose, reduce level of postprandial blood sugar at small intestinal.It can not stimulate secretion of insulin, can not change fasting insulin and C peptide level.
4. above-mentioned these medicines cooperate insulin or make the insulinize type 2 diabetes mellitus separately, and final endogenic insulin secretion function will completely lose, and the dependency of insulin will be come (World Health Organization's diabetes study group eventually.WHO technology series report 844,1994).
Above-mentioned all medicines all have the effect of more intense and persistent blood sugar lowering, but blood sugar lowering level stably.Simultaneously, patient will need to strengthen year by year the therapeutic dose of these medicines.Britain's diabetes perspective study points out that all medicines all can not prevent fasting plasma glucose level persistence to rise, and show that islet cell function carries out sexual exhaustion.(Britain's diabetes perspective study group, Britain's diabetes perspective study, 1977-1992)
Therefore diabetes are called as the disease of none example treatment recovery from illness still in the world, and at present, all medicines all can not be discontinued medication.
Prior art and knowledge disclose Chinese medicine Radix Ginseng Radix Ginseng (root of Araliaceae Radix Ginseng Panax ginseng C.A.Mey.), Rhizoma Polygonati Odorati Rhizoma Polygonati Odorati (liliaceous plant Rhizoma Polygonati Odorati Polygonatum odoratum (Mill.) Druce rhizome), Radix Glycyrrhizae Radix Glycyrrhizae (root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch. or Glycyrrhiza inflata Bat. G.inflate Bat. or Glycyrrhiza glabra L. G.glabra L.), Cortex Lycii Cortex Lycii (root bark of matrimony vine of solanaceae plant Lyciumchinense Mill. or lycium barbarum Lycium barbarum L.), Rhizoma Atractylodis Rhizoma Atractylodis (feverfew Atractylodes lancea (Thunb.) DC. Atracylodes lancea (Thunb.) D.C. or Atractylis chinensis A.chinensis (D.C.) Koidz. rhizome), Rhizoma Atractylodis Macrocephalae Rhizoma Atractylodis Macrocephalae (feverfew Rhizoma Atractylodis Macrocephalae Atractylodes macrocephala Koidz. rhizome), Rhizoma Anemarrhenae Rhizoma Anemarrhenae (liliaceous plant Rhizoma Anemarrhenae Anemarrhena asphodeloides Bunge rhizome), Semen Litchi Semen Litchi (seed of sapindaceous plant Fructus Litchi Litchi chinensis Sonn.), Folium Mori Folium Mori (leaf of moraceae plants Mulberry Morus alba L.), Rhizoma Coptidis Rhizoma Coptidis (cohosh Rhizoma Coptidis Coptis chinensis Franch. or Coptis deltoidea C.Y.Cheng et Hsiao C.deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall C.teeta wall. rhizome), Rhizoma Polygonati RhizomaPolygonati (liliaceous plant Yunnan Rhizoma Polygonati Polygonatum kingianum Coll.et Hemsl. or Rhizoma Polygonati P.sibiricum Red. or Polygonatum cyrtonema Hua P.cyrtonema Hua rhizome), Herba Epimedii Herba Epimedii (aerial parts of Berberidaceae plant Herba Epimedii Epimediumbrevicornum Maxim. or arrow leaf Herba Epimedii E.sagittatum (Sieb.Et Zucc.) Maxim. or Herba Epimedii E.Koreanum Nakai), Radix Puerariae Radix Puerariae (root of legume pueraria lobata Pueraria lobata (Willd.) Ohwi or Radix Puerariae P.thomsonii Benth.) and Radix Arnebiae (Radix Lithospermi) Radix Arnebiae (root of comfrey lithospermum euchromum Royle Arnebiaeuchroma (Royle) JAohnst. or Radix Arnebiae (Radix Lithospermi) Lithospermum erythrorhizon Sieb.et Zucc.) and extract thereof etc. have the effect of blood sugar lowering, and side effect is less.But, in them, have the effect of enough powerful blood sugar lowering without any a kind of Chinese medicine.
Summary of the invention
The object of the present invention is to provide the above-mentioned plant that contains compound d-limonene, perhaps the new medical use of plant medical herbs or Chinese medicine.Be that they are at pharmaceutical field, in the application aspect the medicine of preparation treatment diabetes.The present invention finds that by zoopery and clinical observation contain the above-mentioned plant of d-limonene, perhaps plant medical herbs or Chinese medicine all have the effect of obvious and powerful blood sugar lowering separately.
The present invention finds in clinical observation that at first Chinese medicine Rhizoma Et Radix Notopterygii, Pericarpium Citri Reticulatae etc. have the effect of tangible reduction type 2 diabetes mellitus people post-prandial glycemia,
Fructus Citri Limoniae oil is observed in further research and Oleum Citri Reticulatae has more powerful blood sugar lowering effect.Final discovery pharmaceutically-active ingredients wherein is the main optical isomer d-limonene of chemical compound limonene.By zoopery, find compound d-limonene have reduce inductive 1 type of medicine STZ-and and the obvious effect of type 2 diabetes mellitus rat model blood glucose, the therapeutic effect highly significant.And contain the plant of limonene, medical herbs or Chinese medicine have many kinds, and the present invention determines to contain plant, medical herbs or Chinese medicine and the extractive of volatile oil thereof of compound d-limonene by following experiment, the same with the d-limonene, the effect of more powerful blood sugar lowering is also arranged.
From fruit, peel and the leaf of rue family citrus plant, extract the method for volatile oil and d-limonene:
Adopt the fresh mature peel of rutaceae Fructus Citri Limoniae Citrus limon (L.) Burm.f., perhaps adopt the fresh mature peel of rutaceae Fructus Citri tangerinae Citrus reticulata Blanco and variety thereof, or the fresh mature fruit of employing Fructus Citri sinensis C.aurantium, peel and seed (seed), perhaps adopt the fresh mature peel of Citrus aurantium Linn. Citrus aurantium, perhaps fresh mature fruit and the peel of Mauritius papeda C.hystrix, perhaps adopt fresh mature fruit and the peel of oily orange C.bergamia, perhaps adopt the fresh mature peel of rutaceae Fructus Citri Sarcodactylis Citrus medica L.Var Sarcodactylis Swingle etc., tear up directly cold pressing of back, through centrifugal or filtration, obtain volatile oil again.
Or employing rutaceae Fructus Citri tangerinae Citrus reticulata Blanco and the dry mature skin Pericarpium Citri Reticulatae pericarpium Citri Reticulatae of variety or the peel Pericarpium Citri Reticulatae Viride pericarpium Citri ReticulataeViride of dry young fruit or immature fruit, perhaps adopt the peel of the dry young fruit of Citrus aurantium Linn. Citrus aurantium and variety thereof or Fructus Citri sinensis C.aurantium (Chinese medicine Fructus Aurantii Immaturus FructusAurantii Immaturus), use the dry fruit skin, it is soft to add 8 parts of blisters with every part of peel, generally steeps 3-4h.
Perhaps, directly adopt fruit to get oil.Select the Citrus of cleaning for use, orange class is sent in the different oil grinding machines with Fructus Citri Limoniae class fruit and is got oil.Mainly contain FMC technology and Blang's technology (BOE), also have special oil grinding machine in some areas and country.
Quintessence oil removes terpene technology, 178 ℃ of boiling points, during 61 ℃ of (1.60kPa) fractional distillation, can separate obtaining the d-limonene.
Perhaps, behind other conventional method separation and purifications, can be with in the present invention.
Pressed oil and quintessence oil that the method for this cold pressing obtains can obtain purity at the d-limonene more than 90%.Further distillation is to remove aldehyde in rare NaOH or carbon back addition agent (example hydrochloric acid hydroxylamine), and then purity can reach 99.5%.
Extracting the method for volatile oil from Rhizoma Et Radix Notopterygii, Fructus Citri Sarcodactylis, Fructus Aurantii Immaturus, Rhizoma Zingiberis Recens, Folium Perillae, Flos Magnoliae, Radix Bupleuri, Herba Menthae, Herba Houttuyniae, Flos Chrysanthemi Indici, Caulis Piperis Kadsurae, Herba Glechomae, Fructus Foeniculi, Fructus Aurantii, Fructus cari carvi, Herba Schizonepetae, Folium Artemisiae Argyi, Strobilus Pini, Herba Erigerontis, Herba Artemisiae Annuae, Herba rutae, Fructus Litseae, Fructus Anisi Stellati, Fructus Carpesii, Herba Pogostemonis, Myrrha and Fructus Amomi Chinese medicines such as (it is characterized by oleaginous material are herb, rhizome, leaf, seed and the fruitlet of plant drying), mainly is the resulting and immiscible volatility oily of water composition with steam distillation.
In zoopery of the present invention, this product shows the obvious functions of blood sugar effect to drug-induced diabetes rat.Oral administration gives in laboratory animal Pericarpium Citri Reticulatae and extractive of volatile oil (7-8g/kg/ days) thereof back 0.5-2 hour, and the maximum reduction amplitude of animal blood slurry glucose can reach 50%～100%, and drug effect fades away after 2 hours in medication.
The present invention can reduce medicine (streptozotocin, streptozotocin) fasting glucose and the diabetic complication symptom of the severe type 2 diabetes mellitus rat model due to inducing.Give diabetes rat with Pericarpium Citri Reticulatae and the extractive of volatile oil filling stomach thereof of 7-8g/kg, after 0.5-2 hour, the blood glucose of experimental rat is dose dependent and descends.
In clinical experiment, the type 2 diabetes mellitus patient took Pericarpium Citri Reticulatae and extractive of volatile oil thereof, 12 weeks by a definite date after the meal in every day 3.The result shows that this medicine can obviously reduce medication person's blood sugar level after the meal.The speed of blood sugar lowering is quick, stable.
In clinical experiment, the type 2 diabetes mellitus patient took Rhizoma Et Radix Notopterygii and extractive of volatile oil thereof, 12 weeks by a definite date after the meal in every day 3.The result shows that this medicine can obviously reduce medication person's blood sugar level after the meal.The speed of blood sugar lowering is quick, stable, and still, effect is not as Pericarpium Citri Reticulatae.
Zoopery and clinical experiment result show, the present invention relates to contain the new medical usage of above-mentioned a series of plants, plant medical herbs or the Chinese medicine of compound d-limonene, find that said medicine has the effect of stronger blood sugar lowering, and these plants, plant medical herbs or Chinese medicine the effect of blood sugar lowering is arranged is never to report.
The present invention can contain one or more pharmaceutically acceptable carriers, it is the pharmaceutical carrier of pharmaceutical field routine, as water, starch, cellulose, gelatin, agar, powder-beta-dextrin, fabaceous lecithin or lecithin etc., medicine of the present invention can be by mode administration oral and injection.During oral administration, preferred form is tablet, coated tablet, granule, powder, soft capsule and suppository.The common dose of compound d-limonene of the present invention can be according to the order of severity of route of administration, conditions of patients, variations such as the type of diabetes, daily dose can be that Pericarpium Citri Reticulatae concentrates powder 3-6g (being equivalent to crude drug 18-36g), preferred every day dosage 4-5g.Have meal every day three times, divide and take for three times.The number of times of perhaps taking medicine is identical with the dining number of times.Take in 1-10 minute behind first mouthful of food inlet.
Use separately compound d-limonene, perhaps Fructus Citri Limoniae oil perhaps during Oleum Citri Reticulatae, has slight xerostomia phenomenon after part patient's medication; Giddy, weak, cardiopalmus, constipation or diarrhoea, herpes labialis etc. can appear in small number of patients, can disappear in decrement or drug withdrawal afterreaction.But use the Chinese medicine Pericarpium Citri Reticulatae contain capacity volatile oil, perhaps Rhizoma Et Radix Notopterygii etc. does not all have any significant side effects.Healthy people takes the above-mentioned any medicine that contains compound d-limonene separately, does not reduce after the meal or fasting blood glucose level.
The several embodiment of specific embodiment various details, but content of the present invention is not limited to this fully.
Detailed description of the invention
Embodiment 1
From above-mentioned fresh peel or dry peel, extract volatile oil, and therefrom extract the d-limonene: the fresh mature peel that adopts rutaceae Fructus Citri Limoniae Citrus limon (L.) Burm.f., directly send cold pressing in the squeezer after tearing up to, perhaps adopt the dry mature skin Pericarpium Citri Reticulatae pericarpium Citri Reticulatae of rutaceae Fructus Citri tangerinae Citrus reticulata Blanco and variety thereof, it is soft to add 8 parts of blisters with every part of peel, generally steeps 3-4h.
1. soak
Peel is immersed in 1.5～3.0% the lime water, keeps pH value 10～14, soak 6-10h, peel and lime water ratio are between 1: 4～6.The sclerosis peel makes it to be fit to squeezing.Outside the delime, soak and also can use sodium bisulfate, sodium carbonate, sodium sulfate etc.
2. clean
Peel is put into clear water flush away Calx and impurity.
3. squeezing
By squeezer the quintessence oil in the peel is extruded.
4. filter or separation
Oil water mixture from cold pressing expeller or squeezer come out has more peel residue, has indefinite stickiness, need filter and precipitation repeatedly, to alleviate the pressure of centrifugal separator.Filtering residue can reclaim quintessence oil through distillator.
5. centrifugalize
The high speed oil-water separator is adopted in the separation of profit, carries out oil-water separation.Separate finish after, should allow seperator idle running 2-3min, pour clear water in a large number, remaining oil is gone out.In order to impel quintessence oil from fat liquor, to separate, can add about 2% sodium hydroxide and a small amount of sodium sulfate in the water of oil expression usefulness.
6. make with extra care and dewaxing
Slight muddy thick quintessence oil is used anhydrous sodium sulfate dehydration, leaves standstill elimination residue, centrifugalize again behind the clear then.Muddy thick quintessence oil, through staticly settling, the reuse anhydrous sodium sulfate filters earlier.Precipitation residue, centrifugalize again.Thick quintessence oil placed under the low temperature leave standstill, after waxiness was separated out, the reuse centrifugal separation was removed.Under 8 ℃ of conditions, can separate out about 6d.Under-25 ℃, 2d can separate out.Adopt the Fructus Citri Limoniae peel can obtain purity and reach d-limonene 90% or more, the employing Pericarpium Citri Reticulatae can obtain the d-limonene that purity reaches 80-90%.
7. purify
The d-limonene that cold pressing obtains can be with the method for distilling under reduced pressure, and 178 ℃ of boiling points, 61 ℃ of (1.60kPa) fractional distillation obtain purity and reach about 99% d-limonene from distillator.Further distillation is to remove aldehyde in rare NaOH or carbon back addition agent (example hydrochloric acid hydroxylamine), and then purity can reach 99.5%.But the d-limonene that purification is later if do not protected, then can react by very fast and airborne oxygen, and being converted into purity is the thick d-limonene of 95-96%.
8. volatile oil d-limonene is made the tablet that can take
Volatile oil and a certain amount of powder-beta-dextrin is mixed in the mode of spraying, add a certain amount of water, keep at a certain temperature, stir 1h, 24h is placed in cold preservation, filters, drains, adding a small amount of ether washing 2 times, is powder in drying below 50 ℃, adds the water of capacity again.The rate of charge of volatile oil and β-CD be 1: 9 (ml: g), mixing speed 100r/min, comprising temperature is 40 ℃, powder-beta-dextrin is 1: 7 with the ratio that adds entry.
Embodiment 2
The experiment of type 2 diabetes mellitus rat model
The foundation of type 2 diabetes mellitus rat experiment model.Adopt the model of the similar NIDDM of anaphylactic type.One time capacity gives animal Wistar rat streptozotocin (STZ), causes the B cell to damage in a large number, and the synthetic and secretion of insulin reduces, and causes carbohydrate metabolism disturbance, causes diabetes.STZ with fresh 2% the solution of being mixed with of the minor official sour sodium buffer of the aseptic Chinese holly of 0.1mol/L, is regulated pH value to 4.5, the bacteria filter filtration sterilization.50-65mg/kg tail vein shot solution was pressed in the rat fasting in 18 hours, and 24 hours blood glucose promptly can be used as successfully model more than or equal to 13.0mmol/L (perhaps 16.7mml/L).
The common single dose of this anaphylactic type model reaches the 50mg/kg body weight and the natural remission phenomenon do not occur, and 6-27 days, islets of langerhans had to a certain degree regeneration, and funtion part is recovered, but does not reach normal, still is in hyperglycemia state, is suitable for the correlational study of NIDDM.Streptozotocin is injected in back 10 hours and is given rat feeding 10% glucose, to prevent hypoglycemia.In relevant experiment, STZ is dissolved into 0.1M citric acid-sodium citrate buffer (PH4.2) to form 60-65mg/kg weight solution, and solution is injected into the tail vein immediately.After 10 days, after determining the abundant height of check blood sugar level, experiment material is given.Treated 7 days, and used canonical procedure to obtain blood from animal, the SureStep blood glucose machine of a blood glucose monitoring system Johson ﹠ Johnson is used in measurement of glucose levels.
In relevant method for breeding, use 7 all big male Wistar rats (weight 210 ,+-.10g) 12 every group.Mouse is raised humidity 50% and illumination-dark each 12 hours (the about 19:00 of 7:00) under room temperature 22 degree Celsius.Ad lib and drinking-water.Every day is in fasting after 4 hours, adds Pericarpium Citri Reticulatae and extractive of volatile oil enters in the mouse body with 5g/kg (being equivalent to crude drug 30g/kg) body wt in the mode of irritating stomach.Irritated behind the stomach 2 hours, and, checked its blood sugar level from the rat tail vein blood drawing.
Experimental result as shown in Table 2, t＞0.001, there are the difference of highly significant, curative effect highly significant in P＜0.01.Illustrate that medicine Pericarpium Citri Reticulatae and volatile oil thereof can obviously reduce the fasting glucose of type 2 diabetes mellitus rat model.
Compare before and after the treatment of table 1:2 type diabetes model rat (x ± S)
| Number of animals | Fasting glucose | Medicine (g/kg) | |
| Before the treatment | 10 | 25.94±2.281 | |
| After the treatment | 10 | 19.15±4.952 | Pericarpium Citri Reticulatae and volatile oil 5g |
| t | 3.938 | ||
| p | ＜0.01 |
Embodiment 3:
The type 1 diabetes rat experiment
The foundation of type 1 diabetes rat experiment model.Recent years, more people have clearly expressed and have observed the inductive experiment diabetes model of STZ-, though it is 1 pattern type in principle, may be used for as same 2 pattern types.In any case, because the inductive experiment diabetes model of STZ-mouse 1-6 days after morbidity, the similar type 1 diabetes that depends on insulin, further research is to go to detect blood sugar level carefully.
The inductive diabetes rat of STZ-, in injection 3-6 days behind the STZ, every day is in fasting after 4 hours, adds Pericarpium Citri Reticulatae and extractive of volatile oil enters in the mouse body with 7.2g/kg (being equivalent to crude drug 43g/kg) body wt in the mode of irritating stomach.Irritated behind the stomach 2 hours, and, checked its blood sugar level from the rat tail vein blood drawing.
Experimental result shows that the Oleum Citri Reticulatae that contains limonene has obvious therapeutic effect to the type 1 diabetes rat model.(table 2 of face as follows)
The comparison of table 2 IDDM group and Pericarpium Citri Reticulatae and extractive of volatile oil treatment group blood sugar level thereof (x ± S)
| Group | Number of animals | Blood glucose (mmol/l) | ||||
| The 1st day | Second day | The 3rd day | The 4th day | Gathered in 1-4 days | ||
| The IDDM group | 12 | 25.27±2.632 | 27.36±1.243 | 26.08±3.896 | 25.97±2.966 | 26.17±2.858 |
| The treatment group | 11 | 22.72±7.934 | 23.78±5.430 | 21.44±7.006 | 22.24±6.386 | 22.54±6.567 |
| t | 1.054 | 2.493 | 1.987 | 1.823 | 3.490 | |
| p | ＞0.05 | ＜0.05 | ＞0.05 | ＞0.05 | ＜0.01 | |
Embodiment 4
One male patient, 56 years old, type 2 diabetes mellitus.Fasting glucose is in normal range, and post-prandial glycemia is in 15.6mmol/L (281mg/dl) scope.After 4-6 hour after the meal, do not have feed, hypoglycemia often takes place.Treat in preceding 15 days and do not use any medicine, by 7 days treatment, every day breakfast, lunch and dinner, at first mouthful in 5-10 minute after meal, orally give Fructus Citri Limoniae oil 1ml, blood glucose peak-peak 11.8mmol/L (212mg/dl) is at 1.25h after breakfast.Continue 12 weeks of treatment, blood glucose peak-peak 10.4mmol/L (212mg/dl) is advanced to 0.75h after breakfast.After the dinner, refuse to obey any medicine, post-prandial glycemia is in normal range.After the lunch, do not take medicine post-prandial glycemia or in normal range, perhaps blood sugar level is high slightly.But breakfast still can not drug withdrawal.After 6-8 hour after the meal, there is not feed, no hypoglycemic reaction.Patient keeps the medium diet of appropriateness during this period.(annotate: the contained d-limonene of Chinese Pharmacopoeia content is 90%, therefore, can be considered as the d-limonene to Fructus Citri Limoniae oil (d-limonene content is 90%))
This patient tested preceding 3 months at this, and every meal employing Rhizoma Et Radix Notopterygii 2g (crude drug 12g) treats and reaches 1 month, reduces post-prandial glycemia more stablely.In the one and a half months subsequently, change Pericarpium Citri Reticulatae 2g (crude drug 12g)/every meal, lunch and dinner post-prandial glycemia are in normal range, and only breakfast blood glucose is still more than 11.1mmol/L (200mg/dl).
Embodiment 5
One women, 58 years old,
Historical 15 years of diabetes, fasting glucose is between 8.6-13mmol/L (155-234mg/dl), and post-prandial glycemia is up to 23mmol/L (414mg/dl).By 7 days treatment, every day breakfast, lunch and dinner, at first mouthful in 5-10 minute after meal, orally give Fructus Citri Limoniae oil 1ml, blood glucose peak-peak 18.7mmol/L (337mg/dl) is at 1.25h after breakfast.Contrast before and after the treatment, blood glucose on average reduces the medium diet that 6.99mmol/L (126mg/dl) patient keeps appropriateness during this period.
Embodiment 6
Healthy volunteer's experiment
One male, 24 years old, healthy no any disease.Fasting glucose is in 4.4-5.3mmol/L (79-96mg/dl) fluctuation, and post-prandial glycemia is between 6-7mmol/L (108-126mg/dl).By 7 days treatment, every day breakfast, lunch and dinner, at first mouthful in 5-10 minute after meal, orally give Oleum Citri Reticulatae 1.2ml, blood glucose peak-peak 5.6-8.0mmol/L (101-144mg/dl) is at 0.5h after breakfast.Contrast before and after the treatment, the basic no change of blood glucose.The experimenter keeps the medium diet of appropriateness during this period.
Embodiment 7
Healthy volunteer's experiment
One women, 46 years old, healthy no any disease.Fasting glucose is in 5.0-5.4mmol/L (79-96mg/dl) fluctuation, and post-prandial glycemia is between 8-12.2mmol/L (144-202mg/dl).The carbohydrate tolerance experiment is unusual.By 7 days treatment, every day breakfast, lunch and dinner, at first mouthful in 5-10 minute after meal, orally give Fructus Citri Limoniae oil 1ml, blood glucose peak-peak 10.3-11.7mmol/L (185-211mg/dl) is at 0.5h after breakfast.Contrast before and after the treatment, the basic no change of blood glucose.The experimenter keeps the medium diet of appropriateness during this period.(annotate: the contained d-limonene of Chinese Pharmacopoeia content is 90%, therefore, can be considered as the d-limonene to Fructus Citri Limoniae oil (d-limonene content is 90%))
Industrial applicability
The raw material of monoterpenes compound citrene is mainly from fresh ripening fruits and the pericarp (Pericarp) of rutaceae lemon Citrus limon (L.) Burm.f. and variety thereof, the perhaps fresh maturate peel of rutaceae tangerine Citrus reticulata Blanco and variety thereof or dry mature skin (Chinese medicine dried orange peel pericarpium Citri Reticulatae), or the pericarp of dry young fruit or immature fruit (Chinese medicine rascal pericarpium Citri Reticulatae Viride), or the fresh ripening fruits of sweet orange C.aurantium, pericarp and seed (seed), the perhaps fresh maturate peel of bitter orange Citrus aurantium, the perhaps pericarp of the dry young fruit of bitter orange Citrus aurantium and variety thereof or sweet orange C.aurantium (traditional Chinese medicine citrus aurantium Fructus Aurantii Immaturus), perhaps fresh ripening fruits and the pericarp of Mauritius papeda C.hystrix, perhaps fresh ripening fruits and the pericarp of oily orange C.bergamia, perhaps fresh maturate peel or the dry pericarp of rutaceae Buddha's hand Citrus medica L.Var Sarcodactylis Swingle. Raw material sources are abundant and extensive, and output is very high. Secondly, also can be from other up to about the volatile oil of 80 Plants medicines, extract (oil content is between 0.1-6%).
The place of production comprises Europe, Asia, Africa, Australia, North America and South America. What wherein output was the highest is the Florida State of Brazil and the U.S. of South America, secondly is Australia and South Africa. The places of origin of raw materials is all over the world, and is cheap.
Secondly, the processing method of citrene is simple, and the simplest processing method is to obtain (R)-4-isopropenyl-1-methyl-1-cyclohexene content up to tangerine oil and lemon oil more than the 80-90% by the mode of squeezing.
Above-mentioned essential oil can carry out oil mixing with water by high-shear emulsion machine easily, makes injection; Perhaps add in the powder-beta-dextrin with spray pattern and make tablet, also can directly make the finish soft capsule. Therefore, be suitable for suitability for industrialized production.
Claims (23)
1. the extractive of volatile oil of fresh mature fruit, peel and the leaf of rue family citrus plant Citrus is preparing the purposes of preventing and treating the medicine of diabetes.
2. the extractive of volatile oil of fresh mature fruit, peel and the leaf of rutaceae Fructus Citri Limoniae Citrus limon (L.) Burm.f. and variety thereof is preparing the purposes of preventing and treating the medicine of diabetes.
3. the extractive of volatile oil of the fresh mature peel of rutaceae Fructus Citri tangerinae Citrus reticulata Blanco and variety thereof is preparing the purposes of preventing and treating the medicine of diabetes.
4. the fresh young fruit of rutaceae Fructus Citri tangerinae Citrus reticulata Blanco and variety thereof or immaturity peel are preparing the purposes of preventing and treating the medicine of diabetes.
5. the extractive of volatile oil of fresh mature fruit, peel and the seed of Fructus Citri sinensis C.aurantium is preparing the purposes of preventing and treating the medicine of diabetes.
6. the extractive of volatile oil of the fresh mature peel of Citrus aurantium Linn. Citrus aurantium is preparing the purposes of preventing and treating the medicine of diabetes.
7. the extractive of volatile oil of fresh fruit, peel and the seed of rutaceae grapefruit Citrus paradise Macfayden is preparing the purposes of preventing and treating the medicine of diabetes.
8. the fresh mature fruit of Mauritius papeda C.hystrix and the extractive of volatile oil of peel are preparing the purposes of preventing and treating the medicine of diabetes.
9. the fresh mature fruit of oily orange C.bergamia and the extractive of volatile oil of peel are preparing the purposes of preventing and treating the medicine of diabetes.
10. Chinese medicine Pericarpium Citri Reticulatae pericarpium Citri Reticulatae (dry mature skin of rutaceae Fructus Citri tangerinae Citrus reticulata Blanco and variety thereof) and extractive of volatile oil thereof, the purposes aspect the medicine of preparation treatment diabetes.
11. Chinese medicine Fructus Aurantii Immaturus Fructus Aurantii Immaturus (peel of the dry young fruit of Citrus aurantium Linn. Citrus aurantium and variety thereof or Fructus Citri sinensis C.aurantium) and extractive of volatile oil thereof are in the purposes of the medicine for preparing prevention and treatment diabetes.
12. Chinese medicine Fructus Aurantii Fructus Aurantii (the dry immature fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L.) and extractive of volatile oil thereof are in the purposes of the medicine for preparing prevention and treatment diabetes.
13. Chinese medicine Fructus Citri Sarcodactylis Fructus Citri Sarcodactylis (fresh mature peel or the dry peel of rutaceae Fructus Citri Sarcodactylis Citrus medica L.Var SarcodactylisSwingle) and extractive of volatile oil thereof are in the purposes of the medicine for preparing prevention and treatment diabetes.
14. Chinese medicine Rhizoma Et Radix Notopterygii Rhizoma seu Padix Notopterygii (samphire Rhizoma Et Radix Notopterygii Notopterygium incisum Ting exH.T.chang or Radix et Rhizoma Notopterygii N.forbesii Boiss rhizome and root) and extractive of volatile oil thereof are in the purposes of the medicine for preparing prevention and treatment diabetes.
15. Chinese medicine Folium Perillae Folium Perillae (dried leaves of labiate Folium Perillae Perilla frutescens (L.) Britt.) and extractive of volatile oil thereof are in the purposes of the medicine for preparing prevention and treatment diabetes.
16. Chinese medicine Flos Magnoliae Flos Magnoliae (Magnoliacea plant YULAN M denudate Desr.[M.heptapeta (Buch.) Dandy; M.conspicua Salisb; M.yulan Desr.] dry flower) and extractive of volatile oil, in the purposes of the medicine of preparation prevention and treatment diabetes.
17. Chinese medicine Pericarpium Zanthoxyli Pericarpium Zanthoxyli (dry mature skin of rutaceae green pepper Zanthoxylum schinifolium Sieb.Et Zucc. or Pericarpium Zanthoxyli Zanthoxylum bungeanum Maxim or pericarpium Zanthoxyli Z.simulans Hance) and extractive of volatile oil thereof are in the purposes of the medicine for preparing prevention and treatment diabetes.
18. Chinese medicine Folium Artemisiae Argyi Folium Artemisiae Argyi (dried leaves of feverfew Chinese mugwort Artemisia argyi Le vl.et Vant.) and extractive of volatile oil thereof are in the purposes of the medicine for preparing prevention and treatment diabetes.
19. Chinese medicine Fructus Foeniculi Fructus Foeniculi (dry mature fruit of samphire Fructus Foeniculi Foeniculum vulgare Mill.) and extractive of volatile oil thereof are in the purposes of the medicine for preparing prevention and treatment diabetes.
20. Chinese medicine Fructus Litseae Fructus Litseae (dry mature fruit of canella cubeb litsen tree Litsea cubeba (Lour.) Pers.) and extractive of volatile oil thereof are in the purposes of the medicine for preparing prevention and treatment diabetes.
21. the extractive of volatile oil of the flower of ericad Hemerocallis citrina Baroni Cuculus polioephalus Rhododendron anthopogonoides Maxim. is in the purposes of the medicine for preparing prevention and treatment diabetes.
22. the extractive of volatile oil of the seed of samphire Fructus anethi Anethum graveolens L. is in the purposes of the medicine for preparing prevention and treatment diabetes.
23. Chinese medicine Herba Schizonepetae Herba Schizonepetae (dry aerial parts of Herba Schizonepetae Schizonepeta tenuifolia Briq) and extractive of volatile oil thereof are in the purposes of the medicine for preparing prevention and treatment diabetes.
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| CNA2006100459198A CN101028363A (en) | 2006-02-28 | 2006-02-28 | Use of plant or herb and its volatile oil extract in preparation of medicine for treating diabetes |
| PCT/CN2007/000550 WO2007098680A1 (en) | 2006-02-28 | 2007-02-15 | The uses of d-limonene, plant or valatile oil thereof containing d-limonene in manufacturing medicaments for preventing and treating diabetes |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2009053793A2 (en) * | 2007-08-27 | 2009-04-30 | Gang Shu | Use of volatile oil from plants in preparing medicaments for preventing and treating diabetes |
| CN103845634A (en) * | 2012-12-04 | 2014-06-11 | 中国医学科学院药物研究所 | Application of Cymbopogon plant extractive as insulin sensitizing medicine |
| CN103952239A (en) * | 2014-05-08 | 2014-07-30 | 浙江中烟工业有限责任公司 | Method for extracting essential oil from fresh bergamot and application of essential oil in cigarettes |
| CN104719351A (en) * | 2015-02-05 | 2015-06-24 | 成都新朝阳作物科学有限公司 | Schizonepeta extractive and application thereof |
| CN105412317A (en) * | 2015-12-07 | 2016-03-23 | 中国科学院西双版纳热带植物园 | Zanthoxylum myriacanthum Huang essential oil and application thereof in preparing medicine for treating diabetics |
| CN105535195A (en) * | 2016-01-05 | 2016-05-04 | 邱钱勇 | Traditional Chinese medicine preparation for treating diabetes and preparation method and application thereof |
| US10111923B2 (en) | 2015-04-29 | 2018-10-30 | Infinitus (China) Company Ltd | Compositions comprising Cyclocarya paliurus extract and preparation method and uses thereof |
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| CN106283846A (en) * | 2016-10-10 | 2017-01-04 | 四川兴睿龙实业有限公司 | A kind of antibacterial Chinese medicine compound volatile oil and Chinese medicine paper thereof with and preparation method thereof |
| FR3061658A1 (en) * | 2017-01-07 | 2018-07-13 | Guy Faustin Monkam Nitcheu | PHARMACEUTICAL COMPOSITION COMPRISING AS ACTIVE INGREDIENT A COMBINATION OF D-LIMONEME, LUPEOL AND CINNAMALDEHYDE AND / OR POLYMERIC METHYLHYDROXYCHALCONE AND / OR BETA-SITOSTEROL AND / OR |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2111384A (en) * | 1981-08-03 | 1983-07-06 | Wynne David | Improvement in preventative and curative medicine |
| DE19644422C2 (en) * | 1996-10-25 | 2000-06-15 | Stefan Schulz | Use of terpenes to treat autoimmune diseases and graft rejection |
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- 2007-02-15 WO PCT/CN2007/000550 patent/WO2007098680A1/en active Application Filing
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| WO2009053793A2 (en) * | 2007-08-27 | 2009-04-30 | Gang Shu | Use of volatile oil from plants in preparing medicaments for preventing and treating diabetes |
| WO2009053793A3 (en) * | 2007-08-27 | 2009-07-09 | Gang Shu | Use of volatile oil from plants in preparing medicaments for preventing and treating diabetes |
| US8337907B2 (en) | 2007-08-27 | 2012-12-25 | Gang Shu | Use of volatile oil from plants in preparing medicaments for preventing and treating diabetes |
| CN103845634A (en) * | 2012-12-04 | 2014-06-11 | 中国医学科学院药物研究所 | Application of Cymbopogon plant extractive as insulin sensitizing medicine |
| CN103845634B (en) * | 2012-12-04 | 2019-12-13 | 中国医学科学院药物研究所 | application of citronella plant extract as insulin sensitizing drug |
| CN103952239A (en) * | 2014-05-08 | 2014-07-30 | 浙江中烟工业有限责任公司 | Method for extracting essential oil from fresh bergamot and application of essential oil in cigarettes |
| CN104719351A (en) * | 2015-02-05 | 2015-06-24 | 成都新朝阳作物科学有限公司 | Schizonepeta extractive and application thereof |
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| CN105412317A (en) * | 2015-12-07 | 2016-03-23 | 中国科学院西双版纳热带植物园 | Zanthoxylum myriacanthum Huang essential oil and application thereof in preparing medicine for treating diabetics |
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