GB2111384A - Improvement in preventative and curative medicine - Google Patents
Improvement in preventative and curative medicine Download PDFInfo
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- GB2111384A GB2111384A GB08123639A GB8123639A GB2111384A GB 2111384 A GB2111384 A GB 2111384A GB 08123639 A GB08123639 A GB 08123639A GB 8123639 A GB8123639 A GB 8123639A GB 2111384 A GB2111384 A GB 2111384A
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- citrus
- acid
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- lemon
- compound
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
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- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
This invention deals with a homoepathic type compound. The compound consists in whole or in part (dependant on the batch) of- Limonene, Limonin, Rutin, and Pinene, all of which are natural, i.e. bio- organic substances found in different higher plants of the botanical families (i) Rutaceae, Myrtaceae and Coniferae, also in Polygonaceae, Solanceae, Oleaceae, Saxifragaceae, eg. All contain volatile oils (volatile essences), it also consists of ascorbic acid (vitamin C), linoleic acid, linolenic acid (vitamin F), isopropyl alcohol bioflavonoids (vitamin P group, citrin). The compound was found to have useful (ii) pharmacological properties in the treatment of Post irradiation disease, complications following chemotherapy, Biliary/liver damage, Lipoproteinaemias, Arteriosclerosis, Decompensated Diabetes with Ketoacidosis. Acts as cofactor in Intermediary Metabolism of nutrients (and Acetylcoenzye A), Lowers Pyruvate-Lactate in Blood, and generally aids the healing process (iii) of the body by restoring the pH of body fluid and correcting impaired metabolic function. i
Description
SPECIFICATION
Improvement in preventative and curative medicine
This invention deals with a homoeopathic compound hereinafter to be known as
Metamorf (Compound 561). The compound in this invention consists in whole or in part (dependent on the batch) of-Limonene, Limonin,
Rutin and Pinene, all of which are natural, i.e. bioorganic substances found in different higher plants of the botanical families Rutaceae,
Myrtaceae and Coniferae, also in Polygonaceae,
Solanaceae, Oleaceae, Saxifragaceae, etc. All of these contain volatile oils (volatile essences) in their ieaves, blossoms, fruits, peels, needles and barks; it also consists of ascorbic acid (vitamin C), linoleic acid, linolenic acid (vitamin F), isopropyl alcohol, bioflavonoids (vitamin P group, citrin).
Botany
The main species of the family Rutaceae are the genus Citrus with the following species: Citrus auratium amara L. (orange), Citrus auran tifolia vijapura Christm., Citrus acida Christm. (lime),
Citrus medica L; (acid lime), Citrus bergamia L.
(Risso, lemon) C. grandis L. (grape fruit), C.
decumana (Osbeck grapefruit), C. Lemon L.
(lemon) C. medica var. limonum L. (lemon limonero); C. limonia L. (lemon); C. medica matulunga L. (citron), C. nobilis Lour, C. reticulata
Blando (mandarin orange), C. sinesis L. (orange),
Feronia limonia L. Phyllodendron amurense Rupr.,
Ruta agrestis graveolens L. Ruta montana Mill.,
Zanthoxylum americanum Mill., hermaphroditum schinifolium, Aegle marmelos L., Casimiroa edulis
L., C. sapota, and others belonging to the families
Myrtaceae L. and Coniferae L.
Bio-organic chemistry
The volatile essences or volatile oils of
Limonene, Limonin, Rutin and Pinene consist of mixtures of unsaturated alicyclic (ring) compounds called terpenes (or terpenoids) which have the empirical formula (C5H8)n and oxidation products of these. These terpenes are built up of isoprene (C5H8) units. These terpenes are used in other industries. The monoterpene Limonene
C10H16, is synthetized by the citrus plant as d
Form, I-Form, and dl (racemic inactive) form or dipentene. It is a liquid of a pleasant lemon like odour, and of the structure formula
which reads as 1-methyl-4-(1-methylethelnyl)-cyclohexene.
The Pinene, also a monoterpene C,OH18, is naturally synthetized by the pine tree as d-a- pinene or l-a-pinene. It is a liquid of characteristic pine needle scent of turpentine. Its structure formula is
which reads as 2,6,6-trimethyl-bycyclo 3.1.1hept-2-ene.
The Rutin (or Quercetin), a penta-hydroxyflavone-rutinoside C27H300,6, as hydroscopic anhydride forms needle crystals of pale yellow to brown colour. It is synthetized in the nature of many plants especially in buckwheat (Fagopyrum esculentum Moench, Polygonaceae). Its structure formula is
Limonin or Limonoic acid, a triterpene of the
Euphol type of the empirical formula C26H3008, is the bitter principle of lemons and other Rutaceae.
It consists of two lactone rings, a p-substituted flavouring, a ketonic oxygen atom and two ethereal oxygen rings. Its bitter crystals dissolved in isopropanolol. Its structure formula
which resembles the steroid structure, produced by plants whereas steroid hormones are produced by primates and man.
Pharmacology
The terpenes Limonene and Limonic are important ingredients in the food industry. A compound (Metamorf-compound 561) based on a mixture of these two substances has been found to have useful pharmacological properties.
The British Pharmacopoea 1 968 accepts lemon peel as an expectorant, diuretic, antihistamine and anti-inflammatory agent. The Liquor ammoniae citricus is one of the oldest remedies used in cough mixtures.
The Metamorph Compound 561 acts as a buffer within the alkaline reserve of blood. It helps to stabilise the optimal pH of the blood by maintaining the acid/bas balance of the physiologic Buffer systems of blood. It shifts the metabolic or respiratory acidosis by assisting to decompose the lactic acid; or, the metabolic or respiratory alkalosis by stabilising the Na:K ratio in blood and in the cells in vivo.
It maintains the cell membrane by assisting the
Na-pump and calcium ions, which penetrate the cell membrane, act as emulsifiers and maintain the surface activity. It acts as an inorganic trace element carrier for the intracellular enzymes containing Zn or Cu ions, and act so as enzyme activators by carrying the co-enzyme, i.e. the trace metal as catalyst. It influences the maintenance of the Zn:Cu:Cd, of the Ca:Mg, and
Na:K by preserving their optimal biological ratio.
Terpenes are manufactured by the human liver where they are needed for the production of mevalonic acid. This acid is an intermediate affecting the intermediary metabolism of acetate and acetyl-CoA degradation. Limonene obviously mediates the condensation of the liver's own monoterpene derivative geranyl-pyrophosphate and acts as an intermediator of its "head to tail" addition.
The optimal pH of blood in chronic respiratory and metabolic acidosis and alkalosis is particularly important for the maintenance of the homeostasis of the fluidity: coagulability of the circulating blood, the interstitial tissue fluids, and of the total internal environment as defined by
Bernard and Cannon. This is of particular importance in the various chronic diseases and diseases of metabolic origin.
In homoepathic doses it acts as a stimulator of gastric and duodenal secretion of mucin and affects beneficially ulcerations of these segments of the gastro intestinal tract, and aspirin induced stomach bleeding. It increases pancreatic enzyme secretion, and secretion of Pancreozymin, all of which have anti-inflammatory characteristics. It also acts as anitihistamine, antiserotonin, and anti-bradykin and so affects its analgesic action.
The auto-immunization process of the central nervous system results in demyelination when the lymphocytes fail to recognise the body's own proteins, and giest myelin, the compound initiates here an inflammatory response. The compound mediates the reversibility of the early demyelination and improves or slows down the process in later stages of the multiple sclerosis patient.
Treatment also aids in the restoration of a proper cell function, following cell damage by improving the metabolic function. In this way the sick cell can be converted into a normal one.
Summary
Metamorf (Compound 561) was found to be acting as:
(i) A buffer and stabilizer within the alkaline reserve of blood.
(ii) Influences the majority of enzymatic processes at the cellular and subcellular level, dependent on an optimal pH.
(iii) It has a saponin-like action in the sense of an emulsifier acting on the cell membrane, one of which is the maintenance of the fluidity: coagulability of blood.
(iv) It is a detoxificating agent mediating a correct performance of the intermediary metabolism of the liver, particulary that of the mevalonic acid.
(v) It mediates the secretion of mucin by its local action on the mucosa of the upper part of the gastro-intestinal tract.
(vi) Bradykinin triggers off the pain. The compound neutralizes this and/or influences its intensity, and shows it analgesic properties.
(vii) Mediates the reversibility of the early demyelination and improves or slows down the process in later stages of the multiple sclerosis.
Claims (Filed on 24 Aug 1982)
1. A homeopathic type compound comprising entirely of terpenes in emulsions. All natural extracts of higher plants of the botanic families.
Ruteceae. Myrtaceae. Coniferae. Polygonaceae.
Solanaceae Oleaceae. Saxifragaceae..etc. with no chemical additives. or All natural higher plant extracts Limonene. Limonin. Pinene. Ascorbic
Acid. Natural Pure Cider Vinegar. Carotene. Ethel
Alcohol. Linolleic Acid. Linolenic Acid. Vehicle.
Emulsifier. Citrus Acida Christmas (lime). Citrus
Bergamia L. (Risso Lemon) Citrus Lemon L.
(Lemon), or all natural higher plants extracts
Limonene. Limonin. Pinene. Ascorbic Acid.
Carotene. Ethel Alcohol. Linoleic Acid. Linolenic
Acid. Vehicle. Emulsifier. Citrus Acida'Christmas (Lime). Citrus Begamia L. (Risso Lemon). Citrus
Lemon L. (Lemon). Citrus Medica Matulunga L.
(Citron). Citrus Reticulata Blando. Ruta Agrestis
Graveolens L., Ruta Montana Mill., and all other
Higher Plants dependent on the batch. These terpenes are built up of Isoprene (CsH8) units.
2. A homeopathice type compound as claimed in claim 1. The main species of the family Rutaceae are the genus Citrus with the following species:
Citrus auratium amara L. (Orange) Citrus auran tifolia vijapura Christm. Citrus acida Christm.
(Lime). Citrus medica L. (Acid Lime). Citrus bergamia L. (Risso, lemon). Grandis L.
(Grapefruit). C. decumana (Osbeck grapefruit), C.
Lemon L. (lemon) C. medica var. limonum L.
(lemon limonero) C. limonia L. (lemon); C. medica
**WARNING** end of DESC field may overlap start of CLMS **.
Claims (6)
1. A homeopathic type compound comprising entirely of terpenes in emulsions. All natural extracts of higher plants of the botanic families.
Ruteceae. Myrtaceae. Coniferae. Polygonaceae.
Solanaceae Oleaceae. Saxifragaceae..etc. with no chemical additives. or All natural higher plant extracts Limonene. Limonin. Pinene. Ascorbic
Acid. Natural Pure Cider Vinegar. Carotene. Ethel
Alcohol. Linolleic Acid. Linolenic Acid. Vehicle.
Emulsifier. Citrus Acida Christmas (lime). Citrus
Bergamia L. (Risso Lemon) Citrus Lemon L.
(Lemon), or all natural higher plants extracts
Limonene. Limonin. Pinene. Ascorbic Acid.
Carotene. Ethel Alcohol. Linoleic Acid. Linolenic
Acid. Vehicle. Emulsifier. Citrus Acida'Christmas (Lime). Citrus Begamia L. (Risso Lemon). Citrus
Lemon L. (Lemon). Citrus Medica Matulunga L.
(Citron). Citrus Reticulata Blando. Ruta Agrestis
Graveolens L., Ruta Montana Mill., and all other
Higher Plants dependent on the batch. These terpenes are built up of Isoprene (CsH8) units.
2. A homeopathice type compound as claimed in claim 1. The main species of the family Rutaceae are the genus Citrus with the following species:
Citrus auratium amara L. (Orange) Citrus auran tifolia vijapura Christm. Citrus acida Christm.
(Lime). Citrus medica L. (Acid Lime). Citrus bergamia L. (Risso, lemon). Grandis L.
(Grapefruit). C. decumana (Osbeck grapefruit), C.
Lemon L. (lemon) C. medica var. limonum L.
(lemon limonero) C. limonia L. (lemon); C. medica
matulunga L. (citron), C. nobilis Lour; C. reticulata
Blando (mandarin orange). C. sinesis L. (orange);
Feronia limonia L. Phyllodendron amurense
Rupre., Ruta agrestis gravelens L. Ruta montana
Mill., Zanthoxylum americanum Mill., hermaphoditum schinifolium, Aegle marmelos L.,
Casimiroa edulis L., sapota, and others belonging to the families Myrtaceae L. and Coniferae L.
3. As claimed in any preceding claim. The volatile essences or volatile oils of Limonene,
Limonin, Rutin and Pinene consist of mixtures of unsaturated alicyclic (ring) compounds called terpenes (or terpenoids) which have the empirical formula (C5H8)n and oxidation products of these.
These terpenes are built up of isoprene (C5H8) units. These terpenes are used in other industries.
The monoterpene Limonene (C,OH,6) is synthetized by the citrus plant as d-Form, I-Form, and dl (racemic inactive) form or dipentene. It is a liquid of a pleasant lemon like odour, and of the structure formula which reads as 1-methyl-4- (methyl-ethelnyl)-cyclohexene. The Pinene, also a monoterpene C,OH,6 is naturally synthetized by the pine tree as d-a-pinene or l-a-pinene. It is a liquid of characteristic pine needle scent of terpentine. and of a structure formula which reads as 2,6,6,-trimethylbycyclo 3.1.1 .-hept-2-ene. The
Rutin (or Quercetin), a penta-hydroxy-flavonerutinoside C27 H30 O,, as hygroscopic anhydride forms needle crystals of pale yellow to brown colour.It is syntheetized in the nature of many plants especially in buckwheat (Fagopyrum esculentum Moench, Polygonaceae. Limonin or limonic acid a triterpene of the Euphol type of the empirical formula C26 H30 8 is the bitter principle of lemons and other Rutaceae. It consists of two lactone rings, a jB-sunstituted flavouring, a ketonic oxygen atom and two ethereal oxygen rings. Its bitter crystals dissolved in isopropanolol., and of a structured formula which reads, resembles the steroid structure, produced by plants whereas steroid hormones are produced by primates and man.
4. As claimed in any preceding claim. The terpenes Limonene and Limonin are important ingredients. A compound (Metamorf compound 561. "2" (561) "3" (561) based on a mixture of these two substances has been found to have useful pharmacological properties. The British
Pharmacopoea 1 968 accepts lemon peel as an expectorant, diuretic, anti-histamine, and anti inflammatory agent. The Liquor ammoniae citricus is one of the oldest remedies used in cough mixtures. Terpenes are manufactured by the human liver where they are needed for the production of mevalonic acid. This acid is an intermediate affecting the intermediary metabolism of acetate and acetyl-CoA degradation. Limonene mediates the condensation of the liver's own monoterpene derivative geranyl-pyrophosphate, and acts as an intermediator of its "head to tail" addition.It helps to stabalise the optimal pH of the blood by maintaining the acid/bas balance of the physiologic Buffer systems of blood. It shifts the metabolic or respiratory acidosis by assisting to decompose the lactic acid; or, the metabolic or respiratory alkalosis by stabilising the Na:K ratio in blood and in the cells in vivo. It maintains the cell membrane by assisting the Na-pump and calcium ions which penetrate the cell membrane, acts as emulsifiers and maintain the surface activity. It acts as an inorganic trace element carrier for the intracellular enzymes containing Zn or Cu ions, and act so as enzyme activators by carrying the co-enzyme, i.e. the trace metal as catalyst. It influences the maintenance of the
Zn:Cu:Cd: of the Ca:Mg, and Na:K by preserving their optimal biological ratio.
5. As claimed in any preceding claim. The optimal pH of blood in chronic respiratory and metabolic acidosis and alkalosis is particularly important for the maintenance of the homeostasis of the fluidity: coagulability of the circulating blood, the interstitial tissue fluids, and of the total internal environment as defined by
Bernard and Cannon. This is of particular importance in the various chronic diseases, and diseases of metabolic origin. In homoepathic type doses, the compounds acts as stimulators of gastric and duodenal secretion of mucin, and affects beneficially ulceration of these segments of the gastro intestinal tract, it does not irritate the mucosa of the gastro intestinal tract, and asprin induced stomach bleeding is also benefically affected. It increases pancreatic enzye secretion of Pancreozymin, all of which have antiinflammatory characteristics.It also acts as antihistamine, antiserotonin, and anti-bradykin and so affects its anagesic action. The autoimmunization process of the central nervous system results in demyelination when the lymphocytes fail to recognise the body's own proteins, and digest myelin, the compounds initiates here an anti inflammatory response. The compounds mediate the reversibility of the early demyelination and improves or slows down the process in later stages of multiple sclerosis patients. Treatment also aids in the restoration of a proper cell function, following cell damage by improving the metabolic function. In this way the sick cell can be converted into a normal one. The penetration of the oxygen into the damaged tissue is made possible. The effectiveness of the volatile essences. It aids the regeneration of the affected cartilage tissue by contributing to the synthsis of the glycoaminoglycans, and so
improving the permeability of the cartilage, nutrion of collagen and its water content. It also aids the secretion of pancreozymine that acts as local anti-inflammatory agent.
6. As claimed in any previous claim. The
Metamorf compounds 561, "2" (561) "3" (561) was found to be acting as:- A buffer and stabiliser within the alkaline reserve of blood.
Influences the majority of enzymatic processes at the cellular and subcellular level, (enzyme activator) dependent on an optimal pH. It has a saponim-like action in the sense of an emulsifier acting on the cell membrane, one of which is the maintenance of the fluidity: coagulability of blood.
It is a detoxificating agent meadiating a correct performance of the intermediary metabolism of the liver, particularly that of the mevalonic acid.
Influences the degradation of pyrovate into acetyl-co enzyme-A and the initiation of the citricacid-cycle (Kreks cycle). It mediates the secretion of mucin by its local action on the mucosa of the upper part of the gastro-intestinal tract.
Bradykinin triggers off the pain. The compound neutralizes this and/or influences its intensity, and shows it analgestic properties. Mediates the reversibility of the early demyelination and improves or slows down the process in later stages of the multiple sclerosis. The formulation is such that it is impossible to overdose, and there are no known side effects. Taken orally undiluted before meals. No liquids for 30 minutes after taken.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08123639A GB2111384A (en) | 1981-08-03 | 1981-08-03 | Improvement in preventative and curative medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08123639A GB2111384A (en) | 1981-08-03 | 1981-08-03 | Improvement in preventative and curative medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB2111384A true GB2111384A (en) | 1983-07-06 |
Family
ID=10523647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB08123639A Withdrawn GB2111384A (en) | 1981-08-03 | 1981-08-03 | Improvement in preventative and curative medicine |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2111384A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2222769A (en) * | 1988-09-16 | 1990-03-21 | Toyotama Perfumery | Antitumour agent |
| EP0727987A1 (en) * | 1992-01-31 | 1996-08-28 | The Scripps Research Institute | Inhibition of respiratory burst using posttranslational modification inhibitors |
| EP1213027A3 (en) * | 2000-12-11 | 2003-01-15 | Kyowa Hakko Kogyo Co., Ltd. | Liver function protecting or improving agent |
| WO2007098680A1 (en) * | 2006-02-28 | 2007-09-07 | Gang Shu | The uses of d-limonene, plant or valatile oil thereof containing d-limonene in manufacturing medicaments for preventing and treating diabetes |
| WO2009053793A2 (en) * | 2007-08-27 | 2009-04-30 | Gang Shu | Use of volatile oil from plants in preparing medicaments for preventing and treating diabetes |
-
1981
- 1981-08-03 GB GB08123639A patent/GB2111384A/en not_active Withdrawn
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2222769A (en) * | 1988-09-16 | 1990-03-21 | Toyotama Perfumery | Antitumour agent |
| DE3922666A1 (en) * | 1988-09-16 | 1990-03-22 | Toyotama Perfumery Co | ANTITUMOR MEDIUM |
| FR2636533A1 (en) * | 1988-09-16 | 1990-03-23 | Toyotama Perfumery | PHARMACEUTICAL COMPOSITION AND ANTITUMOR AGENT BASED ON LIMONOIDES CITRUS |
| GB2222769B (en) * | 1988-09-16 | 1992-01-22 | Toyotama Perfumery | Antitumor agent |
| EP0727987A1 (en) * | 1992-01-31 | 1996-08-28 | The Scripps Research Institute | Inhibition of respiratory burst using posttranslational modification inhibitors |
| EP0727987A4 (en) * | 1992-01-31 | 1998-03-11 | Scripps Research Inst | Inhibition of respiratory burst using posttranslational modification inhibitors |
| EP1213027A3 (en) * | 2000-12-11 | 2003-01-15 | Kyowa Hakko Kogyo Co., Ltd. | Liver function protecting or improving agent |
| WO2007098680A1 (en) * | 2006-02-28 | 2007-09-07 | Gang Shu | The uses of d-limonene, plant or valatile oil thereof containing d-limonene in manufacturing medicaments for preventing and treating diabetes |
| WO2009053793A2 (en) * | 2007-08-27 | 2009-04-30 | Gang Shu | Use of volatile oil from plants in preparing medicaments for preventing and treating diabetes |
| WO2009053793A3 (en) * | 2007-08-27 | 2009-07-09 | Gang Shu | Use of volatile oil from plants in preparing medicaments for preventing and treating diabetes |
| US8337907B2 (en) | 2007-08-27 | 2012-12-25 | Gang Shu | Use of volatile oil from plants in preparing medicaments for preventing and treating diabetes |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WAP | Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1) |