CN101023967A - Compound extract of common phellinus fungus and chaga, its preparing method and preparation - Google Patents
Compound extract of common phellinus fungus and chaga, its preparing method and preparation Download PDFInfo
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- CN101023967A CN101023967A CN 200710048738 CN200710048738A CN101023967A CN 101023967 A CN101023967 A CN 101023967A CN 200710048738 CN200710048738 CN 200710048738 CN 200710048738 A CN200710048738 A CN 200710048738A CN 101023967 A CN101023967 A CN 101023967A
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Abstract
The present invention relates to a compound extract of fomes yucafensis and betulin, its preparation method and preparation. Said preparation method includes the following steps: (1), respectively pulverizing fomes yucafensis and betulin; (2), mixing (by weight portion) 2-8 portions of fomes yucafensis powder and 3.5-11.5 portions of betulin powder; soaking the obtained mixturein water, heating to make water extraction, taking out supernatant fluid to obtain the supernatant fluid A; (3), adding water into the mixture extracted by step 2 and making water extraction, taking out supernatant fluid to obtain supernatant fluid B; (4), mixing the above-mentioned two supernatant fluids to obtain their mixed liquor, removing protein, lipid and impurity; and (5), concentrating and drying said mixed liquor so as to obtain the invented compound extract of fomes yucafensis and belutin.
Description
(1) technical field:
The present invention relates to the composite extract of the extract of natural fungus, particularly common phellinus fungus and chaga; The invention still further relates to the preparation method and the preparation thereof of this composite extract.
(2) background technology:
In recent years, because natural fungus has multiple efficacies such as unique blood sugar lowering, cancer-resisting, wound body neither has no side effect again and is generally had an optimistic view of.It is found that Phellinus igniarius (L. ex Fr.) Quel. has antiinflammatory, antioxidation, anticancer generation, propagation and transfer, enhancing immunity, protects the liver dirty, blood sugar lowering, prevents and treats the unique effects of diabetes; And Phaeoporus obliquus can blood sugar lowering and cancer-resisting, have enhancing immunity, antioxidation, antiviral, inhibition O-157 type escherichia coli and other pathogenic bacterium again, can also prevent and improve multiple effects such as hypertension, anaphylactic disease, chronic hepatitis, chronic nephritis, chronic gastritis, gastric and duodenal ulcers and tranquillizing and allaying excitement, analgesia, anti-hypoxia, prevention of osteoporosis disease, blood fat reducing, fat-reducing, drug rehabilitation, skin maintenance.At present, the emphasis of research and development Phellinus igniarius (L. ex Fr.) Quel., Phaeoporus obliquus is to extract its active ingredient and application thereof, and domestic have nearly 10 enterprises to adopt the methods traditional or modern times to extract phellinus linteus extract, Phaeoporus obliquus extract, and launch is arranged.For example application number is: 200510044354.7, and name is called the Chinese invention patent of " a kind of preparation method of Phellinus igniarius (L. ex Fr.) Quel. health care oral liquid ", and this preparation method is: with the Phellinus igniarius (L. ex Fr.) Quel. bacterium is starting strain, carries out liquid fermentation, obtains a large amount of Phellinus igniarius (L. ex Fr.) Quel. karusens; Then the mycelia in the karusen is obtained to be rich in the extracting solution of phellin polysaccharides with the hot water extraction, and make concentrated solution with fermentation liquid; At last this concentrated solution is deployed into the good oral liquid of palatability, this oral liquid has enhance immunity effect preferably.And for example application number is: 03121515.7, name is called the Chinese invention patent of " Phaeoporus obliquus preparation method of extract, purposes and compositions thereof ", the present invention relates to Phaeoporus obliquus preparation method of extract, new medical usage and contain the compositions of Phaeoporus obliquus extract, water of the present invention soaks preparation Phaeoporus obliquus extract repeatedly, and finds extract obtained can be used for preparing stable nerve, anxiety and antidepressant drug.But the report and products thereof of not finding at present the composite extract of common phellinus fungus and chaga as yet appears on the market.
(3) summary of the invention:
The present invention will openly have the composite extract of the common phellinus fungus and chaga of plurality kinds of health care therapeutical effect such as blood sugar lowering, anti-cancer, antioxidation, enhancing immunity; The present invention also will disclose the preparation method and the preparation thereof of this composite extract.
The preparation method of the composite extract of common phellinus fungus and chaga of the present invention, its step is as follows:
1) get Phellinus igniarius (L. ex Fr.) Quel., Phaeoporus obliquus is pulverized; Preferably choosing the live Phellinus igniarius (L. ex Fr.) Quel. dry product sporophore that standing tree does and the Phaeoporus obliquus dry product sporophore that parasitizes on the silver birch of Changbai Mountain, northeast of broad leaf trees such as the poplar that parasitizes northeast, birch, willow, oak pulverizes;
2) get 2～8 weight portion Phellinus igniarius (L. ex Fr.) Quel. ground product and mix with 3.5～11.5 weight portion Phaeoporus obliquus ground product, the mixed powder of gained minces and puts into 1～4 times of water to its weight and soak, and adds hot water and carries, and gets the supernatant of gained water extract, supernatant A is standby; Immersion and water are carried being preferably in the vacuum environment and are carried out, and vacuum is advisable at 30～40KPa; Soak time generally more than 4 hours, was advisable with 10～20 hours; Generally speaking, after the immersion, reheat is warming up to 65～94 ℃, and is incubated 0.5～4 hour;
3) through step 2) mixed powder after extracting adds 1～3 times to the water of its weight in mincing, and adds hot water and carries, and gets the supernatant of gained water extract, and is must supernatant B standby; Water is carried being preferably in the vacuum environment and is carried out, and vacuum is advisable at 30～40KPa; Generally speaking, after mixed powder minces and adds water, heat temperature raising to 65～94 ℃, and be incubated 0.5～4 hour;
4) supernatant A, supernatant B merging are obtained mixed liquor, and remove wherein protein, lipid and impurity; For example can adopt the protein precipitation agent to isolate protein, lipid in the mixed liquor, it is 40% trichloroacetic acid or Lead monosubacetate or Cadmium hydrate. etc. that described protein precipitation agent can be mass concentration, and the addition of protein precipitation agent is generally 0.4%～1% of mixed liquor weight; Also can break away from son by ion exchange resin; Perhaps in mixed liquor, adding the isoamyl alcohol that is equivalent to the chloroform of mixed liquor weight 10%～20% and is equivalent to mixed liquor weight 5%～10%, vibrated 10～15 hours, make protein and chloroform---isoamyl alcohol generates gel, separates from mixed liquor;
5) mixed liquor of gained concentrate, drying, obtain the composite extract of common phellinus fungus and chaga.
The extract that obtains with the method for the invention had both contained the Phellinus igniarius (L. ex Fr.) Quel. Main Ingredients and Appearance---multiple active ingredient such as water solublity such as beta glucan and water-insoluble polysaccharose substance; contain polysaccharide material and other multiple active ingredients such as beta glucan of Phaeoporus obliquus again; the applicant is through studying repeatedly, testing; find that this composite extract had both had anticancer, blood sugar lowering and hemostasis, invigorates blood circulation, dissipating fluid-retention, antidiarrheal effect; have good anticancer, blood sugar lowering, immune activation effect again; effectively anticancer propagation, diffusion, transfer can strengthen body immunity.
Because the composite extract of common phellinus fungus and chaga of the present invention has the effect of good health care and treatment various diseases, therefore, the composite extract of common phellinus fungus and chaga can be applied to various medicaments preparation, make capsule in the capsulae vacuus as the composite extract of common phellinus fungus and chaga is inserted; Or, make powder, granule etc. with the composite extract and the adjuvant mix homogeneously of common phellinus fungus and chaga, also can be made into said other dosage form on the various pharmaceuticss.The present invention is that the preparation of active ingredient not only has blood sugar lowering with the composite extract of common phellinus fungus and chaga; anti-cancer; anticancer; antiinflammatory; antioxidation; anticancer generates; propagation and transfer; enhancing immunity; protect the liver dirty unique effects; simultaneously; also has enhancing immunity; prevention and improve hypertension; anaphylactic disease; chronic hepatitis; chronic nephritis; chronic gastritis; gastric and duodenal ulcers and tranquillizing and allaying excitement; analgesia; anti-hypoxia; prevention of osteoporosis disease; blood fat reducing; fat-reducing; drug rehabilitation; the effect of skin maintenance is specially adapted to diabetics; tumor patient and anti-cancer; blood sugar lowering etc.And composite extract of the present invention is to be that feedstock production forms with the natural plants, and its scientific formulation is reasonable, and extraction process is simple, and is without any side effects, is a kind of safe and reliable, the health care medicine of taking for a long time.
(4) specific embodiment:
Embodiment 1:
1) gets Phellinus igniarius (L. ex Fr.) Quel., Phaeoporus obliquus and be crushed to 20 orders respectively;
2) getting 2 kilograms of Phellinus igniarius (L. ex Fr.) Quel. powder mixes with 3.5 kilograms of Phaeoporus obliquus powder, the mixed-powder of gained is put into vacuum extraction jar (vacuum of jar remains on 32KPa), adding 3 times of water loggings to mixed-powder weight in extraction pot steeped 12 hours, heat temperature raising to 94 ℃ then, and kept this temperature 2 hours, mixed-powder is carried out water carry; The water extract of gained is sent into centrifuge, behind high speed centrifugation, and the supernatant of water intaking extract, it is standby to get supernatant A;
3) in the vacuum extraction jar, add water with weight such as mixed-powder again, heat temperature raising to 86 ℃, and kept this temperature 0.5 hour, mixed-powder is carried out water carry; The water extract of gained is sent into centrifuge, behind high speed centrifugation, and the supernatant of water intaking extract, it is standby to get supernatant B;
4) supernatant A, supernatant B merging are obtained mixed liquor, the adding mass concentration is 40% trichloroacetic acid in mixed liquor, and the addition of trichloroacetic acid is 0.4% of a mixed liquor weight, leaves standstill 18 hours, separates out protein, filters mixed liquor then;
5) filtrate of gained places vacuum concentration pot to be concentrated into 1.35, again concentrated solution is carried out spray drying, obtains the composite extract of common phellinus fungus and chaga.
Embodiment 2:
1) gets Phellinus igniarius (L. ex Fr.) Quel., Phaeoporus obliquus and be crushed to 20 orders respectively;
2) getting 8 kilograms of Phellinus igniarius (L. ex Fr.) Quel. powder mixes with 11.5 kilograms of Phaeoporus obliquus powder, the mixed-powder of gained is put into vacuum extraction jar (vacuum of jar remains on 30KPa), adding 4 times of water loggings to mixed-powder weight in extraction pot steeped 10 hours, heat temperature raising to 65 ℃ then, and kept this temperature 4 hours, mixed-powder is carried out water carry; The water extract of gained is sent into centrifuge, behind high speed centrifugation, and the supernatant of water intaking extract, it is standby to get supernatant A;
3) in the vacuum extraction jar, add 3 times again to the water of mixed-powder weight, heat temperature raising to 94 ℃, and kept this temperature 0.5 hour, mixed-powder is carried out water carry; The water extract of gained is sent into centrifuge, behind high speed centrifugation, and the supernatant of water intaking extract, it is standby to get supernatant B;
4) supernatant A, supernatant B merging are obtained mixed liquor, add Lead monosubacetate in mixed liquor, the addition of Lead monosubacetate is 1% of a mixed liquor weight, leaves standstill 18 hours, separates out protein, filters mixed liquor then;
5) filtrate of gained places vacuum concentration pot to be concentrated into 1.35, again concentrated solution is carried out spray drying, obtains the composite extract of common phellinus fungus and chaga.
Embodiment 3:
1) gets Phellinus igniarius (L. ex Fr.) Quel., Phaeoporus obliquus and be crushed to 10 orders respectively;
2) getting 450 gram Phellinus igniarius (L. ex Fr.) Quel. powder mixes with 740 gram Phaeoporus obliquus powder, the mixed-powder of gained is put into vacuum extraction jar (vacuum of jar remains on 30KPa), adding 2 times of water loggings to mixed-powder weight in extraction pot steeped 10 hours, heat temperature raising to 80 ℃ then, and kept this temperature 1 hour, mixed-powder is carried out water carry; The water extract of gained is sent into centrifuge, behind high speed centrifugation, and the supernatant of water intaking extract, it is standby to get supernatant A;
3) in the vacuum extraction jar, add 1.5 times again to the water of mixed-powder weight, heat temperature raising to 87 ℃, and kept this temperature 2.5 hours, mixed-powder is carried out water carry; The water extract of gained is sent into centrifuge, behind high speed centrifugation, and the supernatant of water intaking extract, it is standby to get supernatant B;
4) supernatant A, supernatant B merging are obtained mixed liquor, add Cadmium hydrate. in mixed liquor, the addition of Cadmium hydrate. is 0.5% of a mixed liquor weight, leaves standstill 18 hours, separates out protein, filters mixed liquor then;
5) filtrate of gained places vacuum concentration pot to be concentrated into 1.35, again concentrated solution is carried out spray drying, obtains the composite extract of common phellinus fungus and chaga.
6) with the composite extract sterilization of gained common phellinus fungus and chaga, insert in the capsulae vacuus, obtain the composite extract capsule of common phellinus fungus and chaga.
Embodiment 4:
1) gets Phellinus igniarius (L. ex Fr.) Quel., Phaeoporus obliquus and be crushed to 20 orders respectively;
2) getting 5000 gram Phellinus igniarius (L. ex Fr.) Quel. powder mixes with 7400 gram Phaeoporus obliquus powder, the mixed-powder of gained is put into vacuum extraction jar (vacuum of jar remains on 40KPa), the water logging of weight such as adding and mixed-powder bubble is 20 hours in extraction pot, heat temperature raising to 90 ℃ then, and kept this temperature 0.5 hour, mixed-powder is carried out water carry; The water extract of gained is sent into centrifuge, behind high speed centrifugation, and the supernatant of water intaking extract, it is standby to get supernatant A;
3) in the vacuum extraction jar, add 1.5 times again to the water of mixed-powder weight, heat temperature raising to 65 ℃, and kept this temperature 4 hours, mixed-powder is carried out water carry; The water extract of gained is sent into centrifuge, behind high speed centrifugation, and the supernatant of water intaking extract, it is standby to get supernatant B;
4) supernatant A, supernatant B merging are obtained mixed liquor, in mixed liquor, add chloroform that is equivalent to mixed liquor weight 20% and the isoamyl alcohol that is equivalent to mixed liquor weight 10%, vibrated 15 hours, making protein and chloroform one isoamyl alcohol generate gel separates out, mixed liquor is removed protein and impurity through the centrifuge high speed centrifugation then;
5) mixed liquor of gained places vacuum concentration pot to be concentrated into 1.35, again concentrated solution is carried out spray drying, obtains the composite extract of common phellinus fungus and chaga.
6) getting 1200 gram common phellinus fungus and chaga composite extracts restrains maltodextrins with 8000 gram white sugars, 800 and places mixing and blending machine; stir; make soft material; the soft material that makes is granulated with granulator; with the board-like steam drying case drying of heating, sterilization, granulate, screening, obtain the composite extract granule of common phellinus fungus and chaga.
Embodiment 5:
1) gets Phellinus igniarius (L. ex Fr.) Quel., Phaeoporus obliquus and be crushed to 8 orders respectively;
2) getting 4500 gram Phellinus igniarius (L. ex Fr.) Quel. powder mixes with 7400 gram Phaeoporus obliquus powder, the mixed-powder of gained is put into extraction pot, adds 3 times to the water loggings bubble of mixed-powder weight 11 hours in extraction pot, then heat temperature raising to 82 ℃, and kept this temperature 1 hour, mixed-powder is carried out water carry; The water extract of gained is sent into centrifuge, behind high speed centrifugation, and the supernatant of water intaking extract, it is standby to get supernatant A;
3) in extraction pot, add 1.5 times again to the water of mixed-powder weight, heat temperature raising to 87 ℃, and kept this temperature 2.5 hours, mixed-powder is carried out water carry; The water extract of gained is sent into centrifuge, behind high speed centrifugation, and the supernatant of water intaking extract, it is standby to get supernatant B;
4) supernatant A, supernatant B merging are obtained mixed liquor, in mixed liquor, add chloroform that is equivalent to mixed liquor weight 10% and the isoamyl alcohol that is equivalent to mixed liquor weight 5%, vibrated 10 hours, making protein and chloroform-isoamyl alcohol generate gel separates out, mixed liquor is removed protein and impurity through the centrifuge high speed centrifugation then;
5) mixed liquor of gained places vacuum concentration pot to be concentrated into 1.35, again concentrated solution is carried out spray drying, obtains the composite extract of common phellinus fungus and chaga.
6) getting 940 gram common phellinus fungus and chaga extracts restrains lactose with 30 gram mannitol, 30 and places mixing and blending machine; stir, make soft material, with soft material granulation mechanism grain; with the board-like steam drying case drying of heating, sterilization, granulate, tabletting, obtain the composite extract tablet of common phellinus fungus and chaga.
Experimental example 1:
Experiment crowd: get embodiment 4 described common phellinus fungus and chaga composite extract granules and allow 67 people take respectively; wherein diabetics 21 people, tumor operation, chemotherapy reconvalescent 13 people; hyperpietic 17 people; hyperlipemic patients 9 people; chronic hepatitis patient 7 people; every patient takes granule 1.5 grams of the present invention at every turn, takes every day 3 times.
Experimentation and result: wherein; 21 diabeticss have 14 people to begin onset taking above-mentioned common phellinus fungus and chaga composite extract granule in the time of the 7th day, the 28th day; 19 people's blood glucose, the 1～1.2mmol/L that descends is arranged, account for 72.46% near the euglycemia level when taking 2 months.
Wherein, after 13 tumor operations, chemotherapy reconvalescents took above-mentioned common phellinus fungus and chaga composite extract granule, patient's pain of 85% obviously alleviated, and spirit takes a turn for the better, and appetite increases, and health is improved; After having 6 people to take 1 year, do not see cancer cell metastasis.
Wherein, 17 hyperpietics and 9 hyperlipemic patients were taken above-mentioned common phellinus fungus and chaga composite extract granule after 2 months, had 14 people and 7 people's blood pressures, blood fat can reduce to normal level respectively.
Wherein, 7 chronic hepatitis patients are taken above-mentioned common phellinus fungus and chaga composite extract granule, take 4 people that have of 14 days produce effects, take 1.5 months condition of illness, 6 people that are clearly better, effective percentage 85.71%.
Experimental example 2:
Guilin * * Liao of Food Co., Ltd * * suffer from diabetes 13 years medical histories are arranged, over nearly 4 years, keep blood glucose by insulin injection basically; Get embodiment 4 described common phellinus fungus and chaga composite extract granules every day and take 3 times, take 0.5 gram at every turn, take after 4 months blood glucose and reduce to normal level, backward 8 months insulin injections more not.
Claims (10)
1, the preparation method of the composite extract of common phellinus fungus and chaga, its step is as follows:
1) get Phellinus igniarius (L. ex Fr.) Quel., Phaeoporus obliquus is pulverized;
2) get 2～8 weight portion Phellinus igniarius (L. ex Fr.) Quel. ground product and mix with 3.5～11.5 weight portion Phaeoporus obliquus ground product, the mixed powder of gained minces and puts into 1～4 times of water to its weight and soak, and adds hot water and carries, and gets the supernatant of gained water extract, supernatant A is standby;
3) through step 2) mixed powder that extracts adds 1～3 times to the water of its weight in mincing, and adds hot water and carries, and gets the supernatant of gained water extract, and is must supernatant B standby;
4) supernatant A, supernatant B merging are obtained mixed liquor, and remove wherein protein, lipid and impurity;
5) mixed liquor of gained concentrate, drying, obtain the composite extract of common phellinus fungus and chaga.
2, the preparation method of the composite extract of common phellinus fungus and chaga according to claim 1 is characterized in that: step 2) in, mixed powder minced places that 30～40KPa vacuum environment is soaked, water is carried.
3, the preparation method of the composite extract of common phellinus fungus and chaga according to claim 1 and 2 is characterized in that: in the step 3), mixed powder minced places 30～40KPa vacuum environment water to carry.
4, the preparation method of the composite extract of common phellinus fungus and chaga according to claim 1 and 2 is characterized in that: step 2) in, the soak time that mixed powder minces is 10～20 hours.
5, the preparation method of the composite extract of common phellinus fungus and chaga according to claim 1 and 2 is characterized in that: step 2) in, after mixed powder minces and soaks, heat temperature raising to 65～94 ℃, and be incubated 0.5～4 hour.
6, the preparation method of the composite extract of common phellinus fungus and chaga according to claim 1 and 2 is characterized in that: in the step 3), and after mixed powder minces and adds water, heat temperature raising to 65～94 ℃, and be incubated 0.5～4 hour.
7, the preparation method of the composite extract of common phellinus fungus and chaga according to claim 1 and 2, it is characterized in that: in the step 4), the method for removing wherein protein, lipid and impurity is: employing protein precipitation agent is isolated protein, the lipid in the mixed liquor; Or break away from son by ion exchange resin; Or in mixed liquor, add chloroform and isoamyl alcohol, and vibrated 10～15 hours, make protein and chloroform---isoamyl alcohol generates gel and separates with mixed liquor.
8, the preparation method of the composite extract of common phellinus fungus and chaga according to claim 7 is characterized in that: described protein precipitation agent is that mass concentration is 40% trichloroacetic acid or Lead monosubacetate or Cadmium hydrate..
9, the composite extract of the common phellinus fungus and chaga of any one described method preparation in the claim 1～8.
10, the composite extract preparation of common phellinus fungus and chaga is characterized in that it is that following method is prepared from:
1) get Phellinus igniarius (L. ex Fr.) Quel., Phaeoporus obliquus is pulverized respectively;
2) get 2～8 weight portion Phellinus igniarius (L. ex Fr.) Quel. ground product and mix with 3.5～11.5 weight portion Phaeoporus obliquus ground product, the mixed powder of gained minces and puts into 1～4 times of water to its weight and soak, and adds hot water and carries, and gets the supernatant of gained water extract, supernatant A is standby;
3) through step 2) mixed powder that extracts adds 1～3 times to the water of its weight in mincing, and adds hot water and carries, and gets the supernatant of gained water extract, and is must supernatant B standby;
4) supernatant A, supernatant B merging are obtained mixed liquor, and remove wherein protein, lipid and impurity;
5) mixed liquor of gained concentrate, drying, obtain the composite extract of common phellinus fungus and chaga;
6) composite extract of the common phellinus fungus and chaga of gained is inserted and is made capsule in the capsulae vacuus; Or, make powder, granule with the composite extract and the adjuvant mix homogeneously of common phellinus fungus and chaga.
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| CN2007100487385A CN101023967B (en) | 2007-03-21 | 2007-03-21 | Compound extract of common phellinus fungus and chaga, its preparing method and preparation |
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| CN2007100487385A CN101023967B (en) | 2007-03-21 | 2007-03-21 | Compound extract of common phellinus fungus and chaga, its preparing method and preparation |
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| CN101023967B CN101023967B (en) | 2011-04-20 |
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| CN104840382A (en) * | 2014-02-18 | 2015-08-19 | 株式会社韩国化妆品制造 | Cosmetic composition containing chaga fermentation extract fermented in natural cavern condition |
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| KR20060009529A (en) * | 2004-07-26 | 2006-02-01 | 정구일 | Health foods that characterized by a liquid extract from mixture with inonontus obiquus and phellinus linteus |
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| CN106581166A (en) * | 2016-12-14 | 2017-04-26 | 四川岚晟生物科技有限公司 | Anti-fatigue food, health product or pharmaceutical composition |
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