CN101023915B - Pharmaceutical agent containing birch extract as an effective ingredient and its use - Google Patents
Pharmaceutical agent containing birch extract as an effective ingredient and its use Download PDFInfo
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Abstract
The invention provides a new filaggrinogen or fibrous polyprotein generation accelerator, mantellum protein generation accelerator, cholesterol generation accelerator and cell-activating agent from natural product, which use sap of Betula platyphylla Sukatchev var.japonica Hara as effective constituents.
Description
Technical field
The present invention relates to birch (Betula platyphylla Sukatchev var.japonica Hara) resin (the following birch resin that only is called) is the various drug effect agent of effective ingredient, in addition, relates to the purposes as the various drug effect agent of birch resin.Its application for example is the field of skin preparations for extenal use such as the similar pharmaceutical preparation, external used medicine beyond the cosmetics, medicine.
Background technology
Up to now, for skin preparations for extenal use such as emulsion, emulsifiable paste, astringent, beautifying liquid, facial film, lotion, dispersion liquid, ointment, aerosol, varnish, liniments, can be to wherein adding the various drug effect agent that are used to give specific drug effect.
For example, the composition of preserving moisture of, wrinkle coarse as being used to improve etc. proposes (the interim supplementary issue Vol.9 of fragrance journal (1988), 116-117 pages or leaves such as material glycerol and propylene glycol, saccharide, amino acids; The interim supplementary issue Vol.9 of fragrance journal (1988), 127-128 page or leaf; The interim supplementary issue Vol.23 of fragrance journal, No.1 (1995), 71-79 page or leaf).
Carried out containing the skin preparations for extenal use of these compositions of preserving moisture, thereby kept the trial of skin wet, but have been temporary transient moistening effects, can't keep skin moisture-keeping for a long time through effects of these existing compositions of preserving moisture through coating.In order to keep skin moisture-keeping for a long time, know the mechanism of preserving moisture, the drug effect agent that provides this mechanism directly or indirectly to act on is important.
As a key element that is used for keeping for a long time skin moisture-keeping, can enumerate the profilaggrin (profilaggrin) of the nature moisturizing factor in the promotion skin self and/or the generation of fiber polymeric protein (filaggrin).Yet, also do not know the drug effect agent that promotes that this profilaggrin and/or fiber polymeric protein produce.
In addition; Barrier functionality reduces the caused coarse worried drug effect agent of skin that waits in the epiderm skin as improving; Ceramide (the interim supplementary issue Vol.15 of fragrance journal (1996), 117-127 page or leaf) has been proposed; As the drug effect agent that is used to promote to preserve moisture with the secondary retention function; Proposed cholesterol derivative (the interim supplementary issue Vol.17 of fragrance journal (2000), 123-128 page or leaf),, proposed Montmorillonitum (the interim supplementary issue Vol.17 of fragrancejournal (2000), 175-184 page or leaf) as the drug effect agent that is used to protect skin.
Above-mentioned ceramide is known as the composition that constitutes cytolipin, during suppressing the horny layer barrier functionality that dries out from skin, plays important effect.On the other hand, in this horny layer barrier functionality, known Envelope also plays important effect.In ceramide is such mode; In the drug effect agent that is used at present preventing that the horny layer barrier functionality from reducing; Often through replenishing intercellular lipid and form epithelium realizing improving the effect of barrier functionality, still unknown for the drug effect agent of the effect through promoting Envelope to produce to realize to improve barrier functionality at skin surface.
In addition, cholesterol also is a kind of constituent (accounting for the composition of lipid 25% between corneocyte) of lipid between corneocyte, known can preventing from the epidermis transpiring moisture.Therefore, in order to keep the moistening of skin, the generation that improves cholesterol is important (the interim supplementary issue Vol.17 of fragrance journal (2000), 20-26 page or leaf).Yet, for promoting that the drug effect agent that this cholesterol produces still is unknown.
In addition, at present known is that skin renewal speed reduces and pachylosis owing to the age increase causes the metabolic function of cell to reduce, and causes dermal matrixs such as collagen and elastin laminin to reduce or modification, is attended by phenomenons such as wrinkle and skin elasticity reduction.In addition, owing to can't get rid of old refuse smoothly, the reason of pigementation and the skin obfuscation of therefore also being known as.In order to prevent or improve the carrying out of these phenomenons; Attempt to make cytoactiveization; To promoting the drug effect agent of propagation; Be that cell vitalizing agent is explored,, proposed Nemacystus decipiens (Sur.) Kuck genus (モ ズ Network) extract (opening the 2003-267852 communique) and the extract (opening the 2005-041812 communique) that obtains by croceous female plant etc. referring to the spy referring to the spy for example as cell vitalizing agent.
At above-mentioned illustrative cell vitalizing agent is in the mode of that kind, as the adding ingredient of nearest skin preparations for extenal use, from aspects such as safeties, compares the composition that is more prone to from natural materials with chemical substance.For example, also attempting will be as from the Betula platyphylla Suk. extracting solution of natural goods material, the resin composition as skin preparations for extenal use.For example; Carboxymethyl Chitin in the Betula platyphylla Suk. extracting solution, proposed this Betula platyphylla Suk. extracting solution of combination and the skin aging of Malpighia coccigera (acerola) extract prevent with or pachylosis improve the skin preparations for extenal use (opening the 2000-212027 communique) of usefulness and the pachylosis improvement of the moisture-keeping function excellence of having mixed Betula platyphylla Suk. resin apply some make up (opening the 09-291013 communique) referring to the spy referring to the spy.
Yet in Betula platyphylla Suk. extracting solution or birch resin, profilaggrin or fiber polymeric protein produce facilitation, Envelope produces facilitation, cholesterol generation facilitation or cell-activating effect and also not exclusively knows.
Summary of the invention
The present invention makes in view of above-mentioned problem, and is of the present invention
The 1st problem provides a kind of novel drug effect agent that produces from the promotion profilaggrin or the fiber polymeric protein of natural materials;
The 2nd problem provides a kind of novel drug effect agent that produces from the promotion Envelope of natural materials;
The 3rd problem provides a kind of novel drug effect agent that produces from the promotion cholesterol of natural materials; With
The 4th problem provides a kind of novel drug effect agent with cell-activating effect from natural materials.
Be used to solve the method for problem
In view of above-mentioned enforcement, the present inventor is conceived to carry out meticulous research from the composition from plant in the natural goods composition in order to solve above-mentioned problem, and the result finds that birch resin is effective as the drug effect agent with above-mentioned effect.
That is, the present invention relates to birch (Betula platyphylla Sukatchev var.japonica Hara) resin is the profilaggrin (profilaggrin) or fiber polymeric protein [also claiming to gather keratin filaggrin (filaggrin)] the generation promoter of effective ingredient; Envelope (involucrin) (イ Application ボ Le Network リ Application) produces promoter; Cholesterol produces promoter; And cell vitalizing agent.
In addition, the present invention provides birch (Betula platyphylla Sukatchev var.japonica Hara) resin to produce the purposes of promoter as profilaggrin or fiber polymeric protein from other viewpoint; Produce the purposes of promoter as Envelope; Produce the purposes of promoter as cholesterol; With purposes as cell vitalizing agent.
In addition, the present invention provides through the profilaggrin of employing birch (Betula platyphyllaSukatchev var.japonica Hara) resin or the promotion method of fiber polymeric protein generation from other viewpoint; The promotion method that Envelope produces; The promotion method that cholesterol produces; With cell-activating method (still, any does not all comprise human Therapeutic Method).
The invention effect
According to the present invention, can provide from natural goods, good new profilaggrin or the fiber polymeric protein of safety and produce promoter; Envelope produces promoter; Cholesterol produces promoter; And cell vitalizing agent.
In addition, the skin preparations for extenal use that contains profilaggrin of the present invention and/or fiber polymeric protein generation promoter can promote the generation of nature moisturizing factor in the skin self to continue to keep the moistening of skin.
In addition, the skin preparations for extenal use that contains Envelope generation promoter of the present invention can make the barrier functionality of epiderm skin normal, can expect that the moisture of epiderm skin keeps improving effect, preventing the effect of pachylosis etc.
In addition, the skin preparations for extenal use that contains cholesterol generation promoter of the present invention can promote the generation of cholesterol in the skin self, and the result can prevent water evaporates, continues to keep the moistening of skin.
In addition, the external preparation for skin that contains cell vitalizing agent of the present invention has and suppresses or improve excellent cosmetic result such as pachylosis, skin obfuscation.
Description of drawings
Fig. 1 is an epidermis cell keratinization facilitation result of the test; Add the cellular morphology (embodiment 1) of 10% birch resin situation
Fig. 2 is an epidermis cell keratinization facilitation result of the test; Do not add the cellular morphology (comparative example 1) of situation
Fig. 3 epidermis cell keratinization facilitation result of the test; Add the cellular morphology (comparative example 2) of 1.5mM calcium chloride situation
Fig. 4 is an epidermis cell keratinization facilitation result of the test; The viable count of measuring according to MTTassay compares
Fig. 5 is that cell proliferation promotes result of the test
The best mode that is used to carry out an invention
Below, the present invention is carried out detailed explanation.In addition, "～" in this description is to comprise the implication use that the numerical value of putting down in writing before and after it is lower limit and higher limit.
The birch of using among the present invention (Betula platyphylla Sukatchev var.japonica Hara) is called in the plant of betulaceae (カ バ ノ キ) section and is called Betula platyphylla Suk., diplomorpha (ガ Application ピ); Be Honshu, Hokkaido, Thousand Islands archipelago, Sakhalin, Korea, China, the Siberian fallen leaves Gao Mu that is distributed in to the east of the divergent abundant county; The birch resin that uses among the present invention is to bloom and grow 1 middle of the month of first greenery in early spring, overflows resin from what the trunk middle punch obtained.As the composition of this resin, comprise inorganic matter, saccharide, organic acid, aminoacid etc.In addition, in the present invention, its cultural method and the place of production there is not special qualification.
Method for preparing to the birch resin that uses among the present invention does not have special qualification; An example as the method for preparing of using among the present invention; Can enumerate the resin of taking by trunk 95 ℃ of following heat sterilizations 10 minutes, cooling, with filtering material 5 ℃ of held 3 days; Filter dregs and deposition, thereby obtain.In addition, you can use a commercially available product birch sap, as commercially available products include Sen Shizuku [Limited Sapp (さ つ Bru) manufactured] and so on.
Fiber polymeric protein and profilaggrin are described.The fiber polymeric protein is that molecular weight is the intermediate metabolites of the forerunner's albumen-nature moisturizing factor processes such as profilaggrin decomposition composition aminoacid more than 300,000.This profilaggrin is that the granular cell of epidermis is followed moving of corneocyte and accepted the decomposition of protease, finally keeps the moistening nature moisturizing factor of epidermis (department of dermatologry Mook, No.15 (1989), 49-55 page or leaf).Therefore, in order to keep the moistening of skin, fiber polymeric protein and/or profilaggrin are necessary.In the present invention, through using birch resin, can promote the generation of fiber polymeric protein and/or profilaggrin.
Envelope is the disproportionation that is accompanied by epidermal keratinocytes, and crosslinked through changeing sugared transglutaminase, around cell, forms the CE precursor protein of insoluble film Cornified Envelope (CE).The cell membrane of this Envelope combines with a part as the ceramide of iuntercellular lipid, thereby forms cuticular barrier functionality.That is, in the formation of horny layer barrier functionality, not only as the ceramide of iuntercellular lipid, and the existence of memebrane protein-Envelope bonded with it also is important.In the present invention, through using birch resin, can promote the generation of Envelope.
Cholesterol is a kind of constituent (accounting for about 25% composition of lipid between corneocyte) of liposome between corneocyte, demonstrates and prevents the function of moisture from the epidermis evaporation.In addition, known in aged skin, the function that produces cholesterol worsens.For moistening skin, promote that the generation of the cholesterol that the iuntercellular lipid is contained is important.In the present invention, through using birch resin, can promote to be included in the generation of the cholesterol of iuntercellular liposome.
In addition, know that all owing to the age increase causes the metabolic function of cell to reduce be that skin renewal speed reduces and pachylosis, cause dermal matrixs such as collagen and elastin laminin to reduce or modification, be attended by phenomenons such as wrinkle and skin elasticity reduction.In addition, owing to can't get rid of old refuse smoothly, the reason of pigementation and the skin obfuscation of therefore also being known as.In order to prevent or improve the carrying out of these phenomenons, it is important making cytoactiveization.In the present invention, through using birch resin, can make cytoactiveization.
Purposes to profilaggrin of the present invention or fiber polymeric protein generation promoter, Envelope generation promoter, cholesterol generation promoter or cell vitalizing agent has no particular limits; Owing to use birch resin from natural goods as effective ingredient; Therefore safety is good; From this viewpoint, be preferably used as the active ingredient of skin preparations for extenal use.Content to the drug effect agent of the present invention in the skin preparations for extenal use has no particular limits, and the content of the birch resin of this effective ingredient is preferably 0.0001～50 quality % (following only with " % " expression), and more preferably 0.001～30%.If in this scope; This resin can be stably contained, and facilitation that profilaggrin or fiber polymeric protein produce, facilitation that Envelope produces, facilitation that cholesterol produces or cell-activating effect, the persistence of resultant moistening effect and its effect thus can be brought into play.
In addition; When in skin preparations for extenal use, mixing the birch resin that uses as various drug effect agent; Can take normally used various other drug effect agent in the agent by coupling skin; A kind of work that for example is selected from drug effect agent such as antioxidant, anti-inflammatory agent, cell vitalizing agent, ultraviolet screening agent, wetting agent, blood circulation accelerant is used more than two kinds together, can further improve effect of the present invention.
As the concrete material of these drug effect agent, the material that illustrates below the illustration respectively.Wherein, in " derivant ", comprise the ester and the salt that can form.In addition, because a kind of material has multiple drug effect sometimes, therefore in a plurality of drug effect agent, put down in writing same title.(in addition, under the situation of plant, in bracket, put down in writing the Chinese medicine name of another name in the lump.)
As antioxidant, can enumerate vitamin e and derivant thereof, vitamin C and derivant thereof, carotenoid, dibenzylatiooluene, Butylated hydroxyanisole, rutin and derivant thereof, glutathion and derivant thereof, superoxide dismutase, mannitol, Caulis Spatholobi (ケ イ ケ Star ト ウ) extract, Flos Pelargonii Hortori, Fructus Crataegi extract, Radix Paeoniae Alba extract, Semen Ginkgo extrac, コ ガ ネ バ Na (Radix Scutellariae) extract, Flos Rosae Rugosae (マ イ カ イ, Flos Rosae Multiflorae) extract, septfoil (ト Le メ Application チ ラ) extract, Fructus Vitis viniferae extract, real (the ヤ シ ヤ) extract of arrow car, Radix seu Caulis Embeliae Parviflorae extract, Herba Rosmarini Officinalis (マ Application ネ Application ロ ウ) extract, tea extract (oolong tea, black tea, green tea etc.) etc.
As anti-inflammatory agent, can enumerate glycyrrhizic acid and derivant thereof, enoxolone and derivant thereof, sulfur and derivant thereof, Aloe extract, Radix Angelicae Sinensis (ア シ タ バ) extract, Herba Urticae Cannabinae extract, neat high (the カ ワ ラ ヨ モ ギ) extract of bacterium, Rhizoma Curcumae Longae extract, Cortex Phellodendri (オ ウ バ Network) derivant, Radix Hyperici Monogyni (Herba Hyperici Monogyni) extract, chamomile extract, Symphytum officinale (ヒ レ Ha リ ソ ウ) extract, Flos Lonicerae (キ Application ギ Application カ) extract, Herba Oenanthes Javanicae (cresson) extract, Salvia farinacea (セ-ジ) extract, small burnet (ジ ユ) extract, Folium Perillae (シ ソ) extract, Betula platyphylla Suk. extract, Ramulus Sambuci Williamsii extract, Bufo siccus (ホ オ ウ) extract, Fructus Sapindi Mukouossi extract, eucalyptus extracts, biennial wormwood extract, Radix Astragali extract, speckle bamboo extract, zinc oxide etc.
As cell vitalizing agent, can enumerate Vitamin A and derivant thereof, Germinatus Phragmitis extract, the Semen Pisi sativi collection is carried thing, Chinese date (タ イ ソ ウ) extract, Bulbus Allii extract, Radix Ginseng extract, Bu Nanuokui (Block Na ノ キ) extract, Lac regis apis, yeast extract, microbial fermentation metabolite, Ganoderma extract etc.
As ultraviolet screening agent, can enumerate p-methoxycinnamic acid-(2-ethylhexyl) ester, the 4-tert-butyl group-4 '-methoxy dibenzoyl methylmethane, oxybenzone and derivant, titanium oxide, particulate titanium dioxide, zinc oxide and particulate oxide zinc etc.If inorganic powder such as titanium oxide, zinc oxide uses microgranule, then can bring into play better effect.
As a moisturizing agent include glycerol, 1,3 - butanediol, proteins or derivatives thereof, and salts thereof hydrolyzate (collagen, ester, etc.), hyaluronic acid and its salts, amino acids and their derivatives, carbohydrates, D-panthenol and its derivatives, glycolipids, phospholipids ester, ceramide, urea, mucin, almond extract, avocado extract, A Lu Saudi (ア Hikaru Te ア) extract, spring water, aloe vera extract, mallow (ウ su bell ni ア Io イ) extract, Uno Nice (Io Bruno varnish) extract, oat extract, containing Glabridin (bag ra sleeve ri ji nn), Gulabulei (glabren) (bag ra blurring nn), Lee Library Yi Leach (re-ku イ re チ nn), iso- Lee Library Yi Leach (イ ソ re-ku イ re チ nn), and these substances licorice extract, libraries Yin Haris bucket (ku イ nn su Shin - cloth) extract, ku ra ra (Sophora) extract, gardenia extract, grapefruit extract, watercress ( cresson) extract, gentian extract, geranium extract, burdock extract, wheat extract, Asarum (thermal イ Shin) extract, cactus extract, saponin extract, hawthorn extract, to yellow (ji Io ウ) extract, Shimono (Shin holds an boots Kelly) extract, ginger extract, mallow (ウ su bell ni Tatari チ ア Io イ) extract, mulberry (ソ ウ tension ku Hiroshi) extract, thyme (tie gum) extract, cordyceps extract, three Pennisetum extract, Dokudami (cloth ku double mini) extract, peppermint extract, Coix extract, Hammamet off Leith (tension ma メ squirrel) Extract, Rose (van ra) extract, white cypress extract, dandelion (フ Kita nn pts pts) extract, grape extract, Li extract, loofah extract, Nanjing linden extract, hops (ホ boots plastic) extract, pine extract, warm Boti extract, horse chestnut (Aesculus) extract, off Lissa (メ Ritsu thermal) extract, cornflower extract , lily extract, citron extract, lavender extract, apple extract, rice (co メ) and rice bran (co メ rice bran) extract, black tea extract, boxing smartweed (イ sleeve キ Suites ra Bruno Io) extract, heath (Oh イ zip boots) extract, Siberian Ginseng extract, seaweed extract.
In addition; As (the エ モ リ エ Application ト) agent of preserving moisture, can enumerate heartily that crust oil, macadamia are oily, olive oil, almond oil, Semen Armeniacae Amarum (パ-シ Star Network) oil, safflower oil, Oleum helianthi, American Avocado Tree oil, a thick wood that goes out (メ De ウ ホ-system) oil, Camellia oil, A Mengdou (ア モ Application De) oil, Folium Perillae (エ go マ) oil, Oleum sesami, borage (Le リ ジ サ) oil, cocoa butter, RUMUGUO (シ ア) fat etc. through the sealing skin surface.
As blood circulation accelerant, can enumerate citron extract, arnica montana extract, capsicum oleoresin, calamus extract, γ-Hi-Z etc.
Each composition of these antioxidants, anti-inflammatory agent, cell vitalizing agent, ultraviolet screening agent, wetting agent, blood circulation accelerant can use a kind of or combination more than two kinds is used.
In addition; In the skin preparations for extenal use that contains drug effect agent of the present invention; Can also in the scope of not damaging effect of the present invention, suitably add as normally used various compositions in the cosmetics of material beyond the mentioned component, similar medicine, the external used medicine etc.; That is water, alcohol, polyhydric alcohol, oil preparation, surfactant, viscosifier, powder, chelating agen, antibacterial, enzyme, pH adjustment agent,, from the extract of animals and plants, microorganism, spice etc.
Example as the hybrid mode of the skin preparations for extenal use that contains drug effect agent of the present invention; There is not special qualification; Can be the cosmetics that are selected from for example emulsion, emulsifiable paste, astringent, beautifying liquid, facial film, lotion, organize any mode of cosmetics, dispersion liquid, ointment, liquor, aerosol, adhesive preparation etc., also can be external used medicine etc.
Embodiment
Below, make example, Test Example, embodiment the present invention is explained more specifically through enumerating, but the present invention does not receive any qualification of these examples.
Test Example 1: profilaggrin and/or the determination of yield of fiber polymeric protein
As birch sap (product name "forest Shizukuishi" Limited Sapp (さ つ Bru) Co., Ltd.) for comparative control, using known human epidermal cells in differentiation promoting effect with improved solution of calcium (calcium chloride solution; hereinafter, simply referred to as "calcium solution."), in addition, for contrasting of only in culture medium, cultivating, the effect of giving profilaggrin and/or fiber polymeric protein output is studied.After pro-is cultivated normal human subject neonate epidermis cell, for prevent culture fluid to soak into pressure drop low, freeze-dried through dividing by birch resin 30v/v%, 20v/v%, 10v/v%, each equivalent of 1v/v% with respect to culture medium, be concentrated into 1/10 times and add.In addition, in comparative control, add calcium solution, make that contained calcium ion concentration 0.03mM/mL increases in the original culture medium; In total amount, be 1.5mM/mL, after cultivating a week under the culture medium condition separately; Remove culture medium, carry out 1 washing, reclaim epidermis cell with PBS (-).Then; After in the cell that reclaims, adding the 10mM Tris hydrochloride buffer (comprising 8M carbamide, 1v/v%TritonX-100, protease inhibitor cocktail (adjust, make that EDTA, PMSF, NMF ultimate density separately is 1mM)) of pH7.5, handled 10 minutes down at 4 ℃ through ultrasound wave; With cell pulverization; Remove cell residue through centrifugalize, carry out quantification of protein, in the PAAG of 4-12%, add sample; Make the albumen quality of a sample keep certain, carry out SDS-PAGE.After electrophoresis finished, the protein in the NC Nitroncellulose film on the transfer printing gel was drawn through carrying out Wu Yesi light (ウ エ ス タ Application), thereby is detected profilaggrin and/or fiber polymeric protein.1 time antibody uses Ku Luna land (Network ロ-Na Le) antibody (Biomedical Technologies society system) from anti-people's fibrid polymeric protein mouse; 2 times antibody uses anti-ageing Mus peroxidase labelling IgG (A Maxia wood (ア マ シ ヤ system) society's system), thereby detects through chemical combination flash ranging concentration method.Detected curve negotiating densitometry is read, and obtains growing amount through measuring area, shown in the table 1 with the ratio of the growing amount of contrast.
Table 1
| The sample name | Profilaggrin and/or fiber polymeric protein produce ability (is 100 with contrast) |
| Birch resin 30v/v% equivalent is added | 1099 |
| Birch resin 20v/v% equivalent is added | 1216 |
| Birch resin 10v/v% equivalent is added | 565 |
| Birch resin 1v/v% equivalent is added | 216 |
| Calcium | 388 |
Confirm in birch resin and calcium, all to have the effect that promotes that profilaggrin and/or fiber polymeric protein produce by table 1.In the experimental concentration more than the concentration that affirmation birch resin worsens under than 1v/v% concentration slightly, have higher profilaggrin and/or fiber polymeric protein and produce facilitation.Therefore, find that birch resin has high profilaggrin and/or fiber polymeric protein identical with the known calcium that can promote profilaggrin and/or fiber polymeric protein to produce or on it and produces facilitation.
Test Example 2: the Envelope generation is measured
As the comparative control of birch resin, use the known calcium solution (calcium chloride solution that improves the differentiation facilitation that in the human epidermal cell, has; Below only be designated as " calcium solution ".), in addition, for contrasting of only in culture medium, cultivating, the effect of giving Envelope output is studied.After pro-is cultivated normal human subject neonate epidermis cell, for prevent culture fluid to soak into pressure drop low, freeze-dried through dividing by birch resin 3v/v%, 20v/v%, 10v/v%, each equivalent of 1v/v% with respect to culture medium, be concentrated into 1/10 times and add.In addition, in comparative control, add calcium solution, make that contained calcium ion concentration 0.03mM/mL increases in the original culture medium; In total amount, be 1.5mM/mL, after cultivating a week under the culture medium condition separately; Remove culture medium, carry out 1 washing, reclaim epidermis cell with PBS (-).Then; After in the cell that reclaims, adding the 10mM Tris hydrochloride buffer (comprising 8M carbamide, 1v/v%TritonX-100, protease inhibitor cocktail (adjust, make that EDTA, PMSF, NMF ultimate density separately is 1mM)) of pH7.5, handled 10 minutes down at 4 ℃ through ultrasound wave; With cell pulverization; Remove cell residue through centrifugalize, carry out quantification of protein, in the PAAG of 4-12%, add sample; Make the albumen quality of a sample keep certain, carry out SDS-PAGE.After electrophoresis finished, the protein in the NC Nitroncellulose film on the transfer printing gel was drawn through carrying out Wu Yesi light (ウ エ ス タ Application), thereby is detected Envelope.1 time antibody uses Ku Luna land (Network ロ-Na Le) antibody (abcam society system) from anti-human Envelope mouse, and 2 times antibody uses anti-ageing Mus peroxidase labelling IgG (A Maxia wood (ア マ シ ヤ system) society's system), thereby detects through chemical combination flash ranging concentration method.Detected curve negotiating densitometry is read, and obtains growing amount through measuring area, shown in the table 2 with the ratio of the growing amount of contrast.
Table 2
| The sample name | Envelope generation ability is measured (is 100 with contrast) |
| Birch resin 30v/v% equivalent is added | 157 |
| Birch resin 20v/v% equivalent is added | 154 |
| Birch resin 10v/v% equivalent is added | 146 |
| Birch resin 1v/v% equivalent is added | 127 |
| Calcium | 128 |
Confirm in birch resin and calcium, all to have the effect that promotes that Envelope produces by table 2, confirm that birch resin has higher Envelope and produces facilitation with respect to calcium.Therefore, find that birch resin has the more excellent Envelope of calcium that produces than present known promotion Envelope and produces facilitation.
Test Example 3: the mensuration of cholesterol generation rate
As the comparative control of birch resin, use the known calcium solution (calcium chloride solution that improves the differentiation facilitation that in the human epidermal cell, has; Below only be designated as " calcium solution ".), in addition, for contrasting of only in culture medium, cultivating, the effect of giving cholesterol output is studied.After pro-is cultivated normal human subject neonate epidermis cell, for prevent culture medium to soak into pressure drop low, freeze-dried through dividing by birch resin 30v/v%, 20v/v%, 10v/v%, each equivalent of 1v/v% with respect to culture medium, be concentrated into 1/10 times and add.In addition, in comparative control, add calcium solution, make that contained calcium ion concentration 0.03mM/mL increases in the original culture medium; In total amount, be 1.5mM/mL, after cultivating a week under the culture medium condition separately; Remove culture medium, carry out 1 washing, reclaim epidermis cell with PBS (-).In this human epidermal cell, after interpolation water, chloroform and each 2.5mL of methanol mix, separate chloroform layer, drying.The lipid that extracts is passed through HPTLC plate [silica dioxide gel G60 (20 * 10cm) Art.5641; Lu Ku (メ Le Network) the society's system of going out], with mixed solvent (chloroform: methanol: acetic acid=190: 9: 1) launch 2 times.Behind spraying 40% sulphuric acid, heated 15 minutes with 180 degree, thus color development, then with the cholesterol optical density meter colorimetric assay on the TLC.Tester only in culture medium, to cultivate is 1.0, calculates cholesterol and produces the promotion rate, in this result shown in the table 3.
Table 3
| The sample name | Cholesterol produces ability (is 100 with contrast) |
| Birch resin 30v/v% equivalent is added | 125 |
| Birch resin 20v/v% equivalent is added | 123 |
| Birch resin 10v/v% equivalent is added | 117 |
| Birch resin 1v/v% equivalent is added | 108 |
| Calcium | 105 |
Confirm in birch resin and calcium, all to have the effect that promotes that cholesterol produces by table 3, confirm that birch resin all has higher cholesterol generation facilitation in the experimental concentration arbitrarily with respect to calcium.Therefore, find that birch resin has the more excellent cholesterol of calcium that produces than present known promotion cholesterol and produces facilitation.
Test Example 4: to the keratinization facilitation of epidermal keratinocytes
Use epidermal keratinocytes propagation with culture medium (manufacturing of Ku Labao (Network ラ ボ ウ) society); Is 24 pair jugularias on normal human subject newborn skin epidermal keratinocytes (manufacturing of Ku Labao (Network ラ ボ ウ) society) sowing at diameter with 6000/neck; Under the 5%vol carbon dioxide environment, cultivated 24 hours down at 37 ℃.After the cultivation, with add birch resin to ultimate density be 10% example (embodiment 1), as the example (comparative example 1) that not have to add of comparative example with add calcium chloride, example (comparative example 2) cultivation that feasible ultimate density as positive object is 1.5mM 3 days.After the cultivation, the cell of each sample is photographed, study its form.At the photo of taking shown in Fig. 1～3.In addition, after the photography, calculate viable count through MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-four nitrogen bromides) algoscopy.In result shown in Fig. 4.
By the cellular morphology that illustrates respectively in Fig. 1～3; (embodiment 1: Fig. 1) with the example (comparative example 2: Fig. 3) with the comparative example that does not add these compositions (comparative example 1: Fig. 2) compare that adds calcium chloride for the example of interpolation birch resin; Confirm to have the hypertrophyization and double-layerization of cell, affirmation can promote keratinization.Skin renewal speed is fast more, and promptly metabolic function is high more, then can promote the keratinization of cell more, therefore promotes more keratinization then can demonstrate high cell-activating effect more.
Fig. 4 is the chart of each sample viable count of expression.The common cell of breathing can't be breathed owing to keratinization, as long as horn cell is not peeled off, the oxygen expenditure amount of cultured cell will reduce.Therefore, through quantitative oxygen expenditure amount, can calculate viable count.The sample that viable count is few more can promote keratinization more, promptly demonstrates high cell-activating effect.
By the result of Fig. 4, add the sample (embodiment 1 and comparative example 2) of birch resin and known keratinization agent calcium chloride respectively and compare with the sample (comparative example 1) that does not have to add, the living cells number average reduces, and confirms to have the keratinization facilitation of equal extent.
Test Example 5: cell proliferation facilitation
Use the MTT algoscopy to measure fibrocyte (NB1RGB) cell-activating rate from the human newborn.MTT is through getting in the living cells, with the mitochondrion internal memory enzyme (NADH) reaction, thereby produce the reduction cracking, be created on the insoluble first Za (formazan) that the 570nm place has absworption peak.Because the first Za amount of known these generations is relevant with the NADH amount, therefore will jump up and can dissolve through the first that this method generates, then can measure the energy metabolism activity and the cell number of cell indirectly through measuring absorbance.
On 24 neck microplates, add an amount of culture medium, sowing is from human newborn's fibrocyte, under 37 ℃, is to leave standstill for 5% time at gas concentration lwevel.On the other hand, use birch resin to replace normally used Purified Water, process eagle (イ one グ Le) MEM (manufacturing of Ni Sai (ニ Star ス イ) society), process dilution series with common MEM culture medium.Second day, the culture medium of adding dilution made that the content of birch resin is 75% (embodiment 2), 100% (embodiment 3).Will be in common culture medium cultured cells with comparing (comparative example 3).Cultivate after 4 days, the exchange culture medium is added sample once more.Second day, in each neck, respectively add the solution that 100 μ L prepare respectively, make that MTT (manufacturing of SIGMA society) is 5mg/mL.Cultivate after 4 hours, remove culture fluid, the first of using the isopropyl alcohol dissolving to generate is jumped up.Using the microplate reader, is 630nm with the reference, measures absorbance at the 570nm place, calculates the ratio with respect to contrast.In this result shown in Fig. 5.
By the result shown in Fig. 5, in the sample that adds birch resin, confirm that the propagation of pair cell depends on concentration.By the above, in birch resin, confirm to have the cell-activating effect that promotes cell proliferation.
Following illustration contains the skin preparations for extenal use of the variety of way of the various drug effect agent of the present invention.In addition; Embodiment 1-1～1-9 is the example that contains the skin preparations for extenal use of profilaggrin or fiber polymeric protein; Embodiment 2-1～2-9 contains the example that Envelope of the present invention produces the skin preparations for extenal use of promoter; Embodiment 3-1～3-9 contains the example that cholesterol of the present invention produces the skin preparations for extenal use of promoter, and embodiment 4-1～4-9 is the example that contains the skin preparations for extenal use of cell vitalizing agent of the present invention.
(embodiment 1-1: astringent)
(composition) (%)
(1) glycerol 3.0
(2) 1,3 butylene glycol 2.0
(3) propylene glycol 4.0
(4) oleyl alcohol 0.1
(5) mono laurate polyoxyethylene (20E.O.) dehydration sorbose 1.5
Alcohol ester
(6) polyoxyethylene (20E.O.) lauryl ether 0.5
(7) Squalene 0.5
(8) ethanol 15.0
(9) acetic acid dl-alpha-tocopherol * 1 0.5
(10) spice is an amount of
(11) glycyrrhizic acid dicalcium * 2 0.5
(12) Herba Rosmarini Officinalis extract * 3 0.5
(13) dl-2-pyrrolidone-5-carboxylic acid * 4 0.2
(14) tracasol 1.0
(15) Semen Coicis extract * 5 0.5
(16) birch resin * 6 20.0
(17) Purified Water surplus
* 1 carry (エ-ザ イ) society's system especially
* 2 balls are apt to pharmacy society system
* 3 balls are apt to pharmacy society system
* () of 4 flavors plain society makes
* 5 balls are apt to pharmacy society system
* 6 Sapp (さ つ Bru) manufactured (Sen Shizuku)
(method for making)
A. mixed dissolution composition (1)～(10)
B. mixed dissolution composition (11)～(17)
C. in A, add B, uniform mixing obtains astringent.
(embodiment 1-2: emulsifiable paste)
(composition) (%)
(1) Squalene 20.0
(2) Cera Flava 5.0
(3) heartily cling to oil 5.0
(4) glyceryl monostearate 2.0
(5) monostearate polyoxyethylene (20E.O.) sorbitan
2.0
Ester
(6) the monostearate sorbitan ester 2.0
(7) plant sterol * 1 0.5
(8) candelilla wax 1.0
(9) glycerol 5.0
(10) to oxybenzoic acid methyl ester 0.1
(11) Bulbus Lilii extract * 2 1.0
(12) Radix Ginseng extract * 3 1.0
(13) Semen Ginkgo extrac * 4 1.0
(14) the Fructus Jujubae collection is carried thing * 5 1.0
(15) Radix Sophorae Flavescentis (Network ラ ラ) extract * 6 1.0
(16) hydrolysis rice extracts * 7 1.0
(17) Radix Glycyrrhizae extract * 8 1.0
(18) Radix Angelicae Sinensis extract * 9 1.0
(19) birch resin * 10 5.0
(20) Purified Water surplus
(21) spice is an amount of
* 1 carry (エ-ザ イ) society's system especially
* 2 balls are apt to pharmacy society system
* 3 balls are apt to pharmacy society system
* 4 society of normal huge rock fitochemical studies institute systems
* 5 balls are apt to pharmacy society system
* 6 balls are apt to pharmacy society system
* 7 Tai Kunuobu lands (テ Network ノ Block-Le) society's system
* 8 balls are apt to pharmacy society system
* 9 Japanese powder pharmaceutical society systems
* 10 Sapp (さ つ Bru) manufactured (Sen Shizuku)
(method for making)
A. heat blending constituent (1)～(10), remain on 70 ℃.
B. heat blending constituent (11)～(20), remain on 70 ℃.
C. in A, add B, carry out emulsifying.
D. after the cooling, in C, add composition (21) and the acquisition emulsifiable paste.
If embodiment 1-1 and embodiment 1-2 are applicable to any skin, then produce facilitation through profilaggrin and/or fiber polymeric protein, produce nature moisturizing factor at skin self, be the astringent and the emulsifiable paste that can continue to keep skin wet therefore.
(embodiment 1-3: facial milk cleanser)
(composition) (%)
(1) paraffin 10.0
(2) Cera Flava 3.0
(3) vaseline 15.0
(4) Liquid Paraffin 41.0
(5) sesquialter oleic acid acid sorbitan ester 4.2
(6) single oleic acid polyoxyethylene (20E.O.) sorbitan ester 0.8
(7) hydrogenated soya phosphatide matter 0.5
(8) the oily * 1 1.0 of a thick wood (メ De ウ ホ-system) that goes out
(9) to oxybenzoic acid methyl ester 0.1
(10) this west of storehouse mattress bucket (Network イ Application ス シ-De) extract * 2 1.0
(11) ZAOCAO extract * 3 1.0
(12) Sai Niaou clothing (ゼ ニ ア オ イ) extract * 4 1.0
(13) birch resin * 5 5.0
(14) Purified Water surplus
(15) spice is an amount of
* 1 Japanese Safa Ku Tantuo (Japanese サ-Off ア Network タ Application ト) society's system
* 2 fragrant Rong Xing leaf society systems
* 3 balls are apt to pharmacy society system
* 4 balls are apt to pharmacy society system
* 5 Sapp (さ つ Bru) manufactured (Sen Shizuku)
(method for making)
A. heat blending constituent (1)～(9), remain on 70 ℃.
B. heat blending constituent (10)～(14), remain on 70 ℃.
C. in A, add B, uniformly emulsify.
D. after the cooling, in C, add composition (15) and the acquisition facial milk cleanser.
Embodiment 1-3 is through being applicable to skin arbitrarily, thereby produces facilitation through profilaggrin and/or fiber polymeric protein, produces nature moisturizing factor at skin self, is the facial milk cleanser that can continue to keep skin wet therefore.
(embodiment 1-4: emulsion)
(composition) (%)
(1) the monostearate sorbitan ester 0.3
(2) single oil (モ ノ オ レ イ Application) sour polyoxyethylene (20E.O.)
0.1
Sorbitan ester
(3) the lipophilic glyceryl monostearate 0.2
(4) stearic acid 0.5
(5) spermol 0.5
(6) Squalene 3.0
(7) Liquid Paraffin 4.0
(8) vegetalitas Squalene * 1 0.2
(9) three-2-ethyl hexane acid glycerides 2.0
(10) dimethyl polysiloxane 1.0
(11) hydrogenated soya phosphatide matter 0.1
(12) nicotinic acid dl-alpha-tocopherol * 2 0.05
(13) to oxybenzoic acid methyl ester 0.1
(14) CVP Carbopol ETD2050 0.1
(15) sodium hydroxide 0.05
(16) glycerol 5.0
(17) 1,3 butylene glycol 7.0
(18) ethanol 5.0
(19) birch resin * 3 10.0
(20) Radix Paeoniae Alba extract * 4 2.0
(21) Ganoderma extract * 5 2.0
(22) hyaluronate sodium 1% aqueous solution * 6 5.0
(23) acetyl group glutamic acid * 7 0.3
(24) Purified Water surplus
(25) porous silica 3.0
(26) spice is an amount of
* purple (daylight ケ ミ カ Le ズ) society's system in 1 daylight Kai Mika land
* 2 fill in (エ-ザ イ) society's system especially
* 3 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* 4 balls are apt to pharmacy society system
* 5 balls are apt to pharmacy society system
* purple (daylight ケ ミ カ Le ズ) society's system in 6 daylight Kai Mika lands
* 7 consonance fermentation society systems
(method for making)
A. heat blending constituent (14)～(23), remain on 70 ℃.
B. heat blending constituent (1)～(13), remain on 70 ℃.
C. in A, add B, uniformly emulsify.
D. after the cooling, in C, add composition (24), (25), (26) and obtain emulsion.
(embodiment 1-5: emulsion)
(composition) (%)
(1) the monostearate sorbitan ester 0.3
(2) single oil (モ ノ オ レ イ Application) sour polyoxyethylene (20E.O.)
0.1
Sorbitan ester
(3) the lipophilic glyceryl monostearate 0.2
(4) stearic acid 0.5
(5) spermol 0.5
(6) Squalene 3.0
(7) Liquid Paraffin 4.0
(8) three-2-ethyl hexane acid glycerides 2.0
(9) dimethyl polysiloxane 1.0
(10) hydrogenated soya phosphatide matter 0.1
(11) rutin * 1 0.2
(12) to oxybenzoic acid methyl ester 0.1
(13) CVP Carbopol ETD2050 0.1
(14) sodium hydroxide 0.05
(15) glycerol 5.0
(16) 1,3 butylene glycol 7.0
(17) birch resin * 2 3.0
(18) Purified Water surplus
(19) ethanol 5.0
(20) yeast extract extract * 3 0.5
(21) A Mitaba (ア ミ タ バ) extract * 4 0.5
(22) hops extract * 5 0.5
(23) peach extract * 6 0.5
(24) porous silica 3.0
(25) spice is an amount of
* 1 Xi Kuma (シ グ マ) society's system
* 2 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* 3BIO-DELL social system (Sen Shizuku)
* 4 balls are apt to pharmacy society system
* 5 balls are apt to pharmacy society system
* 6 balls are apt to pharmacy society system
(method for making)
A. heat blending constituent (13)～(23), remain on 70 ℃.
B. heat blending constituent (1)～(12), remain on 70 ℃.
C. in A, add B, uniformly emulsify.
D. after the cooling, in C, add composition (24), (25) and obtain emulsion.
Embodiment 1-4 and embodiment 1-5 be through being applicable to skin arbitrarily, thereby produce facilitation through profilaggrin and/or fiber polymeric protein, produces nature moisturizing factor at skin self, is the emulsion that can continue to keep skin wet therefore.
(embodiment 1-6: facial film)
(composition) (%)
(1) polyvinyl alcohol 15.0
(2) anhydrous silicic acid 0.5
(3) polyethylene glycol 1500 0.5
(4) the oily * 1 0.2 of a thick wood (メ De ウ ホ-system) that goes out
(5) polyoxypropylene (10P.O.) glucosides 5.0
(6) glycerol 5.0
(7) Purified Water surplus
(8) tea extract * 2 1.0
(9) sweetbrier polyantha extract * 3 1.0
(10) Caffeine Anhydrous * 4 1.0
(11) birch resin * 5 5.0
(12) phosphoric acid-L-vitamin C (Ascorbyl) magnesium * 6 3.0
(13) Purified Water 5.0
(14) ethanol 18.0
(15) to oxybenzoic acid ethyl ester 0.1
(16) spice is an amount of
* 1 Japanese Safa Ku Tantuo (Japanese サ-Off ア Network タ Application ト) society's system
* 2 balls are apt to pharmacy society system
* 3 balls are apt to pharmacy society system
* 4 pure pharmaceutical industries society systems
* 5 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* purple (daylight ケ ミ カ Le ズ) society's system in 6 daylight Kai Mika lands
(method for making)
A. blending constituent (1)～(7) are heated to 70 ℃ of dissolvings.
B. mixed dissolution composition (8)～(13).
C. mixed dissolution composition (14)～(16).
D. in A, add B, mix postcooling, add C, mix, obtain facial film.
Embodiment 1-6 is through being applicable to skin, thereby produces facilitation through profilaggrin and/or fiber polymeric protein, produces nature moisturizing factor at skin self, is the facial film that can continue to keep skin wet therefore.
(embodiment 1-7: vanishing cream)
(composition) (%)
(1) sesquialter oleic acid acid sorbitan ester 3.0
(2) the self-emulsifying type glyceryl monostearate 2.0
(3) aluminium stearate 0.5
(4) ceresine 5.0
(5) Squalene 10.0
(6) Liquid Paraffin 15.0
(7) vaseline 5.0
(8) titanium oxide 8.0
(9) clay 4.0
(10) coloring pigment is an amount of
(11) to oxybenzoic acid methyl ester 0.05
(12) propylene glycol 5.0
(13) Flos Lonicerae extract * 1 1.0
(14) Betula platyphylla Suk. extract * 2 1.0
(15) Aesculus hippocastanum extract * 3 1.0
(16) birch resin * 4 10.0
(17) Purified Water surplus
(18) spice is an amount of
* 1 Changgong society of spice society system
* 2 balls are apt to pharmacy society system
* 3 fragrant Rong Xing leaf society systems
* 4 Sapp (さ つ Bru) manufactured (Sen Shizuku)
(method for making)
A. heat blending constituent (1)～(11), remain on 70 ℃.
B. heat blending constituent (12)～(17), remain on 70 ℃.
C. in A, add B, uniformly emulsify.
D. after the cooling, in C, add composition (18) and the acquisition vanishing cream.
(embodiment 1-8: foundation emulsion)
(composition) (%)
(1) aqueous agnolin 2.0
(2) Liquid Paraffin 5.0
(3) stearic acid 2.0
(4) spermol 1.0
(5) the self-emulsifying type glyceryl monostearate 1.0
(6) p-methoxycinnamic acid-(2-ethylhexyl) ester 8.0
(7) the 4-tert-butyl group-4 '-methoxy dibenzoyl methylmethane 2.0
(8) palmitic acid retinal * 1 0.2
(9) to oxybenzoic acid methyl ester 0.1
(10) glycerol 5.0
(11) triethanolamine 1.0
(12) carboxy methyl cellulose 0.2
(13) bentonite 0.5
(14) Betula platyphylla Suk. extracting solution * 2 5.0
(15) mannitol * 3 0.1
(16) Purified Water surplus
(17) titanium oxide 6.0
(18) particulate titanium dioxide 2.0
(19) particulate oxide zinc 5.0
(20) Muscovitum 2.0
(21) Talcum 4.0
(22) coloring pigment 4.0
(23) birch resin * 4 5.0
(24) Germinatus Phragmitis extract * 5 0.5
(25) Radix Glycyrrhizae extract * 6 0.5
(26) spice is an amount of
* (Japanese ロ シ ユ) the society's system of repairing is revealed by 1 Japan
* 2 balls are apt to pharmacy society system
* agate (シ グ マ) society's systems are consolidated in 3 west
* 4 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* 5 balls are apt to pharmacy society system
* 6 balls are apt to pharmacy society system
(method for making)
A. mixed dissolution composition (1)～(9).
B. in A, add composition (17)～(22), uniform mixing remains on 70 ℃.
C. uniform dissolution composition (10)～(16) remain on 70 ℃.
D. in C, add B, uniformly emulsify.
E. after cooling off D, adding ingredient (23)～(26) and obtain foundation emulsion.
(embodiment 1-9: ultra light sun block lotion)
(composition) (%)
(1) polyoxy alkylidene modification organopolysiloxane 1.0
(2) dimethyl polysiloxane 5.0
(3) octamethylcy-clotetrasiloxane 20.0
(4) different n-nonanoic acid isotridecyl ester 5.0
(5) p-methoxycinnamic acid-(2-ethylhexyl) ester 5.0
(6) to oxybenzoic acid methyl ester 0.1
(7) the silica-treated particulate titanium dioxide 10.0
(8) silica-treated particulate oxide zinc 10.0
(9) polyethylene powders 3.0
(10) trimethylsiloxy silicic acid 0.5
(11) dipropylene glycol 3.0
(12) ethanol 10.0
(13) birch resin * 1 10.0
(14) Sal 0.2
(15) Purified Water surplus
(16) beta-carotene * 2 0.01
(17) chamomile extract * 3 1.0
(18) small burnet extract * 4 1.0
(19) spice is an amount of
* 1 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* agate (シ グ マ) society's systems are consolidated in 2 west
* 3 balls are apt to pharmacy society system
* 4 balls are apt to pharmacy society system
(method for making)
A. blending constituent (1)～(10) remain on 70 ℃.
B. blending constituent (11)～(15) remain on 70 ℃.
C. in A, add B, uniformly emulsify.
D. after the cooling, in C, add composition (16)～(19) and the acquisition ultra light sun block lotion.
Embodiment 1-7～9 are through being applicable to all skins; Thereby produce facilitation through profilaggrin and/or fiber polymeric protein; Producing nature moisturizing factor at skin self, is vanishing cream, foundation emulsion and the ultra light sun block lotion that can continue to keep skin wet therefore.
(embodiment 2-1: astringent)
(composition) (%)
(1) glycerol 3.0
(2) 1,3 butylene glycol 2.0
(3) propylene glycol 4.0
(4) oleyl alcohol 0.1
(5) mono laurate polyoxyethylene (20E.O.) dehydration sorbose
1.5
Alcohol ester
(6) polyoxyethylene (20E.O.) lauryl ether 0.5
(7) Squalene 0.5
(8) ethanol 20.0
(9) to oxybenzoic acid methyl ester 0.1
(10) acetic acid dl-alpha-tocopherol * 1 0.5
(11) glycyrrhizic acid dicalcium * 2 0.5
(12) Herba Rosmarini Officinalis extract * 3 0.5
(13) dl-pyrrolidone sodium carboxylate liquid * 4 0.2
(14) tracasol 1.0
(15) Semen Coicis extract * 5 0.5
(16) birch resin * 6 20.0
(17) Purified Water surplus
* 1 fills in (エ-ザ イ) society's system especially
* 2 balls are apt to pharmacy society system
* 3 balls are apt to pharmacy society system
* () of 4 flavors plain society makes
* 5 balls are apt to pharmacy society system
* 6 Sapp (さ つ Bru) manufactured (Sen Shizuku)
(method for making)
A. mixed dissolution composition (1)～(10)
B. mixed dissolution composition (11)～(17)
C. in A, add B, uniform mixing obtains astringent.
(embodiment 2-2: emulsifiable paste)
(composition) (%)
(1) Squalene 20.0
(2) Cera Flava 5.0
(3) heartily cling to oil 5.0
(4) glyceryl monostearate 2.0
(5) monostearate polyoxyethylene (20E.O.) sorbitan
2.0
Ester
(6) the monostearate sorbitan ester 2.0
(7) plant sterol * 1 0.5
(8) candelilla wax 1.0
(9) glycerol 5.0
(10) to oxybenzoic acid methyl ester 0.1
(11) Bulbus Lilii extract * 2 1.0
(12) Radix Ginseng extract * 3 1.0
(13) Semen Ginkgo extrac * 4 1.0
(14) Fructus Jujubae extract * 5 1.0
(15) Radix Sophorae Flavescentis (Network ラ ラ) extract * 6 1.0
(16) hydrolysis rice extracts * 7 1.0
(17) Radix Glycyrrhizae extract * 8 1.0
(18) Radix Angelicae Sinensis extract * 9 1.0
(19) birch resin * 10 5.0
(20) Purified Water surplus
(21) spice is an amount of
* 1 fills in (エ-ザ イ) society's system especially
* 2 balls are apt to pharmacy society system
* 3 balls are apt to pharmacy society system
* 4 society of normal huge rock fitochemical studies institute systems
* 5 balls are apt to pharmacy society system
* 6 balls are apt to pharmacy society system
* 7 Tai Kunuobu lands (テ Network ノ Block-Le) society's system
* 8 balls are apt to pharmacy society system
* 9 balls are apt to pharmacy society system
* 10 Sapp (さ つ Bru) manufactured (Sen Shizuku)
(method for making)
A. heat blending constituent (1)～(10), remain on 70 ℃.
B. heat blending constituent (11)～(20), remain on 70 ℃.
C. in A, add B, carry out emulsifying.
After the D.C cooling, in C, add composition (21) and mix, and obtain emulsifiable paste.
Embodiment 2-1 and embodiment 2-2 are through being applicable to any skin; Make in the barrier functionality normalization of skin surface thereby produce facilitation, therefore be that the moisture of skin surface keeps improving effect, prevent astringent and emulsifiable paste that the pachylosis effect is excellent through Envelope.
(embodiment 2-3: facial milk cleanser)
(composition) (%)
(1) paraffin 10.0
(2) Cera Flava 3.0
(3) vaseline 15.0
(4) Liquid Paraffin 41.0
(5) sesquialter oleic acid acid sorbitan ester 4.2
(6) single oil (モ ノ オ レ イ Application) sour polyoxyethylene (20E.O.)
0.8
Sorbitan ester
(7) hydrogenated soya phosphatide matter 0.5
(8) the oily * 1 1.0 of a thick wood (メ De ウ ホ-system) that goes out
(9) to oxybenzoic acid methyl ester 0.1
(10) this west of storehouse mattress bucket (Network イ Application ス シ-De) extract * 2 1.0
(11) ZAOCAO extract * 3 1.0
(12) Sai Niaou clothing (ゼ ニ ア オ イ) extract * 4 1.0
(13) birch resin * 5 5.0
(14) Purified Water surplus
(15) spice is an amount of
* 1 Japanese Safa Ku Tantuo (Japanese サ-Off ア Network タ Application ト) society's system
* 2 fragrant Rong Xing leaf society systems
* 3 balls are apt to pharmacy society system
* 4 balls are apt to pharmacy society system
* 5 Sapp (さ つ Bru) manufactured (Sen Shizuku)
(method for making)
A. heat blending constituent (1)～(9), remain on 70 ℃.
B. heat blending constituent (10)～(14), remain on 70 ℃.
C. in A, add B, uniformly emulsify.
D. after cooling off C, in C, add composition (15) and mix, and obtain facial milk cleanser.
Embodiment 2-3 makes in the barrier functionality normalization of skin surface thereby produce facilitation through Envelope through being applicable to any skin, therefore is that the moisture of skin surface keeps improving effect, prevents the facial milk cleanser that the pachylosis effect is excellent.
(embodiment 2-4: emulsion)
(composition) (%)
(1) the monostearate sorbitan ester 0.3
(2) single oil (モ ノ オ レ イ Application) sour polyoxyethylene (20E.O.)
0.1
Sorbitan ester
(3) the lipophilic glyceryl monostearate 0.2
(4) stearic acid 0.5
(5) spermol 0.5
(6) Squalene 3.0
(7) Liquid Paraffin 4.0
(8) vegetalitas Squalene * 1 0.2
(9) three-2-ethyl hexane acid glycerides 2.0
(10) dimethyl polysiloxane 1.0
(11) hydrogenated soya phosphatide matter 0.1
(12) nicotinic acid dl-alpha-tocopherol * 2 0.05
(13) to oxybenzoic acid methyl ester 0.1
(14) CVP Carbopol ETD2050 0.1
(15) sodium hydroxide 0.05
(16) glycerol 5.0
(17) 1,3 butylene glycol 7.0
(18) ethanol 5.0
(19) birch resin * 3 10.0
(20) Radix Paeoniae Alba extract * 4 2.0
(21) Ganoderma extract * 5 2.0
(22) hyaluronate sodium 1% aqueous solution * 6 5.0
(23) acetyl group glutamic acid * 7 0.3
(24) Purified Water surplus
(25) porous silica 3.0
(26) spice is an amount of
* purple (daylight ケ ミ カ Le ズ) society's system in 1 daylight Kai Mika land
* 2 fill in (エ-ザ イ) society's system especially
* 3 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* 4 balls are apt to pharmacy society system
* 5 balls are apt to pharmacy society system
* purple (daylight ケ ミ カ Le ズ) society's system in 6 daylight Kai Mika lands
* 7 consonance fermentation society systems
(method for making)
A. heat blending constituent (14)～(24), remain on 70 ℃.
B. heat blending constituent (1)～(13), remain on 70 ℃.
C. in A, add B and mix uniformly emulsify.
After the D.C cooling, in C, add composition (25), (26) mixing, and obtain emulsion.
(embodiment 2-5: emulsion)
(composition) (%)
(1) the monostearate sorbitan ester 0.3
(2) single oil (モ ノ オ レ イ Application) sour polyoxyethylene (20E.O.)
0.1
Sorbitan ester
(3) the lipophilic glyceryl monostearate 0.2
(4) stearic acid 0.5
(5) spermol 0.5
(6) Squalene 3.0
(7) Liquid Paraffin 4.0
(8) three-2-ethyl hexane acid glycerides 2.0
(9) dimethyl polysiloxane 1.0
(10) hydrogenated soya phosphatide matter 0.1
(11) rutin * 1 0.2
(12) to oxybenzoic acid methyl ester 0.1
(13) CVP Carbopol ETD2050 0.1
(14) sodium hydroxide 0.05
(15) glycerol 5.0
(16) 1,3 butylene glycol 7.0
(17) birch resin * 2 3.0
(18) Purified Water surplus
(19) ethanol 5.0
(20) yeast extract * 3 0.5
(21) A Mitaba (ア ミ タ バ) extract * 4 0.5
(22) hops extract * 5 0.5
(23) peach extract * 6 0.5
(24) porous silica 3.0
(25) spice is an amount of
* agate (シ グ マ) society's system is consolidated in 1 west
* 2 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* 3BIO-DELL social system (Sen Shizuku)
* 4 balls are apt to pharmacy society system
* 5 balls are apt to pharmacy society system
* 6 balls are apt to pharmacy society system
(method for making)
A. heat blending constituent (13)～(23), remain on 70 ℃.
B. heat blending constituent (1)～(12), remain on 70 ℃.
C. in A, add B and mix uniformly emulsify.
After the D.C cooling, in C, add composition (24), (25) mixing, and obtain emulsion.
Embodiment 2-4 and embodiment 2-5 are through being applicable to any skin; Make in the barrier functionality normalization of skin surface thereby produce facilitation, therefore be that the moisture of skin surface keeps improving effect, prevent the emulsion that the pachylosis effect is excellent through Envelope.
(embodiment 2-6: facial film)
(composition) (%)
(1) polyvinyl alcohol 15.0
(2) anhydrous silicic acid 0.5
(3) Polyethylene Glycol 0.5
(4) the oily * 1 0.2 of a thick wood (メ De ウ ホ-system) that goes out
(5) polyoxypropylene (10P.O.) glucosides 5.0
(6) glycerol 5.0
(7) Purified Water surplus
(8) tea extract * 2 1.0
(9) sweetbrier polyantha extract * 3 1.0
(10) Caffeine Anhydrous * 4 1.0
(11) birch resin * 5 5.0
(12) phosphoric acid-L-vitamin C (Ascorbyl) magnesium * 6 3.0
(13) Purified Water 5.0
(14) ethanol 15.0
(15) to oxybenzoic acid ethyl ester 0.1
(16) spice surplus
* 1 Japanese Safa Ku Tantuo (Japanese サ-Off ア Network タ Application ト) society's system
* 2 balls are apt to pharmacy society system
* 3 balls are apt to pharmacy society system
* 4 pure pharmaceutical industries society systems
* 5 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* purple (daylight ケ ミ カ Le ズ) society's system in 6 daylight Kai Mika lands
(method for making)
A. blending constituent (1)～(7) are heated to 70 ℃ of dissolvings.
B. mixed dissolution composition (8)～(13).
C. mixed dissolution composition (14)～(16).
D. in A, add B, mix postcooling, add C, mix, obtain facial film.
Embodiment 2-6 makes in the barrier functionality normalization of skin surface thereby produce facilitation through Envelope through being applicable to skin, therefore is that the moisture of skin surface keeps improving effect, prevents that the pachylosis effect is excellent
(embodiment 2-7: vanishing cream)
(composition) (%)
(1) sesquialter oleic acid acid sorbitan ester 3.0
(2) the self-emulsifying type glyceryl monostearate 2.0
(3) aluminium stearate 0.5
(4) ceresine 5.0
(5) Squalene 10.0
(6) Liquid Paraffin 15.0
(7) vaseline 5.0
(8) titanium oxide 8.0
(9) clay 4.0
(10) coloring pigment is an amount of
(11) to oxybenzoic acid methyl ester 0.05
(12) propylene glycol 5.0
(13) Flos Lonicerae extract * 1 1.0
(14) Betula platyphylla Suk. extract * 2 1.0
(15) Aesculus hippocastanum extract * 3 1.0
(16) birch resin * 4 10.0
(17) Purified Water surplus
(18) spice is an amount of
* 1 Changgong society of spice society system
* 2 balls are apt to pharmacy society system
* 3 fragrant Rong Xing leaf society systems
* 4 Sapp (さ つ Bru) manufactured (Sen Shizuku)
(method for making)
A. heat blending constituent (1)～(11), remain on 70 ℃.
B. heat blending constituent (12)～(17), remain on 70 ℃.
C. in A, add B and mix uniformly emulsify.
After the D.C cooling, in C, add composition (18) and mix, and obtain vanishing cream.
(embodiment 2-8: foundation emulsion)
(composition) (%)
(1) aqueous agnolin 2.0
(2) Liquid Paraffin 5.0
(3) stearic acid 2.0
(4) spermol 1.0
(5) the self-emulsifying type glyceryl monostearate 1.0
(6) p-methoxycinnamic acid-(2-ethylhexyl) ester 8.0
(7) the 4-tert-butyl group-4 '-methoxy dibenzoyl methylmethane 2.0
(8) palmitic acid retinal * 1 0.2
(9) to oxybenzoic acid methyl ester 0.1
(10) glycerol 5.0
(11) triethanolamine 1.0
(12) carboxy methyl cellulose 0.2
(13) bentonite 0.5
(14) Betula platyphylla Suk. resin * 2 5.0
(15) mannitol * 3 0.1
(16) Purified Water surplus
(17) titanium oxide 6.0
(18) particulate titanium dioxide 2.0
(19) particulate oxide zinc 5.0
(20) Muscovitum 2.0
(21) Talcum 4.0
(22) coloring pigment 4.0
(23) birch resin * 4 5.0
(24) Germinatus Phragmitis extract * 5 0.5
(25) Radix Glycyrrhizae extract * 6 0.5
(26) spice is an amount of
* (Japanese ロ シ ユ) the society's system of repairing is revealed by 1 Japan
* 2 balls are apt to pharmacy society system
* agate (シ グ マ) society's systems are consolidated in 3 west
* 4 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* 5 balls are apt to pharmacy society system
* 6 balls are apt to pharmacy society system
(method for making)
A. mixed dissolution composition (1)～(9).
B. in A, add composition (17)～(22), uniform mixing remains on 70 ℃.
C. uniform dissolution composition (10)～(16) remain on 70 ℃.
D. in C, add B, uniformly emulsify.
E. after cooling off D, mix adding ingredient (23)～(26), and obtain foundation emulsion.
(embodiment 2-9: ultra light sun block lotion)
(composition) (%)
(1) polyoxy alkylidene modification organopolysiloxane 1.0
(2) dimethyl polysiloxane 5.0
(3) octamethylcy-clotetrasiloxane 20.0
(4) different n-nonanoic acid isotridecyl ester 5.0
(5) p-methoxycinnamic acid-(2-ethylhexyl) ester 5.0
(6) to oxybenzoic acid methyl ester 0.1
(7) polysiloxanes (シ リ コ one Application) is handled particulate titanium dioxide 10.0
(8) polysiloxanes (シ リ コ one Application) is handled particulate oxide zinc 10.0
(9) polyethylene powders 3.0
(10) trimethylsiloxy silicic acid 0.5
(11) dipropylene glycol 3.0
(12) ethanol 10.0
(13) birch resin * 1 10.0
(14) Sal 0.2
(15) Purified Water surplus
(16) beta-carotene * 2 0.01
(17) chamomile extract * 3 1.0
(18) small burnet extract * 4 1.0
(19) spice is an amount of
* 1 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* agate (シ グ マ) society's systems are consolidated in 2 west
* 3 balls are apt to pharmacy society system
* 4 balls are apt to pharmacy society system
(method for making)
A. blending constituent (1)～(10) remain on 70 ℃.
B. mixed dissolution (11)～(15) remain on 70 ℃.
C. in A, add B, uniformly emulsify.
After the D.C cooling, in C, add composition (16)～(19) and mix, and obtain vanishing cream.
Embodiment 2-7～9 are through being applicable to any skin; Make in the barrier functionality normalization of skin surface thereby produce facilitation, therefore be that the moisture of skin surface keeps improving effect, prevent vanishing cream, foundation emulsion and ultra light sun block lotion that the pachylosis effect is excellent through Envelope.
(embodiment 3-1: astringent)
(composition) (%)
(1) glycerol 3.0
(2) 1,3 butylene glycol 2.0
(3) propylene glycol 4.0
(4) oleyl alcohol 0.1
(5) mono laurate polyoxyethylene (20E.O.) dehydration sorbose
1.5
Alcohol ester
(6) polyoxyethylene (20E.O.) lauryl ether 0.5
(7) Squalene 0.5
(8) ethanol 20.0
(9) to oxybenzoic acid methyl ester 0.1
(10) acetic acid dl-alpha-tocopherol * 1 0.5
(11) spice is an amount of
(12) glycyrrhizic acid dicalcium * 2 0.5
(13) Herba Rosmarini Officinalis extract * 3 0.5
(14) dl-pyrrolidone sodium carboxylate liquid * 4 0.2
(15) tracasol 1.0
(16) Semen Coicis extract * 5 0.5
(17) birch resin * 6 20.0
(18) Purified Water surplus
* 1 fills in (エ-ザ イ) society's system especially
* 2 balls are apt to pharmacy society system
* 3 balls are apt to pharmacy society system
* () of 4 flavors plain society makes
* 5 balls are apt to pharmacy society system
* 6 Sapp (さ つ Bru) manufactured (Sen Shizuku)
(method for making)
A. mixed dissolution composition (1)～(11)
B. mixed dissolution composition (12)～(18)
C. in A, add B, uniform mixing obtains astringent.
Embodiment 3-1 has fresh salubrious usability, makes skin wet, is the astringent that can continue to keep skin wet.
(embodiment 3-2: emulsifiable paste)
(composition) (%)
(1) Squalene 20.0
(2) Cera Flava 5.0
(3) heartily cling to oil 5.0
(4) glyceryl monostearate 2.0
(5) monostearate polyoxyethylene (20E.O.) sorbitan
2.0
Ester
(6) the monostearate sorbitan ester 2.0
(7) plant sterol * 1 0.5
(8) candelilla wax 1.0
(9) glycerol 5.0
(10) to oxybenzoic acid methyl ester 0.1
(11) Bulbus Lilii extract * 2 1.0
(12) Radix Ginseng extract * 3 1.0
(13) Semen Ginkgo extrac * 4 1.0
(14) Fructus Jujubae extract * 5 1.0
(15) Radix Sophorae Flavescentis (Network ラ ラ) extract * 6 1.0
(16) hydrolysis rice extracts * 7 1.0
(17) Radix Glycyrrhizae extract * 8 1.0
(18) Radix Angelicae Sinensis extract * 9 1.0
(19) birch resin * 10 5.0
(20) Purified Water surplus
(21) spice is an amount of
* 1 fills in (エ-ザ イ) society's system especially
* 2 balls are apt to pharmacy society system
* 3 balls are apt to pharmacy society system
* 4 society of normal huge rock fitochemical studies institute systems
* 5 balls are apt to pharmacy society system
* 6 balls are apt to pharmacy society system
* 7 Tai Kunuobu lands (テ Network ノ Block-Le) society's system
* 8 balls are apt to pharmacy society system
* 9 Japanese powder pharmaceutical society systems
* 10 Sapp (さ つ Bru) manufactured (Sen Shizuku)
(method for making)
A. heat blending constituent (1)～(10), remain on 70 ℃.
B. heat blending constituent (11)～(20), remain on 70 ℃.
C. in A, add B, carry out emulsifying.
After the D.C cooling, in C, add composition (21) and mix, and obtain emulsifiable paste.
Embodiment 3-2 has smooth dense usability, and can make skin wet and give softness (エ モ リ エ Application ト) sense, be the emulsifiable paste that can continue to keep skin wet.
(embodiment 3-3: facial milk cleanser)
(composition) (%)
(1) paraffin 10.0
(2) Cera Flava 3.0
(3) vaseline 15.0
(4) Liquid Paraffin 41.0
(5) sesquialter oleic acid acid sorbitan ester 4.2
(6) single oleic acid polyoxyethylene (20E.O.) sorbitan ester 0.8
(7) hydrogenated soya phosphatide matter 0.5
(8) the oily * 1 1.0 of a thick wood (メ De ウ ホ-system) that goes out
(9) to oxybenzoic acid methyl ester 0.1
(10) this west of storehouse mattress bucket (Network イ Application ス シ-De) extract * 2 1.0
(11) ZAOCAO extract * 3 1.0
(12) Sai Niaou clothing (ゼ ニ ア オ イ) extract * 4 1.0
(13) birch resin * 5 5.0
(14) Purified Water surplus
(15) spice is an amount of
* 1 Japanese Safa Ku Tantuo (Japanese サ-Off ア Network タ Application ト) society's system
* 2 fragrant Rong Xing leaf society systems
* 3 balls are apt to pharmacy society system
* 4 balls are apt to pharmacy society system
* 5 Sapp (さ つ Bru) manufactured (Sen Shizuku)
(method for making)
A. heat blending constituent (1)～(9), remain on 70 ℃.
B. heat blending constituent (10)～(14), remain on 70 ℃.
C. in A, add B, uniformly emulsify.
After the D.C cooling, in C, add composition (15) and mix, and obtain facial milk cleanser.
Embodiment 3-3 has the usability of light cunning, if exist dirt also can well remove, is the facial milk cleanser that after clean, can continue to keep skin wet.
(embodiment 3-4: emulsion)
(composition) (%)
(1) the monostearate sorbitan ester 0.3
(2) single oleic acid polyoxyethylene (20E.O.) sorbitan ester 0.1
(3) the lipophilic glyceryl monostearate 0.2
(4) stearic acid 0.5
(5) spermol 0.5
(6) Squalene 3.0
(7) Liquid Paraffin 4.0
(8) vegetalitas Squalene * 1 0.2
(9) three-2-ethyl hexane acid glycerides 2.0
(10) dimethyl polysiloxane 1.0
(11) hydrogenated soya phosphatide matter 0.1
(12) nicotinic acid dl-alpha-tocopherol * 2 0.05
(13) to oxybenzoic acid methyl ester 0.1
(14) CVP Carbopol ETD2050 0.1
(15) sodium hydroxide 0.05
(16) glycerol 5.0
(17) 1,3 butylene glycol 7.0
(18) Purified Water surplus
(19) birch resin * 3 10.0
(20) Radix Paeoniae Alba extract * 4 2.0
(21) Ganoderma extract * 5 2.0
(22) hyaluronate sodium 1% aqueous solution * 6 5.0
(23) acetyl group glutamic acid * 7 0.3
(24) porous silica 3.0
(25) spice is an amount of
(26) ethanol 5.0
* purple (daylight ケ ミ カ Le ズ) society's system in 1 daylight Kai Mika land
* 2 fill in (エ-ザ イ) society's system especially
* 3 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* 4 balls are apt to pharmacy society system
* 5 balls are apt to pharmacy society system
* purple (daylight ケ ミ カ Le ズ) society's system in 6 daylight Kai Mika lands
* 7 consonance fermentation society systems
(method for making)
A. heat blending constituent (14)～(23), remain on 70 ℃.
B. heat blending constituent (1)～(13), remain on 70 ℃.
C. in A, add B, uniformly emulsify.
After the D.C cooling, in C, add composition (24), (25), (26) mixing, and obtain emulsion.
(embodiment 3-5: emulsion)
(composition) (%)
(1) the monostearate sorbitan ester 0.3
(2) single oleic acid polyoxyethylene (20E.O.) sorbitan ester 0.1
(3) the lipophilic glyceryl monostearate 0.2
(4) stearic acid 0.5
(5) spermol 0.5
(6) Squalene 3.0
(7) Liquid Paraffin 4.0
(8) three-2-ethyl hexane acid glycerides 2.0
(9) dimethyl polysiloxane 1.0
(10) hydrogenated soya phosphatide matter 0.1
(11) rutin * 1 0.2
(12) to oxybenzoic acid methyl ester 0.1
(13) CVP Carbopol ETD2050 0.1
(14) sodium hydroxide 0.05
(15) glycerol 5.0
(16) 1,3 butylene glycol 7.0
(17) birch resin * 2 3.0
(18) Purified Water surplus
(19) yeast extract * 3 0.5
(20) A Mitaba (ア ミ タ バ) extract * 4 0.5
(21) hops extract * 5 0.5
(22) peach extract * 6 0.5
(23) porous silica 3.0
(24) spice is an amount of
(25) ethanol 5.0
* agate (シ グ マ) society's system is consolidated in 1 west
* 2 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* 3BIO-DELL social system (Sen Shizuku)
* 4 balls are apt to pharmacy society system
* 5 balls are apt to pharmacy society system
* 6 balls are apt to pharmacy society system
(method for making)
A. heat blending constituent (13)～(22), remain on 70 ℃.
B. heat blending constituent (1)～(12), remain on 70 ℃.
C. in A, add B, uniformly emulsify.
After the D.C cooling, in C, add composition (23), (24), (25) mixing, and obtain emulsion.
The usability that embodiment 3-4 and embodiment 3-5 have smooth gentleness can make skin wet and give appropriate softness (エ モ リ エ Application ト) sense, is the emulsion that can continue to keep skin wet.
(embodiment 3-6: facial film)
(composition) (%)
(1) polyvinyl alcohol 13.0
(2) anhydrous silicic acid 0.5
(3) Polyethylene Glycol 0.5
(4) the oily * 1 0.2 of a thick wood (メ De ウ ホ-system) that goes out
(5) polyoxypropylene (10P.O.) glucosides 5.0
(6) glycerol 5.0
(7) Purified Water surplus
(8) tea extract * 2 1.0
(9) sweetbrier polyantha extract * 3 1.0
(10) Caffeine Anhydrous * 4 1.0
(11) birch resin * 5 5.0
(12) phosphoric acid-L-vitamin C (Ascorbyl) magnesium * 6 3.0
(13) to oxybenzoic acid ethyl ester 0.1
(14) ethanol 20.0
(15) spice is an amount of
* 1 Japanese Safa Ku Tantuo (Japanese サ-Off ア Network タ Application ト) industrial society system
* 2 balls are apt to pharmacy society system
* 3 balls are apt to pharmacy society system
* 4 pure pharmaceutical industries society systems
* 5 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* purple (daylight ケ ミ カ Le ズ) society's system in 6 daylight Kai Mika lands
(method for making)
A. blending constituent (1)～(7) are heated to 70 ℃ of dissolvings.
B. mixed dissolution composition (8)～(12).
C. mixed dissolution composition (13)～(15).
D. in A, add B, mix postcooling, add C, mix, obtain facial film.
Embodiment 3-6 has the refrigerant sense and the tight sense of appropriateness, behind flush coat, obtains moistening and tension sense, is the facial film that can continue to keep skin wet.
(embodiment 3-7: vanishing cream)
(composition) (%)
(1) sesquialter oleic acid acid sorbitan ester 3.0
(2) the self-emulsifying type glyceryl monostearate 2.0
(3) aluminium stearate 0.5
(4) ceresine 5.0
(5) Squalene 10.0
(6) Liquid Paraffin 15.0
(7) vaseline 5.0
(8) titanium oxide 8.0
(9) clay 4.0
(10) coloring pigment is an amount of
(11) to oxybenzoic acid methyl ester 0.05
(12) propylene glycol 5.0
(13) Flos Lonicerae extract * 1 1.0
(14) Betula platyphylla Suk. extract * 2 1.0
(15) Aesculus hippocastanum extract * 3 1.0
(16) birch resin * 4 10.0
(17) Purified Water surplus
(18) spice is an amount of
* 1 Changgong spice society system
* 2 balls are apt to pharmacy society system
* 3 fragrant Rong Xing leaf society systems
* 4 Sapp (さ つ Bru) manufactured (Sen Shizuku)
(method for making)
A. heat blending constituent (1)～(11), remain on 70 ℃.
B. heat blending constituent (12)～(17), remain on 70 ℃.
C. in A, add B, uniformly emulsify.
After the D.C cooling, in C, add composition (18) and mix, and obtain vanishing cream.
(embodiment 3-8: foundation emulsion)
(composition) (%)
(1) aqueous agnolin 2.0
(2) Liquid Paraffin 5.0
(3) stearic acid 2.0
(4) spermol 1.0
(5) the self-emulsifying type glyceryl monostearate 1.0
(6) p-methoxycinnamic acid-(2-ethylhexyl) ester 8.0
(7) the 4-tert-butyl group-4 '-methoxy dibenzoyl methylmethane 2.0
(8) palmitic acid retinal * 1 0.2
(9) to oxybenzoic acid methyl ester 0.1
(10) glycerol 5.0
(11) triethanolamine 1.0
(12) carboxy methyl cellulose 0.2
(13) bentonite 0.5
(14) Betula platyphylla Suk. resin * 2 5.0
(15) Purified Water surplus
(16) titanium oxide 6.0
(17) particulate titanium dioxide 2.0
(18) particulate oxide zinc 5.0
(19) Muscovitum 2.0
(20) Talcum 4.0
(21) coloring pigment 4.0
(22) mannitol * 3 0.1
(23) birch resin * 4 5.0
(24) Germinatus Phragmitis extract * 5 0.5
(25) Radix Glycyrrhizae extract * 6 0.5
(26) spice is an amount of
* (Japanese ロ シ ユ) the society's system of repairing is revealed by 1 Japan
* 2 balls are apt to pharmacy society system
* agate (シ グ マ) society's systems are consolidated in 3 west
* 4 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* 5 balls are apt to pharmacy society system
* 6 balls are apt to pharmacy society system
(method for making)
A. heating for dissolving composition (1)～(9).
B. in A, add composition (16)～(21), uniform mixing remains on 70 ℃.
C. heating for dissolving composition (10)～(15) remain on 70 ℃.
D. in C, add B, uniformly emulsify.
E. after cooling off D, mix and the acquisition foundation emulsion adding ingredient (22)～(26).
Embodiment 3-7 and embodiment 3-8 have dense smooth usability, are to obtain the result that evenly whitens, and this external enwergy continues to keep the vanishing cream and the foundation emulsion of skin wet.
(embodiment 3-9: ultra light sun block lotion)
(composition) (%)
(1) polyoxy alkylidene modification organopolysiloxane 1.0
(2) dimethyl polysiloxane 5.0
(3) octamethylcy-clotetrasiloxane 20.0
(4) different n-nonanoic acid isotridecyl ester 5.0
(5) p-methoxycinnamic acid-(2-ethylhexyl) ester 5.0
(6) to oxybenzoic acid methyl ester 0.1
(7) polysiloxanes is handled particulate titanium dioxide 10.0
(8) polysiloxanes is handled particulate oxide zinc 10.0
(9) polyethylene powders 3.0
(10) trimethylsiloxy silicic acid 0.5
(11) dipropylene glycol 3.0
(12) ethanol 10.0
(13) birch resin * 1 10.0
(14) Sal 0.2
(15) Purified Water surplus
(16) beta-carotene * 2 0.01
(17) chamomile extract * 3 1.0
(18) small burnet extract * 4 1.0
(19) spice is an amount of
* 1 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* agate (シ グ マ) society's systems are consolidated in 2 west
* 3 balls are apt to pharmacy society system
* 4 balls are apt to pharmacy society system
(method for making)
A. heat blending constituent (1)～(10), remain on 70 ℃.
B. heat blending constituent (11)～(15), remain on 70 ℃.
C. in A, add B, carry out emulsifying.
After the D.C cooling, in C, add composition (16)～(19) and mix, and obtain ultra light sun block lotion.
Embodiment 3-9 has the smooth usability that is not clamminess, and is under ultraviolet, to protect skin, continues to keep the ultra light sun block lotion of skin wet simultaneously.
(embodiment 4-1: astringent)
(composition) (%)
(1) glycerol 3.0
(2) 1,3 butylene glycol 2.0
(3) propylene glycol 4.0
(4) oleyl alcohol 0.1
(5) mono laurate polyoxyethylene (20E.O.) dehydration sorbose
1.5
Alcohol ester
(6) polyoxyethylene (20E.O.) lauryl ether 0.5
(7) Squalene 0.5
(8) ethanol 20.0
(9) to oxybenzoic acid methyl ester 0.1
(10) acetic acid dl-alpha-tocopherol * 1 0.5
(11) spice is an amount of
(12) glycyrrhizic acid dicalcium * 2 0.5
(13) Herba Rosmarini Officinalis extract * 3 0.5
(14) dl-pyrrolidone sodium carboxylate * 4 0.2
(15) tracasol 1.0
(16) Semen Coicis extract * 5 0.5
(17) birch resin * 6 20.0
(18) Purified Water surplus
* 1 fills in (エ-ザ イ) society's system especially
* 2 balls are apt to pharmacy society system
* 3 balls are apt to pharmacy society system
* () of 4 flavors plain society makes
* 5 balls are apt to pharmacy society system
* 6 Sapp (さ つ Bru) manufactured (Sen Shizuku)
(method for making)
A. mixed dissolution composition (1)～(11)
B. mixed dissolution composition (12)～(18)
C. in A, add B, uniform mixing obtains astringent.
Embodiment 4-1 has fresh salubrious usability, be can obtain not have skin whitening such as pachylosis and skin obfuscation astringent.
(embodiment 4-2: emulsifiable paste)
(composition) (%)
(1) Squalene 20.0
(2) Cera Flava 5.0
(3) heartily cling to oil 5.0
(4) glyceryl monostearate 2.0
(5) monostearate polyoxyethylene (20E.O.) sorbitan
2.0
Ester
(6) the monostearate sorbitan ester 2.0
(7) plant sterol * 1 0.5
(8) candelilla wax 1.0
(9) glycerol 5.0
(10) to oxybenzoic acid methyl ester 0.1
(11) Bulbus Lilii extract * 2 1.0
(12) Radix Ginseng extract * 3 1.0
(13) Semen Ginkgo extrac * 4 1.0
(14) Fructus Jujubae extract * 5 1.0
(15) Radix Sophorae Flavescentis (Network ラ ラ) extract * 6 1.0
(16) hydrolysis rice extracts * 7 1.0
(17) Radix Glycyrrhizae extract * 8 1.0
(18) Radix Angelicae Sinensis extract * 9 1.0
(19) birch resin * 10 5.0
(20) Purified Water surplus
(21) spice is an amount of
* 1 fills in (エ-ザ イ) society's system especially
* 2 balls are apt to pharmacy society system
* 3 balls are apt to pharmacy society system
* 4 society of normal huge rock fitochemical studies institute systems
* 5 balls are apt to pharmacy society system
* 6 balls are apt to pharmacy society system
* 7 Tai Kunuobu lands (テ Network ノ Block-Le) society's system
* 8 balls are apt to pharmacy society system
* 9 Japanese powder pharmaceutical society systems
* 10 Sapp (さ つ Bru) manufactured (Sen Shizuku)
(method for making)
A. heat blending constituent (1)～(10), remain on 70 ℃.
B. heat blending constituent (11)～(20), remain on 70 ℃.
C. in A, add B, carry out emulsifying.
After the D.C cooling, in C, add composition (21) and mix, and obtain emulsifiable paste.
Embodiment 4-2 has smooth usability, be can obtain not have skin whitening such as pachylosis and skin obfuscation emulsifiable paste.
(embodiment 4-3: facial milk cleanser)
(composition) (%)
(1) paraffin 10.0
(2) Cera Flava 3.0
(3) vaseline 15.0
(4) Liquid Paraffin 41.0
(5) sesquialter oleic acid acid sorbitan ester 4.2
(6) single oleic acid polyoxyethylene (20E.O.) sorbitan ester 0.8
(7) hydrogenated soya phosphatide matter 0.5
(8) the oily * 1 1.0 of a thick wood (メ De ウ ホ-system) that goes out
(9) to oxybenzoic acid methyl ester 0.1
(10) this west of storehouse mattress bucket (Network イ Application ス シ-De) extract * 2 1.0
(11) ZAOCAO extract * 3 1.0
(12) Sai Niaou clothing (ゼ ニ ア オ イ) extract * 4 1.0
(13) birch resin * 5 5.0
(14) Purified Water surplus
(15) spice is an amount of
* 1 Japanese Safa Ku Tantuo (Japanese サ-Off ア Network タ Application ト) industrial society system
* 2 fragrant Rong Xing leaf society systems
* 3 balls are apt to pharmacy society system
* 4 balls are apt to pharmacy society system
* 5 Sapp (さ つ Bru) manufactured (Sen Shizuku)
(method for making)
A. heat blending constituent (1)～(9), remain on 70 ℃.
B. heat blending constituent (10)～(14), remain on 70 ℃.
C. in A, add B, carry out emulsifying.
After the D.C cooling, in C, add composition (15) and mix, and obtain facial milk cleanser.
Embodiment 4-3 has the usability of light cunning, if exist dirt also can well remove, the dirt excellence that comes off is the facial milk cleanser that can obtain not have skin whitening such as pachylosis and skin obfuscation.
(embodiment 4-4: emulsion)
(composition) (%)
(1) the monostearate sorbitan ester 0.3
(2) single oleic acid polyoxyethylene (20E.O.) sorbitan ester 0.1
(3) the lipophilic glyceryl monostearate 0.2
(4) stearic acid 0.5
(5) spermol 0.5
(6) Squalene 3.0
(7) Liquid Paraffin 4.0
(8) vegetalitas Squalene * 1 0.2
(9) three-2-ethyl hexane acid glycerides 2.0
(10) dimethyl polysiloxane 1.0
(11) hydrogenated soya phosphatide matter 0.1
(12) nicotinic acid dl-alpha-tocopherol * 2 0.05
(13) to oxybenzoic acid methyl ester 0.1
(14) CVP Carbopol ETD2050 0.1
(15) sodium hydroxide 0.05
(16) glycerol 5.0
(17) 1,3 butylene glycol 7.0
(18) Purified Water surplus
(19) birch resin * 3 10.0
(20) Radix Paeoniae Alba extract * 4 2.0
(21) Ganoderma extract * 5 2.0
(22) hyaluronate sodium 1% aqueous solution * 6 5.0
(23) acetyl group glutamic acid * 7 0.3
(24) ethanol 5.0
(25) porous silica 3.0
(26) spice is an amount of
* purple (daylight ケ ミ カ Le ズ) society's system in 1 daylight Kai Mika land
* 2 fill in (エ-ザ イ) society's system especially
* 3 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* 4 balls are apt to pharmacy society system
* 5 balls are apt to pharmacy society system
* purple (daylight ケ ミ カ Le ズ) society's system in 6 daylight Kai Mika lands
* 7 consonance fermentation society systems
(method for making)
A. heat blending constituent (14)～(23), remain on 70 ℃.
B. heat blending constituent (1)～(13), remain on 70 ℃.
C. in A, add B, carry out emulsifying.
After the D.C cooling, in C, add composition (24), (25), (26) mixing, and obtain emulsion.
(embodiment 4-5: emulsion)
(composition) (%)
(1) the monostearate sorbitan ester 0.3
(2) single oleic acid polyoxyethylene (20E.O.) sorbitan ester 0.1
(3) the lipophilic glyceryl monostearate 0.2
(4) stearic acid 0.5
(5) spermol 0.5
(6) Squalene 3.0
(7) Liquid Paraffin 4.0
(8) three-2-ethyl hexane acid glycerides 2.0
(9) dimethyl polysiloxane 1.0
(10) hydrogenated soya phosphatide matter 0.1
(11) rutin * 1 0.2
(12) to oxybenzoic acid methyl ester 0.1
(13) CVP Carbopol ETD2050 0.1
(14) sodium hydroxide 0.05
(15) glycerol 5.0
(16) 1,3 butylene glycol 7.0
(17) birch resin * 2 3.0
(18) Purified Water surplus
(19) yeast extract * 3 0.5
(20) A Mitaba (ア ミ タ バ) extract * 4 0.5
(21) hops extract * 5 0.5
(22) peach extract * 6 0.5
(23) ethanol 5.0
(24) porous silica 3.0
(25) spice is an amount of
* agate (シ グ マ) society's system is consolidated in 1 west
* 2 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* 3BIO-DELL social system (Sen Shizuku)
* 4 balls are apt to pharmacy society system
* 5 balls are apt to pharmacy society system
* 6 balls are apt to pharmacy society system
(method for making)
A. heat blending constituent (13)～(22), remain on 70 ℃.
B. heat blending constituent (1)～(12), remain on 70 ℃.
C. in A, add B, uniformly emulsify.
After the D.C cooling, in C, add composition (23), (24), (25) mixing, and obtain emulsion.
Embodiment 4-4 and embodiment 4-5 have smooth softish usability, are the emulsions that can obtain not have skin whitening such as pachylosis and skin obfuscation.
(embodiment 4-6: facial film)
(composition) (%)
(1) polyvinyl alcohol 13.0
(2) anhydrous silicic acid 0.5
(3) Polyethylene Glycol 0.5
(4) the oily * 1 0.2 of a thick wood (メ De ウ ホ-system) that goes out
(5) polyoxypropylene (10P.O.) glucosides 5.0
(6) glycerol 5.0
(7) Purified Water surplus
(8) tea extract * 2 1.0
(9) sweetbrier polyantha extract * 3 1.0
(10) Caffeine Anhydrous * 4 1.0
(11) birch resin * 5 5.0
(12) phosphoric acid-L-vitamin C (Ascorbyl) magnesium * 6 3.0
(13) Purified Water 10.0
(14) to oxybenzoic acid ethyl ester 0.1
(15) ethanol 13.0
(16) spice is an amount of
* 1 Japanese Safa Ku Tantuo (Japanese サ-Off ア Network タ Application ト) industrial society system
* 2 balls are apt to pharmacy society system
* 3 balls are apt to pharmacy society system
* 4 pure pharmaceutical industries society systems
* 5 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* purple (daylight ケ ミ カ Le ズ) society's system in 6 daylight Kai Mika lands
(method for making)
A. blending constituent (1)～(7) are heated to 70 ℃ of dissolvings.
B. mixed dissolution composition (8)～(13).
C. mixed dissolution composition (14)～(16).
D. in A, add B, mix postcooling, add C, mix, obtain facial film.
Embodiment 4-6 has the refrigerant sense and the tight sense of appropriateness, and the skin behind flush coat can obtain tension sense, is the facial film that can obtain not have skin whitening such as pachylosis and skin obfuscation.
(embodiment 4-7: vanishing cream)
(composition) (%)
(1) sesquialter oleic acid acid sorbitan ester 3.0
(2) the self-emulsifying type glyceryl monostearate 2.0
(3) aluminium stearate 0.5
(4) ceresine 5.0
(5) Squalene 10.0
(6) Liquid Paraffin 15.0
(7) vaseline 5.0
(8) titanium oxide 8.0
(9) clay 4.0
(10) coloring pigment is an amount of
(11) to oxybenzoic acid methyl ester 0.05
(12) propylene glycol 5.0
(13) Flos Lonicerae extract * 1 1.0
(14) Betula platyphylla Suk. extract * 2 1.0
(15) Aesculus hippocastanum extract * 3 1.0
(16) birch resin * 4 10.0
(17) Purified Water surplus
(18) spice is an amount of
* 1 Changgong society of spice society system
* 2 balls are apt to pharmacy society system
* 3 fragrant Rong Xing leaf society systems
* 4 Sapp (さ つ Bru) manufactured (Sen Shizuku)
(method for making)
A. heat blending constituent (1)～(11), remain on 70 ℃.
B. heat blending constituent (12)～(17), remain on 70 ℃.
C. in A, add B, carry out emulsifying.
After the D.C cooling, in C, add composition (18) and mix, and obtain vanishing cream.
(embodiment 4-8: foundation emulsion)
(composition) (%)
(1) aqueous agnolin 2.0
(2) Liquid Paraffin 5.0
(3) stearic acid 2.0
(4) spermol 1.0
(5) the self-emulsifying type glyceryl monostearate 1.0
(6) p-methoxycinnamic acid-(2-ethylhexyl) ester 8.0
(7) the 4-tert-butyl group-4 '-methoxy dibenzoyl methylmethane 2.0
(8) palmitic acid retinal * 1 0.2
(9) to oxybenzoic acid methyl ester 0.1
(10) glycerol 5.0
(11) triethanolamine 1.0
(12) carboxy methyl cellulose 0.2
(13) bentonite 0.5
(14) silver birch extracting solution * 2 5.0
(15) Purified Water surplus
(16) mannitol * 3 0.1
(17) birch resin * 4 5.0
(18) Germinatus Phragmitis extract * 5 0.5
(19) Radix Glycyrrhizae extract * 6 0.5
(20) titanium oxide 6.0
(21) particulate titanium dioxide 2.0
(22) particulate oxide zinc 5.0
(23) Muscovitum 2.0
(24) Talcum 4.0
(25) coloring pigment 4.0
(26) spice is an amount of
* (Japanese ロ シ ユ) the society's system of repairing is revealed by 1 Japan
* 2 balls are apt to pharmacy society system
* agate (シ グ マ) society's systems are consolidated in 3 west
* 4 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* 5 balls are apt to pharmacy society system
* 6 balls are apt to pharmacy society system
(method for making)
A. mixed dissolution composition (1)～(9).
B. in A, add composition (20)～(25), uniform mixing remains on 70 ℃.
C. uniform dissolution composition (10)～(19) remain on 70 ℃.
D. in C, add B, carry out emulsifying.
E. after cooling off D, adding ingredient (26) mixes, and obtains foundation emulsion.
Embodiment 4-7 and embodiment 4-8 have dense smooth usability, are to obtain the result that evenly whitens, and this external enwergy obtains not have the vanishing cream and the foundation emulsion of skin whitening such as pachylosis and skin obfuscation.
(embodiment 4-9: ultra light sun block lotion)
(composition) (%)
(1) polyoxy alkylidene modification organopolysiloxane 1.0
(2) dimethyl polysiloxane 5.0
(3) octamethylcy-clotetrasiloxane 20.0
(4) different n-nonanoic acid isotridecyl ester 5.0
(5) p-methoxycinnamic acid-(2-ethylhexyl) ester 5.0
(6) to oxybenzoic acid methyl ester 0.1
(7) polysiloxanes is handled particulate titanium dioxide 10.0
(8) polysiloxanes is handled particulate oxide zinc 10.0
(9) polyethylene powders 3.0
(10) trimethylsiloxy silicic acid 0.5
(11) dipropylene glycol 3.0
(12) ethanol 10.0
(13) birch resin * 1 10.0
(14) Sal 0.2
(15) Purified Water surplus
(16) beta-carotene * 2 0.01
(17) chamomile extract * 3 1.0
(18) small burnet extract * 4 1.0
(19) spice is an amount of
* 1 Sapp (さ つ Bru) manufactured (Sen Shizuku)
* agate (シ グ マ) society's systems are consolidated in 2 west
* 3 balls are apt to pharmacy society system
* 4 balls are apt to pharmacy society system
(method for making)
A. blending constituent (1)～(10) remain on 70 ℃.
B. blending constituent (11)～(15) remain on 70 ℃.
C. in A, add B, uniformly emulsify.
After the D.C cooling, in C, add composition (16)～(19) and mix and the acquisition ultra light sun block lotion.
Embodiment 4-9 has the smooth usability that is not clamminess, and is under ultraviolet, to protect skin, obtains not have the ultra light sun block lotion of skin whitening such as pachylosis and skin obfuscation simultaneously.
Claims (4)
1. birch resin is used for the profilaggrin of cosmetics or skin preparations for extenal use or the application that the fiber polymeric protein produces promoter as preparation.
2. birch resin is used for the application of the Envelope generation promoter of cosmetics or skin preparations for extenal use as preparation.
3. birch resin is used for the application of the cholesterol generation promoter of cosmetics or skin preparations for extenal use as preparation.
4. birch resin is used for the application of the cell vitalizing agent of cosmetics or skin preparations for extenal use as preparation.
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP038695/2006 | 2006-02-16 | ||
| JP2006038696A JP5068952B2 (en) | 2006-02-16 | 2006-02-16 | Involucrin production promoter |
| JP2006038695A JP2007217325A (en) | 2006-02-16 | 2006-02-16 | Promoter for production of profillagrin and/or fillagrin |
| JP038696/2006 | 2006-02-16 | ||
| JP2006047594A JP4938319B2 (en) | 2006-02-24 | 2006-02-24 | Cholesterol production promoter and skin external preparation containing the same |
| JP047594/2006 | 2006-02-24 | ||
| JP2006055906A JP4758252B2 (en) | 2006-03-02 | 2006-03-02 | Cell activator and skin external preparation containing the same |
| JP055906/2006 | 2006-03-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101023915A CN101023915A (en) | 2007-08-29 |
| CN101023915B true CN101023915B (en) | 2012-03-28 |
Family
ID=38494992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2007100799033A Active CN101023915B (en) | 2006-02-16 | 2007-02-16 | Pharmaceutical agent containing birch extract as an effective ingredient and its use |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP2007217325A (en) |
| CN (1) | CN101023915B (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4938319B2 (en) * | 2006-02-24 | 2012-05-23 | 株式会社コーセー | Cholesterol production promoter and skin external preparation containing the same |
| JP5068952B2 (en) * | 2006-02-16 | 2012-11-07 | 株式会社コーセー | Involucrin production promoter |
| JP4758252B2 (en) * | 2006-03-02 | 2011-08-24 | 株式会社コーセー | Cell activator and skin external preparation containing the same |
| JP5771123B2 (en) * | 2011-11-09 | 2015-08-26 | 株式会社 資生堂 | PROFILAGLIN C-TERMINAL DOMAIN SPECIFIC ANTIBODY AND USE THEREOF |
| EP2883548B1 (en) * | 2012-08-10 | 2019-01-02 | Shiseido Company Ltd. | Filaggrin gene expression promoter |
| JP6498867B2 (en) * | 2014-04-04 | 2019-04-10 | 共栄化学工業株式会社 | Moisturizing composition |
| WO2016199927A1 (en) * | 2015-06-12 | 2016-12-15 | 日産化学工業株式会社 | Calcium salt composition and filaggrin production promoter using same |
| JP7075177B2 (en) * | 2015-06-30 | 2022-05-25 | 株式会社コーセー | Cosmetics |
| CN105662940B (en) * | 2016-01-05 | 2018-05-18 | 深圳典立生物科技有限公司 | Active compound and preparation method thereof and its application in cosmetics or skin care item |
| CN107019660B (en) | 2017-04-27 | 2018-05-11 | 养生堂（上海）化妆品研发有限公司 | Moisture-keeping cosmetics composition |
| CN109431900A (en) * | 2018-12-06 | 2019-03-08 | 余金铸 | A kind of shower wet tissue and preparation method thereof |
| CN110731924B (en) * | 2019-07-30 | 2022-05-17 | 浙江养生堂天然药物研究所有限公司 | Enhanced anti-aging cosmetic compositions |
| CN111990559A (en) * | 2020-09-15 | 2020-11-27 | 石卫华 | Birch juice beverage and preparation method thereof |
| WO2022122167A1 (en) | 2020-12-11 | 2022-06-16 | Symrise Ag | Medicament for preventing or treating pathologic conditions of human skin (i) |
| CN113288849A (en) * | 2021-06-30 | 2021-08-24 | 范祖强 | Facial mask and preparation method and application thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09291013A (en) * | 1996-04-25 | 1997-11-11 | Sunstar Inc | Skin cosmetic material |
| JP3762913B2 (en) * | 2002-05-14 | 2006-04-05 | 憲司 中村 | Skin care sheet |
| JP2006131546A (en) * | 2004-11-05 | 2006-05-25 | Asahi Kasei Life & Living Corp | Bath agent containing tree sap of japanese white birch |
| JP5068952B2 (en) * | 2006-02-16 | 2012-11-07 | 株式会社コーセー | Involucrin production promoter |
-
2006
- 2006-02-16 JP JP2006038695A patent/JP2007217325A/en active Pending
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2007
- 2007-02-16 CN CN2007100799033A patent/CN101023915B/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 回清杰等.桦树液系列化妆品.日用化学工业 第4期.1990,(第4期),第55和51页. |
| 回清杰等.桦树液系列化妆品.日用化学工业 第4期.1990,(第4期),第55和51页. * |
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| CN101023915A (en) | 2007-08-29 |
| JP2007217325A (en) | 2007-08-30 |
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