CN101019923A - Anticancer medicine and its prepn - Google Patents

Abstract

The present invention discloses one kind of anticancer medicine and its preparation process. The anticancer medicine is suitable for treating various kinds of cancer and has obvious curative effect, no toxic side effect and low cost. It is prepared with seven kinds of Chinese medicinal materials, including tortoise plastron, gromwell, sappan wood, notoginseng, sophora flower bud, etc.

Description

A kind of anticarcinogen and preparation method thereof

Technical field

The present invention relates to a kind of anticarcinogen and preparation method thereof, belong to technical field of Chinese medicines.

Background technology

At present, the main means of western medical treatment cancer are operation, radiotherapy, chemotherapy etc., though to prolonging cancer patient's life, improving life quality, played certain effect, side effect is big, expense is high, curative effect is barely satisfactory.With the cancer of pancreas is example, and various countries' statistics five year survival rate only is 2%-10%.Domestic in recent years antineoplastic product emerges in an endless stream, but is adjuvant mostly, and does not appear in the newspapers as yet with treatment by Chinese herbs cancer product merely.Chinese medicine has 4,000 years history, and excavating, study, screen the Chinese medicine malignant tumor has wide future.Begun to pay attention to, screen the treatment by Chinese herbs malignant tumor abroad.So need to be resolved hurrily be a kind of curative effect of screening certainly, and have no side effect or the tcm product of the treatment cancer that toxic and side effects is very little.

Summary of the invention

The present invention is directed to the deficiency of existing treatment cancer method and Drug therapy, provide a kind of evident in efficacy, have no side effect, taking convenience, economic, be applicable to the oral drugs of all kinds of cancer patients.

Anticarcinogen of the present invention is made by following medical material:

Raw tortoise plastron, Radix Arnebiae (Radix Lithospermi), Lignum Sappan, Radix Notoginseng powder, the Flos Sophorae Immaturus, Alumen, Realgar.

When the present invention prepared, the shared weight portion of each medical material was preferably:

Raw tortoise plastron 12-30 part, Radix Arnebiae (Radix Lithospermi) 6-30 part, Lignum Sappan 6-20 part, Radix Notoginseng powder 3-15 part,

Flos Sophorae Immaturus 10-30 part, Alumen 3-12 part, Realgar 1-5 part.

When the present invention prepared, the shared weight portion of each medical material was preferably:

21 parts of raw tortoise plastrons, 18 parts of Radix Arnebiae (Radix Lithospermi)s, 13 parts of Lignum Sappans, 9 parts of Radix Notoginseng powder, 20 parts of the Flos Sophorae Immaturus,

8 parts of Alumens, 3 parts of Realgars.

According to above-mentioned prescription, available method medically commonly used is prepared into various preparations alleged on the pharmaceutics with it.Such as capsule, tablet, oral liquid or granule etc.

Optimal preparation method of the present invention is: raw tortoise plastron is pounded be broken into fritter, insert and fry to very hot sand pot, urgently needed ferrum chopsticks stirs, and fries to the very hot jaundice of Carapax et Plastrum Testudinis, and sieve removes sand, Carapax et Plastrum Testudinis is put into rapidly contained the vinegar container, treats that steam pulls out to the greatest extent;

Carapax et Plastrum Testudinis behind the processed with vinegar and Lignum Sappan, the Flos Sophorae Immaturus are put into extraction pot, extracting in water three times removes slag, and merges three times extracting solution, concentrate in the container, to dripping chopsticks Cheng Zhu, add Radix Notoginseng powder and stir evenly, take out, put the dry taking-up of drying baker, adding Alumen, Realgar powder stir even, promptly encapsulated, perhaps make tablet, oral liquid, granule etc. according to conventional method.

Salty, the Gan Erping of Carapax et Plastrum Testudinis in the medicament composing prescription of the present invention, nourishing YIN for suppressing the hyperactive YANG makes the high and level tone sun close, and health invigorating improves the anticancer cancer that presses down of human immunity; Radix Arnebiae (Radix Lithospermi) is sweet, salty, cold in nature, clearing away heat and cooling blood, detoxifcation, but salty softening the hard mass; Lignum Sappan, Radix Notoginseng promoting the circulation of blood removing blood stasis with potent drugs, eliminating stagnation with the gram tumor, gross tumor volume is dwindled, and Radix Notoginseng are good at blood stasis dispelling blood and only hemorrhage, the convergence tumor surface of diabrosis (ulcer cancerous protuberance); The Flos Sophorae Immaturus is bitter cool, heat-clearing and toxic substances removing; Alumen is sour and astringent and cold, and is slightly poisonous, and the treating the poisonous disease with poisonous drugs gram kills carcinoma; The arduous temperature of Realgar, poisonous, treating the poisonous disease with poisonous drugs is attacked cancerous protuberance extremely.All medicines close and associate with, gather nourishing YIN for suppressing the hyperactive YANG, strengthening vital QI to eliminate pathogenic factors altogether, heat-clearing and toxic substances removing, attack extremely carcinoma, have that benefiting QI and nourishing blood, replenishing essence are defended by force, hard masses softening and resolving, separate and poison the tumor function, be applicable to multiple malignant tumor, especially cancer of pancreas there is special curative effect, show as after the treatment in a short time subjective symptoms and obviously improve or disappear, carcinoma dwindles, and other malignant tumor are also had certain curative effect.Can alleviate cancer patient's misery, improve cancer patient's symptom, prolong its life-span, suppress tumor growth, dwindle gross tumor volume, so that make the cancerous protuberance complete obiteration.

The specific embodiment

	Raw tortoise plastron	Radix Arnebiae (Radix Lithospermi)	Lignum Sappan	Radix Notoginseng powder	The Flos Sophorae Immaturus	Alumen	Realgar
								Embodiment 1	12g	6g	6g	3g	10g	3g	1g
Embodiment 2	21g	18g	13g	9g	20g	8g	3g
								Embodiment 3	30g	30g	20g	15g	30g	12g	5g

Raw tortoise plastron is pounded and is broken into fritter in the general side, inserts and fries to very hot sand pot, and urgently needed ferrum chopsticks stirs, and fries to the very hot jaundice of Carapax et Plastrum Testudinis, and sieve removes sand, Carapax et Plastrum Testudinis is put into rapidly contained the vinegar container, treats that steam pulls out to the greatest extent.

Carapax et Plastrum Testudinis behind the processed with vinegar and Lignum Sappan, the Flos Sophorae Immaturus are put into extraction pot, extracting in water three times, remove slag, merge three times extracting solution, concentrate in the container, become pearl to add Radix Notoginseng powder to a chopsticks and stir evenly, take out, put the dry taking-up of drying baker, adding Alumen, Realgar powder (Realgar removes clean impurity) stir even, promptly encapsulated.

Clinical data

From in June, 1973 to 1993 year December, merely with the observation of the present invention's treatment and system all kinds of malignant tumor 200 examples, wherein cancer of pancreas 13 examples (12 routine CT scan diagnosis, 1 routine laparotomy exploration pathological diagnosis), cardia gastric cancer 80 examples (62 routine pathology and gastroscope diagnosis, 18 routine X angiographic diagnosis), the esophageal carcinoma 42 examples (20 routine X angiographic diagnosis, 8 routine pathological diagnosis), pulmonary carcinoma 28 examples (20 routine X angiographic diagnosis, 8 routine pathological diagnosis), other intestinal cancer, breast carcinoma, hepatocarcinoma, nasopharyngeal carcinoma, gastric cancer, thyroid carcinoma, ovarian cancer, carcinoma of tongue, cervical cancer, cerebroma, renal carcinoma, totally 37 examples such as carcinoma of parotid glands etc., all cases all be out-patient treatment in, diffusion transfer in late period patient wherein has a considerable amount of cases to accept for medical treatment under critically ill situation.This group case age minimum is 18 years old, is up to 82 years old, and most ages are between 45-66 year.

Therapeutic Method: every powder charge 0.3g, oral.Look per 6 hours clothes of state of an illness 2-4 grain.

Diagnosis and curative effect determinate standard

1, diagnostic criteria: with the foundation that is diagnosed as case observation of hospital above the provincial level; The diagnosis of observing case meets the diagnostic criteria of the several frequently seen malignant tumor of health ministry formulation.

2, alleviate criterion: alleviate (CR) (tumor all disappears, and observes continuously more than 4 years, does not have recurrence, and energy person of working as ordinary person) fully; Part is alleviated (PR) (tumor dwindles 〉=1/2, keep person more than 2 years); Stable (NR) (tumor dwindles＜and 1/2 or enlarge less than 1/4, person more than a year holds time); Progress (PD) (tumor enlarges more than 1/4 before the treatment).

This project is studied 200 routine all kinds of malignant tumor, according to curative effect determinate standard, and clinical complete remission 49 examples, finishing remission rate is 24.5%, always treats effective case 152 examples, and total effective rate is 76%, wherein cancer of pancreas is alleviated 4 examples fully, and complete remission rate is 30.7%, and effective percentage is 92.2%; Esophageal carcinoma clinical complete remission 15 examples, complete remission rate are 35.7%; Cardia and gastric cancer are alleviated 21 examples fully, and the clinical complete remission rate is 25%, and effective percentage is 72.5%, and the effective percentage of pulmonary carcinoma is 82.1%.(seeing Table 1).

Table 1: the catalog of all kinds of malignant tumor of Taiyi capsule for treating

Example is treated mark effect class	The statistics case load	Alleviate fully (CR)	Part is alleviated (PR)	Stable (NR)	Progress (PD)	Effective percentage (%)
							Cancer of pancreas	13	4	5	3	1	922
Cardia gastric cancer	80	22	12	24	22	72.5
							The esophageal carcinoma	42	15	3	10	14	66.7
Intestinal cancer	5	1	3	1		72
							Breast carcinoma	3		2	1
Pulmonary carcinoma	28	3	7	13	5	82.1
							Hepatocarcinoma	11	1	3	4	3
Nasopharyngeal carcinoma	2	1	1
							Osteocarcinoma	5		3	2
Thyroid carcinoma	2		2
							Carcinoma of tongue	1	1
Cervical cancer	2		1	1
							Cerebroma	2		1		1
Renal carcinoma	1			1
							Carcinoma of parotid gland	1			1
Ovarian cancer	2	1	1
							Add up to	200	49	44	59	48

Annotate: the judgement of listed case curative effect in the table, by " criterion of traditional Chinese medical herbal treatment malignant tumor ", go statistics from subjective symptom, objective determination, life span three aspects.

Model case:

1, Wang, the woman 42 years old, is diagnosed as in provincial certain hospital's scan report on March 4th, 1989 (CT number 18930): swollen thing companion retroperitoneal lymph node shifts behind (1) peritoneum.(2) swollen thing adhesion behind cancer of pancreas and the peritoneum, it is unclear to demarcate.(3) spleen enlargement.On May 2nd, 1989 went to a doctor.Nausea and vomiting can not be taken food, and the pain play is lain awake all night unbearably.Stomach can touch as hard as flint around big abdomen and umbilicus, ganoid swollen thing is a plurality of, and what push away does not move.Upper abdomen is taken back by the side rib, also can lay one's hand on and quality hard, fixing, inactive huge swollen thing, surface irregularity.Patient's croucs, all the swollen thing top diaphragm of sense and lose heart and be not able to breath is become thin, and is symptoms such as cachexia face, throw product of the present invention, take a turn for the better day by day, after 3 months, the epigastrium side of taking back also can be touched the swollen thing of 10cm * 10cm size, use intermittent use instead, about 6 months, the B ultrasonic check, swollen thing disappears.Existing patient is alive, can take part in the work as ordinary person, no any discomfort sensation.On January 3rd, 1994 disappeared in Hebei province hospital and certain CT of hospital check tumor.

2, Lee, woman, 68 years old, the patient is because of inappetence, and the nausea and vomiting moon is surplus, and whole body dyes symptoms such as Huang and goes into provincial certain hospital on April 28th, 1991, admission number: 159852, through B ultrasonic and CT examination, (CT number: 103340) be diagnosed as obstructive jaundice due to the head of pancreas ditch cancer.Be in hospital and left hospital in 16 days.The back also is a carcinoma of head of pancreas in the CT examination report diagnosis of peaceful hospital.Go to a doctor on May 25th, 1991.Soup does not advance, and vomits yellowish green misery, mucus shape material, symptom such as whole body is yellow as the Pericarpium Citri Reticulatae color, is unable to leave the bed, and is nauseating is thrown product of the present invention, take medicine 3 months surplus, all transference cures.The swollen thing of B ultrasonic check disappears, and is existing alive, and on April 2nd, 1994, in the CT of Ji Second Academy check, the head of pancreas tumor disappeared again.

3, go into business certain, the man, 63 years old, on April 11st, 1991, provincial certain hospital's pathological replacement was diagnosed as the adenocarcinoma of stomach pathological number: 42160.Go to a doctor on May 16th, 1991, symptom such as vomiting saliva sputum is acute frequently, can not take food, and eats then and feels bad in the stomach, and pain is violent, and is just black, through surplus with product of the present invention 3 months, all transference cures can be participated in labor in general, and the check tumor disappears, and is existing alive.

4, for certain, the man, 50 years old, on May 2nd, 1973, provincial certain hospital's gullet radiography was diagnosed as esophago mesomere cancer 5cm, after all be diagnosed as esophago mesomere cancer at provincial how tame examination in hospital again.Esophagus draws in the net, and pathological replacement is a scale cancer.Went to a doctor on June 14th, 1973, a small amount of liquid food of patient is told sticking saliva, and product of the present invention is thrown in the food play of choking, and it is light to choke day by day, month surplus check, and cancerous protuberance disappears, the esophagus no abnormality seen.Now alive, swallow no any discomfort sensation, can participate in housework.

Claims (7)

1, a kind of anticarcinogen is characterized in that it being to be made by following medical material:

Raw tortoise plastron, Radix Arnebiae (Radix Lithospermi), Lignum Sappan, Radix Notoginseng powder, the Flos Sophorae Immaturus, Alumen, Realgar.

2, anticarcinogen according to claim 1, wherein the shared weight portion of each medical material is:

Raw tortoise plastron 12-30 part, Radix Arnebiae (Radix Lithospermi) 6-30 part, Lignum Sappan 6-20 part, Radix Notoginseng powder 3-15 part, Flos Sophorae Immaturus 10-30 part, Alumen 3-12 part, Realgar 1-5 part.

3, anticarcinogen according to claim 2, wherein the shared weight portion of each medical material is:

21 parts of raw tortoise plastrons, 18 parts of Radix Arnebiae (Radix Lithospermi)s, 13 parts of Lignum Sappans, 9 parts of Radix Notoginseng powder, 20 parts of the Flos Sophorae Immaturus, 8 parts of Alumens, 3 parts of Realgars.

4,, it is characterized in that described medicine is various preparations alleged on the pharmaceutics according to claim 1,2 or 3 described anticarcinogens.

5,, it is characterized in that described preparation is capsule, tablet, oral liquid or granule according to the described anticarcinogen of claim 4.

6, a kind of preparation method of anticarcinogen is characterized in that:

The raw medicinal material consumption is as follows:

Raw tortoise plastron 12-30 part, Radix Arnebiae (Radix Lithospermi) 6-30 part, Lignum Sappan 6-20 part, Radix Notoginseng powder 3-15 part, Flos Sophorae Immaturus 10-30 part, Alumen 3-12 part, Realgar 1-5g part;

Preparation method: with raw tortoise plastron, insert in the sand pot of making popular, stir, fry to the Carapax et Plastrum Testudinis jaundice, sieve removes sand, Carapax et Plastrum Testudinis is put into rapidly contained the vinegar container, treats that steam pulls out to the greatest extent;

Carapax et Plastrum Testudinis behind the processed with vinegar and Lignum Sappan, the Flos Sophorae Immaturus are put into extraction pot, and extracting in water three times removes slag, and merges three times extracting solution, and is concentrated in the container, to dripping a chopsticks Cheng Zhu, adds Radix Notoginseng powder and stirs evenly, take out, and drying, adding Alumen, Realgar powder stir even.

7, preparation method according to claim 6 is characterized in that:

The raw medicinal material consumption is as follows:

21 parts of raw tortoise plastrons, 18 parts of Radix Arnebiae (Radix Lithospermi)s, 13 parts of Lignum Sappans, 9 parts of Radix Notoginseng powder, 20 parts of the Flos Sophorae Immaturus, 8 parts of Alumens, 3 parts of Realgars;

Preparation method: raw tortoise plastron pounded be broken into fritter, insert and fry to very hot sand pot, urgently needed ferrum chopsticks stirs, and fries to the very hot jaundice of Carapax et Plastrum Testudinis, and sieve removes sand, Carapax et Plastrum Testudinis is put into rapidly contained the vinegar container, treats that steam pulls out to the greatest extent;

Carapax et Plastrum Testudinis behind the processed with vinegar and Lignum Sappan, the Flos Sophorae Immaturus are put into extraction pot, extracting in water three times removes slag, and merges three times extracting solution, concentrate in the container, to dripping chopsticks Cheng Zhu, add Radix Notoginseng powder and stir evenly, take out, put the dry taking-up of drying baker, adding Alumen, Realgar powder stir even, promptly encapsulated, perhaps make tablet, oral liquid, granule etc. according to conventional method.