CN101012417A - Application of glucosamine in wine and beer containing glucosamine - Google Patents
Application of glucosamine in wine and beer containing glucosamine Download PDFInfo
- Publication number
- CN101012417A CN101012417A CN 200710079890 CN200710079890A CN101012417A CN 101012417 A CN101012417 A CN 101012417A CN 200710079890 CN200710079890 CN 200710079890 CN 200710079890 A CN200710079890 A CN 200710079890A CN 101012417 A CN101012417 A CN 101012417A
- Authority
- CN
- China
- Prior art keywords
- glucosamine
- beer
- wine
- health
- care
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000013405 beer Nutrition 0.000 title claims abstract description 57
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 title claims description 107
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 title claims description 107
- 229960002442 glucosamine Drugs 0.000 title claims description 107
- 235000014101 wine Nutrition 0.000 title claims description 42
- 230000035622 drinking Effects 0.000 claims abstract description 9
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 9
- 229920002674 hyaluronan Polymers 0.000 claims description 9
- 229960003160 hyaluronic acid Drugs 0.000 claims description 9
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 241000219095 Vitis Species 0.000 claims description 6
- 235000009754 Vitis X bourquina Nutrition 0.000 claims description 6
- 235000012333 Vitis X labruscana Nutrition 0.000 claims description 6
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 3
- 235000011201 Ginkgo Nutrition 0.000 claims description 2
- 244000194101 Ginkgo biloba Species 0.000 claims description 2
- 235000008100 Ginkgo biloba Nutrition 0.000 claims description 2
- 239000012467 final product Substances 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 150000003740 xylobioses Chemical class 0.000 claims description 2
- 230000035790 physiological processes and functions Effects 0.000 abstract description 4
- JCZPMGDSEAFWDY-SQOUGZDYSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanamide Chemical compound NC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO JCZPMGDSEAFWDY-SQOUGZDYSA-N 0.000 abstract 2
- 230000000694 effects Effects 0.000 description 15
- 210000003491 skin Anatomy 0.000 description 13
- 208000012659 Joint disease Diseases 0.000 description 11
- 230000036541 health Effects 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 235000020095 red wine Nutrition 0.000 description 7
- 238000003756 stirring Methods 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 239000008103 glucose Substances 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 206010034464 Periarthritis Diseases 0.000 description 5
- 150000002302 glucosamines Chemical class 0.000 description 5
- 238000001727 in vivo Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 238000005303 weighing Methods 0.000 description 5
- 230000001476 alcoholic effect Effects 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- MSWZFWKMSRAUBD-GQNBSWLHSA-N (2s,5r)-3-amino-6-(hydroxymethyl)oxane-2,4,5-triol Chemical compound NC1[C@@H](O)OC(CO)[C@H](O)C1O MSWZFWKMSRAUBD-GQNBSWLHSA-N 0.000 description 3
- 208000006820 Arthralgia Diseases 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 3
- 241000905957 Channa melasoma Species 0.000 description 3
- 235000011089 carbon dioxide Nutrition 0.000 description 3
- 210000000845 cartilage Anatomy 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 238000011835 investigation Methods 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 230000002194 synthesizing effect Effects 0.000 description 3
- 229920002683 Glycosaminoglycan Polymers 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000008414 cartilage metabolism Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 229950006780 n-acetylglucosamine Drugs 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000009790 rate-determining step (RDS) Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical group S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- UBDZFAGVPPMTIT-UHFFFAOYSA-N 2-aminoguanidine;hydron;chloride Chemical compound [Cl-].NC(N)=N[NH3+] UBDZFAGVPPMTIT-UHFFFAOYSA-N 0.000 description 1
- 208000008822 Ankylosis Diseases 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- 240000004859 Gamochaeta purpurea Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010023198 Joint ankylosis Diseases 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 102000003960 Ligases Human genes 0.000 description 1
- 108090000364 Ligases Proteins 0.000 description 1
- 208000002720 Malnutrition Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 206010057178 Osteoarthropathies Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 206010039361 Sacroiliitis Diseases 0.000 description 1
- 101710167605 Spike glycoprotein Proteins 0.000 description 1
- LPQOADBMXVRBNX-UHFFFAOYSA-N ac1ldcw0 Chemical compound Cl.C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 LPQOADBMXVRBNX-UHFFFAOYSA-N 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 230000002917 arthritic effect Effects 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 210000001188 articular cartilage Anatomy 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 235000019606 astringent taste Nutrition 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000003570 biosynthesizing effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 150000002016 disaccharides Chemical group 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- YLRFCQOZQXIBAB-RBZZARIASA-N fluoxymesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)C[C@@H]2O YLRFCQOZQXIBAB-RBZZARIASA-N 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 235000015096 spirit Nutrition 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a hygienic beer with aminoglucose, which is characterized by the following: developing the physiological function of aminoglucose at drinking time; improving the function of articulation; accelerating articulation to recover.
Description
Technical field
The present invention relates to the health food technology field, be to be the health-care components of wine, and a kind of health-care beer that contains glucosamine is provided with the glucosamine.
The used glucosamine of the present invention is meant the glucosamine and the salt thereof in any existence form, any source.Wherein, glucosamine salt is sulfuric acid glucosamine, aminoguanidine hydrochloride glucose and hydrargyrum amidochloratum glucose.
Background technology
Spirits culture extensive knowledge and profound scholarship, of long standing and well established, in the wine cups and mora chips lying about in disorder--a hilarious party, people have not only enjoyed the pure and sweet of wine, have also enjoyed cultural fragrance.Wine makes human having a varicolored life, and becomes indispensable " lubricant " in official activity and private the entertaining.Drinking has double influence to body, and excessive consumption of alcohol is totally unfavorable to human body, and the space structure of understanding lipid in the cell membrane because of the ethanol in the wine impacts, and causes the damage of respective organization, malnutrition, even threat to life.But drink when an amount of, then can alleviate anxiety, stimulate circulation, relax the muscles and stimulate the blood circulation, some diseases is had certain prophylactic effect, as in the north of weather cold, the people of the outwork of being everlasting prevent all kinds of joint diseases by drinking (medicine) wine.Along with the raising of people's living standard, the wine with nourishing function is favored gradually, and especially Chinese medicine health-care wine is widely used in China.At present, the medicinal liquor kind of joint disease such as treatment of arthritis, scapulohumeral periarthritis is more, as disclosing a kind of in the patent documentation of ZL01113968.4 is the medicinal liquor of health-care components with the Viartril-S, but it is by the complicated operation of the low molecule Viartril-S of oxidation degradation method preparation, and the assimilation effect of low molecule Viartril-S is poor, has influenced it and has applied.
Glucosamine is one of constituent of organism, extensively is present in the tissues such as cartilage, tendon and ligament of humans and animals.Do not contain glucosamine in the food, therefore must rely in the organism synthetic.The ability of human body synthesizing amino glucose finally can cause all kinds of joint diseases such as sacroiliitis, scapulohumeral periarthritis worse and worse but with advancing age.
In addition, glucosamine also is the joint cartilage biosynthesizing and stimulates synthetic chitosan and hyaluronic precursor substance.Hyaluronic acid is the mucopolysaccharide that alternately is formed by connecting by glucuronic acid and N-n acetylglucosamine n disaccharide unit, extensively is present in each tissue of human body, and especially content is big in skin, cartilage and knuckle synovia.Hyaluronic acid has water conservation in vivo, removes physiological functions such as active oxygen radical.But hyaluronic turnover rate is but high highlightedly in Mammals, with age or be subjected to other physiology and Effect of Environmental, hyaluronic acid self can be degraded, cause each tissue, especially hyaluronic acid obviously reduces in skin, so can make the elasticity variation of skin and tiny wrinkle occur.In vivo, glucose and glutamine be synthesizing amino glucose under the effect of glucosmine synthetase, and glucosamine is generated the N-n acetylglucosamine n by further acetylize, and the latter forms one of hyaluronic monose.In the hyaluronic in vivo building-up process, generating glucosamine by glucose is a rate-limiting step, therefore directly give the energy battier that glucosamine can be crossed this rate-limiting step, improve hyaluronic resultant quantity, satisfy body and keep normal physiological function hyaluronic demand.
Glucosamine has obtained people's approval to the curative effect of joint disease.In addition, we find also that in test oral glucosamine has cosmetic result (CN1698626).At present, the protective foods that contains glucosamine has proposed multiple scheme, but yet there are no the health promoting wine that contains glucosamine.Therefore, invention is a health-care components with the glucosamine, has the health care drinks that prevents and treat all kinds of joint disease functions, is highly significant.
Summary of the invention
An object of the present invention is to propose glucosamine as the application of health-care components in all kinds of wine, wherein wine comprises beer, grape wine or liquor, preferably beer or grape wine, first-selected beer.The content of glucosamine in above-mentioned wine is 0.08g/L～100g/L, preferred 0.4g/L～10.0g/L, first-selected 0.8g/L～5.0g/L.
The application method of glucosamine in wine is: (1) joined glucosamine in the wine liquid before the production of wine enters the can operation and gets final product.(2) glucosamine is encased in the small package packaging container, before drinking, joins in the wine by human consumer oneself.It is the health-care beer of health-care components with the glucosamine that another object of the present invention provides a kind of.The content of glucosamine in above-mentioned beer is 0.08g/L～100g/L, preferred 0.4g/L～10.0g/L, first-selected 0.8g/L～5.0g/L.Except that containing glucosamine, also contain other compositions in the above-mentioned beer, wherein other compositions are selected from but are not limited to conventional beer composition and/or other health-care components, and other health-care components are selected from but are not limited to hyaluronic acid, xylo-bioses and/or Folium Ginkgo extract etc.
Health-care components of the present invention is a glucosamine.Glucosamine mainly shows as the health-care effect of body: (1) is improved function of joint and promoted the rehabilitation of joint disease: glucosamine is participated in the metabolism and the growth of articular cartilage tissue directly, can also promote the synthetic of the interior mucopolysaccharide of body, improve the stickiness of joint lubrication liquid, thereby symptoms such as the arthroncus that prevention and reduction osteoarthritis, rheumatic arthritis cause, ankylosis improve all kinds of arthritics' quality of life.(2) promote hyaluronic synthesizing: the glucosamine good biocompatibility, can be absorbed rapidly by body, participate in hyaluronic synthetic in vivo, thereby improve the water retention property of skin, the formation of the coarse and tiny wrinkle of prevention skin, keep the elasticity of skin, delaying decrepitude of skin shows as the cosmetic result of whole body.
Glucosamine is an ideal drinks health-care components, can be used for producing the health promoting wine with application prospect.We find that by test the content of glucosamine in beer is in 0.8g/L～5.0g/L scope, to improving function of joint and beauty treatment effect is preferably arranged.And its production method is easy, is convenient to use and promote.
Advantage of the present invention is: the relative molecular mass of (1) glucosamine is little, and good biocompatibility is absorbed its physiological function of back performance rapidly by body.(2) absorbed back synthetic hyaluronic acid under the effect of enzyme rapidly by body.The synthetic hyaluronic acid can act on intercellular substance and reticular tissue, and effect such as play moisturizing, preserve moisture, lubricate improves the living environment of cell, improves skin-nourishing, makes skin remain suitable humidity and good elasticity.(3) improve function of joint and promote the rehabilitation of joint disease effectively: glucosamine can promote the synthetic of chondrocyte's glycoprotein, improves the viscosity of knuckle synovia, improves the joint cartilage metabolism, the formation of accelerated bone cell, thus help the rehabilitation of osteoarthropathy.(4) glucosamine no impurity taste, viscosity is low, joins that the taste to wine has no adverse effects in the wine.For grape wine, can reduce astringent taste after the interpolation glucosamine.(5) health-care effect with glucosamine combines with the effect that an amount of ethanol accelerate blood circulates, relaxes the muscles and stimulate the blood circulation, and makes this health promoting wine have effects such as easypro the meridian dredging, wind-expelling pain-stopping.(6) satisfied the consumers demand of people to drinks nutrient laden and health careization.
The embodiment of the invention
Application and a kind of health-care beer of embodiment 1 glucosamine in beer
At first, preparation glucosamine solution: the powdery glucosamine of weighing 50.0g, under whipped state, glucosamine is joined in the 25.0L room temperature water gradually, be made into uniform glucosamine solution.
Secondly, by the pure mellow wine that has now after process for beer production prepares fermentation, before beer production is about to enter the can operation, in the pure mellow wine filter pipe, above-mentioned glucosamine solution is evenly added in the beer of 600L with adding volume pump.Storage wine jar needs carbonic acid gas to be equipped with pressure, stirs 3min, so that glucosamine homodisperse in beer.
At last, can, sterilization, decals, coding, vanning, making glucosamine content is the glucosamine health-care beer product of some specifications of 0.08g/L.
Application and a kind of health-care beer of embodiment 2 glucosamines in beer
At first, preparation glucosamine solution: the powdery glucosamine of weighing 625 g, under whipped state, glucosamine is joined in the 25.0L room temperature water gradually, be made into uniform glucosamine solution.
Secondly, by the pure mellow wine that has now after process for beer production prepares fermentation, before beer production is about to enter the can operation, in the pure mellow wine filter pipe, above-mentioned glucosamine solution is evenly added in the beer of 600L with adding volume pump.Storage wine jar needs carbonic acid gas to be equipped with pressure, stirs 3min, so that glucosamine homodisperse in beer.
At last, can, sterilization, decals, coding, vanning, making glucosamine content is the glucosamine health-care beer product of some specifications of 1.0g/L.
Application and a kind of health-care beer of embodiment 3 glucosamines in beer
At first, preparation glucosamine solution: the powdery glucosamine of weighing 3125g, under whipped state, glucosamine is joined in the 25.0L room temperature water gradually, be made into uniform glucosamine solution.
Secondly, by the pure mellow wine that has now after process for beer production prepares fermentation, before beer production is about to enter the can operation, in the pure mellow wine filter pipe, above-mentioned glucosamine solution is evenly added in the beer of 600L with adding volume pump.Storage wine jar needs carbonic acid gas to be equipped with pressure, stirs 3min, so that glucosamine homodisperse in beer.
At last, can, sterilization, decals, coding, vanning, making glucosamine content is the glucosamine health-care beer product of some specifications of 5.0g/L.
Application and a kind of health care red wine of embodiment 4 glucosamines in grape wine
Buying commercially available alcoholic strength is 12% (V/V) red wine 50.0L, produces glucosamine health care red wine of the present invention.
At first, preparation glucosamine solution: the powdery glucosamine of weighing 50.5g, under whipped state, glucosamine is joined in the 0.5L room temperature water gradually, be made into uniform glucosamine solution.
Secondly, stir on the limit, and the limit evenly is poured into above-mentioned glucosamine solution in the red wine of 50L.Stir 10min, so that glucosamine homodisperse in red wine.Make the glucosamine health care red wine 50.5L that alcoholic strength is about 12% (V/V).
At last, can, decals, making glucosamine content is the glucosamine health care red wine product of some specifications of 1.0g/L.
Application and a kind of health-care spirit of embodiment 5 glucosamines in liquor
Buying commercially available alcoholic strength is 39% (V/V) liquor 100L, produces glucosamine health-care spirit of the present invention.
At first, preparation glucosamine solution: the powdery glucosamine of weighing 102.5g, under whipped state, glucosamine is joined in the 2.5L room temperature water gradually, be made into uniform glucosamine solution.
Secondly, stir on the limit, and the limit evenly is poured into above-mentioned glucosamine solution in the liquor of 100L.Stir 5min, so that glucosamine homodisperse in liquor.Making alcoholic strength is the glucosamine health-care spirit 102.5L of 38% (V/V).
At last, can, decals, making glucosamine content is the glucosamine health-care spirit product of some specifications of 1.0g/L.
Experimental study data of the present invention
Investigation project 1: the present invention's glucosamine health-care beer is to improving the investigation of function of joint
Carry out test drunk by people.Method: select 88 examples to have people's glucosamine health-care beer on probation of different joint diseases (to adopt the glucosamine health-care beer of the embodiment of the invention 3, wherein the content of glucosamine is 5.0g/L), wherein gonalgia 32 people, articulations digitorum manus swelling 29 people, scapulohumeral periarthritis 27 people.Drink 300ml everyone every day, drank continuously 60 days, duration of test stops all pharmacological agenies.After drinking off-test, the description of self joint disease doing well,improving situation is put in order, the results are shown in Table 1 according to the individual.
Table 1 glucosamine health-care beer is drunk test-results (improvement to joint disease is investigated)
| Symptom | The test number | Recovery from illness | Produce effects | Take a turn for the better | Invalid |
| Gonalgia articulations digitorum manus swelling scapulohumeral periarthritis | 32 29 27 | 3 5 3 | 25 21 20 | 3 3 2 | 1 0 2 |
As known from Table 1, the health-care beer of the present invention that contains glucosamine has the effect of improving gonalgia, articulations digitorum manus swelling and scapulohumeral periarthritis, and improvement rate always is followed successively by 96.8%, 100% and 92.6%.This is that mainly glucosamine can improve the viscosity of knuckle synovia, improves the joint cartilage metabolism, thereby shows the rehabilitation that promotes joint disease and improve function of joint.But, owing to the degree difference of the state of an illness,, can fully recover, and,, also need the bound drug treatment though symptom take a favorable turn for the heavier people of the state of an illness by drinking the glucosamine health-care beer for the lighter people of illness.
Investigation project 2: the cosmetic result of the present invention's glucosamine health-care beer (to the influence of moisture content of skin)
Method: choose healthy male 62 people and carry out test drunk by people, be divided into 2 groups at random, every group 31 people.The A group is drunk ordinary beer, in contrast group; The B group is drunk glucosamine health-care beer (adopt the glucosamine health-care beer of the embodiment of the invention 2, wherein the content of glucosamine is 1.0g/L).Drink 300ml everyone every day, drink 35d continuously.Drinking preceding first and drinking 36 couples of each group personnel of d and carry out the skin moisture assay, the results are shown in Table 2.
The comparison of moisture content of skin before and after each group of table 2 is tried out (
)
| Group | Number | Before the test-meal | After the test-meal |
| Ordinary beer group glucosamine beer group | 31 31 | 10.51±1.92 10.39±1.87 | 10.59±2.17 13.89±2.99 a，b |
Annotate: with take preceding comparison on the same group,
aThere is significant difference P＜0.01; Compare with the ordinary beer group,
bThere is significant difference P＜0.01
As shown in Table 2, the present invention's glucosamine beer is after trying out, and the water content of skin improves, with try out on the same group before and control group compare that there was a significant difference (P＜0.01).This mainly is health-care components of the present invention---the good absorbing effect of glucosamine, can synthesize hyaluronic acid in vivo, and can increase the hyaluronic content of endogenous by corium to epidermis, improve the water retention property of skin, show the ideal cosmetic result.
Claims (10)
1. glucosamine is as the application of health-care components in wine, and wherein wine comprises beer, grape wine or liquor, preferably beer or grape wine, first-selected beer.
2. the glucosamine of claim 1 indication is meant the glucosamine and the salt thereof in any existence form, any source.
3. the described application of claim 1 is characterized in that, the content of glucosamine in wine is 0.08g/L～100g/L, preferred 0.4g/L～10.0g/L, first-selected 0.8g/L～5.0g/L.
4. the described application of claim 1 is characterized in that, glucosamine is joined in the wine liquid get final product before the production of wine enters the can operation.
5. the described application of claim 1 is characterized in that, glucosamine is encased in the small package packaging container, is joined in the wine before drinking by human consumer oneself.
6. a health-care beer is characterized in that containing glucosamine.
7. a beer as claimed in claim 6 is characterized in that, the content of glucosamine in beer is 0.08g/L～100g/L, preferred 0.4g/L～10.0g/L, first-selected 0.8g/L～5.0g/L.
8. a beer as claimed in claim 6 is characterized in that, also contains other compositions.
9. a beer as claimed in claim 8 is characterized in that, other compositions are selected from but are not limited to conventional beer composition and/or other health-care components.
10. a beer as claimed in claim 9 is characterized in that, other health-care components are selected from but are not limited to hyaluronic acid, xylo-bioses and/or Folium Ginkgo extract.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200710079890 CN101012417A (en) | 2007-02-16 | 2007-02-16 | Application of glucosamine in wine and beer containing glucosamine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200710079890 CN101012417A (en) | 2007-02-16 | 2007-02-16 | Application of glucosamine in wine and beer containing glucosamine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101012417A true CN101012417A (en) | 2007-08-08 |
Family
ID=38700146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200710079890 Pending CN101012417A (en) | 2007-02-16 | 2007-02-16 | Application of glucosamine in wine and beer containing glucosamine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101012417A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112375633A (en) * | 2020-11-26 | 2021-02-19 | 江苏双林海洋生物药业有限公司 | Glucosamine wine and preparation method thereof |
-
2007
- 2007-02-16 CN CN 200710079890 patent/CN101012417A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112375633A (en) * | 2020-11-26 | 2021-02-19 | 江苏双林海洋生物药业有限公司 | Glucosamine wine and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102150836B (en) | Ammonia sugar peptide soft capsule | |
| CN102266274B (en) | Agent for enhancing collagen production and uses thereof | |
| JP2001048789A (en) | Agent for beautifying skin and health and beauty food | |
| CN105792837A (en) | Compositions comprising collagen peptides, elastin peptides and proteoglycans | |
| CN102423487B (en) | Osteoarticular health-care composition and its application | |
| CN101012419A (en) | Application of hyaluronic acid in wine and beer containing hyaluronic acid | |
| CN101766635B (en) | Composite for disintoxicating and sobering | |
| CN101049157B (en) | Functional health food for preventing osteoporosis | |
| CN101912132A (en) | Collagen beverage and preparation method thereof | |
| CN104164345B (en) | Be rich in the preparation method of the functional sorosis fermented wine of ferment | |
| JPWO2006070453A1 (en) | Healthy drink | |
| CN114938835A (en) | Dihydroquercetin SOD (superoxide dismutase) collagen tripeptide beverage formula | |
| JP3899436B2 (en) | Healthy drink with water soluble nucleoprotein | |
| CN109123622A (en) | A kind of conditioning health rose fermentation ferment and preparation method thereof | |
| CN109907191A (en) | A kind of Rosa roxburghii Tratt ferment drink and preparation method thereof | |
| CN102379391A (en) | Preparation of health food of pine pollen, glucan and natto | |
| CN104430179A (en) | Method for breeding piglet | |
| CN101538519A (en) | Pure-natural double-worm health-care rice wine and preparation method thereof | |
| CN101012417A (en) | Application of glucosamine in wine and beer containing glucosamine | |
| CN102715606A (en) | Beverage | |
| KR20010097872A (en) | Sports beverage composition and method thereof | |
| Chon et al. | Physiochemical and organoleptic properties of kefir containing different concentrations of hyaluronic acid: A preliminary study | |
| CN105176773A (en) | Pumpkin wine capable of adjusting blood glucose and making method thereof | |
| CN101983721B (en) | Desert cistanche calcium composition having functions of fatigue resistance and calcium supplement | |
| CN104026589A (en) | Peptide phenoloxidase as well as preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Open date: 20070808 |