CN101011437A - Traditional Chinese medicine achyranthes extract and preparation method and use thereof - Google Patents
Traditional Chinese medicine achyranthes extract and preparation method and use thereof Download PDFInfo
- Publication number
- CN101011437A CN101011437A CNA2007100197804A CN200710019780A CN101011437A CN 101011437 A CN101011437 A CN 101011437A CN A2007100197804 A CNA2007100197804 A CN A2007100197804A CN 200710019780 A CN200710019780 A CN 200710019780A CN 101011437 A CN101011437 A CN 101011437A
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- extract
- radix achyranthis
- achyranthis bidentatae
- chinese medicine
- preparation
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Abstract
The invention relates to a method for preparing achyranthes extractive, which comprises that using 0-95% alcohol solution to extract the achyranthes for 1-3 times, combining the extractives, using gel post chromatography to separate and purify, freezing and drying the eluent, to obtain the product, which can be used to prepare the drug for treating cerebral apoplexy, optic nerve hurt or the like. The invention has high safety, significant drug effect, and wide application.
Description
Technical field:
The present invention relates to extract, extracting method and the purposes of material in a kind of natural plants.
Background technology:
Development along with modern society, factors such as vehicle accident, war, natural disaster, aged tendency of population, make that the incidence rate of nerve injury and nervous system retrograde affection is in rising trend, seeking the active drug that promotes injured nerve reparation, prevention and treatment nervous system degeneration, is problem noticeable in the current medical research.
Chinese medicine is the great treasure-house of motherland's medicine and pharmacology, has determined curative effect, advantage that toxic and side effects is little, not only is subjected to the attention that domestic the world of medicine also is subjected to world colleague, and it is truly having the extensive prospect of development and use.Treatment by Chinese herbs nerve injury, neurodegenerative diseases are long-pending many experiences, and more clinical report is arranged, and also extracts the effective ingredient with neurotrophic effect in recent years in succession from natural plants.But can effectively promote nerve growth clinically so far, prevent that the new Chinese medicine of neurodegeneration is actually rare, still can not satisfy the needs of clinical patients.
Radix Achyranthis Bidentatae is an amaranthaceous plant, medicinal its dry root.Radix Achyranthis Bidentatae contains Saponin, polysaccharide, glycopeptide, sterol, sterone, alkaloid, coumarin etc.Radix Achyranthis Bidentatae has invigorating the liver and kidney, bone and muscle strengthening, and eliminating blood stasis and inducing menstruation, the effect of conducting blood to flow downwards, available soreness of waist and knee joint, muscles and bones are unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG etc.
Summary of the invention:
The object of the present invention is to provide a kind of Chinese medicine Radix Achyranthis Bidentatae extract that from Radix Achyranthis Bidentatae, extracts and preparation method and purposes.
Technical solution of the present invention is:
A kind of Chinese medicine Radix Achyranthis Bidentatae extract is characterized in that: adopt following method to obtain: with single medical material Radix Achyranthis Bidentatae decoction pieces, extract 1～3 time with 0～95% ethanol water, and merge extractive liquid,, through the gel filtration chromatography separation and purification, eluent gets product through lyophilization.The product main component is sterol ketone, polysaccharide etc.
A kind of preparation method of Chinese medicine Radix Achyranthis Bidentatae extract is characterized in that: comprise the following steps: single medical material Radix Achyranthis Bidentatae decoction pieces, extract 1～3 time with 0～95% ethanol water, merge extractive liquid,, through the gel filtration chromatography separation and purification, eluent gets product through lyophilization.
A kind of Chinese medicine Radix Achyranthis Bidentatae extract is in the medicine of nerve injury diseases such as preparation defying age, control nerve retrograde affection and treatment apoplexy, optic nerve injury, spinal cord injury, peripheral nerve injury and the application in the health product.
Extract of the present invention has the nerve growth of promotion, prevents the Neuron Apoptosis effect, its crude drug source is single, preparation method advanced person, technology is reasonable, the preparation definite ingredients, safe, pharmacological action is remarkable, can be used for preparing the medicine and the health product of nerve injury diseases such as defying age, control nerve retrograde affection and treatment apoplexy, optic nerve injury, spinal cord injury, peripheral nerve injury.
The invention will be further described below in conjunction with embodiment.
The specific embodiment:
Embodiment 1: the preparation of Radix Achyranthis Bidentatae extract A and effect
Get the Radix Achyranthis Bidentatae decoction pieces, be soaked in water 1 hour, use respectively under 80 ℃ of temperature of 10,8,6 times of water gagings (or 10 ℃, 50 ℃) condition and extract secondary, each 1 hour, merge extractive liquid, is through gel column (Sephadex-G50) chromatography purification, water eluting, eluent is through-30～-50 ℃ of lyophilizations, and packing promptly gets product A.The main component of A is sterone, polysaccharide etc., has the effect that promotes nerve growth, prevents Neuron Apoptosis in vivo and in vitro.Can be used for preparing the medicine and the health product of nerve injury diseases such as defying age, control nerve retrograde affection and treatment apoplexy, optic nerve injury, spinal cord injury, peripheral nerve injury.
Embodiment 2: the preparation of Radix Achyranthis Bidentatae extract B and effect
Get the Radix Achyranthis Bidentatae decoction pieces, measure 70% ethanol water heating and refluxing extraction three times with 8,6,4 times respectively, each 2 hours, merge extractive liquid,, decompression recycling ethanol.Extract is through gel column (Sephadex-G50) chromatography purification, the water eluting, and eluent is through-30～-50 ℃ of lyophilizations, and packing promptly gets product B.The main component of B is sterone, polysaccharide etc., has the effect that promotes nerve growth, prevents Neuron Apoptosis in vivo and in vitro.Can be used for preparing the medicine and the health product of nerve injury diseases such as defying age, control nerve retrograde affection and treatment apoplexy, optic nerve injury, spinal cord injury, peripheral nerve injury.
Embodiment 3: the preparation of Radix Achyranthis Bidentatae extract C and effect
Get the Radix Achyranthis Bidentatae decoction pieces, measure 95% ethanol water heating and refluxing extraction three times with 8,6,4 times respectively, each 2 hours, merge extractive liquid,, decompression recycling ethanol.Extract is through gel column (Sephadex-G50) chromatography purification, the water eluting, and eluent is through-30～-50 ℃ of lyophilizations, and packing promptly gets C.The main component of C is sterone, polysaccharide etc., have the effect that promotes nerve growth, prevents Neuron Apoptosis in vivo and in vitro, can be used for preparing the medicine and the health product of nerve injury diseases such as defying age, control nerve retrograde affection and treatment apoplexy, optic nerve injury, spinal cord injury, peripheral nerve injury.
Claims (3)
1, a kind of Chinese medicine Radix Achyranthis Bidentatae extract is characterized in that: adopt following method to obtain: with single medical material Radix Achyranthis Bidentatae decoction pieces, extract 1～3 time with 0～95% ethanol water, and merge extractive liquid,, through the gel filtration chromatography separation and purification, eluent gets product through lyophilization.
2, a kind of preparation method of Chinese medicine Radix Achyranthis Bidentatae extract is characterized in that: comprise the following steps: single medical material Radix Achyranthis Bidentatae decoction pieces, extract 1～3 time with 0～95% ethanol water, merge extractive liquid,, through the gel filtration chromatography separation and purification, eluent gets product through lyophilization.
3, a kind of Chinese medicine Radix Achyranthis Bidentatae extract is in the medicine of nerve injury diseases such as preparation defying age, control nerve retrograde affection and treatment apoplexy, optic nerve injury, spinal cord injury, peripheral nerve injury and the application in the health product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100197804A CN101011437A (en) | 2007-02-08 | 2007-02-08 | Traditional Chinese medicine achyranthes extract and preparation method and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2007100197804A CN101011437A (en) | 2007-02-08 | 2007-02-08 | Traditional Chinese medicine achyranthes extract and preparation method and use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101011437A true CN101011437A (en) | 2007-08-08 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2007100197804A Pending CN101011437A (en) | 2007-02-08 | 2007-02-08 | Traditional Chinese medicine achyranthes extract and preparation method and use thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN101011437A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009127130A1 (en) * | 2008-04-18 | 2009-10-22 | 南通大学 | Achyranthes bidentata polypeptide and production methods and uses thereof |
| CN111217894A (en) * | 2018-11-25 | 2020-06-02 | 中国科学院大连化学物理研究所 | Multi-disulfide long-chain peptide with neuroprotective activity, pharmaceutical composition and application |
-
2007
- 2007-02-08 CN CNA2007100197804A patent/CN101011437A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009127130A1 (en) * | 2008-04-18 | 2009-10-22 | 南通大学 | Achyranthes bidentata polypeptide and production methods and uses thereof |
| CN111217894A (en) * | 2018-11-25 | 2020-06-02 | 中国科学院大连化学物理研究所 | Multi-disulfide long-chain peptide with neuroprotective activity, pharmaceutical composition and application |
| CN111217894B (en) * | 2018-11-25 | 2022-05-31 | 中国科学院大连化学物理研究所 | Multi-disulfide long-chain peptide with neuroprotective activity, pharmaceutical composition and application |
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