CN101003550A - 8-卤代腺嘌呤类核苷化合物、合成方法和其药物用途 - Google Patents
8-卤代腺嘌呤类核苷化合物、合成方法和其药物用途 Download PDFInfo
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- CN101003550A CN101003550A CN 200610160030 CN200610160030A CN101003550A CN 101003550 A CN101003550 A CN 101003550A CN 200610160030 CN200610160030 CN 200610160030 CN 200610160030 A CN200610160030 A CN 200610160030A CN 101003550 A CN101003550 A CN 101003550A
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Abstract
Description
药物 | CC50(μg/ml) | EC50(μg/ml) | SI | ||
CPE | MTT | CPE | MTT | ||
TDF | 75.43±8.69 | 124.32±5.61 | 0.36±0.27 | 210± | 345± |
C-01 | 24.04±11.33 | 43.11±4.91 | 4.304±3.12 | 8.65±9.40 | 14.1±11.46 |
C-02 | 62.21±6.31 | >102.18±3.08 | 0.30±0.24 | 319.9±278.46 | >510.5±422.14 |
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CN200610160030A CN101003550B (zh) | 2006-12-30 | 2006-12-30 | 8-卤代腺嘌呤类核苷化合物、合成方法和其药物用途 |
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CN200610160030A CN101003550B (zh) | 2006-12-30 | 2006-12-30 | 8-卤代腺嘌呤类核苷化合物、合成方法和其药物用途 |
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CN101003550A true CN101003550A (zh) | 2007-07-25 |
CN101003550B CN101003550B (zh) | 2010-05-19 |
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CN200610160030A Active CN101003550B (zh) | 2006-12-30 | 2006-12-30 | 8-卤代腺嘌呤类核苷化合物、合成方法和其药物用途 |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103880884A (zh) * | 2014-03-21 | 2014-06-25 | 浙江苏泊尔制药有限公司 | 一种高纯度富马酸泰诺福韦酯的制备方法 |
WO2015143712A1 (en) * | 2014-03-28 | 2015-10-01 | Merck Sharp & Dohme Corp. | 4'-substituted nucleoside reverse transcriptase inhibitors |
US9908908B2 (en) | 2012-08-30 | 2018-03-06 | Jiangsu Hansoh Pharmaceutical Co., Ltd. | Tenofovir prodrug and pharmaceutical uses thereof |
US11040975B2 (en) | 2017-12-08 | 2021-06-22 | Merck Sharp & Dohme Corp. | Carbocyclic nucleoside reverse transcriptase inhibitors |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1465582A (zh) * | 2002-07-01 | 2004-01-07 | 中国人民解放军军事医学科学院放射医 | 核苷酸类似物、含它的药物组合物及其用途 |
CN1634943A (zh) * | 2004-11-05 | 2005-07-06 | 中国医学科学院医药生物技术研究所 | 一组非环核苷酸类似物及其合成方法和在抗病毒中的应用 |
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2006
- 2006-12-30 CN CN200610160030A patent/CN101003550B/zh active Active
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9908908B2 (en) | 2012-08-30 | 2018-03-06 | Jiangsu Hansoh Pharmaceutical Co., Ltd. | Tenofovir prodrug and pharmaceutical uses thereof |
CN103880884A (zh) * | 2014-03-21 | 2014-06-25 | 浙江苏泊尔制药有限公司 | 一种高纯度富马酸泰诺福韦酯的制备方法 |
WO2015143712A1 (en) * | 2014-03-28 | 2015-10-01 | Merck Sharp & Dohme Corp. | 4'-substituted nucleoside reverse transcriptase inhibitors |
US11040975B2 (en) | 2017-12-08 | 2021-06-22 | Merck Sharp & Dohme Corp. | Carbocyclic nucleoside reverse transcriptase inhibitors |
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Publication number | Publication date |
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CN101003550B (zh) | 2010-05-19 |
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Ausun Pharmatech. Co., Ltd. Assignor: Center of Analysis & Test, Henan Prov. Contract record no.: 2011330000341 Denomination of invention: Nucleotide compound in halogenating adenine class, synthetic method, medical appliction Granted publication date: 20100519 License type: Exclusive License Open date: 20070725 Record date: 20110425 |
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Owner name: ZHEJIANG AOXIANG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: CENTER OF ANALYSIS + TEST, HENAN PROV. Effective date: 20130521 |
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Free format text: CORRECT: ADDRESS; FROM: 450002 ZHENGZHOU, HENAN PROVINCE TO: 317016 TAIZHOU, ZHEJIANG PROVINCE |
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Effective date of registration: 20130521 Address after: 317016 Zhejiang chemical raw materials base in the East China Sea Park Road, No. fourth, No. 5 Patentee after: Zhejiang Ausun Pharmaceutical Co., Ltd. Address before: 450002 Henan city of Zhengzhou Province Red Road No. 56 Patentee before: Center of Analysis & Test, Henan Prov. |
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C56 | Change in the name or address of the patentee |
Owner name: ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME: ZHEJIANG AOXIANG PHARMACEUTICAL CO., LTD. |
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CP01 | Change in the name or title of a patent holder |
Address after: 317016 Zhejiang chemical raw materials base in the East China Sea Park Road, No. fourth, No. 5 Patentee after: Zhejiang Ao Xiang medicine company limited-liability company Address before: 317016 Zhejiang chemical raw materials base in the East China Sea Park Road, No. fourth, No. 5 Patentee before: Zhejiang Ausun Pharmaceutical Co., Ltd. |