CN101002810A - Dripping pills of schefflera arboricola, and its preparing method - Google Patents
Dripping pills of schefflera arboricola, and its preparing method Download PDFInfo
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- CN101002810A CN101002810A CN 200610049082 CN200610049082A CN101002810A CN 101002810 A CN101002810 A CN 101002810A CN 200610049082 CN200610049082 CN 200610049082 CN 200610049082 A CN200610049082 A CN 200610049082A CN 101002810 A CN101002810 A CN 101002810A
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Abstract
A dripping pill of scandent schefflera for treating pain, rheumatalgia, neuralgia, stomach-ache, bone fracture, injury, etc is prepared from scandent schefflera root. Its preparing process is also disclosed.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, particularly a kind of dripping pills of schefflera arboricola and preparation technology thereof.
Background technology
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) has another name called Rohdea japonica Roth, five pawl leaves.Be root or the stem and leaf of Araliaceae schefflera arboricola Schefflera arboricolaHagata, main product is in Yunnan.Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) has promoting blood circulation to remove blood stasis, alleviating pain and detumescence, relaxing muscles and tendons and activating QI and blood in the collateral, expelling wind and removing dampness effect.The leaf of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) commonly used among the people is mashed outsourcing treatment fracture and is swollen and ache and traumatic hemorrhage.Modern pharmacological research confirms that Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) has stronger analgesic activity, sedation, anticonvulsant action, also works the effect of alleviating pain by the obvious inhibition to smooth muscle contraction.Be applicable to the various pain of treatment, rheumatic arthralgia, neuralgia, stomachache, injury and bone fracture, traumatic hemorrhage.Determined curative effect, side effect is little.
The oral formulations of Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) is mainly tablet (the 11 of the Sanitation Ministry medicine standard Chinese patent medicine prescribed preparation, WS in the market
3-B-2073-96).Because the conventional tablet fabricating technology has, and makes this class oral formulations exist disintegration long, absorption difference, onset is slow, and bioavailability is lower, thereby influences giving full play to of drug effect.Between the storage life, be easy to simultaneously sliver, variable color, the moisture absorption etc., quality instability.Dripping pills of schefflera arboricola of the present invention has overcome the weak point of tablet, and it is little to have a taking dose, disintegrate is molten loose fast, the dissolution height, the bioavailability height, quality stability is good, release fast, the characteristics of produce effects fast, can sublingual administration, also can swallow, onset is faster than tablet, and is easy to carry and use.Preparation process of the present invention is simple, and workshop does not have dust, uses supplementary product kind few, and production process is short, steady quality, and cost is low.
Summary of the invention
The object of the invention provides a kind of pharmaceutical preparation-dripping pills of schefflera arboricola and preparation technology thereof.Dripping pills of schefflera arboricola of the present invention has expelling wind and removing dampness, and the function of promoting blood circulation and stopping pain is used for the treatment of various pain, rheumatic arthralgia, neuralgia, stomachache, injury and bone fracture, traumatic hemorrhage.
The invention is characterized in and adopt the Chinese crude drug Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) to make extract through extracting, extract and drop pill substrate is formulated.The weight ratio of each composition is:
Radix Schefflerae Arboricolae extract: drop pill substrate=1: 1～1: 5
The present invention can be achieved through the following technical solutions:
Get the Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) medical material, decoct with water secondary, amount of water is 8～10 times of amounts for the first time, be 6～8 times of amounts for the second time, decocting time 3 hours for the first time, 2 hours for the second time, collecting decoction, left standstill 12 hours, filter, filtrate is concentrated into the extractum of relative density 1.12～1.22 (60 ℃), adds ethanol and makes that to contain the alcohol amount be 50%～70%, stir, left standstill 12 hours, and got supernatant and reclaim ethanol, be concentrated into the extractum of relative density 1.15～1.25 (60 ℃), add ethanol again and make that to contain alcohol amount be 60%～80%, stir, left standstill 12 hours, get supernatant and reclaim ethanol, be condensed into extractum, extractum vacuum drying or spray drying are got extract.Get extract, pulverize, cross 100 mesh sieves.By weight being Radix Schefflerae Arboricolae extract: the ratio of drop pill substrate=1: 1～1: 5, join (80～85 ℃) in the fused drop pill substrate, stir, splash in dimethicone or other drop pill coolant (1～5 ℃), separate drop pill, absorb coolant, drying, promptly.
Utilize the drop pill of method preparation of the present invention, its main feature is:
1. the quick stripping of medicine, the dissolution height, rapid-action, the bioavailability height, side effect is little.Dripping pills of schefflera arboricola is to adopt solid dispersion technology, with mixing after medicine and the fusion of drop pill substrate, solidifies by system of dripping and quenching, makes medicine be molecule, colloid or microcrystalline state and is scattered in the substrate.Because the gross area of medicine increases, medicine disengages with crystallite or unformed microgranule, so medicine dissolution and absorption quickening, and bioavailability improves.
2. medicine stability is good.Dropping pill formulation by medicine and substrate heating and melting after, splash in the immiscible liquid coolant and make, reduce with the air contact area, be difficult for oxidation, substrate is non-water thing, is difficult for causing drug hydrolysis, stability of drug is increased, thereby guaranteed drug quality.
3. increased administering mode, dripping pills of schefflera arboricola both can be swallowed, but buccal again, and the patient of being convenient to dysphagia takes.As adopt the sublingual administration administration, and and after contacting, saliva dissolves rapidly, absorb by oral mucosa, directly enter blood circulation without gastrointestinal tract and liver, not only avoided the liver sausage first-pass effect, and it is rapid to have reached onset, improve bioavailability, reduce the purpose of side effect.
4. drop pill production technology, production equipment are simple, with short production cycle, the production efficiency height, and cost is low.
5. in the main production process of drop pill, used material all is to carry out under liquid state, has reduced dust pollution, helps labor protection and environmental protection, helps the GMP management.
The specific embodiment
Further the present invention can be described by the following examples, but not limited by embodiment.
Embodiment one: get Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) leaf 3000g, decoct with water secondary, amount of water is 8 times of amounts for the first time, be 6 times of amounts for the second time, decocting time 3 hours for the first time, 2 hours for the second time, collecting decoction, left standstill 12 hours, filter, filtrate is concentrated into the extractum of relative density 1.12～1.22 (60 ℃), adds ethanol and makes that to contain the alcohol amount be 60%, stir, left standstill 12 hours, and got supernatant and reclaim ethanol, be concentrated into the extractum of relative density 1.15～1.25 (60 ℃), add ethanol again and make that to contain alcohol amount be 70%, stir, left standstill 12 hours, get supernatant and reclaim ethanol, be condensed into extractum, the extractum vacuum drying is got extract.Get extract, pulverize, cross 100 mesh sieves.It is Radix Schefflerae Arboricolae extract by weight: Polyethylene Glycol
6000=1: 2 ratio joins in the molten matrix (80 ℃), stirs, and splashes into (2 ℃) in the dimethyl-silicon oil coolant, separates drop pill, absorbs coolant, drying, promptly.
Embodiment two: get the extract of embodiment one, pulverize, cross 100 mesh sieves.By weight for Radix Schefflerae Arboricolae extract: (mixed-matrix is a Polyethylene Glycol to the ratio of mixed-matrix=1: 1.5
6000: poloxamer is pressed 1: 0.3 prescription), join (82 ℃) in the fused mixed-matrix, stir, splash into (3 ℃) in the dimethyl-silicon oil coolant, separate drop pill, absorb coolant, drying, promptly.
Embodiment three: present embodiment is by Radix Schefflerae Arboricolae extract and different substrates prescription, investigates indexs such as roundness, the ball method of double differences are different, hardness, molten diffusing time, to determine the weight ratio of extract and single or mixed-matrix.
Radix Schefflerae Arboricolae extract and different substrates formula test (extract is 1 part)
Annotate: 1. coolant is dimethicone or liquid paraffin, and chilling temperature is 1～5 ℃; Spice insulation and water dropper temperature are 80～85 ℃; Dripping speed is 30～50/minute.
2. above result shows, it is all good to test every index 4～No. 11, and promptly extract and substrate ratio are can drip system smoothly at 1: 1～1: 5 o'clock.But consider factors such as taking dose, optimum ratio is 4,6,8, No. 10 tests, and promptly extract and substrate ratio are 1: 1～1: 2.
Claims (3)
1. a dripping pills of schefflera arboricola is characterized in that adopting the Chinese crude drug Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) to make extract through extracting, and extract and drop pill substrate is formulated.The weight ratio of each composition is:
Radix Schefflerae Arboricolae extract: drop pill substrate=1: 1～1: 5
2. dripping pills of schefflera arboricola according to claim 1, it is characterized in that described drop pill substrate is polyethylene glycols, carboxymethyl starch sodium, poloxamer, a kind of or several compatibilities in sodium carboxymethyl cellulose, stearic acid, sodium stearate, the polyoxyethylene monostearate, the content of each compatibility composition all are not equal to zero.
3. according to claim 1 described dripping pills of schefflera arboricola, it is characterized in that preparation method is as follows: get the Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) medical material, decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction leaves standstill, and filters, filtrate is concentrated into the extractum that relative density is 1.12～1.22 (60 ℃), add ethanol and make that to contain the alcohol amount be 50%～70%, stir, leave standstill, get supernatant and reclaim ethanol, being concentrated into relative density is the extractum of 1.15～1.25 (60 ℃), adds ethanol again and makes that to contain alcohol amount be 60%～80%, stirs, leave standstill, get supernatant and reclaim ethanol, be condensed into extractum, extractum vacuum drying or spray drying are got extract.Get extract, pulverize, sieve.By weight be Radix Schefflerae Arboricolae extract: the ratio of drop pill substrate=1: 1～1: 5, join in the fused drop pill substrate, stir, splash in dimethicone or other coolant, separate drop pill, the absorption coolant, drying, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610049082 CN101002810A (en) | 2006-01-16 | 2006-01-16 | Dripping pills of schefflera arboricola, and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610049082 CN101002810A (en) | 2006-01-16 | 2006-01-16 | Dripping pills of schefflera arboricola, and its preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101002810A true CN101002810A (en) | 2007-07-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200610049082 Pending CN101002810A (en) | 2006-01-16 | 2006-01-16 | Dripping pills of schefflera arboricola, and its preparing method |
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| Country | Link |
|---|---|
| CN (1) | CN101002810A (en) |
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2006
- 2006-01-16 CN CN 200610049082 patent/CN101002810A/en active Pending
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