CN101002859A - Compounding Herba Andrographitis dripping pills, and its preparing method - Google Patents
Compounding Herba Andrographitis dripping pills, and its preparing method Download PDFInfo
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- CN101002859A CN101002859A CN 200610049085 CN200610049085A CN101002859A CN 101002859 A CN101002859 A CN 101002859A CN 200610049085 CN200610049085 CN 200610049085 CN 200610049085 A CN200610049085 A CN 200610049085A CN 101002859 A CN101002859 A CN 101002859A
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Abstract
A dripping pill of green chiretta for treating cold, tonsillitis, enteritis and urethritis is prepared from green chiretta and matrix. Its preparing process is also disclosed.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine pharmacy, particularly a kind of compounding Herba Andrographitis dripping pills and preparation technology thereof.
Background technology
Infectious disease, the most common with bacterial infection and viral infection.According to Chinese medical discrimination, actute infection belongs to the pyretic toxicity disease more, the treatment by Chinese herbs of available heat-clearing and toxic substances removing.Compound creat formulation is the compound Chinese patent medicine of anti-inflammation, is made up of Herba Andrographis, Herba Diclipterae Chinensis, has antibiotic, antiviral, antiinflammation.The Herba Andrographis main product in Guangdong, Fujian, all there is introducing and planting existing various places, north and south, the Changjiang river.Have heat-clearing and toxic substances removing, removing heat from blood, the repercussive function is used for cold, fever, laryngopharynx swelling and pain, aphtha of the mouth and tongue, an impairment and cough etc.The Herba Diclipterae Chinensis main product in the Hunan, Hubei, Jiangxi.Contain indigo glycoside, mountain cyrtophylin, to dysentery bacterium, meningococcus and leptospira have inhibitory action, have antibiotic, antiviral, analgesic, antiinflammatory action.Compound creat formulation is used for the treatment of bacterial infections such as viral infection such as flu, parotitis and intestinal, urethra clinically.Proved its anti-inflammation determined curative effect by medical circle.
The oral formulations of compound andrographis paniculata is a tablet in the market, and is coated tablet (the 19 of the Sanitation Ministry medicine standard Chinese patent medicine prescribed preparation, WS
3-B-3624-98).Because the conventional tablet fabricating technology has, and makes this class oral formulations exist disintegration long, absorption difference, onset is slow, and bioavailability is lower, thereby influences giving full play to of drug effect.Between the storage life, be easy to simultaneously sliver, variable color, the moisture absorption etc., quality instability.Compounding Herba Andrographitis dripping pills of the present invention has overcome the weak point of tablet, it is little to have taking dose, and disintegrate is molten looses soon the dissolution height, the bioavailability height, quality stability is good, release fast, the characteristics of produce effects fast, can sublingual administration, also can swallow, onset is faster than tablet, and is easy to carry and use.Preparation process of the present invention is simple, and workshop does not have dust, uses supplementary product kind few, and production process is short, steady quality, and cost is low.
Summary of the invention
The object of the invention provides a kind of pharmaceutical preparation one compounding Herba Andrographitis dripping pills and preparation technology thereof.Compounding Herba Andrographitis dripping pills of the present invention has heat-clearing and toxic substances removing, removing heat from blood, the function of dampness removing; Be used for bacterial infections such as viral infection such as flu, parotitis and intestinal, urethra.
The invention is characterized in and adopt Chinese crude drug Herba Andrographis, Herba Diclipterae Chinensis to make extract through extracting, extract and drop pill substrate is formulated.
The weight ratio of each composition is:
Herba Andrographis, Herba Diclipterae Chinensis extract: drop pill substrate=1: 1～1: 5
The percentage by weight (%) that the invention is characterized in each medical material is a Herba Andrographis 20～40, Herba Diclipterae Chinensis 60～80.
The optimum weight percentage ratio (%) that the invention is characterized in each medical material is Herba Andrographis 30, Herba Diclipterae Chinensis 70.
The present invention can be achieved through the following technical solutions:
Get 2～4 parts of Herba Andrographis, 6～8 parts of Herba Diclipterae Chinensises, decoct with water secondary, amount of water is 8～10 times of amounts first time, be 6～8 times of amounts for the second time, decocting time 2 hours for the first time, 1 hour for the second time, collecting decoction left standstill 12 hours, filtered, filtrate is concentrated into the extractum that relative density is 1.16～1.26 (60 ℃), adds ethanol and makes that to contain the alcohol amount be 60%～80%, stirs, left standstill 24 hours, get supernatant and reclaim ethanol, be condensed into extractum, extractum vacuum drying or spray drying are got extract.Get extract, pulverize, cross 100 mesh sieves.By weight being Herba Andrographis, Herba Diclipterae Chinensis extract: the ratio of drop pill substrate=1: 1～1: 5, join (85～90 ℃) in the fused drop pill substrate, stir, splash in dimethicone or other drop pill coolant (1～5 ℃), separate drop pill, absorb coolant, drying, promptly.
Utilize the drop pill of method preparation of the present invention, its main feature is:
1. the quick stripping of medicine, the dissolution height, rapid-action, the bioavailability height, side effect is little.Compounding Herba Andrographitis dripping pills is to adopt solid dispersion technology, with mixing after medicine and the fusion of drop pill substrate, solidifies by system of dripping and quenching, makes medicine be molecule, colloid or microcrystalline state and is scattered in the substrate.Because the gross area of medicine increases, medicine disengages with crystallite or unformed microgranule, so medicine dissolution and absorption quickening, and bioavailability improves.
2. medicine stability is good.Dropping pill formulation by medicine and substrate heating and melting after, splash in the immiscible liquid coolant and make, reduce with the air contact area, be difficult for oxidation, substrate is non-water thing, is difficult for causing drug hydrolysis, stability of drug is increased, thereby guaranteed drug quality.
3. increased administering mode.Compounding Herba Andrographitis dripping pills both can be swallowed, but buccal again, and the patient of being convenient to dysphagia takes.As adopt the sublingual administration administration, and and after contacting, saliva dissolves rapidly, absorb by oral mucosa, directly enter blood circulation without gastrointestinal tract and liver, not only avoided the liver sausage first-pass effect, and it is rapid to have reached onset, improve bioavailability, reduce the purpose of side effect.
4. drop pill production technology, production equipment are simple, with short production cycle, the production efficiency height, and cost is low.
5. in the main production process of drop pill, used material all is to carry out under liquid state, has reduced dust pollution, helps labor protection and environmental protection, helps the GMP management.
The specific embodiment
Further the present invention can be described by the following examples, but not limited by embodiment.
Embodiment one: get Herba Andrographis 900g, Herba Diclipterae Chinensis 2100g, decoct with water secondary, amount of water is 8 times of amounts first time, 6 times of amounts for the second time, decocting time 2 hours for the first time, 1 hour for the second time, collecting decoction left standstill 12 hours, filtered, filtrate is concentrated into the extractum that relative density is 1.16～1.26 (60 ℃), adds ethanol and makes that to contain the alcohol amount be 70%, stirs, left standstill 24 hours, get supernatant and reclaim ethanol, be condensed into extractum, the extractum vacuum drying is got extract.Get extract, pulverize, cross 100 mesh sieves.It is Herba Andrographis, Herba Diclipterae Chinensis extract by weight: Polyethylene Glycol
6000=1: 2 ratio joins in the molten matrix (87 ℃), stirs, and splashes into (3 ℃) in the dimethyl-silicon oil coolant, separates drop pill, absorbs coolant, drying, promptly.
Embodiment two: get the extract of embodiment one, pulverize, cross 100 mesh sieves.By weight being Herba Andrographis, Herba Diclipterae Chinensis extract: (mixed-matrix is a Polyethylene Glycol to the ratio of mixed-matrix=1: 2
6000: poloxamer was by 1: 0.2 prescription), join (87 ℃) in the fused mixed-matrix, stir, splash into (3 ℃) in the dimethyl-silicon oil coolant, separate drop pill, absorb coolant, drying, promptly.
Embodiment three: present embodiment is by Herba Andrographis, Herba Diclipterae Chinensis extract and different substrates prescription, investigates indexs such as roundness, the ball method of double differences are different, hardness, molten diffusing time, with the weight ratio of definite extract and single or mixed-matrix.
Herba Andrographis, Herba Diclipterae Chinensis extract and different substrates formula test (extract is 1 part)
Annotate: coolant is dimethicone or liquid paraffin, and chilling temperature is 1～5 ℃; Spice insulation and water dropper temperature are 85～90 ℃; Dripping speed is 30～50/minute.
Above result shows, it is all good to test every index 4,5,6,7, No. 8, and promptly extract and substrate ratio are can drip system smoothly at 1: 1～1: 5 o'clock.But consider factors such as taking dose, optimum ratio is 4,5,6, No. 8 tests, and promptly extract and substrate ratio are 1: 1～1: 2.
Claims (5)
1. a compounding Herba Andrographitis dripping pills is characterized in that adopting Chinese crude drug Herba Andrographis, Herba Diclipterae Chinensis to make extract through extracting, and extract and drop pill substrate is formulated.
The weight ratio of each composition is:
Herba Andrographis, Herba Diclipterae Chinensis extract: drop pill substrate=1: 1～1: 5
2. compounding Herba Andrographitis dripping pills according to claim 1 is characterized in that the percentage by weight (%) of each medical material is a Herba Andrographis 20～40, Herba Diclipterae Chinensis 60～80.
3. compounding Herba Andrographitis dripping pills according to claim 1 is characterized in that the percentage by weight (%) of each medical material is a Herba Andrographis 30, Herba Diclipterae Chinensis 70.
4. according to claim 1,2,3 described compounding Herba Andrographitis dripping pills, it is characterized in that described drop pill substrate is polyethylene glycols, carboxymethyl starch sodium, poloxamer, a kind of or several compatibilities in sodium carboxymethyl cellulose, stearic acid, sodium stearate, the polyoxyethylene monostearate, the content of each compatibility composition all are not equal to zero.
5. according to claim 1,2,3,4 described compounding Herba Andrographitis dripping pills, it is characterized in that preparation method is as follows: get 2～4 parts of Herba Andrographis, 6～8 parts of Herba Diclipterae Chinensises, decoct with water secondary, 2 hours for the first time, 1 hour for the second time, collecting decoction, leave standstill, filter, filtrate is concentrated into the extractum that relative density is 1.16～1.26 (60 ℃), add ethanol and make that to contain the alcohol amount be 60%～80%, stir, leave standstill, get supernatant and reclaim ethanol, be condensed into extractum, extractum vacuum drying or spray drying are got extract.Get extract, pulverize, sieve, by weight being Herba Andrographis, Herba Diclipterae Chinensis extract: the ratio of drop pill substrate=1: 1～1: 5, join in the fused drop pill substrate, stir, splash in dimethicone or other coolant, separate drop pill, absorb coolant, drying, promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610049085 CN101002859A (en) | 2006-01-16 | 2006-01-16 | Compounding Herba Andrographitis dripping pills, and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610049085 CN101002859A (en) | 2006-01-16 | 2006-01-16 | Compounding Herba Andrographitis dripping pills, and its preparing method |
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| Publication Number | Publication Date |
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| CN101002859A true CN101002859A (en) | 2007-07-25 |
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| CN 200610049085 Pending CN101002859A (en) | 2006-01-16 | 2006-01-16 | Compounding Herba Andrographitis dripping pills, and its preparing method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103604901A (en) * | 2013-11-18 | 2014-02-26 | 广州白云山和记黄埔中药有限公司 | Thin-layer identification method of compound andrographis tablet |
| CN107669718A (en) * | 2017-09-30 | 2018-02-09 | 广东罗浮山国药股份有限公司 | A kind of application of Chinese medicine composition in the medicine for preparing treatment acute urethritis |
-
2006
- 2006-01-16 CN CN 200610049085 patent/CN101002859A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103604901A (en) * | 2013-11-18 | 2014-02-26 | 广州白云山和记黄埔中药有限公司 | Thin-layer identification method of compound andrographis tablet |
| CN107669718A (en) * | 2017-09-30 | 2018-02-09 | 广东罗浮山国药股份有限公司 | A kind of application of Chinese medicine composition in the medicine for preparing treatment acute urethritis |
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