CN100594029C - Medicinal composition for injections in articular cavity - Google Patents
Medicinal composition for injections in articular cavity Download PDFInfo
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- CN100594029C CN100594029C CN200610103473A CN200610103473A CN100594029C CN 100594029 C CN100594029 C CN 100594029C CN 200610103473 A CN200610103473 A CN 200610103473A CN 200610103473 A CN200610103473 A CN 200610103473A CN 100594029 C CN100594029 C CN 100594029C
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- chondroitin sulfate
- pharmaceutical composition
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- hyaluronate sodium
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- 238000002347 injection Methods 0.000 title claims abstract description 11
- 239000007924 injection Substances 0.000 title claims abstract description 11
- 239000000203 mixture Substances 0.000 title claims description 11
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 28
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims abstract description 25
- 229920001287 Chondroitin sulfate Polymers 0.000 claims abstract description 25
- 229940059329 chondroitin sulfate Drugs 0.000 claims abstract description 25
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 20
- 238000002360 preparation method Methods 0.000 claims description 5
- 230000003204 osmotic effect Effects 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 3
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 claims description 3
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- 206010003246 arthritis Diseases 0.000 abstract description 3
- 230000008439 repair process Effects 0.000 abstract description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 abstract 3
- 229940010747 sodium hyaluronate Drugs 0.000 abstract 3
- 239000006173 Good's buffer Substances 0.000 abstract 1
- 239000002075 main ingredient Substances 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 description 20
- 201000008482 osteoarthritis Diseases 0.000 description 17
- 238000012360 testing method Methods 0.000 description 11
- 238000000034 method Methods 0.000 description 8
- 229920002683 Glycosaminoglycan Polymers 0.000 description 6
- 210000001188 articular cartilage Anatomy 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 239000013642 negative control Substances 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 230000002917 arthritic effect Effects 0.000 description 4
- 108090000526 Papain Proteins 0.000 description 3
- 239000004365 Protease Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 210000003127 knee Anatomy 0.000 description 3
- 229940055729 papain Drugs 0.000 description 3
- 235000019834 papain Nutrition 0.000 description 3
- 210000001179 synovial fluid Anatomy 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000007850 degeneration Effects 0.000 description 2
- 239000003862 glucocorticoid Substances 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 208000012659 Joint disease Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 235000018417 cysteine Nutrition 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002962 histologic effect Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 210000000629 knee joint Anatomy 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000011587 new zealand white rabbit Methods 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000009256 replacement therapy Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000001258 synovial membrane Anatomy 0.000 description 1
- 201000004595 synovitis Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides a pharmaceutical composition used for intra-articular injection, the main ingredients of which are sodium hyaluronate and chondroitin sulfate, wherein, the molecular weight of the sodium hyaluronate is 1.2 million to 5 million Daltons and the concentration is 0.5 percent to 2.0 percent, and the molecular weight of the chondroitin sulfate is 2000 to 15000 Daltons andthe concentration is 1 percent to 5 percent. The present invention has the advantages of good viscoelasticity and good buffer capacity of the sodium hyaluronate with relatively high molecular weight,as well as the advantages of rapid absorption and rapid repair of the chondroitin sulfate with relatively low molecular weight, thus the invention can be used for treating the arthritis by intra-articular injection.
Description
Technical field:
The invention belongs to medical technical field, a kind of medicinal composition for injections in articular cavity is provided.
Background technology:
Osteoarthritis is one of common clinically joint disease, is more common in the old people.Along with the prolongation of human average life and the continuous aggravation of aging society, the sickness rate of old people's osteoarthritis is also continuing rising, has seriously reduced old people's quality of life.Also therefore, arthritic treatment becomes the significant problem that needs to be resolved hurrily.
The osteoarthritis that a variety of causes causes all is from articular cartilage degeneration, and the change of sclerotin and synovial membrane takes place then, and the degeneration of cartilage comprises the change of chondrocyte and substrate.It is clinical mainly to show as cartilage destruction, disappearance, elasticity and weakens; The biological function lubricated and the opposing mechanism of knuckle synovia descends; Get involved etc. with synovitis, joint motion.
At present, for arthritic Drug therapy several different methods is arranged also, for example: control inflammation by giving glucocorticoid, but 2 distinct disadvantage of this method are: 1) though can cover arthritic pain symptom fast, amelioration of inflammation, but can not fundamentally improve the pathological changes of cartilage and knuckle synovia, the patient has often increased the weight of activity because of pain relief on the contrary, aggravated the lesion degree of cartilage and synovial fluid, arthritis is further increased the weight of; 2) glucocorticoid has tangible untoward reaction, has limited its application greatly.
From the eighties in last century, the viscoelasticity replacement therapy of osteoarthritis comes out, and promptly by intraarticular injection hyaluronate sodium (claiming hyaluronic acid sodium again) treatment osteoarthritis, and has obtained development of revolutionary significance.Hyaluronate sodium is as the important component part of knuckle synovia, the normal function of keeping synovial fluid is extremely important, make articular cartilage and synovial fluid have better elastic, in osteoarthritis patient's knuckle synovia, the molecular weight of hyaluronate sodium, concentration and viscoelasticity all obviously reduce, hyaluronate sodium by the son amount of directly awarding high marks in the articular cavity can directly improve knuckle synovia, and repairing articular cartilage progressively.The application of this method makes a lot of osteoarthritis patients obtain rehabilitation.Though can directly repair the cartilage of damage but use hyaluronate sodium separately, fundamentally treat osteoarthritis, reparation speed is slower, and the required course of treatment is longer.
Patent CN 02822420.5 and US2006003964 all disclose the arthritic method of drug treatment in hyaluronate sodium and the chondroitin sulfate use in conjunction articular cavity, and this method is the progress again on the basis of using hyaluronate sodium separately.But, and of the present inventionly discover the best results of hyaluronate sodium and chondroitin sulfate use in conjunction in specific molecular weight ranges in a large number according to the pathogenesis and the clinical manifestation of osteoarthritis.Because, chondroitin sulfate is the important substance that constitutes articular cartilage, chondroitin sulfate is as one of composition of cartilage, can participate in the structure of cartilage directly, quicken the regeneration and the reparation of cartilage, and can keep moisture, and make the nutritional labeling rapid osmotic to cartilage, this is extremely important to the cartilage that does not have blood supply.Articular cartilage absorbs ectogenic chondroitin sulfate, and progressively is converted into the part of articular cartilage self, and in this absorption process, the chondroitin sulfate of small-molecular weight is easier is relatively absorbed by cartilage.Having mentioned above for the hyaluronate sodium that is used for the treatment of osteoarthritis then requires molecular weight higher.
By last we as can be seen, hyaluronate sodium and chondroitin sulfate use in conjunction will reach optimum therapeuticing effect, then should satisfy following 2 points: 1) hyaluronate sodium must have higher molecular weight, has only this, could resist the obvious reduction of molecular weight, concentration and the viscoelasticity of hyaluronate sodium in the osteoarthritis patient knuckle synovia, recover the cushion pad and the lubrication of knuckle synovia; 2) chondroitin sulfate must have relatively low molecular weight, so that the treatment of osteoarthritis is accelerated in the fast Absorption of cartilage and reparation.The present invention has promptly proposed a kind of medicinal composition for injections in articular cavity on this research basis, met above-mentioned requirements.
Summary of the invention:
The invention provides a kind of medicinal composition for injections in articular cavity, the main component that it is characterized in that this pharmaceutical composition is hyaluronate sodium and chondroitin sulfate, wherein the molecular weight of hyaluronate sodium is 1,200,000～5,000,000 dalton, preferred 150～3,000,000 dalton, first-selected 150～2,000,000 dalton, the molecular weight of chondroitin sulfate is 2000～15000 dalton, preferred 4000～12000 dalton, first-selected 6000～8000 dalton.
The concentration of hyaluronate sodium is 0.5%～2.0% in the aforementioned pharmaceutical compositions, preferred 0.8%～1.2%, first-selected 1%.
The concentration of chondroitin sulfate is 1%～5% in the aforementioned pharmaceutical compositions, preferred 2%～3%, first-selected 2%.
Except that hyaluronate sodium and 2 kinds of main components of chondroitin sulfate, also contain the conventional dose adjuvant in the aforementioned pharmaceutical compositions, can be made into any dosage form that is used for intraarticular injection, first-selected liquid preparation and gel.
Aforementioned pharmaceutical compositions is used for drug treatment bone-specific drug arthritis in the articular cavity.
The consumption of aforementioned pharmaceutical compositions is: a drug dosage of each articular cavity is 1.5～3ml, preferred 2.0～2.5ml, first-selected 2.0ml.
Aforementioned pharmaceutical compositions is according to osteoarthritis conditions of patients difference, and its medicine frequency and cycle are: medication in per 5～8 days once, each treatment cycle was 3～8 weeks.
The pH scope of aforementioned pharmaceutical compositions is 6.5～7.5, and preferred pH scope is 6.8～7.4, and first-selected pH scope is 7.0～7.4; The osmotic pressure scope be 220～360 the milli ooze equivalent/liter, preferred 270～330 the milli ooze equivalent/liter.
The specific embodiment:
Embodiment 1: a kind of gel of articular cavity inner injecting and administering
Prescription:
Embodiment 3: a kind of liquid preparation of articular cavity inner injecting and administering
Prescription:
Embodiment 3: a kind of gel of articular cavity inner injecting and administering
Prescription:
Test data:
The effectiveness study of 1 pair of osteoarthritis of the embodiment of the invention
The preparation of 1 test specimen
1. test group: the embodiment of the invention 1.
2. contrast 1 group: get relative low-molecular-weight (800,000 dalton's) hyaluronate sodium 1g, relatively low-molecular-weight (8000 dalton) chondroitin sulfate 2g, all the other are with the embodiment of the invention 1.
3. contrast 2 groups: get relative low-molecular-weight (800,000 dalton's) hyaluronate sodium 1g, relatively high molecular (50000 dalton) chondroitin sulfate 2g, all the other are with the embodiment of the invention 1.
4. contrast 3 groups: get relative high molecular (1,500,000 dalton's) hyaluronate sodium 1g, relatively high molecular (50000 dalton) chondroitin sulfate 2g, all the other are with the embodiment of the invention 1.
5. negative control group: normal saline.
The grouping of 2 experimental animals
Get 40 of healthy new zealand white rabbits, body weight 2～3kg, male and female are not limit, and are divided into 5 groups at random: 1. test group; 2. contrast 1 group; 3. contrast 2 groups; 4. contrast 3 groups; 5. negative control group.
3 osteoarthritis Preparation of model and administrations
Cause the osteoarthritis varying model by injecting papain in the articular cavity, to injecting papain solution 0.1ml (the 1ml normal saline contains the 1.8mg papain, the 50mg cysteine) respectively in the right knee joint cavity of 5 groups of rabbits.After 3 days, inject again the 2nd time, inject altogether 2 times.After modeling the 7th day, 5 groups of test rabbits are injected above-mentioned sample 0.3ml in the same area of articular cavity respectively, 1 time weekly, totally 5 weeks.
The the gathering and processing and detecting of 4 samples
Rabbit is put to death in after last injection the 7th day.Scrape and get rabbit knee hair on every side, open the capable gross examination of skeletal muscle of articular cavity, complete then taking-up cartilage, major part are used for GAG content and measure (main component of cartilage glycosaminoglycans is a chondroitin sulfate, the content of the content direct reaction chondroitin sulfate of glycosaminoglycans), a small amount of cartilaginous tissue is fixed, dehydration routinely, paraffin embedding, the section of being cut into 5～6nm then, do HE, the dyeing of A Li Xinlan respectively, the section om observation.
5 results
1) according to Mankin osteoarthritis histologic classification method, cartilage is marked, the results are shown in Table 1.
Each animal groups knee cartilage om observation appraisal result of table 1
Each test group result is carried out statistical analysis to be shown: each administration group all has utmost point significant difference with negative control group, and wherein the integration of test group significantly is lower than each matched group, and therapeutic effect the best of the embodiment of the invention 1 is described.
2) adopt reddish black A method to measure the content of glycosaminoglycans, each is organized, and the content of glycosaminoglycans is converted into the contained sample size (x ± s), the results are shown in Table 2 of every 1mg cartilage weight in wet base in the sample.
The content of glycosaminoglycans in the table 2 different animals group knee cartilage
Each group result is carried out statistical analysis to be shown: test group, 3 matched groups are compared with negative control group, and significant difference is all arranged, and test group is compared with 3 matched groups and negative control group also all significant difference.Be the hyaluronate sodium and the chondroitin sulfate of same concentrations although show the main component of test group and 3 matched groups, but because of molecular weight need not, curative effect is also different, the test group embodiment of the invention 1 shows better therapeutic, what can alleviate cartilage moves back the change of shape property, and the content that effectively suppresses glycosaminoglycans in the cartilage reduces.
Claims (11)
1. a medicinal composition for injections in articular cavity is characterized in that this pharmaceutical composition contains hyaluronate sodium and chondroitin sulfate, and wherein the molecular weight of hyaluronate sodium is 150～2,000,000 dalton, and concentration is 0.5%～2.0%; The molecular weight of chondroitin sulfate is 6000～8000 dalton, and concentration is 1%～5%.
2. the described pharmaceutical composition of claim 1, the concentration that it is characterized in that hyaluronate sodium is 0.8%～1.2%.
3. the described pharmaceutical composition of claim 1, the concentration that it is characterized in that hyaluronate sodium is 1%.
4. the described pharmaceutical composition of claim 1, the concentration that it is characterized in that chondroitin sulfate is 2%～3%.
5. the described pharmaceutical composition of claim 1, the concentration that it is characterized in that chondroitin sulfate is 2%.
6. the arbitrary described pharmaceutical composition of claim 1-5 is characterized in that compositions is liquid preparation or gel.
7. the arbitrary described pharmaceutical composition of claim 1-5, the pH scope that it is characterized in that compositions is 6.5～7.5.
8. the described pharmaceutical composition of claim 7 is characterized in that described pH scope is 6.8～7.4.
9. the described pharmaceutical composition of claim 7 is characterized in that described pH scope is 7.0～7.4.
10. the arbitrary described pharmaceutical composition of claim 1-5, the osmotic pressure scope that it is characterized in that compositions be 220～360 millis ooze equivalent/liter.
11. the described pharmaceutical composition of claim 10, the osmotic pressure scope that it is characterized in that compositions be 270～330 the milli ooze equivalent/liter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610103473A CN100594029C (en) | 2006-07-24 | 2006-07-24 | Medicinal composition for injections in articular cavity |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200610103473A CN100594029C (en) | 2006-07-24 | 2006-07-24 | Medicinal composition for injections in articular cavity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101112381A CN101112381A (en) | 2008-01-30 |
| CN100594029C true CN100594029C (en) | 2010-03-17 |
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| CN200610103473A Active CN100594029C (en) | 2006-07-24 | 2006-07-24 | Medicinal composition for injections in articular cavity |
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| CN (1) | CN100594029C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027348A (en) * | 2010-12-28 | 2014-09-10 | 德普伊米特克公司 | Compositions and methods for treating joints |
| CN105982912A (en) * | 2015-03-02 | 2016-10-05 | 黄绣川 | Pharmaceutical composition containing sodium hyaluronate and chondroitin sulfate |
| US10532069B2 (en) | 2015-01-20 | 2020-01-14 | DePuy Synthes Products, Inc. | Compositions and methods for treating joints |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1394570B1 (en) * | 2009-07-02 | 2012-07-05 | Fidia Farmaceutici | BIOLOGICAL MATERIAL SUITABLE FOR THE OSTEOARTROSIS THERAPY OF TAPER DAMAGE AND FOR THE TREATMENT OF JOINT-PATHOLOGIES. |
| ITPD20120098A1 (en) * | 2012-03-30 | 2013-10-01 | Fidia Farmaceutici | "NEW PHARAMACEUTICAL FORMULATIONS CONTAINING CONDROITIN SULFATE AND DERIVATIVES OF HYALURONIC ACID" |
| ITMI20132116A1 (en) | 2013-12-18 | 2015-06-19 | Apharm Srl | ASSOCIATION OF GLYCOSAMINOGLICANS AND CYCLODESTRINES |
| CN105920031A (en) * | 2016-04-21 | 2016-09-07 | 李媚 | Composition for joint repair and preparation method of composition |
| CN107303271A (en) * | 2016-04-25 | 2017-10-31 | 惠觅宙 | A kind of parenteral solution containing micromolecule hyaluronic acid and application thereof |
-
2006
- 2006-07-24 CN CN200610103473A patent/CN100594029C/en active Active
Non-Patent Citations (1)
| Title |
|---|
| 透明质酸与骨关节炎. 郑昱新，石印玉.Chinese J Trad Med Traum & Orthop.,Vol.7 No.4. 1999 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104027348A (en) * | 2010-12-28 | 2014-09-10 | 德普伊米特克公司 | Compositions and methods for treating joints |
| CN104027348B (en) * | 2010-12-28 | 2017-09-08 | 德普伊米特克公司 | Composition and method for treating joint |
| US11090328B2 (en) | 2010-12-28 | 2021-08-17 | Medos International Sarl | Compositions and methods for treating joints |
| US10532069B2 (en) | 2015-01-20 | 2020-01-14 | DePuy Synthes Products, Inc. | Compositions and methods for treating joints |
| CN105982912A (en) * | 2015-03-02 | 2016-10-05 | 黄绣川 | Pharmaceutical composition containing sodium hyaluronate and chondroitin sulfate |
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| Publication number | Publication date |
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| CN101112381A (en) | 2008-01-30 |
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Effective date of registration: 20190108 Address after: 250101 989 Xinjie street, Ji'nan high tech Zone, Shandong Patentee after: Pharmaceutical Sciences, Shandong Province Address before: 250014 No. 264 Shanda Road, Lixia District, Jinan City, Shandong Province Patentee before: Ling Peixue |
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