CN100584370C - The Chinese medicine of control alimentary tract cancer - Google Patents
The Chinese medicine of control alimentary tract cancer Download PDFInfo
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- CN100584370C CN100584370C CN200710054427A CN200710054427A CN100584370C CN 100584370 C CN100584370 C CN 100584370C CN 200710054427 A CN200710054427 A CN 200710054427A CN 200710054427 A CN200710054427 A CN 200710054427A CN 100584370 C CN100584370 C CN 100584370C
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Abstract
The present invention relates to a kind of Chinese medicine and production method thereof of preventing and treating alimentary tract cancer, the medication that can effectively solve alimentary tract cancer prevents and treats problem, the technical scheme of its solution is, adopt the Radix Astragali, Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, Lignum Aquilariae Resinatum, Flos Caryophylli, Rhizoma Curcumae, rhizoma sparganic, Rhizoma Chuanxiong, Rhizoma Pinelliae, Semen Sinapis Albae, Herba Euphorbiae Helioscopiae, Herba Lobeliae Chinensis, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Spica Prunellae, eupolyphaga, Hirudo, Tabanus and water are made, its production method is, earlier Rhizoma Pinelliae is placed on and adds water in pot cage and steam, eliminate toxicity, and then the same Radix Astragali, Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, Lignum Aquilariae Resinatum, Flos Caryophylli, Rhizoma Curcumae, rhizoma sparganic, Rhizoma Chuanxiong, Semen Sinapis Albae, Herba Euphorbiae Helioscopiae, Herba Lobeliae Chinensis, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Spica Prunellae water submergence together, after the immersion, decoct twice, merge decocting liquid twice, again with eupolyphaga, mixing gets final product in twice decocting liquid after Hirudo and Tabanus are ground into powder and add merge, prescription science of the present invention, can be effective to prevent and treat gastral various cancer, huge economic and social benefit is arranged.
Description
One, technical field
The present invention relates to field of medicaments, particularly a kind of Chinese medicine and production method thereof of preventing and treating alimentary tract cancer.
Two, background technology
Recently, data shows, various cancers have become the first human killer, various cancers common frdquently encountered disease especially in the digestive tract particularly, as the esophageal carcinoma, this pernicious kind of tumor from epithelium of esophagus, the whole world has 300,000 people to die from the esophageal carcinoma every year approximately, and wherein China accounts for 50%, morbidity is many more than 40 years old, male more than the woman, and along with industrial pollution, the deterioration of living environment, its sickness rate has the trend of rising, have a strong impact on people's healthy and life security, for this reason, countries in the world are all making great efforts to capture this difficult problem medically of cancer, and the medicine for the treatment of alimentary tract cancer at present is a lot, must restrain as the Chinese medicine cancer, Western medicine has fluorouracil, calcium folinate and fluorofur etc. also have various vitamin, as vitamin V B
2, VB
6, VC, VE, VK etc., the Therapeutic Method that also adopts operation and chemotherapy to combine clinically, but its effect and meaning for various reasons not to the utmost with medicine, people look forward to having the medicine of new anti-treatment alimentary tract cancer.
Three, summary of the invention
At above-mentioned situation, the present invention's purpose just provides a kind of Chinese medicine and production method thereof of new control alimentary tract cancer, the medication that can effectively solve alimentary tract cancer prevents and treats problem, as everybody knows, cancer therefrom medically says it is a kind of noxious dampness or title malignant boil, be to cause due to the resistance of the phlegm-damp stasis of blood by QI and blood retardance meridians, or perhaps vital QI being weakened and pathogen being violent, weakened body resistance then anti-evil underactivity, form the body of susceptible, the domination of pathogen then comprises the poison Sheng, the expectorant knot, blood stasis and to form tangible knot poly-, the position internal organs difference that its knot is poly-, form the cancerous protuberance of different parts, the malignant tumor that alimentary tract cancer promptly forms at the digestive tract position, so the rule of treatment of control is a strengthening vital QI to eliminate pathogenic factors, adopt dialectical treatment and prevention, treatment must aim at the pathogenesis of disease, treating both the principal and secondary aspects of a disease, defeated logical digestive tract, dehumidifying, reduce phlegm, draw out pus by applying a plaster to the affected part, hard masses softening and resolving, the control principle of putrefaction-removing granulation-promoting, so the technical scheme that the present invention solves is, adopt the Radix Astragali, Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, Lignum Aquilariae Resinatum, Flos Caryophylli, Rhizoma Curcumae, rhizoma sparganic, Rhizoma Chuanxiong, Rhizoma Pinelliae, Semen Sinapis Albae, Herba Euphorbiae Helioscopiae, Herba Lobeliae Chinensis, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Spica Prunellae, eupolyphaga, Hirudo, Tabanus and water are made, its production method is, earlier Rhizoma Pinelliae is placed on and adds water in pot cage and steam, eliminate toxicity, and then the same Radix Astragali, Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, Lignum Aquilariae Resinatum, Flos Caryophylli, Rhizoma Curcumae, rhizoma sparganic, Rhizoma Chuanxiong, Semen Sinapis Albae, Herba Euphorbiae Helioscopiae, Herba Lobeliae Chinensis, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Spica Prunellae water submergence together after the immersion, decocts twice, merge decocting liquid twice, again with eupolyphaga, mixing gets final product in twice decocting liquid after Hirudo and Tabanus are ground into powder and add merge.
Prescription science of the present invention, abundant raw materials, cost is low, easily produces and takes, and not only can cure the disease but also can diseases prevention, and is widely applicable, can be effective to prevent and treat gastral various cancer, and it is succeeded in developing, and is a creation on the Chinese medicine, and huge economic and social benefit is arranged.
Four, the specific embodiment
Below in conjunction with concrete condition and embodiment the specific embodiment of the present invention is elaborated.
Provide by technical scheme, Chinese medicine of the present invention is to be made by Radix Astragali 15-25g, Pericarpium Citri Reticulatae Viride 10-14g, Radix Aucklandiae 10-14g, Lignum Aquilariae Resinatum 2-4g, Flos Caryophylli 2-4g, Rhizoma Curcumae 7-13g, rhizoma sparganic 7-13g, Rhizoma Chuanxiong 7-13g, Rhizoma Pinelliae 7-13g, Semen Sinapis Albae 7-13g, Herba Euphorbiae Helioscopiae 12-18g, Herba Lobeliae Chinensis 12-18g, Herba Scutellariae Barbatae 12-18g, Herba Hedyotidis Diffusae 15-25g, Spica Prunellae 15-25g, eupolyphaga powder, Hirudo powder, Tabanus powder and water, and eupolyphaga powder, Hirudo powder, Tabanus powder addition are eupolyphaga powder 1.5-2.5g, Hirudo powder 0.8-1.2g in the medicinal liquid of the fried one-tenth of every 500ml, Tabanus powder 0.8-1.2g.
Aborning, add eupolyphaga powder 2g, Hirudo powder 1g and Tabanus powder 1g in the herb liquid that Chinese medicine embodiment of the present invention specifically can be made by Radix Astragali 20g, Pericarpium Citri Reticulatae Viride 12g, Radix Aucklandiae 12g, Lignum Aquilariae Resinatum 3g, Flos Caryophylli 3g, Rhizoma Curcumae 10g, rhizoma sparganic 10g, Rhizoma Chuanxiong 10g, Rhizoma Pinelliae 10g, Semen Sinapis Albae 10g, Herba Euphorbiae Helioscopiae 15g, Herba Lobeliae Chinensis 15g, Herba Scutellariae Barbatae 15g, Herba Hedyotidis Diffusae 20g, Spica Prunellae 20g and decocting and make, the addition of water can be 1500-2000ml.
The production method that realizes above-mentioned Chinese medicine is, at first Rhizoma Pinelliae is removed its earth, clean, be placed on and steam 2-3 hour on the steamer, eliminate toxicity, taking-up is dried, and then add water to submerge by the same Radix Astragali of prescription requirement, Pericarpium Citri Reticulatae Viride, the Radix Aucklandiae, Lignum Aquilariae Resinatum, Flos Caryophylli, Rhizoma Curcumae, rhizoma sparganic, Rhizoma Chuanxiong, Semen Sinapis Albae, Herba Euphorbiae Helioscopiae, Herba Lobeliae Chinensis, Herba Scutellariae Barbatae, Herba Hedyotidis Diffusae, Spica Prunellae, soaking the back decocts twice, merge twice decocting liquid and become herb liquid, in herb liquid, add again eupolyphaga powder, Hirudo powder and Tabanus powder mixing Chinese medicine to be taken.
For example, among the production method embodiment of the present invention, specifically can earlier Rhizoma Pinelliae be placed in the food steamer of rustless steel steamer and steam 2.5 hours, eliminate toxicity, taking-up is dried, Rhizoma Pinelliae 10g after usefulness steams is with Radix Astragali 20g, Pericarpium Citri Reticulatae Viride 12g, Radix Aucklandiae 12g, Lignum Aquilariae Resinatum 3g, Flos Caryophylli 3g, Rhizoma Curcumae 10g, rhizoma sparganic 10g, Rhizoma Chuanxiong 10g, Semen Sinapis Albae 10g, Herba Euphorbiae Helioscopiae 15g, Herba Lobeliae Chinensis 15g, Herba Scutellariae Barbatae 15g, Herba Hedyotidis Diffusae 20g, Spica Prunellae 20g puts into the medicine pot together and adds water 1500ml, soaked 30-60 minute, decoct again twice, filter, merge filtrate twice, herb liquid after must decocting is concentrated into 500ml, in the 500ml herb liquid, add eupolyphaga powder 2g again, Hirudo powder 1g and Tabanus powder 1g mixing promptly get Chinese medicine of the present invention (oral liquid).
In above-mentioned Chinese medicine component, wherein:
The Radix Astragali: spring, autumn excavate.Time spent soaks former liquid medicine, run through, and cuts into slices, dries, and has qi-supplementing, blood-engendering, the function of consolidating superficial resistance evacuation of pus; Pericarpium Citri Reticulatae Viride: clean with the water logging bubble, be cut into thick about 0.5 centimetre sheet, dried depressed liver-energy dispersing and QI regulating, the stomach function regulating removing food stagnancy; The Radix Aucklandiae: remove clean earth, be cut into 6-10 centimeter length section, dry or fire drying, time spent clear water profit is soft, section, but promoting the circulation of QI to relieve pain, and intestinal stasis relieving is good for the stomach; Lignum Aquilariae Resinatum: pulverizing, go into decoct, sending down the abnormal ascending QI, warming middle-JIAO, warming the kidney; Rhizoma Curcumae: clean, section is dried, energy circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving; Rhizoma Chuanxiong: remove clean rice shoot, earth, after drying or drying, hit fibrous root, immersion, vexed, section is dried, and invigorates blood circulation circulation of qi promoting, the function of wind-expelling pain-stopping; Rhizoma Pinelliae: the first water in back that is unearthed is washed in a pan and is removed earth, towards it, removes clean crust with water, and after steaming, taking-up is dried, and drying dampness to eliminate phlegm is arranged, the function of stopping nausea and vomiting by lowering the adverse flow of QI; Semen Sinapis Albae: Herb is regained, and dries, and lays seed, remove shell, impurity such as branch, former medicine is smashed, promoting the circulation of QI reduces phlegm, removing obstruction for relieving pain; Herba Euphorbiae Helioscopiae: gather summer, cleans, and dries in the shade, and strong permeability is arranged, and not only has diuretic, the function of expectorant, and analgesic hemostatic, putrefaction removing blood stasis dispelling; Eupolyphaga: have another name called ground beetle, go into after catching in the boiling water to scald extremely, dry, be ground into the eupolyphaga powder, function is the diffusing disease of removing blood stasis, the continuous damage of stimulating the menstrual flow; Hirudo powder: the Hirudo 5-6 month catches and gets, and dries, and is ground into Hirudo powder, and removing blood stasis is arranged, the function that diffusing disease is stimulated the menstrual flow; Tabanus powder: boil soup bubble of Tabanus is washed, dried, remove the wing foot, fry, be ground into powder, the removing blood stasis blood stasis removing is arranged, the effect of eliminating stagnation eliminating mass; Herba Lobeliae Chinensis: be the herb of Herba Lobeliae Chinensis, remove clean earth impurity, dry, cutting has detoxifcation, heat clearing away, convenient function; Herba Scutellariae Barbatae: be the herb of Herba Scutellariae Barbatae, clean, cutting, dry to have heat-clearing and toxic substances removing, an anticancer effect of invigorating blood circulation; Herba Hedyotidis Diffusae: be the herb of Herba Hedyotidis Diffusae, clean, shred, dry to have detoxicating and fighting cancer, the function of diuresis of blood circulation promoting; Spica Prunellae: be the spica or the herb of Spica Prunellae, clean, cutting, dry, but the heat clearing away eliminating stagnation, liver heat removing and eyesight improving; Rhizoma sparganic: be the underground rhizome of rhizoma scirpi, remove its crust and fibrous root, residual stem, dry, fry or wheat bran is fried the circulation of qi promoting removing blood stasis is arranged, cut the function of hard eliminating stagnation, be used for abdominal pain due to blood stasis, the treatment of lump in the abdomen with vinegar.
By above drug component as can be known, science compatibility between its component, through preparation, have on the function and support mutually, improve curative effect, have blood circulation promoting and blood stasis dispelling, eliminating stagnation, separate vicious, supplementing QI and nourishing YIN, consolidate, effectively reach the purpose of anti-curing cancers, clinical data has obtained also fully proving that concrete clinical data is as follows:
One, selects the standard of case
Various symptoms clinical that every digestive tract has a cancerous protuberance be in hospital and the out-patient all as the standard of selection case.
Two, diagnostic criteria
Press establishment diagnostic criteria of new Chinese medicine clinical development guideline and test case standard that health ministry is formulated.
Three, therapeutic scheme
Sooner or later service once Chinese medicine of the present invention (Chinese medicine oral liquid) every day, each oral 200-250ml, each month is a course of treatment, can take observe the curative effect after the course of treatment continuously, after three courses of treatment, whether decision continues to take Chinese medicine of the present invention, statistical result in 3 years, at it simultaneously, if animal groups is tested, to judge its toxicity and clinical meaning.
Four, efficacy assessment standard
Press the evaluation criteria of health ministry regulation and carry out, generally can be considered:
1, produce effects or healing: the cancer kind disappears, and transference cure lives that all are normal, and in 5 years recurrence is not arranged.
2, effective: cancerous protuberance and symptom have obtained to a certain degree improving, and have delayed further developing and worsening of the state of an illness, have prolonged patient's life span to a certain extent.
3, invalid: symptom does not have any improvement, even the trend that increases the weight of is arranged.
Five, statistical procedures
1, preventive usage
China is the district occurred frequently of alimentary tract cancer, it is especially important that preventative work seems, conduct vigorous propaganda the policy of putting prevention first, when popularizing anticancer knowledge, improve bad life, dietary habit, polyphagia is improved drinking-water etc. with fresh vegetables, fruit, but can take chemoprophylaxis, the VB that takes as usual simultaneously
2, VB
6VC, VE, VK etc., because these measures are medicine particularly, efficient is limited, and expense height, be difficult to adhere to and popularize, thus the applicant with the Chinese medicine of the present invention of its invention in people more than 1000 on probation (having selected the residential block of a mountain area condition difference), statistics in 3 years, contrast with another residential block under the same terms, there is not 7 people generation cancerous protuberance in various degree in the medication district in 3 years, dead 6 people, and there is the cancerous protuberance phenomenon in medication district only 1 people, the tool investigation, this patient does not adhere to medication, the time usefulness when disconnected, do not have dead (reagent person all think former healthy person), this shows that medicine of the present invention has the bullate effect of good preventing digestive tract cancer.
2, clinical therapeutic efficacy
Through treating to suffering from digestive tract cancerous protuberance patient, the wherein esophageal carcinoma 86 people, intestinal cancer 94 people, gastric cancer 75 people, amount to 255 people, undertaken by above-mentioned therapeutic scheme, and establish matched group 56 people's controlled observations, and matched group is taken fluorouracil, vincristine etc., and the experimental group patient services once herb liquid of the present invention sooner or later, each 250ml, concrete condition such as following table:
(1), controls back life cycle (controlling the back survival rate)
| Life cycle | 6 months | 1 year | 2 years | 3 years | 4 years | 5 years | More than 5 years |
| Experimental group 255 people | 3 people | 8 people | 26 people | 53 people | 77 people | 64 people | 24 people |
| Matched group 56 people | 4 people | 13 people | 12 people | 11 people | 10 people | 3 people | 1 people |
(2), quality of life is improved situation, employing Karnofsky standards of grading
| Grouping | 100 | 90 | 80 | 70 | 60 | 50 | 40 | 30 | 20 | 10 | 0 |
| Experimental group 255 people | 84 | 42 | 28 | 27 | 22 | 16 | 12 | 10 | 7 | 5 | 2 |
| Matched group 56 people | 1 | 3 | 1 | 6 | 5 | 10 | 6 | 6 | 4 | 3 | 2 |
(3), the focus objective indicator is improved situation
Of the present invention as can be seen group on average can be improved survival rate to alimentary tract cancer and reach 4 years from last each table, matched group on average only improved 2 years, the two has significant difference, aspect improving the quality of living, can on average improve branch more than 70 by the Karnofsky standards of grading after taking the present invention, matched group can on average only improve 50 fens, apparently higher than matched group, aspect focus improves, the present invention is alleviated 50% patient fully, and matched group less than 2%, thus also as can be seen, the present invention has absolute advantages aspect relief of symptoms.
Six, animal toxicity experiment
After irritating the stomach various dose for the animal per os with medicine of the present invention, each treated animal did not all have tangible toxic reaction and death in 7 days; Carry out the mtd test of this product on this basis; Promptly give animal this product Cmax (2g/ml crude drug), the maximum volume (0.4ml/10g body weight) that allows, 2 times on the one, total amount reaches 160g/kg, and tangible toxic reaction and death do not appear in all animals yet.
Test objective:
Observation is subjected to the reagent thing to irritate toxic reaction and the dead distribution situation that is produced behind the stomach once for the animal per os.
Be subjected to the reagent thing: medicine of the present invention, be decocting solution, concentration is that 2g/ml contains crude drug in whole.
Experimental animal: Kunming kind healthy mice, raise and body weight 20 ± 2g, male and female dual-purpose are provided by Henan Province's animal center.
Test method and result
Trial test
Get 30 of animals, be divided into 3 groups at random, 10 every group:
(1) 80g/kg: concentration is 200%, the 0.4ml/10g body weight;
(2) 60g/kg: concentration is 150%, the 0.4ml/10g body weight;
(3) 40g/kg: concentration is 100%, the 0.4ml/10g body weight;
After once gavaging this product for above each treated animal, in 7 days, all there are not any toxic reaction and death.Carry out mtd test in a day on this basis.
Mtd test:
Get 20 of animal health mices, male and female half and half, fasting 12 hours; About at 9 o'clock in the morning, gavage this product 0.8ml/20 body weight (200% concentration) once for every Mus, be administered once with same dose at 3 o'clock in afternoon again, it is 160g/kg that a daily amount is equivalent to crude drug in whole, and tangible toxic reaction and death did not appear in all animals yet in 7 days.Above-mentionedly show that fully medicine of the present invention has no side effect, and takes safety.
Seven, the effect of animal solid type sarcoma growth inhibited is tested
Irritate the stomach various dose for the animal per os with medicine of the present invention, the continuous use growth to animal solid type sarcoma Siso in 8 days has the obvious suppression effect, has compared significant difference with matched group, and has tangible dose-response relationship (P＜0.05)
Test objective:
Irritate stomach medicinal liquid various dose of the present invention for the animal per os, observe the situation that influences, for clinical application provides scientific basis to the animal tumor growth in vivo.
Be subjected to the reagent thing:
Medicine of the present invention is the dark-brown water decoction, and containing the crude drug amount is 0.2g/ml.
Animal: Kunming kind healthy mice, body weight 21 ± 2g is raised and is provided by Henan Province's animal center.
The tumor strain: therefrom state's medical courses in general institute, Beijing medicine are introduced, and during test cell dilution are become 2,500 ten thousand/ml cell number, inoculate.
Method: get 30 of animals, only diluted good tumor cell suspension 0.2ml/ from the subcutaneous vaccination of animal liquid, be divided into 3 groups at random, 10 every group, each agent group is:
| Matched group | Tap water | 30ml/kg | 0.3ml/10g | |
| Heavy dose of group | Medicinal liquid of the present invention | 6g/kg | 20％ | 0.3ml/10g |
| Small dose group | Medicinal liquid of the present invention | 4g/kg | 13.3％ | 0.3ml/10g |
More than the examination that is subjected to that gavages various dose of each group organize, logotype once a day 8 days, in the 10th day with sacrifice of animal, get tumor and weigh, calculate tumor control rate, and observe the weight of animals situation of change at different time simultaneously, the results are shown in following table:
Inhibitory action to animal solid type sarcoma Siso growth
P＜0.05 and P＜0.01 is all compared with matched group.
Experimental result shows: gavage the medicinal liquid of various dose to animal, logotype 8 days has obvious inhibitory action to the growth of animal solid type sarcoma Siso.Compare with matched group and to have significant difference.
Eight, conclusion
By above-mentioned situation, clearly show, Chinese medicine of the present invention has the effect of blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, putrefaction-removing granulation-promoting, strengthening vital QI to eliminate pathogenic factors, be effective to prevent and treat alimentary tract cancer, remarkably productive, and have no side effect, clinical meaning is huge, be that its application must be brought benefit to the mankind to the creationary contribution of Chinese medicine and pharmacy.
Claims (1)
1, a kind of Chinese medicine of preventing and treating alimentary tract cancer, it is characterized in that, earlier Rhizoma Pinelliae is placed in the food steamer of rustless steel steamer and steamed 2.5 hours, eliminate toxicity, taking-up is dried, Rhizoma Pinelliae 10g after reuse steams is with Radix Astragali 20g, Pericarpium Citri Reticulatae Viride 12g, Radix Aucklandiae 12g, Lignum Aquilariae Resinatum 3g, Flos Caryophylli 3g, Rhizoma Curcumae 10g, rhizoma sparganic 10g, Rhizoma Chuanxiong 10g, Semen Sinapis Albae 10g, Herba Euphorbiae Helioscopiae 15g, Herba Lobeliae Chinensis 15g, Herba Scutellariae Barbatae 15g, Herba Hedyotidis Diffusae 20g, Spica Prunellae 20g puts into the medicine pot together and adds water 1500ml, soaked 30-60 minute, decoct again twice, filter, merge filtrate twice, herb liquid after must decocting is concentrated into 500ml, adds eupolyphaga powder 2g again in the 500ml herb liquid, Hirudo powder 1g and Tabanus powder 1g mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710054427A CN100584370C (en) | 2007-05-18 | 2007-05-18 | The Chinese medicine of control alimentary tract cancer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710054427A CN100584370C (en) | 2007-05-18 | 2007-05-18 | The Chinese medicine of control alimentary tract cancer |
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| CN100584370C true CN100584370C (en) | 2010-01-27 |
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| CN200710054427A Expired - Fee Related CN100584370C (en) | 2007-05-18 | 2007-05-18 | The Chinese medicine of control alimentary tract cancer |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101543612B (en) * | 2009-05-12 | 2012-07-04 | 王秋贤 | Chinese medicament for treating malignant lymphoma |
| CN101584802B (en) * | 2009-06-17 | 2011-06-08 | 李宗宪 | Chinese medicinal capsule for treating malignant lymphoma |
| CN103520651B (en) * | 2013-10-25 | 2015-09-30 | 宋萌颖 | A kind of Chinese medicine composition for the treatment of cervical cancer |
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Non-Patent Citations (2)
| Title |
|---|
| 半夏的中药药理研究进展. 王光明，周蓉.中医药导报，第13卷第2期. 2007 |
| 半夏的中药药理研究进展. 王光明，周蓉.中医药导报，第13卷第2期. 2007 * |
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