CN100581577C - Thrombus diminishing blood-pressure reducing preparation - Google Patents

Abstract

The present invention relates to a Chinese medicine Tongshuan Jiangya preparation for curing apoplexy, hemiplegia, hypertension, facial hemiparalysis, headache diseases. Said Chinese medicine preparation is made up by using 14 Chinese medicinal materials of abalone shell, uncaria stem and thorn, dragon bone, oyster shell, white peony root, ligusticum root, carthamus flower and others through a certain preparation process.

Description

Thrombus diminishing blood-pressure reducing preparation

Technical field

The invention belongs to Chinese herbal and crude drugs preparations technical field, particularly thrombus diminishing blood-pressure reducing preparation.

Background technology

At present, the treatment suffering from acute stroke with blood pressure increase, cranium presses and to increase, Western medicine has 20% mannitol, reserpine, urokinase, Defibrase, troxerutin etc., Chinese medicine preparation also has some Chinese Traditional Medicines.It is no doubt many that Western medicine preparation poison is paid effect, if mismatch treatment by Chinese herbs, delayed the course of disease, and effect is often dissatisfied, and the particularly use of depressor is single with the western medicine antihypertensive effect is fast but action time is short, and rebound phenomenon is arranged after the drug withdrawal.

The inventor has applied for that on April 20th, 1999 name is called the Chinese invention patent of " thrombus diminishing blood-pressure reducing ball ", the patent No. is 99112857.5, this medicine is made of Concha Haliotidis, Os Draconis, Concha Ostreae, the Radix Paeoniae Alba, Radix Ophiopogonis, Rhizoma Gastrodiae, Ramulus Uncariae Cum Uncis etc., acute stage companion blood pressure to apoplexy increases, cranium presses symptoms such as the hemiplegia increase appearance, facial hemiparalysis, dysphonia, headache, nausea and vomiting that obvious curative effects is arranged, and has no side effect.

Summary of the invention

The inventor has passed through big quantity research and test, has adjusted the weight portion ratio of mentioned component and each composition, makes this thrombus diminishing blood-pressure reducing medicine have better therapeutic.

The thrombus diminishing blood-pressure reducing preparation that the purpose of this invention is to provide a kind of better efficacy.

Medicament selection Concha Haliotidis of the present invention, Ramulus Uncariae Cum Uncis, Os Draconis, Concha Ostreae, the Radix Paeoniae Alba, Rhizoma Gastrodiae, Radix Achyranthis Bidentatae, Rhizoma Chuanxiong, Pheretima, Caulis Polygoni Multiflori, Cortex Moutan, Flos Carthami, Scorpio, 14 Chinese medicines of Poria cum Radix Pini make up, make each efficacy of drugs produce synergism these drug regimens, thereby the acute stage companion blood pressure that can effectively treat apoplexy increases, and cranium is pressed symptoms such as the hemiplegia that increases appearance, facial hemiparalysis, dysphonia, headache, nausea and vomiting.

Wherein select Concha Haliotidis to be because Concha Haliotidis has suppressing the hyperactive liver to relieve the wind syndrome, YANG hyperactivity suppressing, and the effect of blood pressure lowering is arranged.Ramulus Uncariae Cum Uncis has the heat clearing away suppressing the hyperactive liver, and endogenous wind stopping is decided the effect of convulsion.Os Draconis have astringing QI by wet, the effect of tranquillizing the mind by relieving convulsion.The Concha Ostreae tranquillization with heavy prescription, the tonifying YIN YANG hyperactivity suppressing, hard masses softening and resolving is restrained astringent or styptic treatment for spontaneous sweating.The Radix Paeoniae Alba, nourishing blood to suppress the hyperactive liver, slow middle pain relieving, yin fluid astringing is received antiperspirant.Rhizoma Gastrodiae, disease such as dizzy, numb limbs and tense tendons of being usually used in having a headache.Radix Achyranthis Bidentatae, bone and muscle strengthening cures mainly cold-damp, the extremity spasm, the lumbago difficulty is stretched, by vim and vigour, blood pressure lowering.Rhizoma Chuanxiong, blood-activating and qi-promoting, wind-expelling pain-stopping.Pheretima is used for Fengshi Guanjie pain, diseases such as hemiplegia.Caulis Polygoni Multiflori nourishes heart, and calms the nerves, and collateral dredging dispels the wind.Cortex Moutan has clearing away heat and cooling blood, the effect of blood circulation promoting competent silt.Flos Carthami, the latus rectum of invigorating blood circulation, eliminating stasis to stop pain.Scorpio, endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.Poria cum Radix Pini has mind calming, the effect of calming the nerves.

The consumption of drug component of the present invention is also groped to sum up to draw through the inventor in a large number, and all medicines share the function with the logical blood dissipating blood stasis collateral dredging blood pressure lowering of tranquillizing and allaying excitement, and each amounts of components is for all to have better curative effect in the following weight parts scope:

Concha Haliotidis 10-30 part, Ramulus Uncariae Cum Uncis 5-25 part, Os Draconis 10-30 part, Concha Ostreae 10-30 part, Radix Paeoniae Alba 10-30 part, Rhizoma Gastrodiae 5-25 part, Radix Achyranthis Bidentatae 5-25 part, Rhizoma Chuanxiong 5-25 part, Pheretima 5-20 part, Caulis Polygoni Multiflori 10-30 part, Cortex Moutan 5-20 part, Flos Carthami 5-20 part, Scorpio 3-6 part, Poria cum Radix Pini 20-40 part.

Medicine of the present invention can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional oral preparations.For example these crude drug pulverize mix homogeneously can be made powder takes after mixing it with water; Can also be with these crude drug decocting together, the condensed water decocting liquid is made concentrated pill routinely then.

Curative effect of medication of the present invention is remarkable, without any side effects, and the acute stage companion blood pressure that is used for the treatment of apoplexy increases, and cranium is pressed symptoms such as the hemiplegia that increases appearance, facial hemiparalysis, dysphonia, headache, nausea and vomiting.

The specific embodiment

[clinical observation]

1, physical data

Accept out-patient's totally 300 examples for medical treatment, wherein male 70 examples, women 230 examples, men and women's ratio is 0.3: 1.Age 20-30 year 10 examples, 31-40 year 50 examples, 41-50 year 80 examples, 160 examples more than 50 years old.

2, examine several standards

One, with reference to " national standard is used tcm internal medicine disease treatment routine "

The ischemia apoplexy refers to go into arteries and veins because of stasis of blood expectorant, blocks due to the brain network.With hemiplegia, dispute is oblique, and hemianopsia, aphasia etc. are main cranial nerve diseases.Be equivalent to the said ischemic cerebrovascular of western medicine.

(1), chronic patient, good sending out in person in middle and old age, the male is more.Dizziness due to wind pathogen is often arranged, brain network numbness, medical history such as quench one's thirst.How under static state such as nighttime sleep or rest, to fall ill.Acute onset person is more common in person between twenty and fifty, and medical histories such as the obstruction of heart-QI, the obstruction of heart-QI, precordial pain with cold limbs, multiple abscess are often arranged, how in physical exertion or morbidity when excited.

(2), before the morbidity, minority has headache premonitory symptom such as dizzy, shows as hemiplegia, hemianopsia, aphasia or aphasia, facial hemiparalysis, sensory disturbance etc. after sick the sending out.Sick the lighter is only clumsy in one's movement, instability of gait, or do not stay sequela for the transience outbreak.General unconscious obstacle, or only of short duration expression is unclear, and stupor is arranged individually.

(3), body temperature, breathing, pulse, blood pressure etc., general do not have obviously change.

(4), the general water white transparency of cerebrospinal fluid, pressure is normal, the ultrasonic body of head is looked into general no center line ripple displacement; CT scan can show low-density infarct.The visible infarct of magnetic resonance.

3, Therapeutic Method

With the concentrated pill is example, oral 3 times of every day, and each 15 grams, two weeks is a course of treatment, 2 courses of treatment of logotype.

4, efficacy assessment standard

Produce effects: transference cure, body language recover better, and headache disappears, and blood pressure life normal range can be taken care of oneself.

Take a turn for the better: sx, body language have recovery in various degree, and headache takes a turn for the better, and blood pressure recovers ideal range.

Invalid: symptom does not have improvement.

5, therapeutic outcome

In a word, 1 middle of the month, with Drug therapy apoplexy 300 examples of the present invention, produce effects 220 examples as a result, 71 examples that take a turn for the better, invalid 9 examples, obvious effective rate 73%, improvement rate 24%, total effective rate 97%.

Come further to set forth the preparation method of medicine of the present invention by the following examples.

[embodiment 1]

20 parts of Concha Haliotidis, 25 parts of Ramulus Uncariae Cum Uncis, 10 parts of Os Draconis, 20 parts of Concha Ostreaes, 10 parts of the Radix Paeoniae Albas, 15 parts in Rhizoma Gastrodiae, 20 parts of Radix Achyranthis Bidentataes, 5 parts of Rhizoma Chuanxiongs, 15 parts of Pheretimas, 10 parts of Caulis Polygoni Multiflori, 20 parts of Cortex Moutans, 10 parts on Flos Carthami, 5 parts of Scorpios, 30 parts of Poria cum Radix Pinis.Pharmaceutical methods is made powder routinely.

[embodiment 2]

10 parts of Concha Haliotidis, 15 parts of Ramulus Uncariae Cum Uncis, 20 parts of Os Draconis, 10 parts of Concha Ostreaes, 20 parts of the Radix Paeoniae Albas, 5 parts in Rhizoma Gastrodiae, 25 parts of Radix Achyranthis Bidentataes, 15 parts of Rhizoma Chuanxiongs, 20 parts of Pheretimas, 20 parts of Caulis Polygoni Multiflori, 10 parts of Cortex Moutans, 20 parts on Flos Carthami, 6 parts of Scorpios, 40 parts of Poria cum Radix Pinis.Pharmaceutical methods is made oral liquid routinely.

[embodiment 3]

30 parts of Concha Haliotidis, 5 parts of Ramulus Uncariae Cum Uncis, 30 parts of Os Draconis, 30 parts of Concha Ostreaes, 30 parts of the Radix Paeoniae Albas, 25 parts in Rhizoma Gastrodiae, 5 parts of Radix Achyranthis Bidentataes, 25 parts of Rhizoma Chuanxiongs, 5 parts of Pheretimas, 30 parts of Caulis Polygoni Multiflori, 5 parts of Cortex Moutans, 5 parts on Flos Carthami, 3 parts of Scorpios, 20 parts of Poria cum Radix Pinis.

Pharmaceutical methods is made concentrated pill routinely.

Claims (1)

1, a kind of thrombus diminishing blood-pressure reducing preparation is characterized in that it is to be made by the raw material medicaments in part by weight ratio of following compositions: Concha Haliotidis 10-30 part, Ramulus Uncariae Cum Uncis 5-25 part, Os Draconis 10-30 part, Concha Ostreae 10-30 part, Radix Paeoniae Alba 10-30 part, Rhizoma Gastrodiae 5-25 part, Radix Achyranthis Bidentatae 5-25 part, Rhizoma Chuanxiong 5-25 part, Pheretima 5-20 part, Caulis Polygoni Multiflori 10-30 part, Cortex Moutan 5-20 part, Flos Carthami 5-20 part, Scorpio 3-6 part, Poria cum Radix Pini 20-40 part.