CN100569263C - A kind of pharmaceutical composition for the treatment of stomachache and preparation method thereof - Google Patents
A kind of pharmaceutical composition for the treatment of stomachache and preparation method thereof Download PDFInfo
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- CN100569263C CN100569263C CNB2007101768973A CN200710176897A CN100569263C CN 100569263 C CN100569263 C CN 100569263C CN B2007101768973 A CNB2007101768973 A CN B2007101768973A CN 200710176897 A CN200710176897 A CN 200710176897A CN 100569263 C CN100569263 C CN 100569263C
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Abstract
The invention discloses a kind of pharmaceutical composition bavin trifoliate orange summer for the treatment of stomachache connects capsule, and it is mainly made by ten kinds of Chinese medicines such as Radix Bupleuri, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparata, Pericarpium Citri Reticulatae, Rhizoma Coptidis, Rhizoma Cyperi, Rhizoma Corydalis, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae.Pharmaceutical composition dispersing the stagnated liver-QI for regulating the stomach of the present invention is used for gastral cavilty distending pain due to the incoordination between the liver and stomach, belch, noisy pantothenic acid, dry mouth with bitter taste etc., and chronic gastritis, the acute activeness inflammation of gastric mucosa, bile reflux is seen above-mentioned patient, the cure rate height, relapse rate is low, is with a wide range of applications.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition bavin trifoliate orange summer for the treatment of stomachache connects capsule, belongs to the technical field of pharmaceuticals for the treatment of gastropathy.Be used for the treatment of gastral cavilty distending pain due to the incoordination between the liver and stomach, belch, noisy pantothenic acid, dry mouth with bitter taste etc., and chronic gastritis, the acute activeness inflammation of gastric mucosa, bile reflux etc.
Background technology
The gastric abscess of Chinese medicine is a kind of common disease, its etiology and pathogenesis complexity, and syndrome feature difference has multiple differentiation of symptoms and signs for classification of syndrome, and representational have incoordination between the liver and stomach, deficiency of spleen-QI and stomach-QI, a deficiency of stomach-Yin etc.Stomachache is meant stagnation of QI impairing the liver due to the incoordination between the liver and stomach, and edema with the liver involved can not catharsis, and perverse and unreasonable manner is violated stomach and the pain that takes place, how shows effect because of feelings will inducement such as do not relax, and disease is seen: gastral cavilty distending pain, belch, noisy pantothenic acid, dry mouth with bitter taste etc.The chronic gastritis that comprises modern medicine, the acute activeness inflammation of gastric mucosa, bile reflux etc.The stomachache patient is onset and influence study and work due to illness often, the medicine of multiple this type of disease of treatment is arranged in the market, but effect is unsatisfactory.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine for the treatment of the incoordination between the liver and stomach gastric abscess.That this Chinese medicine has is evident in efficacy, short treating period, take characteristics such as send out just, side effect is little.
The present invention also provides this preparation method of Chinese medicine.
Pharmaceutical composition of the present invention can be used for treating gastral cavilty distending pain due to the incoordination between the liver and stomach, belch, noisy pantothenic acid, dry mouth with bitter taste etc., and chronic gastritis, the acute activeness inflammation of gastric mucosa, bile reflux etc.
Chinese medicine of the present invention is prepared from by the following weight parts proportion raw material:
10～20 parts of 8～20 parts of Rhizoma Pinelliae Preparata of 10～30 parts of Fructus Aurantii Immaturuss of 10～30 portions of Radix Paeoniae Albas of Radix Bupleuri
10～30 parts of 8～20 parts of Rhizoma Corydalis of 5～10 portions of Rhizoma Cyperis of 8～20 portions of Rhizoma Coptidis of Pericarpium Citri Reticulatae
5～10 parts of 10～30 parts of Radix Glycyrrhizae of Radix Salviae Miltiorrhizae
Chinese medicine of the present invention is prepared from by following optimum raw materials in weight portion:
10～15 parts of 8～15 parts of Rhizoma Pinelliae Preparata of 10～20 parts of Fructus Aurantii Immaturuss of 10～20 portions of Radix Paeoniae Albas of Radix Bupleuri
10～20 parts of 8～15 parts of Rhizoma Corydalis of 5～8 portions of Rhizoma Cyperis of 8～15 portions of Rhizoma Coptidis of Pericarpium Citri Reticulatae
5～8 parts of 10～20 parts of Radix Glycyrrhizae of Radix Salviae Miltiorrhizae
Chinese medicine of the present invention is prepared from by following optimum weight part proportion raw material:
6 parts of 10 portions of Rhizoma Coptidis of 15 parts of Pericarpium Citri Reticulataes of 10 parts of Rhizoma Pinelliae Preparata of 15 parts of Fructus Aurantii Immaturuss of 15 portions of Radix Paeoniae Albas of Radix Bupleuri
6 parts of 15 parts of Radix Glycyrrhizae of 15 parts of Radix Salviae Miltiorrhizaes of 10 parts of Rhizoma Corydalis of Rhizoma Cyperi.
Chinese medicine of the present invention can be prepared from by following method:
1, get Pericarpium Citri Reticulatae, Rhizoma Cyperi two flavors, extract volatile oil, standby.
2, Pericarpium Citri Reticulatae, Rhizoma Cyperi medicinal residues and Radix Bupleuri, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, the Rhizoma Pinelliae, Radix Glycyrrhizae are decocted with water twice, 0.5～4 hour for the first time, 0.5～3 hour for the second time.
3, merge twice decocting liquid, filter, concentrate.
4, Rhizoma Coptidis, Rhizoma Corydalis, Radix Salviae Miltiorrhizae powder are broken into coarse powder, use 60% ethanol percolation.
5,3,4 medicinal liquids are merged, concentrate, spray drying sprays into volatile oil, encapsulated forming.
Wherein said Radix Bupleuri is the dry root of umbelliferae bupleurum Bupleurum chinense DC..Main product in Jilin, ground such as Liaoning, Hebei, be good with Radix Bupleuri.
The Radix Paeoniae Alba is the dry root of cohosh Radix Paeoniae Paeonia lactiflora Pall..Main product in Zhejiang, ground such as Sichuan, Anhui.
Fructus Aurantii Immaturus is the young fruit of rutaceae Citrus aurantium Linn. Citrus aurantium L..Ground such as main product Sichuan, Jiangxi.With Fructus Aurantii Immaturus (parched with bran) is good.
The Rhizoma Pinelliae is the tuber of aroid Rhizoma Pinelliae Pinellia tuberifera tenore.Main product in Sichuan, ground such as Hubei, Henan, Guizhou, Anhui.With Rhizoma Pinelliae Preparata is good.
Pericarpium Citri Reticulatae is the dry mature skin of rutaceae orange Citrus reticulata Blanco and variety thereof.Main product in Guangdong, ground such as Guangxi, Fujian, Jiangxi.
Rhizoma Coptidis is ranunculaceae plant Rhizoma Coptidis Coptis chinensis Franch, the dry rhizome of Coptis deltoidea C.Y.Cheng et Hsiao Coptis deltoideaC.Y.Cheng et Hsiao.Main product is in Sichuan, Hubei and other places.Be linked as good with chicken feet.
Rhizoma Cyperi is the dry rhizome of sedge dried tuber Cyperus rotundus L..Main product in Shandong, ground such as Zhejiang, Fujian, Hunan.With Rhizoma Cyperi (processed with vinegar) is good.
Rhizoma Corydalis is the dry tuber of papaveraceae plant corydalis Corydalis yanhusuo W.T.Wang.Main product is in Zhejiang, ground such as Jiangsu, Shandong.With the vinegar Rhizoma Corydalis is good.
Radix Salviae Miltiorrhizae is the dry root and rhizome of labiate Radix Salviae Miltiorrhizae Salvia Miltiorrhiza Bge..Main product in Sichuan, ground such as Shanxi, Hebei, Jiangsu, Anhui.
Radix Glycyrrhizae is the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch..Main product is in the Inner Mongol, Gansu and other places.With Radix Glycyrrhizae is good.
Radix Bupleuri, the Radix Paeoniae Alba are monarch in the prescription of the present invention.Radix Bupleuri, Radix Paeoniae Alba hardship, suffering, be slightly cold, go into the liver and gall warp, can the dispersing the stagnated live-QI to relieve the stagnation of QI heat clearing away." book on Chinese herbal medicine justice " cloud: " liver and gall wood is strongly fragrant, and perverse and unreasonable manner is for suffering from, and is that the ascension catharsis person with Radix Bupleuri controls it." " book on Chinese herbal medicine is through hundred tunnel records ": " Radix Bupleuri, the medicine of the intestines and stomach is also." so use the Radix Bupleuri dispersing the stagnated live-QI to relieve the stagnation of QI, right liver body is cloudy and with sun, also need cloudy medicine Radix Paeoniae Alba cooperation with Radix Bupleuri.The Radix Paeoniae Alba yin fluid astringing that nourishes blood, the nourishing the liver pain relieving.The Radix Bupleuri and the Radix Paeoniae Alba are shared, and body and function is taken into account, and the power of dispersing the stagnated live-QI to relieve the stagnation of QI is stronger.The flat then all diseases of liver all disappear, so be monarch with this two medicine.
Rhizoma Cyperi suffering, sweet, little hardship, flat are gone into Liver Channel, and the resolving depression pain relieving of regulating the flow of vital energy cures mainly incoordination between the liver and stomach, feeling of fullness uncomfortable in chest etc." the southern regions of the Yunnan Province book on Chinese herbal medicine " cloud: " dissipating depression of QI gas and transfer all gas.Alleviating distention in middle-JIAO helps digestion, and preventing or arresting vomiting is told and middle nourishing the stomach." " book on Chinese herbal medicine converges and says ": " the philanthropist trusted subordinate is pain, gathers pent-up, feeling of fullness." so help Radix Bupleuri, the pain relieving of Radix Paeoniae Alba dispersing the stagnated live-QI to relieve the stagnation of QI and be ministerial drug with Rhizoma Cyperi.Rhizoma Pinelliae Preparata suffering, temperature are gone into spleen, stomach warp, dissolving lump and resolving mass, and it is vexed to cure mainly breast gastral cavity painful abdominal mass." property of medicine opinion " cloud Rhizoma Pinelliae can " preventing or arresting vomiting be told for expectorant saliva, appetite promoting and the spleen strengthening, goes in the heart expectorant full, following lung qi, the main knot of coughing ".The Radix Salviae Miltiorrhizae hardship, be slightly cold, go into the heart, Liver Channel, promoting blood circulation to disperse blood clots and relieves pain.Rhizoma Coptidis hardship, cold is returned spleen, stomach, liver, gallbladder meridian.Because of the strongly fragrant heat-transformation of liver stomach, " all contrary rushing to all belong to fire, and all vomiting acid all belongs to hot " is so be ministerial drug with Rhizoma Coptidis heat clearing away sending down the abnormal ascending QI.
The Fructus Aurantii Immaturus dispelling the stagnated QI painful abdominal mass of loosing, the Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen.The two can strengthen the merit of Radix Bupleuri depressed liver-energy dispersing and QI regulating.Rhizoma Corydalis suffering, hardship, temperature are gone into liver, spleen channel, the blood-activating and qi-promoting pain relieving.Three medicines share and are adjuvant drug.The Radix Glycyrrhizae relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription is for making.
This side's compatibility is reasonable, and flavour of a drug are proper, and all medicines gather dispersing the stagnated liver-QI for regulating the stomach altogether, the merit of regulating QI to relieve pain.
Clinical observation shows that connecting the capsule for treating gastric abscess with the bavin trifoliate orange summer belongs to incoordination between the liver and stomach person's 60 examples, total effective rate 93.33%, and cure rate reaches 71.67%.Do blood, urine, just routine and hepatic and renal function inspection before and after the treatment, no abnormality seen changes, and does not find in the medication process that this medicine has tangible untoward reaction.It is evident in efficacy that test shows that the bavin trifoliate orange summer connects the capsule for treating stomachache, and onset is very fast, has no side effect.
The specific embodiment
Embodiment 1:
Radix Bupleuri 150g Radix Paeoniae Alba 150g Fructus Aurantii Immaturus 100g Rhizoma Pinelliae Preparata 150g Pericarpium Citri Reticulatae 100g Rhizoma Coptidis 60g
Rhizoma Cyperi 100g Rhizoma Corydalis 150g Radix Salviae Miltiorrhizae 150g Radix Glycyrrhizae 60g
Get Pericarpium Citri Reticulatae, Rhizoma Cyperi two flavors, extract volatile oil, standby.Medicinal residues and Radix Bupleuri, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, the Rhizoma Pinelliae, Radix Glycyrrhizae decoct with water twice, and 0.5～4 hour for the first time, 0.5～3 hour for the second time.Merge twice decocting liquid, filter, concentrate.Rhizoma Coptidis, Rhizoma Corydalis, Radix Salviae Miltiorrhizae powder are broken into coarse powder, use 60% ethanol percolation.Medicinal liquid is merged, concentrate, spray drying sprays into volatile oil, encapsulated forming, every capsules 0.5g.
Embodiment 2:
Radix Bupleuri 100g Radix Paeoniae Alba 100g Fructus Aurantii Immaturus 80g Rhizoma Pinelliae Preparata 100g Pericarpium Citri Reticulatae 80g Rhizoma Coptidis 50g
Rhizoma Cyperi 80g Rhizoma Corydalis 100g Radix Salviae Miltiorrhizae 100g Radix Glycyrrhizae 50g
Get Pericarpium Citri Reticulatae, Rhizoma Cyperi two flavors, extract volatile oil, standby.Medicinal residues and Radix Bupleuri, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, the Rhizoma Pinelliae, Radix Glycyrrhizae decoct with water twice, and 0.5～4 hour for the first time, 0.5～3 hour for the second time.Merge twice decocting liquid, filter, concentrate.Rhizoma Coptidis, Rhizoma Corydalis, Radix Salviae Miltiorrhizae powder are broken into coarse powder, use 60% ethanol percolation.Medicinal liquid is merged, concentrate, spray drying sprays into volatile oil, encapsulated forming, every capsules 0.5g.
Embodiment 3:
Radix Bupleuri 200g Radix Paeoniae Alba 200g Fructus Aurantii Immaturus 150g Rhizoma Pinelliae Preparata 200g Pericarpium Citri Reticulatae 150g Rhizoma Coptidis 80g
Rhizoma Cyperi 150g Rhizoma Corydalis 200g Radix Salviae Miltiorrhizae 200g Radix Glycyrrhizae 80g
Get Pericarpium Citri Reticulatae, Rhizoma Cyperi two flavors, extract volatile oil, standby.Medicinal residues and Radix Bupleuri, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, the Rhizoma Pinelliae, Radix Glycyrrhizae decoct with water twice, and 0.5～4 hour for the first time, 0.5～3 hour for the second time.Merge twice decocting liquid, filter, concentrate.Rhizoma Coptidis, Rhizoma Corydalis, Radix Salviae Miltiorrhizae powder are broken into coarse powder, use 60% ethanol percolation.Medicinal liquid is merged, concentrate, spray drying sprays into volatile oil, encapsulated forming, every capsules 0.5g.
Claims (4)
1, a kind of pharmaceutical composition of having a stomachache due to the incoordination between the liver and stomach for the treatment of, it is characterized in that forming: 10～30 parts of Radix Bupleuri by the feedstock production of following weight portion, 10～30 parts of the Radix Paeoniae Albas, 8～20 parts of Fructus Aurantii Immaturuss, 10～20 parts of Rhizoma Pinelliae Preparata, 8～20 parts of Pericarpium Citri Reticulataes, 5～10 parts of Rhizoma Coptidis, 8～20 parts of Rhizoma Cyperis, 10～30 parts of Rhizoma Corydalis, 10～30 parts of Radix Salviae Miltiorrhizaes, 5～10 parts of Radix Glycyrrhizae.
2, according to the described a kind of pharmaceutical composition of having a stomachache due to the incoordination between the liver and stomach for the treatment of of claim 1, it is characterized in that forming: 10～20 parts of Radix Bupleuri by the feedstock production of following weight portion, 10～20 parts of the Radix Paeoniae Albas, 8～15 parts of Fructus Aurantii Immaturuss, 10～15 parts of Rhizoma Pinelliae Preparata, 8～15 parts of Pericarpium Citri Reticulataes, 5～8 parts of Rhizoma Coptidis, 8～15 parts of Rhizoma Cyperis, 10～20 parts of Rhizoma Corydalis, 10～20 parts of Radix Salviae Miltiorrhizaes, 5～8 parts of Radix Glycyrrhizae.
3, according to the pharmaceutical composition of having a stomachache due to claim 1 or the 2 described treatment incoordination between the liver and stomach, it is characterized in that the optimised quantity of each raw material is: 15 parts of Radix Bupleuri, 15 parts of the Radix Paeoniae Albas, 10 parts of Fructus Aurantii Immaturuss, 15 parts of Rhizoma Pinelliae Preparata, 10 parts of Pericarpium Citri Reticulataes, 6 parts of Rhizoma Coptidis, 10 parts of Rhizoma Cyperis, 15 parts of Rhizoma Corydalis, 15 parts of Radix Salviae Miltiorrhizaes, 6 parts of Radix Glycyrrhizae.
4, pharmaceutical composition according to claim 3 extracts volatile oil with Pericarpium Citri Reticulatae, Rhizoma Cyperi, and medicinal residues and Radix Bupleuri, the Radix Paeoniae Alba, Fructus Aurantii Immaturus, Rhizoma Pinelliae Preparata, Radix Glycyrrhizae decoct with water twice, and collecting decoction concentrates; Rhizoma Coptidis, Rhizoma Corydalis, Radix Salviae Miltiorrhizae powder are broken into coarse powder, use 60% ethanol percolation, and above-mentioned medicinal liquid merges, and concentrate, and spray drying sprays into volatile oil, encapsulated forming, every capsules 0.5g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CNB2007101768973A CN100569263C (en) | 2007-11-07 | 2007-11-07 | A kind of pharmaceutical composition for the treatment of stomachache and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CNB2007101768973A CN100569263C (en) | 2007-11-07 | 2007-11-07 | A kind of pharmaceutical composition for the treatment of stomachache and preparation method thereof |
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| CN100569263C true CN100569263C (en) | 2009-12-16 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101099004B1 (en) * | 2009-03-13 | 2011-12-28 | 주식회사 사이그린 | A composition for preventing or treating a gastrointestinal disease |
| CN104623504A (en) * | 2015-02-11 | 2015-05-20 | 刘连强 | Traditional Chinese medicine composition for treating liver-stomach disharmony |
| CN105169179A (en) * | 2015-09-18 | 2015-12-23 | 马鞍山德宏堂生物科技有限公司 | Traditional Chinese medicine composition for treating epigastric pain |
| CN106237192A (en) * | 2016-10-31 | 2016-12-21 | 张元鸿 | A kind of for compound medicine treating stomachache and preparation method thereof |
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2007
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Non-Patent Citations (4)
| Title |
|---|
| 胃脘痛中医药治疗近况. 刘锐，胡穗发.时珍国医国药，第15卷第（12）期. 2004 |
| 胃脘痛中医药治疗近况. 刘锐，胡穗发.时珍国医国药，第15卷第（12）期. 2004 * |
| 胃脘痛治疗研究近况. 屠顶荣.安徽中医学院学报，第14卷第（2）期. 1995 |
| 胃脘痛治疗研究近况. 屠顶荣.安徽中医学院学报，第14卷第（2）期. 1995 * |
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