CN100569233C - Can prevent the compositions of carcinoma of prostate - Google Patents
Can prevent the compositions of carcinoma of prostate Download PDFInfo
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- CN100569233C CN100569233C CNB2008100337471A CN200810033747A CN100569233C CN 100569233 C CN100569233 C CN 100569233C CN B2008100337471 A CNB2008100337471 A CN B2008100337471A CN 200810033747 A CN200810033747 A CN 200810033747A CN 100569233 C CN100569233 C CN 100569233C
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Abstract
The present invention relates to a kind of compositions of preventing carcinoma of prostate, the effective ingredient of said composition is by lycopene, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B12, vitamin C, caffeine, epicatechin, L-Epicatechin gallate, epigallo catechin, epigallocatechin gallate (EGCG), Quercetin, form with vitamin E, its advantage is, to the tangible prevention of having of carcinoma of prostate, the effect that reverses or delay, can reduce the sickness rate of cancer.
Description
Technical field
The present invention relates to a kind of compositions of preventing carcinoma of prostate.
Background technology
Some natural chemical substance is to the effect that prevention is arranged, reverse or delay of cancer, can reduce the sickness rate of cancer by this effect, reduces high-risk group and low danger crowd's cancer prevalence and case fatality rate, and improves the quality of living.Chemoprophylacticly successfully depend at molecule, cell and organize on the level understanding carcinogenesis mechanism.Cancer be a multistage, multi-path and multifocal process, whole process comprises the change of a series of epigenetics and hereditism aspect, these changes result from genomic instability and finally caused the generation of tumor.On molecular level, this process comprises the afunction of oncogene active, antioncogene, and with relevant gene alterations such as growth regulating, cell cycle, apoptosis, neoplasm metastasis, blood vessel generation, also have modifying gene change (these genes with the carcinogen metabolism, methylate, the DNA reparation is relevant with genome stability).At cell and organizing on the level, the change of successive gene and molecule has caused gradually from normally to the change of in various degree growth disdifferentiation, this process often needs more than several years even decades, becomes the tumor with aggressive and transfer ability until last differentiation.The process of this secular complexity makes tumor initial sum last stage of cancerating carry out clinical interventional therapy and become possibility.The chemoprophylaxis strategy of people's first-selection is the commitment that takes place in cancer, uses natural or synthetic medicine delays, stops or even reverse cancer process.
Because carcinoma of prostate sickness rate height, popular wide, incubation period long, the case fatality rate height of disease association and living habit and environmental factors play a crucial role in disease etc. these characteristics are so carcinoma of prostate is suitable for prevention.The chemoprophylaxis of carcinoma of prostate is no matter medically and economically can both play tremendous influence.
The chemoprophylaxis of carcinoma of prostate also is in the commitment of development at present, but people have recognized the problem that only exists toxicity and effectiveness aspect by the prevention of single medicine.And unite use by a plurality of natural drugs that the different mechanism of action is arranged is the new highlight of studying at present.
Summary of the invention
The objective of the invention is according to above-mentioned the deficiencies in the prior art part, a kind of compositions of preventing carcinoma of prostate is provided, said composition constitutes stable compositions more after with lycopene, green tea extract, Quercetin and vitamin B, C, E combination, and utilizes each component synergism each other wherein to reach anti-cancer, anticancer effect.
The object of the invention realizes being finished by following technical scheme:
A kind of compositions of preventing carcinoma of prostate, the effective ingredient that it is characterized in that said composition is made up of lycopene, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B12, vitamin C, caffeine, epicatechin, L-Epicatechin gallate, epigallo catechin, epigallocatechin gallate (EGCG), Quercetin and vitamin E.
In the effective ingredient of said composition, the shared percentage ratio of lycopene is no less than 1.4%.
In the effective ingredient of said composition, the shared percentage ratio of vitamin B1 is no less than 0.3%; The shared percentage ratio of vitamin B2 is no less than 0.4; The shared percentage ratio of vitamin B3 is no less than 2.4%; The shared percentage ratio of vitamin B6 is no less than 0.5%; The shared percentage ratio of vitamin B12 is no less than 0.0015%; The shared percentage ratio of vitamin C is no less than 12.2%; Vitamin E is no less than 1.8%.
In the effective ingredient of said composition, the shared percentage ratio of caffeine is no less than 10.5%.
In the effective ingredient of said composition, the shared percentage ratio of the compositions of epicatechin, L-Epicatechin gallate, epigallo catechin and epigallocatechin gallate (EGCG) is no less than 20.1%.
In the effective ingredient of said composition, the shared percentage ratio of Quercetin is no less than 6.1%.
The shared percentage ratio of each component is respectively in the effective ingredient of said composition: lycopene is 1.4%-2.7%; Vitamin B1 is 0.3%-0.5%; Vitamin B2 is 0.4%-1.7%; Vitamin B3 is 2.4%-7.5%; Vitamin B6 is 0.5%-1.5%; Vitamin B12 is 0.0015%-0.003%; Vitamin C is 12.2%-18.5%; Coffee is because 10.5%-22.5%; The combined amount of epicatechin, L-Epicatechin gallate, epigallo catechin and epigallocatechin gallate (EGCG) is 20.1%-43.5%; Quercetin is 6.1%-28.8%; Vitamin E is 1.8%-18.6%.
The effective dose of described compositions is 800-5600 milligram every day.
Contain sweetener or aminoacid or mineral or flavoring agent or pigment or above-mentioned at least two kinds combination in the said composition.
The form of said composition is liquid, semi liquid state or solid-state.
A kind of composition manufacturing method of preventing carcinoma of prostate, it is characterized in that the green tea extract at first selecting a certain amount of Fructus Lycopersici esculenti, Fructus actinidiae chinensis, Fructus Mali pumilae and green tea or contain caffeine, epicatechin, L-Epicatechin gallate, epigallo catechin and epigallocatechin gallate (EGCG), after pulverizing, stir, mixing, carry out heat treated, stir the formation stable composition at last once more.
A certain amount of will making in described a certain amount of Fructus Lycopersici esculenti, Fructus actinidiae chinensis, Fructus Mali pumilae and the green tea contained following chemical compound in the compositions, and is 100 parts in the summation of following each chemical compound: lycopene wherein is no less than 1.4%; Vitamin B1 is no less than 0.3%; Vitamin B2 is no less than 0.4; Vitamin B3 is no less than 2.4%; Vitamin B6 is no less than 0.5%; Vitamin B12 is no less than 0.0015%; Vitamin C is no less than 12.2%; Caffeine is no less than 10.5%; The compositions of epicatechin, L-Epicatechin gallate, epigallo catechin and epigallocatechin gallate (EGCG) is no less than 20.1%; Quercetin is no less than 6.1%; Vitamin E is no less than 1.8%.
Advantage of the present invention is, to the tangible prevention of having of carcinoma of prostate, the effect that reverses or delay, can reduce the sickness rate of cancer.
Concrete technical scheme
By the following examples feature of the present invention and other correlated characteristic are described in further detail, so that technical staff's of the same trade understanding:
Embodiments of the invention are in the middle of concrete the application, what of various compositions are according to the difference of user concrete condition in its compositions, the reference consumption of its every day is usually in following interval range: lycopene is 3-150mg, vitamin B1 is 0.1-50mg, vitamin B2 is 0.1-150mg, vitamin B3 is 0.1-2000mg, vitamin B6 is 0.1-200mg, vitamin B12 is 5-150 μ g, vitamin C is 30-2000mg, coffee is because of 30-1500mg, and epicatechin is 10-500mg, and L-Epicatechin gallate is 10-500mg, epigallo catechin is 10-500mg, epigallocatechin gallate (EGCG) is 10-500mg, and Quercetin is that 20-2000mg and vitamin E are 3-1000IU.The wherein more satisfactory range of choice is that lycopene is 15-150mg, vitamin B1 is 2-30mg, vitamin B2 is 3-100mg, vitamin B3 is 10-1500mg, vitamin B6 is 4-150mg, vitamin B12 is 10-100 μ g, vitamin C is 30-1500mg, coffee is because 30-500mg, epicatechin is 30-400mg, L-Epicatechin gallate is 30-450mg, and epigallo catechin is 30-450mg, and epigallocatechin gallate (EGCG) is 20-500mg, Quercetin is 30-1800mg, vitamin E is 10-900IU, with dissolving after the combination of the chemical compound of above-mentioned weight or being suspended from aqueous solution such as the cosolvent of ethanol (contain) of 1 liter, perhaps makes powder, capsule, tablet, similar type such as unguentum.Why more wide in range the selection interval of above-mentioned each chemical compound is, and reason is the effect of the existing prevention of the present invention, and the effect of treatment is also arranged, at use crowd simultaneously, and the difference of body constitution is also bigger.
Above-mentioned Quercetin refers to quercetin glycoside and quercetin derivative, as Quercetin-3-oxygen glucosides, Quercetin-5-oxygen glucosides, Quercetin-7-oxygen glucosides, Quercetin-9-oxygen glucosides, Quercetin-3-oxygen rutinoside, Quercetin-3-oxygen galactoside, Quercetin-7-oxygen galactoside and Quercetin-3-oxygen rhamnoside.Postdigestive quercetin derivative is converted into quercetin glycoside, and the latter is the activity form that can be absorbed by the body.Obviously can also add sweetener such as sucrose in the present embodiment product, high-fructose corn syrup and analog, and aminoacid, mineral, flavoring agent, pigment or the like.
When present embodiment is made powder, can be used for the preparation of beverage (as tea and fruit juice) easily.Can also be used to being prepared into paste, gluey agent, capsule or tablet.Lactose and starch generally are used as the carrier of capsular diluent and tablet, make the lubricant that often adds in the process as magnesium stearate and so at tablet.
The present embodiment product both can be used as food additive, can also be directly as pharmaceutical preparation.During as food additive, can also add extra nutrient, as mineral or aminoacid etc., its mixture can be solid-state (as powder, capsule or tablet), also can be liquid (as beverage or syrup).It can be beverage or a kind of food, such as tea (as tea beverage and bag bag tea), soft drink, fruit juice (squeezing the juice and fruit drink as fruit), milk, coffee, cake, cookies, expanded class cereal foods, chocolate, all kinds of snacks or the like.Facts have proved that the present embodiment product exists with above-mentioned any form, can prevent, reverses or delay the process of carcinoma of prostate.
Caffeine in the present embodiment, epicatechin, L-Epicatechin gallate, epigallo catechin, epigallocatechin gallate (EGCG) can derive from green tea extract.
Specific embodiment is as follows:
Embodiment 1:
Select 60mg lycopene, 20mg vitamin B1,65mg vitamin B2,300mg vitamin B3,60mg vitamin B6,100 μ g vitamin B1ies, 500mg vitamin C, 800mg quercetin glycoside, vitamin E (750IU), and caffeine 500mg, the epicatechin 150mg, L-Epicatechin gallate 350mg, epigallo catechin 350mg, the epigallocatechin gallate (EGCG) 130mg that derive from green tea extract, add 500mL water, use agitator vigorous stirring compositions then, be diluted with water to 1 liter again and get final product.
Embodiment 2:
Select 15mg lycopene, 2.5mg vitamin B1,3.5mg vitamin B2,40mg vitamin B3,4.5mg vitamin B6,15 μ g vitamin B1ies, 150mg vitamin C, 50mg quercetin glycoside, 18mg caffeine, 54mg epicatechin, 126mg L-Epicatechin gallate, 126mg epigallo catechin, 47mg epigallocatechin gallate (EGCG), and 15IU vitamin E, the Sucus Mali pumilae that adds 500mL water and 100ml, with blender vigorous stirring compositions, be diluted with water to 1 liter again and get final product.
Embodiment 3:
Select 150mg lycopene, 25mg vitamin B1,70mg vitamin B2,350mg vitamin B3,60mg vitamin B6,120 μ g vitamin B1ies, 800mg vitamin C, 1600mg quercetin glycoside, 600mg caffeine, 180mg epicatechin, 390mg L-Epicatechin gallate, 390mg epigallo catechin, 160mg epigallocatechin gallate (EGCG), and 800IU vitamin E, add 500mL water, use agitator vigorous stirring compositions then, be diluted with water to 1 liter again and get final product.
Embodiment 4:
Present embodiment is with natural prodcuts, comprises the compositions that Fructus Lycopersici esculenti, Fructus actinidiae chinensis, Fructus Mali pumilae and green tea are formed.
1g green tea, 510g Fructus Lycopersici esculenti, 120g Fructus actinidiae chinensis and 155g Fructus Mali pumilae are joined in the agitator, the mixture vigorous stirring is ground into dense condensed liquid, liquid heat to 86 ℃, kept 15 minutes afterwards, add 10g sugar and 92g ice cube vigorous stirring once more again, can directly drink.
Tumor be a multistage process, any carcinogen in the environment (as smoking, industrial discharge, vehicle exhaust), pro-inflammatory cytokine (as tumor necrosis factor and hydrogen peroxide), and tumor promoter can both cause the generation of tumor.These carcinogens are considered to change transcription factor (as nuclear factor NF-κ B), activator protein-1 (AP-1), signal transduction and transcription activator 3 (STAT-3), anti-apoptotic proteins (as Akt, Bcl-2, Bcl-X
L), proapoptotic protein is (as caspase, polyadenous glycosides 5 '-bis phosphoric acid ribose polymerase (PARP), protein kinase (as I κ-B alpha kinase (IKK)), EGF-R ELISA (EGFR), human epidermal growth factor acceptor 2 (HER2), c Jun N holds kinases (JNK), cell mitogen activated protein kinase (MAKP), cyclin is (as cyclin (cyclins), cyclin dependent kinase (cyclin-dependent kinases)), cell adhesion molecule, cyclooxygenase 2 (COX-2), the growth factor signal path.
The synergism of each component provides wide probability for each control of cancer and the prevention of carcinoma of prostate in stage in the present composition, coordinative role between each component has suppressed the inflammation process, this inflammatory process can cause tumor, the conversion, the high value-added that cause tumor, therefore their this inhibitory action has finally also suppressed the tumor in late period, i.e. angiogenic growth and transfer.Summarized effective synergism of each targeted molecular level of individual channel in Table 1.
Table one
The evidence present composition is to the 2-amino-1-methyl-6-phenylimidazole (4 of mutagenicity, 5-b) pyridine (PhIP) has inhibitory action, PhIP is a kind of composition that is present in the diet, be present in the Carnis Sus domestica or fish that boils, just as much be present in the carcinogenic heterocyclic aromatic amine in smoke condensate and the diesel exhaust.
Fruits and vegetables not only contains abundant cellulose, vitamin and mineral, also contains the composition that polyphenol, terpenes, alkaloids, phenolic compound etc. can produce potential benefit to health.
Lycopene is a very powerful antioxidant, abundant being present in the various goods of Fructus Lycopersici esculenti and Fructus Lycopersici esculenti.Discover that lycopene helps to reduce the generation of some tumors.Its effect is more obvious to the early stage effect of carcinoma of prostate.In the research of a carcinoma of prostate, scientists study the level of lycopene in blood, and find the particularly sickness rate of invasive tumor of carcinoma of prostate, reduce along with the increasing of lycopene levels in the blood.
Quercetin is a kind of Flavonoid substances, and the occurring in nature ubiquity just has in the Fructus Mali pumilae.It can interact, suppress effects such as tyrosine kinase by the adjusting cell cycle, with two type estrogen action sites, becomes a very potential cancer-resisting substance.A lot of vitro datas and preliminary animal and human's tables of data understands that Quercetin suppresses tumor growth.
Polyphenols has been represented the active antioxidant composition of the class in the green tea.Contain four kinds of main catechins in the leaf of known green tea, epicatechin, L-Epicatechin gallate, epigallo catechin, epigallocatechin gallate (EGCG).So these compositions can obtain from extract from green tea easily.Epidemic data shows that green tea consumption is many more, and the prevalence of the tumor at multiple position is just low more.The consumption of green tea and gastric cancer, the morbidity of the esophageal carcinoma, pulmonary carcinoma, cancer of pancreas, colon cancer and rectal cancer becomes negative correlation.Certain research finds that also these compositions in the green tea can be blocked the gastric cancer in excessive phase and late period.
As many fruit and vegetables, Fructus Mali pumilae, Fructus actinidiae chinensis and Fructus Lycopersici esculenti have been rich in vitamin C and many other antioxidant compositions, and these materials can both reduce the incidence rate of cancer by stoping DNA damage.The phenolic compound that external evidence suggests, Fructus Mali pumilae are contained can be anticancer, and this has shown that also it has non-oxidizability.Main phenols chemical substance in the Fructus Mali pumilae is Quercetin, epicatechin and procyanidin B 2.Fructus actinidiae chinensis has been rich in vitamin C, polyphenol, Flavonoid substances, vitamin E, magnesium, potassium and copper.
The mixture of carotin, polyphenol, flavonoid and vitamin B, C, E provides the possibility of a maximum for the generation development in each stage control cancer.By the selected compositions of using these one-tenth to be grouped into, it is very ideal that they synergism tell on.
Claims (12)
1. the compositions that can prevent carcinoma of prostate is characterized in that the effective ingredient of said composition is made up of lycopene, vitamin B1, vitamin B2, vitamin B3, vitamin B6, vitamin B12, vitamin C, caffeine, epicatechin, L-Epicatechin gallate, epigallo catechin, epigallocatechin gallate (EGCG), Quercetin and vitamin E.
2. a kind of compositions of preventing carcinoma of prostate according to claim 1 is characterized in that in the effective ingredient of said composition that the shared percentage ratio of lycopene is no less than 1.4%.
3. a kind of compositions of preventing carcinoma of prostate according to claim 1 is characterized in that in the effective ingredient of said composition that the shared percentage ratio of vitamin B1 is no less than 0.3%; The shared percentage ratio of vitamin B2 is no less than 0.4%; The shared percentage ratio of vitamin B3 is no less than 2.4%; The shared percentage ratio of vitamin B6 is no less than 0.5%; The shared percentage ratio of vitamin B12 is no less than 0.0015%; The shared percentage ratio of vitamin C is no less than 12.2%; Vitamin E is no less than 1.8%.
4. a kind of compositions of preventing carcinoma of prostate according to claim 1 is characterized in that in the effective ingredient of said composition that the shared percentage ratio of caffeine is no less than 10.5%.
5. a kind of compositions of preventing carcinoma of prostate according to claim 1, it is characterized in that in the effective ingredient of said composition that the shared percentage ratio of the compositions of epicatechin, L-Epicatechin gallate, epigallo catechin and epigallocatechin gallate (EGCG) is no less than 20.1%.
6. a kind of compositions of preventing carcinoma of prostate according to claim 1 is characterized in that in the effective ingredient of said composition that the shared percentage ratio of Quercetin is no less than 6.1%.
7. a kind of compositions of preventing carcinoma of prostate according to claim 1, it is characterized in that the shared percentage ratio of each component is respectively in the effective ingredient of said composition: lycopene is 1.4%-2.7%; Vitamin B1 is 0.3%-0.5%; Vitamin B2 is 0.4%-1.7%; Vitamin B3 is 2.4%-7.5%; Vitamin B6 is 0.5%-1.5%; Vitamin B12 is 0.0015%-0.003%; Vitamin C is 12.2%-18.5%; Coffee is because 10.5%-22.5%; The combined amount of epicatechin, L-Epicatechin gallate, epigallo catechin and epigallocatechin gallate (EGCG) is 20.1%-43.5%; Quercetin is 6.1%-28.8%; Vitamin E is 1.8%-18.6%.
8. a kind of compositions of preventing carcinoma of prostate according to claim 1, the effective dose that it is characterized in that described compositions are 800-5600 milligram every day.
9. a kind of compositions of preventing carcinoma of prostate according to claim 1 is characterized in that containing in the said composition sweetener or aminoacid or mineral or flavoring agent or pigment or above-mentioned at least two kinds combination.
10. a kind of compositions of preventing carcinoma of prostate according to claim 1, the form that it is characterized in that said composition is for liquid or solid-state.
11. the composition manufacturing method that can prevent carcinoma of prostate, it is characterized in that the green tea extract at first selecting a certain amount of Fructus Lycopersici esculenti, Fructus actinidiae chinensis, Fructus Mali pumilae and green tea or contain caffeine, epicatechin, L-Epicatechin gallate, epigallo catechin and epigallocatechin gallate (EGCG), after pulverizing, stir, mixing, carry out heat treated, stir the formation stable composition at last once more.
12. a kind of composition manufacturing method of preventing carcinoma of prostate according to claim 11, it is characterized in that, a certain amount of will making in described a certain amount of Fructus Lycopersici esculenti, Fructus actinidiae chinensis, Fructus Mali pumilae and the green tea contained following chemical compound in the compositions, and is 100 parts in the summation of following each chemical compound: lycopene wherein is no less than 1.4%; Vitamin B1 is no less than 0.3%; Vitamin B2 is no less than 0.4%; Vitamin B3 is no less than 2.4%; Vitamin B6 is no less than 0.5%; Vitamin B12 is no less than 0.0015%; Vitamin C is no less than 12.2%; Caffeine is no less than 10.5%; The compositions of epicatechin, L-Epicatechin gallate, epigallo catechin and epigallocatechin gallate (EGCG) is no less than 20.1%; Quercetin is no less than 6.1%; Vitamin E is no less than 1.8%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2008100337471A CN100569233C (en) | 2008-02-21 | 2008-02-21 | Can prevent the compositions of carcinoma of prostate |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2008100337471A CN100569233C (en) | 2008-02-21 | 2008-02-21 | Can prevent the compositions of carcinoma of prostate |
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| CN101244056A CN101244056A (en) | 2008-08-20 |
| CN100569233C true CN100569233C (en) | 2009-12-16 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2337561A4 (en) * | 2008-10-23 | 2012-04-04 | Davos Life Science Pte Ltd | Use of tocotrienol composition for the prevention of cancer |
| CA3078437A1 (en) * | 2017-10-19 | 2019-04-25 | Yale University | Inhibition of androgen receptor by extracts of medicinal herbs and compositions thereof |
| KR101917733B1 (en) * | 2017-12-19 | 2018-11-13 | 게놈앤메디신(주) | A composition for preventing, treating or improving a prostate disease, which comprisesd of extracts of Acanthopanax sessiliflorus, Phragmitis Rhizoma, and Pinus densiflora as an active ingredients |
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