CN100561200C - 用于检测存在的生物物质并使其成像的方法和设备 - Google Patents

用于检测存在的生物物质并使其成像的方法和设备 Download PDF

Info

Publication number
CN100561200C
CN100561200C CNB2004100492958A CN200410049295A CN100561200C CN 100561200 C CN100561200 C CN 100561200C CN B2004100492958 A CNB2004100492958 A CN B2004100492958A CN 200410049295 A CN200410049295 A CN 200410049295A CN 100561200 C CN100561200 C CN 100561200C
Authority
CN
China
Prior art keywords
fluorescence
biological substance
signal
reflection
background
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2004100492958A
Other languages
English (en)
Chinese (zh)
Other versions
CN1677088A (zh
Inventor
L·S·鲍尔斯
C·R·洛伊德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MICROBIOSYSTEMS Ltd PARTNERSHI
Original Assignee
MICROBIOSYSTEMS Ltd PARTNERSHI
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MICROBIOSYSTEMS Ltd PARTNERSHI filed Critical MICROBIOSYSTEMS Ltd PARTNERSHI
Publication of CN1677088A publication Critical patent/CN1677088A/zh
Application granted granted Critical
Publication of CN100561200C publication Critical patent/CN100561200C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/27—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection ; circuits for computing concentration
    • G01N21/274—Calibration, base line adjustment, drift correction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N2021/1734—Sequential different kinds of measurements; Combining two or more methods
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mathematical Physics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biomedical Technology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CNB2004100492958A 2004-04-02 2004-06-10 用于检测存在的生物物质并使其成像的方法和设备 Expired - Fee Related CN100561200C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/817,647 US7186990B2 (en) 2002-01-22 2004-04-02 Method and apparatus for detecting and imaging the presence of biological materials
US10/817,647 2004-04-02

Publications (2)

Publication Number Publication Date
CN1677088A CN1677088A (zh) 2005-10-05
CN100561200C true CN100561200C (zh) 2009-11-18

Family

ID=34887789

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004100492958A Expired - Fee Related CN100561200C (zh) 2004-04-02 2004-06-10 用于检测存在的生物物质并使其成像的方法和设备

Country Status (6)

Country Link
US (1) US7186990B2 (cg-RX-API-DMAC10.html)
EP (1) EP1582860A1 (cg-RX-API-DMAC10.html)
JP (1) JP2005292112A (cg-RX-API-DMAC10.html)
CN (1) CN100561200C (cg-RX-API-DMAC10.html)
CA (1) CA2466433A1 (cg-RX-API-DMAC10.html)
SG (1) SG144722A1 (cg-RX-API-DMAC10.html)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6380751B2 (en) 1992-06-11 2002-04-30 Cascade Microtech, Inc. Wafer probe station having environment control enclosure
US5345170A (en) 1992-06-11 1994-09-06 Cascade Microtech, Inc. Wafer probe station having integrated guarding, Kelvin connection and shielding systems
US6232789B1 (en) 1997-05-28 2001-05-15 Cascade Microtech, Inc. Probe holder for low current measurements
US5561377A (en) 1995-04-14 1996-10-01 Cascade Microtech, Inc. System for evaluating probing networks
US5914613A (en) 1996-08-08 1999-06-22 Cascade Microtech, Inc. Membrane probing system with local contact scrub
US6002263A (en) 1997-06-06 1999-12-14 Cascade Microtech, Inc. Probe station having inner and outer shielding
US6256882B1 (en) 1998-07-14 2001-07-10 Cascade Microtech, Inc. Membrane probing system
US6578264B1 (en) 1999-06-04 2003-06-17 Cascade Microtech, Inc. Method for constructing a membrane probe using a depression
US6445202B1 (en) 1999-06-30 2002-09-03 Cascade Microtech, Inc. Probe station thermal chuck with shielding for capacitive current
US6838890B2 (en) 2000-02-25 2005-01-04 Cascade Microtech, Inc. Membrane probing system
US6965226B2 (en) 2000-09-05 2005-11-15 Cascade Microtech, Inc. Chuck for holding a device under test
US6914423B2 (en) 2000-09-05 2005-07-05 Cascade Microtech, Inc. Probe station
DE20114544U1 (de) 2000-12-04 2002-03-28 Cascade Microtech, Inc., Beaverton, Oreg. Wafersonde
US7355420B2 (en) 2001-08-21 2008-04-08 Cascade Microtech, Inc. Membrane probing system
US6777964B2 (en) 2002-01-25 2004-08-17 Cascade Microtech, Inc. Probe station
JP2005527823A (ja) 2002-05-23 2005-09-15 カスケード マイクロテック インコーポレイテッド デバイスのテスト用プローブ
US6847219B1 (en) 2002-11-08 2005-01-25 Cascade Microtech, Inc. Probe station with low noise characteristics
US6724205B1 (en) 2002-11-13 2004-04-20 Cascade Microtech, Inc. Probe for combined signals
US7250779B2 (en) 2002-11-25 2007-07-31 Cascade Microtech, Inc. Probe station with low inductance path
US6861856B2 (en) 2002-12-13 2005-03-01 Cascade Microtech, Inc. Guarded tub enclosure
US7221172B2 (en) 2003-05-06 2007-05-22 Cascade Microtech, Inc. Switched suspended conductor and connection
US7492172B2 (en) 2003-05-23 2009-02-17 Cascade Microtech, Inc. Chuck for holding a device under test
US7057404B2 (en) 2003-05-23 2006-06-06 Sharp Laboratories Of America, Inc. Shielded probe for testing a device under test
US7250626B2 (en) 2003-10-22 2007-07-31 Cascade Microtech, Inc. Probe testing structure
GB2425844B (en) 2003-12-24 2007-07-11 Cascade Microtech Inc Active wafer probe
US7187188B2 (en) 2003-12-24 2007-03-06 Cascade Microtech, Inc. Chuck with integrated wafer support
JP2008502167A (ja) 2004-06-07 2008-01-24 カスケード マイクロテック インコーポレイテッド 熱光学チャック
US7330041B2 (en) 2004-06-14 2008-02-12 Cascade Microtech, Inc. Localizing a temperature of a device for testing
KR101157449B1 (ko) 2004-07-07 2012-06-22 캐스케이드 마이크로테크 인코포레이티드 멤브레인 서스펜디드 프로브를 구비한 프로브 헤드
WO2006022823A1 (en) 2004-07-29 2006-03-02 Centrus International, Inc. Detection of microorganisms with a fluorescence-based device
DE202005021435U1 (de) 2004-09-13 2008-02-28 Cascade Microtech, Inc., Beaverton Doppelseitige Prüfaufbauten
US7545969B2 (en) * 2004-12-16 2009-06-09 Alliant Techsystems Inc. Method and system for wide-area ultraviolet detection of forensic evidence
US7535247B2 (en) 2005-01-31 2009-05-19 Cascade Microtech, Inc. Interface for testing semiconductors
US7656172B2 (en) 2005-01-31 2010-02-02 Cascade Microtech, Inc. System for testing semiconductors
JP2006263044A (ja) * 2005-03-23 2006-10-05 Fuji Photo Film Co Ltd 蛍光検出システム
US7449899B2 (en) 2005-06-08 2008-11-11 Cascade Microtech, Inc. Probe for high frequency signals
US7619419B2 (en) 2005-06-13 2009-11-17 Cascade Microtech, Inc. Wideband active-passive differential signal probe
JP5289675B2 (ja) * 2005-12-14 2013-09-11 京セラディスプレイ株式会社 汚染物質の除去方法
DE112007001399T5 (de) 2006-06-09 2009-05-07 Cascade Microtech, Inc., Beaverton Messfühler für differentielle Signale mit integrierter Symmetrieschaltung
US7723999B2 (en) 2006-06-12 2010-05-25 Cascade Microtech, Inc. Calibration structures for differential signal probing
US7764072B2 (en) 2006-06-12 2010-07-27 Cascade Microtech, Inc. Differential signal probing system
US7403028B2 (en) 2006-06-12 2008-07-22 Cascade Microtech, Inc. Test structure and probe for differential signals
US7443186B2 (en) 2006-06-12 2008-10-28 Cascade Microtech, Inc. On-wafer test structures for differential signals
DE102006000318A1 (de) 2006-07-03 2008-01-10 Novineon Healthcare Technology Partners Gmbh Vorrichtung zur Blutungsdetektion
US20080012578A1 (en) * 2006-07-14 2008-01-17 Cascade Microtech, Inc. System for detecting molecular structure and events
US7876114B2 (en) 2007-08-08 2011-01-25 Cascade Microtech, Inc. Differential waveguide probe
US7615761B2 (en) * 2007-09-10 2009-11-10 Coherent, Inc. Trace evidence detection using multiple laser light sources
WO2009036105A2 (en) * 2007-09-11 2009-03-19 Baxter International Inc Infusion therapy sensor system
US8512975B2 (en) * 2008-07-24 2013-08-20 Biomerieux, Inc. Method for detection and characterization of a microorganism in a sample using time dependent spectroscopic measurements
US7888957B2 (en) 2008-10-06 2011-02-15 Cascade Microtech, Inc. Probing apparatus with impedance optimized interface
US8647835B2 (en) 2008-10-31 2014-02-11 BIO MéRIEUX, INC. Methods for separation, characterization and/or identification of microorganisms using spectroscopy
US10059975B2 (en) * 2008-10-31 2018-08-28 Biomerieux, Inc. Methods for the isolation and identification of microorganisms
ES2538497T3 (es) 2008-10-31 2015-06-22 Biomerieux, Inc Métodos para la identificación de microorganismos usando espectrometría de masas
MX2011004169A (es) * 2008-10-31 2011-09-27 Bio Merieux Inc Metodos para la separacion y caracterizacion de microorganismos utilizando agentes identificadores.
EP2361377B1 (en) * 2008-10-31 2018-01-31 Biomerieux, Inc Method for identification of microorganisms using raman spectroscopy
WO2010062350A1 (en) * 2008-10-31 2010-06-03 Biomerieux, Inc. Methods for detection, characterization and/or identification of microorganisms in a sealed container
US8652800B2 (en) * 2008-10-31 2014-02-18 Biomerieux, Inc. Method for separation, characterization and/or identification of microorganisms using spectroscopy
US8410806B2 (en) 2008-11-21 2013-04-02 Cascade Microtech, Inc. Replaceable coupon for a probing apparatus
US8319503B2 (en) 2008-11-24 2012-11-27 Cascade Microtech, Inc. Test apparatus for measuring a characteristic of a device under test
MX2011005988A (es) * 2008-12-16 2011-09-01 Bio Merieux Inc Metodos para la caracterizacion de microorganismos en un medio solido o semisolido.
CA2760982C (en) 2009-05-15 2019-01-15 Biomerieux, Inc. System and methods for rapid identification and/or characterization of a microbial agent in a sample
CN102460183B (zh) † 2009-05-15 2015-04-15 生物梅里埃有限公司 用于微生物检测设备的自动化加载机构
BR112012031252B1 (pt) * 2010-06-11 2020-06-30 B. Braun Avitum Ag aparelho para tratamento extracorpóreo de sangue
JP5682976B2 (ja) * 2010-09-17 2015-03-11 国立大学法人東北大学 抗体を成分として含む医薬品の有効性の判定方法
CN103221981A (zh) * 2010-10-27 2013-07-24 皇家飞利浦电子股份有限公司 存在检测系统和照明系统
US20120119110A1 (en) * 2010-11-16 2012-05-17 Research In Motion Limited Apparatus, and associated method, for detecting contamination of an object
EP2520923A1 (en) 2011-05-06 2012-11-07 bioMérieux Bio-imaging method and system
WO2013096404A1 (en) 2011-12-22 2013-06-27 Becton, Dickinson And Company Methods and apparatus for rapid detection of infectious microorganisms
WO2014039082A1 (en) 2012-09-04 2014-03-13 Becton, Dickinson And Company Bacterial pre-concentration and detection technique
US20140125809A1 (en) 2012-11-02 2014-05-08 Syntronics, Llc Digital ruvis camera
WO2015089514A2 (en) * 2013-12-13 2015-06-18 Colorado State University Research Foundation Nano-stamp and matched reader for anti-counterfeiting applications
US10039934B2 (en) * 2013-12-30 2018-08-07 PhotonEdge Inc. Multi-wavelength interleaved optical stimulation
WO2016022894A1 (en) * 2014-08-07 2016-02-11 Teleflex Medical Incorporated Urine sensing optical fiber probe and system for percutaneous nephrostomy
US9880159B2 (en) 2014-10-01 2018-01-30 Linda S. Powers Cartridge-based detection system
US9867250B1 (en) 2015-04-20 2018-01-09 The Arizona Board Of Regents On Behalf Of The University Of Arizona System having a configurable pico-second pulsed LED driver circuit and photomultiplier tube biasing and gating circuits for real-time, time-resolved transient recording of fluorescence
WO2018045270A1 (en) * 2016-09-02 2018-03-08 Singular Bio, Inc. Systems and methods for single molecule quantification
US10846852B2 (en) * 2016-12-23 2020-11-24 Bio-Rad Laboratories, Inc. Reduction of background signal in blot images
JP7007122B2 (ja) * 2017-07-11 2022-01-24 浜松ホトニクス株式会社 試料観察装置及び試料観察方法
CN110892251B (zh) * 2017-07-11 2023-09-15 浜松光子学株式会社 试样观察装置和试样观察方法
CN110197174A (zh) * 2018-02-26 2019-09-03 刘风华 文物、字画和原产商品的数字化技术
US11269203B2 (en) 2020-01-23 2022-03-08 Hong Kong Applied Science And Technology Institute Company Limited Multifocal system with polarization-independent focusing
US11408825B2 (en) 2020-08-28 2022-08-09 Hong Kong Applied Science and Technology Research Institute Company Limited Forensic detector and the system thereof
DE102021127696B3 (de) * 2021-10-25 2023-03-09 Technische Universität Dresden, Körperschaft des öffentlichen Rechts Verfahren und Anordnung zur in-ovo Geschlechtsbestimmung von Vogeleiern

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968766A (en) * 1998-03-31 1999-10-19 B.E. Safe Method and apparatus for sensing the presence of microbes
US20030138875A1 (en) * 2002-01-22 2003-07-24 Powers Linda S. Method and apparatus for detecting the presence of microbes and determining their physiological status

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3580525A (en) * 1967-11-21 1971-05-25 Telefunken Patent Arrangement maintaining constant tape tension in magnetic tape recorders
US3850525A (en) 1973-07-09 1974-11-26 Beckman Instruments Inc Simultaneous multiple measurements in laser photometers
US4745285A (en) 1986-08-21 1988-05-17 Becton Dickinson And Company Multi-color fluorescence analysis with single wavelength excitation
US4900934A (en) 1987-07-15 1990-02-13 University Of Utah Apparatus for simultaneous visualization and measurement of fluorescence from fluorescent dye-treated cell preparations and solutions
US5208651A (en) 1991-07-16 1993-05-04 The Regents Of The University Of California Apparatus and method for measuring fluorescence intensities at a plurality of wavelengths and lifetimes
US5418371A (en) 1993-02-01 1995-05-23 Aslund; Nils R. D. Apparatus for quantitative imaging of multiple fluorophores using dual detectors
US5294799A (en) 1993-02-01 1994-03-15 Aslund Nils R D Apparatus for quantitative imaging of multiple fluorophores
US5424959A (en) 1993-07-19 1995-06-13 Texaco Inc. Interpretation of fluorescence fingerprints of crude oils and other hydrocarbon mixtures using neural networks
US5474910A (en) 1993-10-15 1995-12-12 Alfano; Robert R. Method and device for detecting biological molecules and/or microorganisms within a desired area or space
US5491343A (en) 1994-03-25 1996-02-13 Brooker; Gary High-speed multiple wavelength illumination source, apparatus containing the same, and applications thereof to methods of irradiating luminescent samples and of quantitative luminescence ratio microscopy
US5701012A (en) 1996-03-19 1997-12-23 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Fluorescent biological particle detection system
US5760406A (en) 1996-06-03 1998-06-02 Powers; Linda Method and apparatus for sensing the presence of microbes
US5866430A (en) 1996-06-13 1999-02-02 Grow; Ann E. Raman optrode processes and devices for detection of chemicals and microorganisms
AU8148898A (en) 1997-06-23 1999-01-04 Luminex Corporation Interlaced lasers for multiple fluorescence measurement
US6124597A (en) 1997-07-07 2000-09-26 Cedars-Sinai Medical Center Method and devices for laser induced fluorescence attenuation spectroscopy

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968766A (en) * 1998-03-31 1999-10-19 B.E. Safe Method and apparatus for sensing the presence of microbes
US20030138875A1 (en) * 2002-01-22 2003-07-24 Powers Linda S. Method and apparatus for detecting the presence of microbes and determining their physiological status

Also Published As

Publication number Publication date
US7186990B2 (en) 2007-03-06
EP1582860A1 (en) 2005-10-05
US20040197771A1 (en) 2004-10-07
CA2466433A1 (en) 2005-10-02
JP2005292112A (ja) 2005-10-20
CN1677088A (zh) 2005-10-05
SG144722A1 (en) 2008-08-28

Similar Documents

Publication Publication Date Title
CN1677088A (zh) 用于检测存在的生物物质并使其成像的方法和设备
JP4033754B2 (ja) 微生物の存在の検出及びその生理学的状態の決定のための方法及び装置
Estes et al. Reagentless detection of microorganisms by intrinsic fluorescence
Zeng et al. Development of in situ sensors for chlorophyll concentration measurement
US10101274B2 (en) Optical interrogation device
CN107003239B (zh) 自触发流式细胞计数仪
CN101464409B (zh) 快速定量检测细菌的装置及方法
Simões et al. An ultrasensitive fluorimetric sensor for pre-screening of water microbial contamination risk
Herzog et al. Quantitative spectroscopic characterization of near-uv/visible e. coli (pyac4), b. subtilis (py79), and green bread mold fungus fluorescence for diagnostic applications
CN105717080B (zh) 一种用于上转换荧光试纸条的检测方法
CN106970058A (zh) 一种双荧光发射面的微量物质检测仪及检测方法
US7211377B1 (en) Method for detecting the presence of dormant cryptobiotic microorganisms
JP4487985B2 (ja) 微生物計量装置
Moger et al. The application of fluorescence lifetime readouts in high-throughput screening
Knight et al. The application of fluorescence polarisation for the enhanced detection of green fluorescent protein (GFP) in the presence of cellular auto-fluorescence and other green fluorescent compounds
WO2003023375A2 (en) Toxicity monitoring
CN212199262U (zh) 一种基于激光光谱技术的病菌检测仪器
Kopczynski et al. Laser induced fluorescence system for detection of biological agents: European project FABIOLA
CN100372947C (zh) 转基因物种的荧光相关光谱检测方法
Lloyd Powers et al.
Chen et al. A sensitive fluorescence analysis method of pathogenic microorganisms based on Silicon Photomultiplier
Aksoy et al. Emerging technologies for fluorescence-based optical test strip readers
JP2006333812A (ja) 微生物計量方法および微生物計量装置
CA2466387A1 (en) Method for detecting the presence of dormant cryptobiotic microorganisms
Kist Fluorescent Dye Labels and Stains: A Database of Photophysical Properties

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20091118

Termination date: 20140610

EXPY Termination of patent right or utility model