CN100560121C - A kind of Chinese medicinal capsule for the treatment of liver-Qi pent-up type gland hyperplasia - Google Patents
A kind of Chinese medicinal capsule for the treatment of liver-Qi pent-up type gland hyperplasia Download PDFInfo
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- CN100560121C CN100560121C CNB200710017045XA CN200710017045A CN100560121C CN 100560121 C CN100560121 C CN 100560121C CN B200710017045X A CNB200710017045X A CN B200710017045XA CN 200710017045 A CN200710017045 A CN 200710017045A CN 100560121 C CN100560121 C CN 100560121C
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Abstract
The invention discloses a kind of Chinese medicinal capsule for the treatment of liver-Qi pent-up type gland hyperplasia, it is characterized in that it is made up of the medicine material of following percentage by weight: Olibanum (processed) 2.4-3.6%, Myrrha (processed) 2.4-3.6%, Radix Bupleuri 4.0-6.0%, Thallus Laminariae (Thallus Eckloniae) 4.0-6.0%, Sargassum 4.0-6.0%, Squama Manis 4.0-6.0%, Scolopendra 4.0-6.0%, Pericarpium Citri Reticulatae 4.8-7.2%, Radix Paeoniae Rubra 4.8-7.2%, Radix Paeoniae Alba 4.8-7.2%, Fructus Toosendan 8-7.2%, Semen Vaccariae 6.0-9.0%, Herba Artemisiae Anomalae 6.0-9.0%, Spina Gleditsiae 12.0-18.0%, Fructus Hordei Germinatus 2.0-18.0%.The Chinese medicinal capsule of this treatment liver-Qi pent-up type gland hyperplasia, with strong points, cure rate is higher, treatment time is short, taking convenience, medical expense are low, have no side effect, be exclusively used in the treatment of the liver-Qi pent-up type gland hyperplasia that the various causes of disease cause.
Description
Technical field
The invention belongs to a kind of medicine for the treatment of mastopathy, especially a kind of Chinese medicinal capsule for the treatment of liver-Qi pent-up type gland hyperplasia.
Background technology
Cyclomastopathy is a kind of commonly encountered diseases of women, frequently-occurring disease, mostly occur at 25-40 between year, sickness rate is up to about 40%, and the city is more than the rural area, and sickness rate increased to some extent in recent years, and be tending towards rejuvenation, severe patient can bring out breast carcinoma, and the rate that cancerates is up to about 20%, therefore, the active treatment cyclomastopathy, the prevention breast disease is cancerated and reduces breast cancer incidence is necessary.Main clinic symptoms is breast caking, mastalgia, and the characteristics that change with menstrual cycle or situation are arranged.Its cause of disease doctor trained in Western medicine is thought: due to periodically disorder of hormone secretion or mammary gland tissue increase the sensitivity of hormone; The traditional Chinese medical science is thought the category of " nodules of the breast ", " newborn painful abdominal mass ", " nodule in the breast ", mainly be divided into liver qi stagnation type, kidney yang deficiency syndrome or two type mixed types, characteristic of disease belongs to deficiency in origin and excess in superficiality, Chong and Ren channel disorder is for falling ill originally, depression of liver-QI, the expectorant blood coagulation stasis of blood are the mark of morbidity, and sick at liver,spleen,kidney, the liver failing to maintain the normal flow of QI, dysfunction of the spleen in transportation, deficiency of the kidney, so that stagnation of Qi and phelgm, blood stasis in bulk, Chong and Ren channel disorder hinder in newborn network and form " nodules of the breast ".At present, the medicine of treatment cyclomastopathy has multiple, the hormone therapy of doctor trained in Western medicine versatility, Western medicine commonly used has hormone antagonist medicine (tamoxifen etc.), androgens medicine and prolactin antagonist medicine, though this type of medicine is effective, side effect is big, curative effect do not consolidate, easily recurrence, breast are yielding, easily cause endocrine regulation, the cycle of taking is long, should not take for a long time.How Chinese traditional treatment transfers the medicine that dashes with nourishing blood to suppress the hyperactive liver, regulating QI to relieve pain, hard masses softening and resolving, the kidney invigorating, forms different prescription treatments, and its prescription is various, but exists curative effect definite inadequately mostly, and specific aim is not strong, and treatment cycle is long, takes shortcomings such as inconvenience.
Summary of the invention
The object of the present invention is to provide a kind of good effect, instant effect, taking convenience, non-relapse after healing, and have no adverse reaction, be applicable to the Chinese medicinal capsule of the treatment liver-Qi pent-up type gland hyperplasia of treatment liver-Qi pent-up type gland hyperplasia.
For reaching above purpose, the technical solution used in the present invention is: this a kind of Chinese medicinal capsule for the treatment of liver-Qi pent-up type gland hyperplasia is characterized in that it is made up of the medicine material of following percentage by weight: Olibanum (processed) 2.4-3.6%, Myrrha (processed) 2.4-3.6%, Radix Bupleuri 4.0-6.0%, Thallus Laminariae (Thallus Eckloniae) 4.0-6.0%, Sargassum 4.0-6.0%, Squama Manis 4.0-6.0%, Scolopendra 4.0-6.0%, Pericarpium Citri Reticulatae 4.8-7.2%, Radix Paeoniae Rubra 4.8-7.2%, Radix Paeoniae Alba 4.8-7.2%, Fructus Toosendan 4.8-7.2%, Semen Vaccariae 6.0-9.0%, Herba Artemisiae Anomalae 6.0-9.0%, Spina Gleditsiae 12.0-18.0%, Fructus Hordei Germinatus 12.0-18.0%.The optimum of the raw material weight percentage ratio described in the Chinese medicinal capsule pharmaceutical formulation of the treatment liver-Qi pent-up type gland hyperplasia described in the present invention is: Olibanum (processed) 3%, Myrrha (processed) 3%, Radix Bupleuri 5%, Thallus Laminariae (Thallus Eckloniae) 5%, Sargassum 5%, Squama Manis 5%, Scolopendra 5%, Pericarpium Citri Reticulatae 6.0%, Radix Paeoniae Rubra 6.0%, the Radix Paeoniae Alba 6.0%, Fructus Toosendan 6.0%, Semen Vaccariae 7.5%, Herba Artemisiae Anomalae 7.5%, Spina Gleditsiae 15%, Fructus Hordei Germinatus 15%.Making step of the present invention is: at first load weighted Olibanum (processed), Myrrha (processed) in the above proportioning pulverized jointly, crossed 100 mesh sieves, make mixing fine powders, and standby.Then to load weighted Spina Gleditsiae in the above proportioning, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Semen Vaccariae, Squama Manis, Radix Bupleuri, Fructus Toosendan, Herba Artemisiae Anomalae, Thallus Laminariae (Thallus Eckloniae), Sargassum, Fructus Hordei Germinatus, Pericarpium Citri Reticulatae, Scolopendra need be soaked 12 hours, boil jointly three times, boiled 2 hours for the first time, boiled 1 hour for the second time, boil half an hour for the third time, filter, it is 1.25-1.30 (60 ℃) that filtrate decompression is concentrated into relative density, adds above-mentioned Olibanum (processed), the mixing fine powders of Myrrha (processed), mixing, the low-temperature reduced-pressure drying is pulverized, and crosses 40 mesh sieves, mixing, incapsulate, be the Chinese medicinal capsule of this treatment liver-Qi pent-up type gland hyperplasia, packing is taken fully.
Pharmacology of the present invention is: because the cause of disease of liver-Qi pent-up type gland hyperplasia disease, how by worry impairing spleen, angry impairing the liver, depression of liver-QI, stagnation of QI due to depression of the liver, or accumulate in the worry impairing spleen, dysfunction of the spleen in transportation, phlegm-damp, so that liver spleen two is hindered, mental disorder is tied mutually, the stasis of blood stagnates and due to the in bulk, therefore, the rule of treatment is answered depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving.
Radix Bupleuri among the present invention: soothing liver-QI for relieving depression, reducing fever by reconciliation, ascending up spleen-Qi and Yang; Fructus Toosendan: soothing liver-QI circulation of qi promoting, pain relieving; Fructus Hordei Germinatus: help digestion and in, move back breast; Pericarpium Citri Reticulatae: regulate the flow of vital energy and be good for the stomach, above four Chinese medicine, effect with common depressed liver-energy dispersing and QI regulating.Radix Paeoniae Rubra, the Radix Paeoniae Alba: the promoting the circulation of blood of enriching blood, easing the affected liver to relieve pain; Semen Vaccariae, Spina Gleditsiae, Herba Artemisiae Anomalae, Squama Manis: promoting the circulation of blood is stimulated the menstrual flow, detumescence and apocenosis, dispelling wind and removing obstruction in the collateral; Olibanum (processed), Myrrha (processed): the heat radiation of invigorating blood circulation, subduing swelling and relieving pain, life.More than eight flavor medicines, have the effect of blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain, be the key medicine of treatment sore; Thallus Laminariae (Thallus Eckloniae), Sargassum: hard masses softening and resolving; Scolopendra: the spasmolytic that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., separate sore, control sore swollen toxin, scrofula is festered.Full side has the effect of depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, dissipation lump.
Pharmacological research confirms, the vigor of monoamine oxidase, MAO in depressed liver-energy dispersing and QI regulating, drug for invigorating blood circulation and eliminating stasis can suppress to organize suppresses the synthetic of collagen fiber, thereby promotes the absorption of interior lump of mammary gland and fiber, hard masses softening and resolving medicine amount of iodine height, help to stimulate the interstitialcellstimulating hormone (ICSH) secretion, improve luteal function, thereby adjusted estrogen and lutein ratio, promote the absorption of pathological product and inflammatory exudate, with the blocking-up vicious cycle, eliminate clinical symptoms effectively, thereby improved clinical efficacy.
Instructions of taking: oral, 2-3 time on the one, each 2, one month is a course of treatment.Period in a medicine avoids pungent food, greasy food, as Fructus Capsici, liquor, too much Animal fat.The careful usefulness of anemia of pregnant woman.
The invention has the advantages that: compare with the Chinese Traditional Medicines of the treatment cyclomastopathy of present clinical practice, with strong points, cure rate is higher, treatment time is short, taking convenience, medical expense are low, have no side effect, and is exclusively used in the treatment of the liver-Qi pent-up type gland hyperplasia that the various causes of disease cause.
The clinical efficacy testing data is analyzed
One, the diagnostic criteria of liver-Qi pent-up type gland hyperplasia
1, diagnostic criteria: the diagnostic criteria of nodules of the breast in " disease of tcm diagnosis criterion of therapeutical effect " diagnosis that standard of formulating according to breast disease meeting first in 1987 and State Administration of Traditional Chinese Medicine in 1994 formulate.
2, diagnostic symptom:
Clinical have lump in breast and with pain, and untreated can not spontaneous remission be got rid of the physiological mastalgia, and as through the fore udder mild pain, adolescence is pain etc. for the moment.
Liver qi stagnation type: be generally 18 years old 35 years old young women, young and aggressive, depressed rage impairing the liver, the liver failing to maintain the normal flow of QI and harmony stagnate, tiredly towards long-pending month cause newborn network obstructed, main performance: susceptible to lose temper due to restlessness, emotion are gloomy, mastalgia, warp before increases the weight of, lump fills the air and in the form of sheets pliable and tough, increase the weight of with the variation of feelings will, thin lingual fur and Huang, stringy and thready pulse and counting.
Two, source of data
This group case all derives from my institute's department of obstetrics and gynecology outpatient service calendar year 2001 to 2006 year case, all case is all through infrared ray breast scanner or ultrasound diagnosis, be suspected to have canceration person's row puncture pathologic finding, make a definite diagnosis 1500 routine patients, 18-25 year 216 examples wherein, 26-30 year 362 examples, 31-40 year 480 examples, 41-50 year 285 examples, 51-79 year 157 examples; Companion's distending pain of the breast person 1326 examples, relevant person's 832 examples with menstruation, menoxenia person 298 examples, amenorrhea person's 67 examples, row hysterectomy person 12 examples; The course of disease 1 year-15 years, average 3.6 years; One-sided patient's 418 examples, bilateral is sent out patient's 1082 examples; Clinical inspection, look into can touch differ in size, quality is tough and hard, clear border, the proliferation of tenderness is arranged; Tuberosity hypertrophy 735 examples wherein, lamellar hypertrophy 528 examples, streak hypertrophy 237 examples; Conscious breast is through preceding distending pain, tuberosity is at 0.5cmx0.8cm, noctovisor scan is that I level ghost person is slight hypertrophy 725 examples, conscious distending pain of the breast is obvious, tuberosity is at 0.9cmx1.5cm, and noctovisor scan II level ghost person is moderate hypertrophy 515 examples, and conscious distending pain of the breast is remarkable, tuberosity is at 1.6cmx3.0cm, and noctovisor scan III level ghost person is severe hypertrophy 260 examples
Three, therapeutic outcome analysis
1. criterion of therapeutical effect
Criterion of therapeutical effect is formulated with reference to the standard of national breast disease Nantong meeting formulation in 1987 and " the disease of tcm diagnosis criterion of therapeutical effect " of State Administration of Traditional Chinese Medicine's formulation in 1994
Clinical cure: lump disappears, and pain disappears, and does not recur in three months after the drug withdrawal;
Produce effects: mastalgia disappears, and the lump maximum gauge dwindles 1/2;
Effectively: mastalgia alleviates, and the lump maximum gauge dwindles less than 1/2, or lump dwindles more than 1/2, and mastalgia does not alleviate;
Invalid: hardening of lump hypertrophy or simple pain relief lump do not dwindle.
Three, therapeutic outcome analysis
By to above 1500 routine patient treatments, treat and judge curative effect 3 courses of treatment,, determine cured person 921 examples altogether by above criterion of therapeutical effect, cure rate is 61.4%, one of them course of treatment healing person's 284 examples, two the course of treatment healing person's 423 examples, three the course of treatment healing person's 214 examples, produce effects 319 examples, effective 251 examples, invalid 9 examples, total effective rate 99%.
Through tracing study 2 years, in 921 examples of healing, recur 21 examples, account for 2.3%, still take the Chinese medicinal capsule of this treatment liver-Qi pent-up type gland hyperplasia and cure; Without any side effects and the untoward reaction of clinical observation.
The specific embodiment
Embodiment 1
Produce this Chinese medicinal capsule of 1000g, take by weighing: Olibanum (processed) 30 grams, Myrrha (processed) 30 grams, Radix Bupleuri 50 grams, Thallus Laminariae (Thallus Eckloniae) 50 grams, Sargassum 50 grams, Squama Manis 50 grams, Scolopendra 50 grams, Pericarpium Citri Reticulatae 60 grams, Radix Paeoniae Rubra 60 grams, the Radix Paeoniae Alba 60 grams, Fructus Toosendan 60 grams, Semen Vaccariae 75 grams, Herba Artemisiae Anomalae 75 grams, Spina Gleditsiae 150 grams, Fructus Hordei Germinatus 150 grams.
The Olibanum (processed), the Myrrha (processed) that take by weighing are pulverized jointly, crossed 100 mesh sieves, get mixing fine powders, standby; Remaining Spina Gleditsiae, Radix Paeoniae Rubra, the Radix Paeoniae Alba, Semen Vaccariae, Squama Manis, Radix Bupleuri, Fructus Toosendan, Herba Artemisiae Anomalae, Thallus Laminariae (Thallus Eckloniae), Sargassum, Fructus Hordei Germinatus, Pericarpium Citri Reticulatae, Scolopendra were soaked 12 hours, boiled 2 hours for the first time jointly three times, 1 hour for the second time, half an hour for the third time, collecting decoction, filter, it is 1.25-1.30 (60 ℃) that filtrate decompression is concentrated into relative density, adds above-mentioned Olibanum (processed), Myrrha (processed) mixing fine powders, mixing, the low-temperature reduced-pressure drying is pulverized, cross 40 mesh sieves, mixing incapsulates, promptly.
Adopt this proportioning, treat liver-Qi pent-up type gland hyperplasia 120 examples altogether, cure 93 examples, cure rate 77.5%, produce effects 18 examples, obvious effective rate 15.0%, 9 examples that take a turn for the better, improvement rate 7.5%.
Model case 1
Wang Hua, woman, 28 years old, Kou Zhen people from village, Laiwu City Laicheng district, because family matters are bothered and met and be laid off, mood is not relaxed, emotional, dysphoria, insomnia, with menoxenia occurring, distending pain of the breast is through before increasing the weight of nearly half a year, pain is to oxter and arm radiation, and forearm pain can not be lifted, and goes up and LOQ tuberosity lamellar hypertrophy outside ultrasound diagnosis is bimastism, once obeyed RUHE SANJIE PIAN, RUPIXIAO ease pill, poor effect such as Chinese medicine decoction, come to go to a doctor, symptom is the same, the little Huang of thin lingual fur, pale tongue, stringy and thready pulse, Chinese medical discrimination are the liver qi stagnation type nodules of the breast, give this Chinese medicinal capsule, each 2, every day three times, withdraw other drug, the rear udder attachment distending pain faded away in three days, checked after three weeks that tuberosity and lamellar hypertrophy disappear, and noctovisor scan is normal, clinical cure is followed up a case by regular visits to and is not had recurrence half a year.
Embodiment 2
Produce this Chinese medicinal capsule of 1000g, take by weighing: Olibanum (processed) 32 grams, Myrrha (processed) 32 grams, Radix Bupleuri 54 grams, Thallus Laminariae (Thallus Eckloniae) 54 grams, Sargassum 54 grams, Squama Manis 54 grams, Scolopendra 54 grams, Pericarpium Citri Reticulatae 58 grams, Radix Paeoniae Rubra 18 grams, the Radix Paeoniae Alba 58 grams, Fructus Toosendan 58 grams, Semen Vaccariae 71 grams, Herba Artemisiae Anomalae 71 grams, Spina Gleditsiae 146 grams, Fructus Hordei Germinatus 146 grams.
Production technology is with embodiment 1.Adopt this prescription treatment 80 examples, cure 56 examples altogether, cure rate is 70%, produce effects 16 examples, obvious effective rate 20%, 6 examples that take a turn for the better, improvement rate 7.5%, invalid 2 examples, inefficiency 2.5%.
Model case
Dou Feihong, woman, 30 years old, Zhang Jiawa people from town, Laiwu City Laicheng district.Mammary gland lamellar hypertrophy goes up in addition and lower quadrant is main, and maximum hypertrophy piece is 5.0cmx7.0cm, and distending pain of the breast has difficulty in going to sleep night, menoxenia, and thin white fur of tongue, deep-thready pulse, tcm diagnosis is a nodules of the breast, gives the Chinese medicinal capsule treatment, and is for oral administration, each 2, every day 3 times.Pain begins to alleviate after taking medicine 3 days, week back pain disappearance, and check that the cyclomastopathy lump disappears full the January of taking medicine.Follow up a case by regular visits to and do not have recurrence in 1 year.
Embodiment 3
Produce this Chinese medicinal capsule of 1000g, take by weighing: Olibanum (processed) 29 grams, Myrrha (processed) 29 grams, Radix Bupleuri 48 grams, Thallus Laminariae (Thallus Eckloniae) 48 grams, Sargassum 48 grams, Squama Manis 48 grams, Scolopendra 48 grams, Pericarpium Citri Reticulatae 63 grams, Radix Paeoniae Rubra 63 grams, the Radix Paeoniae Alba 63 grams, Fructus Toosendan 63 grams, Semen Vaccariae 76 grams, Herba Artemisiae Anomalae 76 grams, Spina Gleditsiae 149 grams, Fructus Hordei Germinatus 149 grams.
Production technology is with embodiment 1.Adopt this prescription treatment 100 examples, cure 72 examples altogether, cure rate is 72%, produce effects 21 examples, obvious effective rate 21%, 6 examples that take a turn for the better, improvement rate 6%, invalid 1 example, inefficiency 1%.
Model case
Li Meixiang, the woman, 38 years old, Laiwu City Laicheng district people from Dawangzhuang Town, distending pain of the breast has caking, the both sides of the chest twinge, warp before increases the weight of, chloasma faciei, thin lingual fur, white body of the tongue, shallow arteries and veins sinks carefully, examines to be cyclomastopathy.First quarter moon is obeyed this Chinese medicinal capsule before the treatment menstruation, and each 3, every day 3 times, first quarter moon is each 2 for oral administration after the menstruation, and every day 3 times, be a course of treatment January.
Patient takes medicine, and pain disappears after January, and the chloasma faciei color shoals, and two months check cyclomastopathy pieces of taking medicine are eliminated entirely.There was not recurrence in 1 year with examining.
Claims (2)
1, a kind of Chinese medicinal capsule for the treatment of liver-Qi pent-up type gland hyperplasia is characterized in that it is made up of the medicine material of following percentage by weight: Olibanum (processed) 2.4-3.6%, Myrrha (processed) 2.4-3.6%, Radix Bupleuri 4.0-6.0%, Thallus Laminariae (Thallus Eckloniae) 4.0-6.0%, Sargassum 4.0-6.0%, Squama Manis 4.0-6.0%, Scolopendra 4.0-6.0%, Pericarpium Citri Reticulatae 4.8-7.2%, Radix Paeoniae Rubra 4.8-7.2%, Radix Paeoniae Alba 4.8-7.2%, Fructus Toosendan 8-7.2%, Semen Vaccariae 6.0-9.0%, Herba Artemisiae Anomalae 6.0-9.0%, Spina Gleditsiae 12.0-18.0%, Fructus Hordei Germinatus 2.0-18.0%.
2, the Chinese medicinal capsule of treatment liver-Qi pent-up type gland hyperplasia according to claim 1 is characterized in that the raw material weight percentage ratio described in the Chinese medicinal capsule pharmaceutical formulation of described treatment liver-Qi pent-up type gland hyperplasia is: Olibanum (processed) 3%, Myrrha (processed) 3%, Radix Bupleuri 5%, Thallus Laminariae (Thallus Eckloniae) 5%, Sargassum 5%, Squama Manis 5%, Scolopendra 5%, Pericarpium Citri Reticulatae 6.0%, Radix Paeoniae Rubra 6.0%, the Radix Paeoniae Alba 6.0%, Fructus Toosendan 6.0%, Semen Vaccariae 7.5%, Herba Artemisiae Anomalae 7.5%, Spina Gleditsiae 15%, Fructus Hordei Germinatus 15%.
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| CNB200710017045XA CN100560121C (en) | 2007-08-29 | 2007-08-29 | A kind of Chinese medicinal capsule for the treatment of liver-Qi pent-up type gland hyperplasia |
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Non-Patent Citations (2)
| Title |
|---|
| 乳腺增生病中医治疗近况. 黄海锋，杨志波，肖锦仁.湖南中医学院学报，第16卷第3期. 1996 |
| 乳腺增生病中医治疗近况. 黄海锋，杨志波，肖锦仁.湖南中医学院学报，第16卷第3期. 1996 * |
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