CN100560095C - A kind of compound preparation that contains Amygdaluscommunis L. extract and Folium Ginkgo extract - Google Patents
A kind of compound preparation that contains Amygdaluscommunis L. extract and Folium Ginkgo extract Download PDFInfo
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- CN100560095C CN100560095C CNB2005100427258A CN200510042725A CN100560095C CN 100560095 C CN100560095 C CN 100560095C CN B2005100427258 A CNB2005100427258 A CN B2005100427258A CN 200510042725 A CN200510042725 A CN 200510042725A CN 100560095 C CN100560095 C CN 100560095C
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- extract
- amygdaluscommunis
- folium ginkgo
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Abstract
The present invention is according to modern medical theory, select that to contain the abundant nutrition material and have the Folium Ginkgo extract that free radical eliminates the Amygdaluscommunis L. extract of function and be rich in biological flavone be the medicinal health-care compound preparation that raw material is developed for use, its dosage form comprises dosage forms such as gelatin soft capsule agent, drop, Emulsion, and product has functions such as slow down aging, blood lipid regulation, raising immunologic function, control cardiovascular and cerebrovascular disease and brain-strengthening.
Description
Technical field
Content of the present invention belongs to the preparing technical field of biochemical article, and relating to a kind of Israel and Palestine dawn Fructus Pruni extract and Folium Ginkgo extract is the medicinal health-care preparation of feedstock production.
Background technology
The Amygdaluscommunis L. main product is in the Xinjiang of China area, and the fruit for Rosaceae peach family plant seed crust dawn wood (Amygdaluscommunis L) belongs to nutritious worldwide famous and precious food.The mainly edible kernel of Amygdaluscommunis L., according to check and analysis, fatty oil content is 55%～66% in the Semen Armeniacae Dulcis, and protein content is about 28%, and starch and the content of sugar are about 10%, and contain a small amount of vitamin A, B
1, B
2, needed by human body such as the plain enzyme of E, digestive enzyme, Semen Armeniacae Amarum, Semen Armeniacae Amarum glycoside, calcium, magnesium, sodium, potassium etc. and Fe, Ca, Zn, K, Se trace element, also contain 18 seed amino acids in addition in the Semen Armeniacae Dulcis.For this reason, the Xinjiang uighur ' s culture is generally done tonic food with Amygdaluscommunis L. for a long time, and simultaneously it also is a kind of Uygur medicine, the medicinal function that have cerebral tonic tranquillizing, kidney-tonifying and sperm-producing, loosening bowel to relieve constipation, makes eye bright, is good for the stomach; Amygdaluscommunis L. also can cooperate with other medicines, is used for the treatment of diseases such as hypertension, neurasthenia, skin allergy, tracheitis, children's's rickets.In addition, medical research in recent years shows that Amygdaluscommunis L. has defying age, improves effects such as immunologic function, antioxidation.
China is the abundantest country of Folium Ginkgo resource, accounts for more than 70% of world's total amount.The sixties in last century, Germany scientist at first finds to contain in the Folium Ginkgo effective ingredient of cholesterol reducing, has from then on begun the modern study of Folium Ginkgo pharmacology and application.Scientific research shows that the main effective ingredient in the Folium Ginkgo is flavonoid glycosides and terpene lactones.Ginkgetin comprises ginkegetin, different ginkegetin, bilobetin, Quercetin, kaempferide etc.; the effect of removing oxygen-derived free radicals, protection lipid anti-peroxidation, reducing microvascular permeability, diastole small artery, microcirculation improvement is arranged; it is the choice drug of present western medical treatment cardiovascular and cerebrovascular disease; it can make stiff blood vessel recover elasticity; improve vascular fragility; dilating coronary blood vessel and cerebrovascular prevent the decline of the each several part organ dysfunction that causes because of blood flow is not good.Bilobalide-like also contains lactone B, C and bilobalide etc. except that containing lactone A, wherein lactone B is stronger than lactone A activity, be special platelet activating factor (Plateletactivating factor, PAF) antagonist, have invigorating blood circulation and reduce the effect of serum cholesterol, Folium Ginkgo terpene lactones can be got through the brain neuroblastoma venation, have refresh oneself, the effect of resisting fatigue, memory reinforcing and releasing bronchial muscular spasm, be suitable for diseases such as treatment angina pectoris, cerebral vasospasm, incomplete brain blood supply, hypomnesis and bronchial asthma, alzheimer disease.Modern science man also confirms by zoopery, contain in the Folium Ginkgo multiple property of medicine material all to slow down aging, resist disease and play an important role.
Amygdaluscommunis L. and Folium Ginkgo belong to state approval together be food be again the natural plants of medicine, at present both at home and abroad existing is the equal preparation of single component separately just of preparation of raw material with Amygdaluscommunis L. and Folium Ginkgo, owing to lack rational compatibility, so its control for some disease still can not get a desired effect, this has also influenced the Application and Development of two kinds of raw materials to a certain extent.Understand according to the present patent application people, up to now, this area still finds no the bibliographical information of the compound preparation of preparation with the extract combination of Amygdaluscommunis L. and two kinds of raw materials of Folium Ginkgo.
Summary of the invention
The objective of the invention is to the existing problem of state of the art is solved, and then a kind of medicinal health-care type compound preparation that contains Amygdaluscommunis L. extract and Folium Ginkgo extract that can effectively prevent and treat multiple disease is provided.
Compound preparation of the present invention be the invention designer by to relevant Chinese medicine and pharmacy book concentrate on studies and the basis of medicinal health making food practice on obtain, it is selected for use, and to contain the abundant nutrition material and have the Folium Ginkgo extract that free radical eliminates the Amygdaluscommunis L. extract of function and be rich in biological flavone be basic recipe, be processed into compound preparation by science, the raw material components and the percentage by weight that constitute this compound preparation are:
Amygdaluscommunis L. extract 50%～92% Folium Ginkgo extract 5%～40%
Nutrition accessory agent 1%～10%
Wherein said Amygdaluscommunis L. extract is, and to be raw material with the Amygdaluscommunis L. through cold pressing extraction method or leach extraction method or water extraction extract that the palmitic acid content of making is 4.5%～9.8%, oleic acid content is that 50.8%～77.0% linoleic acid content is 17.3%～44.3% oil preparation Amygdaluscommunis L. extract; Said Folium Ginkgo extract is to be the raw material powdery Folium Ginkgo extract that the Ginkgo total flavones content that makes of extraction separation is 24%～40% routinely, bilobalide content is 6～15%, ginkgoic acid content is lower than 5ppm with the Folium Ginkgo coarse powder, and described nutrition accessory agent is made of a kind of material of selecting in the following material: vitamin E, Fructus Cannabis oil, procyanidin, lycopene, Radix Angelicae Sinensis oil, Rhizoma Chuanxiong oil.
Gelatin soft capsule agent, drop, Emulsion or other dosage form of the dosage form of compound preparation of the present invention for adopting the common process method to make, product have functions such as blood lipid regulation, slow down aging, raising immunologic function, control cardiovascular and cerebrovascular disease and brain-strengthening.In the concrete preparation, look practical situation and can add in preparation also that to account for pure weight of material percentage ratio be 0～5% the edible or medical additive that is made of materials such as opacifier, antioxidant and/or pigments, drop or Emulsion goods contain and account for pure weight of material percentage ratio is 3～5% emulsifying agent and 80%～150% purified water.
The specific embodiment
Following examples are used to illustrate the present invention, but should not be considered as limitation of the present invention.
Embodiment one:
Amygdaluscommunis L. extract 400g Folium Ginkgo extract 100g
Vitamin E 5g
1, the preparation of Amygdaluscommunis L. extract: Semen Armeniacae Dulcis bake and parch to moisture in 125～130 ℃ of getting after selected is about 1.5%, with 30～36Mpa operating pressure it is squeezed in 130～135 ℃ of temperature ranges by pressafiner behind the defibrination, oiliness thing after the squeezing is made with extra care, promptly obtained palmitic acid content and be 4.5%～9.8%, oleic acid content is that 50.8%～77.0% linoleic acid content is 17.3%～44.3% oil preparation Amygdaluscommunis L. extract;
2, the preparation of Folium Ginkgo extract: ginkgo leaf powder is broken into coarse powder, measured the petroleum ether reflux, extract, 1 hour, filtration with 6～8 times, get filtering residue with water logging bubble hour, filter, with filtering residue with 60 ℃ of reflux, extract, of 90% ethanol 3 times, each 3 hours, each ethanol consumption is 5～6 times of primary Folium Ginkgo fine powder, merge each time extracting solution, filter, reclaim ethanol, get crude extract, with H on the crude extract
2-841 macroporous adsorptive resins, be washed to colourless, reuse 70% ethanol elution, reclaim ethanol, the concentrating under reduced pressure drying, powder becomes fine powder, the powdery Folium Ginkgo extract that promptly obtain Ginkgo total flavones content and be 24%～40%, bilobalide content is 6～15%, ginkgoic acid content is lower than 5ppm;
3, will be by 400g Amygdaluscommunis L. extract, 100g Folium Ginkgo extract and the 5g vitamin E mix homogeneously of above two kinds of methods acquisition, with colloid mill or the abundant homogenizing of homogenizer, make 1000 capsules by the soft capsule preparation method, every capsules content 505mg, contain Amygdaluscommunis L. extract 400mg, Folium Ginkgo extract 100mg.
Embodiment two:
Amygdaluscommunis L. extract 730g Folium Ginkgo extract 160g
Vitamin E 10g
The preparation method of Amygdaluscommunis L. extract and Folium Ginkgo extract is with embodiment one, 730g Amygdaluscommunis L. extract, 160g Folium Ginkgo extract and the 10g vitamin E mix homogeneously that will make according to these two kinds of methods, with colloid mill or the abundant homogenizing of homogenizer, make 1000 capsules by the soft capsule preparation method, every capsules content 900mg, contain Amygdaluscommunis L. extract 730mg, Folium Ginkgo extract 160mg.
Embodiment three:
Amygdaluscommunis L. extract 320g Folium Ginkgo extract 90g
Vitamin E 10g
The preparation method of Amygdaluscommunis L. extract and Folium Ginkgo extract is with embodiment one, 320g Amygdaluscommunis L. extract, 90g Folium Ginkgo extract and the 10g vitamin E mix homogeneously that will make according to these two kinds of methods, with colloid mill or the abundant homogenizing of homogenizer, make 1000 capsules by the soft capsule preparation method, every capsules content 460mg, contain Amygdaluscommunis L. extract 320mg, Folium Ginkgo extract 90mg.
Embodiment four:
Amygdaluscommunis L. extract 400g Folium Ginkgo extract 120g
Water 465ml emulsifying agent 15ml
The preparation method of Amygdaluscommunis L. extract and Folium Ginkgo extract is with embodiment one, taking by weighing the 120g Folium Ginkgo extract is dissolved in the suitable quantity of water solution, in addition with 400g Amygdaluscommunis L. extract and 15ml emulsifying agent and all the other aqueous solution, make 1000ml by the Emulsion preparation method, every ml emulsion includes Amygdaluscommunis L. extract 400mg, Folium Ginkgo extract 120mg.
Claims (2)
1, a kind of compound preparation that contains Amygdaluscommunis L. extract and Folium Ginkgo extract is characterized in that it is a compound preparation by the preparation of the formula material of following weight percentage ratio:
Amygdaluscommunis L. extract 50%～92% Folium Ginkgo extract 5%～40%
Nutrition accessory agent 1%～10%
Wherein said Amygdaluscommunis L. extract is be raw material with the Amygdaluscommunis L. through cold pressing extraction method or leach extraction method or water extraction extract that the palmitic acid content of making is 4.5%～9.8%, oleic acid content is 50.8%～77.0%, linoleic acid content is 17.3%～44.3% oiliness Amygdaluscommunis L. extract; Said Folium Ginkgo extract is to be the raw material powdery Folium Ginkgo extract that the Ginkgo total flavones content that makes of extraction separation is 24%～40% routinely, bilobalide content is 6%～15%, ginkgoic acid content is lower than 5ppm with the Folium Ginkgo coarse powder, and described nutrition accessory agent is made of a kind of material of selecting in the following material: vitamin E, Fructus Cannabis oil, procyanidin, lycopene, Radix Angelicae Sinensis oil, Rhizoma Chuanxiong oil.
2, compound preparation according to claim 1, the dosage form that it is characterized in that described compound preparation is gelatin soft capsule agent, drop or the Emulsion that adopts the common process method to make.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100427258A CN100560095C (en) | 2005-05-26 | 2005-05-26 | A kind of compound preparation that contains Amygdaluscommunis L. extract and Folium Ginkgo extract |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100427258A CN100560095C (en) | 2005-05-26 | 2005-05-26 | A kind of compound preparation that contains Amygdaluscommunis L. extract and Folium Ginkgo extract |
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| Publication Number | Publication Date |
|---|---|
| CN1868511A CN1868511A (en) | 2006-11-29 |
| CN100560095C true CN100560095C (en) | 2009-11-18 |
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| CN102907603B (en) * | 2012-10-23 | 2014-08-20 | 新疆中富益健生物科技有限公司 | Composite micro-capsule powder containing badam extractive and preparation method of composite micro-capsule powder |
| CN102920750A (en) * | 2012-11-19 | 2013-02-13 | 温雪 | Health-care compound preparation for nourishing brain and improving eyesight |
| CN103175923B (en) * | 2013-03-12 | 2014-10-15 | 中国科学院新疆理化技术研究所 | Construction method for prunus amygdalus oil fatty acid composition fingerprint spectrum |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1111428A (en) * | 1994-05-05 | 1995-11-08 | 华邦电子股份有限公司 | Mobile executable discrete cosine inversion and reversing integrated circuit processor |
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2005
- 2005-05-26 CN CNB2005100427258A patent/CN100560095C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1111428A (en) * | 1994-05-05 | 1995-11-08 | 华邦电子股份有限公司 | Mobile executable discrete cosine inversion and reversing integrated circuit processor |
Non-Patent Citations (2)
| Title |
|---|
| 新疆巴旦姆种仁高级脂肪酸与氨基酸营养评价. 李颖等.中国食品学报，第4卷第4期. 2004 |
| 新疆巴旦姆种仁高级脂肪酸与氨基酸营养评价. 李颖等.中国食品学报，第4卷第4期. 2004 * |
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Assignee: Xinjiang Zongfuyijian Biotechnology Co., Ltd. Assignor: Wen Yi Contract record no.: 2010650000014 Denomination of invention: Compound prepn. contg. extractive of almond and extractive of ginkgo leaf Granted publication date: 20091118 License type: Exclusive License Open date: 20061129 Record date: 20100804 |
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| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20091118 Termination date: 20110526 |