CN100542610C - 涂指甲及甲周的溶液及其在制备治疗真菌病药品中的用途 - Google Patents
涂指甲及甲周的溶液及其在制备治疗真菌病药品中的用途 Download PDFInfo
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- CN100542610C CN100542610C CNB038212145A CN03821214A CN100542610C CN 100542610 C CN100542610 C CN 100542610C CN B038212145 A CNB038212145 A CN B038212145A CN 03821214 A CN03821214 A CN 03821214A CN 100542610 C CN100542610 C CN 100542610C
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0211023A FR2844197B1 (fr) | 2002-09-05 | 2002-09-05 | Solution pour application ungueale et peri-ungeale |
FR0211023 | 2002-09-05 | ||
US60/411,349 | 2002-09-18 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN2009101641308A Division CN101632627B (zh) | 2002-09-05 | 2003-09-01 | 涂指甲及甲周的溶液 |
Publications (2)
Publication Number | Publication Date |
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CN1703246A CN1703246A (zh) | 2005-11-30 |
CN100542610C true CN100542610C (zh) | 2009-09-23 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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CN2009101641308A Expired - Fee Related CN101632627B (zh) | 2002-09-05 | 2003-09-01 | 涂指甲及甲周的溶液 |
CNB038212145A Expired - Fee Related CN100542610C (zh) | 2002-09-05 | 2003-09-01 | 涂指甲及甲周的溶液及其在制备治疗真菌病药品中的用途 |
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Application Number | Title | Priority Date | Filing Date |
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CN2009101641308A Expired - Fee Related CN101632627B (zh) | 2002-09-05 | 2003-09-01 | 涂指甲及甲周的溶液 |
Country Status (3)
Country | Link |
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CN (2) | CN101632627B (es) |
AR (1) | AR041146A1 (es) |
FR (1) | FR2844197B1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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NZ571818A (en) * | 2006-03-08 | 2011-10-28 | Nihon Nohyaku Co Ltd | External pharmaceutical composition comprising luliconazole and an alpha-hydroxycarboxylic acid such as lactic acid, glycolic acid or malic acid. |
GB2478159A (en) * | 2010-02-26 | 2011-08-31 | Lrc Products | Composition for the treatment of fungal nail infection |
FR2976808B1 (fr) * | 2011-06-22 | 2013-06-28 | Urgo Lab | Composition filmogene et son utilisation pour le traitement de l'herpes |
CN105106179A (zh) * | 2015-08-28 | 2015-12-02 | 江苏福邦药业有限公司 | 一种盐酸阿莫罗芬搽剂的制备方法 |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3666863A (en) * | 1968-03-06 | 1972-05-30 | Medisan Ab | Skin-treating composition and vehicle for skin-treating agents |
US4685911A (en) * | 1984-02-21 | 1987-08-11 | Yamanouchi Pharmaceutical Co., Ltd. | Patch |
WO1987004617A1 (en) * | 1986-02-04 | 1987-08-13 | Sven Moberg | Pharmaceutical compositions containing propylene glycol and/or polyethylene glycol and urea as active main components and use thereof |
CN1048158A (zh) * | 1989-06-23 | 1991-01-02 | 铁汉 | 病甲剥脱剂及其制造方法 |
DE4137544A1 (de) * | 1991-11-12 | 1993-05-13 | Hepper Martin | Antimikrobielle wirkstoffkombination auf der basis von sauerstoff abspaltenden verbindungen |
US5696164A (en) * | 1994-12-22 | 1997-12-09 | Johnson & Johnson Consumer Products, Inc. | Antifungal treatment of nails |
WO1998023152A1 (en) * | 1996-11-26 | 1998-06-04 | Perricone Nicholas V | Stabilized ascorbyl compositions |
US5993790A (en) * | 1997-08-04 | 1999-11-30 | Pedinol Pharmacal Inc. | Nail evulsion compositions and method for evulsing nails and treating nail and nail bed infections |
WO2000015202A2 (de) * | 1998-09-10 | 2000-03-23 | Ipr-Institute For Pharmaceutical Research Ag | Topisch anwendbare mittel |
WO2001049283A1 (de) * | 2000-01-03 | 2001-07-12 | Karl Kraemer | Zubereitungen zur atraumatischen nagelentfernung |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58150509A (ja) * | 1982-03-03 | 1983-09-07 | Taisho Pharmaceut Co Ltd | 白癬症治療剤 |
DE3210138A1 (de) * | 1982-03-19 | 1983-09-22 | Röhm Pharma GmbH, 6100 Darmstadt | Antimykotische, therapeutische zubereitungen auf creme- und salbenbasis |
FR2613227B1 (fr) * | 1987-04-01 | 1990-12-28 | Oreal | Compositions pharmaceutiques a base de nitrate de miconazole ou de nitrate d'econazole dans le traitement des infections fongiques des ongles |
CN1063820A (zh) * | 1991-01-30 | 1992-08-26 | 樊芝芹 | 灰指甲溶解膏的制造方法 |
FR2673537B1 (fr) * | 1991-03-08 | 1993-06-11 | Oreal | Utilisation d'agents de penetration hydrophiles dans les compositions dermatologiques pour le traitement des onychomycoses, et compositions correspondantes. |
NL9401095A (nl) * | 1994-06-30 | 1996-02-01 | Drs Erwin Philip Balthazar Pli | Kosmetisch preparaat voor de verbetering van de eigenschappen van nagels, werkwijze voor het aanbrengen hiervan en toepassing hiervan. |
FR2737406B1 (fr) * | 1995-08-04 | 1997-10-24 | Sederma Sa | Gel a activite physique pour produits cosmetiques |
-
2002
- 2002-09-05 FR FR0211023A patent/FR2844197B1/fr not_active Expired - Fee Related
-
2003
- 2003-09-01 CN CN2009101641308A patent/CN101632627B/zh not_active Expired - Fee Related
- 2003-09-01 CN CNB038212145A patent/CN100542610C/zh not_active Expired - Fee Related
- 2003-09-04 AR ARP030103207A patent/AR041146A1/es unknown
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3666863A (en) * | 1968-03-06 | 1972-05-30 | Medisan Ab | Skin-treating composition and vehicle for skin-treating agents |
US4685911A (en) * | 1984-02-21 | 1987-08-11 | Yamanouchi Pharmaceutical Co., Ltd. | Patch |
WO1987004617A1 (en) * | 1986-02-04 | 1987-08-13 | Sven Moberg | Pharmaceutical compositions containing propylene glycol and/or polyethylene glycol and urea as active main components and use thereof |
CN1048158A (zh) * | 1989-06-23 | 1991-01-02 | 铁汉 | 病甲剥脱剂及其制造方法 |
DE4137544A1 (de) * | 1991-11-12 | 1993-05-13 | Hepper Martin | Antimikrobielle wirkstoffkombination auf der basis von sauerstoff abspaltenden verbindungen |
US5696164A (en) * | 1994-12-22 | 1997-12-09 | Johnson & Johnson Consumer Products, Inc. | Antifungal treatment of nails |
WO1998023152A1 (en) * | 1996-11-26 | 1998-06-04 | Perricone Nicholas V | Stabilized ascorbyl compositions |
US5993790A (en) * | 1997-08-04 | 1999-11-30 | Pedinol Pharmacal Inc. | Nail evulsion compositions and method for evulsing nails and treating nail and nail bed infections |
WO2000015202A2 (de) * | 1998-09-10 | 2000-03-23 | Ipr-Institute For Pharmaceutical Research Ag | Topisch anwendbare mittel |
WO2001049283A1 (de) * | 2000-01-03 | 2001-07-12 | Karl Kraemer | Zubereitungen zur atraumatischen nagelentfernung |
Non-Patent Citations (1)
Title |
---|
Topical and surgical treatment of onychomycosis. COHEN P R ET AL.JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY,Vol.31 No.3. 1994 |
Also Published As
Publication number | Publication date |
---|---|
CN1703246A (zh) | 2005-11-30 |
CN101632627B (zh) | 2013-01-16 |
AR041146A1 (es) | 2005-05-04 |
FR2844197B1 (fr) | 2006-06-23 |
CN101632627A (zh) | 2010-01-27 |
FR2844197A1 (fr) | 2004-03-12 |
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