CN100525817C - Medicinal composition for treating tuberculosis and its preparing process - Google Patents

Medicinal composition for treating tuberculosis and its preparing process Download PDF

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CN100525817C
CN100525817C CNB200710021515XA CN200710021515A CN100525817C CN 100525817 C CN100525817 C CN 100525817C CN B200710021515X A CNB200710021515X A CN B200710021515XA CN 200710021515 A CN200710021515 A CN 200710021515A CN 100525817 C CN100525817 C CN 100525817C
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weight portions
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radix
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tuberculosis
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刘玉正
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Abstract

Disclosed is a pharmaceutical composition for treating tuberculosis which is prepared from the following Chinese medicinal herbs (by weight ratio): Radix Ranunculi Ternati 1-3 weight parts, toad venoms 1-3 weight parts, rhubarb horsetails 1-3 weight parts, fritillary 1-3 weight parts, selfheal 1-3 weight parts, asparagus root 1-3 weight parts. The invention also discloses the process for preparing the pharmaceutical composition.

Description

A kind of treatment tuberculosis composition and method of making the same
Technical field
The present invention relates to a kind of is the pharmaceutical composition of raw material with the Chinese herbal medicine, particularly a kind of treatment tuberculosis compositions; The invention still further relates to this kind treatment tuberculosis preparation of compositions method.
Background technology
In the last few years, short-course chemotherapy is generally adopted in treatment tuberculosis technology and medication both at home and abroad, several antituberculotics are united use, kind surplus the antituberculotics 10 of generally praising highly in the world, comprise isoniazid, rifampicin, pyrazinamide, ethamine tincture alcohol, amine sulfur urine or the like, administration time 6 months is not healed person's reuse 9 months or longer time, and is or else more powerless.These medicines use repeatedly, have just produced drug resistance persister bacterium, and 2/3 tuberculosis patient is in persister bacterium case in the world at present, thereby makes embolic chemotherapy lose effectiveness, makes tuberculosis become incurable disease again.These chemotherapy medicines have damaging action to the patient of liver, renal function difference, to the stomach function is bad stimulation are arranged also, cause obstacles such as feed, digestion, and body constitution weakens, and resistance is poor, and asthenic fire is more vigorous.And for example the streptomycin long term injections has damaging action to the 8th pair of cranial nerve of vestibule, causes side effect such as tinnitus, deafness, giddy, and the relapse rate height can not effect a radical cure.To difficult tuberculosis such as lymphoid tuberculosis, bone tuberculosis, by existing antituberculosis drugs treat, curative effect is poorer, and expense is also quite high.Add whole world increased population, air pollution, pollution of waterhead, a large amount of civilians worker are flowed and tuberculosis are infected and drug resistance patient surge, have brought new pressure for control lungy.
Summary of the invention
Technical problem to be solved by this invention is at the deficiencies in the prior art, provides that a kind of new prescription is simple, compatibility is reasonable, therapeutic effect is treated the tuberculosis compositions significantly.
Another technical problem to be solved by this invention has provided a kind of preparation method of aforementioned pharmaceutical compositions.
Technical problem to be solved by this invention is to realize by following technical scheme.The present invention is a kind of treatment tuberculosis compositions, is characterized in, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 1-3 weight portion Venenum Bufoniss 1-3 weight portions;
Radix Et Rhizoma Rhei 1-3 weight portion Bulbus Fritillariae Uninbracteataes 1-3 weight portions;
Spica Prunellae 1-3 weight portion Fructus Nandinae Domesticaes 1-3 weight portions.
The preferred weight proportioning that the present invention treats each raw material of tuberculosis compositions is,
Radix Ranunculi Ternati 1.5-1.8 weight portion Venenum Bufoniss 1.5-1.8 weight portions;
Radix Et Rhizoma Rhei 1.5-1.8 weight portion Bulbus Fritillariae Uninbracteataes 1.5-1.8 weight portions;
Spica Prunellae 1.5-1.8 weight portion Fructus Nandinae Domesticaes 1.5-1.8 weight portions.
Each raw material that the present invention treats tuberculosis compositions medicament preferably adopts the identical weight proportioning to make, and promptly 6 flavor herbal raw materials such as Radix Ranunculi Ternati were by weight 1: 1: 1: preparation in 1: 1: 1.
The further preferred weight proportioning that the present invention treats each raw material of tuberculosis compositions is,
Radix Ranunculi Ternati 1.67 weight portion Venenum Bufoniss 1.67 weight portions;
Radix Et Rhizoma Rhei 1.67 weight portion Bulbus Fritillariae Uninbracteataes 1.67 weight portions;
Spica Prunellae 1.67 weight portion Fructus Nandinae Domesticaes 1.67 weight portions.
The present invention also provides a kind of as the described treatment tuberculosis of above technical scheme preparation of compositions method, is characterized in that its step is as follows,
(1) get 6 flavor crude drug, after decontamination, dust, pulverize separately are crossed the 100-150 mesh sieve, mix homogeneously;
(2) medicated powder of mix homogeneously is put in the baking box 140-150 ℃ dry sterilization 2-4 hour;
(3) dried medicated powder is made tablet, capsule, unguentum or pill, promptly.
Pharmaceutical composition of the present invention has that tonify deficiency is set upright, the function of detoxicating and resolving stagnation of pathogens, preventing phlegm from forming and stopping coughing, removing the necrotic tissue and promoting granulation, anti-consumptive disease parasite killing, enhancing human body immunity power.Pharmaceutical composition of the present invention is tested disease through cases up to ten thousand are clinical, and to lymphoid tuberculosis, bone tuberculosis, tuberculosis of spine, tuberculosis of spine and tuberculosis of joint, BCG (Bacille Calmette-Guerin) vaccination infects difficult more grade of festering and has peculiar curative effect.Other tuberculosis such as pulmonary tuberculosis, tuberculous pleuritis all there is significant curative effect.It compares characteristics such as having curative effect is good, short treating period with existing antituberculotics such as isoniazid, rifampicin etc., but and not only oral administration but also external, have no side effect, do not produce drug resistance, be difficult for recurrence once curing, be particularly useful for the hepatic and renal function difference and should not take the patient of existing associating antituberculotics, can exempt the hardship of corrective surgery to lymphoid tuberculosis ulceration and tuberculosis of joint, bone tuberculosis etc.
The following clinical experiment that the inventor did.
One, medicine:
The treatment group: medicine of the present invention, provide by inventor's self-control, make powder by the method disclosed in the present, in per 1 gram powder, 6 flavor medicines such as Radix Ranunculi Ternati are 0.167 gram by the same ratio preparation.Usage and dosage: adult every day 3 times, each 1 gram, the child is cut down according to the circumstance.
Matched group: unite medicines such as using isoniazid, streptomycin, rifampicin, or, carry out conventional therapy in conjunction with operation.
Case is selected and efficacy assessment standard formulates by Ministry of Public Health and the regulation and the requirement of promulgation are carried out.
Two, efficacy evaluation.
(1) tuberculosis local symptom and sign;
(2) tuberculosis whole body poisoning symptom;
(3) objective indicator, erythrocyte sedimentation rate, puncture smear and pathology.
Three, clinical experiment situation and curative effect.
(1) clinical experiment treatment lymphoid tuberculosis situation and curative effect.
1, treatment group: 2000 examples, matched group 1200 examples.
2, treatment group medication 3 months, matched group medication 3 months the results are shown in Table 1:
Table 1
Figure C200710021515D00051
3, treatment group medication is after 3 months, and the medication of continuation again of not curing is 3 months, and overall result sees Table 2:
Table 2
Figure C200710021515D00052
4, as can be seen, medicine composite for curing lymphoid tuberculosis of the present invention has special effect, and treatment time is long more, and inefficiency is low more, illustrates that this medicine is comparatively stable to scrofulous curative effect, and suitable extending the period of treatment can improve curative effect by above statistics.
5, toxic and side effects is observed.
Medicinal application of the present invention toxic reaction and side effect occur in none example of lymphoid tuberculosis patient.
(2) clinical experiment treatment tuberculosis of bone and joint curative effect situation.
1, treatment group: 1000 examples, matched group 500 examples.
2, treatment group medication 3 months, matched group medication 3 months the results are shown in Table 3:
Table 3
Figure C200710021515D00061
3, treatment group medication is after 3 months, and the medication of continuation again of not curing is 3 months, and overall result sees Table 4:
Table 4
4, as can be seen, medicine composite for curing tuberculosis of bone and joint of the present invention has remarkable result, and treatment time is long more, and inefficiency is low more, illustrates that this medicine is comparatively stable to the curative effect of tuberculosis of bone and joint, and suitable extending the period of treatment can improve curative effect by above statistics.
5, toxic and side effects is observed.
Medicinal application of the present invention toxic reaction and side effect occur in none example of tuberculosis of bone and joint patient.
(3) clinical experiment treatment pulmonary tuberculosis curative effect situation.
1, treatment group: 1000 examples, matched group 500 examples.
2, treatment group medication 3 months, matched group medication 3 months the results are shown in Table 5:
Table 5
Figure C200710021515D00071
3, treatment group medication is after 3 months, and the medication of continuation again of not curing is 3 months, and overall result sees Table 6:
Table 6
Figure C200710021515D00072
4, as can be seen, medicine composite for curing pulmonary tuberculosis of the present invention has produce effects, and treatment time is long more, and inefficiency is low more, illustrates that this medicine is comparatively stable to phthisical curative effect, and suitable extending the period of treatment can improve curative effect by above statistics.
5, toxic and side effects is observed.
Medicinal application of the present invention toxic reaction and side effect occur in none example of lymphoid tuberculosis patient.
(4) other tuberculosis (as tuberculosis of intestine, tuberculosis of testis, tuberculous pleuritis etc.) curative effect situation is treated in clinical experiment.Example surplus the clinical experiment 500, average medication 3 months, cure rate is 79.2%, total effective rate is 86.4%.
(5) clinical experiment treatment BCG (Bacille Calmette-Guerin) vaccination infects the difficult more person's situation of festering.Adopt the administrated method that combines with external for oral administration, average 10 days left and right sides cure rates 100% of medication.
The specific embodiment
Embodiment 1.A kind of treatment tuberculosis compositions, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 1 weight portion Venenum Bufonis 1 weight portion;
Radix Et Rhizoma Rhei 1 weight portion Bulbus Fritillariae Uninbracteatae 1 weight portion;
Spica Prunellae 1 weight portion Fructus Nandinae Domesticae 1 weight portion.
Technology extracts materials of effective ingredients routinely, adds conventional pharmaceutic adjuvant, makes oral formulations.
Embodiment 2.A kind of treatment tuberculosis compositions, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 3 weight portion Venenum Bufoniss 3 weight portions;
Radix Et Rhizoma Rhei 3 weight portion Bulbus Fritillariae Uninbracteataes 3 weight portions;
Spica Prunellae 3 weight portion Fructus Nandinae Domesticaes 3 weight portions.
Technology extracts materials of effective ingredients routinely, adds conventional pharmaceutic adjuvant, makes capsule.
Embodiment 3.A kind of treatment tuberculosis compositions, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 2 weight portion Venenum Bufoniss 2 weight portions;
Radix Et Rhizoma Rhei 2 weight portion Bulbus Fritillariae Uninbracteataes 2 weight portions;
Spica Prunellae 2 weight portion Fructus Nandinae Domesticaes 2 weight portions.
Technology extracts materials of effective ingredients routinely, adds conventional pharmaceutic adjuvant, makes oral liquid.
Embodiment 4.A kind of treatment tuberculosis compositions, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 1.5 weight portion Venenum Bufoniss 1.5 weight portions;
Radix Et Rhizoma Rhei 1.5 weight portion Bulbus Fritillariae Uninbracteataes 1.5 weight portions;
Spica Prunellae 1.5 weight portion Fructus Nandinae Domesticaes 1.5 weight portions.
Technology extracts materials of effective ingredients routinely, adds conventional pharmaceutic adjuvant, makes tablet.
Embodiment 5.A kind of treatment tuberculosis compositions, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 1.8 weight portion Venenum Bufoniss 1.8 weight portions;
Radix Et Rhizoma Rhei 1.8 weight portion Bulbus Fritillariae Uninbracteataes 1.8 weight portions;
Spica Prunellae 1.8 weight portion Fructus Nandinae Domesticaes 1.8 weight portions.
Technology extracts materials of effective ingredients routinely, adds conventional pharmaceutic adjuvant, makes pill.
Embodiment 6.A kind of treatment tuberculosis compositions, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 2.5 weight portion Venenum Bufoniss 2.5 weight portions;
Radix Et Rhizoma Rhei 2.5 weight portion Bulbus Fritillariae Uninbracteataes 2.5 weight portions;
Spica Prunellae 2.5 weight portion Fructus Nandinae Domesticaes 2.5 weight portions.
Technology extracts materials of effective ingredients routinely, adds conventional pharmaceutic adjuvant, makes powder.
Embodiment 7.A kind of treatment tuberculosis compositions, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 1.67 weight portion Venenum Bufoniss 1.67 weight portions;
Radix Et Rhizoma Rhei 1.67 weight portion Bulbus Fritillariae Uninbracteataes 1.67 weight portions;
Spica Prunellae 1.67 weight portion Fructus Nandinae Domesticaes 1.67 weight portions.
Technology extracts materials of effective ingredients routinely, adds conventional pharmaceutic adjuvant, makes oral formulations.
Embodiment 8.A kind of treatment tuberculosis compositions, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 1 weight portion Venenum Bufonis 2 weight portions;
Radix Et Rhizoma Rhei 3 weight portion Bulbus Fritillariae Uninbracteataes 1 weight portion;
Spica Prunellae 2 weight portion Fructus Nandinae Domesticaes 3 weight portions.
Technology extracts materials of effective ingredients routinely, adds conventional pharmaceutic adjuvant, makes tablet.
Embodiment 9.A kind of treatment tuberculosis compositions, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 1.67 weight portion Venenum Bufoniss 1.67 weight portions;
Radix Et Rhizoma Rhei 1.67 weight portion Bulbus Fritillariae Uninbracteataes 1.67 weight portions;
Spica Prunellae 1.67 weight portion Fructus Nandinae Domesticaes 1.67 weight portions.
Its preparation methods steps is as follows,
(1) get 6 flavor crude drug, after decontamination, dust, pulverize separately are crossed 120 mesh sieves, mix homogeneously;
(2) medicated powder of mix homogeneously was put in the baking box 145 ℃ of dry sterilizations 3 hours;
(3) dried medicated powder is made tablet, promptly.
Embodiment 10.A kind of treatment tuberculosis compositions, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 3 weight portion Venenum Bufoniss 1 weight portion;
Radix Et Rhizoma Rhei 1 weight portion Bulbus Fritillariae Uninbracteatae 3 weight portions;
Spica Prunellae 1 weight portion Fructus Nandinae Domesticae 1 weight portion.
Its preparation methods steps is as follows,
(1) get 6 flavor crude drug, after decontamination, dust, pulverize separately are crossed 100 mesh sieves, mix homogeneously;
(2) medicated powder of mix homogeneously was put in the baking box 140 ℃ of dry sterilizations 2 hours;
(3) dried medicated powder is made capsule, promptly.
Embodiment 11.A kind of treatment tuberculosis compositions, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 2 weight portion Venenum Bufoniss 3 weight portions;
Radix Et Rhizoma Rhei 2 weight portion Bulbus Fritillariae Uninbracteataes 2 weight portions;
Spica Prunellae 3 weight portion Fructus Nandinae Domesticaes 2 weight portions.
Its preparation methods steps is as follows,
(1) get 6 flavor crude drug, after decontamination, dust, pulverize separately are crossed 150 mesh sieves, mix homogeneously;
(2) medicated powder of mix homogeneously was put in the baking box 150 ℃ of dry sterilizations 4 hours;
(3) dried medicated powder is made powder, promptly.
Embodiment 12.A kind of treatment tuberculosis compositions, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 1.5 weight portion Venenum Bufoniss 1.8 weight portions;
Radix Et Rhizoma Rhei 2.5 weight portion Bulbus Fritillariae Uninbracteataes 1.5 weight portions;
Spica Prunellae 1.8 weight portion Fructus Nandinae Domesticaes 2.5 weight portions.
Its preparation methods steps is as follows,
(1) get 6 flavor crude drug, after decontamination, dust, pulverize separately are crossed 130 mesh sieves, mix homogeneously;
(2) medicated powder of mix homogeneously was put in the baking box 142 ℃ of dry sterilizations 2.5 hours;
(3) dried medicated powder is made pill, promptly.
Embodiment 13.A kind of treatment tuberculosis compositions, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 2.5 weight portion Venenum Bufoniss 1.5 weight portions;
Radix Et Rhizoma Rhei 1.5 weight portion Bulbus Fritillariae Uninbracteataes 1.8 weight portions;
Spica Prunellae 2.5 weight portion Fructus Nandinae Domesticaes 1.8 weight portions.
Its preparation methods steps is as follows,
(1) get 6 flavor crude drug, after decontamination, dust, pulverize separately are crossed 140 mesh sieves, mix homogeneously;
(2) medicated powder of mix homogeneously was put in the baking box 148 ℃ of dry sterilizations 3.5 hours;
(3) dried medicated powder is made unguentum, promptly.
Embodiment 14.A kind of treatment tuberculosis compositions, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 1.8 weight portion Venenum Bufoniss 2.5 weight portions;
Radix Et Rhizoma Rhei 1.8 weight portion Bulbus Fritillariae Uninbracteataes 2.5 weight portions;
Spica Prunellae 1.5 weight portion Fructus Nandinae Domesticaes 1.5 weight portions.
Its preparation methods steps is as follows,
(1) get 6 flavor crude drug, after decontamination, dust, pulverize separately are crossed 110 mesh sieves, mix homogeneously;
(2) medicated powder of mix homogeneously was put in the baking box 146 ℃ of dry sterilizations 2.8 hours;
(3) dried medicated powder is made capsule, promptly.
Embodiment 15.A kind of treatment tuberculosis compositions, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 1.2 weight portion Venenum Bufoniss 1.2 weight portions;
Radix Et Rhizoma Rhei 1.2 weight portion Bulbus Fritillariae Uninbracteataes 1.2 weight portions;
Spica Prunellae 1.2 weight portion Fructus Nandinae Domesticaes 1.2 weight portions.
Its preparation methods steps is as follows,
(1) get 6 flavor crude drug, after decontamination, dust, pulverize separately are crossed 120 mesh sieves, mix homogeneously;
(2) medicated powder of mix homogeneously was put in the baking box 145 ℃ of dry sterilizations 3.8 hours;
(3) dried medicated powder is made pill, promptly.
Embodiment 16.A kind of treatment tuberculosis compositions, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 2.8 weight portion Venenum Bufoniss 2.8 weight portions;
Radix Et Rhizoma Rhei 2.8 weight portion Bulbus Fritillariae Uninbracteataes 2.8 weight portions;
Spica Prunellae 2.8 weight portion Fructus Nandinae Domesticaes 2.8 weight portions.
Its preparation methods steps is as follows,
(1) get 6 flavor crude drug, after decontamination, dust, pulverize separately are crossed 120 mesh sieves, mix homogeneously;
(2) medicated powder of mix homogeneously was put in the baking box 145 ℃ of dry sterilizations 3 hours;
(3) dried medicated powder is made tablet, promptly.
Embodiment 17.A kind of treatment tuberculosis compositions, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 1.3 weight portion Venenum Bufoniss 1.1 weight portions;
Radix Et Rhizoma Rhei 1.6 weight portion Bulbus Fritillariae Uninbracteataes 1.7 weight portions;
Spica Prunellae 1.7 weight portion Fructus Nandinae Domesticaes 1.4 weight portions.
Technology extracts materials of effective ingredients routinely, adds conventional pharmaceutic adjuvant, makes injection.
Embodiment 18.A kind of treatment tuberculosis compositions, it is the medicament of being made by the herbal raw material of following weight proportion,
Radix Ranunculi Ternati 2.7 weight portion Venenum Bufoniss 2.6 weight portions;
Radix Et Rhizoma Rhei 1.3 weight portion Bulbus Fritillariae Uninbracteataes 1.9 weight portions;
Spica Prunellae 1.1 weight portion Fructus Nandinae Domesticaes 2.6 weight portions.
Technology extracts materials of effective ingredients routinely, adds conventional pharmaceutic adjuvant, makes drop pill.

Claims (5)

1, a kind of treatment tuberculosis compositions is characterized in that, it is the medicament of being made by the herbal raw material of following weight proportion:
Radix Ranunculi Ternati 1-3 weight portions; Venenum Bufonis 1-3 weight portions;
Radix Et Rhizoma Rhei 1-3 weight portions; Bulbus Fritillariae Uninbracteatae 1-3 weight portions;
Spica Prunellae 1-3 weight portions; Fructus Nandinae Domesticae 1-3 weight portions.
2, a kind of treatment tuberculosis compositions according to claim 1 is characterized in that the weight proportion of each raw material is:
Radix Ranunculi Ternati 1.5-1.8 weight portions; Venenum Bufonis 1.5-1.8 weight portions;
Radix Et Rhizoma Rhei 1.5-1.8 weight portions; Bulbus Fritillariae Uninbracteatae 1.5-1.8 weight portions;
Spica Prunellae 1.5-1.8 weight portions; Fructus Nandinae Domesticae 1.5-1.8 weight portions.
3, a kind of treatment tuberculosis compositions according to claim 1 is characterized in that, each raw material of medicament adopts the identical weight proportioning to make.
4, a kind of treatment tuberculosis compositions according to claim 1 is characterized in that the weight proportion of each raw material is:
Radix Ranunculi Ternati 1.67 weight portions; Venenum Bufonis 1.67 weight portions;
Radix Et Rhizoma Rhei 1.67 weight portions; Bulbus Fritillariae Uninbracteatae 1.67 weight portions;
Spica Prunellae 1.67 weight portions; Fructus Nandinae Domesticae 1.67 weight portions.
5, a kind ofly it is characterized in that as claim 1 or 2 or 3 or 4 described treatment tuberculosis preparation of compositions methods its step is as follows,
(1) get 6 flavor crude drug, after decontamination, dust, pulverize separately are crossed the 100-150 mesh sieve, mix homogeneously;
(2) medicated powder of mix homogeneously is put in the baking box 140-150 ℃ dry sterilization 2-4 hour;
(3) dried medicated powder is made tablet, capsule, powder, unguentum or pill, promptly.
CNB200710021515XA 2007-04-18 2007-04-18 Medicinal composition for treating tuberculosis and its preparing process Expired - Fee Related CN100525817C (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103316219B (en) * 2013-07-01 2015-08-12 郝燕琴 One treats phthisical Chinese medicine preparation and preparation method thereof
CN103623233B (en) * 2013-12-16 2015-10-14 赵龙山 One treats phthisical herb liquid
CN103705792B (en) * 2014-01-17 2016-02-10 华北理工大学 One treats phthisical Traditional Chinese medicine composition paste and preparation method thereof
CN104825960A (en) * 2015-05-06 2015-08-12 陈洪芳 Traditional Chinese medicine for treating pulmonary tuberculosis and preparation method thereof
CN110201091A (en) * 2019-07-06 2019-09-06 高艳萍 It is a kind of to treat tuberculosis composition

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