CN100525747C - Process for preparing Tibetan medicine soup promoting medicine composition - Google Patents
Process for preparing Tibetan medicine soup promoting medicine composition Download PDFInfo
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- CN100525747C CN100525747C CNB200310118921XA CN200310118921A CN100525747C CN 100525747 C CN100525747 C CN 100525747C CN B200310118921X A CNB200310118921X A CN B200310118921XA CN 200310118921 A CN200310118921 A CN 200310118921A CN 100525747 C CN100525747 C CN 100525747C
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- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of Tibetan Cuitang medicine composition. The well-known material for Tibetan Cuitang medicine composition in routine amount is water extracted for several times; the merged extracted liquid is decompression concentrated to form concentrated liquid; and medicinal supplementary material is added into the concentrated liquid to prepare granule or other solid preparation, or the concentrated liquid is spray dried to form medicine powder, or the medicine is mixed with concentrated liquid and then prepared into granule or other solid preparation. The present invention has stable preparation process, high and controllable equipment and high curative effect.
Description
Technical field
The present invention relates to a kind of known Tibetan medicine and urge the new preparation process of decoction compositions.
Background technology
Several ancient civilized countries are arranged in the world, comprise China, India, Egypt, Greece etc., in these ancient civilized countries, the people have created time-honored culture more, comprise medical science.Tibetanmedicine in the Chinese medicine, it is with a long history, and is abundant in content, and system, theoretical uniqueness are complete medical system that is only second to Han nationality's medical science.As far back as B.C., Tibetan people in the process of struggling with disease, just have realized that moving, plant, some parts of mineral has the effect of treatment human body diseases, through accumulation in several thousand, formed the complete theoretical system of a cover, and instructed clinical effectively.Though Tibetan medicine's theory is complete, unique, because the influence of region, environment, living habit, the dosage form in the tibetan traditional medicine preparation has powder, decoction, pill, unguentum, medicine oil, medicated wine, drop etc. at present, but great majority are powder.
Wherein, powder is the powder preparation that multiple medicine is mixed and made into.Decoction is for after the medicine decocting boils, and the leaching medicine juice is for for oral administration.
Pill means that fine drug powder adds the spheroidal preparation that suitable binding agent is made.
Unguentum is meant with the medicine process and selects, and removes clean impurity, adds water logging and boils, the dosage form that is smelt.
Medicated wine divides Mel medicated wine, folk prescription medicated wine and compound recipe medicated wine.
Most powders, pill mostly are the crude drug powder and are used as medicine, and it exists dose big, and a traditional Tibetan medicine watered pill ball is big and hard, rough surface, disintegration is long, the hygiology index is defective etc. " four big pertinacious diseases ", and mouthfeel is poor, produce effects slow, be unfavorable for deficiency such as treatment.Traditional decoction decocts with the preceding water that needs, and uses extremely inconvenience and inconvenience to carry.
Summary of the invention
The objective of the invention is the traditional preparation process technology of urging the soup ball, the new preparation method of inventing in conjunction with new technique in order to change.
Purpose of the present invention can realize by following measure:
The nine flavor medical materials such as Fructus Terminaliae Billericae, Phlomis kawaguchii Murata of Tibetan medicine being urged Fructus Chebulae, Fructus Phyllanthi, the enucleation of Radix Polygoni aubertii, Fructus Hedychii Spicati, the enucleation of Caulis Rubi corchorifolii, the peeling of known raw material Radix Inulae, Radix Inulae, peeling, the heart of decoction compositions are handled in order to method down: (1) will carry out pretreated above-mentioned raw materials crude drug and add water, the water yield that is added is 5～20 times of natural plant crude drugs gross weight, carry out heating extraction 0.5～24 hour first time to the temperature of boiling at 70 ℃, filter, obtain extracting solution and medicinal residues for the first time for the first time; (2) add water to the first time in the medicinal residues, the water yield that is added is 3～15 times of natural plant crude drugs gross weight, carries out heating extraction 0.5～10 hour second time to the temperature of boiling at 70 ℃, filters, and obtains extracting solution and medicinal residues for the second time for the second time; (3) add water to the second time in the medicinal residues, the water yield that is added is 3～10 times of natural plant crude drugs gross weight, carries out for the third time heating extraction to the temperature of boiling 0.5～7 hour at 70 ℃, filters, and obtains extracting solution and medicinal residues for the third time for the third time; (4) merge first, second and third time extracting solution; (5) extracting solution that is combined carries out concentrating under reduced pressure and becomes concentrated solution; (6) will add pharmaceutic adjuvant in the concentrated solution, be prepared into granule or other solid preparations.Or concentrated solution carried out spray drying, make it become medicated powder; Or the adding concentrated solution is made granule or other solid preparations in aforementioned medicated powder.When wherein concentrated solution being spray dried to medicated powder, be atomization gas with the water vapour, atomize that the pressure of atomization gas is 0.1～1Mpa, exsiccant temperature is 60 ℃～500 ℃; Water content is 0.1～10% of a powdery medicine gross weight in the prepared powdery medicated powder; Or when wherein concentrated medicament being spray dried to medicated powder, with centrifugal energy nozzle concentrated medicament is sprayed in the hot air chamber, be drying medium to be heated to 60 ℃～400 ℃ heated drying air, carry out the transient heat exchange, and be dried to medicated powder; The temperature that concentrated solution is spray dried to medicated powder is 80 ℃～400 ℃.
For the first time added water in the described step (1) in carrying out pretreated natural plant raw material, the water yield that is added is 5～10 times of former gross weights of natural plant crude drugs, carries out heating extraction 1.5～5 hours first time to the temperature of boiling at 70 ℃.
The pressure of the extracting solution in the described step (5) behind the concentrating under reduced pressure united extraction is 0.01～0.09Mpa; Extracting solution temperature after concentrating under reduced pressure merges is 40 ℃～90 ℃; Extracting solution temperature after being concentrated into 0.1～0.8 times of extracting solution after the merging or concentrating under reduced pressure after the extracting solution decompression and merging is 60 ℃～90 ℃; Be concentrated into 0.1～0.5 times of extracting solution after the merging after the extracting solution decompression.
Pharmaceutic adjuvant and/or carrier in the described step (6) are meant diluent required in the forming process, disintegrating agent, wetting agent and fluidizer etc.
The solid preparation that described step (6) is made is meant solid dosage formss such as sheet, ball, capsule.
The preparation method of described natural drug further comprises to adding water in the medicinal residues for the third time, the water yield that is added is 3～10 times that natural plant crude drugs must be measured, carry out the 4th heating extraction to the temperature of boiling 0.5～5 hour at 70 ℃, filter, obtain the 4th extracting solution and the 4th medicinal residues; Extract so repeatedly, until at last medicinal residues being discarded; Merge each time extracting solution, behind the concentrating under reduced pressure, be spray dried to the powdery medicine.
Purpose of the present invention also can realize by following measure:
A kind of Tibetan medicine is urged the preparation method of decoction compositions, urge raw material Radix Inulae, Radix Inulae, peeling, the Caulis Rubi corchorifolii of the heart, the Radix Polygoni aubertii of peeling, Fructus Hedychii Spicati, the Fructus Chebulae of enucleation, Fructus Phyllanthi, the Fructus Terminaliae Billericae of enucleation, the Phlomis kawaguchii Murata of decoction compositions to adopt following step preparation by its known consumption known Tibetan medicine: added water for the first time in carrying out pretreated natural plant crude drugs, the water yield that is added is 5～15 times of natural plant crude drugs raw material gross weight; Carry out heating extraction 1.5～6 hours first time to the temperature of boiling at 70 ℃, the concentrating under reduced pressure extracting solution, its pressure is 0.01～0.09Mpa, the temperature of concentrating under reduced pressure is 60 ℃～90 ℃, is evaporated to 0.1～0.5 times of extracting solution of merging, when its concentrated medicament is carried out spray drying, with the water vapour is atomization gas, atomize, the pressure of atomization gas is 0.1～1.0Mpa, and exsiccant temperature is 60 ℃～500 ℃; In addition, when carrying out spray drying, also concentrated medicament can be sprayed in the hot air chamber by the centrifugal spray head, be drying medium to be heated to 60 ℃～400 ℃ hot-air, carries out the transient heat exchange, and be dried to the powdery medicine.
The advantage of method of the present invention is as follows:
1, the stable preparation process of the medicine made than prior art of the solid dosage forms product made of method of the present invention, quality is high and quality controllable, help guaranteeing curative effect, in quality testing, can set examination criteria, medicament contg is measured and the detection of effective ingredient, to guarantee the quality of Tibetan medicine solid preparation.
2, because method of the present invention has adopted modern spray drying technology, not only keep the active substance in the natural plant crude drugs and the active ingredient of medical material effectively, improved the ratio of crude drug composition again greatly, make curative effect better, the disintegration time of solid preparation shortens greatly simultaneously, onset is rapider, and prolongs the medicine resting period greatly, is convenient to take and carry.
3, the solid dosage forms made of method of the present invention need not added the stabilizing agent of any chemosynthesis, thus safe in utilization, only need during use get final product with water delivery service.The present invention makes the production of Tibetan medicine realize industrialization by the reform of dosage form, and product also can be transported for long-distance and enter the international market towards huge numbers of families' patient.
Concrete embodiment
The invention provides and urge with being inconvenient to take the Tibetan medicine that needs to decoct that the decoction compositions is made taking convenience, the method for the dosage form that is easy to carry about with one, to carry out pretreated Tibetan medicine urges the known raw material crude drug of decoction compositions to place the container of extraction, add entry, the water yield that is added is 5～20 times of natural plant crude drugs gross weight, carry out heating extraction 0.5～24 hour first time to the temperature of boiling at 70 ℃, filter, obtain extracting solution and medicinal residues for the first time for the first time; Add water to the first time in the medicinal residues, the water yield that is added is 3～15 times of natural plant crude drugs gross weight, 70 ℃ to boil temperature under carry out heating extraction 0.5～10 hour second time, filter, obtain extracting solution and medicinal residues for the second time for the second time; Add water to the second time in the medicinal residues, the water yield that is added is 3～10 times of natural plant crude drugs gross weight, carries out for the third time heating extraction to the temperature of boiling 0.5～7 hour at 70 ℃, filters, and obtains extracting solution and medicinal residues for the third time for the third time; Merge first, second and third extracting solution, the extracting solution that is combined carries out concentrating under reduced pressure, makes it become concentrated solution (leaving and taking standby in right amount), again all the other concentrated solutions is carried out spray drying, makes it become medicated powder.Aforementioned medicated powder with after aforementioned dense medicine juice with viscosity or binding agent fully mix, is added other required pharmaceutic adjuvants, further make solid dosage forms.
Wherein, the pressure of the extracting solution behind the described concentrating under reduced pressure united extraction is that 0.01～0.09Mpa is good; Extracting solution temperature after concentrating under reduced pressure merges is 60 ℃～90 ℃;
Be concentrated into 0.1～0.5 times of extracting solution after the merging after the extracting solution decompression, become dense medicine juice;
When concentrated solution is spray dried to medicated powder, be atomization gas with the water vapour, atomize that the pressure of atomization gas is 0.1～1Mpa, exsiccant temperature is 60 ℃～500 ℃;
Water content is 0.1～10% of a powdery medicine gross weight in the prepared powdery medicated powder.
The pretreatment of said natural plant crude drugs raw material is meant: selects up-to-standard natural plant crude drugs as raw material, washes airing, be cut into the fragment of 5～20mm, and better with the fragment that is cut into 5～10mm.The medical material that has also will soak, so that utilize the stripping of medicine during heating extraction, the length of soak time is looked the character of medical material but those of ordinary skills should know.For example, the medicine that has only soaked 30～40 minutes, and the needs that have soaked 12～24 hours.Sometimes soak water and can be used as the part of amount of water for the first time.Above-mentioned these preprocess methods are that those of ordinary skills should know.Added water can be tap water, drink well water, the comparatively purified water of treated mistakes such as also available distilled water, ion exchange water during pretreatment.
But the pharmaceutic adjuvant with viscosity of used hyoscine can be binding agents such as starch slurry, dextrin slurry, ethanol syrup; Strong binding agent such as sucrose slurry, liquid glucose, maltose, refined honey, mucialga of arabic gummy, gelatine size; Dry adhesive such as amylum pregelatinisatum, dextrin; CMC-Na (sodium carboxymethyl cellulose), L-HPC (low-substituted hydroxypropyl cellulose), HPMC (hydroxypropyl emthylcellulose), MCC (microcrystalline Cellulose), PVP (polyvinylpyrrolidone), PEG binding agents such as (Polyethylene Glycol).
During use, it is 8%～15% that starch slurry is generally selected concentration for use, is the most frequently used with 10%; The viscosity of dextrin slurry is a bit larger tham starch slurry, and generally selecting concentration for use is 10%～20%, is the most frequently used with 15%; Also can be made into 10% dextrin slurry and mix use with 10% starch slurry; The ethanol syrup is tried out in the ethanol (60% below) of low concentration, and viscosity is strong excessively during granulation, can't molding, and during with the ethanol of higher concentration, and again easily under the loose situation about splitting of generation.Ethanol is syrupy to be formulated as: Saccharum Sinensis Roxb. 5kg+ water 3L → (heating) dissolving ethanol 10L → mixing (filtering in case of necessity).
The sucrose slurry is applicable to that general working concentration was 50%～70% (g/g) when fibroid was loosened than strong or quality; The medicine that liquid glucose is suitable for is similar to sucrose, and typical concentrations is 25% and 50%; The viscosity of maltose and refined honey is all very strong.Can be used for fibroid reach by force quality loosen, when being easy to generate crackle.
Mucialga of arabic gummy, gelatine size are applicable to easily loose or require the big solid dosage forms of hardness.Typical concentrations is that mucialga of arabic gummy is 10%～20%, and gelatine size is 10%～15%, also can add 20% gelatine size (10: 1) in starch slurry.
Dry adhesive such as amylum pregelatinisatum, dextrin has dry adhesion preferably; Dextrin can produce viscosity and use as dry adhesive after the moistening.
CMC-Na (sodium carboxymethyl cellulose), L-HPC (low-substituted hydroxypropyl cellulose), HPMC (hydroxypropyl emthylcellulose), MCC (microcrystalline Cellulose), PVP (polyvinylpyrrolidone), PEG binding agents such as (Polyethylene Glycol).The CMC-Na typical concentrations is 1%～2% aqueous solution, also can be directly as dry adhesive; L-HPC is cellulosic hydroxypropyl ether, and typical concentrations is 1～8%, and HPMC is that cellulosic methyl hydroxypropyl etherificate thing, MCC belong to semisynthetic macromolecular compound, has stronger dry adhesion; PVP is a high molecular polymer, and its aqueous solution of 5%～25% has different viscosity; PEG is the general name of glycol molecule polymer, can select for use PEG-4000 directly to mix with principal agent under drying regime, and general consumption is 15%～20%, is commonly used with 18% again.
All the other used pharmaceutic adjuvants can have disintegrating agent, are to dissolve the adjuvant that adds for solid preparation being collapsed rapidly loosing in gastrointestinal.Can be dry starch, carboxymethyl starch, carboxymethyl starch sodium (CMS-Na), be most widely used wherein with dry starch, with before should be in advance dry at 100 ℃～105 ℃, make water content between 8%～10%, consumption is generally 5%～20% of powdery medicine gross weight, is best with 8%～15% again; Carboxymethyl starch is one of effective disintegrating agent in the starch derivatives, and volume is inflatable 200～300 times behind the chance water, and disintegrating property is good; CMS-Na is the ion type starch derivant, needs to use after cold bubbly water rises; Be added on outward with 2%CMS-Na that the disintegrate effect is good in the powdery medicine; Also can be the effervescent of konjaku powder, magnesium trisilicate (2MgO.SiO.H2O), citric acid or tartaric acid and NaHCO3 mixture, its principle plays acid-base reaction when meeting water and produces the CO2 bubble and make disintegration of tablet.Directly contact with acid for fear of NaHCO3, increase stability, adopt Polyethylene Glycol microcapsule packaging method that NaHCO3 is wrapped up]; Also can use surfactants such as tween 80, sodium laurylsulfate, stearyl alcohol sodium sulfonate, can reduce the interfacial tension between moisture and the medicine, promote moisture to infiltrate in the medicine, make the medicine quick humidification and disintegrate takes place.Press 0.25% tween 80 and 5% of powdery medicine total amount, 10% dried starch use.In addition, hydroxyl starch propionate (HPS), MCC, HPMC, L-HPC also can be used as disintegrating agent.
In order to reduce the frictional force of powdery medicine in the forming process or powdery medicine and equipment room, can add lubricant and fluidizer sometimes.Lubricant can be that pharmaceutical production at present such as magnesium stearate, Pulvis Talci, water miscible sodium laurylsulfate, magnesium stearate, Pulvis Talci is generally used, wherein with magnesium stearate at first selecting for use; Liquid Paraffin, Polyethylene Glycol, boric acid etc. also can use.
Described binding agent is meant the pharmaceutic adjuvant with viscosity; Other pharmaceutic adjuvants are meant diluent required in the forming process, disintegrating agent, wetting agent and fluidizer etc.;
The solid preparation of making is meant solid dosage formss such as sheet, ball, capsule.
Because being difficult to lixiviate, the effective ingredient of the vegetable drug that has comes out, need be to adding water in the medicinal residues for the third time, the water yield that is added is 3～10 times that natural plant crude drugs must be measured, carrying out the 4th heating extraction to the temperature of boiling 0.5～5 hour at 70 ℃, filter, obtain the 4th extracting solution and the 4th medicinal residues; The medical material that has even need carry out the 5th, six, seven time and extract depends on the needs, and at last medicinal residues is discarded; Merge first, second, third and fourth time extracting solution or merge first, second, third and fourth, five ... extracting solution behind the concentrating under reduced pressure, is spray dried to the powdery medicine.
The effective ingredient of the natural plant crude drugs that has is easy to by water extraction, also can only carry out the first time and extract or second extraction, and the number of times of extraction is decided on vegetable drug.
Described Tibetan medicine urges the preparation method of decoction compositions to comprise the steps: to urge in the known raw material natural plant crude drugs of decoction compositions and to add water for the first time to carrying out pretreated Tibetan medicine, the water yield that is added is 5～15 times of natural plant crude drugs raw material gross weight, be that 5～10 times of natural plant crude drugs gross weight are advisable with the water yield that is added again, carry out first time heating extraction 1.5～6 hours to the temperature of boiling for good at 70 ℃, during concentrating under reduced pressure, its pressure is 0.01～0.09Mpa, again with 0.01～0.06Mpa for well, the temperature of concentrating under reduced pressure is 60 ℃～90 ℃, be evaporated to 0.1～0.5 times of extracting solution of merging, when its concentrated medicament is carried out spray drying, with the water vapour is atomization gas, atomize, the pressure of atomization gas is 0.1～1.0Mpa, exsiccant temperature is 60 ℃～500 ℃, again with 200 ℃～400 ℃ for well, in addition, when carrying out spray drying, also concentrated medicament can be sprayed in the hot air chamber by the centrifugal spray head, to be heated to 60 ℃～400 ℃ hot-air is drying medium, carry out the transient heat exchange, and be dried to the powdery medicine.
But the pharmaceutic adjuvant with viscosity of used hyoscine can be binding agents such as starch slurry, dextrin slurry, ethanol syrup; Strong binding agent such as sucrose slurry, liquid glucose, maltose, refined honey, mucialga of arabic gummy, gelatine size; Dry adhesive such as amylum pregelatinisatum, dextrin; CMC-Na (sodium carboxymethyl cellulose), L-HPC (low-substituted hydroxypropyl cellulose), HPMC (hydroxypropyl emthylcellulose), MCC (microcrystalline Cellulose), PVP (polyvinylpyrrolidone), PEG binding agents such as (Polyethylene Glycol).
During use, it is 8%～15% that starch slurry is generally selected concentration for use, is the most frequently used with 10%; The viscosity of dextrin slurry is a bit larger tham starch slurry, and generally selecting concentration for use is 10%～20%, is the most frequently used with 15%; Also can be made into 10% dextrin slurry and mix use with 10% starch slurry; The ethanol syrup is tried out in the ethanol (60% below) of low concentration, and viscosity is strong excessively during granulation, can't molding, and during with the ethanol of higher concentration, and again easily under the loose situation about splitting of generation.Ethanol is syrupy to be formulated as: Saccharum Sinensis Roxb. 5kg+ water 3L → (heating) dissolving ethanol 10L → mixing (filtering in case of necessity);
The sucrose slurry is applicable to that general working concentration was 50%～70% (g/g) when fibroid was loosened than strong or quality; The medicine that liquid glucose is suitable for is similar to sucrose, and typical concentrations is 25% and 50%; The viscosity of maltose and refined honey is all very strong.Can be used for fibroid reach by force quality loosen, when being easy to generate crackle;
Mucialga of arabic gummy, gelatine size are applicable to easily loose or require the big solid dosage forms of hardness.Typical concentrations is that mucialga of arabic gummy is 10%～20%, and gelatine size is 10%～15%, also can add 20% gelatine size (10: 1) in starch slurry;
Dry adhesive such as amylum pregelatinisatum, dextrin has dry adhesion preferably; Dextrin can produce viscosity and use as dry adhesive after the moistening;
CMC-Na (sodium carboxymethyl cellulose), L-HPC (the low carboxy-propyl cellulose that replaces), HPMC (hydroxypropyl emthylcellulose), MCC (microcrystalline Cellulose), PVP (polyvinylpyrrolidone), PEG binding agents such as (Polyethylene Glycol).The CMC-Na typical concentrations is 1%～2% aqueous solution, also can be directly as dry adhesive; L-HPC is cellulosic hydroxypropyl ether, and typical concentrations is 1～8%, and HPMC is that cellulosic methyl hydroxypropyl etherificate thing, MCC belong to semisynthetic macromolecular compound, has stronger dry adhesion; PVP is a high molecular polymer, and its aqueous solution of 5%～25% has different viscosity; PEG is the general name of glycol molecule polymer, can select for use PEG-4000 directly to mix with principal agent under drying regime, and general consumption is 15%～20%, is commonly used with 18% again.
All the other used pharmaceutic adjuvants can have disintegrating agent, are to dissolve the adjuvant that adds for solid preparation being collapsed rapidly loosing in gastrointestinal.Can be dry starch, carboxymethyl starch, carboxymethyl starch sodium (CMS-Na), be most widely used wherein with dry starch, with before should be in advance dry at 100 ℃～105 ℃, make water content between 8%～10%, consumption is generally 5%～20% of powdery medicine gross weight, is best with 8%～15% again; Carboxymethyl starch is one of effective disintegrating agent in the starch derivatives, and volume is inflatable 200～300 times behind the chance water, and disintegrating property is good; CMS-Na is the ion type starch derivant, needs to use after cold bubbly water rises; Be added on outward with 2%CMS-Na that the disintegrate effect is good in the powdery medicine; Also can be the effervescent of konjaku powder, magnesium trisilicate (2MgO.SiO.H2O), citric acid or tartaric acid and NaHCO3 mixture, its principle plays acid-base reaction when meeting water and produces the CO2 bubble and make disintegration of tablet.Directly contact with acid for fear of NaHCO3, increase stability, adopt Polyethylene Glycol microcapsule packaging method that NaHCO3 is wrapped up]; Also can use surfactants such as tween 80, sodium laurylsulfate, stearyl alcohol sodium sulfonate, can reduce the interfacial tension between moisture and the medicine, promote moisture to infiltrate in the medicine, make the medicine quick humidification and disintegrate takes place.Press 0.25% tween 80 and 5% of powdery medicine total amount, 10% dried starch use.In addition, hydroxyl starch propionate (HPS), MCC, HPMC, L-HPC also can be used as disintegrating agent.
In order to reduce the frictional force of powdery medicine in the forming process or powdery medicine and equipment room, sometimes can add lubricant and fluidizer lubricant, can be that pharmaceutical production at present such as magnesium stearate, Pulvis Talci, water miscible sodium laurylsulfate, magnesium stearate, Pulvis Talci is generally used, wherein with magnesium stearate at first selecting for use; Liquid Paraffin, Polyethylene Glycol, boric acid etc. also can use.
Can make the not solid pharmaceutical dosage form of disease of the same race of treatment with different vegetable drug combinations according to different diseases with method of the present invention.
Use method of the present invention, every or ball or capsule etc. contain effective composition, substantially exceed the content of the active ingredient of crude drug in the medical solid preparation that the method for prior art makes.
The solid dosage forms that contains the natural medicinal plant active ingredient that said method is prepared can be in disk shape or special-shaped lamellar or ball shape or special-shaped ball shape or the capsules such as the gastric solubleness of packing into, enteric or powder, granule.
The method of above-mentioned preparation can describe in detail by following specific embodiment:
Tibetan medicine is urged the known raw material Radix Inulae of decoction compositions, Radix Inulae, stem of Fructus Rubi corchorifolii Immaturus (peeling, the heart), Radix Polygoni aubertii (peeling), Fructus Hedychii Spicati, Fructus Chebulae's (enucleation), Fructus Phyllanthi, Fructus Terminaliae Billericae (enucleation), Phlomis kawaguchii Murata, with above nine herbal medicines, clean, section, the water that adds 10 times of amounts, decoct to boiling, continue to decoct 60 minutes, filter, obtain extracting solution and medicinal residues for the first time for the first time, the water that adds 8 times of amounts in first time medicinal residues boils the back and continues to decoct 45 minutes, filters, obtain extracting solution and medicinal residues for the second time for the second time, merge filtrate and filtrate for the first time for the second time, the filtrate that merges is carried out concentrating under reduced pressure, standby.
1, will make powder after the concentrated solution spray drying;
2, be concentrated into thick paste after, add supplementary product starch, Icing Sugar is an amount of, makes granule.
3, with adding binding agent (dextrin, ethanol) in the granule in the method 2 in right amount, on tablet machine, make tablet.
4, the powder in the method 1 is added binding agent, make pill.
5, the granule in the method 2 is incapsulated, make capsule.
Claims (5)
1, a kind of Tibetan medicine is urged the preparation method of decoction compositions, and the pharmacodynamic raw materials of employing is the pharmacodynamic raw materials that known Tibetan medicine is urged the soup ball, and concrete kind is as follows:
The Radix Polygoni aubertii of the Caulis Rubi corchorifolii peeling of the peeling of Radix Inulae Radix Inulae, the heart
The Fructus Terminaliae Billericae Phlomis kawaguchii Murata of Fructus Chebulae's Fructus Phyllanthi enucleation of Fructus Hedychii Spicati enucleation
Urge the proportioning of the pharmacodynamic raw materials of soup ball to adopt following step preparation by known Tibetan medicine:
(2) will carry out pretreated above-mentioned crude drug raw material and add water, the water yield that is added is 5～20 times of natural plant crude drugs gross weight, carry out heating extraction 0.5～24 hour first time to the temperature of boiling at 70 ℃, filter, obtain extracting solution and medicinal residues for the first time for the first time;
(2) add water to the first time in the medicinal residues, the water yield that is added is 3～15 times of natural plant crude drugs gross weight, carries out heating extraction 0.5～10 hour second time to the temperature of boiling at 70 ℃, filters, and obtains extracting solution and medicinal residues for the second time for the second time;
(3) add water to the second time in the medicinal residues, the water yield that is added is 3～10 times of natural plant crude drugs gross weight, carries out for the third time heating extraction to the temperature of boiling 0.5～7 hour at 70 ℃, filters, and obtains extracting solution and medicinal residues for the third time for the third time;
(4) merge first, second and third time extracting solution;
(5) extracting solution that is combined carries out concentrating under reduced pressure and becomes concentrated solution;
(6) concentrated solution is carried out spray drying, make it become medicated powder; When wherein concentrated solution being spray dried to medicated powder, be atomization gas with the water vapour, atomize that the pressure of atomization gas is 0.1～1Mpa, exsiccant temperature is 60 ℃～500 ℃; Water content is 0.1～10% of a powdery medicine gross weight in the prepared powdery medicated powder; Or when wherein concentrated medicament being spray dried to medicated powder, with centrifugal energy nozzle concentrated medicament is sprayed in the hot air chamber, be drying medium to be heated to 60 ℃～400 ℃ heated drying air, carry out the transient heat exchange, and be dried to medicated powder; The temperature that concentrated solution is spray dried to medicated powder is 80 ℃～400 ℃.
2, Tibetan medicine as claimed in claim 1 is urged the preparation method of decoction compositions, it is characterized in that in carrying out pretreated natural plant raw material, adding for the first time in the described step (1) water, the water yield that is added is 5～10 times of former gross weights of natural plant crude drugs, carries out heating extraction 1.5～5 hours first time to the temperature of boiling at 70 ℃.
3, Tibetan medicine as claimed in claim 1 is urged the preparation method of decoction compositions, it is characterized in that the pressure of the extracting solution behind the concentrating under reduced pressure united extraction in the described step (5) is 0.01～0.09Mpa; Extracting solution temperature after concentrating under reduced pressure merges is 40 ℃～90 ℃; Be concentrated into 0.1～0.8 times of extracting solution after the merging after the extracting solution decompression.
4, Tibetan medicine as claimed in claim 1 is urged the preparation method of decoction compositions, it is characterized in that adopting the described Tibetan medicine of claim 1 to urge the described pharmacodynamic raw materials of preparation method and the proportioning thereof of decoction compositions, carry out the step (1) of the described method of claim 1, (2), (3), in the step (3) of the described method of claim 1 afterwards, to adding water in the medicinal residues for the third time, the water yield that is added is 3～10 times that natural plant crude drugs must be measured, carried out the 4th heating extraction to the temperature of boiling 0.5～5 hour at 70 ℃, filter, obtain the 4th extracting solution and the 4th medicinal residues; Merge each time extracting solution, behind the concentrating under reduced pressure, be spray dried to the powdery medicine, spray-dired condition adopts the described condition of step (6) of the described preparation method of claim 1.
5, a kind of Tibetan medicine is urged the preparation method of decoction compositions, it is characterized in that adopting known Tibetan medicine to urge the not pharmacodynamic raw materials of ball of soup, and concrete kind is as follows:
The Radix Polygoni aubertii of the Caulis Rubi corchorifolii peeling of the peeling of Radix Inulae Radix Inulae, the heart
The Fructus Terminaliae Billericae Phlomis kawaguchii Murata of Fructus Chebulae's Fructus Phyllanthi enucleation of Fructus Hedychii Spicati enucleation
Urge the proportioning of the pharmacodynamic raw materials of soup ball to adopt following step preparation by known Tibetan medicine: added water for the first time in carrying out pretreated above-mentioned raw materials natural plant crude drugs, the water yield that is added is 5～15 times of natural plant crude drugs raw material gross weight; 70 ℃ are carried out heating extraction 1.5～6 hours first time to the temperature of boiling, the concentrating under reduced pressure extracting solution, its pressure is 0.01～0.09Mpa, the temperature of concentrating under reduced pressure is 60 ℃～90 ℃, is evaporated to 0.1～0.5 times of extracting solution of merging, when its concentrated medicament is carried out spray drying, with the water vapour is atomization gas, atomize, the pressure of atomization gas is 0.1～1.0Mpa, and exsiccant temperature is 60 ℃～500 ℃; In addition, when carrying out spray drying, also concentrated medicament can be sprayed in the hot air chamber by the centrifugal spray head, be drying medium to be heated to 60 ℃～400 ℃ hot-air, carries out the transient heat exchange, and be dried to the powdery medicine.
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| 中华人民共和国药典. 中华人民共和国卫生部药典委员会，566，617，化学工业出版社. 2000 中药药剂学. 张兆旺主编，101－103，152－154，395－396，中国中医药出版社. 2003 |
| 中华人民共和国药典. 中华人民共和国卫生部药典委员会，566，617，化学工业出版社. 2000 * |
| 中药药剂学. 张兆旺主编，101－103，152－154，395－396，中国中医药出版社. 2003 * |
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