CN100514036C - Scanned imagery device of angle type portable surface plasma resonant vibration biochemical analyzer - Google Patents
Scanned imagery device of angle type portable surface plasma resonant vibration biochemical analyzer Download PDFInfo
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- CN100514036C CN100514036C CN 200710092893 CN200710092893A CN100514036C CN 100514036 C CN100514036 C CN 100514036C CN 200710092893 CN200710092893 CN 200710092893 CN 200710092893 A CN200710092893 A CN 200710092893A CN 100514036 C CN100514036 C CN 100514036C
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Abstract
The present invention relates to an angle type portable surface plasma harmonic biochemical analyzer scanning imaging device, which comprises an optical system, an image sensor, a mechanical scanning mechanism and a drive mechanism. Wherein, a double-arm crossed pivoting mechanism is provided as the mechanical scanning mechanism. The optical system and the image sensor are arranged on double crossed arms and respectively positioned on a light input path and a light output path of an optical prism of the biochemical analyzer. A high-precision screw rod step motor serves as the drive mechanism. A drive shaft of the step motor is connected with the double-arm crossed pivoting mechanism to drive the double-arm crossed pivoting mechanism to open and close. A moving trajectory of an axial center of the pivoting mechanism realizes superposition with a central vertical line of the optical prism. The device adopts the crossed arm mechanism of equal arm length and angle to make the image sensor promptly and accurate capture variation of output lights, thus ensuring precision. A master control part of precision is an electromechanical product of relatively mature technology. The present invention has the advantages of simple structure, small size, great portability, high precision, lower cost and easy later maintenance, etc.
Description
Technical field
The present invention relates to a kind of scanister, be specifically related to a kind of the optical bio pick-up unit that is used for, the especially mechanical scanner of plasma resonant vibration body Biochemical Analyzer.
Background technology
Surface plasma resonance (SPR) Biochemical Analyzer is that a kind of sample does not need mark, do not need separation and purification, the Modern Analytical Instrument of real-time analysis bio-molecular interaction, having the not available characteristics of traditional Biochemical Analyzer, also is significant development and breakthrough to the traditional analysis instrumental function.This Biochemical Analyzer detects and is based on the highest Kretshmann type detection principle of technology maturity, and promptly incident wavelength is constant, changes incident angle, and intensity of reflected light can generate the SPR spectrum according to the change of incident angle.SPR composes demonstration: reflected light is the darkest at SPR resonance angle place, and detecting is exactly to draw different testing results according to the darkest point of SPR spectrum glazed thread.In the testing process, imageing sensor is followed emergent ray accurately, catches and carries out computational analysis, thereby obtain needed data of biochemistry detection and result.
Over past ten years, domestic rarely have the research of doing in this respect, the existing SPR device patent that comprises the electron institute Cui Dafu researcher of the Chinese Academy of Sciences: 98102366.5 and the device patent of University Of Chongqing application: 200610095365.2, what wherein the Chinese Academy of Sciences adopted is that connection rod set adds the rod-pulling type structure, what University Of Chongqing adopted is many group screw rod-turbine structures, they all exist theoretical feasible, but structure is too complicated, design accuracy is influenced greatly by processing technology, the problem of practical application difference, and cost height, defectives such as later maintenance difference have had a strong impact on popularizing of homemade SPR biochemical instruments.
And abroad, successively emerged in large numbers the product and the technology of a lot of maturations.But the price of Related product is very high, and every kind of product has distinct technical characterictic.Mainly is to be the large scale computer of representative and the portable micro computer that Texas Instrument is representative with Sweden Biacore company such as, commerce commonly used with the SPR analyser.Because the portable advantage that the difference of its immanent structure of this two class SPR analyser causes large scale computer not possess micro computer to be had, otherwise micro computer does not possess the high characteristic of the precision of large scale computer.
Summary of the invention
At above shortcomings on the prior art, the present invention discloses a kind of scanned imagery device of the angle type portable surface plasma resonant vibration biochemical analyzer based on the Kretshmann principle, adopt the arm-type structure of intersection, move by its absolute angle that waits, make imageing sensor can capture emergent ray accurately, and use screw mandrel formula stepper motor as power source, to reach whole apparatus structure compactness, miniaturization improves accuracy of detection, reliability.
Technical scheme of the present invention is as follows:
A kind of scanned imagery device of angle type portable surface plasma resonant vibration biochemical analyzer, this scanned imagery device comprise optical system, imageing sensor, mechanical scanning mechanism and driving mechanism.Wherein, described mechanical scanning mechanism adopts is that both arms intersect twisting mechanism, and optical system and imageing sensor are installed on two transposition arms, and in the incident and reflected light path of the strict respectively optical prism that is positioned at Biochemical Analyzer.The transmission shaft of driving mechanism and both arms intersect twisting mechanism and are connected, and drive both arms and intersect the folding of twisting mechanism both arms, and both arms intersect the movement locus in axle center of twisting and overlap with the vertical line at mistake optical prism center.
Described driving mechanism can high precision screw mandrel formula step motor drive, motor-belt drives or double lead motor-driven, as the power source of whole device.But adopt high precision screw mandrel formula step motor drive best, the scanning accuracy of detector is passed through electric machine controller, the repeatable position precision of zygomite rod-type stepper motor determines jointly, screw mandrel formula stepper motor has easy, compact, the good own characteristics such as mechanical property, reliability and accuracy of design, can well reach the accuracy of detection requirement of this kind equipment, whole device precision can reach 0.0001 degree, and sweep limit can reach 50 °.When design, based on mechanical characteristics of motor, further improve the segmentation of stepper motor, make mechanical scanning system regulate beam incident angle, thereby realize the purpose of minute angle scanning with high precision.In addition, the transmission shaft of high precision screw mandrel formula stepper motor is connected with the axle center of two transposition arms, makes stress point be positioned at the junction of both arms, intersect the steadily reliable of twisting mechanism kinematic to guarantee both arms.
Described both arms intersect twisting mechanism and are made of two transposition arms, guiding trestle, slideway, roller and guide rail; Described axle center by two transposition arms is connected with guiding trestle, and the end of guiding trestle is assemblied in the slideway, and slideway is fixed in the housing of device, and is also parallel with the vertical line of crossing the optical prism center; Described optical system and imageing sensor are installed on the upper end of two transposition arms, and the lower end of two transposition arms is separately installed with roller or slide block, and roller or slide block and guide rail are assembled together, and guide rail is fixed in the housing of device, and be vertical with the vertical line of crossing the optical prism center.The support of being responsible for moving on slideway guarantees that whole mechanical arm system only moves up and down along the axis, guarantees the stability of whole detection system.Because the slideway structure and the extension spring measure assurance device of device particular design can high-precisionly rotate.
Two transposition arms are engaged at twisting connection employing half tooth at place, axle center, bearing pin connects or the bearing twisting mode that hooks deeply.In order to guarantee to guarantee that under the stressed situation of single armed whole transposition arm structure can wait the angle motion, preferably adopts the engaged structure of half tooth.Connect extension spring or stage clip between further two transposition arms, so that it guarantees the reliability of half tooth interlock by the effect that adds extension spring or stage clip when rotating.
Two transposition arms are designed to wait brachium, can guarantee that the movement locus in the axle center of both arms intersection twisting overlaps with the vertical line of crossing the optical prism center, guarantee to wait the accuracy of angle.
The invention has the beneficial effects as follows, device adopts wait brachium, etc. angle formula transposition arm structure, can guarantee fully that imageing sensor accurately captures emergent ray in real time and changes; Adopt high precision electromechanical integration Scan Architecture, simple in structure, do not reducing under the prerequisite of scanning accuracy substantially, make the miniaturization of SPR Biochemical Analyzer, portability becomes possibility, has overcome the common fault of domestic and international like product; Install stressed simply, adopt multiple precision protective device, can well guarantee the validity and the accuracy of testing result; Because and the ripe relatively electronic product of precision main control part employing technology, making the simple in structure of device, it is little that accuracy of detection is influenced by processing technology; With low cost, daily being easy to safeguarded, can extensively promote this kind equipment.This device is not only applicable to SPR biochemistry detection technology, also can be applicable in the biology sensor development of relevant optical detection for the basis, such as the research of molecular array micro-nano sensor.
This device can carry out angle measurement or the light intensity test under special angle, and the test under special angle under the prerequisite of displacement light source and imageing sensor, can directly transform grating type SPR biochemistry detection system as by native system.
Description of drawings
The present invention will be further described below in conjunction with drawings and Examples.
Fig. 1 is the system architecture diagram that adopts the surface plasma resonant vibration detector of this scanned imagery device.
Fig. 2 is the structural representation of this scanned imagery device.
Fig. 3 is the side schematic view of this scanned imagery device.
Fig. 4 is that driving mechanism is motor-bel-drivenn structural representation.
Fig. 5 is that driving mechanism is the structural scheme of mechanism of double lead stepper motor.
Fig. 6 is the synoptic diagram that this two transposition arm adopts half tooth occlusion structure.
Fig. 7 is the structural representation that this two transposition arm adopts dark hook bearing twisting mode.
1. optical prisms among the figure, 2. semiconductor laser, 3. imageing sensor, 4. transposition arm, 5. extension spring, 6. both arms hinge, 7. slideway, 8. slide block (roller), 9. guide rail, 10. screw mandrel formula linear stepping motor, 11.ARM embedded signal analytic system, 12. side wall of outer shell, 13. outer shell bottom wall, 14. guiding trestles, 15. half tooth twisting structures, 16. belt, 17, stepper motor.
Embodiment
Referring to Fig. 1, the angle type portable surface plasma resonant vibration biochemical analyzer with this scanned imagery device is to be made of electric machine control system (containing segmentation drives), mechanical scanning structure, optical system, ARM embedded signal analytic system.Driven by the segmentation of control line connection motor by electric machine control system, segmentation driving connection and drive stepping motor change the angle of both arms to the transposition arm mechanism application of force of mechanical scanning structure.Imageing sensor in this scanned imagery device adopts cmos sensor or photodiode array etc. to change the light signal that captures into electric signal synchronously in real time, pass to the built-in ARM embedded signal analytic system of Biochemical Analyzer, computing obtains final detection result.
Referring to Fig. 2, optical prism 1 is installed on the inside surface of shell roof of Biochemical Analyzer.Mechanical scanning mechanism is a both arms intersection twisting mechanism, is made of two transposition arms 4, guiding trestle 14 (see figure 3)s, slideway 7, roller 8 and guide rail 9.Two transposition arms 4 are isometric, and two transposition arms 4 have adopted half tooth twisting structure 15 (as shown in Figure 4) in intersection joint portion 6.Semiconductor laser 2 and imageing sensor 3 are installed on two transposition arms, 4 upper ends, and strict respectively being positioned in the incident and reflected light path of optical prism 1.Axle center 6 by two transposition arms is connected with guiding trestle 14, and the end of guiding trestle 14 is assemblied in the slideway 7, and slideway 7 is fixed on the housing sidewall 12 of device, and parallel with the vertical line of crossing optical prism 1 center, as shown in Figure 3.The lower end of two transposition arms 4 is separately installed with slide block, and slide block and guide rail are assembled together, and guide rail is fixed on the housing bottom of device, and is vertical with the vertical line of crossing the optical prism center.
The transmission shaft of stepper motor 10 and both arms intersect twisting mechanism and are connected, and force in the intersection joint portion 6 of transposition arm 4, for the angle motion that waits of transposition arm 4 provides acting force perpendicular to the bottom surface.Transposition arm 4 is under the support of guiding trestle 14 and slideway 7, to move up and down along the vertical line of crossing optical prism 1 center, drive transposition arm 4 belows and do side-to-side movement along the track of diapire 13 through the slide block 8 of particular design, thereby making whole both arms intersect twisting mechanism is the axle center with the joint portion, making a motion that waits angle accurately (is that both arms all are θ with the angle of crossing optical prism center vertical line, make imageing sensor 3 follow the motion of emergent ray exactly, carry out the real-time conversion of photosignal, guarantee the accuracy of testing result.The extension spring 5 that connects two transposition arms 4 provides a lateral pull as the precision protective device, guarantees that the engaged structure 15 of half tooth can void not sting, and improves the measuring accuracy of whole Biochemical Analyzer.
Type of drive to both arms in this device also has plurality of optional, and such as adopting motor-belt transmissioning mode, as shown in Figure 5, electric machine controller sends control signal, triggers stepper motor 17 and drives belt 16 motions, and belt 16 drives both arms and waits the angle motion.
Or adopt the double lead motor directly to the head sheave kind of drive under the transposition arm, as shown in Figure 6, electric machine controller sends trigger pip, is positioned at two linear stepping motors 19 of device diapire, makes opposite motion synchronously, makes both arms wait the angle motion.
The both arms twisting mode of this device also can adopt other forms, such as the bearing pin connected mode or the bearing twisting mode that hooks deeply, adopts deep groove ball bearing twisting 18 as shown in Figure 7 between both arms, both arms is made under the drive of linear stepping motor waited angle to move.
The present invention is not limited to above-mentioned specific implementation method; as long as the both arms interleaved mode that adopts similar installation realizes that the angle that waits of SPR biochemistry detection system moves; no matter which kind of design both arms adopt; which kind of twisting link is the twisting mode adopt; which kind of precision safeguard measure both arms adopt; which kind of kind of drive both arms adopt move up and down along the axis, and which kind of mode the both arms lower end is adopted link to each other with the diapire guide rail and all dropped among protection scope of the present invention.
Claims (8)
1. the scanned imagery device of an angle type portable surface plasma resonant vibration biochemical analyzer, this scanister comprises optical system, imageing sensor, mechanical scanning mechanism and driving mechanism, it is characterized in that: described mechanical scanning mechanism adopts is that both arms intersect twisting mechanism, optical system and imageing sensor are installed on two transposition arms, and lay respectively in the incident and reflected light path of optical prism of Biochemical Analyzer; The transmission shaft of driving mechanism and both arms intersect twisting mechanism and are connected, and drive the folding of both arms, and both arms intersect the movement locus in axle center of twisting and overlap with the vertical line at mistake optical prism center.
2, the scanned imagery device of angle type portable surface plasma resonant vibration biochemical analyzer according to claim 1, it is characterized in that: described driving mechanism is a high precision screw mandrel formula stepper motor, and the transmission shaft of high precision screw mandrel formula stepper motor is connected with the axle center of two transposition arms.
3, the scanned imagery device of angle type portable surface plasma resonant vibration biochemical analyzer according to claim 1 is characterized in that: described driving mechanism adopts motor-belt gear.
4, the scanned imagery device of angle type portable surface plasma resonant vibration biochemical analyzer according to claim 1 is characterized in that: described driving mechanism adopts the double lead motor transmission mechanism.
5, according to the scanned imagery device of claim 1,2,3 or 4 described angle type portable surface plasma resonant vibration biochemical analyzers, it is characterized in that: described both arms intersect twisting mechanism and are made of two transposition arms, guiding trestle, slideway, roller and guide rail; Described axle center by two transposition arms is connected with guiding trestle, and the end of guiding trestle is assemblied in the slideway, and slideway is fixed in the housing of device, and is also parallel with the vertical line of crossing the optical prism center; Described optical system and imageing sensor are installed on the upper end of two transposition arms, and the lower end of two transposition arms is separately installed with roller or slide block, and roller or slide block and guide rail are assembled together, and guide rail is fixed in the housing of device, and be vertical with the vertical line of crossing the optical prism center.
6, the scanned imagery device of angle type portable surface plasma resonant vibration biochemical analyzer according to claim 5 is characterized in that: two transposition arms are designed to isometric.
7, the scanned imagery device of angle type portable surface plasma resonant vibration biochemical analyzer according to claim 5 is characterized in that: described two transposition arms adopt half tooth intermesh form, bearing pin type of attachment or the bearing twisting form that hooks deeply at axle center place.
8, the scanned imagery device of angle type portable surface plasma resonant vibration biochemical analyzer according to claim 4 is characterized in that: be connected with extension spring or stage clip between two transposition arms.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200710092893 CN100514036C (en) | 2007-10-26 | 2007-10-26 | Scanned imagery device of angle type portable surface plasma resonant vibration biochemical analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200710092893 CN100514036C (en) | 2007-10-26 | 2007-10-26 | Scanned imagery device of angle type portable surface plasma resonant vibration biochemical analyzer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101140227A CN101140227A (en) | 2008-03-12 |
| CN100514036C true CN100514036C (en) | 2009-07-15 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200710092893 Expired - Fee Related CN100514036C (en) | 2007-10-26 | 2007-10-26 | Scanned imagery device of angle type portable surface plasma resonant vibration biochemical analyzer |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110596052B (en) * | 2019-09-05 | 2021-02-19 | 北京化工大学 | Small-size multi-angle scanning surface plasma resonance biochemical analyzer |
| US11555693B2 (en) * | 2020-05-12 | 2023-01-17 | The Boeing Company | Measurement of surface profiles using unmanned aerial vehicles |
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2007
- 2007-10-26 CN CN 200710092893 patent/CN100514036C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 表面等离子体谐振(SPR)生化分析仪的研制. 崔大付，李向明，蔡浩原，李亚亭，郑自攀，陈翔.现代科学仪器，第2001-6期. 2001 |
| 表面等离子体谐振(SPR)生化分析仪的研制. 崔大付，李向明，蔡浩原，李亚亭，郑自攀，陈翔.现代科学仪器，第2001-6期. 2001 * |
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| CN101140227A (en) | 2008-03-12 |
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