CN102313729B - Portable Raman spectrometer - Google Patents
Portable Raman spectrometer Download PDFInfo
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- CN102313729B CN102313729B CN 201110217015 CN201110217015A CN102313729B CN 102313729 B CN102313729 B CN 102313729B CN 201110217015 CN201110217015 CN 201110217015 CN 201110217015 A CN201110217015 A CN 201110217015A CN 102313729 B CN102313729 B CN 102313729B
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Abstract
The invention discloses a portable Raman spectrometer. The spectrometer comprises a main system which comprises a laser, a laser probe, an analysis module and a first imaging module, wherein the laser, the laser probe, the analysis module and the first imaging module are sequentially connected; and a micro-area system which comprises an optical system of a microscope, wherein the optical system of the microscope which is connected with the laser is also connected with the analysis module, and the lower part of the optical system of the microscope is provided with a sample testboard which can bear a slide glass. In the invention, the portable Raman spectrometer allows the demand of a sample amount to be substantially reduced by means of the micro-area system and allows the routine analysis of a large sample amount to be carried out when only the main system is used for analysis. The portable Raman spectrometer which is a supplement to existing portable Raman spectrometers allows the development of the portable Raman spectrometers to be promoted.
Description
Technical field
The present invention relates to a kind of analytical instrument, relate in particular to a kind of Portable Raman spectrometer.
Background technology
Raman scattering is a kind of of light scattering phenomenon, when the light inlet photon of homogeneous beam and interaction of molecules, elastic collision and inelastic collision can occur, in the elastic collision process, photon and intermolecularly there is no an energy exchange, photon only changes direction of motion and does not change frequency, and this scattering process is called Rayleigh scattering.And in the inelastic collision process, between photon and molecule, energy exchange occurs, photon not only changes direction of motion, the part energy of photon passes to molecule simultaneously, perhaps the vibration of molecule and rotational energy pass to photon, thereby changed the frequency of photon, this scattering process is called Raman scattering.The intensity of the number of Raman line, the size of shift value and bands of a spectrum etc. are all with the vibration of material molecule with rotate relevantly, and these information have all reflected conformation and the residing environment thereof of molecule.
The different structures of matter is identified and distinguished to Raman spectroscopy from the molecular vibration spectrum of material, becomes the effective means of research material molecular structure.The analytical approach of Raman spectrum does not need sample is carried out pre-treatment, there is no the preparation process of sample yet, has avoided the generation of some errors, and simple to operate in analytic process, the advantage such as minute is short, sensitivity is high.At present, Raman spectrum has been widely used in the fields such as material, chemical industry, oil, macromolecule, biology, environmental protection, geology.
Raman spectrometer is used for collection and detection and the rectangular scattered light of incident light, and scattered light spectrum is analyzed and processed, thereby draws the molecular structure of material.But because Raman signal is very weak, require accurate complicated optical devices, be unfavorable for in-site measurement, and new working method has been opened up in the fibre-optic design that develops into optical instrument, make spectrometer can take the mode of popping one's head in and separating with apparatus subject, simplified the structure of optical system, exempted loaded down with trivial details adjustment process, improved dirigibility and the reliability used, made the Raman spectrum on-line measurement become possibility.This Raman spectrum for on-line measurement is exactly Portable Raman spectrometer.
Current two kinds of popular probes, a kind of is insertion type probe, on principle, the optical fiber that is arranged side by side by two-way consists of.During use, probe directly immerses sample, and one the tunnel is used for laser is sent to sample, and another road receives the scattered light that is produced by sample and passes it back receiving system.Another kind is the external probe, and during use, probe is placed in outside sample, and two-way optical fiber is arranged, and exciting light reaches probe by one road optical fiber from light source, converges at sample through the optical system of probe and the optical transmission window of sampling receptacle.The scattered light that comes from sample popped one's head in collect and through another road optical fiber transmission to receiving system.But above-mentioned dual mode all has problems, and analyzes exactly needed sample size larger, has so just limited the application of Raman spectrometer again, has also limited the development of Portable Raman spectrometer.
Summary of the invention
The present invention is directed to above-mentioned technical matters, designed and developed a kind of Portable Raman spectrometer.In the present invention, the microcell system integration is entered Raman spectroscopy system, and formed Portable Raman spectrometer on this basis.This Portable Raman spectrometer can be realized the micron order analysis to sample surfaces by the microcell system, greatly reduces the demand of sample size; When only using main system to analyze, can carry out again conventional large sample quantitative analysis.Therefore, the present invention replenishes a kind of of Portable Raman spectrometer, can promote the development for the Portable Raman spectrometer of on-line analysis.
Technical scheme provided by the invention is:
A kind of Portable Raman spectrometer comprises:
Main system, it includes laser instrument, laser probe, analysis module and the first image-forming module, and wherein, described laser instrument, laser probe, described analysis module and first image-forming module of being connected connect successively; And
The microcell system, it includes microscope optical system, and wherein, described microscope optical system is connected in described laser instrument, described microscope optical system also is connected in described analysis module, and the below of described microscope optical system is provided with the sample test platform that can carry microslide.
Preferably, in described Portable Raman spectrometer, the laser instrument of described main system, analysis module and the first image-forming module and described microcell system all are arranged in a casing, described laser probe is positioned at outside described casing, wherein, described casing is provided with a long and narrow hole in the position corresponding with described sample test platform, described sample test platform is by described long and narrow hole and the exterior of described casing, one side of described casing also is provided with display, and described display is connected with described the first image-forming module.
Preferably, in described Portable Raman spectrometer, also be provided with a pulling apparatus above described casing.
preferably, described Portable Raman spectrometer, also comprise: control chip, wherein, described main system is connected in described control chip, described main system is controlled by described control chip, described laser instrument sends laser to described laser probe, described analysis module gathers and analyzes Raman signal, described the first image-forming module shows the Raman spectrogram, and, described microcell system also is connected in described control chip, described microcell system is controlled by described control chip, described laser instrument sends laser to described microscope optical system, described microscope optical system is with the sample of Laser Focusing on the microslide that is positioned at described sample test platform, and Raman signal is passed to described analysis module.
Preferably, described Portable Raman spectrometer, described microcell system also comprises scanister and the second image-forming module, wherein, described scanister is connected in described control chip, sample on the microslide that is positioned at described sample test platform is scanned, described the second image-forming module is connected in described analysis module, described the second image-forming module also is connected in described control chip, described the second image-forming module is subjected to described control chip control display Raman spectrogram, and the display of described casing also is connected with described the second image-forming module.
Preferably, described Portable Raman spectrometer, also comprise: power supply chip, described power supply chip is connected in described control chip, be connected in simultaneously described main system and microcell system, listen and state power supply chip and controlled by described control chip, to described main system power supply, or described power supply chip controls by described control chip, simultaneously to described main system and microcell system power supply.
Preferably, described Portable Raman spectrometer, described microcell system also comprises slide unit, it is connected with described microscope optical system, drives described microscope optical system and moves up and down with respect to described sample test platform.
Preferably, described Portable Raman spectrometer, described microcell system also comprises slide unit, it is connected with described sample test platform, drives described sample test platform and moves up and down with respect to described microscope optical system.
Portable Raman spectrometer of the present invention enters Raman spectroscopy system with the microcell system integration, and has formed Portable Raman spectrometer on this basis.This Portable Raman spectrometer can be realized the micron order analysis to sample surfaces by the microcell system, greatly reduces the demand of sample size; When only using main system to analyze, can carry out again conventional large sample quantitative analysis.Therefore, the present invention replenishes a kind of of Portable Raman spectrometer, can promote the development for the Portable Raman spectrometer of on-line analysis.
Description of drawings
Fig. 1 is the inner structure schematic diagram of Portable Raman spectrometer of the present invention.
Fig. 2 is the external structure schematic diagram of Portable Raman spectrometer of the present invention.
Embodiment
The present invention is described in further detail below in conjunction with accompanying drawing, can implement according to this with reference to the instructions word to make those skilled in the art.
As depicted in figs. 1 and 2, the invention provides a kind of Portable Raman spectrometer, comprising: main system, it includes laser instrument 3, laser probe, analysis module 2 and the first image-forming module, wherein, described laser instrument 3, laser probe, analysis module 2 and the image-forming module of being connected connect successively; And microcell system, it includes microscope optical system 6, and wherein, described microscope optical system 6 is connected in described laser instrument 3, described microscope optical system 6 also is connected in described analysis module 2, and the below of described microscope optical system 6 is provided with the sample test platform 11 that can carry microslide.
Above-mentioned Portable Raman spectrometer is exactly integrated microcell system on the Raman spectrum main system.Above-mentioned main system has comprised laser instrument 3, laser probe, analysis module 2 and the first image-forming module (not shown), and above-mentioned four parts connect successively.Wherein, the first image-forming module is integrated in analysis module 2 inside.When using main system to detect online, the laser that laser instrument 3 generates shines in sample surfaces via laser probe 8, laser probe is collected the scattered light that comes from sample surfaces simultaneously, and be passed to analysis module 2 this Raman signal is gathered and analyzes, analysis result is shown in display 15 via the first image-forming module with the form of Raman spectrogram.
Above-mentioned analytic process is mainly for the larger situation of sample size, in sample size hour, starts the microcell system.When using the microcell system, the laser that laser instrument 3 occurs enters the light path of microscope optical system 6, the microslide that carries sample is positioned at sample test platform 7,6 pairs of Laser Focusings of microscope optical system, and will shine in sample, sample scattering light is passed to analysis module 2 via microscope optical system 6 again, thereby can gather and analyze Raman signal, and analysis result is shown in display 15 by the second image-forming module 1 with the form of Raman spectrogram.6 pairs of laser of microscope optical system have focusing function, dwindle surveyed area, have also just reduced the needs to sample size.
Generally, Portable Raman spectrometer does not possess the microcell system, and microcell system that Portable Raman spectrometer of the present invention is integrated has realized the micron order of sample surfaces is detected, and makes the application of Portable Raman spectrometer in detecting at the scene more extensive.
In one embodiment, the course of work of main system and microcell system all depends on control chip 4.The laser instrument 3 that main system comprises, analysis module 2 and the first image-forming module all are connected in control chip 4, the control of controlled chip 4, laser instrument 3 sends laser to laser probe, the scattered light that 2 pairs of analysis modules come from sample gathers and analyzes, forming similarly is to rely on the first image-forming module to realize, by the first image-forming module, the Raman spectrogram is shown in display 15.
Control the microcell system by control chip 4 and enter duty.In one embodiment, microscope optical system 6 adopts confocal microscopy.Therefore, the microcell system also contains scanister, and scanister has been realized the scanning observation to sample, together with confocal microscopy, sample is carried out nondestructively demixing scan, reaches the effect of " optical section ", to sample carry out three-dimensional pointwise, line by line, successively micro-zone analysis.The Raman signal of the confocal pinhole by microscope optical system 6, through assembling, to the entrance slit of the monochromator of analysis module 2, by monochromator splitting, imaging, be shown as the Raman spectrogram by the second image-forming module 1, form " topomap " that so-called sample material component distributes.This wherein, the switching between the control of the control of the course of work of microscope optical system 6, the course of work of scanister and the first image-forming module and the second image-forming module is all to be realized by control chip 4.
In described Portable Raman spectrometer, the laser instrument 3 of described main system, analysis module 2 and the first image-forming module and described microcell system all are arranged in a casing 13, described laser probe is positioned at described casing 13 outsides, wherein, described casing 13 is provided with a long and narrow hole 12 in the position corresponding with described sample test platform 11, described sample test platform 11 is by described long and narrow hole 12 and the exterior of described casing 13, one side of described casing 13 also is provided with display 15, and described display 15 is connected with described the first image-forming module.
In described Portable Raman spectrometer, described casing 13 tops also are provided with a pulling apparatus 14.
described Portable Raman spectrometer, also comprise: control chip 5, wherein, described main system is connected in described control chip 5, described main system is controlled by described control chip 5, described laser instrument 3 sends laser to described laser probe, 2 pairs of Raman signals of described analysis module gather and analyze, described the first image-forming module shows the Raman spectrogram, and, described microcell system also is connected in described control chip 5, described microcell system is controlled by described control chip 5, described laser instrument 3 sends laser to described microscope optical system 6, described microscope optical system 6 is with the sample of Laser Focusing on the microslide that is positioned at described sample test platform 11, and Raman signal is passed to described analysis module 2.
In described Portable Raman spectrometer, described microcell system also comprises scanister and the second image-forming module 1, wherein, described scanister is connected in described control chip 4, sample on the microslide that is positioned at described sample test platform 11 is scanned, described the second image-forming module 1 is connected in described analysis module 2, described the second image-forming module 1 also is connected in described control chip 4, described the second image-forming module 1 is subjected to described control chip 4 control display Raman spectrograms, and the display 15 of described casing 13 also is connected with described the second image-forming module 1.
Described Portable Raman spectrometer, also comprise: power supply chip 4, described power supply chip 4 is connected in described control chip 5, be connected in simultaneously described main system and microcell system, described power supply chip 4 is controlled by described control chip 5, to the power supply of described main system, or described power supply chip 4 controls by described control chip 5, simultaneously to described main system and microcell system power supply.
In described Portable Raman spectrometer, described microcell system also comprises slide unit, and it is connected with described microscope optical system 6, drives described microscope optical system 6 and moves up and down with respect to described sample test platform 11.
In described Portable Raman spectrometer, described microcell system also comprises slide unit, and it is connected with described sample test platform 11, drives described sample test platform 11 and moves up and down with respect to described microscope optical system 6.
Although embodiment of the present invention are open as above, but it is not restricted to listed utilization in instructions and embodiment, it can be applied to various suitable the field of the invention fully, for those skilled in the art, can easily realize other modification, therefore do not deviating under the universal that claim and equivalency range limit, the present invention is not limited to specific details and illustrates here and the legend of describing.
Claims (7)
1. a Portable Raman spectrometer, is characterized in that, comprising:
Main system, it includes laser instrument, laser probe, analysis module and the first image-forming module, and wherein, described laser instrument, laser probe, described analysis module and first image-forming module of being connected connect successively; And
The microcell system, it includes microscope optical system, and wherein, described microscope optical system is connected in described laser instrument, described microscope optical system also is connected in described analysis module, and the below of described microscope optical system is provided with the sample test platform that can carry microslide;
The laser instrument of described main system, analysis module and the first image-forming module and described microcell system all are arranged in a casing, described laser probe is positioned at outside described casing, wherein, described casing is provided with a long and narrow hole in the position corresponding with described sample test platform, described sample test platform is by described long and narrow hole and the exterior of described casing, one side of described casing also is provided with display, and described display is connected with described the first image-forming module.
2. Portable Raman spectrometer as claimed in claim 1, is characterized in that, also is provided with a pulling apparatus above described casing.
3. Portable Raman spectrometer as claimed in claim 1, it is characterized in that, also comprise: control chip, wherein, described main system is connected in described control chip, described main system is controlled by described control chip, described laser instrument sends laser to described laser probe, described analysis module gathers and analyzes Raman signal, described the first image-forming module shows the Raman spectrogram, and, described microcell system also is connected in described control chip, described microcell system is controlled by described control chip, described laser instrument sends laser to described microscope optical system, described microscope optical system is with the sample of Laser Focusing on the microslide that is positioned at described sample test platform, and Raman signal is passed to described analysis module.
4. Portable Raman spectrometer as claimed in claim 3, it is characterized in that, described microcell system also comprises scanister and the second image-forming module, wherein, described scanister is connected in described control chip, sample on the microslide that is positioned at described sample test platform is scanned, described the second image-forming module is connected in described analysis module, described the second image-forming module also is connected in described control chip, described the second image-forming module is subjected to described control chip control display Raman spectrogram, and the display of described casing also is connected with described the second image-forming module.
5. Portable Raman spectrometer as described in claim 3 or 4, it is characterized in that, also comprise: power supply chip, described power supply chip is connected in described control chip, be connected in simultaneously described main system and microcell system, described power supply chip is controlled by described control chip, to described main system power supply, or described power supply chip controls by described control chip, simultaneously to described main system and microcell system power supply.
6. Portable Raman spectrometer as claimed in claim 1, is characterized in that, described microcell system also comprises slide unit, and it is connected with described microscope optical system, drives described microscope optical system and moves up and down with respect to described sample test platform.
7. Portable Raman spectrometer as claimed in claim 1, is characterized in that, described microcell system also comprises slide unit, and it is connected with described sample test platform, drives described sample test platform and moves up and down with respect to described microscope optical system.
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| CN 201110217015 CN102313729B (en) | 2011-07-29 | 2011-07-29 | Portable Raman spectrometer |
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| CN 201110217015 CN102313729B (en) | 2011-07-29 | 2011-07-29 | Portable Raman spectrometer |
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| CN103424392A (en) * | 2012-05-24 | 2013-12-04 | 黄书伟 | Wavelength division SRS microscope |
| CN104865279A (en) * | 2014-02-26 | 2015-08-26 | 清华大学 | Customs supervision item rapid-inspection equipment and method |
| CN108323182A (en) * | 2018-01-02 | 2018-07-24 | 深圳达闼科技控股有限公司 | A kind of spectral measurement system |
| CN109745006B (en) * | 2019-01-31 | 2024-03-15 | 北京超维景生物科技有限公司 | Separation type adsorption device, microscope detection device and laser scanning microscope |
| CN110186904A (en) * | 2019-05-10 | 2019-08-30 | 无锡瑞生医疗科技有限公司 | Micro-Raman spectroscopy |
| CN111044500B (en) * | 2019-12-30 | 2022-12-06 | 北京华泰诺安探测技术有限公司 | Raman probe capable of adjusting annular detection area |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6545755B1 (en) * | 1999-11-26 | 2003-04-08 | Jeol Ltd. | Micro-Raman spectroscopy system for identifying foreign material on a semiconductor wafer |
| CN101514964A (en) * | 2009-03-27 | 2009-08-26 | 福州高意光学有限公司 | A material detector based on Raman spectroscopy |
| CN202182863U (en) * | 2011-07-29 | 2012-04-04 | 北京华泰诺安科技有限公司 | Portable Raman spectrometer |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6545755B1 (en) * | 1999-11-26 | 2003-04-08 | Jeol Ltd. | Micro-Raman spectroscopy system for identifying foreign material on a semiconductor wafer |
| CN101514964A (en) * | 2009-03-27 | 2009-08-26 | 福州高意光学有限公司 | A material detector based on Raman spectroscopy |
| CN202182863U (en) * | 2011-07-29 | 2012-04-04 | 北京华泰诺安科技有限公司 | Portable Raman spectrometer |
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