CN100512875C - Immune and antiallergic oral product containing IgY and potassium salt, strontium salt added composition, and its preparation method - Google Patents
Immune and antiallergic oral product containing IgY and potassium salt, strontium salt added composition, and its preparation method Download PDFInfo
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- CN100512875C CN100512875C CNB2006100540452A CN200610054045A CN100512875C CN 100512875 C CN100512875 C CN 100512875C CN B2006100540452 A CNB2006100540452 A CN B2006100540452A CN 200610054045 A CN200610054045 A CN 200610054045A CN 100512875 C CN100512875 C CN 100512875C
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Abstract
The invention relates to an immunological anti-allergic oral product containing IgY, potassium salts and strontium salts additive compositions, wherein the IgY is one or more compounds of vitellus immune globulin specific to oral pathogenic bacterium with a content of 0.1-20% by weight in the immunological anti-allergic oral product.
Description
Technical field
The present invention relates to the antianaphylactic oral cavity of a kind of immunity component, concrete is contains IgY and potassium salt, the combination of strontium salt, and this component can strengthen the immunocompetence of oral cavity to oral disease when effectively preventing and alleviating hemodia.
Technical background
Both at home and abroad normal employing of present existing antiallergic component is that one or both salts are as the desensitizing dental preparation, as a kind of strontium salt or a kind of potassium salt, or a kind of fluoride.These desensitizations are after preparations make oral-cavity article in certain proportion, and as toothpaste etc., the patient continues to use in a period of time dentin hypersensitiveness's symptom just to be eased or improves.But because in the practical application, the focus complexity of dental hypersensitivity, so these desensitizing dental preparations may poor effect, and antianaphylactic effect can not keep.Adopt IgY and potassium salt, strontium salt to make up in certain proportion among the present invention and made the desensitizing dental preparation, in the said preparation, potassium salt, strontium salt have different from desensitizing dental mechanism, simultaneously because the composite IgY that used, the antiallergic ability of said preparation is strengthened, and can continue antiallergic effect.
In dentin, there is a large amount of dentinal tubules, under normal circumstances, enamel covers canaliculi dentales, but, cause enamel impaired, gingival atrophy owing to physics, chemistry, disease, the dentin of tooth body is exposed, the canaliculi dentales permeability uprises, stimulation to external world such as hot and cold, sour, sweet and mechanical friction (brushing teeth, chew hard thing) is very responsive, thus form hemodia.
The mechanism of strontium salt desensitization is: if contain the strontium ion of trace in the dentine, can strengthen Dentinal desensitization ability.Enamel and dentin all can absorb strontium: the calcium carbonate effect in strontium and the dentine generates insoluble salt strontium carbonate SrCO
3, hydroxyl saamite Ca is produced in while and Dentinal hydroxyapatite effect
3(PO
4)
2Sr (OH)
2, on the essence surface of the dentine of wearing and tearing or exposure and be penetrated into the inner insoluble salt crystal that forms, block and cover canaliculi dentales, slow down the conduction of stimulation, thereby improved the ability of tooth antiallergic.Strontium can also the mineralising dentine character with and the ability of combine with Organic substance in the dentin (as oxygen and hemoglobin) permeability of hard tooth tissue is significantly reduced, and play antiacid desensitization.
The mechanism of potassium salt desensitization is: because potassium ion is penetrated on the dental nerve tip, the permeability of ion channel makes the ability of dental nerve conducted signal weaken on the neurocyte owing to changed, and pain perception is alleviated.
The harmful bacterium of the IgY of oral cavity pathogen in can specific inhibition oral cavity, the probiotics in the protection oral cavity makes the antibacterial ecologic structure in the oral cavity keep benign state, and has evidence IgY antibody capable to stop for a long time in the oral cavity.
The toothpaste that the safety toothpaste that one kind of Chinese invention patent CN01136486.6 prevents and treats oral disease discloses a kind of IgY of containing with and preparation method thereof.Chinese invention patent CN200510033533.0 dodecyldimethylammonium hydroxide inner salt contains application in the anti-tooth decay IgY toothpaste and a kind of toothpaste as foaming agent in making and discloses a kind of making and contain the foaming agent of toothpaste of anti-tooth decay IgY and the toothpaste of making of this foaming agent.
See with regard to present retrieval situation, yet there are no document and propose to adopt and to contain the relevant report that IgY and potassium salt, strontium salt add preparation of compositions immunity anti-allergic oral-cavity article.
Summary of the invention
Because strontium salt such as strontium chloride have the effect of sealing canaliculi dentales, mineralising dentine, thereby stop the effect of aching.And potassium salt such as potassium nitrate can weaken the activity of the dental pulp nerve conduction pain sensation.IgY has high specificity, highly sensitive, and it only suppresses pathogenic bacterium, and other probioticss of oral cavity are not had effect, makes antibacterial ecologic structure in the oral cavity to benign development.
Therefore, the optimum flora ecological environment of keeping under the effect of IgY antibody can produce synergism with the antiallergic effect of single potassium salt or single strontium salt or potassium salt, strontium salt, makes the antiallergic effect of potassium salt, strontium salt more remarkable; And,, promote and keep the antiallergic effect of strontium salt and potassium salt because the special long-acting of IgY also helps to keep good oral cavity state.
IgY of the present invention is that oral cavity pathogen comprises that dental plaque is harmful to bacterium, periodontal pathogenic bacterium such as Streptococcus mutans, actinomyces viscosus, porphyromonas gingivalis, one or more complex of special yolk immunoglobulin of actinobacillus actinomycetem comitans, sophisticated technology and product have been arranged at present, as long as promptly have relevant pathogenic antigens to exist, just can go out relevant IgY with sophisticated prepared.
The immune anti-allergic oral-cavity article that the purpose of this invention is to provide a kind of IgY of containing and potassium salt, strontium salt interpolation compositions, it can strengthen the immunocompetence of oral cavity to oral disease when effectively preventing and alleviating hemodia.Another object of the present invention provides the method that the described IgY of containing and potassium salt, strontium salt add the immune antiallergic toothpaste of compositions of producing.
The technical solution used in the present invention is such, promptly a kind ofly contains IgY and potassium salt, strontium salt adds the immune anti-allergic oral-cavity article of compositions, and it is characterized in that: described IgY is one or more complex of special yolk immunoglobulin of oral cavity pathogen; It is 0.1-20% that described IgY of containing and potassium salt, strontium salt add compositions shared percentage by weight in immune anti-allergic oral-cavity article constituent.
Described IgY of containing and potassium salt, strontium salt add compositions and comprise that IgY and potassium salt combination, IgY and the combination of strontium salt or IgY and potassium salt, strontium salt make up, and wherein the percentage by weight that accounts in the interpolation compositions of IgY is 0.1～10%.Described IgY can be the microcapsule inclusion enclave, can isolate contacting of IgY and other composition like this, can effectively keep its activity.
Technique scheme applies on the toothpaste, in the toothpaste component, comprise wetting agent, abrasivus, binding agent, surfactant, sweeting agent, essence, antiseptic and water, it is characterized in that: contain in the toothpaste component and account for the immune anti-allergic oral-cavity component that whole toothpaste component percentage by weight is 0.1～20% combination, optimal ratio is 1%～10%;
The lotion of toothpaste manufacture method of above-mentioned prescription is: adds wetting agent, adds binding agent again and stir homogenizing fast, add small powders such as sweeting agent, potassium salt and strontium salt successively, add the good IgY of dissolving again, and foaming agent and antiseptic, and evenly stir; Evacuation adds abrasivus then, stirs homogenizing, adds essence at last, stirs homogenizing, and the degassing, Paste Preparation are finished.Toothpaste is considered the most suitable oral-cavity article of technical solution of the present invention, but the present invention has more than to be limited to and be added in a kind of oral-cavity article of toothpaste, and other oral-cavity articles such as collutory, dentifrice, tooth gel, chewing gum are suitable for too.
The specific embodiment
Described IgY is one or more complex of special yolk immunoglobulin of oral cavity pathogen, Streptococcus mutans Yolk immunoglobulin for example, the actinomyces viscosus Yolk immunoglobulin, the porphyromonas gingivalis Yolk immunoglobulin, actinobacillus actinomycetem comitans Yolk immunoglobulin etc., it accounts for percentage by weight and is preferably 1～5% in IgY and potassium salt combination, in the combination of IgY and strontium salt, account for percentage by weight and be preferably 1～5%, in IgY makes up with potassium salt, strontium salt, account for percentage by weight and be preferably 1～5%.
The first-selected potassium nitrate of described potassium salt, it accounts for percentage by weight and is preferably 95～99% in IgY and potassium salt combination, account for percentage by weight and be preferably 30～70% in IgY and potassium salt, strontium salt make up.
The first-selected strontium chloride of described strontium salt, it accounts for percentage by weight and is preferably 95～99% in IgY and potassium salt combination, and strontium salt accounts for percentage by weight and is preferably 30～70% in IgY and potassium salt, strontium salt make up.
Described immune antiallergic component applies on the toothpaste, and it accounts for percentage by weight and is preferably 0.5%～10% in whole paste components.
Described immune antiallergic component applies on the toothpaste, and wetting agent can use single or its mixture such as glycerol, sorbitol, propylene glycol, and formula proportion can be 10%～70%, and preferred 20%～40%;
Described immune antiallergic component applies on the toothpaste, and binding agent can use single or its mixture such as sodium hydroxyethyl cellulose, carboxymethyl cellulose, carrageenan, yellow first glue, and formula proportion can be 0.1%～10%, and preferred 0.5%～2%;
Described immune antiallergic component applies on the toothpaste, and abrasivus can use calcium carbonate, hydrated SiO 2, calcium hydrogen phosphate, aluminium hydroxide etc., and formula proportion can be 10%～60%, and preferred 20%～50%.
Described immune antiallergic component applies on the toothpaste; surfactant comprises: single or its mixture such as anion, cation, both sexes and non-ionic surface active agent; for example sodium lauryl sulfate, N-acyl group sodium sarcosinate, hydramine, poloxamer; preferred nonionic surfactants such as poloxamer; amount ranges is can be 0.1%～10%, preferred 0.1%～3%.
Described immune antiallergic component applies on the toothpaste, and sweeting agent comprises: saccharin sodium, stevioside etc.Amount ranges 0.1%～2%, preferred 0.1%～0.5%.
Described immune antiallergic component applies on the toothpaste, and antiseptic comprises: parabenzoic acid ester and sodium benzoate etc.Amount ranges 0.1%～2%, preferred 0.1%～1%.
Described immune antiallergic component applies on the toothpaste, and essence can use Herba Menthae, Oleum Menthae Rotundifoliae, Mentha piperita, anethole etc.Amount ranges 0.1%～5%, preferred 0.1%～1.5%.
Hydromining pure water, consumption are 10%～50%, preferred 15%～30%.
For verifying the antiallergic effect of IgY of the present invention and potassium salt, strontium salt pref, it is added in this toothpaste implements, but do not limit the present invention.
Table 1 Example formulations table
Production technology is: add earlier wetting agent in main frame, as sorbitol, glycerol, add adhesive C MC again and stir homogenizing fast, add small powders such as saccharin sodium, potassium nitrate and strontium chloride successively, add the good IgY of dissolving again, foaming agent and sodium benzoate, and evenly stir; Evacuation adds abrasive material silicon dioxide then, stirs homogenizing, adds essence at last, stirs homogenizing, outgases, makes mastic.IgY described in the test is the Streptococcus mutans Yolk immunoglobulin, actinomyces viscosus Yolk immunoglobulin porphyromonas gingivalis Yolk immunoglobulin, actinobacillus actinomycetem comitans Yolk immunoglobulin or theirs is compound.
Four groups of toothpaste shown in the his-and-hers watches 1 carry out the antiallergic clinical trial, and 120 people that suffer from sensitivity of tooth are divided into equal four groups at random.The toothpaste that they (brush teeth twice) on the basis of daily habits and organize with I, II, III, IV respectively every day continues three months.The results are shown in Table 2.
Table 2 result of the test
Conclusion: from table 2; we as can be seen; the effect of II group and I organize blank sample contrast does not have significant difference; illustrate and use IgY not have antiallergic effect separately; III group and IV group all have antiallergic effect; but IV group effect significantly is better than III group effect; this illustrates potassium salt; strontium salt has antianaphylactic effect; but after IgY is composite, significantly improved potassium salt really; the effect of the anti-hemodia of strontium salt; reduce and prevented patient's responsive phenomenon; clinical trial is also observed and has been used the potassium salt that adds IgY simultaneously; behind the strontium salt toothpaste, the inner pernicious bacteria in patient's oral cavity is suppressed, and probiotics is protected; the oral microorganism environment is benign development; under this environment, help to keep and prolong antianaphylactic curative effect, and help to resist the generation of other oral disease.
Claims (8)
1, a kind ofly contain IgY and potassium salt, strontium salt adds the immune anti-allergic oral-cavity article of compositions, it is characterized in that: described IgY is one or more complex of the special yolk immunoglobulin of oral cavity pathogen; It is 0.1-20% that described IgY of containing and potassium salt, strontium salt add compositions shared percentage by weight in immune anti-allergic oral-cavity article constituent.
2, as claimed in claim 1ly contain the immune antiallergic that IgY and potassium salt, strontium salt add compositions
Oral-cavity article is characterized in that: described IgY of containing and potassium salt, strontium salt add compositions and comprise that IgY and potassium salt combination, IgY and the combination of strontium salt or IgY and potassium salt, strontium salt make up, and wherein the percentage by weight that accounts in the interpolation compositions of IgY is 0.1-10%.
3, as claimed in claim 1 or 2ly contain IgY and potassium salt, strontium salt adds the immune anti-allergic oral-cavity article of compositions, it is characterized in that: described IgY is wrapped up by microcapsule.
4, as claimed in claim 1 or 2ly contain IgY and potassium salt, strontium salt adds the immune anti-allergic oral-cavity article of compositions, it is characterized in that: the special yolk immunoglobulin of described oral cavity pathogen comprises change people streptococcus Yolk immunoglobulin, the actinomyces viscosus Yolk immunoglobulin, the porphyromonas gingivalis Yolk immunoglobulin, the actinobacillus actinomycetem comitans Yolk immunoglobulin.
5, as claimed in claim 1 or 2ly contain IgY and potassium salt, strontium salt adds the immune anti-allergic oral-cavity article of compositions, it is characterized in that: described potassium salt is potassium nitrate.
6, as claimed in claim 1 or 2ly contain IgY and potassium salt, strontium salt adds the immune anti-allergic oral-cavity article of compositions, it is characterized in that: described strontium salt is strontium chloride.
7, a kind ofly contain IgY and potassium salt, strontium salt adds the immune antiallergic toothpaste of compositions, in toothpaste component, comprise wetting agent, abrasivus, binding agent, surfactant, sweeting agent, essence, antiseptic and water, it is characterized in that: it is 0.1-20% that IgY and potassium salt in the toothpaste component, strontium salt add the percentage by weight that compositions accounts for whole toothpaste component.
8, a kind of preparation is as the method for immune antiallergic toothpaste as described in the claim 7, it is characterized in that, at first add wetting agent, add binding agent again and stir homogenizing fast, add sweeting agent, potassium salt and strontium salt successively, add the good IgY of dissolving again, foaming agent and antiseptic, and evenly stir: evacuation adds abrasivus then, stirs homogenizing, adds essence at last, stir homogenizing, the degassing, Paste Preparation are finished.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006100540452A CN100512875C (en) | 2006-01-20 | 2006-01-20 | Immune and antiallergic oral product containing IgY and potassium salt, strontium salt added composition, and its preparation method |
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|---|---|---|---|
| CNB2006100540452A CN100512875C (en) | 2006-01-20 | 2006-01-20 | Immune and antiallergic oral product containing IgY and potassium salt, strontium salt added composition, and its preparation method |
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| CN1803190A CN1803190A (en) | 2006-07-19 |
| CN100512875C true CN100512875C (en) | 2009-07-15 |
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| CN102641216A (en) * | 2012-04-20 | 2012-08-22 | 湖北楚冠生物药业有限公司 | Tooth-strengthening and odontogeny-preventing element and preparation method thereof |
| CN108042387A (en) * | 2017-12-11 | 2018-05-18 | 陕西瑞凯生物科技有限公司 | A kind of antibacterial mouthwash of bioprotein and preparation method thereof |
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