CN108042387A - A kind of antibacterial mouthwash of bioprotein and preparation method thereof - Google Patents
A kind of antibacterial mouthwash of bioprotein and preparation method thereof Download PDFInfo
- Publication number
- CN108042387A CN108042387A CN201711304065.5A CN201711304065A CN108042387A CN 108042387 A CN108042387 A CN 108042387A CN 201711304065 A CN201711304065 A CN 201711304065A CN 108042387 A CN108042387 A CN 108042387A
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- CN
- China
- Prior art keywords
- bioprotein
- yolk
- antibacterial mouthwash
- mouthwash
- antibacterial
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- 239000002324 mouth wash Substances 0.000 title claims abstract description 52
- 229940051866 mouthwash Drugs 0.000 title claims abstract description 50
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims description 18
- 210000002969 egg yolk Anatomy 0.000 claims abstract description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000004094 surface-active agent Substances 0.000 claims abstract description 17
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 16
- 239000003765 sweetening agent Substances 0.000 claims abstract description 16
- 241000193987 Streptococcus sobrinus Species 0.000 claims abstract description 14
- 241000202934 Mycoplasma pneumoniae Species 0.000 claims abstract description 13
- 241000712461 unidentified influenza virus Species 0.000 claims abstract description 13
- HKIKAXXIWJHWLY-ZIIYPAMZSA-N Aloesin Chemical compound C=12OC(CC(=O)C)=CC(=O)C2=C(C)C=C(O)C=1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HKIKAXXIWJHWLY-ZIIYPAMZSA-N 0.000 claims abstract description 12
- HKIKAXXIWJHWLY-QEVGBQTESA-N Aloesin Natural products O=C(CC=1Oc2c([C@H]3[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O3)c(O)cc(C)c2C(=O)C=1)C HKIKAXXIWJHWLY-QEVGBQTESA-N 0.000 claims abstract description 12
- 239000004088 foaming agent Substances 0.000 claims abstract description 11
- 150000001875 compounds Chemical class 0.000 claims abstract description 10
- 239000008367 deionised water Substances 0.000 claims abstract description 10
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 10
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims abstract description 8
- 244000052616 bacterial pathogen Species 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims description 25
- 241000272534 Struthio camelus Species 0.000 claims description 19
- 235000013601 eggs Nutrition 0.000 claims description 16
- 238000007865 diluting Methods 0.000 claims description 14
- 239000000427 antigen Substances 0.000 claims description 12
- 102000036639 antigens Human genes 0.000 claims description 12
- 108091007433 antigens Proteins 0.000 claims description 12
- 239000000047 product Substances 0.000 claims description 11
- 241000894006 Bacteria Species 0.000 claims description 10
- 235000019202 steviosides Nutrition 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 9
- 238000012360 testing method Methods 0.000 claims description 9
- 238000000605 extraction Methods 0.000 claims description 8
- YWPVROCHNBYFTP-UHFFFAOYSA-N Rubusoside Natural products C1CC2C3(C)CCCC(C)(C(=O)OC4C(C(O)C(O)C(CO)O4)O)C3CCC2(C2)CC(=C)C21OC1OC(CO)C(O)C(O)C1O YWPVROCHNBYFTP-UHFFFAOYSA-N 0.000 claims description 6
- YGCFIWIQZPHFLU-UHFFFAOYSA-N acesulfame Chemical compound CC1=CC(=O)NS(=O)(=O)O1 YGCFIWIQZPHFLU-UHFFFAOYSA-N 0.000 claims description 6
- 229960005164 acesulfame Drugs 0.000 claims description 6
- 238000010790 dilution Methods 0.000 claims description 6
- 239000012895 dilution Substances 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- 238000001556 precipitation Methods 0.000 claims description 6
- YWPVROCHNBYFTP-OSHKXICASA-N rubusoside Chemical compound O([C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O YWPVROCHNBYFTP-OSHKXICASA-N 0.000 claims description 6
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical class OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims description 5
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 5
- 108010011485 Aspartame Proteins 0.000 claims description 5
- 239000004383 Steviol glycoside Substances 0.000 claims description 5
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 5
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 5
- 239000000605 aspartame Substances 0.000 claims description 5
- 235000010357 aspartame Nutrition 0.000 claims description 5
- 229960003438 aspartame Drugs 0.000 claims description 5
- 229940099371 diacetylated monoglycerides Drugs 0.000 claims description 5
- 239000012153 distilled water Substances 0.000 claims description 5
- 238000000265 homogenisation Methods 0.000 claims description 5
- 244000005700 microbiome Species 0.000 claims description 5
- 244000052769 pathogen Species 0.000 claims description 5
- 235000010413 sodium alginate Nutrition 0.000 claims description 5
- 239000000661 sodium alginate Substances 0.000 claims description 5
- 229940005550 sodium alginate Drugs 0.000 claims description 5
- -1 sorbitan ester Chemical class 0.000 claims description 5
- 235000019411 steviol glycoside Nutrition 0.000 claims description 5
- 229930182488 steviol glycoside Natural products 0.000 claims description 5
- 150000008144 steviol glycosides Chemical class 0.000 claims description 5
- 229940013618 stevioside Drugs 0.000 claims description 5
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 239000006228 supernatant Substances 0.000 claims description 4
- 238000001514 detection method Methods 0.000 claims description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 2
- DCXXMTOCNZCJGO-UHFFFAOYSA-N Glycerol trioctadecanoate Natural products CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 2
- 102000002322 Egg Proteins Human genes 0.000 claims 1
- 108010000912 Egg Proteins Proteins 0.000 claims 1
- 241000544066 Stevia Species 0.000 claims 1
- 244000228451 Stevia rebaudiana Species 0.000 claims 1
- 235000006092 Stevia rebaudiana Nutrition 0.000 claims 1
- 229930182478 glucoside Natural products 0.000 claims 1
- 150000008131 glucosides Chemical class 0.000 claims 1
- 229930182470 glycoside Natural products 0.000 claims 1
- 150000002338 glycosides Chemical class 0.000 claims 1
- 210000004681 ovum Anatomy 0.000 claims 1
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 8
- 208000030194 mouth disease Diseases 0.000 abstract description 7
- 208000002925 dental caries Diseases 0.000 abstract description 5
- 230000000845 anti-microbial effect Effects 0.000 abstract description 3
- 208000023504 respiratory system disease Diseases 0.000 abstract description 3
- 230000000694 effects Effects 0.000 description 5
- 208000030303 breathing problems Diseases 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 description 3
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 description 3
- 235000021360 Myristic acid Nutrition 0.000 description 3
- QOSMNYMQXIVWKY-UHFFFAOYSA-N Propyl levulinate Chemical compound CCCOC(=O)CCC(C)=O QOSMNYMQXIVWKY-UHFFFAOYSA-N 0.000 description 3
- QNJOGIUEKUPUNW-UHFFFAOYSA-N [Na].C(CCCCCCCCCCCCCCCCC)C(C(=O)O)(O)C Chemical compound [Na].C(CCCCCCCCCCCCCCCCC)C(C(=O)O)(O)C QNJOGIUEKUPUNW-UHFFFAOYSA-N 0.000 description 3
- 208000025157 Oral disease Diseases 0.000 description 2
- 230000002155 anti-virotic effect Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 210000004489 deciduous teeth Anatomy 0.000 description 2
- 230000006806 disease prevention Effects 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- AXISYYRBXTVTFY-UHFFFAOYSA-N Isopropyl tetradecanoate Chemical compound CCCCCCCCCCCCCC(=O)OC(C)C AXISYYRBXTVTFY-UHFFFAOYSA-N 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 230000006472 autoimmune response Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 208000034158 bleeding Diseases 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 229940112822 chewing gum Drugs 0.000 description 1
- 235000015218 chewing gum Nutrition 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 206010022000 influenza Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007937 lozenge Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 208000004371 toothache Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/02—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from eggs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1018—Orthomyxoviridae, e.g. influenza virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1253—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Mycoplasmatales, e.g. Pleuropneumonia-like organisms [PPLO]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
- C12Q1/06—Quantitative determination
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/11—Immunoglobulins specific features characterized by their source of isolation or production isolated from eggs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/23—Immunoglobulins specific features characterized by taxonomic origin from birds
Abstract
The invention discloses a kind of antibacterial mouthwashes of bioprotein, by weight percentage, mainly consist of the following compositions：Yolk bioprotein 0.03 1%, isopropyl myristate 0.01 0.5%, Aloesin 0.08 0.1%, surfactant 0.02 0.1%, foaming agent 0.02 0.3%, sweetener 0.2 0.5%, surplus are deionized water；The yolk bioprotein be to resistance to deformation hammer mattress, streptococcus sobrinus, influenza virus, mycoplasma pneumoniae, five kinds of germs of pneumobacillus compound antibody.The antibacterial mouthwash of bioprotein of the present invention has the characteristics that safe, good antimicrobial effect, can effectively prevent the mouth diseases such as Primary Caries disease and upper respiratory disease.
Description
Technical field
The present invention relates to mouthwash technical fields, are specifically related to a kind of antibacterial mouthwash of bioprotein and its preparation side
Method.
Background technology
With the increasingly raising of people's living standard, people increasingly pay attention to the health of itself.Wherein oral health
It is critically important one, it is oral cavity frequently-occurring disease that oral problem, which generally comprises the diseases such as toothache, gingivitis, periodontitis, bleeding gums,
Disease.There are many oral cleaning class products in the market, the dental products for having preferable effect to related oral disease are few, mainly
Lack the effect of corresponding material base.Medicament such as lozenge, chewing-gum, the diaphragm of oral disease prevention and control are presently used in teeth space
It is difficult to penetrate, it is difficult to play due therapeutic effect, and the preparation used is made mostly of coarse extract, effective component content
It is low and unstable, it is difficult to achieve the effect that set.
Oral care product species in the market is various, but fails to meet the requirements in safe efficient and disease prevention,
Contain the preservative for being unfavorable for health or the ingredient of antibiotic etc in many products.In addition, there is presently no will gargle
This oral cleaning health product of water is for the prevention to some common breathing problems.Therefore, this invention address that developing
Locate a kind of can effectively prevent mouth disease but also effectively prevent the mouthwash of common breathing problem.
The content of the invention
Present invention solves the technical problem that being that existing oral care product security is not high enough, effect is not good enough, and not
Some common breathing problems can be prevented, and then a kind of antibacterial mouthwash of bioprotein and preparation method thereof is provided.
The technical scheme is that：
A kind of antibacterial mouthwash of bioprotein, by weight percentage, mainly consists of the following compositions：Yolk bioprotein
0.03-1%, isopropyl myristate 0.01-0.5%, Aloesin 0.08-0.1%, surfactant 0.02-0.1%, hair
Infusion 0.02-0.3%, sweetener 0.2-0.5%, surplus are deionized water；The yolk bioprotein is to resistance to deformation hammer
Mattress, streptococcus sobrinus, influenza virus, mycoplasma pneumoniae, the compound antibody of five kinds of germs of pneumobacillus.It can also be as needed
Other mouth diseases or breathing problem of prevention are increased and decreased adjustment to contained antibody type.
Further, the preparation method of the yolk bioprotein is：
S1：Deformation hammer mattress, streptococcus sobrinus, influenza virus, mycoplasma pneumoniae, pneumobacillus are turned out in selection；
S2：It is mixed with the pathogenic species of S1 cultures by proper proportion, generally equal proportion；Then 1 is pressed:1 ratio addition etc.
The freund adjuvant of amount；It is homogenized at a high speed with 10000-30000rpm with high speed homogenizer again and is prepared into complex antigen；
S3：Ostrich of laying eggs is injected with the complex antigen, searches the immune egg that ostrich is given birth to, extraction is made
The yolk bioprotein.
Further, the concrete operation method that the yolk bioprotein is made in the S3 extractions is：Use yolk
Sieve takes out the yolk of immune egg, beats uniform；By 1:The volume ratio of 6-7 adds in sterile purified water dilution mixing；Adjust pH value extremely
5.2；Concentration is added in as 3% sodium alginate to final concentration of 2.2 ‰, stirring is until there is turbidity and precipitation；It is 1.5% to add in concentration
CaCl2Liquid is stirred evenly to final concentration of 1.2 ‰；When standing 15-20 is small under the conditions of being placed in 3-5 DEG C, then siphon is collected
Clearly, the yolk bioprotein is obtained.
Further, the sweetener is selected from：Steviol glycoside, Rubusoside, aspartame, acesulfame or stevioside.
Further, the surfactant is selected from：Monoglyceride class, acetylated monoglycerides, Sorbitan
Any one in alcohol ester, stearin-based lactate.
A kind of preparation method of the antibacterial mouthwash of bioprotein is：It is matched by described by ostrich Yolk antibody, myristic acid
Isopropyl ester, Aloesin, surfactant, foaming agent, sweetener, deionized water mixing, are placed in homogenizer and carry out at homogeneous
Reason, temperature are 5-40 DEG C, time 3-10min.
A kind of detection method of the content of microorganisms of the antibacterial mouthwash of bioprotein is：
1) the antibacterial mouthwash 5ml of the bioprotein is taken, as sample to be tested, according to 1:10 multiple proportions is diluted, and is obtained
To sample diluting liquid；
2) above-mentioned sample diluting liquid is fitted into triangular flask or test tube, is placed in water bath with thermostatic control and carries out constant temperature processing 10~20
Minute, temperature is 25-35 DEG C；Meanwhile it is placed in same water bath and carries out at constant temperature as reference standard liquid using distilled water
Reason 10~20 minutes；
3) sample diluting liquid handled through constant temperature is taken out, conventionally draws and carries out Tu wares, be then placed in incubator
In cultivated；
4) visible bacterium colony is grown within 2~3 days on rear plate, takes out and carries out conventional bacterium colony counting and calculate, obtain the sample
Total plate count in product, you can represent the effective microbe content of the antibacterial mouthwash of the bioprotein.
The Detection of Stability standard of the antibacterial mouthwash of bioprotein, which is characterized in that including herein below：
Liquid：It is homogeneous, no precipitation, foreign；
Fragrance：Meet respective smell, free from extraneous odour；
Color and luster：Clear；
PH value：5.8-9.0；
Total plate count：≦100(CFU/g)；
Yeast and mold sum：≦10(CFU/g)；
Excrement colibacillus group：It must not detect；
Staphylococcus aureus：It must not detect；
Pseudomonas aeruginosa：It must not detect；
Yolk bioprotein:≧0.3g/kg
Fluorescer：It must not detect；
Lead：It must not detect；
Mercury：It must not detect；
Arsenic：It must not detect.
It is certified products to meet more than standard.
The beneficial effects of the invention are as follows：The present invention is exempted from using oral cavity pathogenic antigens with several frequently seen respiratory tract pathogenic antigens
To ostrich of laying eggs, the antibody that ostrich autoimmune response generates can be transferred in ostrich yolk epidemic disease, be made by Yolk antibody (IgY)
Standby technology is made yolk extraction to resistance to deformation hammer mattress, streptococcus sobrinus, influenza virus, mycoplasma pneumoniae, pneumonia
The compound antibody (Igy) of bacillus, the antibacterial mouthwash of bioprotein by the compound antibody of preparation in mouthwash, being prepared
There is safe, good antimicrobial effect, can effectively prevent the mouth diseases such as Primary Caries disease and upper respiratory disease.
Specific embodiment
Embodiment 1
A kind of antibacterial mouthwash of bioprotein, by weight percentage, mainly consists of the following compositions：Yolk bioprotein
0.03%th, isopropyl myristate 0.01%, Aloesin 0.08%, surfactant 0.02%, foaming agent 0.02%, sweet taste
Agent 0.2%, surplus are deionized water；The yolk bioprotein be to resistance to deformation hammer mattress, streptococcus sobrinus, influenza virus,
Mycoplasma pneumoniae, the compound antibody of five kinds of germs of pneumobacillus.
Wherein, the preparation method of yolk bioprotein is：
S1：Deformation hammer mattress, streptococcus sobrinus, influenza virus, mycoplasma pneumoniae, pneumobacillus are turned out in selection；
S2：It is mixed with the pathogenic species of S1 cultures by equal proportion；Then 1 is pressed:1 ratio adds in the freund adjuvant of equivalent；Again
It is homogenized at a high speed with 10000rpm with high speed homogenizer and is prepared into complex antigen；
S3：Ostrich of laying eggs is injected with the complex antigen, searches the immune egg that ostrich is given birth to, extraction is made
The yolk bioprotein.Concrete operation method is：The yolk of immune egg is taken out with yolk sieve, is beaten uniform；By 1:6 volume
Than adding in sterile purified water dilution mixing；PH value is adjusted to 5.2；Add in concentration for 3% sodium alginate to final concentration of 2.2 ‰, stir
It mixes until there is turbidity and precipitation；Add in the CaCl that concentration is 1.5%2Liquid is stirred evenly to final concentration of 1.2 ‰；It is placed in 3 DEG C of items
When standing 15 is small under part, supernatant is collected in then siphon, obtains the yolk bioprotein.
Sweetener is steviol glycoside, Rubusoside, aspartame, acesulfame or stevioside.
Surfactant is monoglyceride class, acetylated monoglycerides, sorbitan ester, stearyl lactic acid
Sodium.
The preparation method of the antibacterial mouthwash of the bioprotein is：It is by the proportioning that ostrich Yolk antibody, myristic acid is different
Propyl ester, Aloesin, surfactant, foaming agent, sweetener, deionized water mixing, are placed in homogenizer and carry out homogenization,
Temperature is 5 DEG C, time 3min.
The content of microorganisms of the antibacterial mouthwash of the bioprotein is detected：
1) the antibacterial mouthwash 5ml of the bioprotein is taken, as sample to be tested, according to 1:10 multiple proportions is diluted, and is obtained
To sample diluting liquid；
2) above-mentioned sample diluting liquid is fitted into triangular flask or test tube, is placed in water bath with thermostatic control and carries out 10 points of constant temperature processing
Clock, temperature are 25 DEG C；Meanwhile it is placed in same water bath as reference standard liquid using distilled water and carries out constant temperature processing 10
Minute；
3) sample diluting liquid handled through constant temperature is taken out, conventionally draws and carries out Tu wares, be then placed in incubator
In cultivated；
4) visible bacterium colony is grown within 2 days on rear plate, takes out and carries out conventional bacterium colony counting and calculate, obtain in the sample
Total plate count, you can represent the effective microbe content of the antibacterial mouthwash of the bioprotein.
After testing, it is found that the antibacterial mouthwash of the bioprotein complies with standard.
Embodiment 2
A kind of antibacterial mouthwash of bioprotein, by weight percentage, mainly consists of the following compositions：Yolk bioprotein
0.515%th, isopropyl myristate 0.255%, Aloesin 0.09%, surfactant 0.06%, foaming agent 0.16%, sweet tea
Taste agent 0.35%, surplus are deionized water；The yolk bioprotein is to resistance to deformation hammer mattress, streptococcus sobrinus, influenza disease
Poison, mycoplasma pneumoniae, the compound antibody of five kinds of germs of pneumobacillus.
Wherein, the preparation method of yolk bioprotein is：
S1：Deformation hammer mattress, streptococcus sobrinus, influenza virus, mycoplasma pneumoniae, pneumobacillus are turned out in selection；
S2：It is mixed with the pathogenic species of S1 cultures by equal proportion；Then 1 is pressed:1 ratio adds in the freund adjuvant of equivalent；Again
It is homogenized at a high speed with 20000rpm with high speed homogenizer and is prepared into complex antigen；
S3：Ostrich of laying eggs is injected with the complex antigen, searches the immune egg that ostrich is given birth to, extraction is made
The yolk bioprotein.Concrete operation method is：The yolk of immune egg is taken out with yolk sieve, is beaten uniform；By 1:6.5 body
Product is than adding in sterile purified water dilution mixing；PH value is adjusted to 5.2；Concentration is added in as 3% sodium alginate to final concentration of 2.2 ‰,
Stirring is until there is turbidity and precipitation；Add in the CaCl that concentration is 1.5%2Liquid is stirred evenly to final concentration of 1.2 ‰；It is placed in 4 DEG C
Under the conditions of stand 18 it is small when, supernatant is collected in then siphon, obtains the yolk bioprotein.
Sweetener is steviol glycoside, Rubusoside, aspartame, acesulfame or stevioside.
Surfactant is monoglyceride class, acetylated monoglycerides, sorbitan ester, stearyl lactic acid
Sodium.
The preparation method of the antibacterial mouthwash of the bioprotein is：It is by the proportioning that ostrich Yolk antibody, myristic acid is different
Propyl ester, Aloesin, surfactant, foaming agent, sweetener, deionized water mixing, are placed in homogenizer and carry out homogenization,
Temperature is 22.5 DEG C, time 6min.
The content of microorganisms of the antibacterial mouthwash of the bioprotein is detected：
1) the antibacterial mouthwash 5ml of the bioprotein is taken, as sample to be tested, according to 1:10 multiple proportions is diluted, and is obtained
To sample diluting liquid；
2) above-mentioned sample diluting liquid is fitted into triangular flask or test tube, is placed in water bath with thermostatic control and carries out 15 points of constant temperature processing
Clock, temperature are 30 DEG C；Meanwhile it is placed in same water bath as reference standard liquid using distilled water and carries out constant temperature processing 15
Minute；
3) sample diluting liquid handled through constant temperature is taken out, conventionally draws and carries out Tu wares, be then placed in incubator
In cultivated；
4) visible bacterium colony is grown within 2 days on rear plate, takes out and carries out conventional bacterium colony counting and calculate, obtain in the sample
Total plate count, you can represent the effective microbe content of the antibacterial mouthwash of the bioprotein.
After testing, it is found that the antibacterial mouthwash of the bioprotein complies with standard.
Embodiment 3
A kind of antibacterial mouthwash of bioprotein, by weight percentage, mainly consists of the following compositions：Yolk bioprotein
1%th, isopropyl myristate 0.5%, Aloesin 0.1%, surfactant 0.1%, foaming agent 0.3%, sweetener
0.5%th, surplus is deionized water；The yolk bioprotein is to resistance to deformation hammer mattress, streptococcus sobrinus, influenza virus, lung
Scorching type mycoplasma, the compound antibody of five kinds of germs of pneumobacillus.
Wherein, the preparation method of yolk bioprotein is：
S1：Deformation hammer mattress, streptococcus sobrinus, influenza virus, mycoplasma pneumoniae, pneumobacillus are turned out in selection；
S2：It is mixed with the pathogenic species of S1 cultures by equal proportion；Then 1 is pressed:1 ratio adds in the freund adjuvant of equivalent；Again
It is homogenized at a high speed with 30000rpm with high speed homogenizer and is prepared into complex antigen；
S3：Ostrich of laying eggs is injected with the complex antigen, searches the immune egg that ostrich is given birth to, extraction is made
The yolk bioprotein.Concrete operation method is：The yolk of immune egg is taken out with yolk sieve, is beaten uniform；By 1:7 volume
Than adding in sterile purified water dilution mixing；PH value is adjusted to 5.2；Add in concentration for 3% sodium alginate to final concentration of 2.2 ‰, stir
It mixes until there is turbidity and precipitation；Add in the CaCl that concentration is 1.5%2Liquid is stirred evenly to final concentration of 1.2 ‰；It is placed in 5 DEG C of items
When standing 20 is small under part, supernatant is collected in then siphon, obtains the yolk bioprotein.
Sweetener is steviol glycoside, Rubusoside, aspartame, acesulfame or stevioside.
Surfactant is monoglyceride class, acetylated monoglycerides, sorbitan ester, stearyl lactic acid
Sodium.
The preparation method of the antibacterial mouthwash of the bioprotein is：It is by the proportioning that ostrich Yolk antibody, myristic acid is different
Propyl ester, Aloesin, surfactant, foaming agent, sweetener, deionized water mixing, are placed in homogenizer and carry out homogenization,
Temperature is 40 DEG C, time 10min.
The content of microorganisms of the antibacterial mouthwash of the bioprotein is detected：
1) the antibacterial mouthwash 5ml of the bioprotein is taken, as sample to be tested, according to 1:10 multiple proportions is diluted, and is obtained
To sample diluting liquid；
2) above-mentioned sample diluting liquid is fitted into triangular flask or test tube, is placed in water bath with thermostatic control and carries out 20 points of constant temperature processing
Clock, temperature are 35 DEG C；Meanwhile it is placed in same water bath as reference standard liquid using distilled water and carries out constant temperature processing 20
Minute；
3) sample diluting liquid handled through constant temperature is taken out, conventionally draws and carries out Tu wares, be then placed in incubator
In cultivated；
4) visible bacterium colony is grown within 3 days on rear plate, takes out and carries out conventional bacterium colony counting and calculate, obtain in the sample
Total plate count, you can represent the effective microbe content of the antibacterial mouthwash of the bioprotein.
After testing, it is found that the antibacterial mouthwash of the bioprotein complies with standard.
Using data：
With mouthwash and certain brand (Li Shidelin) mouthwash available on the market prepared by the embodiment of the present invention 1,2,3 into
Row contrast test chooses 300 children volunteers, is divided into 5 groups at random, every group of 60 people, without significant difference between each group, wherein
1st, 2,3 groups of mouthwashes prepared respectively using the embodiment of the present invention 1,2,3, the 4th group is gargled as a control group using Li Shidelin boards
Saliva, the 5th group is used as blank group, and using clear water, all hope persons are daily three to gargle after the meal, are tied after 3 months
Fruit counts, and statistical indicator includes resistance to deformation hammer mattress, streptococcus sobrinus, influenza virus, mycoplasma pneumoniae, pneumobacillus and youngster
The incidence of virgin caries in primary teeth, is specifically shown in the following table 1.
Resistance to deformation hammer mattress, streptococcus sobrinus, influenza virus, mycoplasma pneumoniae, the compound antibody of pneumobacillus
(Igy), the antibacterial mouthwash of bioprotein by the compound antibody of preparation in mouthwash, being prepared have it is safe,
The characteristics of good antimicrobial effect, can effectively prevent the mouth diseases such as Primary Caries disease and upper respiratory disease.
Table 1：The anti-bacteria and anti-virus situation statistics of each group mouthwash
It turns out that mouthwash anti-bacteria and anti-virus effect prepared by the present invention is more excellent, and caries in primary teeth number of the infected
It is greatly reduced.
Using above-mentioned desirable embodiment according to the invention as enlightenment, by above-mentioned description, relevant staff is complete
Various changes and amendments can be carried out without departing from the scope of the technological thought of the present invention' entirely.The technology of this invention
Property scope is not limited to the content on specification, it is necessary to determine its technical scope according to right.
Claims (9)
1. a kind of antibacterial mouthwash of bioprotein, which is characterized in that by weight percentage, mainly consist of the following compositions：Ovum
Yellow bioprotein 0.03-1%, isopropyl myristate 0.01-0.5%, Aloesin 0.08-0.1%, surfactant
0.02-0.1%, foaming agent 0.02-0.3%, sweetener 0.2-0.5%, surplus are deionized water；The yolk bioprotein is
To resistance to deformation hammer mattress, streptococcus sobrinus, influenza virus, mycoplasma pneumoniae, five kinds of germs of pneumobacillus compound antibody.
A kind of 2. antibacterial mouthwash of bioprotein as described in claim 1, which is characterized in that the system of the yolk bioprotein
Preparation Method is：
S1：Deformation hammer mattress, streptococcus sobrinus, influenza virus, mycoplasma pneumoniae, pneumobacillus are turned out in selection；
S2：It is mixed with the pathogenic species of S1 cultures by proper proportion；Then 1 is pressed:1 ratio adds in the freund adjuvant of equivalent；It uses again
High speed homogenizer is homogenized at a high speed with 10000-30000rpm and is prepared into complex antigen；
S3：Ostrich of laying eggs is injected with the complex antigen, searches the immune egg that ostrich is given birth to, extraction is made described
Yolk bioprotein.
3. a kind of antibacterial mouthwash of bioprotein as claimed in claim 2, which is characterized in that institute is made in the S3 extractions
The concrete operation method for stating yolk bioprotein is：The yolk of immune egg is taken out with yolk sieve, is beaten uniform；By 1:The body of 6-7
Product is than adding in sterile purified water dilution mixing；PH value is adjusted to 5.2；Concentration is added in as 3% sodium alginate to final concentration of 2.2 ‰,
Stirring is until there is turbidity and precipitation；Add in the CaCl that concentration is 1.5%2Liquid is stirred evenly to final concentration of 1.2 ‰；It is placed in 3-5
When standing 15-20 is small under the conditions of DEG C, supernatant is collected in then siphon, obtains the yolk bioprotein.
4. a kind of antibacterial mouthwash of bioprotein as described in claim 1, which is characterized in that the sweetener is selected from：Stevia rebaudianum
Glucosides, Rubusoside, aspartame, acesulfame or stevioside.
5. a kind of antibacterial mouthwash of bioprotein as described in claim 1, which is characterized in that the surfactant is selected from：
Any one in monoglyceride class, acetylated monoglycerides, sorbitan ester, stearin-based lactate.
6. a kind of antibacterial mouthwash of bioprotein as described in claim 1, which is characterized in that the sweetener is selected from：Stevia rebaudiana
Glycosides, Rubusoside, steviol glycoside or acesulfame.
7. a kind of preparation method of the antibacterial mouthwash of bioprotein as described in claim 1-5 any one, it is characterised in that：
By the proportioning by ostrich Yolk antibody, isopropyl myristate, Aloesin, surfactant, foaming agent, sweetener, go
Ionized water mixes, and is placed in homogenizer and carries out homogenization, and temperature is 5-40 DEG C, time 3-10min.
8. a kind of preparation method of the antibacterial mouthwash of bioprotein as described in claim 1-5 any one, it is characterised in that：
By the proportioning by ostrich Yolk antibody, isopropyl myristate, Aloesin, surfactant, foaming agent, sweetener, go
Ionized water mixes, and is placed in homogenizer and carries out homogenization, time 3-10min.
9. a kind of detection method of the content of microorganisms of the antibacterial mouthwash of bioprotein as described in claim 1, feature exist
In comprising the following steps：
1) the antibacterial mouthwash 5ml of the bioprotein is taken, as sample to be tested, according to 1:10 multiple proportions is diluted, and obtains sample
Product dilution；
2) above-mentioned sample diluting liquid is fitted into triangular flask or test tube, is placed in water bath with thermostatic control and carries out 10~20 points of constant temperature processing
Clock, temperature are 25-35 DEG C；Meanwhile progress constant temperature processing in same water bath is placed in as reference standard liquid using distilled water
10~20 minutes；
3) take out through constant temperature handle sample diluting liquid, conventionally draw and carry out Tu wares, be then placed in incubator into
Row culture；
4) visible bacterium colony is grown within 2~3 days on rear plate, takes out and carries out conventional bacterium colony counting and calculate, obtain in the sample
Total plate count, you can represent the effective microbe content of the antibacterial mouthwash of the bioprotein.
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| CN111135141A (en) * | 2020-01-20 | 2020-05-12 | 蓝佳堂生物医药（福建）有限公司 | Preparation method of composite hydrogel for nasal cavity |
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Effective date of registration: 20180910 Address after: 710065 room 2, No. 11, Tang Yan Nan Road, Xi'an high tech Zone, Shaanxi, China 21004 Applicant after: Xi'an Yu Zi Biotechnology Co., Ltd. Address before: 712000 Diaotai Street Development Zone, Fengxi New Town, Xi'an, Shaanxi Province (Xianxiang Medical and Health Products Factory, Xianyang) Applicant before: SHAANXI RUIKAI BIOTECHNOLOGY CO., LTD. |
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