CN100509039C - Method of preparing Chinese medicine for treating idiopathic thromboeytopenic purpura idiopathic thromboeytopenic purpura - Google Patents

Abstract

The invention relates to a preparation method of a Chinese herbal medicine for treating idiopathic thrombocytopenic purpura, belonging to the technical field of the Chinese herbal medicine preparation method. At present, glucocorticoid such as prednisone is adopted to treat idiopathic thrombocytopenic purpura and is easy to bring side effect. The technical proposal is that: steep rhinoceros horn, root of rehmannia, root of herbaceous peony, herba cirsii, thistle, Chinese arborvitae twig, root of madder, palm, rhizoma imperatae, Chinese rhubarb, gardenia, gromwell, red peony root, pulsatilla chinensis, flos imperatae, loofah, spiranthes sinensis, herba ecliptae, cockscomb, Japanese dock root and tree peony bark in water and boil with slow fire to make into the Chinese herbal medicine for treating idiopathic thrombocytopenic purpura. The Chinese herbal medicine for treating idiopathic thrombocytopenic purpura has the advantages of having a stable curative effect after oral intake and avoiding anaphylactic reaction and gastrointestinal reaction caused by adopting western medicine as well as a plurality of restriction set by using glucocorticoid.

Description

A kind of Chinese medicinal preparation method for the treatment of idiopathic thromboeytopenic purpura idiopathic thromboeytopenic purpura

Technical field

The present invention relates to the Chinese medicinal preparation method technical field, is a kind of Chinese medicinal preparation method for the treatment of idiopathic thromboeytopenic purpura idiopathic thromboeytopenic purpura more specifically.

Background technology

1. the treatment idiopathic thrombocytopenic purpura adopts each 10～20 milligrams of glucocorticoid such as prednisone, every day three times at present.This medicine easily produces drug resistance, and postoperative wound is not healed or the concurrent infection person should not use; To diabetes, hypertension, Peptic Ulcers active stage and renal insufficiency person forbidding.Prolonged application can cause fungal infection.2. use antibacterials such as penicillin, anaphylaxis can occur, as untimely rescue, but threat to life.3. blood transfusion and during platelet transfusion if isoantibody formation easily takes place for infusion repeatedly, causes the rapider destruction of platelet.4. splenectomy postoperative, addisonian crisis appears in the patient who has; The postoperative platelet increases 800,000/cubic millimeter, is prone to thrombosis.5. use immunosuppressant: as cyclophosphamide, can cause leukocyte and platelet and descend, gastrointestinal reaction is as nauseating, vomiting, loss of appetite etc.Vincristin: more outstanding to nervous system toxicity, stomachache, constipation, numb limbs and tense tendons and paraesthesia, Achilles tendon reflex disappearance, cranial nerve palsy, paralytic ileus, blepharoptosis and vocal cord paralysis can appear.Can cause alopecia, heating, feel sick, vomiting and bone marrow depression, can cause long-term misery if permanent nervous system damage occurs.

Summary of the invention

For overcoming above-mentioned shortcoming, the objective of the invention is to invent a kind of Chinese medicinal preparation method for the treatment of idiopathic thromboeytopenic purpura idiopathic thromboeytopenic purpura.Idiopathic thrombocytopenic purpura belongs to blood-heat type person: onset is hurried, have more fear of cold, heating, platelet significantly reduce, mucocutaneous often hemorrhage serious, livid purple speckle or speckle appear in skin, or with epistaxis, bleeding from the gum, have blood in stool, hematuria or heating, thirsty, constipation, red tongue, yellow fur, wiry and frequent pulse are arranged.Lab testing: platelet count reduces (acute stage often is lower than 20,000/cubic millimeter) and paramophia is arranged, increases as volume of platelets, and morphological variation, granule reduces, hyperchromasia.Bleeding time prolongs, and the capillary permeability test is positive, and clot retraction is bad, and thrombinogen consumes bad.Megalokaryocyte quantity is normal or increase in the bone marrow, the megalokaryocyte that platelet forms reduce or lack as.Measure with radioisotope labeling platelet method: platelet life span obviously shortens; Hematoblastic turnover rate is obviously quickened.Its technical scheme is: get Cornu rhinocerotis 9 weight portions, the Radix Rehmanniae 12 weight portions, the Radix Paeoniae Alba 15 weight portions, Herba Cirsii 12 weight portions, Radix Cirsii Japonici 12 weight portions, Cacumen Platycladi 12 weight portions, Radix Rubiae 12 weight portions, Petiolus Trachycarpi 9 weight portions, Rhizoma Imperatae 18 weight portions, Radix Et Rhizoma Rhei 9 weight portions, Fructus Gardeniae 6 weight portions, Radix Arnebiae (Radix Lithospermi) 12 weight portions, Radix Paeoniae Rubra 9 weight portions, the Radix Pulsatillae 12 weight portions, Flos Imperatae 9 weight portions, Retinervus Luffae Fructus 12 weight portions, Radix seu Herba Spiranthis Lanceae 6 weight portions, Herba Ecliptae 12 weight portions, Flos Celosiae Cristatae 9 weight portions, Radix Rumicis Crispi 9 weight portions and Cortex Moutan 12 weight portions, above-mentioned medicine is put into 1200ml water, soaked 50 minutes, slow fire is fried then, fried medicinal liquid double gauze filter and remove residue, fried medicinal liquid are 300 milliliters of Chinese medicines of making the treatment idiopathic thromboeytopenic purpura idiopathic thromboeytopenic purpura.

The advantage of this invention is: processing technology is simple, and this herbal toxic effect is little, oral after, stable curative effect, and in the digestive tract good absorbing.Anaphylaxis, the gastrointestinal reaction that Western medicine produced and many restrictions of using the glucocorticoid defined have been avoided adopting; During platelet transfusion, the platelet destruction that may cause.The addisonian crisis that may occur behind the splenectomy or thrombosis etc. have been avoided.Avoided using the nervous system damage that immunosuppressant caused.Behind oral this Chinese medicine, idiopathic thromboeytopenic purpura idiopathic thromboeytopenic purpura is cured.Cornu rhinocerotis: picric acid, salty-cold, join the army into blood, main clear away heart-fire, warp of liver, stomach be burning hot, outstanding energy clearing away heart-fire for tranquillization, removing summer-heat noxious heat in the blood system.So all calentura, no matter heresy is gone into the heart-nutriment, unconsciousness due to high fever, delirium mania and irritation, or the evil blood system of violating are sent out the speckle dermexanthesis, are told disease such as nosebleed hematochezia, are all key medicine.Experimentation confirms: Cornu rhinocerotis contains calcium carbonate, calcium phosphate etc.Its hydrolyzate contains tyrosine cystine and 2-mercaptopropionic acid etc.The Cornu rhinocerotis decoct can reduce house and exempt from the leukocyte count of peripheral blood, and according to clinical report: Cornu rhinocerotis can be used for lung, stomach, metrorrhagia and treatment thrombocytopenic purpura disease.Because Cornu rhinocerotis plays a major role, so be monarch drug in the process of treatment idiopathic thromboeytopenic purpura idiopathic thromboeytopenic purpura.The Radix Rehmanniae, the Radix Paeoniae Alba, Herba Cirsii, Radix Cirsii Japonici, Cacumen Platycladi, Radix Rubiae, Petiolus Trachycarpi, Rhizoma Imperatae, Radix Et Rhizoma Rhei, Fructus Gardeniae, Radix Arnebiae (Radix Lithospermi), Radix Paeoniae Rubra, the Radix Pulsatillae, Flos Imperatae, Retinervus Luffae Fructus, Radix seu Herba Spiranthis Lanceae, Herba Ecliptae, Flos Celosiae Cristatae, Radix Rumicis Crispi, more than this 19 flavor medicine play heat clearing away YIN nourishing, cooling blood for hemostasis, the yin fluid astringing of enriching blood, subduing inflammation, bowel relieving relieving constipation, eliminating fire and detoxication, parasite killing poison jointly, remove the swollen merit of itching, treat the skin ulcer tinea.In treatment idiopathic thrombocytopenic purpura process, help out, so be ministerial drug.Cortex Moutan, hardship, suffering, be slightly cold.Go into the heart, liver, kidney channel.Clearing away heat and cooling blood, removing heat from the liver to lower the high blood pressure, activating blood circulation and dissipating blood stasis.Can rush down the blood fire second of the three ten-day periods of the hot season.Can strengthen the dissipating rashes effect with above medicine is collaborative, be adjuvant altogether.Forefathers think: the disease of treatment heat in blood blood oozing from the body openings or subcuta neous tissue, unclear its heat then blood is not peaceful, do not grow its moon then fire do not stop, its stasis of blood of not dispelling then fresh blood is not given birth to.This aspect face all turns round and look at, and plays heat-clearing and toxic substances removing altogether, cooling blood for hemostasis, removing blood stasis, parasite killing poison, treats the skin ulcer tinea, removes swollen merit of itching, and really is the good agent of treatment idiopathic thrombocytopenic purpura.Cornu rhinocerotis: bitter, sour, salty, cold.Go into the heart, liver, stomach warp.Clearing away heart-fire for tranquillization, cooling blood for hemostasis, detoxifcation dissipating rashes.The Radix Rehmanniae: sweet, bitter, cold.Go into the heart, liver, kidney channel.The heat clearing away YIN nourishing, cooling blood for hemostasis, promoting the production of body fluid to quench thirst.The Radix Paeoniae Alba: bitter, sour, be slightly cold.Go into liver, spleen channel.The yin fluid astringing of enriching blood, easing the affected liver to relieve pain, yin nourishing suppressing the hyperactive liver.Herba Cirsii: sweet, cool.Go into the heart, small intestinal, urinary bladder channel.Cooling blood for hemostasis, removing blood stasis.Radix Cirsii Japonici: sweet, cool.Go into the heart, small intestinal, urinary bladder channel.Cooling blood for hemostasis, removing blood stasis, subduing inflammation.Cacumen Platycladi: bitter, puckery, be slightly cold.Go into lung, liver, large intestine channel.Cooling blood for hemostasis, growing and blacking hair.Radix Rubiae: bitter, little acid, cold.Go into Liver Channel.Hemostasia and dissipation blood stasis, the removing heat from blood promoting the circulation of blood.Petiolus Trachycarpi: bitter, puckery, flat.Go into lung, liver, large intestine channel.Hemostasis with astringents.Rhizoma Imperatae: sweet, cold.Go into the heart, lung, stomach, urinary bladder channel.Clearing away heat and cooling blood, clearing away heat and promoting production of body fluid, inducing diuresis to remove edema.Radix Et Rhizoma Rhei: bitter, cold.Go into stomach, large intestine, spleen, liver, pericardium channel.The bowel relieving relieving constipation, eliminating fire and detoxication, eliminating blood stasis and inducing menstruation.Fructus Gardeniae: bitter, cold.Go into the heart, liver, lung, stomach, tri-jiao channel.The pathogenic fire purging relieving restlessness, the dampness removing that expels the heat-evil, cooling blood for hemostasis.Radix Arnebiae (Radix Lithospermi): sweet, cold.Go into the heart, Liver Channel.Removing pathogenic heat from blood and toxic substance from the body, rash doctor skin ulcer, diuresis laxation.Radix Paeoniae Rubra: hardship is slightly cold.Go into Liver Channel.Cooling blood for hemostasis, stasis-dispelling and pain-killing, liver heat removing and eyesight improving.The Radix Pulsatillae: hardship, cold.Go into stomach, large intestine channel.Heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.Flos Imperatae: sweet, cold.Go into the heart, lung, stomach, urinary bladder channel.Cooling blood for hemostasis.Retinervus Luffae Fructus: sweet, flat.Go into lung, stomach, Liver Channel.Removing pathogenic heat from blood and toxic substance from the body, the promoting the circulation of blood collateral dredging.Radix seu Herba Spiranthis Lanceae: sweet, little hardship, flat.Go into lung, liver, kidney channel.Removing pathogenic heat from blood and toxic substance from the body, the YIN nourishing tonify deficiency.Herba Ecliptae: sweet, sour, cold.Go into liver, kidney channel.The kidney invigorating tonifying YIN, cooling blood for hemostasis.Flos Celosiae Cristatae: sweet, cold.Go into liver, kidney, large intestine channel.The heat clearing away convergence, hemostasis leukorrhagia stopping, dysentery relieving.Radix Rumicis Crispi: bitter, puckery, cold.Go into the heart, liver, large intestine channel.Cooling blood for hemostasis, the parasite killing poison is treated the skin ulcer tinea, clearing away damp-heat, removes swollen itching.Cortex Moutan: bitter, hot, be slightly cold.Go into the heart, liver, kidney channel.Clearing away heat and cooling blood, removing heat from the liver to lower the high blood pressure, activating blood circulation and dissipating blood stasis.

The specific embodiment

Get Cornu rhinocerotis 9g, Radix Rehmanniae 12g, Radix Paeoniae Alba 15g, Herba Cirsii 12g, Radix Cirsii Japonici 12g, Cacumen Platycladi 12g, Radix Rubiae 12g, Petiolus Trachycarpi 9g, Rhizoma Imperatae 18g, Radix Et Rhizoma Rhei 9g, Fructus Gardeniae 6g, Radix Arnebiae (Radix Lithospermi) 12g, Radix Paeoniae Rubra 9g, Radix Pulsatillae 12g, Flos Imperatae 9g, Retinervus Luffae Fructus 12g, Radix seu Herba Spiranthis Lanceae 6g, Herba Ecliptae 12g, Flos Celosiae Cristatae 9g, Radix Rumicis Crispi 9g and Cortex Moutan 12g, above-mentioned medicine is put into 1200ml water, soaked 50 minutes, slow fire is fried then, fried medicinal liquid double gauze filter and remove residue, fried medicinal liquid are 300 milliliters of Chinese medicines of making the treatment idiopathic thromboeytopenic purpura idiopathic thromboeytopenic purpura.When needs are treated, oral, each 50 milliliters, three times on the one.Seven is a course of treatment, if still have symptom, second course of treatment of reuse is until recovery from illness.

In 261 routine idiopathic thromboeytopenic purpura idiopathic thromboeytopenic purpura people, cure 227 examples, account for 86.97%; 34 examples that take a turn for the better account for 13.03%.Do not find invalid case.

Table one: 261 routine idiopathic thromboeytopenic purpura idiopathic thromboeytopenic purpura human therapy sky numerical tables

The treatment natural law	12～20	21～28	29～35
				The example number	17	193	51
Percentage ratio	6.51％	73.95％	19.54％

Table two: 261 routine idiopathic thromboeytopenic purpura idiopathic thromboeytopenic purpura human therapy cross-reference tables

Claims (1)

1, a kind of Chinese medicinal preparation method for the treatment of idiopathic thromboeytopenic purpura idiopathic thromboeytopenic purpura, it is characterized in that: get Cornu rhinocerotis 9g, Radix Rehmanniae 12g, Radix Paeoniae Alba 15g, Herba Cirsii 12g, Radix Cirsii Japonici 12g, Cacumen Platycladi 12g, Radix Rubiae 12g, Petiolus Trachycarpi 9g, Rhizoma Imperatae 18g, Radix Et Rhizoma Rhei 9g, Fructus Gardeniae 6g, Radix Arnebiae (Radix Lithospermi) 12g, Radix Paeoniae Rubra 9g, Radix Pulsatillae 12g, Flos Imperatae 9g, Retinervus Luffae Fructus 12g, Radix seu Herba Spiranthis Lanceae 6g, Herba Ecliptae 12g, Flos Celosiae Cristatae 9g, Radix Rumicis Crispi 9g and Cortex Moutan 12g, above-mentioned medicine is put into 1200ml water, soaked 50 minutes, slow fire is fried then, fried medicinal liquid double gauze filter and remove residue, fried medicinal liquid are 300 milliliters of Chinese medicines of making the treatment idiopathic thromboeytopenic purpura idiopathic thromboeytopenic purpura.