CN100509032C - Chinese medicinal preparation for treating nasosinusitis and preparation method thereof - Google Patents
Chinese medicinal preparation for treating nasosinusitis and preparation method thereof Download PDFInfo
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- CN100509032C CN100509032C CNB2005100227001A CN200510022700A CN100509032C CN 100509032 C CN100509032 C CN 100509032C CN B2005100227001 A CNB2005100227001 A CN B2005100227001A CN 200510022700 A CN200510022700 A CN 200510022700A CN 100509032 C CN100509032 C CN 100509032C
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Abstract
A Chinese medicine in the form of honeyed pills for treating nasosinusitis, especially the chronic one, is prepared from 10 Chinese-medicinal materials including honeysuckle flower, chrysanthemum flower, bouttuynia, tendrilled fritillary bulb, etc through proportioning, respective grinding, mixing, sieving, honeying and pilling.
Description
Technical field:
The present invention relates to a kind of pharmaceutical composition for the treatment of sinusitis, particularly is the middle medicament and preparation method thereof of the treatment sinusitis of material composition with the Chinese herbal medicine.
Background technology:
" nasal sinuses " is the general designation of nasal cavity gassiness bone cavity maxillary sinus, sinus frontalis, sieve hole, sphenoid sinus.The nasal sinuses inflammation has various clinical manifestations, as: have a stuffy nose but watery nasal discharge, nasal cavity swelling, nasal cavity are scorching, headache, feel sick, symptom such as hypomnesis, be commonly encountered diseases among the crowd, frequently-occurring disease.At present, doctor trained in Western medicine this disease is mainly taked antibiotics injection or puncture, laser, the freezing operative treatment mode that waits.Wherein, instillation antibiotics is long the course of treatment, and operative treatment is relatively more painful again.And the traditional Chinese medical science thinks that this disease is an affection of exogenous wind-cold, due to the endogenous cause of ill visceral dysfunction, so proposed method with the Chinese Traditional Medicines treatment, if any with compatibility sides of being such as the Radix Astragali, cowherb BUSHICAO, Semen Persicae, Flos Magnoliae, Fructus Xanthii, stone Chang algaes, have with compatibility sides of being such as latus rectum grass, Fructus Mume, Flos Chrysanthemis, or the like various Chinese medicine compositions.These medicines are also each has something to recommend him to acute and chronic sinusitis therapeutic effect, and patient's comment differs.
Summary of the invention:
The object of the present invention is to provide a kind of treatment sinusitis, particularly to the specific Chinese formulated products of chronic sinusitis.
Another object of the present invention provides the preparation method of the Chinese formulated products of above-mentioned treatment sinusitis.
Technical solution of the present invention
Sinusitis, according to the detection of doctor trained in Western medicine, it is because multiple harmful pathogenic bacteria, as: due to golden Portugal bacterium, bacillus pyocyaneus, Hemolytic streptococcus, escherichia coli etc. grow, infect at nasal cavity.Chinese medicine thinks that its pathogeny is many because of the dirty yang imbalance of internal organs, due to asthenic fire heat is wet, exopathogenic factor wind and cold is induced in addition.Thereby the present invention is careful to select disease-resistant sterilization, the medicine of human body yin-yang balancing of being in harmonious proportion carries out reasonable compatibility and makes Chinese formulated products, and clinical through being applied to, effect is very apparent.
The primary raw material of the pharmaceutical composition of the careful choosing of the present invention is: Flos Lonicerae, Flos Chrysanthemi, Herba Houttuyniae, Bulbus Fritillariae Uninbracteatae, Radix Bupleuri, Radix Scrophulariae, Semen Pittospori Glabrati, the Radix Rehmanniae, Radix Rubiae, Radix agastaches.
Medicine of the present invention is a compositions of pressing row weight portion proportioning: Flos Lonicerae 30-50, Flos Chrysanthemi 20-40, Herba Houttuyniae 30-40, Bulbus Fritillariae Uninbracteatae 10-20, Radix Bupleuri 10-15, Radix Scrophulariae 20-35, Semen Pittospori Glabrati 10-20, the Radix Rehmanniae 20-45, Radix Rubiae 10-25, Radix agastaches 40-55.
The preferable range that medicine of the present invention makes up by weight is:
Flos Lonicerae 34-45, Flos Chrysanthemi 25-35, Herba Houttuyniae 32-38, Bulbus Fritillariae Uninbracteatae 12-18, Radix Bupleuri 12-14, Radix Scrophulariae 25-30, Semen Pittospori Glabrati 12-18, the Radix Rehmanniae 25-40, Radix Rubiae 15-20, Radix agastaches 45-50.
Above Chinese crude drug is made medicaments preparation method of the present invention: choose state qualified medical material weigh assort, grind respectively roll thin, mix in due order in batches, sieve powder, or again honey refine pill, the steps include:
(1) requires weighing and burden by weight ratio;
(2) roll respectively each medical material of fine lapping, sieve: earlier Bulbus Fritillariae Uninbracteatae is pulverized to grind and is fine powder, cross 100-120 sieves, again Flos Lonicerae, Flos Chrysanthemi, Herba Houttuyniae, Radix Bupleuri, Radix agastaches are rolled into fine powder, cross 80-100 mesh sieves, after the Radix Rehmanniae, Radix Scrophulariae, Semen Pittospori Glabrati, Radix Rubiae are rolled into fine powder, cross 80-100 mesh sieves;
(3) evenly mix successively, sieve: with above-mentioned Bulbus Fritillariae Uninbracteatae powder component, place in the mortar, multiple batches of ground is formed medicine with above-mentioned other such as Flos Lonicerae, Flos Chrysanthemi, Herba Houttuyniae, Radix Bupleuri, Radix Scrophulariae, Semen Pittospori Glabrati, the Radix Rehmanniae, Radix Rubiae, Radix agastaches respectively and is cooperated porphyrize, again the medicamental pulverata after every batch of grinding is all mixed, mixed thoroughly 100-120 mesh sieves;
More than obtained the powder agent medicine that the present invention treats sinusitis.
(4) honey refining is prepared into ball: get above-mentioned powder medicamental pulverata and with the ratio of its weight be that the refined honey of 1:1 rubs up mutually and evenly makes moist agglomerate, is compression molded into ball and gets final product.
Beneficial effect of the present invention:
(1) in the composition medicine of the present invention, Flos Lonicerae has heat-clearing and toxic substances removing and stronger antibacterial action, especially golden Portugal bacterium, bacillus pyocyaneus, Hemolytic streptococcus, escherichia coli etc. is had tangible antibacterial effect; Flos Chrysanthemi has antibiotic, analgesic and hypotensive effect, that Radix Bupleuri also has is analgesic, the effect of function of gallbladder promoting, dispersing the stagnated live-QI to relieve the stagnation of QI; Herba Houttuyniae has heat-clearing and toxic substances removing, detumescence and apocenosis effect; Semen Pittospori Glabrati has the effect of clearing away heat-damp and promoting diuresis, cooling blood for hemostasis, and Radix Scrophulariae has the effect of eliminating fire and detoxication, YIN nourishing and the production of body fluid promoting; Radix agastaches has the function of fragrant expelling summer-heat and damp, and the Radix Rehmanniae has YIN nourishing removing heat from blood, clearing away heat and promoting production of body fluid effect; Bulbus Fritillariae Uninbracteatae has heat-clearing and toxic substances removing, eliminates the effect of pain, subcutaneous ulcer, furuncle; Radix Rubiae also has the effect of cooling blood for hemostasis, promoting blood circulation to restore menstrual flow.Rationally joining of this composition medicine appointed, to because of depletion fire syndrome going up due to having a cold outward, and endogenous cause of ill zang-fu disharmony and the clinical symptoms such as sinusitis that cause have obvious curative effects.
(2) curative effect of the present invention is better than existing other commercially available Chinese medicine pill.For the correct curative effect of estimating, the applicant accepted chronic sinusitis patient 280 examples for medical treatment in 2000-2003 years, wherein: establish treatment at random and organize 150 examples, matched group 130 examples, carry out observation of curative effect.Through two week treatments, the cure rate of treatment group is 83.33%, total effective rate is 100%; The cure rate of matched group is 33.85%, total effective rate is 76.92%.Two groups of cure rates, total effective rates are compared, and the treatment group obviously is better than matched group.Learn by statistics again and handle check, treatment group and matched group x
2Both have significant difference in=5.1 (P＜0.05).As seen, the present invention is also more remarkable to the chronic sinusitis curative effect.
(3) the present invention treats sinusitis, chronic sinusitis particularly, relatively the course of treatment short and be difficult for recurrence, 150 routine former patients were organized in treatment in 2004 to follow up a case by regular visits to, no case was recurrence for the result, now takes out two parts of Visitor Logs at random, to explain:
(1) patient Qiu, lives fish hook town, Huai at man, 27 years old, suffers from chronic sinusitis 8 years, and is ineffective for a long time through other people multi-treatment, and October calendar year 2001 is with three healings courses of treatment of this medicament.In October, 2005, letter was followed up a case by regular visits to, and claimed not recurrence.
(2) patient Zhang, lives Hua Chong town, Shuyang County at man, 12 years old, and long-term headache, rhinorrhea are diagnosed as chronic sinusitis, and in May, 2002 is with two healings courses of treatment of this medicament.In October, 2005, letter was followed up a case by regular visits to, and claimed not recurrence.
(4) simple, the easy row of preparation method of the present invention, low price.
The specific embodiment:
The preferred dry and comfortable medical material of first class, by weight ratio: Flos Lonicerae 40, Flos Chrysanthemi 30, Herba Houttuyniae 35, Bulbus Fritillariae Uninbracteatae 15, Radix Bupleuri 13, Radix Scrophulariae 28, Semen Pittospori Glabrati 15, the Radix Rehmanniae 30, Radix Rubiae 18, Radix agastaches 48, promptly take by weighing Flos Lonicerae 400 grams, Flos Chrysanthemi 300 restrains, Herba Houttuyniae 350 restrains, Bulbus Fritillariae Uninbracteatae 150 restrains, Radix Bupleuri 130 restrains, Radix Scrophulariae 280 restrains, Semen Pittospori Glabrati 150 restrains, the Radix Rehmanniae 300 restrains, Radix Rubiae 180 restrains, Radix agastaches 480 restrains as raw material, goes to prepare powder and pill again.
Its powder preparation method is as follows:
Step (1) is crossed 120 mesh sieves, standby with the Bulbus Fritillariae Uninbracteatae grinding for fine powder.
(2) Flos Lonicerae, Flos Chrysanthemi, Herba Houttuyniae, Radix Bupleuri, Radix agastaches are rolled into fine powder and cross 80-100 mesh sieves.
(3) Radix Rehmanniae, Radix Scrophulariae, Semen Pittospori Glabrati, Radix Rubiae are bundled into fine powder and cross 80-100 mesh sieves.
(4) the Bulbus Fritillariae Uninbracteatae fine powder is divided into nine parts, every part mixes porphyrize with other each medicine respectively.
(5) with above-mentioned all medicament mixed porphyrizes, cross 100-120 mesh sieves, then make less than 2720 gram powders (part may be the loss of medicated powder dirt).
Its pill preparation method is as follows:
Step (1) takes by weighing refined honey 2720 grams.
(2) the refined honey temperature is transferred to about 110 degree, the medicamental pulverata temperature is heated to about 100 degree.
(3) refined honey stirs evenly with medicamental pulverata and rubs up into moist agglomerate, is compression molded into ball immediately.
During the clinical use of the present invention, oral as one feels fit when needing drink according to conditions of patients.
Claims (5)
1, a kind of middle medicament for the treatment of sinusitis is characterized in that: it is the medicament that the following weight parts proportion raw material is formed: Flos Lonicerae 30-50, Flos Chrysanthemi 20-40, Herba Houttuyniae 30-40, Bulbus Fritillariae Uninbracteatae 10-20, Radix Bupleuri 10-15, Radix Scrophulariae 20-35, Semen Pittospori Glabrati 10-20, the Radix Rehmanniae 20-45, Radix Rubiae 10-25, Radix agastaches 40-55.
2, the middle medicament of treatment sinusitis according to claim 1 is characterized in that: wherein the weight portion proportioning of each raw material is: Flos Lonicerae 34-45, Flos Chrysanthemi 25-35, Herba Houttuyniae 32-38, Bulbus Fritillariae Uninbracteatae 12-18, Radix Bupleuri 12-14, Radix Scrophulariae 25-30, Semen Pittospori Glabrati 12-18, the Radix Rehmanniae 25-40, Radix Rubiae 15-20, Radix agastaches 45-50.
3, the middle medicament of treatment sinusitis according to claim 1 is characterized in that: wherein the weight portion proportioning of each raw material is: Flos Lonicerae 40, Flos Chrysanthemi 30, Herba Houttuyniae 35, Bulbus Fritillariae Uninbracteatae 15, Radix Bupleuri 13, Radix Scrophulariae 28, Semen Pittospori Glabrati 15, the Radix Rehmanniae 30, Radix Rubiae 18, Radix agastaches 48.
4, according to claim 1,2 or 3 described a kind of middle medicaments for the treatment of sinusitis, it is characterized in that: described medicament is powder or pill.
5, a kind of preparation method for the treatment of medicament in the sinusitis, it is characterized in that: will weigh by the qualified medical material that claim 1 or 2 or 3 described raw materials in weight portion are formed and assort, grind respectively and roll carefully, mix in due order in batches, sieve powder, or again honey refine pill, the steps include:
(1) requires weighing and burden by weight ratio;
(2) roll respectively each medical material of fine lapping, sieve: earlier Bulbus Fritillariae Uninbracteatae is pulverized to grind and is fine powder, cross 100-120 sieves, again Flos Lonicerae, Flos Chrysanthemi, Herba Houttuyniae, Radix Bupleuri, Radix agastaches are rolled into fine powder, cross 80-100 mesh sieves, after the Radix Rehmanniae, Radix Scrophulariae, Semen Pittospori Glabrati, Radix Rubiae are rolled into fine powder, cross 80-100 mesh sieves;
(3) evenly mix successively, sieve: with above-mentioned Bulbus Fritillariae Uninbracteatae powder component, place in the mortar, multiple batches of ground is formed medicine with above-mentioned other such as Flos Lonicerae, Flos Chrysanthemi, Herba Houttuyniae, Radix Bupleuri, Radix Scrophulariae, Semen Pittospori Glabrati, the Radix Rehmanniae, Radix Rubiae, Radix agastaches respectively and is cooperated porphyrize, again the medicamental pulverata after every batch of grinding is all mixed, mixed thoroughly 100-120 mesh sieves, become powder agent medicine;
(4) honey refining is prepared into pill: get above-mentioned powder medicamental pulverata and with the ratio of its weight be that the refined honey of 1:1 rubs up mutually and evenly makes moist agglomerate, is compression molded into ball.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100227001A CN100509032C (en) | 2005-12-28 | 2005-12-28 | Chinese medicinal preparation for treating nasosinusitis and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100227001A CN100509032C (en) | 2005-12-28 | 2005-12-28 | Chinese medicinal preparation for treating nasosinusitis and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1824142A CN1824142A (en) | 2006-08-30 |
| CN100509032C true CN100509032C (en) | 2009-07-08 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2005100227001A Expired - Fee Related CN100509032C (en) | 2005-12-28 | 2005-12-28 | Chinese medicinal preparation for treating nasosinusitis and preparation method thereof |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102614306B (en) * | 2012-04-18 | 2013-06-26 | 南阳医学高等专科学校 | Traditional Chinese herbal preparation for treating chronic nasosinusitis |
| CN102614413B (en) * | 2012-04-28 | 2013-08-07 | 曹广雪 | Chinese medicinal composition for treating sinusitis in children and preparation method thereof |
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2005
- 2005-12-28 CN CNB2005100227001A patent/CN100509032C/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 鼻炎合剂治疗儿童鼻窦炎的临床观察. 苏虹，李菁.实用中西医结合杂志，第11卷第3期. 1998 |
| 鼻炎合剂治疗儿童鼻窦炎的临床观察. 苏虹，李菁.实用中西医结合杂志，第11卷第3期. 1998 * |
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| CN1824142A (en) | 2006-08-30 |
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Granted publication date: 20090708 Termination date: 20111228 |