CN100506218C - Spider aroma preparation for treating diarrhea and preparation method thereof - Google Patents
Spider aroma preparation for treating diarrhea and preparation method thereof Download PDFInfo
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- CN100506218C CN100506218C CNB2004100795452A CN200410079545A CN100506218C CN 100506218 C CN100506218 C CN 100506218C CN B2004100795452 A CNB2004100795452 A CN B2004100795452A CN 200410079545 A CN200410079545 A CN 200410079545A CN 100506218 C CN100506218 C CN 100506218C
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Abstract
The invention provides a spider aroma preparation for treating diarrhea and preparation method, wherein the preparation comprises spider aroma 0.1-99.9%, and balancing medicinal adjuvant 0.1-99.9%. The preparation has very good therapeutic effect for treating diarrhea caused by rotavirus.
Description
Technical field
The present invention relates to the oral formulations of Rhizoma valerianae latifoliae, particularly relate to Rhizoma valerianae latifoliae granule, coated granule, hard capsule, soft capsule, drop pill, enteric coated capsule, tablet, enteric coatel tablets.
Background technology
Diarrhoeal diseases always is to threaten the particularly serious infectious diseases of infantile health of human health, and wherein the diarrhoea that is caused by rotavirus is global and is widely current and does not have the specific treatment medicine.No matter developed country or developing country, the infant more than 90% all will be subjected to rotavirus infection before 3 years old.In 5 years old infant of being in hospital with lower abdominal diarrhea, the rotavirus infection case accounts for 20%～70%.Chinese children rotavirus diarrhea year admission rate is up to 13 ‰, and seasonal popular peak is all arranged every year.The B group rotavirus that is called as adult diarrhea rotavirus is the novel rotavirus that isolated in China is identified, and is only popular in China mainland.Attention is to the monitoring and the study on prevention of rotavirus diarrhea, and is very necessary.
(Human Rotavirus is an infant diarrheal autumn and winter main pathogen HRV) to Human reoviruslike agent, and according to WHO, annual nearly approximately 1,000,000 infant are died from HRV, and 11%～71% (average 33%) is caused by HRV in the diarrhoea infant.In developed country, the infant acute gastroenteritis of being in hospital is about to be due to the HRV more than 1/3～1/2.Account for 50%～80% of infantile rotavirus enteritis in China.In the diarrhoea below 5 years old was in hospital infant, HRV enteritis accounted for 20%～70%.
HRV belongs to a kind of RNA viruses of Reoviridae, and the specific antigen of complying with its internal layer capsid polypeptide is divided into A, B, C, D, E, F, G group, but has only A, B, three groups of energy of C infected person, and wherein modal is the A group.The antigenicity of B group HRV is different fully with the A group, mainly causes adult diarrhea, once causes that China millions of people diarrhoea was very popular the eighties in 20th century, and is rare in recent years.
Digestive tract is the main route of transmission of HRV, and often there are water type and food type outbreak of epidemic in nurseries and kindergartens unit or school.1994, twice of China in 1997 novel HRV diarrhoea outbreak of epidemic is by due to the water supply pollution.Contact transmission also extensively exists, and the Close contacts of family can have the secondary infection more than 30%.
Patient and asymptomatic carrier are the source of infection of HRV.Symptom preceding 1 day feces occurs and begins row's virus, and the 3rd, 4 sick days is the toxin expelling peak, and output can reach 10
13～10
15/ L, susceptible only need 10 months virus to infect.All toxin expellings stop mostly after being ill, but 2 weeks of minority toxin expelling, and only a few can form chronic diarrhea and long-term toxin expelling.The band poison rate of ill mother's baby feces can reach about 70%.
A group HRV mainly infects infant, and secondly the highest 6～12 monthly ages of age of onset are 12～24 monthly ages and 2～6 monthly ages.But neonate, also can infect when being grown up particularly old people's hypoimmunity.The artificial feeding person is than breast feeding susceptible disease more.Infant more than 90% all once was subjected to the infection of HRV before 3 years old.B group HRV mainly infects person between twenty and fifty, and this antibody positive rate only 4% in the population of China, and positive rate about 30% among the between twenty and fifty crowd.The main infected children of C group HRV.Population of China is generally lower to infectibility height, the withstand force of novel HRV.
HRV mainly invades duodenum and jejunum, and viral the combination with host cell receptor is the key of viral infection.In recent years discover, there is the HRV receptor on the enterocyte film, HRV coat protein VP4 is the adhesion protein of virus infected cell, enter epithelial cell by combining, in the epithelial cell endochylema, duplicate then, make the fine hair chap that shortens with receptor in target cell, cytomorphosis, it is downright bad then cavity to occur, makes the Small Intestine forfeiture, causes diarrhoea.Simultaneously, the hyposecretion of the disaccharidase of secondary does not stagnate in enteric cavity disaccharidase class in the food (lactose, sucrose etc.) digestion entirely, and by bacterial decomposition generation organic acid, the interior osmotic pressure of enteric cavity is increased, moisture oozes out, the decomposition of disaccharidase does not also cause the dysfunction of microvillus epithelial cell sodium transport entirely, further causes power and water to separate the forfeiture of matter, causes dehydration, acidosis and electrolyte disturbance.HRV can cause viremia by gastrointestinal tract barrier after infecting human body, can detect HRV in liver, kidney, feces, cerebrospinal fluid, peripheral blood lymphocytes etc.HRV can with the corresponding receptors bind of mononuclear cell, erythrocyte membrane, platelet membrane, liver, nephrocyte film, cause these primary cellular defects, thereby the gastrointestinal tract that causes HRV to infect shows outward.Discovered in recent years HRV can cause that multiple intestinals such as rhinitis, pharyngolaryngitis, tonsillitis, encephalitis, hepatitis, myocarditis show outward, child at immunocompromised host, HRV can cause the whole body severe infections and cause death that the incidence rate that HRV infects dependency hepatitis is 8.78%.
At present, doctor trained in Western medicine still lacks the specific treatment method to HRV diarrhoea, mainly is by dietetic therapy and fluid therapy, with controlling symptoms, corrects water, electrolyte disturbance.Motherland's medical science thinks, HRV enteritis belongs to the traditional Chinese medical science category of having loose bowels, and insufficiency of the spleen, the wet Sheng is the main cause that causes primary disease, and method of treatment is many to be controlled with dialectical the executing of compound preparation, and oral administration is main, secondly retention enema and applying ointment or plaster.
Rhizoma valerianae latifoliae has another name called Herba Asari, is Valerianaceae plant lobus cardiacus Rhizoma et radix valerianae Valeriana jatamansii Jones rhizome and root, the main place of production in Yunnan, China southwests such as Sichuan, Guizhou, the reserves in Yunnan Province are very abundant.Rhizoma valerianae latifoliae is shown in " the southern regions of the Yunnan Province book on Chinese herbal medicine " all on the books at China medicine ancient books Li Shizhen (1518-1593 A.D.) Compendium of Material Medica and Lan Mao, Compendium of Material Medica is said: " the Herba Asari abnormal smells from the patient is hot warm, nontoxic "." ward off pestilence ".And recorded in China's pharmacopeia (version in 1977) and Yunnan Province's drug standard (version in 1974, version in 1996), have regulating QI to relieve pain, an antidiarrheal efficacy that is good for the stomach, be used for the treatment of infantile malnutrition, abdominal distention, dyspepsia, diarrhoea.Rhizoma valerianae latifoliae is extensive use of among the people, and origin stream is long, is the good medicine of the multiple national successive dynasties treating infantile diarrhea according to legend.
Rhizoma valerianae latifoliae contains volatile oil, is mainly australene, limonene, and 1,8-cineole, borneol acetate etc.; Still contain acevaltratum, valepotriate, dihydro acevaltratum, valerosidatum, linarin etc.Valepotriate content reaches 2.34%, be Rhizoma valerianae latifoliae spasmolytic, main effective ingredient eases pain.Rhizoma valerianae latifoliae has the function of regulating QI to relieve pain, antiinflammatory antidiarrheal, expelling wind and removing dampness, is used for abdominal distention, dyspepsia, diarrhoea, dysentery, rheumatic arthralgia, soreness of the waist and knees.
Nineteen eighty-two is safe and effective with Rhizoma valerianae latifoliae decocting liquid (autumn is rushed down spirit) treatment children's HRV enteritis 74 examples.Zoopery shows, the autumn is rushed down spirit, and HRV is infected the tree shrew average antidiarrheal time is 18 hours, and the blank group is 93 hours, and ORS treatment group is 56 hours, three treated animals average weightless 2.5,6.6 and 6.8g, and the result shows that the autumn rushes down clever curative effect and be better than ORS.The average antidiarrheal time was 7 hours when the V-Poly extract part of Rhizoma valerianae latifoliae was used for tree shrew that HRV infects, be better than V-gly extract part (average antidiarrheal time 26h), and decocting liquid (average antidiarrheal time 10h), therefore, the V-Poly extract part may be the anti-HRV effective ingredient of Rhizoma valerianae latifoliae.
Autumn is rushed down spirit treatment 311 routine children's HRV enteritis, average course of disease 63.3 ± 29.8 hours, antidiarrheal rate, the rate of bringing down a fever were respectively 83.1% and 99.1% on 3, gentamycin matched group (76 example) average course of disease 65.8 ± 30.1 hours, and antidiarrheal on the 3rd and the rate of bringing down a fever are respectively 61.0% and 66.7%.
Rush down spirit with the autumn and treat different RNA type HRV enteritis, in 30 routine RNA elongated (HRV-L) infants, 9 routine produce effects, 19 examples are effective, and 2 examples are invalid; In the short type infant of 18 routine RNA, 3 routine produce effects, 7 examples effectively, 8 examples are invalid, the prompting autumn rushes down clever antitoxin activity to dissimilar HRV and there are differences, can promote to recover body function and the structural damage that HRV-L type HRV causes, and can promote to recover and correct the fat digestion dysfunction that HRV-L type HRV causes.
Rhizoma valerianae latifoliae is treated 390 routine non-HRV enteritis 96 hours antidiarrheal rates, the rates of bringing down a fever and is respectively 94.44% and 91.38%, be better than 77.42% and 72.73% of gentamycin matched group (31 example), show that Herba Asari is not only effective to HRV enteritis, and non-HRV enteritis also had better curative effect, may be with its inhibition enterokinesia, enhancing human body immunity power, to promote intestinal mucosal lesion to repair relevant.
In view of still not having under the situation of specific treatment medicine at present, the world of medicine all takes much count of screening treatment children's rotavirus diarrheal active drug both at home and abroad, especially pay attention to the screening of natural drug, this class medicine of research and development from natural drug, the special superiority with resource and Chinese medical theory aspect.
Rhizoma valerianae latifoliae is the safe and effective natural drug for the treatment of HRV enteritis at present, but its preparation only has decocting oral liquid (autumn is rushed down spirit) a kind of, autumn rushes down spirit and adopts decocting to boil technology in preparation process, cause on the one hand loss of volatile oil, can not leach water insoluble ingredients such as valepotriate on the other hand, and the special bad smell of Rhizoma valerianae latifoliae causes child and old people's nausea and vomiting easily, is unfavorable for patient's medication.
Summary of the invention
The invention reside in the shortcoming that overcomes above-mentioned decocting oral liquid, invent a kind of the employing earlier with ethanol extraction, the technology extracted of decocting again, fully nonpolarity element and water solublity polar components such as the volatile oil of proposition Rhizoma valerianae latifoliae, valepotriate guarantee that its clinical efficacy is able to comprehensive performance; Re-use coating or solid dispersion technology, dosage form is selected solid preparation for use, has greatly dwindled injection volume, and more convenient patient takes, and drug quality is maintained a long-term stability.
The present invention is used for the treatment of diarrheal Rhizoma valerianae latifoliae preparation and preparation method is such: essence contains Rhizoma valerianae latifoliae 0.1-99.9% in the preparation, and its surplus is medicine adjuvant 99.9-0.1%; Described preparation is granule, coated granule, hard capsule, soft capsule, drop pill, enteric coated capsule, tablet, enteric coatel tablets, microcapsule.
Rhizoma valerianae latifoliae dry extract extracting method is as follows: Rhizoma valerianae latifoliae cleans and is ground into coarse powder, adds 5-10 and doubly measures 50-95% alcohol reflux secondary, each 0.5-3 hour, filter, and filtrate decompression concentrates, vacuum drying gets dry extract; Medicinal residues behind the ethanol extraction add 5-10 times of water gaging, and 70-95 ℃ is stirred extraction 0.5-3 hour, filters, and filtrate decompression is concentrated into thick paste, and vacuum drying merges to such an extent that the Rhizoma valerianae latifoliae dry extract is standby with above-mentioned dry extract.Described solvent is water, ethanol; Described adjuvant is Polyethylene Glycol, starch, soluble starch, dextrin, liquid Paraffin, Span-60, magnesium stearate, PEG6000, petroleum ether; Described correctives is Folium Caryophylli oil, Oleum menthae, rose absolute, jasmine flower essence, Mel, sucrose, saccharin sodium; The preparation method of described Rhizoma valerianae latifoliae granule is: the Rhizoma valerianae latifoliae dry extract is pulverized, is sieved, and with starch, dextrin auxiliary materials and mixing, granulate, drying, mixing, packing, promptly; The preparation method of described Rhizoma valerianae latifoliae coated granule agent formulation is: the Rhizoma valerianae latifoliae dry extract is pulverized, is sieved, and with starch, dextrin auxiliary materials and mixing, granulate, the bag film-coat, packing, promptly; The preparation method of described Rhizoma valerianae latifoliae hard capsule preparation is: the Rhizoma valerianae latifoliae dry extract is pulverized, sieved, and mix with appropriate amount of auxiliary materials, mixing is granulated, and is packed in the hard capsule, promptly.The preparation method of described Rhizoma valerianae latifoliae soft capsule preparation is: the Rhizoma valerianae latifoliae dry extract is pulverized, is sieved, and with the Polyethylene Glycol auxiliary materials and mixing, make soft capsule, promptly.The preparation method of described Rhizoma valerianae latifoliae drop pill is as follows: the Rhizoma valerianae latifoliae dry extract is pulverized, is sieved, and with the Polyethylene Glycol auxiliary materials and mixing, make drop pill, promptly; The preparation method of described Rhizoma valerianae latifoliae enteric hard capsule is as follows: the Rhizoma valerianae latifoliae dry extract is pulverized, sieved, mix with appropriate amount of auxiliary materials, mixing is granulated, and is packed in the enteric solubility hard capsule, promptly.The preparation method of described Rhizoma valerianae latifoliae tablet formulation is: the Rhizoma valerianae latifoliae dry extract pulverized, sieved, and mix with appropriate amount of auxiliary materials, and mixing, compacting is in blocks, promptly; The preparation method of described Rhizoma valerianae latifoliae enteric coatel tablets preparation is: the Rhizoma valerianae latifoliae dry extract pulverized, sieved, mix with appropriate amount of auxiliary materials, and mixing, compacting is wrapped enteric film coat, promptly in flakes.The preparation method of described Rhizoma valerianae latifoliae microcapsule preparation is: the Rhizoma valerianae latifoliae dry extract is pulverized, is sieved, and add appropriate amount of auxiliary materials, make microcapsule granule with suitable method, be packed in the hard capsule or compacting in flakes, promptly
The used solvent of the present invention is water, ethanol.
The used adjuvant of the present invention is Polyethylene Glycol, starch, soluble starch, dextrin, liquid Paraffin, Span-60, magnesium stearate, PEG6000, petroleum ether etc.
The used correctives of the present invention is Folium Caryophylli oil, Oleum menthae, rose absolute, jasmine flower essence, Mel, sucrose, saccharin sodium.According to requirements of different users, in preparation, add and come correctives together.
The present invention is according to the effective ingredient physicochemical property of Rhizoma valerianae latifoliae, and this technology is removed impurity such as starch a large amount of in the Rhizoma valerianae latifoliae, colloid, thousand dimensions effectively.Preparation process adopts coating or solid dispersion technology, makes volatile ingredient be difficult for ease and loses, have safety, effectively, advantage such as steady quality, patient's compliance be good.Rhizoma valerianae latifoliae preparation of the present invention has better therapeutic effect to diarrhoea and other the various diarrhoea that rotavirus causes, especially infant mortality rate higher rotavirus diarrhoea and senile rotavirus enteritis is had more satisfactory therapeutic effects.
The specific embodiment
By specific embodiment given below and experimental data material, can further be well understood to preparation of the present invention and application of the present invention.But they are not limitation of the invention.
The preparation of embodiment 1 Rhizoma valerianae latifoliae dry extract
Rhizoma valerianae latifoliae 10kg cleans, be ground into coarse powder (particle diameter＜5mm), add 70 liter of 95% alcohol reflux secondary, each 0.5-3 hour, filter, merging filtrate concentrating under reduced pressure, vacuum drying (＜60 ℃) get dry extract; Medicinal residues after the alcohol extraction add 5-10 times of water gaging, and 70-95 ℃ stir to be extracted 0.5-3 hour, filtered, and filtrate decompression is concentrated into thick paste, vacuum drying (＜60 ℃), with above-mentioned dried cream merge the Rhizoma valerianae latifoliae dry extract.
The embodiment of embodiment 2 Rhizoma valerianae latifoliae granules
1. fill a prescription
Rhizoma valerianae latifoliae dry extract 0.1g (0.1%)
Soluble starch 99.9g (99.9%)
2. method for making
Make granule after each supplementary material weighing, mixing with the prescription consumption, packing, promptly.
The embodiment of embodiment 3 Rhizoma valerianae latifoliae granules
1. fill a prescription
Rhizoma valerianae latifoliae dry extract 99.9g (99.9%)
Soluble starch 0.1g (0.1%)
2. method for making
Make granule after each supplementary material weighing, mixing with the prescription consumption, packing, promptly.
The embodiment of embodiment 4 Rhizoma valerianae latifoliae granules
1. fill a prescription
Rhizoma valerianae latifoliae dry extract 50.0g (50.0%)
Soluble starch 50.0g (50.0%)
2. method for making
Make granule after each supplementary material weighing, mixing with the prescription consumption, packing, promptly.
The embodiment of embodiment 5 Rhizoma valerianae latifoliae coated granules
The granule of embodiment 2,3,4 is carried out behind the film coating promptly.
The embodiment of embodiment 6 Rhizoma valerianae latifoliae hard capsules
Embodiment 2,3,4 particles filled gone in the Capsules promptly.
The embodiment of embodiment 7 Rhizoma valerianae latifoliae enteric coated capsulees
Embodiment 2,3,4 particles filled gone in the enteric solubility Capsules promptly.
The embodiment of embodiment 8 Aranea scented teas
1. fill a prescription
Rhizoma valerianae latifoliae dry extract 0.1g (0.1%)
Dextrin 99.4g (99.4%)
Magnesium stearate 0.5g (0.5%)
2. method for making
With each supplementary material weighing, mixing, granulation, tabletting of prescription consumption, promptly.
The embodiment of embodiment 9 Aranea scented teas
1. fill a prescription
Rhizoma valerianae latifoliae dry extract 99.9g (99.9%)
Magnesium stearate 0.1g (0.1%)
2. method for making
With each supplementary material weighing, mixing, granulation, tabletting of prescription consumption, promptly.
The embodiment of embodiment 10 Aranea scented teas
1. fill a prescription
Rhizoma valerianae latifoliae dry extract 50.0g (50.0%)
Dextrin 49.5g (49.5%)
Magnesium stearate 0.5g (0.5%)
2. method for making
With each supplementary material weighing, mixing, granulation, tabletting of prescription consumption, promptly.
The embodiment of embodiment 11 Rhizoma valerianae latifoliae enteric coatel tablets
With behind the Rhizoma valerianae latifoliae tablet bag enteric solubility film-coat of embodiment 8,9,10 promptly.
The embodiment of embodiment 12 Rhizoma valerianae latifoliae soft capsules
1. fill a prescription
Rhizoma valerianae latifoliae dry extract 0.1g (0.1%)
Polyethylene Glycol 99.9g (99.9%)
2. method for making
With the prescription consumption each supplementary material weighing, mixing, be pressed into soft capsule, promptly.
The embodiment of embodiment 13 Rhizoma valerianae latifoliae soft capsules
1. fill a prescription
Rhizoma valerianae latifoliae dry extract 99.9g (99.9%)
Polyethylene Glycol 0.1g (0.1%)
2. method for making
With the prescription consumption each supplementary material weighing, mixing, be pressed into soft capsule, promptly.
The embodiment of embodiment 14 Rhizoma valerianae latifoliae soft capsules
1. fill a prescription
Rhizoma valerianae latifoliae dry extract 50.0g (50.0%)
Polyethylene Glycol 50.0g (50.0%)
2. method for making
With the prescription consumption each supplementary material weighing, mixing, be pressed into soft capsule, promptly.
The embodiment of embodiment 15 Rhizoma valerianae latifoliae drop pill
1. fill a prescription
Rhizoma valerianae latifoliae dry extract 0.1g (0.1%)
Polyethylene Glycol 99.9g (99.9%)
2. method for making
With the prescription consumption each supplementary material weighing, mixing, make drop pill, promptly.
The embodiment of embodiment 16 Rhizoma valerianae latifoliae drop pill
1. fill a prescription
Rhizoma valerianae latifoliae dry extract 99.9g (99.9%)
Polyethylene Glycol 0.1g (0.1%)
2. method for making
With the prescription consumption each supplementary material weighing, mixing, make drop pill, promptly.
The embodiment of embodiment 17 Rhizoma valerianae latifoliae drop pill
1. fill a prescription
Rhizoma valerianae latifoliae dry extract 50.0g (50.0%)
Polyethylene Glycol 50.0g (50.0%)
2. method for making
With the prescription consumption each supplementary material weighing, mixing, make drop pill, promptly.
The embodiment of embodiment 18 Rhizoma valerianae latifoliae microcapsules
1. fill a prescription
Rhizoma valerianae latifoliae dry extract 50.0g
Liquid Paraffin 250g
Span-60 8g
PEG6000 60g
Petroleum ether 100ml
2. method for making
Liquid Paraffin and Span-60 merge heat fused, add Rhizoma valerianae latifoliae dry extract and PEG6000 when being chilled to 100 ℃, stir, mixing, drip petroleum ether when being chilled to 60 ℃, filter, collect precipitum, the an amount of flush away liquid paraffin of petroleum ether, most petroleum ether is waved in 40-50 ℃ of aeration-drying, gets microcapsule, this microcapsule is packed in the hard capsule or compacting in flakes, promptly.
Claims (7)
1, a kind of diarrheal Rhizoma valerianae latifoliae formulation preparation method that is used for the treatment of, it is characterized in that essence contains Rhizoma valerianae latifoliae dry extract 0.1-50% in the preparation, its surplus is medicine adjuvant 99.9-50%, described preparation is granule, coated granule, hard capsule, soft capsule, drop pill, enteric coated capsule, tablet, enteric coatel tablets, microcapsule, wherein Rhizoma valerianae latifoliae dry extract extracting method is as follows: Rhizoma valerianae latifoliae cleans and is ground into coarse powder, add 5-10 and doubly measure 50-95% alcohol reflux secondary, each 0.5-3 hour, filter, and filtrate decompression concentrates, vacuum drying gets dry extract; Medicinal residues behind the ethanol extraction add 5-10 times of water gaging, and 70-95 ℃ is stirred extraction 0.5-3 hour, filters, and filtrate decompression is concentrated into thick paste, and vacuum drying merges to such an extent that the Rhizoma valerianae latifoliae dry extract is standby with above-mentioned dry extract.
2, the diarrheal Rhizoma valerianae latifoliae formulation preparation method that is used for the treatment of according to claim 1 is characterized in that described solvent is water, ethanol; Described adjuvant is Polyethylene Glycol, starch, soluble starch, dextrin, liquid Paraffin, Span-60, magnesium stearate, PEG6000, petroleum ether; Described correctives is Folium Caryophylli oil, Oleum menthae, rose absolute, jasmine flower essence, Mel, sucrose, saccharin sodium.
3, be the described diarrheal Rhizoma valerianae latifoliae formulation preparation method that is used for the treatment of according to claim 1, it is characterized in that the preparation method of described Rhizoma valerianae latifoliae granule is: the Rhizoma valerianae latifoliae dry extract is pulverized, is sieved, and with starch, dextrin auxiliary materials and mixing, granulate drying, mixing, packing, promptly; The preparation method of described Rhizoma valerianae latifoliae coated granule agent formulation is: the Rhizoma valerianae latifoliae dry extract is pulverized, is sieved, and with starch, dextrin auxiliary materials and mixing, granulate, the bag film-coat, packing, promptly.
4, the diarrheal Rhizoma valerianae latifoliae formulation preparation method that is used for the treatment of according to claim 1 is characterized in that the preparation method of described Rhizoma valerianae latifoliae hard capsule preparation is: the Rhizoma valerianae latifoliae dry extract is pulverized, sieved, and mix with appropriate amount of auxiliary materials, mixing, granulate, be packed in the hard capsule, promptly; The preparation method of described Rhizoma valerianae latifoliae soft capsule preparation is: the Rhizoma valerianae latifoliae dry extract is pulverized, is sieved, and with the Polyethylene Glycol auxiliary materials and mixing, make soft capsule, promptly.
5, the diarrheal Rhizoma valerianae latifoliae formulation preparation method that is used for the treatment of according to claim 1 is characterized in that the preparation method of described Rhizoma valerianae latifoliae drop pill is as follows: the Rhizoma valerianae latifoliae dry extract is pulverized, is sieved, and with the Polyethylene Glycol auxiliary materials and mixing, make drop pill, promptly; The preparation method of described Rhizoma valerianae latifoliae enteric hard capsule is as follows: the Rhizoma valerianae latifoliae dry extract is pulverized, sieved, mix with appropriate amount of auxiliary materials, mixing is granulated, and is packed in the enteric solubility hard capsule, promptly.
6, the diarrheal Rhizoma valerianae latifoliae formulation preparation method that is used for the treatment of according to claim 1 is characterized in that the preparation method of described Rhizoma valerianae latifoliae tablet formulation is: the Rhizoma valerianae latifoliae dry extract pulverized, sieved, and mix with appropriate amount of auxiliary materials, and mixing, compacting is in blocks, promptly; The preparation method of described Rhizoma valerianae latifoliae enteric coatel tablets preparation is: the Rhizoma valerianae latifoliae dry extract pulverized, sieved, mix with appropriate amount of auxiliary materials, and mixing, compacting is wrapped enteric film coat, promptly in flakes.
7, the diarrheal Rhizoma valerianae latifoliae formulation preparation method that is used for the treatment of according to claim 1, the preparation method that it is characterized in that described Rhizoma valerianae latifoliae microcapsule preparation is: the Rhizoma valerianae latifoliae dry extract is pulverized, sieved, and adding appropriate amount of auxiliary materials, make microcapsule granule with suitable method, be packed in the hard capsule or compacting in flakes, promptly.
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| CN100478000C (en) * | 2005-09-13 | 2009-04-15 | 闫智勇 | Application of valeriana wallichii and its extract in preparation of medicine for treating anxiety neurosis |
| CN102240308A (en) * | 2010-05-12 | 2011-11-16 | 中国人民解放军军事医学科学院军事兽医研究所 | Application of valeriana jatamansi jones to preparation of anti-canine parvovirus medicament |
| CN102846681A (en) * | 2012-07-25 | 2013-01-02 | 魏艳海 | Medicament for treating livestock diarrhea |
| CN103169825A (en) * | 2012-11-28 | 2013-06-26 | 沈阳伟嘉牧业技术有限公司 | Drug for treating enteric disease of beasts and birds |
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| CN1634370A (en) | 2005-07-06 |
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